Detailed information for compound 309700

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 411.471 | Formula: C22H21NO5S
  • H donors: 1 H acceptors: 4 LogP: 3.44 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(C)[nH]c(c1C(=O)c1ccccc1S(=O)(=O)Cc1ccccc1)C
  • InChi: 1S/C22H21NO5S/c1-14-19(20(15(2)23-14)22(25)28-3)21(24)17-11-7-8-12-18(17)29(26,27)13-16-9-5-4-6-10-16/h4-12,23H,13H2,1-3H3
  • InChiKey: AEENMXNKFITPEV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0071 0.0485 0.1434
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.034 0.1005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0414 0.3177
Echinococcus granulosus dna polymerase kappa 0.0021 0.0054 0.0054
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0018 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.2576 0.763
Brugia malayi jmjC domain containing protein 0.0016 0.0012 0.001
Leishmania major hypothetical protein, conserved 0.0016 0.0012 0.0032
Schistosoma mansoni amine GPCR 0.075 0.6289 0.6288
Schistosoma mansoni survival motor neuron protein 0.0048 0.0286 0.0284
Onchocerca volvulus 0.075 0.6289 0.7683
Schistosoma mansoni hypothetical protein 0.0048 0.0286 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1082 0.108
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0075 0.0514 0.0602
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0226 0.0249
Schistosoma mansoni lipoxygenase 0.0019 0.0042 0.004
Echinococcus granulosus microtubule associated protein 2 0.0706 0.5907 0.5907
Schistosoma mansoni rab6-interacting 0.0019 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0126 0.0126
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.0884 0.0884
Echinococcus granulosus lamin dm0 0.0056 0.0353 0.0353
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0226 0.0249
Schistosoma mansoni biogenic amine receptor 0.075 0.6289 0.6288
Schistosoma mansoni hypothetical protein 0.0067 0.045 0.0448
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Loa Loa (eye worm) hypothetical protein 0.0175 0.1376 0.1376
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0002 0.0002
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0012 0.0012
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0799 0.2365
Echinococcus granulosus tm gpcr rhodopsin 0.075 0.6289 0.6289
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Toxoplasma gondii hypothetical protein 0.0056 0.0356 0.1048
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Onchocerca volvulus 0.075 0.6289 0.7683
Echinococcus granulosus allatostatin A receptor 0.075 0.6289 0.6289
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0054 0.034 0.4194
Echinococcus granulosus neuropeptide receptor A26 0.075 0.6289 0.6289
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Giardia lamblia Hypothetical protein 0.0054 0.034 0.4194
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.0107
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.034 0.0389
Brugia malayi MAP kinase sur-1 0.0101 0.0736 0.0734
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0012 0.0012
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.075 0.6289 0.6288
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0414 0.0412
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Echinococcus multilocularis rhodopsin orphan GPCR 0.075 0.6289 0.6289
Schistosoma mansoni ran 0.0022 0.0063 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.034 0.1005
Onchocerca volvulus 0.075 0.6289 0.7683
Echinococcus multilocularis allatostatin A receptor 0.075 0.6289 0.6289
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0126 0.034
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0226 0.0668
Mycobacterium tuberculosis Conserved protein 0.0071 0.0485 0.1284
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Loa Loa (eye worm) neuropeptide F receptor 0.075 0.6289 0.6289
Brugia malayi Inositol-1 0.0041 0.0226 0.0224
Leishmania major DNA polymerase kappa, putative 0.0021 0.0054 0.0158
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0054 0.0054
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0075 0.0514 0.0512
Echinococcus granulosus rhodopsin orphan GPCR 0.075 0.6289 0.6289
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0485 0.1434
Echinococcus multilocularis g protein coupled receptor 0.075 0.6289 0.6289
Schistosoma mansoni hypothetical protein 0.075 0.6289 0.6288
Echinococcus multilocularis lamin 0.0056 0.0353 0.0353
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0799 1
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0226 0.0226
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0799 0.0799
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0171 0.0171
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.034 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0226 0.0665
Brugia malayi isocitrate dehydrogenase 0.0017 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0122 0.0922 0.0922
Echinococcus granulosus biogenic amine 5HT receptor 0.075 0.6289 0.6289
Echinococcus multilocularis G-protein coupled receptor, putative 0.075 0.6289 0.6289
Echinococcus granulosus mitogen activated protein kinase 3 0.0101 0.0736 0.0736
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0414 0.1096
Brugia malayi Melatonin receptor type 1A 0.075 0.6289 0.6288
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0042 0.0042
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0485 0.1284
Trypanosoma brucei cAMP-specific phosphodiesterase 0.011 0.0819 0.242
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.011 0.0819 0.0819
Echinococcus multilocularis musashi 0.0056 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0051
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0012 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.075 0.6289 0.6289
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0382 0.0382
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0133
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.0181
Trypanosoma brucei hypothetical protein, conserved 0.0054 0.034 0.1002
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0101 0.0736 0.2178
Mycobacterium ulcerans beta-lactamase 0.0071 0.0485 0.3724
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0485 0.1434
Brugia malayi hypothetical protein 0.075 0.6289 0.6288
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0012 0.0028
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0071 0.0485 0.0485
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0012 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0126 0.0126
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.075 0.6289 0.6289
Schistosoma mansoni neuropeptide receptor 0.075 0.6289 0.6288
Loa Loa (eye worm) hypothetical protein 0.0071 0.0485 0.0485
