Detailed information for compound 286422

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 336.858 | Formula: C21H21ClN2
  • H donors: 0 H acceptors: 0 LogP: 4.72 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)C1=Cc2cc(Cl)ccc2C(=C)c2c1cccc2
  • InChi: 1S/C21H21ClN2/c1-15-18-8-7-17(22)13-16(18)14-21(20-6-4-3-5-19(15)20)24-11-9-23(2)10-12-24/h3-8,13-14H,1,9-12H2,2H3
  • InChiKey: PRRVUGWDILXJOU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine D1 receptor Starlite/ChEMBL References
Rattus norvegicus Muscarinic acetylcholine receptor Starlite/ChEMBL References
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_132667 All targets in OG5_132667
Schistosoma japonicum 5-hydroxytryptamine receptor 1, putative Get druggable targets OG5_132667 All targets in OG5_132667
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Dopamine D2 receptor   444 aa 476 aa 24.2 %
Echinococcus granulosus alpha 1A adrenergic receptor Muscarinic acetylcholine receptor   466 aa 459 aa 20.0 %
Echinococcus granulosus g protein coupled receptor Dopamine D2 receptor   444 aa 457 aa 21.0 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Dopamine D1 receptor   446 aa 407 aa 33.7 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D1 receptor   446 aa 366 aa 35.2 %
Echinococcus multilocularis g protein coupled receptor Dopamine D2 receptor   444 aa 465 aa 21.5 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D1 receptor   446 aa 373 aa 25.5 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Muscarinic acetylcholine receptor   466 aa 461 aa 23.9 %
Onchocerca volvulus Muscarinic acetylcholine receptor   466 aa 472 aa 24.6 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) Muscarinic acetylcholine receptor   466 aa 461 aa 26.0 %
Onchocerca volvulus Dopamine D2 receptor   444 aa 418 aa 23.0 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Loa Loa (eye worm) TYRA-2 protein Muscarinic acetylcholine receptor   466 aa 497 aa 24.7 %
Schistosoma mansoni biogenic amine (5HT) receptor Dopamine D1 receptor   446 aa 394 aa 29.9 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Dopamine D2 receptor   444 aa 386 aa 19.7 %
Schistosoma mansoni growth hormone secretagogue receptor Muscarinic acetylcholine receptor   466 aa 462 aa 19.9 %
Onchocerca volvulus Dopamine D1 receptor   446 aa 357 aa 21.0 %
Loa Loa (eye worm) hypothetical protein Dopamine D1 receptor   446 aa 370 aa 24.9 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Echinococcus multilocularis alpha 1A adrenergic receptor Muscarinic acetylcholine receptor   466 aa 459 aa 21.1 %
Schistosoma japonicum Octopamine receptor 1, putative Muscarinic acetylcholine receptor   466 aa 412 aa 22.6 %
Schistosoma mansoni amine GPCR Dopamine D2 receptor   444 aa 424 aa 32.1 %
Schistosoma mansoni biogenic amine receptor Muscarinic acetylcholine receptor   466 aa 484 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0599 0.1235
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0016 0.0069 0.0109
Schistosoma mansoni smad1 5 8 and 0.0018 0.0104 0.0165
Schistosoma mansoni hypothetical protein 0.0023 0.0196 0.031
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0083 0.017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0141
Plasmodium vivax glutathione reductase, putative 0.0048 0.0633 0.1845
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0196 0.0291
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0196 0.031
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0027 0.0042
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0027 0.0042
Echinococcus granulosus smad 0.0018 0.0104 0.0165
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0057 0.0057
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0133 0.0211
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0196 0.031
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0057 0.0057
Schistosoma mansoni SET domain protein 0.0072 0.1053 0.1667
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0039 0.0482 0.1384
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Brugia malayi RasGEF domain containing protein 0.0014 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0444 0.0702
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0015 0.0057 0.009
Onchocerca volvulus 0.0023 0.0196 0.0291
Brugia malayi hypothetical protein 0.0078 0.1176 0.1176
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus granulosus importin subunit beta 1 0.0034 0.0388 0.0614
Brugia malayi Serotonin receptor 0.0023 0.0196 0.0196
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.3436 0.7359
Echinococcus granulosus fmrfamide receptor 0.0023 0.0196 0.031
Brugia malayi hypothetical protein 0.0019 0.0133 0.0133
Brugia malayi G-protein coupled receptor 0.0023 0.0196 0.0196
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0021 0.0157 0.036
Schistosoma mansoni neuropeptide receptor 0.0023 0.0196 0.031
Brugia malayi Dopamine receptor 0.0023 0.0196 0.0196
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0196 0.0291
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.00000000046651
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0196 0.031
Brugia malayi RE15519p 0.0023 0.0196 0.0196
Leishmania major DNA polymerase kappa, putative 0.0109 0.1713 0.4862
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0141
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus multilocularis nAChR subunit 0.0015 0.0057 0.009
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0118 0.0109
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0124 0.0197
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0255 0.0513
Brugia malayi hypothetical protein 0.0023 0.0196 0.0196
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0057 0.009
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0196 0.031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.0184
Echinococcus granulosus serotonin receptor 0.0023 0.0196 0.031
Brugia malayi hypothetical protein 0.0021 0.0157 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0157 0.036
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0124 0.0297
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0014 0.0035 0.0023
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0027 0.0042
Schistosoma mansoni DNA helicase recq1 0.0019 0.0124 0.0197
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0091 0.1392 0.3905
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.00000000046651
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0201 0.0351
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus granulosus glycine receptor subunit beta 0.0015 0.0057 0.009
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0083 0.0141
Schistosoma mansoni nAChR subunit 0.0015 0.0057 0.009
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.006 0.0841 0.1332
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0196 0.031
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0196 0.031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Brugia malayi DIX domain containing protein 0.0019 0.0133 0.0133
Echinococcus granulosus son of sevenless 1 0.0014 0.0035 0.0055
Schistosoma mansoni kinase 0.0105 0.1648 0.2609
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1102 0.1744
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0444 0.0444
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0394 0.6742 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0057 0.009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0606 0.0959
Loa Loa (eye worm) RecQ helicase 0.0046 0.0599 0.0888
Schistosoma mansoni hypothetical protein 0.0361 0.6161 0.9755
Schistosoma mansoni smad 0.0018 0.0104 0.0165
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0196 0.031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.00000000046651
