Detailed information for compound 257856

Basic information

Technical information
  • TDR Targets ID: 257856
  • Name: AIDS-228112
  • MW: 517.654 | Formula: C29H43NO7
  • H donors: 2 H acceptors: 5 LogP: 4.31 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=CC12CC3C(C2(C(=O)O)C(=C3)C(C)C)(CC2C1CC[C@H]2C)CCOC(=O)[C@@H](NC(=O)OC(C)(C)C)C
  • InChi: 1S/C29H43NO7/c1-16(2)22-12-19-13-28(15-31)21-9-8-17(3)20(21)14-27(19,29(22,28)24(33)34)10-11-36-23(32)18(4)30-25(35)37-26(5,6)7/h12,15-21H,8-11,13-14H2,1-7H3,(H,30,35)(H,33,34)/t17-,18+,19?,20?,21?,27?,28?,29?/m1/s1
  • InChiKey: XEDKRRCOXKEHLS-MRXOVKSOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AIDS228112
  • 1,4-Methano-s-indacene-3a(1H)-carboxylic acid, 8a-[2-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxopropyl]oxy]ethyl]-4-formyl-4,4a,5,6,7,7a,8,8a-octahydro-7-methyl-3-(1-methylethyl)-, (7R)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus GPCR family 2 0.0017 0.0019 0.0035
Brugia malayi ImpB/MucB/SamB family protein 0.0067 0.0227 0.0704
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0048 0.0148 0.0132
Leishmania major glucose transporter, lmgt3 0.0014 0.0009 0.012
Brugia malayi Thioredoxin reductase 0.0046 0.0139 0.0432
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0107 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.045 0.5707
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0031 0.0056
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0154 0.0584 0.065
Echinococcus granulosus solute carrier family 22 0.0014 0.0009 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0038 0.0069
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0068 0.2017
Chlamydia trachomatis transglycolase/transpeptidase 0.1137 0.4617 0.4608
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0009 0.012
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0237 0.0264
Trichomonas vaginalis set domain proteins, putative 0.0729 0.2945 0.5588
Schistosoma mansoni sugar transporter 0.0014 0.0009 0.0017
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.1035 0.4199 0.7454
Trypanosoma cruzi DNA polymerase kappa, putative 0.0121 0.045 0.5707
Mycobacterium tuberculosis Conserved protein 0.007 0.0237 0.0421
Echinococcus multilocularis lamin 0.0026 0.0059 0.0108
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0084 0.0262
Echinococcus multilocularis solute carrier family 22 0.0014 0.0009 0.0017
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0211 0.2676
Brugia malayi hypothetical protein 0.0021 0.0038 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0359 0.0659
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0107 0.0299
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.0257 0.0456
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0237 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.1296 0.5271 1
Schistosoma mansoni sugar transporter 0.0014 0.0009 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0084 0.016
Toxoplasma gondii facilitative glucose transporter GT1 0.0014 0.0009 0.0135
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0016 0.0205
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0016 0.0016
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0204 0.0788 0.1446
Schistosoma mansoni pyruvate kinase 0.0032 0.0084 0.0155
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0055 0.1623
Brugia malayi chromobox protein homolog 3 0.0038 0.0107 0.0332
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0016 0.0481
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0641 0.2583 0.803
Treponema pallidum penicillin-binding protein (pbp-1) 0.2448 1 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0237 0.0421
Echinococcus multilocularis chromobox protein 1 0.0068 0.0229 0.0421
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0035
Trypanosoma brucei glucose transporter, putative 0.0014 0.0009 0.012
Schistosoma mansoni glucose transport protein 0.0014 0.0009 0.0017
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0037 0.0464
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0035
Mycobacterium ulcerans glutaminase 0.0293 0.1153 0.1284
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0084 0.1069
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0084 0.0262
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0016 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0107 0.0202
Onchocerca volvulus 0.0014 0.0009 0.0032
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0055 0.0692
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0016 0.003
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0257 0.7653
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0055 0.0692
Schistosoma mansoni rotamase 0.0032 0.0084 0.0155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.088 0.3564 0.6761
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0031 0.0098
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0752 0.3036 0.539
Plasmodium falciparum glutathione reductase 0.0046 0.0139 0.5406
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0177 0.0678 0.8609
Onchocerca volvulus 0.0171 0.0652 0.2215
Trypanosoma cruzi DNA polymerase kappa, putative 0.0121 0.045 0.5707
Trypanosoma cruzi DNA polymerase kappa, putative 0.0121 0.045 0.5707
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0009 0.0029
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0038 0.0107 0.0332
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0138 0.1754
Echinococcus multilocularis chromobox protein 1 0.0068 0.0229 0.0421
Schistosoma mansoni chromobox protein 0.0068 0.0229 0.0421
Brugia malayi hypothetical protein 0.0014 0.0009 0.0029
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0084 0.1069
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0033 0.0084 0.0155
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.003 0.0383
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0084 0.016
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.003 0.0055
Leishmania major DNA polymerase eta, putative 0.0092 0.0328 0.4166
Loa Loa (eye worm) hypothetical protein 0.0075 0.026 0.0807
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0039 0.0073
Schistosoma mansoni rab6-interacting 0.0021 0.0038 0.0069
Schistosoma mansoni terminal deoxycytidyl transferase 0.0067 0.0227 0.0416
Echinococcus granulosus solute carrier family 22 0.0014 0.0009 0.0017
Trypanosoma brucei chrX additional, unordered contigs 0.0021 0.0037 0.0464
