Detailed information for compound 347740

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 355.517 | Formula: C22H33N3O
  • H donors: 1 H acceptors: 1 LogP: 3.96 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1CNC(=O)C21CCN(CC2)[C@H]1CCCC[C@H]1c1ccccc1
  • InChi: 1S/C22H33N3O/c1-2-14-25-17-23-21(26)22(25)12-15-24(16-13-22)20-11-7-6-10-19(20)18-8-4-3-5-9-18/h3-5,8-9,19-20H,2,6-7,10-17H2,1H3,(H,23,26)/t19-,20-/m0/s1
  • InChiKey: LJMDGQMIYHIQTC-PMACEKPBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus multilocularis sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus multilocularis sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus granulosus sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128673 All targets in OG5_128673
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum Sodium-dependent proline transporter, putative Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum Sodium- and chloride-dependent glycine transporter 1, putative Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum Sodium- and chloride-dependent glycine transporter 1, putative Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Get druggable targets OG5_128673 All targets in OG5_128673
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128673 All targets in OG5_128673
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128673 All targets in OG5_128673
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128673 All targets in OG5_128673
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis serotonin transporter solute carrier family 6 (neurotransmitter transporter, glycine), member 9 633 aa 616 aa 38.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0389 0.0363
Brugia malayi Carboxylesterase family protein 0.0095 0.1478 0.1455
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0043 0.0528 0.529
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0029 0.0277 0.0251
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0003
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0926 1
Onchocerca volvulus 0.0156 0.261 0.4722
Onchocerca volvulus 0.0095 0.1478 0.2315
Toxoplasma gondii P-type ATPase PMA1 0.0027 0.0243 0.2785
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0019 0.0087 0.006
Onchocerca volvulus 0.0095 0.1478 0.2315
Brugia malayi neuropeptide F receptor 0.004 0.0483 0.0458
Trypanosoma brucei calcium-transporting ATPase, putative 0.002 0.012 0.0471
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0615 0.059
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0047 0.0615 0.059
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0136 0.0653
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis thioredoxin glutathione reductase 0.0062 0.0873 0.0848
Plasmodium falciparum thioredoxin reductase 0.0062 0.0873 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0389 0.0363
Echinococcus granulosus nervana 2 0.0064 0.0923 0.0899
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0926 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0136 0.1185
Echinococcus granulosus nervana 2 0.0064 0.0923 0.0899
Schistosoma mansoni thyroid hormone receptor 0.0133 0.2177 0.2156
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.004 0.0483 0.0458
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0095 0.1478 0.3698
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.0892
Echinococcus multilocularis neuropeptide s receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0634 0.061
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0483 0.0458
Brugia malayi hypothetical protein 0.0095 0.1478 0.1455
Echinococcus multilocularis thyroid hormone receptor alpha 0.0133 0.2177 0.2156
Brugia malayi hypothetical protein 0.0156 0.261 0.259
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Echinococcus multilocularis protein cereblon 0.0292 0.5092 0.5079
Brugia malayi G-protein coupled receptor 0.004 0.0483 0.0458
Echinococcus multilocularis peroxidasin 0.0156 0.261 0.259
Onchocerca volvulus Dual oxidase homolog 0.0156 0.261 0.4722
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.056 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Toxoplasma gondii P-type ATPase4, putative 0.0043 0.0528 0.6047
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.004 0.0483 0.02
Schistosoma mansoni neuropeptide f receptor 76f 0.004 0.0483 0.0458
Echinococcus multilocularis nervana 2 0.0064 0.0923 0.0899
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) TYRA-2 protein 0.004 0.0483 0.0458
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0136 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0926 0.0902
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0064 0.0923 0.0899
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Mycobacterium leprae Probable lipase LipE 0.0035 0.0389 1
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0483 0.0458
Brugia malayi Serotonin receptor 0.004 0.0483 0.0458
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0923 0.0899
Echinococcus granulosus tachykinin peptides receptor 99D 0.034 0.5981 0.597
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0095 0.1478 0.1455
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0021 0.0136 0.0146
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0483 0.0458
Mycobacterium ulcerans lipase LipD 0.0035 0.0389 0.2207
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Trichomonas vaginalis glutathione reductase, putative 0.0021 0.0136 0.0395
Trypanosoma cruzi calcium-transporting ATPase, putative 0.002 0.012 0.1013