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Brugia malayi hypothetical protein 0.0023 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0037 0.0444 0.0702
Trichomonas vaginalis chromobox protein, putative 0.0049 0.066 0.1367
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0761 0.2236
Plasmodium falciparum importin beta, putative 0.0034 0.0388 0.1098
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0196 0.031
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0196 0.031
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0027 0.0000000006578
Entamoeba histolytica peptidase, C54 family 0.006 0.0841 0.2389
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0196 0.031
Treponema pallidum phosphoglycerate kinase 0.02 0.3313 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.1159 0.3209
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0196 0.031
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0196 0.031
Loa Loa (eye worm) hypothetical protein 0.02 0.3313 0.4913
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0015 0.0057 0.009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1102 0.1744
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0196 0.031
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0196 0.031
Onchocerca volvulus 0.0023 0.0196 0.0291
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0014 0.0035 0.0023
Schistosoma mansoni hypothetical protein 0.0078 0.1176 0.1862
Trypanosoma brucei phosphoglycerate kinase, putative 0.0073 0.1084 0.2985
Echinococcus granulosus chromobox protein 1 0.0082 0.1233 0.1952
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0109 0.1713 0.5048
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.004
Leishmania major phosphoglycerate kinase C, glycosomal 0.02 0.3313 0.9632
Brugia malayi follicle stimulating hormone receptor 0.0023 0.0196 0.0196
Brugia malayi MH2 domain containing protein 0.026 0.4388 0.4388
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0057 0.009
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1926 0.5708
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0133 0.0211
Echinococcus multilocularis snurportin 1 0.0361 0.6161 0.9755
Trypanosoma cruzi DNA polymerase eta, putative 0.0087 0.1326 0.3796
Onchocerca volvulus 0.0023 0.0196 0.0291
Brugia malayi hypothetical protein 0.0023 0.0196 0.0196
Brugia malayi Melatonin receptor type 1A 0.0023 0.0196 0.0196
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0124 0.0197
Brugia malayi N-terminal motif family protein 0.0394 0.6742 0.6742
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1926 0.5708
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0196 0.031
Echinococcus granulosus phosphoglycerate kinase 1 0.02 0.3313 0.5245
Loa Loa (eye worm) DIX domain-containing protein 0.0019 0.0133 0.0197
Echinococcus granulosus bloom syndrome protein 0.0046 0.0599 0.0948
Brugia malayi Protein cec-1. 0.0013 0.0027 0.0027
Echinococcus multilocularis serotonin receptor 0.0023 0.0196 0.031
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.00000000046651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0196 0.031
Schistosoma mansoni hypothetical protein 0.0021 0.0157 0.0249
Onchocerca volvulus 0.0021 0.0157 0.0233
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0057 0.0057
Brugia malayi PWWP domain containing protein 0.0021 0.0157 0.0157
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1712 0.5045
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0083 0.0131
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0606 0.0959
Brugia malayi RasGEF domain containing protein 0.0014 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0606 0.0959
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0196 0.031
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0014 0.0035 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.2127 0.6095
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0015 0.0057 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.1713 0.4862
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0201 0.0487
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0118 0.0105
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0345 0.0912
Schistosoma mansoni opsin-like receptor 0.0023 0.0196 0.031
Schistosoma mansoni hypothetical protein 0.0021 0.0157 0.0249
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0027 0.0000000006578
Schistosoma mansoni hypothetical protein 0.037 0.6315 1
Onchocerca volvulus 0.0015 0.0057 0.0084
Trypanosoma cruzi DNA polymerase kappa, putative 0.0132 0.2127 0.615
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.00000000046651
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.00000000046651
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0083 0.017
Echinococcus multilocularis serotonin receptor 0.0023 0.0196 0.031
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.1102 0.1102
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0133 0.0211
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0083 0.0121
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0444 0.0444
Onchocerca volvulus 0.0023 0.0196 0.0291
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0196 0.0196
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0196 0.031
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0841 0.1758
Trichomonas vaginalis phosphoglycerate kinase, putative 0.02 0.3313 0.7092
Leishmania major hypothetical protein, conserved 0.0021 0.0157 0.0222
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0027 0.0042
Brugia malayi MH2 domain containing protein 0.0018 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0014 0.0035 0.0023
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0196 0.031
Echinococcus multilocularis tar DNA binding protein 0.0074 0.1102 0.1744
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0057 0.009
Schistosoma mansoni autophagin-1 (C54 family) 0.006 0.0841 0.1332
Brugia malayi ImpB/MucB/SamB family protein 0.0101 0.1577 0.1577
Loa Loa (eye worm) Smad1 0.0018 0.0104 0.0154
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.00000000046651
Onchocerca volvulus 0.0023 0.0196 0.0291
Echinococcus granulosus Pleckstrin G protein interacting region 0.0019 0.0133 0.0211
Schistosoma mansoni flap endonuclease-1 0.0024 0.021 0.0333
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0345 0.0969
Schistosoma mansoni amine GPCR 0.0023 0.0196 0.031
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0083 0.0131
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0015 0.0057 0.0084
Entamoeba histolytica peptidase, C54 family 0.0023 0.0201 0.0509
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0196 0.031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0196 0.031
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0255 0.0694
Giardia lamblia Kinase, PLK 0.0207 0.3436 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0196 0.031
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0057 0.0057
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0196 0.031
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0015 0.0057 0.009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Trypanosoma brucei DNA polymerase eta, putative 0.0157 0.2557 0.7379
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.004
Schistosoma mansoni hypothetical protein 0.0025 0.0226 0.0358
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0196 0.031
Echinococcus multilocularis hepatoma derived growth factor protein 0.0021 0.0157 0.0249
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0133 0.0197
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Trypanosoma brucei DNA damage repair protein, putative 0.0031 0.0345 0.0782
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Toxoplasma gondii thioredoxin reductase 0.0048 0.0633 0.1845
