Detailed information for compound 347847

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 423.634 | Formula: C27H41N3O
  • H donors: 1 H acceptors: 1 LogP: 6.16 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NCN(C21CCN(CC2)[C@H]1CCCC[C@H]1c1ccccc1)CCC1CCCCC1
  • InChi: 1S/C27H41N3O/c31-26-27(30(21-28-26)18-15-22-9-3-1-4-10-22)16-19-29(20-17-27)25-14-8-7-13-24(25)23-11-5-2-6-12-23/h2,5-6,11-12,22,24-25H,1,3-4,7-10,13-21H2,(H,28,31)/t24-,25-/m0/s1
  • InChiKey: VINKEDWNIQKGKA-DQEYMECFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium- and chloride-dependent glycine transporter 1, putative Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum Sodium- and chloride-dependent glycine transporter 1, putative Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Get druggable targets OG5_128673 All targets in OG5_128673
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128673 All targets in OG5_128673
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128673 All targets in OG5_128673
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus granulosus sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus multilocularis sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus multilocularis sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus granulosus sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum Sodium-dependent proline transporter, putative Get druggable targets OG5_128673 All targets in OG5_128673
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis serotonin transporter solute carrier family 6 (neurotransmitter transporter, glycine), member 9 633 aa 616 aa 38.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus sodium and chloride dependent glycine 0.0201 0.3435 0.3417
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni hypothetical protein 0.0123 0.1996 0.1975
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0021 0.0136 0.0653
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0483 0.0458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0021 0.0136 0.1526
Schistosoma mansoni ATPase 0.0043 0.0528 0.0502
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0095 0.1478 0.1455
Brugia malayi G-protein coupled receptor 0.004 0.0483 0.0458
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.004 0.0483 0.0458
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0034 0.0371 0.0346
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0483 0.0458
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0483 0.0458
Leishmania major P-type H -ATPase, putative 0.0027 0.0243 0.1922
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0634 0.061
Brugia malayi E1-E2 ATPase family protein 0.0027 0.0243 0.0217
Brugia malayi larval opioid receptor 0.004 0.0483 0.0458
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0043 0.0528 0.0502
Onchocerca volvulus 0.0095 0.1478 0.2315
Loa Loa (eye worm) hypothetical protein 0.0095 0.1478 0.1455
Schistosoma mansoni biogenic amine receptor 0.004 0.0483 0.0458
Schistosoma mansoni BC026374 protein (S09 family) 0.0095 0.1478 0.1455
Plasmodium vivax calcium-transporting ATPase, putative 0.0043 0.0528 0.6033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0561 0.0536
Trichomonas vaginalis mercuric reductase, putative 0.0021 0.0136 0.0395
Toxoplasma gondii exonuclease III APE 0.0018 0.0081 0.0923
Echinococcus granulosus dro:myosuppressin receptor 0.004 0.0483 0.0458
Brugia malayi Carboxylesterase family protein 0.0095 0.1478 0.1455
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0043 0.0528 0.0892
Brugia malayi Membrane calcium atpase protein 3 0.0034 0.0371 0.0346
Schistosoma mansoni sodium-dependent amino acid transporter 0.0047 0.0615 0.059
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0923 0.0899
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0615 0.059
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0389 0.2207
Loa Loa (eye worm) hypothetical protein 0.0095 0.1478 0.1455
Brugia malayi glutathione reductase 0.0062 0.0873 0.0848
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.004 0.0483 0.0458
Schistosoma mansoni neuroligin 3 (S09 family) 0.0095 0.1478 0.1455
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0029 0.0277 0.1403
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0483 0.0458
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0047 0.0615 0.059
Toxoplasma gondii ABC1 family protein 0.0035 0.0389 0.4457
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0034 0.0371 0.4256
Loa Loa (eye worm) thioredoxin reductase 0.0062 0.0873 0.0848
Leishmania major trypanothione reductase 0.0062 0.0873 0.9372
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0389 0.4438
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.004 0.0483 0.0458
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0021 0.0136 0.1526
Brugia malayi hypothetical protein 0.0294 0.5132 0.5119
Schistosoma mansoni neuropeptide receptor 0.004 0.0483 0.0458
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0483 0.0458
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0483 0.0458
Echinococcus multilocularis neuropeptide FF receptor 2 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.004 0.0483 0.0458
Echinococcus granulosus allatostatin A receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0047 0.0615 0.059
Loa Loa (eye worm) serotonin transporter b 0.0098 0.1539 0.1516
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0926 0.0902
