Detailed information for compound 337043

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 222.156 | Formula: C7H13NO5P---
  • H donors: 0 H acceptors: 5 LogP: -1.52 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(P(=O)([O-])[O-])CCN(C(=O)C)[O-]
  • InChi: 1S/C7H15NO5P/c1-3-7(14(11,12)13)4-5-8(10)6(2)9/h7H,3-5H2,1-2H3,(H2,11,12,13)/q-1/p-2
  • InChiKey: XSAJPLJBHWACGB-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) blistered cuticle protein 3 0.0067 0.0289 0.2198
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0062 0.038
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0802 0.4512
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0306 0.1672
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0079 0.0359 0.2009
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0446 0.2735
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.1308 1
Echinococcus granulosus zinc finger protein 0.0021 0.0014 0.0045
Schistosoma mansoni bromodomain containing protein 0.0068 0.0297 0.1616
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0446 0.2735
Plasmodium vivax hypothetical protein, conserved 0.0039 0.012 0.0199
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0802 0.4512
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0446 0.2735
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0446 1
Brugia malayi Fli-1 protein 0.0228 0.1252 0.957
Toxoplasma gondii ABC1 family protein 0.0039 0.012 0.0199
Echinococcus multilocularis lamin dm0 0.006 0.0248 0.024
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0802 0.4512
Loa Loa (eye worm) hypothetical protein 0.0153 0.0802 0.6128
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.0408
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0062 0.041
Brugia malayi Peroxidasin 0.0067 0.0289 0.2208
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0196 0.1443
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.2198
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.1308 0.1301
Loa Loa (eye worm) hypothetical protein 0.0048 0.0177 0.1342
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.3004 1
Schistosoma mansoni hypothetical protein 0.0048 0.0177 0.0935
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0595 0.3325
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0153 0.0802 0.0795
Loa Loa (eye worm) hypothetical protein 0.0059 0.0242 0.1835
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0248 0.1886
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0153 0.0802 0.4512
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3004 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0062 0.0053
Loa Loa (eye worm) hypothetical protein 0.0039 0.012 0.0907
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0153 0.0802 0.6133
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0105 0.0741
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0153 0.0802 0.4512
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0239 0.1771
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0118 0.0595 0.0587
Onchocerca volvulus 0.0051 0.0196 0.1036
Echinococcus multilocularis transmembrane protease serine 3 0.0153 0.0802 0.0795
Loa Loa (eye worm) hypothetical protein 0.0153 0.0802 0.6128
Brugia malayi hypothetical protein 0.0237 0.1308 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0153 0.0802 0.4512
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0118 0.0595 0.4514
Onchocerca volvulus 0.0067 0.0289 0.1784
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0446 0.2735
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0595 0.3325
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.0337 0.0329
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0105 0.0096
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0153 0.0802 0.4512
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3004 0.5
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0239 0.023
Brugia malayi hypothetical protein 0.0036 0.0105 0.08
Brugia malayi Pre-SET motif family protein 0.003 0.0067 0.0512
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0153 0.0802 0.6109
Loa Loa (eye worm) beta-lactamase 0.0039 0.012 0.0907
Echinococcus granulosus transmembrane protease serine 3 0.0153 0.0802 0.6109
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0802 0.4512
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0067 0.0059
Schistosoma mansoni survival motor neuron protein 0.0048 0.0177 0.0935
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0033 0.011
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0196 0.104
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0239 0.1284
Brugia malayi mbt repeat family protein 0.0051 0.0196 0.1497
Brugia malayi hypothetical protein 0.0029 0.0062 0.0472
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0595 0.3325
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0118 0.0595 0.0587
Brugia malayi Cytochrome P450 family protein 0.0027 0.0047 0.0356