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0052
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0118 0.0187
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0196 0.031
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0196 0.031
Brugia malayi Heterochromatin protein 1 0.0082 0.1233 0.1233
Echinococcus granulosus nAChR subunit 0.0015 0.0057 0.009
Schistosoma mansoni smad1 5 8 and 0.0018 0.0104 0.0165
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0196 0.031
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.3436 0.7359
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1102 0.1744
Plasmodium vivax importin-beta 2, putative 0.0034 0.0388 0.1098
Brugia malayi hypothetical protein 0.0153 0.2482 0.2482
Trypanosoma brucei DNA polymerase IV, putative 0.0132 0.2127 0.6095
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.00000000063396
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.004
Brugia malayi hypothetical protein 0.0023 0.0196 0.0196
Loa Loa (eye worm) glutaminase 0.0276 0.466 0.6912
Onchocerca volvulus 0.0023 0.0196 0.0291
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0015 0.0057 0.009
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0196 0.031
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0021 0.0157 0.036
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0196 0.031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.004
Onchocerca volvulus 0.0023 0.0196 0.0291
Leishmania major importin beta-1 subunit, putative 0.0027 0.0275 0.0572
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0091 0.1392 0.3905
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0015 0.0057 0.0057
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0015 0.0057 0.0084
Brugia malayi ORL1-like opioid receptor 0.0023 0.0196 0.0196
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0133 0.0133
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0057 0.009
Onchocerca volvulus 0.0023 0.0196 0.0291
Brugia malayi hypothetical protein 0.0013 0.0027 0.0027
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0226 0.0358
Loa Loa (eye worm) ACC-1 protein 0.0015 0.0057 0.0084
Loa Loa (eye worm) hypothetical protein 0.009 0.1372 0.2035
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0133 0.0211
Schistosoma mansoni phd finger protein 0.0021 0.0157 0.0249
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0196 0.031
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0014 0.0035 0.0023
Schistosoma mansoni nAChR subunit 0.0015 0.0057 0.009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0196 0.031
Trypanosoma brucei polo-like protein kinase 0.0207 0.3436 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0233
Brugia malayi polk-prov protein 0.0063 0.0895 0.0895
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0118 0.0105
Trichomonas vaginalis ras GTP exchange factor, putative 0.0014 0.0035 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0196 0.031
Brugia malayi GnHR receptor homolog 0.0023 0.0196 0.0196
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0014 0.0035 0.0023
Onchocerca volvulus 0.0013 0.0027 0.004
Brugia malayi G protein-coupled receptor 0.0023 0.0196 0.0196
Brugia malayi Dopamine receptor protein 2 0.0023 0.0196 0.0196
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.00000000063396
Leishmania major hypothetical protein, conserved 0.0055 0.0761 0.2024
Plasmodium falciparum DNA repair protein REV1, putative 0.0031 0.0345 0.0969
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0196 0.031
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0196 0.031
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0027 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.2127 0.6095
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0606 0.0959
Trypanosoma cruzi DNA polymerase eta, putative 0.0157 0.2557 0.7416
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0141
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0226 0.0358
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0118 0.0187
Onchocerca volvulus 0.0023 0.0196 0.0291
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0005 0.0005
Schistosoma mansoni chromobox protein 0.0013 0.0027 0.0042
Loa Loa (eye worm) hypothetical protein 0.0046 0.0599 0.0888
Brugia malayi MH2 domain containing protein 0.0018 0.0104 0.0104
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0196 0.031
Brugia malayi hypothetical protein 0.0023 0.0196 0.0196
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0083 0.017
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0761 0.2236
Loa Loa (eye worm) hypothetical protein 0.0019 0.0133 0.0197
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0132 0.2127 0.4532
Toxoplasma gondii hypothetical protein 0.0019 0.0133 0.0323
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0196 0.031
Entamoeba histolytica serine/threonine protein kinase, putative 0.0207 0.3436 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0606 0.0606
Brugia malayi Thioredoxin reductase 0.0048 0.0633 0.0633
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0015 0.0057 0.009
Trichomonas vaginalis DNA polymerase eta, putative 0.0132 0.2127 0.4532
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.00000000046651
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0841 0.1758
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0027 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0606 0.0959
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.1176 0.1862
Brugia malayi ImpB/MucB/SamB family protein 0.0157 0.2557 0.2557
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0019 0.0133 0.0211
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.00000000046651
Onchocerca volvulus 0.0015 0.0057 0.0084
Echinococcus multilocularis Chromo domain 0.0013 0.0027 0.0042
Schistosoma mansoni DNA polymerase IV / kappa 0.0031 0.0345 0.0546
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0207 0.3436 0.5441
Trypanosoma brucei trypanothione reductase 0.0048 0.0633 0.1641
Entamoeba histolytica hypothetical protein 0.0027 0.0275 0.0727
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.02 0.3313 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.05 0.1441
Schistosoma mansoni importin beta-1 0.0034 0.0388 0.0614
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Schistosoma mansoni neuropeptide receptor 0.0023 0.0196 0.031
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0019 0.0133 0.0211
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1102 0.1744
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0118 0.0277
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0255 0.0513
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.2127 0.6095
Trichomonas vaginalis phosphoglycerate kinase, putative 0.02 0.3313 0.7092
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0015 0.0057 0.009
Echinococcus granulosus chromobox protein 1 0.0082 0.1233 0.1952
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.0196 0.031
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0444 0.0702
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0104 0.0165
Trypanosoma cruzi DNA polymerase kappa, putative 0.0132 0.2127 0.615
Brugia malayi Cation transporter family protein 0.0015 0.0057 0.0057
Echinococcus granulosus Peptidase C54 0.006 0.0841 0.1332
Trypanosoma cruzi phosphoglycerate kinase, putative 0.02 0.3313 0.9637
Brugia malayi glutaminase DH11.1 0.0276 0.466 0.466
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0761 0.2136
Loa Loa (eye worm) TAR-binding protein 0.0074 0.1102 0.1634
Schistosoma mansoni histamine h1 receptor 0.0023 0.0196 0.031
Trypanosoma cruzi DNA damage repair protein, putative 0.0031 0.0345 0.0912