Brugia malayi putative neuropeptide receptor NPR1 0.004 0.0483 0.0458
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0136 0.0653
Onchocerca volvulus 0.004 0.0483 0.02
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0021 0.0136 0.0395
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0021 0.0136 0.0146
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0095 0.1478 0.1455
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0561 0.0536
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0561 0.0536
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0034 0.0371 0.0346
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0021 0.0136 0.07
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0615 0.059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0561 0.0536
Schistosoma mansoni sodium/chloride dependent transporter 0.0098 0.1539 0.1516
Loa Loa (eye worm) hypothetical protein 0.0294 0.5132 0.5119
Echinococcus granulosus 7TM GPCR rhodopsin 0.004 0.0483 0.0458
Echinococcus multilocularis serotonin receptor 0.004 0.0483 0.0458
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0926 1
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0483 0.0458
Toxoplasma gondii thioredoxin reductase 0.0062 0.0873 1
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0428 0.0403
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0926 1
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0034 0.0371 0.0346
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Plasmodium falciparum amino acid transporter, putative 0.0047 0.0615 0.6751
Echinococcus granulosus fmrfamide receptor 0.004 0.0483 0.0458
Schistosoma mansoni hypothetical protein 0.004 0.0483 0.0458
Echinococcus granulosus g protein coupled receptor 0.004 0.0483 0.0458
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0483 0.0458
Echinococcus granulosus thyrotropin releasing hormone receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0095 0.1478 0.1455
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.002 0.012 0.0094
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0021 0.0136 0.011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0389 0.0363
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0136 0.1185
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0483 0.0458
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0926 0.0902
Brugia malayi calcium ATPase 0.0019 0.0087 0.006
Brugia malayi Peroxidasin 0.0156 0.261 0.259
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.004 0.0483 0.0458
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0062 0.0873 0.2096
Brugia malayi Animal haem peroxidase family protein 0.0156 0.261 0.259
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0136 0.1185
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0095 0.1478 1
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0019 0.0087 0.0638
Leishmania major calcium motive p-type ATPase, putative 0.0034 0.0371 0.3441
Echinococcus multilocularis serotonin transporter 0.0098 0.1539 0.1516
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0081 0.0569
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0033 0.0353 0.0327
Echinococcus multilocularis BC026374 protein (S09 family) 0.0095 0.1478 0.1455
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0483 0.0458
Mycobacterium ulcerans hypothetical protein 0.0035 0.0389 0.2207
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0098 0.1539 0.1516
Toxoplasma gondii hypothetical protein 0.0047 0.0615 0.705
Echinococcus multilocularis fmrfamide receptor 0.004 0.0483 0.0458
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0127 0.01
Brugia malayi Carboxylesterase family protein 0.056 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0389 0.0363
Brugia malayi Dopamine receptor protein 2 0.004 0.0483 0.0458
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0926 0.1686
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0043 0.0528 0.0502
Loa Loa (eye worm) hypothetical protein 0.0019 0.0087 0.006
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0034 0.0371 0.0346
Plasmodium falciparum calcium-transporting ATPase 0.0034 0.0371 0.3673
Echinococcus granulosus alpha 1A adrenergic receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Schistosoma mansoni alpha-1 adrenergic receptor 0.004 0.0483 0.0458
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0043 0.0528 0.5646
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0034 0.0371 0.3814
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.0653
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.1185
Loa Loa (eye worm) hypothetical protein 0.0047 0.0615 0.059
Trypanosoma brucei trypanothione reductase 0.0062 0.0873 0.9372
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0615 0.059
Loa Loa (eye worm) solute carrier family 6 member 4 0.0098 0.1539 0.1516
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0019 0.0087 0.0994
Schistosoma mansoni amine GPCR 0.004 0.0483 0.0458
Onchocerca volvulus 0.004 0.0483 0.02
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Loa Loa (eye worm) melatonin receptor type 1A 0.004 0.0483 0.0458
Schistosoma mansoni growth hormone secretagogue receptor 0.004 0.0483 0.0458
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Trypanosoma brucei calcium-translocating P-type ATPase 0.0034 0.0371 0.3441
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.004 0.0483 0.0458