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0483 0.0458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0043 0.0528 0.0502
Onchocerca volvulus Peroxidase homolog 0.0156 0.261 0.4722
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) carboxylesterase 0.056 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Trichomonas vaginalis esterase, putative 0.0035 0.0389 0.2207
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0127 0.033
Plasmodium vivax amine transporter, putative 0.0047 0.0615 0.704
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni biogenic amine receptor 0.004 0.0483 0.0458
Echinococcus granulosus g protein coupled receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0035 0.0389 0.0363
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0034 0.0371 0.0346
Echinococcus multilocularis g-protein coupled receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Trichomonas vaginalis cation-transporting ATPase, putative 0.0043 0.0528 0.3199
Brugia malayi sulfakinin receptor protein 0.0294 0.5132 0.5119
Echinococcus granulosus neuroligin 0.0095 0.1478 0.1455
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.261 0.259
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0926 0.0902
Brugia malayi hypothetical protein 0.0292 0.5092 0.5079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.1185
Loa Loa (eye worm) hypothetical protein 0.0035 0.0389 0.0363
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Schistosoma mansoni hypothetical protein 0.004 0.0483 0.0458
Brugia malayi Animal haem peroxidase family protein 0.0156 0.261 0.259
Onchocerca volvulus 0.004 0.0483 0.02
Echinococcus granulosus serotonin transporter 0.0098 0.1539 0.1516
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0095 0.1478 0.1455
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis sex peptide receptor 0.004 0.0483 0.0458
Brugia malayi Animal haem peroxidase family protein 0.0156 0.261 0.259
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0029 0.0277 0.0251
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0034 0.0371 0.0346
Echinococcus multilocularis allatostatin A receptor 0.004 0.0483 0.0458
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0046 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0483 0.0458
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0127 0.01
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0483 0.0458
Echinococcus multilocularis sodium and chloride dependent glycine 0.0201 0.3435 0.3417
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0021 0.0136 0.1556
Echinococcus multilocularis dro:myosuppressin receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.056 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0389 0.0363
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.004 0.0483 0.0458
Echinococcus granulosus acetylcholinesterase 0.056 1 1
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0615 0.704
Schistosoma mansoni amine GPCR 0.004 0.0483 0.0458
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0081 0.0054
Loa Loa (eye worm) carboxylesterase 0.0095 0.1478 0.1455
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1996 0.1975
Schistosoma mansoni neuropeptide receptor 0.004 0.0483 0.0458
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0483 0.0458
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0047 0.0615 0.059
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0923 0.0899
Onchocerca volvulus 0.004 0.0483 0.02
Onchocerca volvulus 0.0047 0.0615 0.0481
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0483 0.0458
Brugia malayi Dopamine receptor 0.004 0.0483 0.0458
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0615 0.059
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0081 0.0891
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0034 0.0371 0.6504
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0923 0.0899
Loa Loa (eye worm) E1-E2 ATPase 0.0027 0.0243 0.0217
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0389 0.0816
Echinococcus multilocularis alpha 1A adrenergic receptor 0.004 0.0483 0.0458
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0019 0.0087 0.0012
Echinococcus granulosus neuropeptide s receptor 0.004 0.0483 0.0458
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0389 0.2207
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0265 0.4597 0.4582
Trichomonas vaginalis cation-transporting ATPase, putative 0.0043 0.0528 0.3199
Echinococcus multilocularis g protein coupled receptor 0.004 0.0483 0.0458
Schistosoma mansoni peroxidasin 0.0156 0.261 0.259
Brugia malayi Melatonin receptor type 1A 0.004 0.0483 0.0458
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0483 0.0458
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0371 0.2081
Trypanosoma cruzi P-type H+-ATPase, putative 0.0027 0.0243 0.2382
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0064 0.0923 0.0899
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0483 0.0458
Echinococcus granulosus protein cereblon 0.0292 0.5092 0.5079
Onchocerca volvulus Peroxidasin homolog 0.0156 0.261 0.4722
Schistosoma mansoni ap endonuclease 0.0018 0.0081 0.0054
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0043 0.0528 0.529
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0029 0.0277 0.0519
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.3199
Schistosoma mansoni amine GPCR 0.004 0.0483 0.0458
Brugia malayi AKH receptor 0.004 0.0483 0.0458
Schistosoma mansoni hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0047 0.0615 0.059
