TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 397.222 | Formula: C19H13BrN2O3
H donors: 1 H acceptors: 3 LogP: 4.24 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2nc(cc(c2cc1c1cnco1)O)c1ccc(cc1)Br
InChi: 1S/C19H13BrN2O3/c1-24-18-8-16-13(6-14(18)19-9-21-10-25-19)17(23)7-15(22-16)11-2-4-12(20)5-3-11/h2-10H,1H3,(H,22,23)
InChiKey: KZHIIZNQJMPKSE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	IMP (inosine 5'-monophosphate) dehydrogenase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania braziliensis	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania major	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma congolense	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania major	guanosine monophosphate reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania infantum	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania mexicana	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium berghei	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium yoelii	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Theileria parva	Inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania donovani	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium knowlesi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	Get druggable targets OG5_126887	All targets in OG5_126887
Neospora caninum	hypothetical protein	Get druggable targets OG5_126887	All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei gambiense	inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Toxoplasma gondii	IMP dehydrogenas	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	N terminus of Inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania infantum	guanosine monophosphate reductase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Schistosoma japonicum	ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania braziliensis	guanosine monophosphate reductase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Babesia bovis	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Cryptosporidium hominis	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Loa Loa (eye worm)	IMP dehydrogenase 1	Get druggable targets OG5_126887	All targets in OG5_126887
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	guanosine nucleotide biosynthesis	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	guanosine nucleotide biosynthesis	Get druggable targets OG5_126887	All targets in OG5_126887
Cryptosporidium parvum	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	N terminus of Inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei gambiense	inosine-5-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania donovani	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania mexicana	guanosine monophosphate reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	Get druggable targets OG5_126887	All targets in OG5_126887

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0827	0.1796
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0089	0.3282	0.7303
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0539	0.0526
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0827	0.1621
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0018	0.0512	0.1492
Loa Loa (eye worm)	hypothetical protein	0.001	0.0186	0.0164
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0008	0.0106	0.018
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0047	0.1641	0.2283
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0061	0.2182	0.3049
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0008	0.0106	0.0082
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0119	0.4448	0.8952
Brugia malayi	Peroxidasin	0.0058	0.2069	0.2096
Brugia malayi	acetyltransferase, GNAT family protein	0.016	0.6044	0.6174
Giardia lamblia	Rrm3p helicase	0.0028	0.0897	0.5954
Brugia malayi	Blistered cuticle protein 3	0.0058	0.2069	0.2096
Brugia malayi	phosphofructokinase	0.012	0.4484	0.4574
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0008	0.0106	0.018
Schistosoma mansoni	hypothetical protein	0.0187	0.7099	1
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.0336	0.0695
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0018	0.0512	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2069	0.2096
Mycobacterium tuberculosis	Probable dehydrogenase	0.0119	0.4448	0.8952
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0336	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2069	0.2096
Leishmania major	guanosine monophosphate reductase	0.0095	0.3501	0.7796
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0032	0.107	0.2387
Brugia malayi	hypothetical protein	0.0022	0.0655	0.0645
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0028	0.0897	0.2
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0008	0.0106	0.018
Onchocerca volvulus		0.0058	0.2069	0.2048
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0008	0.0106	0.018