Echinococcus granulosus sex peptide receptor 0.004 0.0483 0.0458
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0064 0.0923 0.0899
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.056 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.261 0.259
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0615 0.705
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0043 0.0528 0.0502
Schistosoma mansoni peroxidasin 0.0156 0.261 0.259
Loa Loa (eye worm) hypothetical protein 0.0201 0.3435 0.3417
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0043 0.0528 0.5558
Loa Loa (eye worm) blistered cuticle protein 3 0.0156 0.261 0.259
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.3199
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0034 0.0371 0.0346
Loa Loa (eye worm) hypothetical protein 0.0201 0.3435 0.3417
Echinococcus granulosus carboxylesterase 5A 0.056 1 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0615 0.059
Schistosoma mansoni neuropeptide receptor 0.004 0.0483 0.0458
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0389 0.2207
Schistosoma mansoni opsin-like receptor 0.004 0.0483 0.0458
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.004 0.0483 0.0458
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0389 0.0816
Onchocerca volvulus 0.0098 0.1539 0.2445
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.004 0.0483 0.0458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0034 0.0371 0.0346
Loa Loa (eye worm) hypothetical protein 0.0098 0.1539 0.1516
Echinococcus multilocularis G protein coupled receptor 139 0.004 0.0483 0.0458
Onchocerca volvulus 0.0047 0.0615 0.0481
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Onchocerca volvulus 0.0064 0.0923 0.1135
Loa Loa (eye worm) glutathione reductase 0.0062 0.0873 0.0848
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0043 0.0528 0.0502
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0024 0.0186 0.021
Echinococcus multilocularis neuropeptide receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni sodium/chloride dependent transporter 0.0201 0.3435 0.3417
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0019 0.0087 0.006
Echinococcus granulosus Na:K ATPase alpha subunit 0.0034 0.0371 0.0346
Mycobacterium ulcerans beta-lactamase 0.0035 0.0389 0.2207
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.004 0.0483 0.0458
Brugia malayi Na,K-ATPase alpha subunit 0.0043 0.0528 0.0502
Echinococcus granulosus bloom syndrome protein 0.0021 0.0127 0.01
Loa Loa (eye worm) hypothetical protein 0.031 0.5419 0.5406
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0034 0.0371 0.6504
Schistosoma mansoni biogenic amine receptor 0.004 0.0483 0.0458
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0389 0.2207
Echinococcus granulosus para nitrobenzyl esterase 0.0095 0.1478 0.1455
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0615 0.059
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0034 0.0371 0.0346
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0483 0.0458
Onchocerca volvulus 0.0047 0.0615 0.0481
Schistosoma mansoni gliotactin 0.0095 0.1478 0.1455
Leishmania major P-type ATPase, putative 0.0034 0.0371 0.3441
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0389 0.3649
Echinococcus granulosus neuropeptide FF receptor 2 0.004 0.0483 0.0458
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0024 0.0186 0.016
Trichomonas vaginalis cation-transporting ATPase, putative 0.0043 0.0528 0.3199
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0064 0.0923 0.0899
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus granulosus G protein coupled receptor 139 0.004 0.0483 0.0458
Schistosoma mansoni opsin-like receptor 0.004 0.0483 0.0458
Schistosoma mansoni ap endonuclease 0.0018 0.0081 0.0054
Echinococcus granulosus acetylcholinesterase 0.056 1 1
Echinococcus multilocularis calcium transporting atpase 0.0034 0.0371 0.0346
Loa Loa (eye worm) hypothetical protein 0.0095 0.1478 0.1455
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0035 0.0389 0.0363
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0615 0.059
Loa Loa (eye worm) hypothetical protein 0.002 0.012 0.0094
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Brugia malayi GnHR receptor homolog 0.004 0.0483 0.0458
Onchocerca volvulus 0.004 0.0483 0.02
Schistosoma mansoni amine GPCR 0.004 0.0483 0.0458
Echinococcus multilocularis fmrfamide receptor 0.004 0.0483 0.0458
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0615 0.059
Plasmodium falciparum thioredoxin reductase 0.0021 0.0136 0.07
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Echinococcus multilocularis orexin receptor type 2 0.004 0.0483 0.0458
Trypanosoma brucei P-type H+-ATPase, putative 0.0027 0.0243 0.1922
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0043 0.0528 0.0502
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0043 0.0528 0.5558
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0081 0.0569
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0926 0.0902
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0034 0.0371 0.0346
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Echinococcus granulosus peroxidasin 0.0156 0.261 0.259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Echinococcus granulosus nervana 2 0.0064 0.0923 0.0899
Onchocerca volvulus 0.0064 0.0923 0.1135
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0043 0.0528 0.5558