Brugia malayi GnHR receptor homolog 0.075 0.6289 0.6288
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0042 0.0042
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0485 0.0485
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.011 0.0819 0.0976
Echinococcus granulosus neuropeptide Y receptor 0.075 0.6289 0.6289
Echinococcus granulosus adenylate cyclase 9 0.0083 0.0586 0.0586
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.075 0.6289 0.6289
Entamoeba histolytica hypothetical protein 0.0036 0.0182 0.1718
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.034 0.1005
Echinococcus granulosus somatostatin receptor 0.075 0.6289 0.6289
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.075 0.6289 0.6289
Echinococcus granulosus rhodopsin orphan GPCR 0.075 0.6289 0.6289
Onchocerca volvulus 0.0122 0.0922 0.1083
Schistosoma mansoni neuropeptide f receptor 76f 0.075 0.6289 0.6288
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0082 0.0072
Schistosoma mansoni neuropeptide receptor 0.075 0.6289 0.6288
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0142 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.034 0.0389
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.011 0.0819 0.0976
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0054 0.0154
Echinococcus multilocularis neuropeptide FF receptor 2 0.075 0.6289 0.6289
Brugia malayi hypothetical protein 0.0036 0.0182 0.018
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.075 0.6289 0.6289
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.075 0.6289 0.6289
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0485 0.1284
Brugia malayi jmjC domain containing protein 0.0016 0.0012 0.001
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.1143 0.1142
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.002 0.0051 0.013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.075 0.6289 0.6288
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0054 0.034 0.1005
Schistosoma mansoni hypothetical protein 0.075 0.6289 0.6288
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0126 0.0367
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0142 0.014
Brugia malayi RNA, U transporter 1 0.0084 0.0597 0.0595
Onchocerca volvulus 0.0056 0.0353 0.0383
Echinococcus multilocularis g-protein coupled receptor 0.075 0.6289 0.6289
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0132 0.013
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0042 0.0042
Mycobacterium leprae Probable lipase LipE 0.0071 0.0485 0.6058
Schistosoma mansoni hypothetical protein 0.0036 0.0182 0.018
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Entamoeba histolytica hypothetical protein 0.0036 0.0182 0.1718
Mycobacterium ulcerans putative regulatory protein 0.002 0.0051 0.0376
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0485 0.0483
Brugia malayi hypothetical protein 0.0235 0.1883 0.1881
Brugia malayi Dopamine receptor 0.075 0.6289 0.6288
Onchocerca volvulus 0.075 0.6289 0.7683
Echinococcus multilocularis rhodopsin orphan GPCR 0.075 0.6289 0.6289
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0054 0.034 0.034
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0012 0.001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0182 0.0182
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.019 0.0499
Onchocerca volvulus 0.0039 0.0208 0.0204
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0998 0.8401 0.8401
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.034 0.1002
Brugia malayi MH2 domain containing protein 0.0124 0.0936 0.0934
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0356 0.0408
Schistosoma mansoni amine GPCR 0.075 0.6289 0.6288
Leishmania major hypothetical protein, conserved 0.0054 0.034 0.1005
Echinococcus multilocularis alpha 1A adrenergic receptor 0.075 0.6289 0.6289
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0054 0.0158
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0101 0.0736 0.2178
Echinococcus multilocularis lamin dm0 0.0056 0.0353 0.0353
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 0.2579 0.2579
Echinococcus multilocularis g protein coupled receptor 0.075 0.6289 0.6289
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0142 0.0142
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0054 0.034 1
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.034 0.1005
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0485 0.0483
Schistosoma mansoni growth hormone secretagogue receptor 0.075 0.6289 0.6288
Loa Loa (eye worm) hypothetical protein 0.0026 0.0098 0.0098
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0414 0.3177
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0054 0.034 0.034
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Trypanosoma brucei unspecified product 0.0021 0.0054 0.0154
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0853 0.7165 0.7165
Echinococcus granulosus histone lysine methyltransferase setb 0.0122 0.0922 0.0922
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0715 0.0714
Loa Loa (eye worm) beta-lactamase 0.0071 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0012
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0799 0.0799
Onchocerca volvulus 0.075 0.6289 0.7683
Schistosoma mansoni alpha-1 adrenergic receptor 0.075 0.6289 0.6288
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0142 0.0142
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0054 0.0158
Trichomonas vaginalis esterase, putative 0.0071 0.0485 0.0566
Plasmodium vivax SET domain protein, putative 0.0122 0.0922 0.2707
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0485 0.0566
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0101 0.0736 0.2178
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0485 0.1284
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.075 0.6289 0.6289
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0715 0.0714
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0353 0.0353
Plasmodium falciparum GAF domain-related protein, putative 0.002 0.0051 0.1194
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0485 0.0566
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.045 0.0448
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.034 0.1002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0485 0.3724
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Onchocerca volvulus 0.075 0.6289 0.7683
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1082 0.108
Leishmania major DNA polymerase eta, putative 0.0021 0.0054 0.0158
Echinococcus multilocularis mitogen activated protein kinase 3 0.0101 0.0736 0.0736
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0012 0.0012
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0339 0.0339