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0021 0.0136 0.011
Schistosoma mansoni hypothetical protein 0.0334 0.5868 0.5857
Mycobacterium tuberculosis Probable oxidoreductase 0.0021 0.0136 0.0146
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.004 0.0483 0.0458
Brugia malayi gonadotropin-releasing hormone receptor 2 0.004 0.0483 0.0458
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0032 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0043 0.0528 0.529
Echinococcus granulosus calcium transporting atpase 0.0034 0.0371 0.0346
Onchocerca volvulus 0.0095 0.1478 0.2315
Mycobacterium tuberculosis Conserved protein 0.0035 0.0389 0.0816
Schistosoma mansoni acetylcholinesterase 0.0095 0.1478 0.1455
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.261 0.259
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0043 0.0528 0.6047
Brugia malayi calcium ATPase 0.0016 0.003 0.0003
Echinococcus granulosus neuropeptide receptor 0.004 0.0483 0.0458
Schistosoma mansoni hypothetical protein 0.0334 0.5868 0.5857
Brugia malayi G protein-coupled receptor 0.004 0.0483 0.0458
Echinococcus granulosus 7tm_1 domain containing protein 0.004 0.0483 0.0458
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0043 0.0528 0.3199
Onchocerca volvulus 0.0095 0.1478 0.2315
Echinococcus granulosus geminin 0.0334 0.5868 0.5857
Echinococcus multilocularis tachykinin peptides receptor 99D 0.034 0.5981 0.597
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0615 0.705
Plasmodium vivax thioredoxin reductase, putative 0.0062 0.0873 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0615 0.059
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0483 0.0458
Brugia malayi neuropeptide F receptor 0.004 0.0483 0.0458
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0483 0.0458
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0021 0.0136 0.0395
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0483 0.0458
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0021 0.0136 0.011
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0021 0.0136 0.0395
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Loa Loa (eye worm) acetylcholinesterase 1 0.056 1 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Onchocerca volvulus Neuropeptide F receptor homolog 0.004 0.0483 0.02
Giardia lamblia NADH oxidase lateral transfer candidate 0.0021 0.0136 0.1235
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.004 0.0483 0.0458
Echinococcus granulosus peptide allatostatin:somatostatin 0.004 0.0483 0.0458
Onchocerca volvulus Peroxidase homolog 0.0156 0.261 0.4722
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0353 0.0327
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.3199
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0043 0.0528 1
Onchocerca volvulus 0.004 0.0483 0.02
Brugia malayi Animal haem peroxidase family protein 0.0156 0.261 0.259
Leishmania major calcium-transporting ATPase, putative 0.0034 0.0371 0.3441
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0034 0.0371 0.0346
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.002 0.012 0.0094
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0483 0.0458
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0029 0.0277 0.5563
Echinococcus multilocularis neuropeptide receptor A26 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0389 0.0363
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.3859 1
Echinococcus multilocularis g protein coupled receptor 0.004 0.0483 0.0458
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0483 0.0458
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0047 0.0615 1
Schistosoma mansoni hypothetical protein 0.0033 0.0353 0.0327
Echinococcus granulosus g-protein coupled receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0095 0.1478 0.1455
Loa Loa (eye worm) norepinephrine transporter 0.0098 0.1539 0.1516
Loa Loa (eye worm) hypothetical protein 0.0095 0.1478 0.1455
Brugia malayi hypothetical protein 0.0119 0.1922 0.1901
Onchocerca volvulus 0.004 0.0483 0.02
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0081 0.0054
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0043 0.0528 0.529
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.3199
Brugia malayi Serotonin/octopamine receptor family protein 7 0.004 0.0483 0.0458
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.004 0.0483 0.0458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.1185
Onchocerca volvulus 0.004 0.0483 0.02
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0389 0.0363
Onchocerca volvulus 0.004 0.0483 0.02
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0043 0.0528 0.3199
Brugia malayi hypothetical protein 0.0047 0.0615 0.059
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0483 0.0458
Echinococcus granulosus neuropeptide receptor A26 0.004 0.0483 0.0458
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0047 0.0615 0.059
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0389 0.401
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0389 0.0363
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0389 0.0816
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0483 0.0458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.1185
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0389 0.0816
Schistosoma mansoni myosin xvIII 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Entamoeba histolytica hypothetical protein, conserved 0.0292 0.5092 1
Leishmania major P-type H -ATPase, putative 0.0027 0.0243 0.1922