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0031 0.0035
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0009 0.0017
Brugia malayi hypothetical protein 0.0021 0.0038 0.0117
Leishmania major DNA polymerase kappa, putative 0.0021 0.0037 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0039 0.0073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0037 0.007
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0016 0.0205
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0016 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.088 0.3564 0.6761
Trypanosoma brucei glucose transporter, putative 0.0014 0.0009 0.012
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0048 0.0148 0.0263
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0237 0.0421
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0009 0.012
Plasmodium vivax DNA repair protein REV1, putative 0.0021 0.0037 0.1088
Schistosoma mansoni microtubule-associated protein tau 0.1339 0.5447 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Plasmodium vivax hexose transporter 0.0014 0.0009 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.026 0.3295
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0055 0.0153
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0336 0.0616
Leishmania major hypothetical protein, conserved 0.0014 0.0009 0.012
Schistosoma mansoni chromobox protein 0.0068 0.0229 0.0421
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0237 0.0421
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.026 0.3295
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.003 0.0055
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0068 0.2017
Schistosoma mansoni glucose transport protein 0.0014 0.0009 0.0017
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0427 0.0759
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0009 0.0029
Trypanosoma brucei glucose transporter, putative 0.0014 0.0009 0.012
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0148 0.0263
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0383 0.0703
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0033 0.0084 0.0155
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0237 0.0435
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0034 0.0092 0.1318
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.003 0.0094
Giardia lamblia Fructose-bisphosphate aldolase 0.088 0.3564 1
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0055 0.0153
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0237 0.0421
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.045 0.5707
Brugia malayi Heterochromatin protein 1 0.0068 0.0229 0.0712
Trypanosoma brucei glucose transporter, putative 0.0014 0.0009 0.012
Mycobacterium leprae conserved hypothetical protein 0.002 0.0031 0.0056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0205
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0648 0.2611 0.4635
Schistosoma mansoni ap endonuclease 0.0038 0.0107 0.0196
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0203 0.0785 0.1441
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0059 0.0182
Schistosoma mansoni glucose transporter 0.0014 0.0009 0.0017
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0014 0.0009 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0084 0.016
Echinococcus granulosus histone lysine methyltransferase setb 0.0094 0.0336 0.0616
Loa Loa (eye worm) hypothetical protein 0.0032 0.0084 0.0262
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0009 0.0018
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.2448 1 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.003 0.0094
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0139 0.0432
Brugia malayi Muscleblind-like protein 0.0796 0.3217 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0121 0.045 0.5707
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0084 0.0262
Trypanosoma brucei unspecified product 0.0108 0.0394 0.5004
Mycobacterium ulcerans endonuclease IV 0.0075 0.0257 0.0286
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0211 0.0374
Loa Loa (eye worm) hypothetical protein 0.0796 0.3217 1
Mycobacterium ulcerans hypothetical protein 0.007 0.0237 0.0264
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0067 0.0227 0.0416
Onchocerca volvulus 0.0094 0.0338 0.1146
Plasmodium falciparum flap endonuclease 1 0.0025 0.0055 0.2121
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.045 0.5707
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0094
Onchocerca volvulus 0.0014 0.0009 0.0032
Schistosoma mansoni cpg binding protein 0.01 0.036 0.066
Echinococcus multilocularis geminin 0.0179 0.0687 0.1261
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.003 0.1173
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0016 0.0232
Loa Loa (eye worm) hypothetical protein 0.0171 0.0652 0.2028
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0177 0.0678 0.1245
Echinococcus multilocularis microtubule associated protein 2 0.1339 0.5447 1
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.1035 0.4199 0.4674
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0068 0.019
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0009 0.0018
Brugia malayi glutaminase DH11.1 0.0293 0.1153 0.3585
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0081 0.0282 0.3578
Trypanosoma brucei glucose transporter, putative 0.0014 0.0009 0.012
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0009 0.0018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0237 0.0435
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0383 0.0726
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0167 0.0518
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0014 0.0009 0.0017
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0204 0.0788 1
Echinococcus multilocularis muscleblind protein 1 0.0796 0.3217 0.5906
Trypanosoma brucei DNA polymerase IV, putative 0.0121 0.045 0.5707
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0359 0.0659
Loa Loa (eye worm) hypothetical protein 0.0021 0.0038 0.0117
Toxoplasma gondii exonuclease III APE 0.0038 0.0107 0.1531
Echinococcus granulosus mixed lineage leukemia protein mll 0.0027 0.0061 0.0112
Mycobacterium tuberculosis Probable reductase 0.0104 0.038 0.0674
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0237 0.045
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Echinococcus granulosus geminin 0.0179 0.0687 0.1261
