Detailed information for compound 269786

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.952 | Formula: C21H33ClN2O2
  • H donors: 1 H acceptors: 2 LogP: 4.05 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@H](N([C@H](CC)C)C[C@@H]([C@H]1CCC(=O)N1Cc1ccccc1Cl)O)C
  • InChi: 1S/C21H33ClN2O2/c1-5-15(3)23(16(4)6-2)14-20(25)19-11-12-21(26)24(19)13-17-9-7-8-10-18(17)22/h7-10,15-16,19-20,25H,5-6,11-14H2,1-4H3/t15-,16+,19-,20+/m1/s1
  • InChiKey: YNGZJSALRCLELM-GJJHYRHESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Kappa opioid receptor Starlite/ChEMBL No references
Rattus norvegicus Mu opioid receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Mitochondrial inner membrane protein homolog Kappa opioid receptor   380 aa 337 aa 25.8 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Kappa opioid receptor   380 aa 310 aa 20.0 %
Onchocerca volvulus Kappa opioid receptor   380 aa 344 aa 24.4 %
Onchocerca volvulus Programmed cell death protein 5 homolog Kappa opioid receptor   380 aa 353 aa 23.2 %
Echinococcus granulosus thyrotropin releasing hormone receptor Kappa opioid receptor   380 aa 359 aa 25.3 %
Onchocerca volvulus Mitogen-activated protein kinase kinase kinase 8 homolog Kappa opioid receptor   380 aa 384 aa 20.3 %
Echinococcus granulosus orexin receptor type 2 Kappa opioid receptor   380 aa 381 aa 23.1 %
Echinococcus granulosus neuropeptide receptor Kappa opioid receptor   380 aa 315 aa 26.0 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 332 aa 20.5 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Kappa opioid receptor   380 aa 313 aa 26.8 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   398 aa 335 aa 20.6 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Kappa opioid receptor   380 aa 352 aa 19.3 %
Brugia malayi GnHR receptor homolog Kappa opioid receptor   380 aa 345 aa 20.0 %
Echinococcus granulosus allatostatin A receptor Kappa opioid receptor   380 aa 320 aa 28.1 %
Onchocerca volvulus Kappa opioid receptor   380 aa 310 aa 25.5 %
Schistosoma mansoni rhodopsin-like orphan GPCR Kappa opioid receptor   380 aa 363 aa 22.9 %
Echinococcus granulosus growth hormone secretagogue receptor type 1 Kappa opioid receptor   380 aa 306 aa 21.2 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Kappa opioid receptor   380 aa 347 aa 22.5 %
Echinococcus multilocularis orexin receptor type 2 Kappa opioid receptor   380 aa 381 aa 22.6 %
Echinococcus multilocularis growth hormone secretagogue receptor type 1 Kappa opioid receptor   380 aa 306 aa 21.2 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Kappa opioid receptor   380 aa 408 aa 23.5 %
Onchocerca volvulus Kappa opioid receptor   380 aa 313 aa 26.8 %
Onchocerca volvulus Kappa opioid receptor   380 aa 313 aa 20.8 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 319 aa 21.9 %
Onchocerca volvulus Phospholipase d-related homolog Kappa opioid receptor   380 aa 309 aa 19.4 %
Onchocerca volvulus Kappa opioid receptor   380 aa 403 aa 26.3 %
Brugia malayi ORL1-like opioid receptor Kappa opioid receptor   380 aa 335 aa 24.5 %
Schistosoma japonicum Rhodopsin, putative Kappa opioid receptor   380 aa 352 aa 22.2 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Kappa opioid receptor   380 aa 335 aa 23.6 %
Onchocerca volvulus Phosphoinositide 3-kinase adapter subunit homolog Kappa opioid receptor   380 aa 332 aa 23.5 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Kappa opioid receptor   380 aa 387 aa 25.1 %
Echinococcus multilocularis neuropeptide receptor Kappa opioid receptor   380 aa 315 aa 26.3 %
Echinococcus multilocularis allatostatin A receptor Kappa opioid receptor   380 aa 319 aa 27.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) histone deacetylase 7A 0.003 0.0017 0.0017
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0342 0.0396 0.0396
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0002 0.0002
Echinococcus multilocularis histone deacetylase 6 0.0035 0.0022 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0002 0.0002
Echinococcus granulosus glycine receptor subunit alpha 1 0.006 0.0052 0.0383
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0025 0.0187
Onchocerca volvulus Neuropeptide F receptor homolog 0.0038 0.0025 0.2778
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0034 0.4538
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.006 0.0052 0.0383
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0033 0.4397
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.006 0.0052 0.0383
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0033 0.4397
Onchocerca volvulus 0.0043 0.0031 0.3489
Loa Loa (eye worm) hypothetical protein 0.0342 0.0396 0.0396
Brugia malayi neuropeptide F receptor 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0038 0.0025 0.0025
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.006 0.0052 0.0052
Onchocerca volvulus 0.0038 0.0025 0.2778
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0006 0.0004
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0022 0.0006 0.0004
Schistosoma mansoni phosphoglucomutase 0.0025 0.0011 0.0078
Echinococcus granulosus peptide allatostatin:somatostatin 0.0038 0.0025 0.0187
Schistosoma mansoni ap endonuclease 0.0018 0.0002 0.0015
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.006 0.0052 0.0052
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0002 0.0016
Schistosoma mansoni tyrosine kinase 0.0605 0.0717 0.5248
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0022 0.0006 0.0043
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0029 0.0678
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0002 0.0016
Trypanosoma cruzi histone deacetylase, putative 0.003 0.0017 0.0015
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.006 0.0052 0.0052
Mycobacterium tuberculosis Possible transferase 0.0022 0.0006 0.0007
Echinococcus multilocularis insulin receptor 0.036 0.0418 0.3061
Trypanosoma brucei metacaspase 5, putative 0.0045 0.0034 0.0032
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0034 0.4538
Trypanosoma brucei GDP-mannose pyrophosphorylase 0.0022 0.0006 0.0004
Trypanosoma cruzi C-8 sterol isomerase, putative 0.8224 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Mycobacterium leprae Probable lipase LipE 0.0036 0.0023 0.0031
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0006 0.0004
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0022 0.0006 0.0043
Echinococcus granulosus cpg binding protein 0.0035 0.0022 0.0159
Mycobacterium tuberculosis Conserved protein 0.0036 0.0023 0.0038
Onchocerca volvulus 0.006 0.0052 0.5972
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) carbonic anhydrase 3 0.0922 0.1102 0.1102
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0002 0.0016
Echinococcus granulosus dro:myosuppressin receptor 0.0038 0.0025 0.0187
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0922 0.1102 0.1101
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.0946 0.6929
Schistosoma mansoni hypothetical protein 0.0022 0.0006 0.0043
Echinococcus multilocularis epidermal growth factor receptor 0.1126 0.1351 0.9896
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Echinococcus granulosus glycine receptor subunit alpha 1 0.006 0.0052 0.0383
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0002 0.0016
Toxoplasma gondii GDP-D-mannose pyrophosphorylase 0.0022 0.0006 0.0038