Brugia malayi	GMP reductase	0.0039	0.1342	0.135
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0008	0.0106	0.0304
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0132	0.4966	1
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0095	0.3501	0.7796
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0052	0.1842	0.2567
Echinococcus granulosus	protein jagged 1	0.0019	0.0538	0.0723
Entamoeba histolytica	hypothetical protein, conserved	0.0028	0.0897	0.2
Echinococcus multilocularis	protein jagged 1	0.0019	0.0538	0.0723
Loa Loa (eye worm)	animal heme peroxidase	0.0058	0.2069	0.2096
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0047	0.1641	0.1612
Loa Loa (eye worm)	hypothetical protein	0.002	0.0569	0.0557
Giardia lamblia	Exonuclease 1	0.0006	0.0035	0.0057
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0095	0.3501	0.7796
Onchocerca volvulus		0.0008	0.0106	0.008
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.016	0.6044	0.8509
Entamoeba histolytica	exonuclease, putative	0.0006	0.0035	0.0077
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0827	0.0822
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0007	0.0065	0.0078
Echinococcus granulosus	neurogenic locus notch protein	0.0019	0.0538	0.0723
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0827	0.1796
Brugia malayi	Bloom's syndrome protein homolog	0.0024	0.0725	0.0717
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0008	0.0106	0.0304
Brugia malayi	6-phosphofructokinase	0.012	0.4484	0.4574
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0095	0.3501	0.7796
Entamoeba histolytica	hypothetical protein	0.004	0.1355	0.3022
Toxoplasma gondii	6-phosphofructokinase	0.0032	0.107	0.3057
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0106	0.0082
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0106	0.0082
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0028	0.0897	0.1231
Schistosoma mansoni	xp-G/rad2 DNA repair endonuclease family	0.0006	0.0035	0.0012
Toxoplasma gondii	CBS domain-containing protein	0.0006	0.0026	0.0075
Schistosoma mansoni	hypothetical protein	0.0019	0.0538	0.0723
Echinococcus granulosus	peroxidasin	0.0058	0.2069	0.2889
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0095	0.3501	0.3565
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0019	0.0538	0.0723
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0008	0.0106	0.0113
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0297	0.0608
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0013	0.0325	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2069	0.2096
Entamoeba histolytica	acetyltransferase, GNAT family	0.0043	0.1488	0.3319
Echinococcus multilocularis	neurogenic locus protein delta	0.0019	0.0538	0.0723
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0028	0.0897	0.1953
Mycobacterium tuberculosis	Probable oxidoreductase	0.0132	0.4966	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0512	0.1089
Plasmodium vivax	6-phosphofructokinase, putative	0.0032	0.107	0.3247
Onchocerca volvulus		0.0026	0.0827	0.0803
Brugia malayi	Animal haem peroxidase family protein	0.0058	0.2069	0.2096
Schistosoma mansoni	lipoxygenase	0.0061	0.2182	0.3049
Toxoplasma gondii	XPG N-terminal domain-containing protein	0.0006	0.0035	0.0099
Loa Loa (eye worm)	XPG I-region family protein	0.0006	0.0035	0.0009
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.1091	0.1506
Loa Loa (eye worm)	hypothetical protein	0.002	0.0569	0.0557
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0028	0.0897	0.1953
Loa Loa (eye worm)	animal heme peroxidase	0.0058	0.2069	0.2096
Brugia malayi	XPG I-region family protein	0.0006	0.0035	0.0009
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.012	0.4484	1
Trypanosoma cruzi	GMP reductase	0.0095	0.3501	0.7796
Onchocerca volvulus	Peroxidase homolog	0.0058	0.2069	0.2048
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0029	0.0927	0.2022
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.0186	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Echinococcus multilocularis	6 phosphofructokinase	0.012	0.4484	0.6303
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.107	0.104
Toxoplasma gondii	propionate-CoA ligase	0.0008	0.0106	0.0304
Trichomonas vaginalis	DNA helicase recq1, putative	0.0024	0.0725	0.0693
Onchocerca volvulus	Peroxidasin homolog	0.0058	0.2069	0.2048
Brugia malayi	EGF-like domain containing protein	0.0019	0.0538	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0827	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2069	0.2096
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0827	0.0822
Brugia malayi	Thioredoxin reductase	0.0052	0.1842	0.1862
Onchocerca volvulus		0.0019	0.0538	0.0513
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0512	0.1089
Brugia malayi	Calcium binding EGF domain containing protein	0.0019	0.0538	0.0525
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0827	0.1796