Echinococcus multilocularis cpg binding protein 0.01 0.036 0.066
Leishmania major glucose transporter/membrane transporter D2, putative 0.0014 0.0009 0.012
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0237 0.0264
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0016 0.005
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0126 0.047 0.0862
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.003 0.0432
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0038 0.0069
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0009 0.0017
Mycobacterium ulcerans DNA polymerase IV 0.0121 0.045 0.05
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0048 0.0148 0.0132
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Trypanosoma brucei glucose transporter, putative 0.0014 0.0009 0.012
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0048 0.0148 0.0165
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0019 0.0034
Trypanosoma brucei glucose transporter, putative 0.0014 0.0009 0.012
Echinococcus granulosus transcription factor Dp 1 0.0118 0.0435 0.0799
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0237 0.0421
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0016 0.0628
Mycobacterium tuberculosis Conserved protein 0.007 0.0237 0.0421
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0383 0.486
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Mycobacterium ulcerans epimerase 0.002 0.0031 0.0035
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0336 0.4817
Loa Loa (eye worm) CXXC zinc finger family protein 0.0094 0.0338 0.1049
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0211 0.0387
Brugia malayi beta-lactamase family protein 0.007 0.0237 0.0737
Trypanosoma brucei sugar transporter, putative 0.0014 0.0009 0.012
Echinococcus multilocularis dna polymerase kappa 0.0121 0.045 0.0825
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0196 0.2492
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0177 0.0678 0.1204
Brugia malayi phosphofructokinase 0.0105 0.0383 0.119
Brugia malayi Sugar transporter family protein 0.0014 0.0009 0.0029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0359 0.1115
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0081 0.1031
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0177 0.0678 0.1245
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0752 0.3036 0.338
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0121 0.045 0.0853
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0148 0.1882
Schistosoma mansoni cpg binding protein 0.0094 0.0338 0.062
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0107 0.0119
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0204 0.0788 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0196 0.2492
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.088 0.3564 0.6761
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0177 0.0678 0.0755
Mycobacterium leprae conserved hypothetical protein 0.007 0.0237 0.0421
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.1296 0.5271 0.9357
Leishmania major DNA polymerase eta, putative 0.0046 0.0138 0.1754
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0107 0.3179
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) 0.0013 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0018
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0204 0.0788 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0107 0.0299
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0014 0.0009 0.0017
Echinococcus granulosus pyruvate kinase 0.0032 0.0084 0.0155
Trypanosoma cruzi DNA damage repair protein, putative 0.0021 0.0037 0.0464
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.038 0.0674
Echinococcus multilocularis expressed protein 0.0032 0.0084 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0039 0.0073
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0383 0.119
Echinococcus granulosus solute carrier family 22 0.0014 0.0009 0.0017
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0048 0.0148 0.4416
Schistosoma mansoni loxhd1 0.0021 0.0038 0.0069
Loa Loa (eye worm) glutaminase 0.0293 0.1153 0.3585
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0383 0.1074
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.043 0.1716 0.191
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.038 0.0674
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0038 0.0117
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0068 0.0128
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.003 0.0055
Schistosoma mansoni hypothetical protein 0.0021 0.0038 0.0069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0016 0.0481
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0383 0.0367
Treponema pallidum penicillin-binding protein (pbp-2) 0.1296 0.5271 0.5264
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Onchocerca volvulus Putative transporter 0.0014 0.0009 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0037 0.0464
Schistosoma mansoni sugar transporter 0.0014 0.0009 0.0017
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0009 0.012
Trypanosoma brucei DNA damage repair protein, putative 0.0021 0.0037 0.0464
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.1384 0.5633 1
Schistosoma mansoni hypothetical protein 0.0179 0.0687 0.1261
Onchocerca volvulus 0.003 0.0073 0.0249
Loa Loa (eye worm) hypothetical protein 0.007 0.0237 0.0737
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0039 0.0073
Schistosoma mansoni lamin 0.0026 0.0059 0.0108
Onchocerca volvulus 0.0014 0.0009 0.0032
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0084 0.016
Mycobacterium ulcerans beta-lactamase 0.007 0.0237 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0018
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0016 0.0205
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0003 0.0005
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.003 0.0094
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0107 0.0091
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0068 0.2635
Schistosoma mansoni DNA helicase recq5 0.0019 0.003 0.0055
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.003 0.0073 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0039 0.0073
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0167 0.0518
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0119 0.0225
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0019 0.006