Schistosoma mansoni myosin xvIII 0.075 0.6289 0.6288
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0455 0.3761 1
Brugia malayi neuropeptide F receptor 0.075 0.6289 0.6288
Echinococcus granulosus snurportin 1 0.0316 0.2579 0.2579
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Echinococcus multilocularis rhodopsin orphan GPCR 0.075 0.6289 0.6289
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1154 0.3418
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0409 0.3376 0.3376
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0063 0.0063
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0054 0.034 0.0338
Echinococcus granulosus sex peptide receptor 0.075 0.6289 0.6289
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.1185 1 1
Onchocerca volvulus 0.075 0.6289 0.7683
Brugia malayi RE15519p 0.075 0.6289 0.6288
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0042 0.0927
Brugia malayi AKH receptor 0.075 0.6289 0.6288
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0339 0.0339
Brugia malayi hypothetical protein 0.075 0.6289 0.6288
Loa Loa (eye worm) cytochrome P450 0.0015 0.0002 0.0002
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0218 0.2205
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0485 0.1284
Onchocerca volvulus 0.075 0.6289 0.7683
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.075 0.6289 0.6288
Schistosoma mansoni hypothetical protein 0.0019 0.0042 0.004
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0054 0.034 0.034
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0018 0.02
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0018 0.0048
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0382 0.0382
Leishmania major hypothetical protein, conserved 0.0054 0.034 0.1005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.075 0.6289 0.6288
Plasmodium falciparum phosphodiesterase delta, putative 0.0054 0.034 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.075 0.6289 0.6289
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0249 0.0733
Loa Loa (eye worm) acetyltransferase 0.0148 0.1143 0.1143
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0799 0.2362
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0082 0.0072
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Echinococcus multilocularis rhodopsin orphan GPCR 0.075 0.6289 0.6289
Echinococcus multilocularis g protein coupled receptor 0.075 0.6289 0.6289
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.011 0.0819 0.0976
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.013 0.0379
Plasmodium falciparum phosphodiesterase gamma, putative 0.0054 0.034 1
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.1143 0.1142
Plasmodium vivax phosphodiesterase gamma, putative 0.0054 0.034 0.0976
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0054 0.0054
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0083 0.0586 0.0669
Schistosoma mansoni loxhd1 0.0019 0.0042 0.004
Giardia lamblia hypothetical protein 0.0054 0.034 0.4194
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.013 0.0379
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0871 0.7323 0.7323
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.011 0.0819 0.0976
Brugia malayi hypothetical protein 0.0121 0.091 0.0908
Echinococcus granulosus neuropeptides capa receptor 0.075 0.6289 0.6289
Echinococcus granulosus intermediate filament protein 0.0056 0.0353 0.0353
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0012 0.001
Trypanosoma brucei protein kinase, putative 0.0101 0.0736 0.2175
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0414 0.3177
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.009 0.0645 0.0763
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0054 0.0038
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Schistosoma mansoni hypothetical protein 0.0031 0.0142 0.014
Mycobacterium ulcerans hypothetical protein 0.0166 0.1299 1
Echinococcus multilocularis serotonin receptor 0.075 0.6289 0.6289
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0054 0.034 0.0338
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0054 0.0402
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0249 0.0707
Schistosoma mansoni hypothetical protein 0.075 0.6289 0.6288
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0409 0.3376 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0126 0.3485
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0502 0.0502
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0012 0.0012
Schistosoma mansoni neuropeptide F-like receptor 0.075 0.6289 0.6288
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0054 0.0154
Echinococcus multilocularis microtubule associated protein 2 0.0706 0.5907 0.5907
Brugia malayi sulfakinin receptor protein 0.075 0.6289 0.6288
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1082 0.1082
Brugia malayi hypothetical protein 0.075 0.6289 0.6288
Onchocerca volvulus 0.0071 0.0485 0.0545
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0353 0.0351
Schistosoma mansoni histamine h1 receptor 0.075 0.6289 0.6288
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0485 0.0485
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0226 0.0668
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0012 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0799 0.0952
Echinococcus multilocularis neuropeptide receptor 0.075 0.6289 0.6289
Brugia malayi Importin beta-1 subunit 0.003 0.013 0.0128
Onchocerca volvulus 0.075 0.6289 0.7683
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0226 0.173
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Toxoplasma gondii hypothetical protein 0.0051 0.0312 0.0919
Brugia malayi Protein kinase domain containing protein 0.0015 0.0007 0.0005
Schistosoma mansoni microtubule-associated protein tau 0.0706 0.5907 0.5906
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0042
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0075 0.0514 0.0512
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.075 0.6289 0.6289
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.034 0.0389
Mycobacterium ulcerans putative regulatory protein 0.002 0.0051 0.0376
Brugia malayi larval opioid receptor 0.075 0.6289 0.6288
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0018 0.0016
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0257 0.0754
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.013 0.0379
Mycobacterium tuberculosis Conserved protein 0.0071 0.0485 0.1284
Echinococcus granulosus G protein coupled receptor 139 0.075 0.6289 0.6289
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0054 0.0158
Brugia malayi hypothetical protein 0.075 0.6289 0.6288
Brugia malayi Serotonin receptor 0.075 0.6289 0.6288