Toxoplasma gondii phosphoglycerate kinase PGKI 0.02 0.3313 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0117 0.1854 0.275
Echinococcus multilocularis PWWP domain containing protein 2A 0.0021 0.0157 0.0249
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0196 0.031
Brugia malayi hypothetical protein 0.0036 0.0417 0.0417
Trypanosoma cruzi DNA polymerase kappa, putative 0.0132 0.2127 0.615
Echinococcus multilocularis son of sevenless 1 0.0014 0.0035 0.0055
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0222 0.0422
Leishmania major DNA polymerase eta, putative 0.0087 0.1326 0.3707
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0196 0.031
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0057 0.009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0124 0.0297
Brugia malayi hypothetical protein 0.0055 0.0761 0.0761
Trypanosoma cruzi DNA damage repair protein, putative 0.0031 0.0345 0.0912
Leishmania major DNA polymerase eta, putative 0.0157 0.2557 0.7379
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0083 0.017
Loa Loa (eye worm) glutaminase 2 0.0276 0.466 0.6912
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0196 0.031
Schistosoma mansoni chromobox protein 0.0013 0.0027 0.0042
Echinococcus granulosus hepatoma derived growth factor protein 0.0021 0.0157 0.0249
Loa Loa (eye worm) hypothetical protein 0.0034 0.0388 0.0575
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0013 0.0023 0.0036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0196 0.031
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0196 0.031
Plasmodium falciparum thioredoxin reductase 0.0048 0.0633 0.1845
Onchocerca volvulus 0.0023 0.0196 0.0291
Schistosoma mansoni terminal deoxycytidyl transferase 0.0101 0.1577 0.2496
Plasmodium falciparum cysteine protease ATG4, putative 0.0023 0.0201 0.0529
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.3436 0.7359
Onchocerca volvulus 0.0014 0.0035 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.3436 0.5441
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0196 0.031
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0841 0.1758
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0196 0.031
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0196 0.031
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0083 0.0131
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.004
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0124 0.0124
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0841 0.1758
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0015 0.0057 0.0084
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0761 0.2136
Echinococcus granulosus g protein coupled receptor 0.0023 0.0196 0.031
Echinococcus granulosus PWWP domain containing protein 2A 0.0021 0.0157 0.0249
Entamoeba histolytica protein kinase, putative 0.0091 0.1392 0.4005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0196 0.031
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0196 0.031
Schistosoma mansoni nAChR subunit 0.0015 0.0057 0.009
Toxoplasma gondii phosphoglycerate kinase PGKII 0.02 0.3313 1
Schistosoma mansoni hypothetical protein 0.0037 0.0444 0.0702
Brugia malayi Cation transporter family protein 0.0015 0.0057 0.0057
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0196 0.031
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0196 0.031
Entamoeba histolytica hypothetical protein 0.0013 0.0027 0.00000000063396
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0118 0.0277
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Schistosoma mansoni chromobox protein 0.0082 0.1233 0.1952
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0073 0.1084 0.3084
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0255 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0363 0.0726
Plasmodium falciparum glutathione reductase 0.0048 0.0633 0.1845
Schistosoma mansoni dep domain containing protein 0.0019 0.0133 0.0211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0196 0.031
Echinococcus granulosus somatostatin receptor 0.0023 0.0196 0.031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.00000000046651
Brugia malayi Phosphoglycerate kinase 0.0073 0.1084 0.1084
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0027 0.0000000006578
Loa Loa (eye worm) hypothetical protein 0.0139 0.2246 0.3332
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0633 0.1002
Trypanosoma cruzi polo-like protein kinase, putative 0.0207 0.3436 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0015 0.0057 0.009
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.0429 0.0679
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0633 0.1002
Echinococcus multilocularis phosphoglycerate kinase 1 0.02 0.3313 0.5245
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0072 0.1053 0.1667
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0201 0.0487
Loa Loa (eye worm) hypothetical protein 0.008 0.1201 0.1782
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0133 0.0133
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.0196 0.031
Trypanosoma brucei chrX additional, unordered contigs 0.0031 0.0345 0.0782
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0196 0.031
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0207 0.3436 0.5441
Schistosoma mansoni nAChR subunit 0.0015 0.0057 0.009
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0104 0.0165
Entamoeba histolytica protein kinase, putative 0.0091 0.1392 0.4005
Entamoeba histolytica hypothetical protein 0.0078 0.1176 0.3371
Brugia malayi hypothetical protein 0.0023 0.0196 0.0196
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0196 0.031
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0196 0.031
Entamoeba histolytica peptidase, C54 family 0.0023 0.0201 0.0509
Brugia malayi MH1 domain containing protein 0.0018 0.0104 0.0104
Entamoeba histolytica peptidase, C54 family 0.0023 0.0201 0.0509
Brugia malayi hypothetical protein 0.0023 0.0196 0.0196
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0118 0.0175
Schistosoma mansoni hypothetical protein 0.0023 0.0196 0.031
Chlamydia trachomatis phosphoglycerate kinase 0.02 0.3313 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0118 0.0187
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Brugia malayi Peptidase family C54 containing protein 0.006 0.0841 0.0841
Echinococcus granulosus traf and tnf receptor associated protein 0.0179 0.2954 0.4678
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0275 0.0705
Brugia malayi glutathione reductase 0.0048 0.0633 0.0633
Echinococcus granulosus orexin receptor type 2 0.0023 0.0196 0.031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.004
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0014 0.0035 0.0055
Mycobacterium ulcerans DNA polymerase IV 0.0132 0.2127 0.4466
Entamoeba histolytica hypothetical protein 0.0078 0.1176 0.3371
Onchocerca volvulus 0.0023 0.0196 0.0291
Loa Loa (eye worm) transcription factor SMAD2 0.026 0.4388 0.6508
Echinococcus multilocularis Smad4 0.0018 0.0104 0.0165
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.00000000046651
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0014 0.0035 0.0055
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0196 0.0291
Brugia malayi sulfakinin receptor protein 0.0023 0.0196 0.0196
Schistosoma mansoni biogenic amine receptor 0.0023 0.0196 0.031
Plasmodium falciparum flap endonuclease 1 0.0026 0.0255 0.0694
Onchocerca volvulus 0.0023 0.0196 0.0291
Schistosoma mansoni hypothetical protein 0.0013 0.0027 0.0042
Schistosoma mansoni opsin-like receptor 0.0023 0.0196 0.031
Schistosoma mansoni glutaminase 0.0276 0.466 0.7379
Entamoeba histolytica deoxycytidyl transferase, putative 0.0101 0.1577 0.4545
Schistosoma mansoni Smad4 0.0018 0.0104 0.0165
Brugia malayi neuropeptide F receptor 0.0023 0.0196 0.0196