Loa Loa (eye worm) hypothetical protein 0.0153 0.0802 0.6128
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.0294 0.0286
Mycobacterium ulcerans hypothetical protein 0.0039 0.012 0.0249
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.012 0.0858
Mycobacterium ulcerans hypothetical protein 0.0153 0.0802 0.2556
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3004 0.5
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0196 0.1443
Onchocerca volvulus Huntingtin homolog 0.0132 0.0679 0.4923
Loa Loa (eye worm) intermediate filament protein 0.006 0.0248 0.1886
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0446 0.0438
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0067 0.0018
Schistosoma mansoni hypothetical protein 0.0036 0.0105 0.0518
Brugia malayi intermediate filament protein 0.006 0.0248 0.1897
Loa Loa (eye worm) hypothetical protein 0.0041 0.0136 0.1024
Brugia malayi mbt repeat family protein 0.0051 0.0196 0.1497
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0306 0.233
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0239 0.023
Brugia malayi Bromodomain containing protein 0.0041 0.0135 0.1032
Onchocerca volvulus Peroxidase homolog 0.0067 0.0289 0.1784
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.0294 0.2197
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.012 0.0608
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0177 0.0169
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0446 1
Schistosoma mansoni hypothetical protein 0.0172 0.0917 0.5165
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0306 0.1672
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.012 0.0907
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0081 0.0617
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0446 0.2735
Brugia malayi beta-lactamase family protein 0.0039 0.012 0.0919
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0196 0.1485
Echinococcus granulosus glycoprotein Antigen 5 0.0153 0.0802 0.6109
Echinococcus multilocularis enteropeptidase 0.0153 0.0802 0.0795
Schistosoma mansoni lamin 0.006 0.0248 0.1339
Brugia malayi Ets-domain containing protein 0.0075 0.0337 0.2576
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0248 0.1897
Brugia malayi jmjC domain containing protein 0.007 0.0306 0.234
Loa Loa (eye worm) hypothetical protein 0.0153 0.0802 0.6128
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.2198
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0196 0.1036
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3004 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1138 0.8696
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0446 0.3047
Echinococcus granulosus Mastin 0.0153 0.0802 0.6109
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0294 0.0286
Leishmania major hypothetical protein, conserved 0.0029 0.0062 0.038
Schistosoma mansoni hypothetical protein 0.0153 0.0802 0.4512
Loa Loa (eye worm) hypothetical protein 0.0046 0.0163 0.1236
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0196 0.0188
Echinococcus multilocularis musashi 0.006 0.0248 0.024
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0062 0.038
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0273 0.0265
Loa Loa (eye worm) hypothetical protein 0.0076 0.0345 0.2624
Loa Loa (eye worm) hypothetical protein 0.006 0.0248 0.1886
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0289 0.2208
Echinococcus multilocularis Mastin 0.0153 0.0802 0.0795
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0595 0.3325
Schistosoma mansoni hypothetical protein 0.0313 0.1761 1
Loa Loa (eye worm) fli-1 protein 0.0228 0.1252 0.9569
Loa Loa (eye worm) hypothetical protein 0.0132 0.0679 0.5185
Loa Loa (eye worm) hypothetical protein 0.0059 0.0239 0.1812
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0289 0.2208
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0446 1
Brugia malayi Pre-SET motif family protein 0.0209 0.1138 0.8698
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0153 0.0802 0.4512
Schistosoma mansoni peroxidasin 0.0067 0.0289 0.1573
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.012 0.1846
Schistosoma mansoni lamin 0.006 0.0248 0.1339
Loa Loa (eye worm) hypothetical protein 0.0051 0.0196 0.1485
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0196 0.104
Onchocerca volvulus 0.0039 0.012 0.0429
Loa Loa (eye worm) hypothetical protein 0.0044 0.0151 0.1141
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0033 0.0192
Toxoplasma gondii melibiase subfamily protein 0.0118 0.0595 0.1813
Loa Loa (eye worm) animal heme peroxidase 0.0067 0.0289 0.2198
Brugia malayi beta-lactamase family protein 0.0039 0.012 0.0919
Onchocerca volvulus 0.0153 0.0802 0.5913
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.2198
Echinococcus multilocularis glycoprotein Antigen 5 0.0153 0.0802 0.0795
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0802 0.4512