Trichomonas vaginalis ran, putative 0.0022 0.0063 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0054 0.0158
Loa Loa (eye worm) hypothetical protein 0.003 0.013 0.013
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.075 0.6289 0.6289
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0409 0.3376 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0042 0.0042
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.075 0.6289 0.6288
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0075 0.0514 0.0512
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0054 0.034 0.1002
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0075 0.0514 0.0514
Brugia malayi G protein-coupled receptor 0.075 0.6289 0.6288
Leishmania major cytochrome p450-like protein 0.0015 0.0002 0.0004
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0018 0.0051
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0414 0.1221
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.0185
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0018 0.0043
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0042 0.0042
Echinococcus granulosus geminin 0.0182 0.1433 0.1433
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.011 0.0819 0.2423
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0054 0.034 0.0389
Entamoeba histolytica hypothetical protein 0.0036 0.0182 0.1718
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0018 0.0051
Echinococcus multilocularis dro:myosuppressin receptor 0.075 0.6289 0.6289
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0736 0.0874
Brugia malayi hypothetical protein 0.075 0.6289 0.6288
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.011 0.0819 0.0976
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0075 0.0514 0.0602
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.009 0.0645 0.1908
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0054 0.034 1
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0485 0.3724
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0799 0.0952
Schistosoma mansoni ran 0.0022 0.0063 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.075 0.6289 0.6289
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.075 0.6289 0.6289
Echinococcus granulosus hypothetical protein 0.075 0.6289 0.6289
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.009 0.0645 0.0763
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0122 0.0922 0.0922
Echinococcus granulosus rhodopsin orphan GPCR 0.075 0.6289 0.6289
Mycobacterium tuberculosis Conserved protein 0.0071 0.0485 0.1284
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0054 0.0154
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0257 0.0757
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0409 0.3376 1
Mycobacterium ulcerans lipase LipD 0.0071 0.0485 0.3724
Echinococcus granulosus rhodopsin orphan GPCR 0.075 0.6289 0.6289
Loa Loa (eye worm) G-protein coupled receptor 0.075 0.6289 0.6289
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0799 0.0799
Brugia malayi Dopamine receptor protein 2 0.075 0.6289 0.6288
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0208 0.0206
Brugia malayi Cytochrome P450 family protein 0.0034 0.0171 0.0169
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0054 0.034 0.0338
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Schistosoma mansoni neuropeptide receptor 0.075 0.6289 0.6288
Echinococcus granulosus peptide allatostatin:somatostatin 0.075 0.6289 0.6289
Schistosoma mansoni amine GPCR 0.075 0.6289 0.6288
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0054 0.0402
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0485 0.0566
Schistosoma mansoni neuropeptide F-like receptor 0.075 0.6289 0.6288
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.1299 0.345
Schistosoma mansoni hypothetical protein 0.0182 0.1433 0.1431
Loa Loa (eye worm) hypothetical protein 0.0235 0.1883 0.1883
Brugia malayi hypothetical protein 0.0019 0.0042 0.004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.075 0.6289 0.6289
Plasmodium vivax importin-beta 2, putative 0.003 0.013 0.0352
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0799 0.0952
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0799 0.212
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0485 0.0566
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0936 0.0936
Brugia malayi gonadotropin-releasing hormone receptor 2 0.075 0.6289 0.6288
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0012 0.0028
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.075 0.6289 0.6288
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0107 0.0107
Brugia malayi phosphofructokinase 0.0108 0.0799 0.0797
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0799 0.0799
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1082 0.1082
Onchocerca volvulus 0.0048 0.0286 0.03
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0208 0.1585
Brugia malayi 6-phosphofructokinase 0.0108 0.0799 0.0797
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0054 0.0052
Echinococcus multilocularis RUN 0.0019 0.0042 0.0042
Brugia malayi PAS domain containing protein 0.0052 0.0324 0.0322
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.075 0.6289 0.6288
Plasmodium falciparum importin beta, putative 0.003 0.013 0.3607
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0012 0.0032
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0736 0.0874
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0002 0.0002
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0054 0.034 0.0338
Loa Loa (eye worm) inositol-1 0.0041 0.0226 0.0226
Schistosoma mansoni biogenic amine (dopamine) receptor 0.075 0.6289 0.6288
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0142 0.0142
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.002 0.0051 0.013
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0101 0.0736 0.2178
Loa Loa (eye worm) hypothetical protein 0.0026 0.0098 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0922 0.092
Loa Loa (eye worm) hypothetical protein 0.0098 0.0715 0.0715
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.075 0.6289 0.6288
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.075 0.6289 0.6289
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0018 0.0051
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0054 0.0054
Toxoplasma gondii hypothetical protein 0.002 0.0051 0.0144
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0142 0.014
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0054 0.034 0.034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.075 0.6289 0.6288
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.1883 0.1883
Loa Loa (eye worm) hypothetical protein 0.0079 0.0556 0.0556