Loa Loa (eye worm) hypothetical protein 0.0342 0.0396 0.0396
Echinococcus granulosus glycine receptor subunit alpha 1 0.006 0.0052 0.0383
Echinococcus multilocularis glycine receptor subunit beta 0.006 0.0052 0.0383
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0029 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0092 0.0092 0.0673
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Onchocerca volvulus 0.0037 0.0024 0.2653
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0002 0.0016
Echinococcus granulosus 7TM GPCR rhodopsin 0.0038 0.0025 0.0187
Mycobacterium ulcerans hypothetical protein 0.0022 0.0006 0.0007
Brugia malayi G protein-coupled receptor 0.0038 0.0025 0.0025
Schistosoma mansoni tyrosine kinase 0.0605 0.0717 0.5248
Loa Loa (eye worm) nucleotidyl transferase 0.0022 0.0006 0.0006
Echinococcus multilocularis cpg binding protein 0.0035 0.0022 0.0159
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0023 0.0008 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0023 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0002 0.0002
Trypanosoma brucei metacaspase 0.0045 0.0034 0.0032
Entamoeba histolytica serine acetyltransferase, putative 0.0022 0.0006 0.1411
Onchocerca volvulus 0.0023 0.0008 0.0641
Echinococcus multilocularis dynactin 5 p25 0.0022 0.0006 0.0043
Trichomonas vaginalis sugar-1-phosphate guanyl transferase, putative 0.0022 0.0006 0.0776
Echinococcus granulosus nAChR subunit 0.0037 0.0024 0.0179
Onchocerca volvulus 0.006 0.0052 0.5972
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0002 0.0016
Onchocerca volvulus 0.0038 0.0025 0.2778
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0037 0.0024 0.0024
Schistosoma mansoni nAChR subunit 0.006 0.0052 0.0383
Echinococcus multilocularis serotonin receptor 0.0159 0.0173 0.1268
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0033 0.0244
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0023
Echinococcus granulosus caspase 3 0.0073 0.0069 0.0502
Schistosoma mansoni carbonic anhydrase-related 0.0342 0.0396 0.29
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Schistosoma mansoni alkaline phosphatase 0.0339 0.0393 0.2878
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Echinococcus granulosus orexin receptor type 2 0.0038 0.0025 0.0187
Schistosoma mansoni nAChR subunit 0.006 0.0052 0.0383
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.4555 0.5529 1
Brugia malayi beta-lactamase 0.0036 0.0023 0.0023
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0023 0.0038
Echinococcus multilocularis dro:myosuppressin receptor 0.0038 0.0025 0.0187
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0002 0.0016
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0006 0.0004
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0038 0.0025 0.0187
Schistosoma mansoni gdp-mannose pyrophosphorylase b isoform 2 0.0022 0.0006 0.0043
Echinococcus multilocularis neuropeptide FF receptor 2 0.0038 0.0025 0.0187
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.006 0.0052 0.0052
Schistosoma mansoni carbonic anhydrase-related 0.0342 0.0396 0.29
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0002 0.0278
Mycobacterium tuberculosis Conserved protein 0.0036 0.0023 0.0038
Trypanosoma brucei ingi protein (ORF1) 0.0028 0.0013 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Echinococcus multilocularis nAChR subunit 0.006 0.0052 0.0383
Echinococcus multilocularis histone deacetylase 6 0.003 0.0017 0.0122
Brugia malayi hypothetical protein 0.0023 0.0008 0.0008
Brugia malayi hypothetical protein 0.0038 0.0025 0.0025
Brugia malayi larval opioid receptor 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0039 0.0027 0.0027
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.0162 0.1186
Echinococcus granulosus alpha 1A adrenergic receptor 0.0038 0.0025 0.0187
Schistosoma mansoni neuropeptide receptor 0.0038 0.0025 0.0187
Echinococcus multilocularis 0.0348 0.0404 0.296
Treponema pallidum licC protein (licC) 0.0835 0.0997 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.006 0.0052 0.0052
Brugia malayi Cell death protein 3 precursor 0.0087 0.0086 0.0086
Echinococcus multilocularis p2X purinoceptor 4 0.1137 0.1366 1
Onchocerca volvulus Putative nachr subunit 0.006 0.0052 0.5972
Echinococcus multilocularis mannose 1 phosphate guanyltransferase 0.0022 0.0006 0.0043
Schistosoma mansoni neuropeptide receptor 0.0038 0.0025 0.0187
Echinococcus granulosus dynactin 5 p25 0.0022 0.0006 0.0043
Schistosoma mansoni histone deacetylase 4 5 0.003 0.0017 0.0122
Schistosoma mansoni cpg binding protein 0.0035 0.0022 0.0159
Brugia malayi nuclear hormone receptor 0.0018 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0002
Echinococcus granulosus neuropeptide receptor A26 0.0038 0.0025 0.0187
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0002 0.0002
Leishmania major hypothetical protein, conserved 0.0027 0.0013 0.0011
Mycobacterium ulcerans transferase 0.0022 0.0006 0.0007
Schistosoma mansoni nAChR subunit 0.006 0.0052 0.0383
Trypanosoma brucei unspecified product 0.0028 0.0013 0.0011
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0023 0.0038
Echinococcus granulosus somatostatin receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Loa Loa (eye worm) TK/INSR protein kinase 0.036 0.0418 0.0418
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0006 0.0004
Mycobacterium tuberculosis Probable oxidoreductase 0.0229 0.0259 0.0465
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0922 0.1102 0.1102
Schistosoma mansoni hypothetical protein 0.0039 0.0027 0.0197
Onchocerca volvulus 0.0038 0.0025 0.2778
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.006 0.0052 0.0383
Mycobacterium ulcerans hypothetical protein 0.0835 0.0997 0.18
Toxoplasma gondii eukaryotic initiation factor-2B, epsilon subunit, putative 0.0022 0.0006 0.0038
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0084 0.0082 0.0082
Echinococcus multilocularis sex peptide receptor 0.0038 0.0025 0.0187
Brugia malayi hypothetical protein 0.0023 0.0008 0.0008
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0038 0.0025 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0025 0.0187
Plasmodium falciparum dynactin subunit 5, putative 0.0022 0.0006 0.0096
Entamoeba histolytica acetyltransferase, putative 0.0022 0.0006 0.1411
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0835 0.0997 0.18
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0023 0.0168
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0002 0.0016
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0034 0.4538
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0002 0.0002
Echinococcus granulosus glycine receptor subunit beta 0.006 0.0052 0.0383
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0006
Onchocerca volvulus 0.0038 0.0025 0.2778
Entamoeba histolytica acetyltransferase, putative 0.0022 0.0006 0.1411
Echinococcus multilocularis neuropeptide receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0002 0.0016
Brugia malayi hypothetical protein 0.0023 0.0008 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Brugia malayi Dopamine receptor protein 1 0.0038 0.0025 0.0025
Toxoplasma gondii hypothetical protein 0.0342 0.0396 0.3959
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0034 0.0324
Schistosoma mansoni histamine h1 receptor 0.0038 0.0025 0.0187