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0164 0.0367
Trypanosoma brucei polo-like protein kinase 0.0093 0.0446 1
Echinococcus granulosus peroxidasin 0.0067 0.0289 0.2158
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0289 0.2208
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.2198
Brugia malayi beta-lactamase 0.0039 0.012 0.0919
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.012 0.0919
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0153 0.0802 0.0795
Brugia malayi hypothetical protein 0.0067 0.0289 0.2208
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0446 0.3408
Loa Loa (eye worm) hypothetical protein 0.0039 0.012 0.0907
Echinococcus granulosus intermediate filament protein 0.006 0.0248 0.1845
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.012 0.1846
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.2198
Onchocerca volvulus 0.006 0.0248 0.1457
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0446 0.3366
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.012 0.0608
Brugia malayi Ets-domain containing protein 0.0075 0.0337 0.2576
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.0408
Schistosoma mansoni kinase 0.0047 0.0171 0.09
Onchocerca volvulus 0.0048 0.0177 0.0888
Onchocerca volvulus 0.006 0.0248 0.1457
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.2198
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0047 0.0343
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0273 0.2039
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.0359 0.1976
Mycobacterium ulcerans lipase LipD 0.0039 0.012 0.0249
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0047 0.0343
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0802 0.4512
Leishmania major hypothetical protein, conserved 0.0039 0.012 0.1846
Onchocerca volvulus Huntingtin homolog 0.0132 0.0679 0.4923
Onchocerca volvulus 0.0067 0.0289 0.1784
Brugia malayi Blistered cuticle protein 3 0.0067 0.0289 0.2208
Brugia malayi hypothetical protein 0.0132 0.0679 0.5192
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0047 0.0343
Loa Loa (eye worm) hypothetical protein 0.0132 0.0679 0.5185
Loa Loa (eye worm) hypothetical protein 0.0153 0.0802 0.6128
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0062 0.038
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.006 0.0401
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0164 0.0367
Brugia malayi Melibiase family protein 0.0079 0.0359 0.2747
Echinococcus granulosus lamin dm0 0.006 0.0248 0.1845
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0153 0.0802 0.6109
Brugia malayi Trypsin family protein 0.0153 0.0802 0.6133
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0446 1
Brugia malayi Cytochrome P450 family protein 0.0027 0.0047 0.0356
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.0359 0.1976
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0177 0.0933
Onchocerca volvulus 0.0153 0.0802 0.5913
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.1102 0.8415
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.0337 0.2566
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0105 0.0518
Loa Loa (eye worm) hypothetical protein 0.0237 0.1308 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.0802 0.6128
Loa Loa (eye worm) hypothetical protein 0.0153 0.0802 0.6128
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.012 0.0249
Schistosoma mansoni gabp alpha 0.0075 0.0337 0.1848
Onchocerca volvulus 0.0153 0.0802 0.5913
Onchocerca volvulus 0.0153 0.0802 0.5913
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0802 0.4512
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.2198
Loa Loa (eye worm) hypothetical protein 0.0029 0.0062 0.0459
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0289 0.2208
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.2198
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.0337 0.2529
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.2198
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0446 0.2735
Schistosoma mansoni intermediate filament proteins 0.006 0.0248 0.1339
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0446 0.3399
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0153 0.0802 0.4512
Onchocerca volvulus 0.0067 0.0289 0.1784
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0153 0.0802 0.4512
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.2198
Echinococcus multilocularis peroxidasin 0.0067 0.0289 0.0281
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0033 0.0025
Onchocerca volvulus 0.0237 0.1311 1
Onchocerca volvulus 0.0039 0.012 0.0429
Loa Loa (eye worm) MBCTL1 0.0059 0.0239 0.1812
Brugia malayi Trypsin family protein 0.0153 0.0802 0.6133
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.052 0.3004 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.012 0.0112
Loa Loa (eye worm) hypothetical protein 0.0039 0.012 0.0907