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0073 0.1084 0.3084
Echinococcus multilocularis Peptidase C54 0.006 0.0841 0.1332
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.006 0.0841 0.1758
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0027 0.0027
Onchocerca volvulus 0.0023 0.0196 0.0291
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0196 0.031
Mycobacterium tuberculosis Probable reductase 0.0109 0.1712 0.5045
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0118 0.0244
Schistosoma mansoni DNA polymerase eta 0.0157 0.2557 0.4049
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0174 0.2862 0.8628
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0027 0.0042
Echinococcus granulosus hypothetical protein 0.0023 0.0196 0.031
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0014 0.0035 0.0023
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0023 0.02 0.0316
Loa Loa (eye worm) hypothetical protein 0.0394 0.6742 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0015 0.0057 0.0057
Onchocerca volvulus Putative nachr subunit 0.0015 0.0057 0.0084
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0196 0.031
Brugia malayi RasGEF domain containing protein 0.0014 0.0035 0.0035
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.006 0.0841 0.2262
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.3436 0.7359
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0037 0.0444 0.0702
Echinococcus granulosus peregrin 0.0021 0.0157 0.0249
Schistosoma mansoni amine GPCR 0.0023 0.0196 0.031
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.0196 0.0291
Trichomonas vaginalis DNA helicase recq1, putative 0.0046 0.0599 0.1234
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0073 0.1084 0.3084
Echinococcus multilocularis ras GTP exchange factor 0.0014 0.0035 0.0055
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0196 0.0291
Echinococcus granulosus Smad4 0.0018 0.0104 0.0165
Loa Loa (eye worm) ACC-1 protein 0.0015 0.0057 0.0084
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Trichomonas vaginalis ras GTP exchange factor, putative 0.0014 0.0035 0.0017
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0073 0.1084 0.3084
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0073 0.1084 0.2985
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0015 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.008 0.1201 0.1902
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0196 0.031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.004
Loa Loa (eye worm) RNA binding protein 0.0074 0.1102 0.1634
Toxoplasma gondii hypothetical protein 0.0021 0.0157 0.0397
Loa Loa (eye worm) hypothetical protein 0.006 0.0841 0.1248
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0083 0.0083
Plasmodium vivax phosphoglycerate kinase, putative 0.02 0.3313 1
Echinococcus granulosus dual specificity 0.0091 0.1392 0.2205
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0196 0.0196
Trypanosoma brucei phosphoglycerate kinase 0.02 0.3313 0.9632
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0255 0.0492
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0104 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.1392 0.2205
Schistosoma mansoni smad1 5 8 and 0.0018 0.0104 0.0165
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0118 0.0277
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0015 0.0057 0.0057
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0104 0.0165
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0761 0.2236
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0101 0.1577 0.2496
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0196 0.031
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0015 0.0057 0.0057
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0196 0.031
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0444 0.0702
Echinococcus granulosus flap endonuclease 1 0.0026 0.0255 0.0403
Echinococcus granulosus Chromo domain 0.0013 0.0027 0.0042
Onchocerca volvulus 0.0036 0.0424 0.063
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0761 0.2024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.1176 0.1862
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.0196 0.031
Schistosoma mansoni hepatoma derived growth factor 0.0021 0.0157 0.0249
Echinococcus multilocularis peregrin 0.0021 0.0157 0.0249
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0083 0.0141
Brugia malayi isocitrate dehydrogenase 0.0019 0.0118 0.0118
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0023 0.02 0.0316
Onchocerca volvulus 0.0015 0.0057 0.0084
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0196 0.031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0141
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0196 0.0291
Echinococcus granulosus sex peptide receptor 0.0023 0.0196 0.031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0141
Schistosoma mansoni hypothetical protein 0.0037 0.0444 0.0702
Mycobacterium ulcerans hypothetical protein 0.0031 0.0345 0.0573
Trypanosoma cruzi polo-like protein kinase, putative 0.0207 0.3436 1
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.02 0.3313 1
Echinococcus multilocularis chromobox protein 1 0.0082 0.1233 0.1952
Echinococcus granulosus neuropeptide receptor 0.0023 0.0196 0.031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.1577 0.4625
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0101 0.1577 0.2496
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0196 0.031
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.0196 0.0291
Echinococcus granulosus chromobox protein 2 0.0013 0.0027 0.0042
Trichomonas vaginalis chromobox protein, putative 0.0082 0.1233 0.2602
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.0599 0.1234
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0027 0.00000000046651
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0133 0.0211
Brugia malayi latrophilin 2 splice variant baaae 0.008 0.1201 0.1201
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0207 0.3436 1
Echinococcus granulosus snurportin 1 0.0361 0.6161 0.9755
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.1159 0.3209
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0196 0.031
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0196 0.031
Schistosoma mansoni dishevelled 0.0019 0.0133 0.0211
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0196 0.031
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0196 0.031
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0083 0.017
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0133 0.0197
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.00000000063396
Entamoeba histolytica hypothetical protein 0.0021 0.0157 0.0383
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0196 0.031
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0015 0.0057 0.009
Onchocerca volvulus 0.0023 0.0196 0.0291
Echinococcus granulosus g protein coupled receptor 0.0023 0.0196 0.031
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0124 0.0297
Giardia lamblia Phosphoglycerate kinase 0.02 0.3313 0.9632
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0196 0.031
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0091 0.1392 0.3991
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0014 0.0035 0.0023
Loa Loa (eye worm) helicase 0.0013 0.0027 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0196 0.031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0196 0.031
Brugia malayi hypothetical protein 0.0023 0.0196 0.0196
Entamoeba histolytica protein kinase domain containing protein 0.0091 0.1392 0.4005
Loa Loa (eye worm) RasGEF domain-containing protein 0.0014 0.0035 0.0052
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0015 0.0057 0.0084