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0095	0.3501	0.4914
Mycobacterium ulcerans	acyl-CoA synthetase	0.0008	0.0106	0.018
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0008	0.0106	0.0162
Trypanosoma brucei	GMP reductase	0.0095	0.3501	0.7796
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0018	0.0512	0.1089
Brugia malayi	Flap endonuclease-1	0.0029	0.0927	0.0925
Brugia malayi	6-phosphofructokinase	0.012	0.4484	0.4574
Onchocerca volvulus	Peroxidase homolog	0.0058	0.2069	0.2048
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.107	0.104
Mycobacterium ulcerans	acyl-CoA synthetase	0.0008	0.0106	0.018
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Mycobacterium ulcerans	acyl-CoA synthetase	0.0008	0.0106	0.018
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.0186	0.0226
Brugia malayi	EGF-like domain containing protein	0.0019	0.0538	0.0525
Leishmania major	acetyl-CoA synthetase, putative	0.0008	0.0106	0.018
Schistosoma mansoni	notch	0.0019	0.0538	0.0723
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.1091	0.1506
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0186	0.0164
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0008	0.0106	0.0162
Schistosoma mansoni	hypothetical protein	0.004	0.1355	0.1879
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.005	0.1747	0.3483
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0005	0.0007	0.002
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0512	0.1089
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0569	0.5199
Loa Loa (eye worm)	hypothetical protein	0.002	0.0569	0.0557
Plasmodium vivax	SET domain protein, putative	0.0033	0.1091	0.3311
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0106	0.0162
Trichomonas vaginalis	glutathione reductase, putative	0.0018	0.0512	0.0479
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0008	0.0106	0.018
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.1044	0.1439
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2069	0.2096
Brugia malayi	Animal haem peroxidase family protein	0.0058	0.2069	0.2096
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0018	0.0512	0.0498
Brugia malayi	hypothetical protein	0.0058	0.2069	0.2096
Entamoeba histolytica	DNA-repair protein, putative	0.0006	0.0035	0.0077
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0008	0.0106	0.0162
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0095	0.3501	0.4914
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0512	0.1089
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0018	0.0512	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0028	0.0897	0.1953
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0106	0.0082
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0018	0.0512	0.1089
Entamoeba histolytica	hypothetical protein	0.004	0.1355	0.3022
Trichomonas vaginalis	flap endonuclease-1, putative	0.0029	0.0927	0.0896
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0106	0.0072
Loa Loa (eye worm)	CYP4Cod1	0.0014	0.0336	0.0318
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0018	0.0512	0.0687
Plasmodium vivax	DNA repair protein RAD2, putative	0.0006	0.0035	0.0085
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0018	0.0512	0.1542
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.107	0.104
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.016	0.6044	0.8509
Schistosoma mansoni	notch	0.0019	0.0538	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2069	0.2096
Brugia malayi	glutathione reductase	0.0052	0.1842	0.1862
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0569	0.1099
Loa Loa (eye worm)	glutathione reductase	0.0052	0.1842	0.1862
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0032	0.107	0.2342
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0008	0.0106	0.0162
Echinococcus granulosus	slit 2 protein	0.0019	0.0538	0.0723
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.1355	0.1879
Brugia malayi	Animal haem peroxidase family protein	0.0058	0.2069	0.2096
Echinococcus multilocularis	exonuclease 1	0.0006	0.0035	0.0012
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0028	0.0897	0.1953
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0018	0.0512	0.0687
Echinococcus granulosus	protein jagged 2	0.0019	0.0538	0.0723
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0527	0.1015
Trichomonas vaginalis	phosphofructokinase, putative	0.012	0.4484	0.4465
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0095	0.3501	0.4914
Brugia malayi	Delta serrate ligand family protein	0.0019	0.0538	0.0525
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0018	0.0512	0.0983
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0019	0.0538	0.0513
Toxoplasma gondii	NADPH-glutathione reductase	0.0018	0.0512	0.1462
Brugia malayi	Cadherin domain containing protein	0.0019	0.0538	0.0525
Onchocerca volvulus		0.0022	0.0655	0.0631
Entamoeba histolytica	hypothetical protein	0.004	0.1355	0.3022