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0107 0.0363
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.003 0.0094
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0009 0.0135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.088 0.3564 0.6761
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0359 0.1115
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0204 0.0788 0.2449
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0068 0.0128
Echinococcus granulosus chromobox protein 1 0.0068 0.0229 0.0421
Echinococcus granulosus dna polymerase kappa 0.0121 0.045 0.0825
Echinococcus granulosus dnaJ subfamily B 0.091 0.3686 0.6768
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0154 0.0584 0.1036
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0211 0.0387
Loa Loa (eye worm) histone methyltransferase 0.0033 0.0084 0.0263
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0107 0.0189
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0415 0.1656 0.2939
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0044 0.0083
Echinococcus granulosus pyruvate kinase 0.0017 0.0019 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0084 0.0262
Brugia malayi CHD4 protein 0.0016 0.0019 0.0058
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.043 0.1716 0.3046
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0107 0.0332
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.045 0.5707
Toxoplasma gondii thioredoxin reductase 0.0046 0.0139 0.1993
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0084 0.1069
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0014 0.0009 0.0017
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0084 0.1069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.088 0.3564 0.6761
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0016 0.0205
Schistosoma mansoni flap endonuclease-1 0.0023 0.0045 0.0082
Leishmania major glucose transporter, lmgt2 0.0014 0.0009 0.012
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0068 0.0128
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.0257 0.0799
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.22 0.8983 1
Brugia malayi intermediate filament protein 0.0026 0.0059 0.0182
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.003 0.1173
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.1384 0.5633 1
Echinococcus multilocularis transcription factor Dp 1 0.0118 0.0435 0.0799
Brugia malayi major facilitator superfamily protein 0.0014 0.0009 0.0029
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0098 0.0306
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0383 0.0726
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0282 0.3578
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0061 0.0112
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0084 0.016
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0177 0.0678 0.0755
Echinococcus granulosus solute carrier family 22 0.0014 0.0009 0.0017
Echinococcus multilocularis GPCR, family 2 0.0017 0.0019 0.0035
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0383 0.068
Brugia malayi Sugar transporter family protein 0.0014 0.0009 0.0029
Mycobacterium tuberculosis Conserved protein 0.007 0.0237 0.0421
Plasmodium vivax sugar transporter, putative 0.0014 0.0009 0.0281
Loa Loa (eye worm) glutathione reductase 0.0046 0.0139 0.0432
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0055 0.01
Trypanosoma brucei DNA polymerase eta, putative 0.0092 0.0328 0.4166
Onchocerca volvulus 0.0014 0.0009 0.0032
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0059 0.0182
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0084 0.2507
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.003 0.0055
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0205
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Echinococcus multilocularis neuropeptide receptor A26 0.0452 0.1806 0.3316
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Loa Loa (eye worm) sugar transporter 0.0014 0.0009 0.0029
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0107 0.0202
Loa Loa (eye worm) beta-lactamase 0.007 0.0237 0.0737
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.003 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.088 0.3564 0.6761
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0037 0.0464
Plasmodium falciparum glutathione reductase 0.0016 0.0016 0.0628
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0205
Brugia malayi 6-phosphofructokinase 0.0105 0.0383 0.119
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0084 0.0262
Schistosoma mansoni rab6-interacting 0.0021 0.0038 0.0069
Entamoeba histolytica deoxycytidyl transferase, putative 0.0067 0.0227 0.0636
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0016 0.0045
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0229 0.0435
Brugia malayi major facilitator superfamily protein 0.0014 0.0009 0.0029
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0204 0.0788 0.1446
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.088 0.3564 1
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.1035 0.4199 0.7454
Onchocerca volvulus 0.0014 0.0009 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0039 0.0073
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0081 0.0282 0.05
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0044 0.0123
Trypanosoma cruzi DNA damage repair protein, putative 0.0021 0.0037 0.0464
Toxoplasma gondii sugar transporter ST1 0.0014 0.0009 0.0135
Leishmania major glucose transporter, lmgt1 0.0014 0.0009 0.012
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0205
Echinococcus multilocularis solute carrier family 22 0.0014 0.0009 0.0017
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.038 0.0674
Trichomonas vaginalis glutaminase, putative 0.0293 0.1153 0.2188
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.003 0.0085
Echinococcus granulosus flap endonuclease 1 0.0025 0.0055 0.01
Onchocerca volvulus 0.0014 0.0009 0.0032
Onchocerca volvulus 0.0014 0.0009 0.0032
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0427 0.0759
Onchocerca volvulus 0.0014 0.0009 0.0032
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0081 0.1165
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0037 0.0464
Schistosoma mansoni glucose transport protein 0.0014 0.0009 0.0017
Leishmania major phosphopantetheinyl transferase-like protein 0.0048 0.0148 0.1882