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Schistosoma mansoni hypothetical protein 0.004 0.0483 0.0458
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0021 0.0136 0.0146
Onchocerca volvulus 0.004 0.0483 0.02
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0081 0.0054
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0561 0.0536
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0043 0.0528 0.6047
Onchocerca volvulus Protein cereblon homolog 0.0292 0.5092 1
Echinococcus granulosus somatostatin receptor 0.004 0.0483 0.0458
Brugia malayi Blistered cuticle protein 3 0.0156 0.261 0.259
Echinococcus multilocularis neuroligin 0.0095 0.1478 0.1455
Schistosoma mansoni adenoreceptor 0.004 0.0483 0.0458
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0389 0.0816
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0024 0.0186 0.021
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0019 0.0087 0.0638
Onchocerca volvulus 0.0156 0.261 0.4722
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0043 0.0528 0.0502
Brugia malayi Dopamine receptor protein 1 0.004 0.0483 0.0458
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0064 0.0923 0.0899
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0043 0.0528 0.3199
Echinococcus multilocularis neuropeptide receptor 0.004 0.0483 0.0458
Echinococcus multilocularis nervana 2 0.0064 0.0923 0.0899
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0561 0.0536
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0483 0.0458
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0615 0.059
Brugia malayi Thioredoxin reductase 0.0062 0.0873 0.0848
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0483 0.0458
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0483 0.0458
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.0892
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Brugia malayi beta-lactamase 0.0035 0.0389 0.0363
Echinococcus multilocularis serotonin receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.004 0.0483 0.0458
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0483 0.0458
Schistosoma mansoni peptide (allatostatin)-like receptor 0.004 0.0483 0.0458
Echinococcus multilocularis G-protein coupled receptor, putative 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0035 0.0389 0.0363
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0136 1
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0483 0.0458
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0081 0.0003
Onchocerca volvulus 0.004 0.0483 0.02
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni thyroid hormone receptor 0.0133 0.2177 0.2156
Echinococcus granulosus g protein coupled receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Plasmodium falciparum transporter, putative 0.0047 0.0615 0.6751
Plasmodium vivax P-type ATPase4, putative 0.0043 0.0528 0.6033
Leishmania major hypothetical protein, conserved 0.0035 0.0389 0.3649
Schistosoma mansoni opsin-like receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.1185
Onchocerca volvulus 0.0156 0.261 0.4722
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0021 0.0136 0.0653
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0021 0.0136 0.07
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.3199
Echinococcus granulosus neuropeptide receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0201 0.3435 0.3417
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.261 0.259
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis para nitrobenzyl esterase 0.0095 0.1478 0.1455
Mycobacterium ulcerans carboxylesterase, LipT 0.0095 0.1478 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0201 0.3435 0.3417
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0389 0.2207
Loa Loa (eye worm) hypothetical protein 0.0098 0.1539 0.1516
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0615 0.059
Trichomonas vaginalis spcc417.12 protein, putative 0.0095 0.1478 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0098 0.1539 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0634 0.061
Echinococcus granulosus BC026374 protein S09 family 0.0095 0.1478 0.1455
Loa Loa (eye worm) RecQ helicase 0.0021 0.0127 0.01
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0127 0.033
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis somatostatin receptor 0.004 0.0483 0.0458
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0034 0.0371 0.3441
Schistosoma mansoni amine GPCR 0.004 0.0483 0.0458
Echinococcus granulosus nervana 2 0.0064 0.0923 0.0899
Onchocerca volvulus 0.0043 0.0528 0.0295
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0389 0.2207
Echinococcus multilocularis nervana 2 0.0064 0.0923 0.0899
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0034 0.0371 0.0346
Schistosoma mansoni hypothetical protein 0.0292 0.5092 0.5079
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0021 0.0136 0.0653
Onchocerca volvulus 0.004 0.0483 0.02
Trypanosoma brucei P-type H+-ATPase, putative 0.0027 0.0243 0.1922
Onchocerca volvulus 0.004 0.0483 0.02
Onchocerca volvulus 0.004 0.0483 0.02
Brugia malayi RE15519p 0.004 0.0483 0.0458
Trypanosoma cruzi P-type H+-ATPase, putative 0.0027 0.0243 0.2382
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.1185
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0081 0.0054
Echinococcus multilocularis g protein coupled receptor 0.004 0.0483 0.0458