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0336	0.0318
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.023	0.8763	0.8963
Brugia malayi	notch-like transmembrane receptor	0.0019	0.0538	0.0525
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0106	0.0082
Schistosoma mansoni	septate junction protein	0.0019	0.0538	0.0723
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0018	0.0512	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2069	0.2096
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Mycobacterium ulcerans	acyl-CoA synthetase	0.0008	0.0106	0.018
Echinococcus granulosus	Polycystic kidney disease protein	0.0022	0.0655	0.0889
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0008	0.0106	0.0304
Echinococcus granulosus	protein jagged 1	0.0019	0.0538	0.0723
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0008	0.0106	0.018
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0029	0.0927	0.2022
Mycobacterium ulcerans	acyl-CoA synthetase	0.0008	0.0106	0.018
Echinococcus granulosus	flap endonuclease 1	0.0029	0.0927	0.1274
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.0089	0.3282	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0018	0.0512	0.1089
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0018	0.0512	0.1089
Schistosoma mansoni	peroxidasin	0.0058	0.2069	0.2889
Echinococcus multilocularis	notch	0.0019	0.0538	0.0723
Echinococcus granulosus	fibropellin Ia	0.0019	0.0538	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0047	0.1641	0.4989
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0119	0.4448	0.8952
Toxoplasma gondii	chloride transporter, chloride channel (ClC) family protein	0.0006	0.0026	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0008	0.0106	0.018
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.002	0.0569	0.1218
Echinococcus multilocularis	flap endonuclease 1	0.0029	0.0927	0.1274
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0028	0.0897	0.1953
Leishmania major	trypanothione reductase	0.0052	0.1842	0.4072
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.1091	0.1506
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0018	0.0512	0.1089
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0897	0.0865
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0008	0.0106	0.018
Echinococcus granulosus	thioredoxin glutathione reductase	0.0052	0.1842	0.2567
Leishmania major	ATP-dependent phosphofructokinase	0.012	0.4484	1
Schistosoma mansoni	6-phosphofructokinase	0.012	0.4484	0.6303
Plasmodium falciparum	thioredoxin reductase	0.0018	0.0512	0.1492
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0018	0.0512	0.1542
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0827	0.1621
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.042	0.12
Schistosoma mansoni	peroxidasin	0.0058	0.2069	0.2889
Entamoeba histolytica	phosphofructokinase, putative	0.012	0.4484	1
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.0089	0.3282	1
Onchocerca volvulus		0.0019	0.0538	0.0513
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0095	0.3501	0.3565
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0018	0.0512	0.1398
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0186	0.0531
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0827	0.1796
Plasmodium vivax	thioredoxin reductase, putative	0.0052	0.1842	0.5602
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0095	0.3501	0.7796
Entamoeba histolytica	Flap nuclease, putative	0.0029	0.0927	0.2068
Echinococcus granulosus	neural cadherin	0.0019	0.0538	0.0723
Schistosoma mansoni	hypothetical protein	0.0019	0.0538	0.0723
Schistosoma mansoni	hypothetical protein	0.0022	0.0655	0.0889
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0008	0.0106	0.0162
Brugia malayi	EGF-like domain containing protein	0.0019	0.0538	0.0525
Schistosoma mansoni	DNA helicase recq1	0.001	0.0186	0.0226
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0106	0.0162
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.0655	0.0889
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0047	0.1641	0.4686
Trichomonas vaginalis	mercuric reductase, putative	0.0018	0.0512	0.0479
Echinococcus multilocularis	protein jagged 1	0.0019	0.0538	0.0723
Toxoplasma gondii	CBS domain-containing protein	0.0006	0.0026	0.0075
Brugia malayi	Pre-SET motif family protein	0.023	0.8763	0.8963
Toxoplasma gondii	CBS family protein	0.0006	0.0026	0.0075
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0614	0.1804
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.012	0.4484	1
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0032	0.107	1
Loa Loa (eye worm)	thioredoxin reductase	0.0052	0.1842	0.1862
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.012	0.4484	0.9024
Echinococcus multilocularis	neural cadherin	0.0019	0.0538	0.0723
Giardia lamblia	Sgs1 DNA helicase, putative	0.001	0.0186	0.1092
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0132	0.4966	1