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0055 0.0692
Plasmodium falciparum thioredoxin reductase 0.0016 0.0016 0.0628
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0105 0.0381 0.07
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0009 0.012
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0154 0.0584 0.1036
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.045 0.5707
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0035
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0009 0.0367
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0107 0.0196
Echinococcus granulosus neuropeptide s receptor 0.0452 0.1806 0.3316
Trypanosoma brucei THT1 - hexose transporter, putative 0.0014 0.0009 0.012
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.043 0.1716 0.3046
Brugia malayi Pre-SET motif family protein 0.0094 0.0336 0.1044
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0038 0.0069
Schistosoma mansoni cpg binding protein 0.01 0.036 0.066
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0067 0.0227 0.0416
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0019 0.0577
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0019 0.0035
Onchocerca volvulus 0.0014 0.0009 0.0032
Brugia malayi hypothetical protein 0.0014 0.0009 0.0029
Mycobacterium ulcerans penicillin-binding protein PbpA 0.1384 0.5633 0.6271
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0107 0.0332
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0021 0.0037 0.0524
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0139 0.0255
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0237 0.301
Schistosoma mansoni DNA polymerase IV / kappa 0.0021 0.0037 0.0067
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0171 0.0652 0.2028
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0038 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0084 0.016
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0094 0.0336 0.1044
Brugia malayi ImpB/MucB/SamB family protein 0.0092 0.0328 0.102
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0016 0.0205
Echinococcus multilocularis solute carrier family 22 0.0014 0.0009 0.0017
Onchocerca volvulus 0.0014 0.0009 0.0032
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0136
Mycobacterium tuberculosis Conserved hypothetical protein 0.0067 0.0227 0.0402
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0204 0.0788 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0018
Schistosoma mansoni intermediate filament proteins 0.0026 0.0059 0.0108
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0027 0.0061 0.0112
Schistosoma mansoni lamin 0.0026 0.0059 0.0108
Echinococcus multilocularis pyruvate kinase 0.0032 0.0084 0.0155
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0139 0.1763
Echinococcus multilocularis pyruvate kinase 0.0026 0.0056 0.0103
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0084 0.0149
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0165 0.0629 0.1956
Trypanosoma cruzi DNA polymerase eta, putative 0.0092 0.0328 0.4166
Onchocerca volvulus 0.0014 0.0009 0.0032
Loa Loa (eye worm) glutaminase 2 0.0293 0.1153 0.3585
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.1296 0.5271 0.5868
Schistosoma mansoni sugar transporter 0.0014 0.0009 0.0017
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0084 0.0149
Brugia malayi glutathione reductase 0.0046 0.0139 0.0432
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0055 0.0103
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0383 0.119
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0039 0.0073
Echinococcus granulosus pyruvate kinase 0.0017 0.0019 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0018
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0016 0.0031
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0229 0.0435
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Treponema pallidum penicillin-binding protein (pbp-3) 0.2355 0.9616 0.9615
Schistosoma mansoni lipoxygenase 0.0088 0.0314 0.0576
Treponema pallidum fructose-bisphosphate aldolase 0.088 0.3564 0.3554
Schistosoma mansoni glutaminase 0.0293 0.1153 0.2117
Loa Loa (eye worm) sugar transporter 0.0014 0.0009 0.0029
Loa Loa (eye worm) hypothetical protein 0.007 0.0237 0.0737
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0229 0.0712
Echinococcus granulosus muscleblind protein 0.0796 0.3217 0.5906
Brugia malayi Pre-SET motif family protein 0.0641 0.2583 0.803
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0237 0.301
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0196 0.2492
Loa Loa (eye worm) hypothetical protein 0.0075 0.0257 0.0799
Schistosoma mansoni ap endonuclease 0.0038 0.0107 0.0196
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0048 0.0148 0.2127
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0019 0.0035
Schistosoma mansoni pyruvate kinase 0.0032 0.0084 0.0155
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0171 0.0652 0.1198
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0084 0.0286
Echinococcus granulosus L aminoadipate semialdehyde 0.0171 0.0652 0.1198
Brugia malayi Doublecortin family protein 0.0021 0.0038 0.0117
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0039 0.0073
Echinococcus multilocularis lamin dm0 0.0026 0.0059 0.0108
Mycobacterium ulcerans sugar transporter 0.0014 0.0009 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0039 0.0073
Mycobacterium ulcerans hypothetical protein 0.002 0.0031 0.0035
Onchocerca volvulus 0.0021 0.0038 0.0128
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0211 0.0235
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0383 0.0703
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0068 0.2635
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0237 0.0737
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0014 0.0009 0.0017
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0009 0.0027
Trypanosoma cruzi hexose transporter 0.0014 0.0009 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0018
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0752 0.3036 0.539
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0016 0.003
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0177 0.0678 0.2109
Echinococcus multilocularis RUN 0.0021 0.0038 0.0069
Trypanosoma brucei trypanothione reductase 0.0046 0.0139 0.1763
Trypanosoma brucei THT1 - hexose transporter, putative 0.0014 0.0009 0.012
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0009 0.0017