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Echinococcus multilocularis sex peptide receptor 0.075 0.6289 0.6289
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.034 0.1003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0071 0.0485 0.0485
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0126 0.3485
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.075 0.6289 0.6289
Echinococcus multilocularis neuropeptides capa receptor 0.075 0.6289 0.6289
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.0185
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0002 0.0004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.075 0.6289 0.6289
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0736 0.0734
Loa Loa (eye worm) hypothetical protein 0.0054 0.034 0.034
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0122 0.0922 0.0922
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0101 0.0736 0.2178
Brugia malayi ORL1-like opioid receptor 0.075 0.6289 0.6288
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.075 0.6289 0.6288
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0054 0.034 0.0338
Echinococcus multilocularis rhodopsin orphan GPCR 0.075 0.6289 0.6289
Echinococcus granulosus adenylate cyclase type IX 0.0117 0.0874 0.0874
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.075 0.6289 0.7683
Echinococcus granulosus rhodopsin orphan GPCR 0.075 0.6289 0.6289
Brugia malayi Pre-SET motif family protein 0.0122 0.0922 0.092
Onchocerca volvulus 0.075 0.6289 0.7683
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0736 0.0874
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0249 0.0278
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.1154 0.3415
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0054 0.034 0.0338
Onchocerca volvulus 0.075 0.6289 0.7683
Schistosoma mansoni polycystin 1-related 0.0019 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0012
Onchocerca volvulus 0.0071 0.0485 0.0545
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0485 0.1284
Onchocerca volvulus 0.075 0.6289 0.7683
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0409 0.3376 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0126 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.075 0.6289 0.6289
Echinococcus granulosus tm gpcr rhodopsin 0.075 0.6289 0.6289
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0126 0.0126
Schistosoma mansoni lamin 0.0056 0.0353 0.0351
Onchocerca volvulus 0.0971 0.8173 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0054
Echinococcus granulosus neuropeptides capa receptor 0.075 0.6289 0.6289
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0054 0.0154
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0414 0.0412
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0257 0.0757
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0286 0.0284
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1082 0.1082
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0054 0.0052
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0054 0.0158
Loa Loa (eye worm) G-protein coupled receptor 0.075 0.6289 0.6289
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0485 0.0485
Echinococcus granulosus rhodopsin orphan GPCR 0.075 0.6289 0.6289
Echinococcus multilocularis mitogen activated protein kinase 0.0101 0.0736 0.0736
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0226 0.0249
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0063 0.0181
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0799 0.0797
Leishmania major cAMP-specific phosphodiesterase, putative 0.0054 0.034 0.1005
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.1185 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0054 0.034 0.0389
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.034 0.0389
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0485 0.1431
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0012 0.0012
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0054 0.0054
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0409 0.3376 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.075 0.6289 0.6288
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.075 0.6289 0.6288
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0054 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1082 0.108
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0799 1
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.011 0.0819 0.0976
Echinococcus multilocularis fmrfamide receptor 0.075 0.6289 0.6289
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0126 0.034
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0257 0.0757
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0018 0.0018
Echinococcus granulosus g protein coupled receptor 0.075 0.6289 0.6289
Trichomonas vaginalis set domain proteins, putative 0.0971 0.8172 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.075 0.6289 0.6288
Onchocerca volvulus 0.0071 0.0485 0.0545
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0012
Echinococcus multilocularis orexin receptor type 2 0.075 0.6289 0.6289
Brugia malayi neuropeptide F receptor 0.075 0.6289 0.6288
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Loa Loa (eye worm) adenylyl cyclase 3 0.0196 0.1553 0.1553
Echinococcus granulosus neuropeptide FF receptor 2 0.075 0.6289 0.6289
Echinococcus granulosus serotonin receptor 0.075 0.6289 0.6289
Loa Loa (eye worm) hypothetical protein 0.0315 0.2568 0.2568
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0485 0.1284
Echinococcus multilocularis neuropeptide s receptor 0.075 0.6289 0.6289
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0054 0.0154
Loa Loa (eye worm) melatonin receptor type 1A 0.075 0.6289 0.6289
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0182 0.018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0922 0.092
Schistosoma mansoni amine GPCR 0.075 0.6289 0.6288
Echinococcus granulosus 7tm_1 domain containing protein 0.075 0.6289 0.6289
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0799 0.0799
Leishmania major cytochrome p450-like protein 0.0015 0.0002 0.0004
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.011 0.0819 0.2423
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0485 0.0566
Echinococcus multilocularis rhodopsin orphan GPCR 0.075 0.6289 0.6289
Echinococcus multilocularis fmrfamide receptor 0.075 0.6289 0.6289
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0012 0.0012
Schistosoma mansoni biogenic amine receptor 0.075 0.6289 0.6288
Schistosoma mansoni lamin 0.0056 0.0353 0.0351
Echinococcus multilocularis G protein coupled receptor 139 0.075 0.6289 0.6289
Echinococcus multilocularis dna polymerase eta 0.0021 0.0054 0.0054