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0023 0.0008 0.0055
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Echinococcus granulosus neuropeptide receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0002
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.0008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Schistosoma mansoni neuropeptide receptor 0.0038 0.0025 0.0187
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0023 0.3029
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0002 0.0002
Schistosoma mansoni P2X receptor subunit 0.0526 0.0621 0.4545
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.006 0.0052 0.0383
Echinococcus multilocularis caspase 0.0118 0.0123 0.0903
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0002
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0002 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0025 0.0187
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0087 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Trypanosoma brucei RNA helicase, putative 0.0095 0.0096 0.0094
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0002 0.0016
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.006 0.0052 0.0052
Loa Loa (eye worm) melatonin receptor type 1A 0.0038 0.0025 0.0025
Echinococcus granulosus neuropeptides capa receptor 0.0038 0.0025 0.0187
Onchocerca volvulus 0.006 0.0052 0.5972
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.006 0.0052 0.0052
Trypanosoma cruzi serine acetyltransferase, putative 0.0022 0.0006 0.0004
Brugia malayi putative neuropeptide receptor 0.0038 0.0025 0.0025
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0023 0.0008 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0024
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0342 0.0396 0.0396
Brugia malayi Furin-like cysteine rich region family protein 0.1126 0.1351 0.1351
Schistosoma mansoni nAChR subunit 0.0023 0.0008 0.0055
Brugia malayi GnHR receptor homolog 0.0038 0.0025 0.0025
Schistosoma mansoni alkaline phosphatase 0.0339 0.0393 0.2878
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Leishmania major hypothetical protein, conserved 0.0022 0.0006 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0002 0.0016
Brugia malayi MH2 domain containing protein 0.0128 0.0136 0.0136
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0023 0.0008 0.0008
Echinococcus granulosus neuropeptide FF receptor 2 0.0038 0.0025 0.0187
Schistosoma mansoni hypothetical protein 0.0183 0.0202 0.1482
Schistosoma mansoni biogenic amine (5HT) receptor 0.0038 0.0025 0.0187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0025 0.0187
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0025 0.0187
Trichomonas vaginalis esterase, putative 0.0036 0.0023 0.3029
Echinococcus multilocularis neuropeptides capa receptor 0.0038 0.0025 0.0187
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0023 0.0008 0.0055
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0006 0.0007
Trypanosoma brucei histone deacetylase 4 0.003 0.0017 0.0015
Echinococcus granulosus p2X purinoceptor 4 0.1137 0.1366 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0002 0.0002
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.006 0.0052 0.0052
Schistosoma mansoni cpg binding protein 0.0035 0.0022 0.0159
Mycobacterium ulcerans short chain dehydrogenase 0.0229 0.0259 0.0465
Brugia malayi ORL1-like opioid receptor 0.0038 0.0025 0.0025
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.036 0.0418 0.3061
Loa Loa (eye worm) ACC-1 protein 0.006 0.0052 0.0052
Entamoeba histolytica ankyrin, putative 0.0022 0.0006 0.1411
Echinococcus granulosus g-protein coupled receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0064 0.047
Loa Loa (eye worm) TYRA-2 protein 0.0038 0.0025 0.0025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0035 0.0254
Echinococcus granulosus tm gpcr rhodopsin 0.0663 0.0787 0.5763
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0002 0.0002
Brugia malayi Dopamine receptor 0.0038 0.0025 0.0025
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0022 0.0006 0.0043
Trypanosoma cruzi ribonuclease H1, putative 0.0025 0.0011 0.0009
Schistosoma mansoni caspase-7 (C14 family) 0.0118 0.0123 0.0903
Brugia malayi Tachykinin-like peptides receptor 99D 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0024
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0024 0.0009 0.0069
Toxoplasma gondii ribonuclease HI protein 0.0025 0.0011 0.0086
Brugia malayi Dopamine receptor protein 2 0.0038 0.0025 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0035 0.0254
Echinococcus granulosus mannose 1 phosphate guanyltransferase 0.0022 0.0006 0.0043
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0023 0.0038
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.006 0.0052 0.0052
Schistosoma mansoni coup transcription factor 0.0018 0.0002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0043 0.0031 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0013 0.0267
Schistosoma mansoni carbonic anhydrase-related 0.0342 0.0396 0.29
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.8224 1 1
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0022 0.0006 0.0004
Echinococcus granulosus histone deacetylase 6 0.0035 0.0022 0.0163
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Brugia malayi RNase H family protein 0.0025 0.0011 0.0011
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.006 0.0052 0.0052
Echinococcus multilocularis epidermal growth factor receptor 0.0605 0.0717 0.5248
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0019 0.0019
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0034 0.0324
Echinococcus granulosus allatostatin A receptor 0.0038 0.0025 0.0187
Echinococcus granulosus g protein coupled receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0002 0.0002
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.0024 0.0024
Onchocerca volvulus 0.0038 0.0025 0.2778
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0006 0.0004
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.0162 0.0162
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0002 0.0015
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0038 0.0025 0.0187
Brugia malayi hypothetical protein 0.0022 0.0006 0.0006
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.006 0.0052 0.0383
Schistosoma mansoni amine GPCR 0.0038 0.0025 0.0187
Trypanosoma brucei metacaspase MCA3 0.0045 0.0034 0.0032
Brugia malayi Serotonin receptor 0.0038 0.0025 0.0025
Echinococcus multilocularis caspase 2 0.0087 0.0086 0.0631
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.006 0.0052 0.0383
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0023 0.6458
Leishmania major hypothetical protein, conserved 0.0022 0.0006 0.0004
Onchocerca volvulus 0.0038 0.0025 0.2778
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0035 0.0254
Toxoplasma gondii hypothetical protein 0.0022 0.0006 0.0038
Loa Loa (eye worm) acetyltransferase 0.015 0.0162 0.0162
Schistosoma mansoni amine GPCR 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0159 0.0173 0.0173
Trypanosoma cruzi Translation initiation factor eIF-2B subunit epsilon, putative 0.0022 0.0006 0.0004
Onchocerca volvulus 0.006 0.0052 0.5972
Plasmodium vivax histone deacetylase 2, putative 0.003 0.0017 0.451
Brugia malayi excitatory GABA receptor EXP-1A 0.006 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0006 0.0776