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0126 0.047 0.0862
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0067 0.0227 0.0416
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0016 0.0018
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0048 0.0148 0.2127
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0016 0.0205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0336 0.0616
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0055 0.0782
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0107 0.0203
Echinococcus multilocularis pyruvate kinase 0.0017 0.0019 0.0036
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0038 0.0069
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0019 0.0754
Loa Loa (eye worm) hypothetical protein 0.0092 0.0328 0.102
Plasmodium vivax hypothetical protein, conserved 0.007 0.0237 0.7062
Loa Loa (eye worm) hypothetical protein 0.007 0.0237 0.0737
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0383 0.0426
Brugia malayi Flap endonuclease-1 0.0025 0.0055 0.0169
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0019 0.0058
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0009 0.012
Schistosoma mansoni lipoxygenase 0.0126 0.047 0.0862
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0237 0.045
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0427 0.0759
Echinococcus granulosus RUN 0.0021 0.0038 0.0069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0257 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0019 0.006
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0031 0.0107
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0016 0.003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0081 0.1031
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0427 0.0759
Loa Loa (eye worm) hypothetical protein 0.0021 0.0038 0.0117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0336 0.0616
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.045 0.5707
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0084 0.0262
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0648 0.2611 0.4635
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.002 0.0037
Chlamydia trachomatis endonuclease IV 0.0075 0.0257 0.0241
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0383 0.486
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0084 0.016
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0061 0.0116
Echinococcus multilocularis dnaJ subfamily B 0.091 0.3686 0.6768
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0038 0.1469
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0306
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0107 0.1355
Giardia lamblia Pyruvate kinase 0.0017 0.0019 0.0054
Leishmania major trypanothione reductase 0.0046 0.0139 0.1763
Brugia malayi Sugar transporter family protein 0.0014 0.0009 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0359 0.0659
Brugia malayi CXXC zinc finger family protein 0.0094 0.0338 0.1049
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0084 0.0262
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0205
Onchocerca volvulus 0.0014 0.0009 0.0032
Leishmania major pyruvate kinase 0.0032 0.0084 0.1069
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0205
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0359 0.0659
Onchocerca volvulus 0.0159 0.0605 0.2053
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0068 0.0128
Schistosoma mansoni DNA polymerase eta 0.0092 0.0328 0.0603
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0044 0.0136
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0038 0.1124
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0107 0.1355
Echinococcus granulosus cpg binding protein 0.01 0.036 0.066
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Onchocerca volvulus 0.0026 0.0059 0.0199
Schistosoma mansoni hypothetical protein 0.091 0.3686 0.6768
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0068 0.019
Plasmodium vivax SET domain protein, putative 0.0094 0.0336 1
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.0257 0.0456
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0237 0.0737
Mycobacterium ulcerans lipase LipD 0.007 0.0237 0.0264
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0139 0.0247
Toxoplasma gondii sugar transporter ST2 0.0014 0.0009 0.0135
Echinococcus multilocularis pyruvate kinase 0.0017 0.0019 0.0036
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0009 0.0018
Echinococcus multilocularis L aminoadipate semialdehyde 0.0171 0.0652 0.1198
Loa Loa (eye worm) hypothetical protein 0.007 0.0237 0.0737
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0383 0.0703
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0204 0.0788 0.1446
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0059 0.0182
Echinococcus granulosus pyruvate kinase 0.0032 0.0084 0.0155
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0019 0.006
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Onchocerca volvulus 0.0026 0.0059 0.0199
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0237 0.045
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0055 0.0169
Echinococcus multilocularis musashi 0.0026 0.0059 0.0108
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0009 0.012
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0009 0.001
Trypanosoma brucei DNA damage repair protein, putative 0.0021 0.0037 0.0464
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0359 0.0659
Schistosoma mansoni polycystin 1-related 0.0021 0.0038 0.0069
Trichomonas vaginalis rotamase, putative 0.0032 0.0081 0.0154
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.006
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0119 0.0225
Onchocerca volvulus 0.007 0.0237 0.0805
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0068 0.0052
Echinococcus granulosus lamin dm0 0.0026 0.0059 0.0108
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0083 0.0258
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0383 0.486
Echinococcus multilocularis dna polymerase eta 0.0092 0.0328 0.0603
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0237 0.045
Trypanosoma brucei unspecified product 0.0046 0.0141 0.179
Leishmania major pyruvate kinase 0.0032 0.0084 0.1069
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0061 0.0116
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0094 0.0336 0.0616