Plasmodium falciparum	thioredoxin reductase	0.0052	0.1842	0.5576
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0028	0.0897	0.1231
Trichomonas vaginalis	phosphofructokinase, putative	0.012	0.4484	0.4465
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0297	0.0608
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0028	0.0897	0.1953
Trypanosoma brucei	cytochrome P450, putative	0.0014	0.0336	0.0695
Echinococcus granulosus	RUN	0.0022	0.0655	0.0889
Brugia malayi	Animal haem peroxidase family protein	0.0058	0.2069	0.2096
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.0336	0.0695
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.1091	0.1506
Onchocerca volvulus		0.0033	0.1091	0.1068
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0106	0.0082
Toxoplasma gondii	XPG N-terminal domain-containing protein	0.0006	0.0035	0.0099
Entamoeba histolytica	phosphofructokinase, putative	0.012	0.4484	1
Brugia malayi	Doublecortin family protein	0.0022	0.0655	0.0645
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0008	0.0106	0.018
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0095	0.3501	0.7796
Schistosoma mansoni	DNA helicase recq5	0.001	0.0186	0.0226
Plasmodium vivax	6-phosphofructokinase, putative	0.0032	0.107	0.3247
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2069	0.2096
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0106	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0827	0.1844
Brugia malayi	Animal haem peroxidase family protein	0.0058	0.2069	0.2096
Loa Loa (eye worm)	notch protein	0.0019	0.0538	0.0525
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0032	0.107	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.0058	0.2069	0.2096
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.0569	0.1717
Echinococcus granulosus	notch	0.0019	0.0538	0.0723
Mycobacterium ulcerans	acyl-CoA synthetase	0.0008	0.0106	0.018
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Schistosoma mansoni	hypothetical protein	0.0028	0.0897	0.1231
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0014	0.0336	0.0695
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.107	0.104
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.0655	0.0889
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.1091	0.1506
Loa Loa (eye worm)	6-phosphofructokinase	0.012	0.4484	0.4574
Entamoeba histolytica	exonuclease, putative	0.0006	0.0035	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.0186	0.0164
Loa Loa (eye worm)	6-phosphofructokinase	0.012	0.4484	0.4574
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0008	0.0106	0.018
Schistosoma mansoni	loxhd1	0.0022	0.0655	0.0889
Toxoplasma gondii	XPG N-terminal domain-containing protein	0.0006	0.0035	0.0099
Schistosoma mansoni	notch	0.0019	0.0538	0.0723
Schistosoma mansoni	flap endonuclease-1	0.0026	0.082	0.1122
Onchocerca volvulus		0.0008	0.0106	0.008
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0106	0.0162
Loa Loa (eye worm)	animal heme peroxidase	0.0058	0.2069	0.2096
Onchocerca volvulus	Neurogenic locus notch homolog	0.0019	0.0538	0.0513
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.0655	0.0889
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0039	0.1342	0.135
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0035	0.0009
Leishmania major	acetyl-CoA synthetase, putative	0.0008	0.0106	0.018
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0018	0.0512	0.1398
Trypanosoma brucei	DNA repair protein RAD2, putative	0.0006	0.0035	0.0019
Schistosoma mansoni	hypothetical protein	0.0187	0.7099	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.1091	0.1506
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0019	0.0538	0.0723
Echinococcus multilocularis	protein jagged 2	0.0019	0.0538	0.0723
Schistosoma mansoni	slit	0.0019	0.0538	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0827	0.0822
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0827	0.1796
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.107	0.104
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0032	0.107	0.7143
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0032	0.107	0.3207
Echinococcus multilocularis	fibropellin Ia	0.0019	0.0538	0.0723
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0019	0.0538	0.0525
Onchocerca volvulus		0.0019	0.0538	0.0513
Toxoplasma gondii	thioredoxin reductase	0.0052	0.1842	0.5259
Echinococcus granulosus	neurogenic locus notch protein 4	0.0019	0.0538	0.0723
Toxoplasma gondii	IMP dehydrogenas	0.0095	0.3501	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0043	0.1488	0.449
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0047	0.1641	0.4686
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0827	0.1844
Echinococcus granulosus	geminin	0.0187	0.7099	1
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.012	0.4484	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.1355	0.1879
Trypanosoma cruzi	DNA repair protein RAD2, putative	0.0006	0.0035	0.0019