Loa Loa (eye worm) calcium ATPase 0.0024 0.0186 0.016
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.004 0.0483 0.0458
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0615 0.059
Echinococcus multilocularis carboxylesterase 5A 0.056 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0023
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0428 0.0403
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0043 0.0528 0.0502
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0561 0.0536
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0043 0.0528 0.529
Loa Loa (eye worm) hypothetical protein 0.0049 0.0634 0.061
Echinococcus granulosus orexin receptor type 2 0.004 0.0483 0.0458
Brugia malayi Carboxylesterase family protein 0.0095 0.1478 0.1455
Toxoplasma gondii NADPH-glutathione reductase 0.0021 0.0136 0.1556
Brugia malayi Serotonin receptor 0.004 0.0483 0.0458
Mycobacterium tuberculosis Conserved protein 0.0035 0.0389 0.0816
Loa Loa (eye worm) hypothetical protein 0.0047 0.0615 0.059
Onchocerca volvulus 0.004 0.0483 0.02
Toxoplasma gondii hypothetical protein 0.0047 0.0615 0.705
Onchocerca volvulus 0.004 0.0483 0.02
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0923 0.0899
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0095 0.1478 0.3698
Loa Loa (eye worm) hypothetical protein 0.0043 0.0528 0.0502
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.0892
Schistosoma mansoni histamine h1 receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0292 0.5092 0.5079
Brugia malayi beta-lactamase family protein 0.0035 0.0389 0.0363
Brugia malayi Animal haem peroxidase family protein 0.0156 0.261 0.259
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0034 0.0371 0.3814
Mycobacterium tuberculosis Conserved protein 0.0035 0.0389 0.0816
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0389 0.0816
Echinococcus multilocularis acetylcholinesterase 0.056 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Plasmodium vivax glutathione reductase, putative 0.0062 0.0873 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0021 0.0136 0.0653
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0483 0.0458
Onchocerca volvulus Peroxidasin homolog 0.0156 0.261 0.4722
Mycobacterium tuberculosis Carboxylesterase LipT 0.0095 0.1478 0.3698
Onchocerca volvulus 0.004 0.0483 0.02
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0095 0.1478 0.1455
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0201 0.3435 0.3417
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0389 0.0816
Treponema pallidum NADH oxidase 0.0021 0.0136 0.0378
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0095 0.1478 0.1455
Schistosoma mansoni ATPase 0.0043 0.0528 0.0502
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.0873 0.9408
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0483 0.0458
Echinococcus multilocularis sodium and chloride dependent glycine 0.0201 0.3435 0.3417
Loa Loa (eye worm) hypothetical protein 0.0047 0.0615 0.059
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0615 0.705
Brugia malayi putative neuropeptide receptor 0.004 0.0483 0.0458
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0389 1
Onchocerca volvulus Chorion peroxidase homolog 0.0156 0.261 0.4722
Loa Loa (eye worm) hypothetical protein 0.0064 0.0923 0.0899
Schistosoma mansoni neuropeptide receptor 0.004 0.0483 0.0458
Echinococcus multilocularis geminin 0.0334 0.5868 0.5857
Echinococcus multilocularis acetylcholinesterase 0.056 1 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1996 0.1975
Loa Loa (eye worm) hypothetical protein 0.0098 0.1539 0.1516
Plasmodium falciparum glutathione reductase 0.0021 0.0136 0.07
Brugia malayi ORL1-like opioid receptor 0.004 0.0483 0.0458
Schistosoma mansoni transmemberane protein 0.0064 0.0923 0.0899
Leishmania major calcium-translocating P-type ATPase 0.0043 0.0528 0.529
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.0653
Loa Loa (eye worm) hypothetical protein 0.0047 0.0615 0.059
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Schistosoma mansoni sodium/chloride dependent transporter 0.0201 0.3435 0.3417
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Echinococcus granulosus hypothetical protein 0.004 0.0483 0.0458
Plasmodium falciparum glutathione reductase 0.0062 0.0873 1
Brugia malayi Carboxylesterase family protein 0.0095 0.1478 0.1455
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0561 0.0536
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0923 0.0899
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.004 0.0483 0.0458
Brugia malayi Thioredoxin reductase 0.0062 0.0873 0.0848
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0483 0.0458
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0615 0.059
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0483 0.0458
Echinococcus multilocularis nervana 2 0.0064 0.0923 0.0899
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0561 0.0536
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0483 0.0458
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.0892
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0483 0.0458
Brugia malayi beta-lactamase 0.0035 0.0389 0.0363
Echinococcus multilocularis serotonin receptor 0.004 0.0483 0.0458
Echinococcus multilocularis neuropeptide receptor 0.004 0.0483 0.0458
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0043 0.0528 0.3199
Loa Loa (eye worm) hypothetical protein 0.0035 0.0389 0.0363