Brugia malayi CHD4 protein 0.0013 0.0027 0.0027
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1712 0.5045
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0015 0.0057 0.009
Brugia malayi Importin beta-1 subunit 0.0034 0.0388 0.0388
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0057 0.009
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0083 0.0141
Brugia malayi Phosphoglycerate kinase 0.02 0.3313 0.3313
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0014 0.0035 0.0055
Echinococcus granulosus glycine receptor subunit beta 0.0015 0.0057 0.009
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0255 0.0403
Loa Loa (eye worm) hypothetical protein 0.0037 0.0444 0.0658
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0133 0.0211
Echinococcus granulosus tar DNA binding protein 0.0074 0.1102 0.1744
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0196 0.031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0196 0.031
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0196 0.0291
Brugia malayi MH1 domain containing protein 0.0018 0.0104 0.0104
Echinococcus multilocularis traf and tnf receptor associated protein 0.0179 0.2954 0.4678
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0057 0.009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0073 0.1084 0.3084
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0345 0.0782
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0196 0.0196
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.006 0.0841 0.1332
Onchocerca volvulus 0.0153 0.2482 0.3682
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0015 0.0057 0.009
Mycobacterium ulcerans phosphoglycerate kinase 0.02 0.3313 0.7057
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0633 0.1759
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0196 0.031
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0196 0.031
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.2127 0.6095
Trypanosoma brucei unspecified product 0.0125 0.199 0.5688
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.2127 0.6095
Brugia malayi putative neuropeptide receptor 0.0023 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Plasmodium falciparum phosphoglycerate kinase 0.02 0.3313 1
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.3436 0.7359
Loa Loa (eye worm) hypothetical protein 0.009 0.1372 0.2035
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0133 0.0211
Schistosoma mansoni biogenic amine receptor 0.0023 0.0196 0.031
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0255 0.0647
Onchocerca volvulus 0.0023 0.0196 0.0291
Echinococcus multilocularis somatostatin receptor 0.0023 0.0196 0.031
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0057 0.0057
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0196 0.031
Brugia malayi Flap endonuclease-1 0.0026 0.0255 0.0255
Loa Loa (eye worm) RasGEF domain-containing protein 0.0014 0.0035 0.0052
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0015 0.0057 0.009
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1926 0.1339
Onchocerca volvulus 0.0019 0.0133 0.0197
Brugia malayi SET domain containing protein 0.0016 0.0069 0.0069
Brugia malayi RNA, U transporter 1 0.0096 0.1488 0.1488
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0014 0.0035 0.0055
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0196 0.031
Schistosoma mansoni amine GPCR 0.0023 0.0196 0.031
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0015 0.0057 0.009
Echinococcus multilocularis Protein son of sevenless 0.0014 0.0035 0.0055
Trypanosoma brucei transcription elongation factor s-II, putative 0.0021 0.0157 0.0222
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0118 0.0105
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0196 0.031
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0118 0.0187
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0091 0.1392 0.2065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0015 0.0057 0.0084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0196 0.031
Echinococcus granulosus neuropeptide s receptor 0.0023 0.0196 0.031
Loa Loa (eye worm) MH2 domain-containing protein 0.026 0.4388 0.6508
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.2127 0.6095
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0895 0.2423
Onchocerca volvulus 0.0021 0.0157 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0363 0.0726
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0014 0.0035 0.0023
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0275 0.0535
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0118 0.0277
Loa Loa (eye worm) hypothetical protein 0.0063 0.0895 0.1328
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0196 0.031
Leishmania major DNA damage repair protein, putative 0.0031 0.0345 0.0782
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0196 0.0291
Brugia malayi Calcitonin receptor-like protein seb-1 0.0117 0.1854 0.1854
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Entamoeba histolytica phosphoglycerate kinase, putative 0.02 0.3313 0.9638
Schistosoma mansoni neuropeptide receptor 0.0023 0.0196 0.031
Loa Loa (eye worm) PWWP domain-containing protein 0.0021 0.0157 0.0233
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1712 0.5045
Brugia malayi chromobox protein homolog 3 0.0046 0.0599 0.0599
Brugia malayi G-protein coupled receptor 0.0023 0.0196 0.0196
Trichomonas vaginalis chromobox protein, putative 0.0082 0.1233 0.2602
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0109 0.1713 0.4862
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0222 0.0573
Loa Loa (eye worm) glutathione reductase 0.0048 0.0633 0.0939
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0388 0.0909
Schistosoma mansoni nAChR subunit 0.0015 0.0057 0.009
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0027 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0027 0.0027
Echinococcus multilocularis dna polymerase kappa 0.0132 0.2127 0.3368
Echinococcus granulosus GPCR family 2 0.0037 0.0444 0.0702
Loa Loa (eye worm) hypothetical protein 0.0157 0.2557 0.3793
Echinococcus multilocularis cysteine protease atg4b 0.006 0.0841 0.1332
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0027 0.0042
Trypanosoma brucei phosphoglycerate kinase 0.02 0.3313 0.9632
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0196 0.031
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0196 0.031
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0177 0.2907 0.4312
Plasmodium falciparum thioredoxin reductase 0.0017 0.0083 0.017
Onchocerca volvulus 0.0015 0.0057 0.0084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Brugia malayi serine/threonine-protein kinase plk-2 0.0207 0.3436 0.3436
Trichomonas vaginalis glutaminase, putative 0.0276 0.466 1
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.3436 0.7359
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0117 0.1854 0.1854
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1102 0.1744
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0101 0.1577 0.2496
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0083 0.017
Entamoeba histolytica hypothetical protein 0.0014 0.0035 0.0023
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0015 0.0057 0.0057
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0196 0.031
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0222 0.0416
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0196 0.031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Schistosoma mansoni neuropeptide receptor 0.0023 0.0196 0.031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Leishmania major trypanothione reductase 0.0048 0.0633 0.1641
Schistosoma mansoni dishevelled 0.0019 0.0133 0.0211