Echinococcus granulosus 7TM GPCR rhodopsin 0.075 0.6289 0.6289
Brugia malayi G protein-coupled receptor F59B2.13 0.075 0.6289 0.6288
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0054 0.0139
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.075 0.6289 0.6288
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0054 0.0154
Schistosoma mansoni hypothetical protein 0.0031 0.0142 0.014
Echinococcus granulosus neuropeptide Y receptor 0.075 0.6289 0.6289
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1154 0.3418
Schistosoma mansoni opsin-like receptor 0.075 0.6289 0.6288
Toxoplasma gondii GAF domain-containing protein 0.002 0.0051 0.0144
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.075 0.6289 0.6288
Brugia malayi Serotonin receptor 0.075 0.6289 0.6288
Echinococcus multilocularis neuropeptides capa receptor 0.075 0.6289 0.6289
Brugia malayi beta-lactamase family protein 0.0071 0.0485 0.0483
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Brugia malayi jmjC domain containing protein 0.0059 0.0382 0.038
Entamoeba histolytica Ran family GTPase 0.0022 0.0063 0.0122
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0126 0.0367
Echinococcus granulosus g protein coupled receptor 0.075 0.6289 0.6289
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0002 0.0004
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0054 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.075 0.6289 0.6288
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0936 0.0936
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.034 1
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.1883 0.1883
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0126 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.011 0.0819 0.0976
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.011 0.0819 0.0817
Echinococcus granulosus fmrfamide receptor 0.075 0.6289 0.6289
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0409 0.3376 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0054 0.034 0.0338
Echinococcus granulosus neuropeptide receptor 0.075 0.6289 0.6289
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0485 0.1284
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0101 0.0736 0.2175
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0249 0.0733
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.1185 1 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.0051 0.0376
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0054 0.0154
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0101 0.0736 0.2178
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0226 0.0226
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0226 0.2312
Echinococcus granulosus mitogen activated protein kinase 0.0101 0.0736 0.0736
Loa Loa (eye worm) hypothetical protein 0.0056 0.0353 0.0353
Schistosoma mansoni hypothetical protein 0.0182 0.1433 0.1431
Echinococcus granulosus single minded 2 0.0039 0.0208 0.0208
Echinococcus granulosus alpha 1A adrenergic receptor 0.075 0.6289 0.6289
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.011 0.0819 0.0976
Onchocerca volvulus 0.075 0.6289 0.7683
Echinococcus granulosus neuropeptide s receptor 0.075 0.6289 0.6289
Echinococcus multilocularis somatostatin receptor 0.075 0.6289 0.6289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.075 0.6289 0.6288
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0054 0.0154
Schistosoma mansoni opsin-like receptor 0.075 0.6289 0.6288
Schistosoma mansoni peptide (allatostatin)-like receptor 0.075 0.6289 0.6288
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Brugia malayi jmjC domain containing protein 0.0016 0.0012 0.001
Echinococcus granulosus neuropeptide receptor 0.075 0.6289 0.6289
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0054 0.034 0.034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0485 0.0483
Brugia malayi beta-lactamase 0.0071 0.0485 0.0483
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0736 0.0874
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0122 0.0922 0.2728
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0002 0.0002
Echinococcus granulosus g-protein coupled receptor 0.075 0.6289 0.6289
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0799 0.6146
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0012 0.0028
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0054 0.034 0.0338
Schistosoma mansoni hypothetical protein 0.0031 0.0142 0.014
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.011 0.0819 0.0976
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0054 0.0154
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0054 0.034 0.0338
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0054 0.034 0.0389
Toxoplasma gondii hypothetical protein 0.002 0.0051 0.0144
Brugia malayi jmjC domain containing protein 0.0059 0.0382 0.038
Brugia malayi hypothetical protein 0.075 0.6289 0.6288
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0799 0.0797
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0126 0.0126
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0382 0.0382
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0126 0.1055
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0054 0.034 0.0389
Brugia malayi intermediate filament protein 0.0056 0.0353 0.0351
Schistosoma mansoni inositol monophosphatase 0.0041 0.0226 0.0224
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0012 0.0012
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.034 0.0389
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0054 0.034 0.0976
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0012 0.001
Onchocerca volvulus 0.075 0.6289 0.7683
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0356 0.0408
Onchocerca volvulus 0.075 0.6289 0.7683
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0382 0.038
Plasmodium vivax hypothetical protein, conserved 0.002 0.0051 0.0117
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0018 0.0018
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.2576 0.763
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0002 0.0004
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.011 0.0819 0.0976
Schistosoma mansoni lipoxygenase 0.0054 0.0339 0.0337
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0012 0.0032
Brugia malayi 6-phosphofructokinase 0.0108 0.0799 0.0797
Schistosoma mansoni rab6-interacting 0.0019 0.0042 0.004
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0054 0.0154
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Schistosoma mansoni inositol monophosphatase 0.0041 0.0226 0.0224
Echinococcus multilocularis adenylate cyclase type IX 0.0117 0.0874 0.0874
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0316 0.2576 0.7629