Echinococcus granulosus fmrfamide receptor 0.0038 0.0025 0.0187
Schistosoma mansoni hypothetical protein 0.0018 0.0002 0.0011
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0022 0.0006 0.1411
Echinococcus multilocularis neuropeptides capa receptor 0.0038 0.0025 0.0187
Trypanosoma brucei ingi protein (ORF1) 0.0028 0.0013 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0002 0.0002
Onchocerca volvulus 0.0038 0.0025 0.2778
Plasmodium falciparum mannose-1-phosphate guanyltransferase, putative 0.0022 0.0006 0.0096
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0024
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0045 0.0034 0.0034
Onchocerca volvulus 0.0023 0.0008 0.0641
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.006 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Echinococcus multilocularis voltage gated potassium channel 0.0024 0.0009 0.0069
Schistosoma mansoni tyrosine kinase 0.0599 0.0709 0.5191
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0002 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0035 0.0254
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.006 0.0052 0.0383
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0038 0.0025 0.0187
Echinococcus granulosus hypothetical protein 0.0038 0.0025 0.0187
Echinococcus multilocularis neuropeptide Y receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0022 0.0006 0.0006
Schistosoma mansoni neurotransmitter gated ion channel 0.0037 0.0024 0.0179
Echinococcus multilocularis GPCR, family 2 0.0018 0.0002 0.0011
Loa Loa (eye worm) ACC-1 protein 0.006 0.0052 0.0052
Onchocerca volvulus 0.0038 0.0025 0.2778
Echinococcus multilocularis allatostatin A receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0342 0.0396 0.0396
Echinococcus multilocularis glycine receptor subunit alpha 1 0.006 0.0052 0.0383
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.006 0.0578
Entamoeba histolytica serine acetyltransferase 1 0.0022 0.0006 0.1411
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Brugia malayi sulfakinin receptor protein 0.0038 0.0025 0.0025
Brugia malayi putative neuropeptide receptor NPR1 0.0038 0.0025 0.0025
Echinococcus granulosus histone deacetylase 6 0.003 0.0017 0.0122
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0027 0.0027
Schistosoma mansoni opsin-like receptor 0.0038 0.0025 0.0187
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.0157 0.1149
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.006 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0023
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0023 0.0038
Echinococcus multilocularis carbonic anhydrase 0.0342 0.0396 0.29
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.006 0.0052 0.0052
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0034 0.4538
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0034 0.4538
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0013 0.0011
Echinococcus multilocularis G-protein coupled receptor, putative 0.0038 0.0025 0.0187
Onchocerca volvulus 0.0037 0.0024 0.2653
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0008 0.0008
Echinococcus granulosus neuropeptide s receptor 0.0038 0.0025 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0009 0.0069
Brugia malayi zgc:92842 0.0022 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Plasmodium falciparum metacaspase 1 0.0045 0.0034 0.0819
Echinococcus granulosus histone deacetylase 6 0.003 0.0017 0.0122
Echinococcus multilocularis g-protein coupled receptor 0.0038 0.0025 0.0187
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0023 0.0023
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0022 0.0006 0.0006
Giardia lamblia Translation initiation factor 0.0022 0.0006 0.1411
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Plasmodium falciparum histone deacetylase 2 0.003 0.0017 0.0369
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0022 0.0006 0.0007
Onchocerca volvulus 0.006 0.0052 0.5972
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0023 0.0038
Leishmania major GDP-mannose pyrophosphorylase 0.0022 0.0006 0.0004
Schistosoma mansoni hypothetical protein 0.0038 0.0025 0.0187
Schistosoma mansoni mannose-1-phosphate guanyltransferase 0.0022 0.0006 0.0043
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0002 0.0002
Brugia malayi RE15519p 0.0038 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0038 0.0025 0.0187
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.006 0.0052 0.0052
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.006 0.0052 0.0052
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0002 0.0002
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0022 0.0006 0.0007
Brugia malayi hypothetical protein 0.0022 0.0006 0.0006
Echinococcus granulosus neuropeptide Y receptor 0.0038 0.0025 0.0187
Mycobacterium ulcerans beta-lactamase 0.0036 0.0023 0.0038
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0922 0.1102 0.1102
Plasmodium vivax histone deacetylase, putative 0.003 0.0017 0.451
Brugia malayi hypothetical protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0023
Trypanosoma brucei nucleotidyl transferase, putative 0.0022 0.0006 0.0004
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0023 0.0008 0.0008
Schistosoma mansoni nAChR subunit 0.0023 0.0008 0.0055
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0037 0.0024 0.0024
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0038 0.0025 0.0187
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.006 0.0052 0.0383
Leishmania major ribonuclease H1, putative 0.0025 0.0011 0.0009
Echinococcus granulosus carbonic anhydrase 0.0342 0.0396 0.29
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0002 0.0016
Brugia malayi RNase H family protein 0.0025 0.0011 0.0011
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0028 0.0013 0.0011
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0038 0.0025 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0023 0.3029
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0006
Echinococcus multilocularis p2X purinoceptor 4 0.1137 0.1366 1
Brugia malayi hypothetical protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0073 0.0069 0.0069
Echinococcus granulosus biogenic amine 5HT receptor 0.0038 0.0025 0.0187
Brugia malayi Nucleotidyl transferase family protein 0.0022 0.0006 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.0162 0.1186
Echinococcus granulosus serotonin receptor 0.0038 0.0025 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0034 0.4538
Mycobacterium ulcerans serine acetyltransferase CysE 0.0022 0.0006 0.0007
Loa Loa (eye worm) G-protein coupled receptor 0.0038 0.0025 0.0025
Plasmodium vivax dynactin subunit 5, putative 0.0022 0.0006 0.1168
Mycobacterium ulcerans hypothetical protein 0.0835 0.0997 0.18
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0022 0.0006 0.0043
Echinococcus granulosus alkaline phosphatase 0.0339 0.0393 0.2878
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0045 0.0034 0.0252
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Schistosoma mansoni neuropeptide f receptor 76f 0.0038 0.0025 0.0187
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.4555 0.5529 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0025 0.0187
Schistosoma mansoni hypothetical protein 0.0183 0.0202 0.1482