Brugia malayi hypothetical protein 0.0019 0.0133 0.0133
Brugia malayi TAR-binding protein 0.0074 0.1102 0.1102
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0057 0.0057
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0222 0.0416
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.2127 0.6095
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.2127 0.6095
Leishmania major phosphoglycerate kinase B, cytosolic 0.02 0.3313 0.9632
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0052
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0196 0.031
Brugia malayi N-terminal motif family protein 0.0014 0.0035 0.0035
Echinococcus granulosus neuropeptide receptor 0.0023 0.0196 0.031
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.1159 0.3209
Schistosoma mansoni amine GPCR 0.0023 0.0196 0.031
Schistosoma mansoni biogenic amine receptor 0.0023 0.0196 0.031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0222 0.0552
Onchocerca volvulus 0.0016 0.0069 0.0103
Echinococcus multilocularis smad 0.0018 0.0104 0.0165
Brugia malayi Cation transporter family protein 0.0015 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.037 0.6315 1
Brugia malayi RNA binding protein 0.0074 0.1102 0.1102
Schistosoma mansoni chromobox protein 0.0082 0.1233 0.1952
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0196 0.031
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0196 0.031
Schistosoma mansoni nAChR subunit 0.0015 0.0057 0.009
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1926 0.5708
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0196 0.031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0196 0.031
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0014 0.0035 0.0017
Brugia malayi Smad1 0.0018 0.0104 0.0104
Trypanosoma brucei unspecified product 0.007 0.1022 0.2802
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0057 0.009
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0015 0.0057 0.0084
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0015 0.0057 0.009
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0023 0.0201 0.0529
Schistosoma mansoni myosin xvIII 0.0023 0.0196 0.031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0083 0.0141
Loa Loa (eye worm) heterochromatin protein 1 0.0082 0.1233 0.1828
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0015 0.0057 0.0057
Onchocerca volvulus Serine\/threonine kinase homolog 0.0207 0.3436 0.5097
Schistosoma mansoni adenoreceptor 0.0023 0.0196 0.031
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.1102 0.1634
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0255 0.0378
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.3436 0.7359
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0633 0.1845
Leishmania major DNA polymerase kappa, putative 0.0031 0.0345 0.0782
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0118 0.0244
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0014 0.0035 0.0023
Schistosoma mansoni phosphoglycerate kinase 0.02 0.3313 0.5245
Echinococcus multilocularis GPCR, family 2 0.0037 0.0444 0.0702
Entamoeba histolytica hypothetical protein 0.0078 0.1176 0.3371
Schistosoma mansoni hypothetical protein 0.0023 0.0196 0.031
Entamoeba histolytica hypothetical protein 0.0091 0.1392 0.4005
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0133 0.0211
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0275 0.0535
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0196 0.0291
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0196 0.031
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0388 0.0614
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0027 0.0027
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0124 0.0197
Echinococcus granulosus geminin 0.037 0.6315 1
Onchocerca volvulus 0.0015 0.0057 0.0084
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.006 0.0841 0.2371
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.2127 0.6095
Echinococcus granulosus cysteine protease atg4b 0.006 0.0841 0.1332
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0196 0.031
Brugia malayi N-terminal motif family protein 0.0014 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0015 0.0057 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.16 0.3395
Brugia malayi Protein kinase domain containing protein 0.0091 0.1392 0.1392
Schistosoma mansoni nAChR subunit 0.0015 0.0057 0.009
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0761 0.2236
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0196 0.031
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1712 0.5045
Plasmodium vivax DNA repair protein REV1, putative 0.0031 0.0345 0.0969
Onchocerca volvulus 0.0015 0.0057 0.0084
Plasmodium falciparum glutathione reductase 0.0017 0.0083 0.017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus multilocularis geminin 0.037 0.6315 1
Echinococcus granulosus allatostatin A receptor 0.0023 0.0196 0.031
Brugia malayi AKH receptor 0.0023 0.0196 0.0196
Schistosoma mansoni opsin-like receptor 0.0023 0.0196 0.031
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0027 0.0027
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0014 0.0035 0.0052
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0014 0.0035 0.0023
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0444 0.0658
Trypanosoma brucei DNA polymerase IV, putative 0.0125 0.199 0.5688
Loa Loa (eye worm) hypothetical protein 0.0117 0.1854 0.275
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0388 0.0909
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.0196 0.0196
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0196 0.031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0132 0.2127 0.615
Loa Loa (eye worm) hypothetical protein 0.0153 0.2482 0.3682
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0633 0.0939
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0361 0.6161 0.9138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0196 0.031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Schistosoma mansoni phosphoglycerate kinase 0.02 0.3313 0.5245
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0337 0.0944
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0027 0.0042
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0021 0.0157 0.036
Trypanosoma brucei DNA damage repair protein, putative 0.0031 0.0345 0.0782
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus multilocularis chromobox protein 2 0.0013 0.0027 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Trichomonas vaginalis chromobox protein, putative 0.0049 0.066 0.1367
Echinococcus granulosus dna polymerase eta 0.0157 0.2557 0.4049
Brugia malayi neuropeptide F receptor 0.0023 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Brugia malayi hypothetical protein 0.0023 0.0196 0.0196
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0633 0.1704
Echinococcus multilocularis dna polymerase eta 0.0157 0.2557 0.4049
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0118 0.0187
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0196 0.031
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0345 0.0912
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0118 0.0187
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.1176 0.1862
Echinococcus multilocularis bloom syndrome protein 0.0046 0.0599 0.0948
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0014 0.0035 0.0023
Mycobacterium ulcerans glutaminase 0.0276 0.466 1
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0255 0.0694
Trypanosoma brucei unspecified product 0.007 0.1022 0.2802
Entamoeba histolytica hypothetical protein 0.0078 0.1176 0.3371
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0388 0.1098
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0101 0.1577 0.2338