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0409 0.3376 0.3376
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0799 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0126 0.0126
Schistosoma mansoni biogenic amine (5HT) receptor 0.075 0.6289 0.6288
Echinococcus multilocularis geminin 0.0182 0.1433 0.1433
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0799 1
Echinococcus granulosus rhodopsin orphan GPCR 0.075 0.6289 0.6289
Loa Loa (eye worm) hypothetical protein 0.0071 0.0485 0.0485
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.011 0.0819 0.0976
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0208 0.0208
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0054 0.034 0.0976
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.075 0.6289 0.6289
Brugia malayi putative neuropeptide receptor NPR1 0.075 0.6289 0.6288
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0075 0.0514 0.0514
Brugia malayi Dopamine receptor protein 1 0.075 0.6289 0.6288
Schistosoma mansoni biogenic amine (5HT) receptor 0.075 0.6289 0.6288
Loa Loa (eye worm) TYRA-2 protein 0.075 0.6289 0.6289
Leishmania major mitochondrial DNA polymerase beta 0.0316 0.2576 0.763
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0054 0.034 0.034
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0819 0.0976
Echinococcus granulosus phd:f box containing protein 0.0016 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0054 0.034 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0054 0.0154
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0382 0.0382
Brugia malayi Adenylyl cyclase protein 0.0083 0.0586 0.0584
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.1143 0.1143
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0132 0.0132
Onchocerca volvulus Neuropeptide F receptor homolog 0.075 0.6289 0.7683
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0018 0.0048
Loa Loa (eye worm) PDE1B protein 0.1185 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0075 0.0514 0.0602
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0485 0.6058
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Brugia malayi follicle stimulating hormone receptor 0.0998 0.8401 0.8401
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0042 0.0042
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0018 0.0016
Brugia malayi jmjC domain containing protein 0.0016 0.0012 0.001
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0218 0.6296
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0101 0.0736 0.0736
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0226 0.0665
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.075 0.6289 0.6289
Echinococcus multilocularis adenylate cyclase 9 0.0083 0.0586 0.0586
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0126 0.0126
Toxoplasma gondii ABC1 family protein 0.0071 0.0485 0.1431
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0715 0.0715
Leishmania major GTP-binding protein, putative 0.0022 0.0063 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.034 0.1005
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0054 0.034 0.0389
Brugia malayi hypothetical protein 0.075 0.6289 0.6288
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.075 0.6289 0.6288
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0922 0.092
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.011 0.0819 0.0819
Leishmania major importin beta-1 subunit, putative 0.0024 0.0082 0.0241
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0054 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0054 0.0154
Trypanosoma brucei cAMP-specific phosphodiesterase 0.011 0.0819 0.242
Echinococcus granulosus tachykinin peptides receptor 99D 0.075 0.6289 0.6289
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Loa Loa (eye worm) hypothetical protein 0.0071 0.0485 0.0485
Echinococcus granulosus GPCR family 2 0.0031 0.0142 0.0142
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0054 0.034 0.0338
Onchocerca volvulus 0.0083 0.0586 0.0669
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0324 0.0322
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0063 0.0063
Echinococcus granulosus tm gpcr rhodopsin 0.075 0.6289 0.6289
Echinococcus multilocularis importin subunit beta 1 0.003 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0054 0.034 0.034
Brugia malayi Doublecortin family protein 0.0019 0.0042 0.004
Mycobacterium leprae conserved hypothetical protein 0.002 0.0051 0.0611
Onchocerca volvulus 0.075 0.6289 0.7683
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0485 0.1407
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0122 0.0922 0.092
Echinococcus multilocularis neuropeptide receptor 0.075 0.6289 0.6289
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Echinococcus multilocularis serotonin receptor 0.075 0.6289 0.6289
Mycobacterium ulcerans hypothetical protein 0.0071 0.0485 0.3724
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0101 0.0736 0.2175
Schistosoma mansoni rhodopsin-like orphan GPCR 0.075 0.6289 0.6288
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0126 0.0367
Schistosoma mansoni DNA polymerase eta 0.0021 0.0054 0.0052
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0226 0.0668
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Brugia malayi beta-lactamase family protein 0.0071 0.0485 0.0483
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0054 0.0158
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0414 0.0414
Echinococcus multilocularis neuropeptide receptor A26 0.075 0.6289 0.6289
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0002 0.0004
Echinococcus granulosus lamin 0.0056 0.0353 0.0353
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.034 0.0389
Echinococcus multilocularis snurportin 1 0.0316 0.2579 0.2579
Schistosoma mansoni hypothetical protein 0.0316 0.2579 0.2578
Echinococcus granulosus RUN 0.0019 0.0042 0.0042
Brugia malayi Tachykinin-like peptides receptor 99D 0.075 0.6289 0.6288
Schistosoma mansoni importin beta-1 0.003 0.013 0.0128
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Schistosoma mansoni single-minded 0.0052 0.0324 0.0322
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.034 0.1005
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0353 0.0353
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0067 0.045 0.045
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0799 0.0952
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0018 0.0018
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0054 0.034 0.1002
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.075 0.6289 0.6289
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0107 0.0107
Echinococcus granulosus biogenic amine 5HT receptor 0.075 0.6289 0.6289