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0018	0.0512	0.1089
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0336	0.0318
Schistosoma mansoni	exonuclease	0.0006	0.0035	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Echinococcus multilocularis	geminin	0.0187	0.7099	1
Giardia lamblia	High cysteine protein	0.0019	0.0538	0.3499
Brugia malayi	EGF-like domain containing protein	0.0019	0.0538	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Loa Loa (eye worm)	animal heme peroxidase	0.0058	0.2069	0.2096
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0527	0.1015
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0008	0.0106	0.018
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0827	0.1844
Onchocerca volvulus		0.0022	0.0655	0.0631
Schistosoma mansoni	hypothetical protein	0.0019	0.0538	0.0723
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0095	0.3501	0.7035
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0018	0.0512	0.1089
Echinococcus granulosus	bloom syndrome protein	0.0024	0.0725	0.0988
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0095	0.3501	0.7796
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0186	0.0531
Echinococcus granulosus	delta-like protein 1	0.0019	0.0538	0.0723
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0095	0.3501	1
Onchocerca volvulus	Chorion peroxidase homolog	0.0058	0.2069	0.2048
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0061	0.2182	0.3049
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0119	0.4448	0.8952
Onchocerca volvulus		0.0058	0.2069	0.2048
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0029	0.0927	0.2649
Entamoeba histolytica	phosphofructokinase, putative	0.012	0.4484	1
Echinococcus multilocularis	RUN	0.0022	0.0655	0.0889
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0827	0.1796
Trypanosoma cruzi	hypothetical protein, conserved	0.0006	0.0035	0.0019
Brugia malayi	hypothetical protein	0.0022	0.0655	0.0645
Brugia malayi	EGF-like domain containing protein	0.0019	0.0538	0.0525
Echinococcus multilocularis	DNA repair protein complementing XP G cells	0.0006	0.0035	0.0012
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.0569	0.1667
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.0532	0.0715
Mycobacterium ulcerans	acyl-CoA synthetase	0.0008	0.0106	0.018
Trypanosoma cruzi	GMP reductase	0.0095	0.3501	0.7796
Onchocerca volvulus		0.0019	0.0538	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0106	0.0082
Plasmodium vivax	glutathione reductase, putative	0.0052	0.1842	0.5602
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0018	0.0512	0.3322
Echinococcus granulosus	exonuclease 1	0.0006	0.0035	0.0012
Onchocerca volvulus		0.0008	0.0106	0.008
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.012	0.4484	0.9024
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0155	0.5869	0.8261
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0008	0.0106	0.018
Trichomonas vaginalis	DNA helicase recq, putative	0.0013	0.0297	0.0264
Onchocerca volvulus	Dual oxidase homolog	0.0058	0.2069	0.2048
Schistosoma mansoni	rab6-interacting	0.0022	0.0655	0.0889
Echinococcus granulosus	protein jagged 2	0.0019	0.0538	0.0723
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0827	0.1796
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0018	0.0512	0.4651
Trypanosoma brucei	trypanothione reductase	0.0052	0.1842	0.4072
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0047	0.1641	0.1612
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0827	0.0822
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0827	0.1796
Schistosoma mansoni	polycystin 1-related	0.0022	0.0655	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2069	0.2096
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.1091	0.1506
Schistosoma mansoni	cell polarity protein	0.0019	0.0538	0.0723
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.0045	0.1562	0.3108
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.0655	0.0889
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0008	0.0106	0.018
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0018	0.0512	0.1462
Trichomonas vaginalis	DNA helicase recq, putative	0.0024	0.0725	0.0693
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.1355	0.1879
Echinococcus multilocularis	flap endonuclease GEN 1	0.0006	0.0035	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0827	0.0822
Trypanosoma cruzi	trypanothione reductase, putative	0.0018	0.0512	0.1089
Toxoplasma gondii	phosphofructokinase PFKII	0.0032	0.107	0.3057
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0827	0.1796
Trichomonas vaginalis	set domain proteins, putative	0.0261	1	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0106	0.0082
Loa Loa (eye worm)	Notch2	0.0019	0.0538	0.0525
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0019	0.0538	0.0723
Brugia malayi	follicle stimulating hormone receptor	0.0256	0.9773	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0827	0.1796