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0024 0.0009 0.0009
Leishmania major metacaspase, putative 0.0045 0.0034 0.0032
Onchocerca volvulus 0.0036 0.0023 0.2472
Leishmania major serine acetyltransferase 0.0022 0.0006 0.0004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0663 0.0787 0.5763
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0024
Schistosoma mansoni opsin-like receptor 0.0038 0.0025 0.0187
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0002 0.0002
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0033 0.0313
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0079 0.0076 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0002 0.0002
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0922 0.1102 0.1102
Schistosoma mansoni acetylcholine receptor subunit beta 0.0023 0.0008 0.0055
Schistosoma mansoni ap endonuclease 0.0018 0.0002 0.0015
Schistosoma mansoni tyrosine kinase 0.036 0.0418 0.3061
Echinococcus multilocularis glycine receptor subunit alpha 1 0.006 0.0052 0.0383
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0038 0.0025 0.0025
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0033 0.9667
Mycobacterium ulcerans hypothetical protein 0.0036 0.0023 0.0038
Loa Loa (eye worm) TK/EGFR protein kinase 0.1126 0.1351 0.1351
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0002
Schistosoma mansoni growth hormone secretagogue receptor 0.0038 0.0025 0.0187
Plasmodium falciparum metacaspase-like protein 0.0045 0.0034 0.0819
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0023 0.0038
Brugia malayi hypothetical protein 0.0043 0.0031 0.0031
Echinococcus granulosus ribonuclease H1 0.0025 0.0011 0.0078
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0008 0.0008
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0023 0.0168
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.006 0.0052 0.0052
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.0024 0.0024
Echinococcus granulosus neuropeptide receptor 0.0038 0.0025 0.0187
Plasmodium falciparum histone deacetylase, putative 0.003 0.0017 0.0369
Echinococcus granulosus dnaJ subfamily B 0.0466 0.0547 0.4006
Brugia malayi GDP-mannose pyrophosphorylase B 0.0022 0.0006 0.0006
Echinococcus multilocularis histone deacetylase 6 0.003 0.0017 0.0122
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.006 0.0052 0.0052
Plasmodium falciparum liver specific protein 2, putative 0.0022 0.0006 0.0096
Plasmodium vivax metacaspase 1, putative 0.0045 0.0034 1
Trypanosoma brucei histone deacetylase, putative 0.003 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0002
Brugia malayi CXXC zinc finger family protein 0.0033 0.0019 0.0019
Brugia malayi Serotonin receptor 0.0495 0.0583 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0034 0.4538
Trypanosoma cruzi metacaspase, putative 0.0045 0.0034 0.0032
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0002 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0035 0.0254
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Brugia malayi beta-lactamase family protein 0.0036 0.0023 0.0023
Brugia malayi G-protein coupled receptor 0.0038 0.0025 0.0025
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0342 0.0396 0.0396
Brugia malayi hypothetical protein 0.0038 0.0025 0.0025
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0339 0.0393 0.2878
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0006 0.0004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0034 0.4538
Schistosoma mansoni voltage-gated potassium channel 0.0092 0.0092 0.0673
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0002 0.0002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0038 0.0025 0.0187
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Brugia malayi neuropeptide F receptor 0.0038 0.0025 0.0025
Echinococcus granulosus neuropeptides capa receptor 0.0038 0.0025 0.0187
Echinococcus multilocularis fmrfamide receptor 0.0038 0.0025 0.0187
Onchocerca volvulus 0.0038 0.0025 0.2778
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0002 0.0278
Brugia malayi Cation transporter family protein 0.006 0.0052 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0118 0.0123 0.0903
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0038 0.0025 0.0187
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Trypanosoma brucei C-8 sterol isomerase, putative 0.8224 1 1
Brugia malayi follicle stimulating hormone receptor 0.0038 0.0025 0.0025
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.006 0.0052 0.0383
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.0006 0.0096
Echinococcus multilocularis histone deacetylase 7 0.003 0.0017 0.0122
Loa Loa (eye worm) hypothetical protein 0.0057 0.0049 0.0049
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.006 0.0052 0.0052
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0002 0.0002
Schistosoma mansoni histone deacetylase 4 5 0.003 0.0017 0.0122
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.006 0.0052 0.0052
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0033 0.0313
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0023 0.0038
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0002 0.0016
Chlamydia trachomatis acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase 0.0022 0.0006 0.5
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.006 0.0052 0.0383
Loa Loa (eye worm) LGC-31 protein 0.006 0.0052 0.0052
Loa Loa (eye worm) histone deacetylase 0.003 0.0017 0.0017
Entamoeba histolytica acetyltransferase, putative 0.0022 0.0006 0.1411
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0038 0.0025 0.0025
Schistosoma mansoni phosphoglucomutase 0.0025 0.0011 0.0078
Onchocerca volvulus 0.0036 0.0023 0.2472
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0038 0.0025 0.0025
Mycobacterium tuberculosis Possible siderophore-binding protein 0.0022 0.0006 0.0007
Loa Loa (eye worm) G-protein coupled receptor 0.0038 0.0025 0.0025
Echinococcus granulosus geminin 0.0183 0.0202 0.1482
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0002 0.0002
Mycobacterium ulcerans lipase LipD 0.0036 0.0023 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0002 0.0011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0159 0.0173 0.1268
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0342 0.0396 0.0396
Onchocerca volvulus 0.0038 0.0025 0.2778
Brugia malayi Cation transporter family protein 0.006 0.0052 0.0052
Onchocerca volvulus Cell death protein 3 homolog 0.0087 0.0086 1
Echinococcus multilocularis neuropeptide s receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0002 0.0016
Loa Loa (eye worm) GABA receptor subunit 0.0037 0.0024 0.0024
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0038 0.0025 0.0187
Echinococcus granulosus g protein coupled receptor 0.0038 0.0025 0.0187
Plasmodium falciparum carbonic anhydrase 0.0342 0.0396 1
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0023 0.0008 0.0008
Schistosoma mansoni neuropeptide F-like receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Brugia malayi Protein kinase domain containing protein 0.036 0.0418 0.0418
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.0024 0.0179
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0013 0.0011
Echinococcus multilocularis serotonin receptor 0.0159 0.0173 0.1268
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0035 0.0254