Brugia malayi hypothetical protein 0.0175 0.1376 0.1374
Echinococcus granulosus dro:myosuppressin receptor 0.075 0.6289 0.6289
Echinococcus granulosus orexin receptor type 2 0.075 0.6289 0.6289
Echinococcus multilocularis neuropeptide Y receptor 0.075 0.6289 0.6289
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0249 0.0249
Schistosoma mansoni intermediate filament proteins 0.0056 0.0353 0.0351
Schistosoma mansoni neuropeptide receptor 0.075 0.6289 0.6288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1082 0.1082
Schistosoma mansoni hypothetical protein 0.0031 0.0142 0.014
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Echinococcus granulosus dna polymerase eta 0.0021 0.0054 0.0054
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0063 0.0154
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0054 0.034 0.0338
Echinococcus granulosus importin subunit beta 1 0.003 0.013 0.013
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.1108 0.1108
Schistosoma mansoni opsin-like receptor 0.075 0.6289 0.6288
Echinococcus multilocularis neuropeptide Y receptor 0.075 0.6289 0.6289
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0061
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0126 0.0126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.075 0.6289 0.6288
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0054 0.034 0.034
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.034 0.0389
Echinococcus multilocularis biogenic amine (5HT) receptor 0.075 0.6289 0.6289
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Brugia malayi Pre-SET motif family protein 0.0853 0.7165 0.7165
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0409 0.3376 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0018 0.0018
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Brugia malayi hypothetical protein 0.075 0.6289 0.6288
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0054 0.0139
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0012 0.001
Brugia malayi hypoxia-induced factor 1 0.0162 0.126 0.1258
Brugia malayi hypothetical protein 0.0019 0.0042 0.004
Schistosoma mansoni adenoreceptor 0.075 0.6289 0.6288
Brugia malayi hypothetical protein 0.075 0.6289 0.6288
Entamoeba histolytica hypothetical protein 0.0024 0.0082 0.0377
Loa Loa (eye worm) neuropeptide F receptor 0.075 0.6289 0.6289
Schistosoma mansoni biogenic amine receptor 0.075 0.6289 0.6288
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0082 0.0072
Schistosoma mansoni amine GPCR 0.075 0.6289 0.6288
Onchocerca volvulus 0.075 0.6289 0.7683
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.1082 0.108
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.075 0.6289 0.6289
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0054 0.0154
Loa Loa (eye worm) hypoxia-induced factor 1 0.0162 0.126 0.126
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.019 0.2355
Schistosoma mansoni rhodopsin-like orphan GPCR 0.075 0.6289 0.6288
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.075 0.6289 0.6288
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.075 0.6289 0.6289
Loa Loa (eye worm) hypothetical protein 0.0083 0.0586 0.0586
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0075 0.0514 0.0514
Echinococcus granulosus g protein coupled receptor 0.075 0.6289 0.6289
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0356 0.0408
Loa Loa (eye worm) hypothetical protein 0.0054 0.034 0.034
Brugia malayi hypothetical protein 0.075 0.6289 0.6288
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0018 0.0048
Brugia malayi Serotonin/octopamine receptor family protein 7 0.075 0.6289 0.6288
Schistosoma mansoni biogenic amine (dopamine) receptor 0.075 0.6289 0.6288
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0042 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.075 0.6289 0.6289
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.1082 0.1082
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0414 0.0414
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0042 0.0091
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.011 0.0819 0.2423
Giardia lamblia Kinase, CMGC MAPK 0.0101 0.0736 1
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0218 0.2409
Onchocerca volvulus 0.0056 0.0353 0.0383
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0799 1
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0382 0.0382
Echinococcus multilocularis tachykinin peptides receptor 99D 0.075 0.6289 0.6289
Brugia malayi G-protein coupled receptor 0.075 0.6289 0.6288
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0082 0.0241
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0799 0.2365
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0226 0.5
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0018 0.0048
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0819 0.0976
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0054 0.034 0.1005
Onchocerca volvulus 0.0079 0.0556 0.0632
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0083 0.0586 0.0669
Brugia malayi putative neuropeptide receptor 0.075 0.6289 0.6288
Echinococcus granulosus Solute carrier family 22 5 0.1085 0.9146 0.9146
Brugia malayi G-protein coupled receptor 0.075 0.6289 0.6288
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0485 0.0485
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0382 0.038
Echinococcus multilocularis GPCR, family 2 0.0031 0.0142 0.0142
Entamoeba histolytica hypothetical protein 0.0036 0.0182 0.1718
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.1573
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0051 0.0034
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0382 0.038
Loa Loa (eye worm) hypothetical protein 0.0055 0.0345 0.0345
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0126 0.0965
Leishmania major cytochrome p450-like protein 0.0015 0.0002 0.0004
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0414 0.1224
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0054 0.0052
Echinococcus multilocularis 0.0015 0.0002 0.0002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0249 0.0278
Schistosoma mansoni rhodopsin-like orphan GPCR 0.075 0.6289 0.6288
Loa Loa (eye worm) hypothetical protein 0.075 0.6289 0.6289

Activities

Activity type Activity value Assay description Source Reference
clogP = 2.16 Calculated partition coefficient (clogP) (relative to BAY K 8644) ChEMBL. 8151623
CMR (ADMET) = 10.93 CMR value (relative to BAY K 8644) ChEMBL. 8151623
EC50 (functional) = 0.021 Effective concentration required for force of contraction relative to BAY K 8644 ChEMBL. 8151623

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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