Mycobacterium ulcerans	6-phosphofructokinase	0.012	0.4484	1
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0008	0.0106	0.0246
Schistosoma mansoni	laminin gamma-3 chain	0.0019	0.0538	0.0723
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0008	0.0106	0.0082
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0052	0.1842	0.3675
Brugia malayi	hypothetical protein	0.004	0.1355	0.1363
Echinococcus granulosus	6 phosphofructokinase	0.012	0.4484	0.6303
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.001	0.0186	0.049
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0106	0.0082
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0045	0.1562	0.3444
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0186	0.0164
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0827	0.1621
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.005	0.1747	0.3483
Onchocerca volvulus	Putative GMP reductase	0.0039	0.1342	0.1319
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0032	0.107	0.3057
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0033	0.1091	0.1093
Echinococcus granulosus	flap endonuclease GEN 1	0.0006	0.0035	0.0012
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0018	0.0512	0.1492
Echinococcus granulosus	neurogenic locus notch protein	0.0019	0.0538	0.0723
Onchocerca volvulus		0.0008	0.0106	0.008
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0032	0.107	0.104
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0008	0.0106	0.018
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0016	0.0428	0.1285
Plasmodium falciparum	LCCL domain-containing protein	0.0022	0.0655	0.1932
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0029	0.0927	0.2022
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0018	0.0512	0.1089
Giardia lamblia	Histone acetyltransferase GCN5	0.0043	0.1488	1
Plasmodium falciparum	DNA repair protein RAD2, putative	0.0006	0.0035	0.0026
Echinococcus granulosus	neurogenic locus protein delta	0.0019	0.0538	0.0723
Trypanosoma cruzi	hypothetical protein, conserved	0.0006	0.0035	0.0019
Toxoplasma gondii	EGF family domain-containing protein	0.0019	0.0538	0.1536
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0512	0.1089
Brugia malayi	EGF-like domain containing protein	0.0019	0.0538	0.0525
Schistosoma mansoni	notch	0.0019	0.0538	0.0723
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0095	0.3501	0.7035
Loa Loa (eye worm)	acetyltransferase	0.016	0.6044	0.6174
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2069	0.2096
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0013	0.0325	0.0306
Loa Loa (eye worm)	doublecortin family protein	0.0022	0.0655	0.0645
Plasmodium falciparum	glutathione reductase	0.0052	0.1842	0.5576
Loa Loa (eye worm)	RecQ helicase	0.0024	0.0725	0.0717
Trichomonas vaginalis	phosphofructokinase, putative	0.012	0.4484	0.4465
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2069	0.2096
Echinococcus multilocularis	neurogenic locus notch protein	0.0019	0.0538	0.0723
Schistosoma mansoni	6-phosphofructokinase	0.012	0.4484	0.6303
Schistosoma mansoni	hypothetical protein	0.0019	0.0538	0.0723
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0028	0.0897	0.1953
Trypanosoma brucei	exonuclease, putative	0.0006	0.0035	0.0019
Schistosoma mansoni	hypothetical protein	0.0019	0.0538	0.0723
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0512	0.1089
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0039	0.1342	0.135
Plasmodium falciparum	glutathione reductase	0.0018	0.0512	0.1492
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Schistosoma mansoni	notch	0.0019	0.0538	0.0723
Echinococcus granulosus	DNA repair protein complementing XP G cells	0.0006	0.0035	0.0012
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0008	0.0106	0.0082
Mycobacterium ulcerans	acyl-CoA synthetase	0.0008	0.0106	0.018
Loa Loa (eye worm)	phosphofructokinase	0.012	0.4484	0.4574
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0336	0.0318
Plasmodium vivax	multidomain scavenger receptor, putative	0.0022	0.0655	0.198
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0655	0.0645
Echinococcus multilocularis	slit 2 protein	0.0019	0.0538	0.0723
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0018	0.0512	0.1089
Plasmodium falciparum	flap endonuclease 1	0.0029	0.0927	0.2768
Loa Loa (eye worm)	hypothetical protein	0.001	0.0184	0.0162
Brugia malayi	Cadherin domain containing protein	0.0019	0.0538	0.0525
Schistosoma mansoni	lipoxygenase	0.0022	0.0655	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2069	0.2096
Plasmodium falciparum	exonuclease I, putative	0.0006	0.0035	0.0026
Echinococcus multilocularis	Polycystic kidney disease protein	0.0022	0.0655	0.0889
Onchocerca volvulus	Slit protein homolog	0.0019	0.0538	0.0513
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0527	0.1015
Loa Loa (eye worm)	hypothetical protein	0.002	0.0569	0.0557