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0002 0.0016
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.0136 0.0136
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0023 0.0031
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0339 0.0393 0.2878
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0023 0.0021
Schistosoma mansoni tyrosine kinase 0.036 0.0418 0.3061
Loa Loa (eye worm) neuropeptide F receptor 0.0038 0.0025 0.0025
Trichomonas vaginalis ribonuclease H1, putative 0.0025 0.0011 0.1409
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0339 0.0393 0.2878
Echinococcus granulosus carbonic anhydrase II 0.0922 0.1102 0.8073
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Echinococcus multilocularis orexin receptor type 2 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0022 0.0006 0.0776
Brugia malayi hypothetical protein 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0159 0.0173 0.0173
Onchocerca volvulus 0.0036 0.0023 0.2472
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0034 0.0324
Schistosoma mansoni cpg binding protein 0.0033 0.0019 0.0143
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0023 0.0008 0.0055
Echinococcus multilocularis carbonic anhydrase 0.0342 0.0396 0.29
Brugia malayi hypothetical protein 0.0023 0.0008 0.0008
Echinococcus multilocularis somatostatin receptor 0.0038 0.0025 0.0187
Plasmodium vivax mannose-1-phosphate guanyltransferase, putative 0.0022 0.0006 0.1168
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0023 0.0038
Echinococcus granulosus histone deacetylase 7 0.003 0.0017 0.0122
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0605 0.0717 0.5248
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0034 0.4538
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0038 0.0025 0.0187
Entamoeba histolytica serine acetyltransferase 1 0.0022 0.0006 0.1411
Entamoeba histolytica hypothetical protein 0.0037 0.0024 0.8364
Echinococcus granulosus biogenic amine 5HT receptor 0.0159 0.0173 0.1268
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.0256 0.046
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0031 0.0231
Leishmania major hypothetical protein, conserved 0.0022 0.0006 0.0004
Schistosoma mansoni glucosamine-1-phosphate N-acetyltransferase 0.0022 0.0006 0.0043
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0009 0.0069
Entamoeba histolytica maltose O-acetyltransferase, putative 0.0022 0.0006 0.1411
Trypanosoma cruzi serine acetyltransferase, putative 0.0022 0.0006 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0035 0.0254
Leishmania major histone deacetylase, putative 0.003 0.0017 0.0015
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0024 0.0009 0.0069
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0922 0.1102 0.1101
Brugia malayi hypothetical protein 0.0038 0.0025 0.0025
Echinococcus multilocularis ribonuclease H1 0.0025 0.0011 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0002 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0002 0.0002
Schistosoma mansoni biogenic amine receptor 0.0038 0.0025 0.0187
Trypanosoma cruzi hypothetical protein 0.0022 0.0006 0.0004
Echinococcus granulosus sex peptide receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0922 0.1102 0.8073
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.0008 0.0055
Echinococcus granulosus epidermal growth factor receptor 0.0605 0.0717 0.5248
Schistosoma mansoni hypothetical protein 0.0095 0.0096 0.0702
Echinococcus granulosus tm gpcr rhodopsin 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0035 0.0035
Onchocerca volvulus 0.0038 0.0025 0.2778
Schistosoma mansoni adenoreceptor 0.0038 0.0025 0.0187
Entamoeba histolytica acetyltransferase, putative 0.0022 0.0006 0.1411
Brugia malayi hypothetical protein 0.0038 0.0025 0.0025
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.006 0.0052 0.0383
Onchocerca volvulus 0.0038 0.0025 0.2778
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0342 0.0396 0.0396
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0038 0.0025 0.0187
Schistosoma mansoni nAChR subunit 0.006 0.0052 0.0383
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0038 0.0025 0.0187
Echinococcus multilocularis neuropeptide receptor A26 0.0038 0.0025 0.0187
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Schistosoma mansoni histone deacetylase hda2 0.0035 0.0022 0.0163
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0002
Echinococcus multilocularis carbonic anhydrase 0.0342 0.0396 0.29
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0025 0.0187
Schistosoma mansoni myosin xvIII 0.0038 0.0025 0.0187
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0038 0.0025 0.0025
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.006 0.0052 0.0383
Wolbachia endosymbiont of Brugia malayi carbonic anhydrase 0.0022 0.0006 0.0007
Echinococcus granulosus caspase 0.0118 0.0123 0.0903
Onchocerca volvulus 0.0038 0.0025 0.2778
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0835 0.0997 1
Echinococcus granulosus p2X purinoceptor 4 0.1137 0.1366 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0008 0.0008
Brugia malayi eIF4-gamma/eIF5/eIF2-epsilon family protein 0.0022 0.0006 0.0006
Trypanosoma cruzi histone deacetylase, putative 0.003 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0466 0.0547 0.4006
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0034 1
Brugia malayi hypothetical protein 0.0038 0.0025 0.0025
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0038 0.0025 0.0187
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0038 0.0025 0.0187
Echinococcus multilocularis caspase 3 0.0073 0.0069 0.0502
Schistosoma mansoni amine GPCR 0.0038 0.0025 0.0187
Trypanosoma brucei Metacaspase-4 0.0045 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Trypanosoma cruzi ribonuclease H1, putative 0.0025 0.0011 0.0009
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.006 0.0052 0.0383
Echinococcus granulosus intestinal type alkaline phosphatase 0.0339 0.0393 0.2878
Schistosoma mansoni caspase-7 (C14 family) 0.0087 0.0086 0.0631
Schistosoma mansoni opsin-like receptor 0.0038 0.0025 0.0187
Echinococcus granulosus p2X purinoceptor 4 0.1137 0.1366 1
Echinococcus granulosus epidermal growth factor receptor 0.1126 0.1351 0.9896
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0022 0.0006 0.0043
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0013 0.0011
Leishmania major hypothetical protein, conserved 0.0036 0.0023 0.0021
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0038 0.0025 0.0187
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0018 0.0002 0.0011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0035 0.0035
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0038 0.0025 0.0187
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0002 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Echinococcus granulosus tachykinin peptides receptor 99D 0.0038 0.0025 0.0187
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0034 0.4538
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0002 0.0016
Echinococcus granulosus caspase 8 0.0045 0.0034 0.0252
Schistosoma mansoni tyrosine kinase 0.0599 0.0709 0.5191
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0339 0.0393 0.2878
Echinococcus granulosus G protein coupled receptor 139 0.0038 0.0025 0.0187