Loa Loa (eye worm) hypothetical protein 0.0079 0.0359 0.2737
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0289 0.2208
Echinococcus granulosus lamin 0.006 0.0248 0.1845
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0177 0.0933
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.2198
Loa Loa (eye worm) animal heme peroxidase 0.0067 0.0289 0.2198
Schistosoma mansoni hypothetical protein 0.0153 0.0802 0.4512
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0021 0.0147
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0802 0.4512
Schistosoma mansoni hypothetical protein 0.0022 0.0021 0.0039
Echinococcus multilocularis zinc finger protein 0.0021 0.0014 0.0006
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.2198
Loa Loa (eye worm) hypothetical protein 0.0064 0.0272 0.2067
Loa Loa (eye worm) hypothetical protein 0.0039 0.012 0.0907
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0239 0.1771
Schistosoma mansoni peroxidasin 0.0067 0.0289 0.1573
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.2198
Echinococcus granulosus geminin 0.0172 0.0917 0.6987
Brugia malayi Trypsin-like protease protein 5 0.0153 0.0802 0.6133
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.1102 0.1095
Giardia lamblia Kinase, PLK 0.0093 0.0446 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0446 0.2735
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0067 0.0302
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0239 0.1823
Schistosoma mansoni ets-related 0.0228 0.1252 0.7085
Loa Loa (eye worm) hypothetical protein 0.0029 0.0062 0.0458
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0446 0.2471
Onchocerca volvulus 0.0039 0.012 0.0429
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0802 0.4512
Loa Loa (eye worm) hypothetical protein 0.0067 0.0289 0.2198
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0081 0.0605
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0802 0.4512
Brugia malayi Bromodomain containing protein 0.0081 0.0372 0.2845
Brugia malayi Trypsin family protein 0.0153 0.0802 0.6133
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0196 0.104
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.3004 1
Brugia malayi PHD-finger family protein 0.0027 0.0049 0.0371
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3004 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0177 0.1356
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0306 0.2292
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.1374 1
Brugia malayi jmjC domain containing protein 0.0068 0.0294 0.2246
Brugia malayi Cytochrome P450 family protein 0.0056 0.0223 0.1706
Loa Loa (eye worm) animal heme peroxidase 0.0067 0.0289 0.2198
Onchocerca volvulus Peroxidasin homolog 0.0067 0.0289 0.1784
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0125 0.0637 0.4122
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0177 0.1299
Loa Loa (eye worm) hypothetical protein 0.0039 0.012 0.0907
Onchocerca volvulus Chorion peroxidase homolog 0.0067 0.0289 0.1784
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0196 0.0188
Echinococcus multilocularis lamin 0.006 0.0248 0.024
Brugia malayi Trypsin family protein 0.0153 0.0802 0.6133
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.012 0.0249
Mycobacterium ulcerans beta-lactamase 0.0039 0.012 0.0249
Onchocerca volvulus Peroxidasin homolog 0.0067 0.0289 0.1784
Echinococcus granulosus enteropeptidase 0.0153 0.0802 0.6109
Schistosoma mansoni cercarial elastase (S01 family) 0.0153 0.0802 0.4512
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0153 0.0802 0.4512
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.012 0.0861
Loa Loa (eye worm) trypsin family protein 0.0153 0.0802 0.6128
Onchocerca volvulus Dual oxidase homolog 0.0067 0.0289 0.1784
Onchocerca volvulus Peroxidase homolog 0.0067 0.0289 0.1784
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0294 0.1601
Onchocerca volvulus 0.0153 0.0802 0.5913
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0067 0.0302
Echinococcus multilocularis geminin 0.0172 0.0917 0.0909
Plasmodium vivax SET domain protein, putative 0.003 0.0067 0.0018
Onchocerca volvulus 0.0153 0.0802 0.5913
Loa Loa (eye worm) hypothetical protein 0.0039 0.012 0.0907
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.012 0.1846
Schistosoma mansoni hypothetical protein 0.0172 0.0917 0.5165
Trichomonas vaginalis set domain proteins, putative 0.0237 0.1311 1
Loa Loa (eye worm) animal heme peroxidase 0.0067 0.0289 0.2198
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0223 0.1695
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.012 0.0112
Brugia malayi hypothetical protein 0.0153 0.0802 0.6133

Activities

Activity type Activity value Assay description Source Reference
Log IC50 (binding) = 6.15 Inhibitory concentration against DOXP reductoisomerase ChEMBL. 15887963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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