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0136 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.004 0.0483 0.0458
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0483 0.0458
Schistosoma mansoni peptide (allatostatin)-like receptor 0.004 0.0483 0.0458
Leishmania major hypothetical protein, conserved 0.0035 0.0389 0.3649
Plasmodium vivax P-type ATPase4, putative 0.0043 0.0528 0.6033
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Schistosoma mansoni opsin-like receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Onchocerca volvulus 0.004 0.0483 0.02
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0081 0.0003
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Plasmodium falciparum transporter, putative 0.0047 0.0615 0.6751
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus granulosus g protein coupled receptor 0.004 0.0483 0.0458
Schistosoma mansoni thyroid hormone receptor 0.0133 0.2177 0.2156
Mycobacterium ulcerans carboxylesterase, LipT 0.0095 0.1478 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0095 0.1478 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0615 0.059
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0389 0.2207
Echinococcus granulosus sodium and chloride dependent glycine 0.0201 0.3435 0.3417
Loa Loa (eye worm) hypothetical protein 0.0098 0.1539 0.1516
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0021 0.0136 0.0653
Onchocerca volvulus 0.0156 0.261 0.4722
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.1185
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.261 0.259
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0201 0.3435 0.3417
Echinococcus multilocularis para nitrobenzyl esterase 0.0095 0.1478 0.1455
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0021 0.0136 0.07
Echinococcus granulosus neuropeptide receptor 0.004 0.0483 0.0458
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.3199
Schistosoma mansoni amine GPCR 0.004 0.0483 0.0458
Onchocerca volvulus 0.0043 0.0528 0.0295
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0389 0.2207
Echinococcus granulosus nervana 2 0.0064 0.0923 0.0899
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0034 0.0371 0.0346
Echinococcus multilocularis nervana 2 0.0064 0.0923 0.0899
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0034 0.0371 0.3441
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0021 0.0136 0.0653
Schistosoma mansoni hypothetical protein 0.0292 0.5092 0.5079
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0634 0.061
Treponema pallidum sodium- and chloride- dependent transporter 0.0098 0.1539 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis somatostatin receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) RecQ helicase 0.0021 0.0127 0.01
Echinococcus granulosus BC026374 protein S09 family 0.0095 0.1478 0.1455
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0127 0.033
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis g protein coupled receptor 0.004 0.0483 0.0458
Trichomonas vaginalis cation-transporting ATPase, putative 0.0027 0.0243 0.1163
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0081 0.0054
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0098 0.1539 0.1516
Trypanosoma brucei P-type H+-ATPase, putative 0.0027 0.0243 0.1922
Onchocerca volvulus 0.004 0.0483 0.02
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Trypanosoma cruzi P-type H+-ATPase, putative 0.0027 0.0243 0.2382
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.1185
Onchocerca volvulus 0.004 0.0483 0.02
Brugia malayi RE15519p 0.004 0.0483 0.0458
Onchocerca volvulus 0.004 0.0483 0.02
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Brugia malayi beta-lactamase family protein 0.0035 0.0389 0.0363
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0021 0.0136 0.011
Echinococcus multilocularis biogenic amine (5HT) receptor 0.004 0.0483 0.0458
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0047 0.0615 0.059
Brugia malayi Tachykinin-like peptides receptor 99D 0.004 0.0483 0.0458
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0561 0.0536
Echinococcus granulosus thioredoxin glutathione reductase 0.0062 0.0873 0.0848
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) carboxylesterase 0.0095 0.1478 0.1455
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0043 0.0528 0.0502
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0389 0.401
Brugia malayi G protein-coupled receptor F59B2.13 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0064 0.0923 0.0899
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0389 0.2207
Loa Loa (eye worm) beta-lactamase 0.0035 0.0389 0.0363
Brugia malayi follicle stimulating hormone receptor 0.0265 0.4597 0.4582
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0032 0.0006
Echinococcus multilocularis nervana 2 0.0064 0.0923 0.0899
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0064 0.0923 0.0899
Echinococcus granulosus serotonin receptor 0.004 0.0483 0.0458
Trypanosoma cruzi P-type H+-ATPase, putative 0.0019 0.0087 0.0638
Schistosoma mansoni sodium/chloride dependent transporter 0.0201 0.3435 0.3417
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0019 0.0087 0.006
Echinococcus granulosus Na:K ATPase alpha subunit 0.0034 0.0371 0.0346
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.004 0.0483 0.0458
Mycobacterium ulcerans beta-lactamase 0.0035 0.0389 0.2207
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0043 0.0528 0.0502
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Onchocerca volvulus 0.0064 0.0923 0.1135