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0023 0.0021
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0002 0.0002
Schistosoma mansoni carbonic anhydrase 0.0342 0.0396 0.29
Brugia malayi hypothetical protein 0.0038 0.0025 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.006 0.0052 0.0383
Echinococcus granulosus insulin receptor 0.036 0.0418 0.3061
Brugia malayi Histone deacetylase family protein 0.003 0.0017 0.0017
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0023
Schistosoma mansoni biogenic amine receptor 0.0038 0.0025 0.0187
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0002 0.0016
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0079 0.0076 1
Onchocerca volvulus 0.0033 0.0019 0.2063
Giardia lamblia Ribonuclease H 0.0025 0.0011 0.3205
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.006 0.0052 0.0052
Echinococcus multilocularis carbonic anhydrase II 0.0922 0.1102 0.8073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0034 0.4538
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0049 0.0049
Brugia malayi hypothetical protein 0.0023 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.4555 0.5529 1
Entamoeba histolytica acetyltransferase, putative 0.0022 0.0006 0.1411
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0084 0.0082 0.0604
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0023 0.3029
Treponema pallidum ribonuclease H (rnhA) 0.0025 0.0011 0.0086
Schistosoma mansoni nAChR subunit 0.006 0.0052 0.0383
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0342 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0045 0.0034 0.0034
Echinococcus multilocularis glycine receptor subunit beta 0.006 0.0052 0.0383
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0002 0.0011
Echinococcus granulosus glycine receptor subunit beta 0.006 0.0052 0.0383
Schistosoma mansoni P2X receptor subunit 0.1137 0.1366 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0025 0.0187
Echinococcus multilocularis geminin 0.0183 0.0202 0.1482
Toxoplasma gondii histone deacetylase HDAC1 0.003 0.0017 0.0146
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0023
Brugia malayi ecdysteroid receptor 0.0018 0.0002 0.0002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0002 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Schistosoma mansoni neuropeptide F-like receptor 0.0038 0.0025 0.0187
Mycobacterium ulcerans d-alpha-D-mannose-1-phosphate guanylyltransferase ManB 0.0022 0.0006 0.0007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0002 0.0016
Trypanosoma brucei histone deacetylase 3 0.003 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Onchocerca volvulus 0.0023 0.0008 0.0641
Leishmania major histone deacetylase, putative 0.003 0.0017 0.0015
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0038 0.0025 0.0025
Echinococcus granulosus insulin growth factor 1 receptor beta 0.036 0.0418 0.3061
Toxoplasma gondii ABC1 family protein 0.0036 0.0023 0.0209
Brugia malayi beta-lactamase family protein 0.0036 0.0023 0.0023
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.006 0.0052 0.0052
Echinococcus multilocularis nAChR subunit 0.0037 0.0024 0.0179
Trypanosoma cruzi histone deacetylase, putative 0.003 0.0017 0.0015
Onchocerca volvulus Ribonuclease H1 homolog 0.0025 0.0011 0.1012
Echinococcus granulosus caspase 2 0.0087 0.0086 0.0631
Loa Loa (eye worm) beta-lactamase 0.0036 0.0023 0.0023
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0038 0.0025 0.0187
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0922 0.1102 0.8073
Echinococcus multilocularis dnaJ subfamily B 0.0466 0.0547 0.4006
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Schistosoma mansoni caspase-3 (C14 family) 0.0118 0.0123 0.0903
Loa Loa (eye worm) acetylcholine receptor protein 0.0023 0.0008 0.0008
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0031 0.0231
Schistosoma mansoni alpha-1 adrenergic receptor 0.0038 0.0025 0.0187
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0339 0.0393 0.2878
Echinococcus multilocularis neuropeptide Y receptor 0.0038 0.0025 0.0187
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0013 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0034 0.4538
Echinococcus granulosus voltage gated potassium channel 0.0024 0.0009 0.0069
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0022 0.0006 0.1411
Echinococcus granulosus 7tm_1 domain containing protein 0.0038 0.0025 0.0187
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0029 1
Brugia malayi hypothetical protein 0.0027 0.0013 0.0013
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0023 0.0023
Trypanosoma cruzi metacaspase, putative 0.0045 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0176 0.0194 0.1424
Onchocerca volvulus 0.0038 0.0025 0.2778
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Echinococcus multilocularis alkaline phosphatase 0.0339 0.0393 0.2878
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0013 0.3262
Chlamydia trachomatis UDP-3-O-acylglucosamine N-acyltransferase 0.0022 0.0006 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0002 0.0016
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0002 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0002 0.0002
Schistosoma mansoni nAChR subunit 0.006 0.0052 0.0383
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0006 0.1168
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0084 0.0082 0.0082
Brugia malayi G protein-coupled receptor F59B2.13 0.0038 0.0025 0.0025
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0038 0.0025 0.0187
Brugia malayi Cation transporter family protein 0.006 0.0052 0.0052
Schistosoma mansoni phosphoglucomutase 0.0025 0.0011 0.0078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0025 0.0187
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0038 0.0025 0.2778
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0002 0.0002
Echinococcus multilocularis p2X purinoceptor 4 0.1137 0.1366 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0038 0.0025 0.0025
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.006 0.0052 0.0383
Brugia malayi steroid hormone receptor 0.0018 0.0002 0.0002
Leishmania major carbonic anhydrase-like protein 0.0922 0.1102 0.1101
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0024
Brugia malayi hypothetical protein 0.0038 0.0025 0.0025
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0038 0.0025 0.0187
Schistosoma mansoni P2X receptor subunit 0.0526 0.0621 0.4545
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0002 0.0011
Schistosoma mansoni hypothetical protein 0.0342 0.0396 0.29
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0022 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) dynactin 5 0.0022 0.0006 0.0006
Brugia malayi hypothetical protein 0.0022 0.0006 0.0006
Brugia malayi hypothetical protein 0.0022 0.0006 0.0006
Schistosoma mansoni amine GPCR 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Mycobacterium tuberculosis Conserved hypothetical protein 0.0835 0.0997 0.18
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0038 0.0025 0.0187
Schistosoma mansoni hypothetical protein 0.0018 0.0002 0.0011
Brugia malayi Histone deacetylase family protein 0.003 0.0017 0.0017
Schistosoma mansoni acetylcholine receptor-related 0.0023 0.0008 0.0055
Schistosoma mansoni amine GPCR 0.0038 0.0025 0.0187