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0237 0.045
Echinococcus granulosus expressed protein 0.0032 0.0084 0.0155
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0211 0.0387
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0107 0.4154
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0009
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0009 0.012
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.003 0.0057
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0009 0.0018
Onchocerca volvulus 0.0021 0.0038 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0048 0.0148 0.0148
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0061 0.0112
Echinococcus multilocularis neuropeptide s receptor 0.0452 0.1806 0.3316
Trichomonas vaginalis esterase, putative 0.007 0.0237 0.045
Echinococcus multilocularis bloom syndrome protein 0.0019 0.003 0.0055
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0177 0.0678 0.1245
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0182
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0211 0.0235
Giardia lamblia Hexose transporter 0.0014 0.0009 0.0026
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0237 0.301
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0211 0.0387
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0211 0.3024
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0014 0.0009 0.0017
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0081 0.0228
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0081 0.1031
Treponema pallidum hypothetical protein 0.0154 0.0584 0.0568
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.003 0.0432
Echinococcus multilocularis muscleblind protein 0.0796 0.3217 0.5906
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.045 0.5707
Loa Loa (eye worm) hypothetical protein 0.007 0.0237 0.0737
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.045 0.5707
Trypanosoma brucei glucose transporter 1E 0.0014 0.0009 0.012
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0237 0.0421
Echinococcus granulosus lamin 0.0026 0.0059 0.0108
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0019 0.0034
Mycobacterium ulcerans DNA polymerase IV 0.0121 0.045 0.05
Echinococcus multilocularis pyruvate kinase 0.0032 0.0084 0.0155
Echinococcus granulosus neuropeptide receptor A26 0.0452 0.1806 0.3316
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0854 0.3458 0.6349
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0009 0.0017
Toxoplasma gondii histone lysine methyltransferase SET1 0.0182 0.0697 1
Onchocerca volvulus 0.0014 0.0009 0.0032
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0009 0.001
Trypanosoma brucei glucose transporter 2A 0.0014 0.0009 0.012
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.088 0.3564 1
Onchocerca volvulus 0.0014 0.0009 0.0032
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0019 0.0278
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0035
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.038 0.0674
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0068 0.0128
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0383 0.068
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0038 0.0069
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0067 0.0227 0.0704
Plasmodium falciparum pyruvate kinase 0.0032 0.0084 0.3276
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0009 0.0029
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0009 0.0017
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0016 0.0205
Trypanosoma brucei DNA polymerase IV, putative 0.0121 0.045 0.5707
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0084 0.0286
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Trypanosoma brucei unspecified product 0.0046 0.0141 0.179
Echinococcus granulosus dna polymerase eta 0.0092 0.0328 0.0603
Loa Loa (eye worm) hypothetical protein 0.0159 0.0605 0.188
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Brugia malayi hypothetical protein 0.0159 0.0605 0.188
Brugia malayi hypothetical protein 0.0014 0.0009 0.0029
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0016 0.0018
Chlamydia trachomatis pyruvate kinase 0.0032 0.0084 0.0068
Trichomonas vaginalis rotamase, putative 0.0032 0.0084 0.016
Giardia lamblia Pyruvate kinase 0.0032 0.0084 0.0236
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0048 0.0148 0.0165
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0016 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0107 0.0203
Toxoplasma gondii sugar transporter ST3 0.0014 0.0009 0.0135
Giardia lamblia Sugar-proton symporter 0.0014 0.0009 0.0026
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0081 0.1031
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0205
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0016 0.0018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0167 0.0518
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.003 0.0383
Onchocerca volvulus 0.007 0.0237 0.0805
Plasmodium vivax glutathione reductase, putative 0.0046 0.0139 0.4137
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0084 0.0286
Giardia lamblia DINP protein human, muc B family 0.0081 0.0282 0.0791
Entamoeba histolytica recQ family helicase, putative 0.0019 0.003 0.0085
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0046 0.0138 0.1983
Echinococcus granulosus bloom syndrome protein 0.0019 0.003 0.0055
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0139 0.0255
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.003 0.0057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0359 0.0659
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0084 0.0094
Onchocerca volvulus 0.007 0.0237 0.0805
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.045 0.5707
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0336 0.0616
Plasmodium falciparum hexose transporter 0.0014 0.0009 0.0367
Echinococcus granulosus intermediate filament protein 0.0026 0.0059 0.0108
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.038 0.0674
Trypanosoma brucei THT1 - hexose transporter, putative 0.0014 0.0009 0.012
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.038 0.0674
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0084 0.016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.088 0.3564 0.6761
Leishmania major DNA damage repair protein, putative 0.0021 0.0037 0.0464
Loa Loa (eye worm) hypothetical protein 0.0053 0.0167 0.0518