Loa Loa (eye worm) glutathione reductase 0.0062 0.0873 0.0848
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis neuropeptide receptor 0.004 0.0483 0.0458
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0024 0.0186 0.021
Echinococcus granulosus para nitrobenzyl esterase 0.0095 0.1478 0.1455
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0034 0.0371 0.0346
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0615 0.059
Schistosoma mansoni biogenic amine receptor 0.004 0.0483 0.0458
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0389 0.2207
Schistosoma mansoni gliotactin 0.0095 0.1478 0.1455
Leishmania major P-type ATPase, putative 0.0034 0.0371 0.3441
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0483 0.0458
Onchocerca volvulus 0.0047 0.0615 0.0481
Echinococcus granulosus bloom syndrome protein 0.0021 0.0127 0.01
Brugia malayi Na,K-ATPase alpha subunit 0.0043 0.0528 0.0502
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0034 0.0371 0.6504
Loa Loa (eye worm) hypothetical protein 0.031 0.5419 0.5406
Echinococcus granulosus neuropeptide FF receptor 2 0.004 0.0483 0.0458
Trichomonas vaginalis cation-transporting ATPase, putative 0.0043 0.0528 0.3199
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0064 0.0923 0.0899
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0024 0.0186 0.016
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0389 0.3649
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0615 0.059
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Onchocerca volvulus 0.004 0.0483 0.02
Brugia malayi GnHR receptor homolog 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.002 0.012 0.0094
Loa Loa (eye worm) hypothetical protein 0.0035 0.0389 0.0363
Schistosoma mansoni amine GPCR 0.004 0.0483 0.0458
Echinococcus multilocularis fmrfamide receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus granulosus G protein coupled receptor 139 0.004 0.0483 0.0458
Echinococcus multilocularis calcium transporting atpase 0.0034 0.0371 0.0346
Echinococcus granulosus acetylcholinesterase 0.056 1 1
Schistosoma mansoni ap endonuclease 0.0018 0.0081 0.0054
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0095 0.1478 0.1455
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni opsin-like receptor 0.004 0.0483 0.0458
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0926 0.0902
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0034 0.0371 0.0346
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0483 0.0458
Trypanosoma brucei P-type H+-ATPase, putative 0.0027 0.0243 0.1922
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0043 0.0528 0.0502
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0615 0.059
Echinococcus multilocularis orexin receptor type 2 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Plasmodium falciparum thioredoxin reductase 0.0021 0.0136 0.07
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0081 0.0569
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0043 0.0528 0.5558
Onchocerca volvulus 0.004 0.0483 0.02
Schistosoma mansoni hypothetical protein 0.004 0.0483 0.0458
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0021 0.0136 0.0146
Echinococcus granulosus nervana 2 0.0064 0.0923 0.0899
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Echinococcus granulosus peroxidasin 0.0156 0.261 0.259
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Onchocerca volvulus 0.0064 0.0923 0.1135
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0043 0.0528 0.5558
Echinococcus granulosus somatostatin receptor 0.004 0.0483 0.0458
Brugia malayi Blistered cuticle protein 3 0.0156 0.261 0.259
Schistosoma mansoni adenoreceptor 0.004 0.0483 0.0458
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0389 0.0816
Echinococcus multilocularis neuroligin 0.0095 0.1478 0.1455
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0561 0.0536
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0043 0.0528 0.6047
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0081 0.0054
Onchocerca volvulus Protein cereblon homolog 0.0292 0.5092 1
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0043 0.0528 0.0502
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0064 0.0923 0.0899
Brugia malayi Dopamine receptor protein 1 0.004 0.0483 0.0458
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0019 0.0087 0.0638
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0024 0.0186 0.021
Onchocerca volvulus 0.0156 0.261 0.4722
Loa Loa (eye worm) hypothetical protein 0.0035 0.0389 0.0363
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0021 0.0136 0.011
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0136 0.1185
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0483 0.0458
Brugia malayi Peroxidasin 0.0156 0.261 0.259
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0926 0.0902
Brugia malayi calcium ATPase 0.0019 0.0087 0.006
Echinococcus granulosus thyrotropin releasing hormone receptor 0.004 0.0483 0.0458
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0483 0.0458
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.002 0.012 0.0094
Loa Loa (eye worm) hypothetical protein 0.0095 0.1478 0.1455
Echinococcus multilocularis serotonin transporter 0.0098 0.1539 0.1516
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0081 0.0569
Echinococcus multilocularis BC026374 protein (S09 family) 0.0095 0.1478 0.1455
Loa Loa (eye worm) hypothetical protein 0.0033 0.0353 0.0327
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0062 0.0873 0.2096