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0196 0.031
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0124 0.0197
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0179 0.2954 0.2954
Echinococcus granulosus ras GTP exchange factor 0.0014 0.0035 0.0055
Mycobacterium ulcerans DNA polymerase IV 0.0132 0.2127 0.4466
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0345 0.0782
Schistosoma mansoni SET domain protein 0.0023 0.02 0.0316
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0196 0.0196
Echinococcus granulosus PWWP domain containing protein 2A 0.0021 0.0157 0.0249
Echinococcus granulosus Protein son of sevenless 0.0014 0.0035 0.0055
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0015 0.0057 0.009
Echinococcus granulosus g protein coupled receptor 0.0023 0.0196 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0599 0.1235
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0196 0.031
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0014 0.0035 0.0055
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0275 0.0535
Onchocerca volvulus 0.0023 0.0196 0.0291
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0118 0.0187
Giardia lamblia DINP protein human, muc B family 0.0109 0.1713 0.4862
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0196 0.031
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0196 0.031
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0005 0.0005
Echinococcus multilocularis dual specificity 0.0091 0.1392 0.2205
Schistosoma mansoni hypothetical protein 0.0021 0.0157 0.0249
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0196 0.031
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0599 0.0888
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0015 0.0057 0.009
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0014 0.0035 0.0023
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0196 0.0291
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0124 0.0124
Brugia malayi hypothetical protein 0.0021 0.0157 0.0157
Schistosoma mansoni hepatoma derived growth factor 0.0021 0.0157 0.0249
Brugia malayi Dopamine receptor protein 1 0.0023 0.0196 0.0196
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0014 0.0035 0.0017
Trypanosoma brucei DNA polymerase IV, putative 0.0132 0.2127 0.6095
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0019 0.0133 0.0197
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0118 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0201 0.0351
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0014 0.0035 0.0055
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0057 0.0057
Echinococcus granulosus dna polymerase kappa 0.0132 0.2127 0.3368
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.16 0.3395
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0196 0.031
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0207 0.3436 0.5097
Echinococcus multilocularis chromobox protein 1 0.0082 0.1233 0.1952
Brugia malayi Bloom's syndrome protein homolog 0.0046 0.0599 0.0599
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0104 0.0154
Echinococcus multilocularis glycine receptor subunit beta 0.0015 0.0057 0.009
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0196 0.031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus multilocularis glycine receptor subunit beta 0.0015 0.0057 0.009
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0083 0.0121
Schistosoma mansoni ras GTP exchange factor 0.0014 0.0035 0.0055
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0133 0.0133
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0133 0.0211
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0087 0.1326 0.3954
Loa Loa (eye worm) hypothetical protein 0.0036 0.0424 0.063
Echinococcus multilocularis sex peptide receptor 0.0023 0.0196 0.031
Giardia lamblia DNA damage repair protein 0.0031 0.0345 0.0782
Schistosoma mansoni amine GPCR 0.0023 0.0196 0.031
Schistosoma mansoni DNA helicase recq5 0.0019 0.0124 0.0197
Loa Loa (eye worm) hypothetical protein 0.0055 0.0761 0.1129
Brugia malayi hypothetical protein 0.0023 0.0196 0.0196
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0091 0.1392 0.3991
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0104 0.0165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Trypanosoma cruzi phosphoglycerate kinase, putative 0.02 0.3313 0.9637
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0196 0.031
Schistosoma mansoni hypothetical protein 0.0023 0.0196 0.031
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0196 0.031
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1712 0.5045
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0014 0.0035 0.0023
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0606 0.0898
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0015 0.0057 0.009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0084
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0444 0.0702
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0606 0.0959
Trypanosoma brucei phosphoglycerate kinase 0.0073 0.1084 0.2985
Loa Loa (eye worm) hypothetical protein 0.0019 0.0133 0.0197
Loa Loa (eye worm) LGC-31 protein 0.0015 0.0057 0.0084
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0104 0.0154
Echinococcus granulosus Chromobox protein 3 0.0013 0.0027 0.0042
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0072 0.1053 0.1667
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0331 0.0924
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0895 0.2423
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.02 0.3313 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0014 0.0035 0.0052
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0255 0.0668
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0015 0.0057 0.009
Entamoeba histolytica peptidase, C54 family 0.0023 0.0201 0.0509
Onchocerca volvulus 0.0023 0.0196 0.0291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0606 0.0959
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.006 0.0841 0.2262
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0196 0.0196
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.066 0.0979
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0291
Echinococcus multilocularis PWWP domain containing protein 2A 0.0021 0.0157 0.0249
Brugia malayi larval opioid receptor 0.0023 0.0196 0.0196
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0023 0.0196 0.0291
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0027 0.00000000046651
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0196 0.0291
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0133 0.0211
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0124 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0157 0.036
Onchocerca volvulus 0.0013 0.0027 0.004
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0014 0.0035 0.0055

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 51 nM Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain ChEMBL. 1967652
IC50 (binding) = 51 nM Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain ChEMBL. 1967652
IC50 (binding) = 248 nM Binding affinity was determined against Muscarinic acetylcholine receptor using [3H]-QNB as radioligand in rat brain. ChEMBL. 1967652
IC50 (binding) = 248 nM Binding affinity was determined against Muscarinic acetylcholine receptor using [3H]-QNB as radioligand in rat brain. ChEMBL. 1967652
IC50 (binding) = 300 nM Binding affinity for Dopamine receptor D2 using [3H]-spiperone in rat brain ChEMBL. 1967652
IC50 (binding) = 300 nM Binding affinity for Dopamine receptor D2 using [3H]-spiperone in rat brain ChEMBL. 1967652

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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