Echinococcus granulosus carbonic anhydrase 0.0342 0.0396 0.29
Leishmania major C-8 sterol isomerase-like protein 0.8224 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0034 0.4538
Loa Loa (eye worm) neuropeptide F receptor 0.0038 0.0025 0.0025
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.006 0.0052 0.0383
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0002
Echinococcus granulosus histone deacetylase 0.003 0.0017 0.0122
Echinococcus granulosus tm gpcr rhodopsin 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0023 0.3029
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0023 0.0168
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0013 0.0267
Echinococcus granulosus g protein coupled receptor 0.0038 0.0025 0.0187
Schistosoma mansoni hypothetical protein 0.0043 0.0031 0.0231
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0002 0.0002
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0118 0.0123 0.0903
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0002 0.0016
Echinococcus multilocularis glycine receptor subunit alpha 1 0.006 0.0052 0.0383
Echinococcus multilocularis histone deacetylase 0.003 0.0017 0.0122
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.006 0.0052 0.0383
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0023 0.0008 0.0055
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0023 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0002 0.0016
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.006 0.0052 0.0383
Trypanosoma brucei metacaspase MCA2 0.0045 0.0034 0.0032
Onchocerca volvulus 0.0038 0.0025 0.2778
Trypanosoma cruzi metacaspase, putative 0.0045 0.0034 0.0032
Brugia malayi AKH receptor 0.0038 0.0025 0.0025
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0022 0.0006 0.0776
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.006 0.0052 0.0383
Trichomonas vaginalis glucose-1-phosphate thymidylyltransferase, putative 0.0022 0.0006 0.0776
Mycobacterium tuberculosis Conserved protein 0.0036 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0023 0.0008 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0023 0.3029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0002
Echinococcus granulosus GPCR family 2 0.0018 0.0002 0.0011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0002 0.0016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0038 0.0025 0.0187
Echinococcus multilocularis neuropeptide receptor 0.0038 0.0025 0.0187
Onchocerca volvulus 0.0038 0.0025 0.2778
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0037 0.0024 0.0179
Entamoeba histolytica translation initiation factor eIF-2B epsilon subunit, putative 0.0022 0.0006 0.1411
Schistosoma mansoni hypothetical protein 0.0038 0.0025 0.0187
Echinococcus granulosus carbonic anhydrase 0.0342 0.0396 0.29
Schistosoma mansoni dynactin subunit P25 0.0022 0.0006 0.0043
Echinococcus multilocularis caspase 8 0.0045 0.0034 0.0252
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.006 0.0052 0.0383
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.006 0.0052 0.0383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Brugia malayi nuclear receptor NHR-88 0.0018 0.0002 0.0002
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.0034 0.0032
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0084 0.0082 0.0604
Onchocerca volvulus 0.006 0.0052 0.5972
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.006 0.0052 0.0052
Brugia malayi G-protein coupled receptor 0.0038 0.0025 0.0025
Onchocerca volvulus 0.0038 0.0025 0.2778
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0023 0.0168
Schistosoma mansoni tyrosine kinase 0.1126 0.1351 0.9896
Entamoeba histolytica maltose O-acetyltransferase, putative 0.0022 0.0006 0.1411
Schistosoma mansoni biogenic amine receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0295 0.0339 0.0339
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0025 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0023
Brugia malayi RNase H family protein 0.0025 0.0011 0.0011
Trichomonas vaginalis mannose-1-phosphate guanyltransferase, putative 0.0022 0.0006 0.0776
Schistosoma mansoni hypothetical protein 0.0018 0.0002 0.0011
Entamoeba histolytica acetyltransferase, putative 0.0022 0.0006 0.1411
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.4204 0.5101 0.5101
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.006 0.0052 0.0052
Toxoplasma gondii eukaryotic initiation factor 2B epsilon subunit, putative 0.0022 0.0006 0.0038
Trypanosoma brucei carbonic anhydrase-like protein 0.0922 0.1102 0.1101
Echinococcus granulosus neuropeptide Y receptor 0.0038 0.0025 0.0187
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0038 0.0025 0.0187
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0034 0.4538
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0034 0.4538
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0002 0.0016
Brugia malayi Melatonin receptor type 1A 0.0038 0.0025 0.0025
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0038 0.0025 0.0025
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.4555 0.5529 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0025 0.0187
Echinococcus granulosus nAChR subunit 0.006 0.0052 0.0383
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0025 0.0187
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0025 0.0187
Schistosoma mansoni P2X receptor subunit 0.1137 0.1366 1
Echinococcus multilocularis G protein coupled receptor 139 0.0038 0.0025 0.0187
Mycobacterium tuberculosis Conserved hypothetical protein 0.0835 0.0997 0.18
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0002 0.0002
Schistosoma mansoni neuropeptide receptor 0.0038 0.0025 0.0187
Schistosoma mansoni tyrosine kinase 0.0599 0.0709 0.5191
Trypanosoma brucei ribonuclease H1 0.0025 0.0011 0.0009
Echinococcus multilocularis fmrfamide receptor 0.0038 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0025
Schistosoma mansoni nAChR subunit 0.006 0.0052 0.0383
Trypanosoma cruzi metacaspase, putative 0.0045 0.0034 0.0032
Brugia malayi hypothetical protein 0.0038 0.0025 0.0025

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 100 mg kg-1 In vivo analgesic activity in hot plate test after subcutaneous administration in mice ChEMBL. No reference
ED50 (functional) > 100 mg kg-1 In vivo analgesic activity in hot plate test after subcutaneous administration in mice ChEMBL. No reference
Ki (binding) nM Inhibition of [3H]-[D-Pen2, D-Pen5]-enkephalin (2 nM) to Opioid receptor delta 1 of male Sprague-Dawley rat brain homogenate; Not detectable ChEMBL. No reference
Ki (binding) 0 nM Inhibition of [3H]-[D-Pen2, D-Pen5]-enkephalin (2 nM) to Opioid receptor delta 1 of male Sprague-Dawley rat brain homogenate; Not detectable ChEMBL. No reference
Ki (binding) = 198 nM Inhibition of 9 (2nM) binding to Opioid receptor kappa 1 of rat brain homogenate ChEMBL. No reference
Ki (binding) = 198 nM Inhibition of 9 (2nM) binding to Opioid receptor kappa 1 of rat brain homogenate ChEMBL. No reference
Ki (binding) > 5000 nM Inhibition of [3H]-dihydromorphine (1 nM) binding to mu opioid receptor of rat brain homogenate ChEMBL. No reference
Ki (binding) > 5000 nM Inhibition of [3H]-dihydromorphine (1 nM) binding to mu opioid receptor of rat brain homogenate ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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