Brugia malayi Animal haem peroxidase family protein 0.0156 0.261 0.259
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0136 0.1185
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.004 0.0483 0.0458
Leishmania major calcium motive p-type ATPase, putative 0.0034 0.0371 0.3441
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0019 0.0087 0.0638
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0095 0.1478 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0087 0.006
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0034 0.0371 0.0346
Plasmodium falciparum calcium-transporting ATPase 0.0034 0.0371 0.3673
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0926 0.1686
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0043 0.0528 0.0502
Echinococcus granulosus alpha 1A adrenergic receptor 0.004 0.0483 0.0458
Echinococcus multilocularis fmrfamide receptor 0.004 0.0483 0.0458
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0483 0.0458
Mycobacterium ulcerans hypothetical protein 0.0035 0.0389 0.2207
Toxoplasma gondii hypothetical protein 0.0047 0.0615 0.705
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0098 0.1539 0.1516
Brugia malayi Dopamine receptor protein 2 0.004 0.0483 0.0458
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0389 0.0363
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0127 0.01
Brugia malayi Carboxylesterase family protein 0.056 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.0653
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.1185
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0034 0.0371 0.3814
Loa Loa (eye worm) hypothetical protein 0.0047 0.0615 0.059
Trypanosoma brucei trypanothione reductase 0.0062 0.0873 0.9372
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Schistosoma mansoni alpha-1 adrenergic receptor 0.004 0.0483 0.0458
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0043 0.0528 0.5646
Loa Loa (eye worm) melatonin receptor type 1A 0.004 0.0483 0.0458
Schistosoma mansoni growth hormone secretagogue receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.004 0.0483 0.0458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0019 0.0087 0.0994
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0615 0.059
Loa Loa (eye worm) solute carrier family 6 member 4 0.0098 0.1539 0.1516
Onchocerca volvulus 0.004 0.0483 0.02
Schistosoma mansoni amine GPCR 0.004 0.0483 0.0458
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.056 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.261 0.259
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.004 0.0483 0.0458
Trypanosoma brucei calcium-translocating P-type ATPase 0.0034 0.0371 0.3441
Echinococcus granulosus sex peptide receptor 0.004 0.0483 0.0458
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0064 0.0923 0.0899
Loa Loa (eye worm) blistered cuticle protein 3 0.0156 0.261 0.259
Loa Loa (eye worm) hypothetical protein 0.0201 0.3435 0.3417
Echinococcus granulosus carboxylesterase 5A 0.056 1 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0615 0.059
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.3199
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0034 0.0371 0.0346
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.004 0.0483 0.0458
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0615 0.705
Schistosoma mansoni peroxidasin 0.0156 0.261 0.259
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0043 0.0528 0.5558
Loa Loa (eye worm) hypothetical protein 0.0201 0.3435 0.3417
Loa Loa (eye worm) hypothetical protein 0.0043 0.0528 0.0502
Loa Loa (eye worm) hypothetical protein 0.0098 0.1539 0.1516
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0034 0.0371 0.0346
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis G protein coupled receptor 139 0.004 0.0483 0.0458
Onchocerca volvulus 0.0047 0.0615 0.0481
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0389 0.0816
Schistosoma mansoni opsin-like receptor 0.004 0.0483 0.0458
Schistosoma mansoni neuropeptide receptor 0.004 0.0483 0.0458
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0389 0.2207
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.004 0.0483 0.0458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Onchocerca volvulus 0.0098 0.1539 0.2445
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.004 0.0483 0.0458
Brugia malayi G-protein coupled receptor 0.004 0.0483 0.0458
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0095 0.1478 0.1455
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.004 0.0483 0.0458
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni hypothetical protein 0.0123 0.1996 0.1975
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0021 0.0136 0.0653
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0483 0.0458
Echinococcus granulosus sodium and chloride dependent glycine 0.0201 0.3435 0.3417
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0021 0.0136 0.1526
Schistosoma mansoni ATPase 0.0043 0.0528 0.0502
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0634 0.061
Brugia malayi larval opioid receptor 0.004 0.0483 0.0458
Brugia malayi E1-E2 ATPase family protein 0.0027 0.0243 0.0217
Leishmania major P-type H -ATPase, putative 0.0027 0.0243 0.1922
Onchocerca volvulus 0.0095 0.1478 0.2315
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0043 0.0528 0.0502
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0483 0.0458
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0034 0.0371 0.0346
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0483 0.0458