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0009 0.0017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0019 0.0035
Loa Loa (eye worm) hypothetical protein 0.0796 0.3217 1
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0009 0.001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0119 0.0403
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0014 0.0009 0.0017
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0016 0.0232
Entamoeba histolytica hypothetical protein 0.0048 0.0148 0.0416
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0084 0.1208
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0359 0.0659
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0383 0.0726
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0139 0.4137
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0237 0.0421
Leishmania major DNA polymerase kappa, putative 0.0081 0.0282 0.3578
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0061 0.0112
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0003 0.0005
Echinococcus granulosus pyruvate kinase 0.0017 0.0019 0.0036
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0383 0.0703
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Schistosoma mansoni DNA helicase recq1 0.0019 0.003 0.0055
Mycobacterium ulcerans hypothetical protein 0.0021 0.0037 0.0041
Brugia malayi SET domain containing protein 0.0017 0.0019 0.0059
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0313 0.0576
Trichomonas vaginalis DNA polymerase eta, putative 0.0121 0.045 0.0853
Echinococcus granulosus Solute carrier family 22 5 0.1002 0.4063 0.746
Echinococcus multilocularis pyruvate kinase 0.0017 0.0019 0.0036
Brugia malayi beta-lactamase 0.007 0.0237 0.0737
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0009 0.0029
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0019 0.0034
Trypanosoma brucei glucose transporter, putative 0.0014 0.0009 0.012
Onchocerca volvulus 0.0105 0.0381 0.1295
Echinococcus granulosus chromobox protein 1 0.0068 0.0229 0.0421
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0009 0.012
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0068 0.0971
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0098
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0084 0.016
Plasmodium falciparum DNA repair protein REV1, putative 0.0021 0.0037 0.1422
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.003 0.0383
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0211 0.0235
Onchocerca volvulus 0.0014 0.0009 0.0032
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0107 0.1355
Schistosoma mansoni hypothetical protein 0.0036 0.0098 0.0181
Brugia malayi polk-prov protein 0.0075 0.026 0.0807
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0068 0.0128
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0107 0.1355
Trypanosoma brucei DNA polymerase IV, putative 0.0108 0.0394 0.5004
Plasmodium falciparum thioredoxin reductase 0.0046 0.0139 0.5406
Echinococcus granulosus microtubule associated protein 2 0.1339 0.5447 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0019 0.0035
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0014 0.0009 0.0017
Giardia lamblia DNA damage repair protein 0.0021 0.0037 0.0103
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0084 0.016
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0009 0.0027
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0068 0.0128
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0383 0.1074
Schistosoma mansoni pyruvate kinase 0.0017 0.0019 0.0036
Schistosoma mansoni hypothetical protein 0.0014 0.0009 0.0017
Brugia malayi beta-lactamase family protein 0.007 0.0237 0.0737
Echinococcus multilocularis solute carrier family 22 0.0014 0.0009 0.0017
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0016 0.0205
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0204 0.0788 0.221
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0107 0.0196
Toxoplasma gondii endonuclease IV APN 0.0075 0.0257 0.3686
Leishmania major hypothetical protein, conserved 0.007 0.0237 0.301
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0016 0.0031
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0016 0.0628
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0068 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0084 0.016
Toxoplasma gondii ABC1 family protein 0.007 0.0237 0.3402
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0383 0.119
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0018
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0445 0.1779 0.3158
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0048 0.0148 0.5771
Onchocerca volvulus 0.0729 0.2945 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0068 0.0971
Trichomonas vaginalis helicase, putative 0.0021 0.0039 0.0073
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0383 0.1074
Brugia malayi 6-phosphofructokinase 0.0105 0.0383 0.119
Loa Loa (eye worm) RecQ helicase 0.0019 0.003 0.0094
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0068 0.0052
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0204 0.0788 0.2449
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0068 0.0971
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.088 0.3564 0.6761
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0009 0.0029
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0029
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0237 0.0435
Mycobacterium leprae Probable lipase LipE 0.007 0.0237 0.0421
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0383 0.0726
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0044 0.0083
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.007 0.0237 0.0737
Schistosoma mansoni hypothetical protein 0.0179 0.0687 0.1261
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0016 0.0205
Onchocerca volvulus 0.0014 0.0009 0.0032

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 32 ug ml-1 Minimum inhibitory concentration to inhibit 90 to 100% visible growth of Candida albicans ChEMBL. 12565963
MIC (functional) = 32 ug ml-1 Minimum inhibitory concentration to inhibit 90 to 100% visible growth of Candida albicans ChEMBL. 12565963
MIC (functional) > 128 ug ml-1 Minimum inhibitory concentration required to inhibit 90 to 100% visible growth of Candida glabrata ChEMBL. 12565963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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