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0119	0.4448	0.8952
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0008	0.0106	0.0237
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.0186	0.0226
Leishmania major	hypothetical protein, conserved	0.0006	0.0035	0.0019
Brugia malayi	GCC2 and GCC3 family protein	0.0019	0.0538	0.0525
Onchocerca volvulus		0.0058	0.2069	0.2048
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0008	0.0106	0.018
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0018	0.0512	0.1089
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0008	0.0106	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Entamoeba histolytica	recQ family helicase, putative	0.0013	0.0297	0.0663
Schistosoma mansoni	hypothetical protein	0.0019	0.0538	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Brugia malayi	Calcium binding EGF domain containing protein	0.0019	0.0538	0.0525
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0008	0.0106	0.0162
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0008	0.0106	0.0162
Schistosoma mansoni	notch	0.0019	0.0538	0.0723
Echinococcus multilocularis	bloom syndrome protein	0.0024	0.0725	0.0988
Onchocerca volvulus	Putative cubilin	0.0019	0.0538	0.0513
Schistosoma mansoni	hypothetical protein	0.0019	0.0538	0.0723
Treponema pallidum	NADH oxidase	0.0018	0.0512	0.1089
Echinococcus multilocularis	neurogenic locus protein delta	0.0019	0.0538	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0655	0.0645
Toxoplasma gondii	XPG N-terminal domain-containing protein	0.0006	0.0035	0.0099
Schistosoma mansoni	acetyl-CoA synthetase	0.0008	0.0106	0.0113
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0827	0.1796
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0032	0.107	0.3207
Plasmodium vivax	exonuclease I, putative	0.0006	0.0035	0.0085
Brugia malayi	Muscle positioning protein 4	0.0019	0.0538	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Schistosoma mansoni	xp-G/rad2 DNA repair endonuclease family member	0.0006	0.0035	0.0012
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0132	0.4966	1
Trypanosoma cruzi	DNA repair protein RAD2, putative	0.0006	0.0035	0.0019
Brugia malayi	Pre-SET motif family protein	0.0033	0.1091	0.1093
Plasmodium vivax	flap endonuclease 1, putative	0.0029	0.0927	0.2811
Giardia lamblia	Flap structure-specific endonuclease	0.0029	0.0927	0.6165
Leishmania major	cytochrome p450-like protein	0.0014	0.0336	0.0695
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0256	0.9773	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0527	0.1015
Onchocerca volvulus	Peroxidasin homolog	0.0058	0.2069	0.2048
Mycobacterium tuberculosis	Probable reductase	0.0119	0.4448	0.8952
Trichomonas vaginalis	phosphofructokinase, putative	0.012	0.4484	0.4465
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0538	0.0525
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0018	0.0512	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2069	0.2096
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0297	0.0608
Brugia malayi	Calcium binding EGF domain containing protein	0.0019	0.0538	0.0525
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0827	0.1621
Entamoeba histolytica	hypothetical protein	0.004	0.1355	0.3022
Loa Loa (eye worm)	flap endonuclease-1	0.0029	0.0927	0.0925
Loa Loa (eye worm)	hypothetical protein	0.002	0.0569	0.0557
Giardia lamblia	hypothetical protein	0.0006	0.0035	0.0057
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0106	0.0162
Echinococcus multilocularis	peroxidasin	0.0058	0.2069	0.2889
Onchocerca volvulus		0.0019	0.0538	0.0513
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0008	0.0106	0.0162
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.0186	0.0226
Brugia malayi	EGF-like domain containing protein	0.0019	0.0538	0.0525
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.1091	0.3117
Echinococcus multilocularis	neurogenic locus notch protein	0.0019	0.0538	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2069	0.2096
Schistosoma mansoni	rab6-interacting	0.0022	0.0655	0.0889
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0008	0.0106	0.018
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0119	0.4448	0.8952
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0035	0.0009
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0008	0.0106	0.0162
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.107	0.104
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0008	0.0106	0.0162
Loa Loa (eye worm)	GMP reductase	0.0039	0.1342	0.135
Trypanosoma cruzi	trypanothione reductase, putative	0.0052	0.1842	0.4072

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.005 uM	Inhibition of human inosine monophosphate dehydrogenase IMPDH II	ChEMBL.	12565968
IC50 (binding)	= 0.005 uM	Inhibition of human inosine monophosphate dehydrogenase IMPDH II	ChEMBL.	12565968

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 262085