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Trichomonas vaginalis mercuric reductase, putative 0.0021 0.0136 0.0395
Toxoplasma gondii exonuclease III APE 0.0018 0.0081 0.0923
Brugia malayi Carboxylesterase family protein 0.0095 0.1478 0.1455
Echinococcus granulosus dro:myosuppressin receptor 0.004 0.0483 0.0458
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0043 0.0528 0.0892
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0561 0.0536
Schistosoma mansoni sodium-dependent amino acid transporter 0.0047 0.0615 0.059
Brugia malayi Membrane calcium atpase protein 3 0.0034 0.0371 0.0346
Schistosoma mansoni biogenic amine receptor 0.004 0.0483 0.0458
Plasmodium vivax calcium-transporting ATPase, putative 0.0043 0.0528 0.6033
Schistosoma mansoni BC026374 protein (S09 family) 0.0095 0.1478 0.1455
Loa Loa (eye worm) hypothetical protein 0.0095 0.1478 0.1455
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0483 0.0458
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0029 0.0277 0.1403
Toxoplasma gondii ABC1 family protein 0.0035 0.0389 0.4457
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0034 0.0371 0.4256
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0047 0.0615 0.059
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0615 0.059
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0923 0.0899
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0389 0.2207
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0095 0.1478 0.1455
Brugia malayi glutathione reductase 0.0062 0.0873 0.0848
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.004 0.0483 0.0458
Schistosoma mansoni neuroligin 3 (S09 family) 0.0095 0.1478 0.1455
Echinococcus multilocularis neuropeptide FF receptor 2 0.004 0.0483 0.0458
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0483 0.0458
Brugia malayi hypothetical protein 0.0294 0.5132 0.5119
Schistosoma mansoni neuropeptide receptor 0.004 0.0483 0.0458
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Leishmania major trypanothione reductase 0.0062 0.0873 0.9372
Loa Loa (eye worm) thioredoxin reductase 0.0062 0.0873 0.0848
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0021 0.0136 0.1526
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.004 0.0483 0.0458
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0389 0.4438
Onchocerca volvulus 0.004 0.0483 0.02
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0021 0.0136 0.0395
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0021 0.0136 0.0146
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Brugia malayi putative neuropeptide receptor NPR1 0.004 0.0483 0.0458
Echinococcus granulosus allatostatin A receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0047 0.0615 0.059
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0926 0.0902
Loa Loa (eye worm) serotonin transporter b 0.0098 0.1539 0.1516
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0136 0.0653
Schistosoma mansoni sodium/chloride dependent transporter 0.0098 0.1539 0.1516
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0561 0.0536
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0615 0.059
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0034 0.0371 0.0346
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0561 0.0536
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0021 0.0136 0.07
Toxoplasma gondii thioredoxin reductase 0.0062 0.0873 1
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0483 0.0458
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0926 1
Loa Loa (eye worm) hypothetical protein 0.0294 0.5132 0.5119
Echinococcus granulosus 7TM GPCR rhodopsin 0.004 0.0483 0.0458
Echinococcus multilocularis serotonin receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0095 0.1478 0.1455
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0483 0.0458
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0561 0.0536
Schistosoma mansoni hypothetical protein 0.004 0.0483 0.0458
Echinococcus granulosus fmrfamide receptor 0.004 0.0483 0.0458
Plasmodium falciparum amino acid transporter, putative 0.0047 0.0615 0.6751
Echinococcus granulosus g protein coupled receptor 0.004 0.0483 0.0458
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0034 0.0371 0.0346
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0926 1
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0428 0.0403

Activities

Activity type Activity value Assay description Source Reference
CL (ADMET) = 10 uL/min.mg Clearance in mouse microsomes ChEMBL. 16246561
CL (ADMET) = 10 uL/min.mg Clearance in mouse microsomes ChEMBL. 16246561
CL (ADMET) = 25 uL/min.mg Clearance in human microsomes ChEMBL. 16246561
EC50 (binding) = 0.45 uM Displacement of [3H]glycine from human GlyT1 by radiometric assay ChEMBL. 16246561
EC50 (functional) = 0.45 uM Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNA ChEMBL. 16246557
EC50 (binding) = 0.45 uM Displacement of [3H]glycine from human GlyT1 by radiometric assay ChEMBL. 16246561
EC50 (functional) = 0.45 uM Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNA ChEMBL. 16246557
EC50 (functional) > 100 uM Inhibition of [3H]glycine uptake in cells transfected with human GlyT2 cDNA ChEMBL. 16246557
EC50 (functional) > 100 uM Inhibition of [3H]glycine uptake in cells transfected with human GlyT2 cDNA ChEMBL. 16246557
Ratio EC50 (functional) > 222 Selectivity for human GlyT2 over human GlyT1 ChEMBL. 16246557

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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