Trichomonas vaginalis cation-transporting ATPase, putative 0.0027 0.0243 0.1163
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0098 0.1539 0.1516
Brugia malayi Tachykinin-like peptides receptor 99D 0.004 0.0483 0.0458
Echinococcus multilocularis biogenic amine (5HT) receptor 0.004 0.0483 0.0458
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0047 0.0615 0.059
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0561 0.0536
Brugia malayi beta-lactamase family protein 0.0035 0.0389 0.0363
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0021 0.0136 0.011
Brugia malayi follicle stimulating hormone receptor 0.0265 0.4597 0.4582
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Trypanosoma cruzi P-type H+-ATPase, putative 0.0019 0.0087 0.0638
Echinococcus granulosus serotonin receptor 0.004 0.0483 0.0458
Echinococcus multilocularis nervana 2 0.0064 0.0923 0.0899
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0032 0.0006
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0064 0.0923 0.0899
Echinococcus granulosus thioredoxin glutathione reductase 0.0062 0.0873 0.0848
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0389 0.2207
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) beta-lactamase 0.0035 0.0389 0.0363
Loa Loa (eye worm) carboxylesterase 0.0095 0.1478 0.1455
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0043 0.0528 0.0502
Brugia malayi G protein-coupled receptor F59B2.13 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0064 0.0923 0.0899
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0389 0.401
Echinococcus multilocularis carboxylesterase 5A 0.056 1 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0615 0.059
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0043 0.0528 0.0502
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0428 0.0403
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0023
Leishmania major P-type H -ATPase, putative 0.0027 0.0243 0.1922
Loa Loa (eye worm) calcium ATPase 0.0024 0.0186 0.016
Entamoeba histolytica hypothetical protein, conserved 0.0292 0.5092 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.004 0.0483 0.0458
Brugia malayi Serotonin receptor 0.004 0.0483 0.0458
Toxoplasma gondii NADPH-glutathione reductase 0.0021 0.0136 0.1556
Brugia malayi Carboxylesterase family protein 0.0095 0.1478 0.1455
Mycobacterium tuberculosis Conserved protein 0.0035 0.0389 0.0816
Loa Loa (eye worm) hypothetical protein 0.0047 0.0615 0.059
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0043 0.0528 0.529
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0561 0.0536
Echinococcus granulosus orexin receptor type 2 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0049 0.0634 0.061
Loa Loa (eye worm) hypothetical protein 0.0043 0.0528 0.0502
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0095 0.1478 0.3698
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.0892
Brugia malayi beta-lactamase family protein 0.0035 0.0389 0.0363
Schistosoma mansoni histamine h1 receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0292 0.5092 0.5079
Onchocerca volvulus 0.004 0.0483 0.02
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0923 0.0899
Onchocerca volvulus 0.004 0.0483 0.02
Toxoplasma gondii hypothetical protein 0.0047 0.0615 0.705
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0389 0.0816
Echinococcus multilocularis acetylcholinesterase 0.056 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0483 0.0458
Onchocerca volvulus Peroxidasin homolog 0.0156 0.261 0.4722
Plasmodium vivax glutathione reductase, putative 0.0062 0.0873 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0021 0.0136 0.0653
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Brugia malayi Animal haem peroxidase family protein 0.0156 0.261 0.259
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Mycobacterium tuberculosis Conserved protein 0.0035 0.0389 0.0816
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0034 0.0371 0.3814
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0095 0.1478 0.1455
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0389 0.0816
Treponema pallidum NADH oxidase 0.0021 0.0136 0.0378
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0615 0.705
Brugia malayi putative neuropeptide receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0047 0.0615 0.059
Echinococcus multilocularis sodium and chloride dependent glycine 0.0201 0.3435 0.3417
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.0873 0.9408
Schistosoma mansoni ATPase 0.0043 0.0528 0.0502
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0483 0.0458
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0095 0.1478 0.1455
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0201 0.3435 0.3417
Mycobacterium tuberculosis Carboxylesterase LipT 0.0095 0.1478 0.3698
Onchocerca volvulus 0.004 0.0483 0.02
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni neuropeptide receptor 0.004 0.0483 0.0458
Plasmodium falciparum glutathione reductase 0.0021 0.0136 0.07
Loa Loa (eye worm) hypothetical protein 0.0098 0.1539 0.1516
Echinococcus multilocularis acetylcholinesterase 0.056 1 1
Echinococcus multilocularis geminin 0.0334 0.5868 0.5857
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1996 0.1975
Onchocerca volvulus Chorion peroxidase homolog 0.0156 0.261 0.4722
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0389 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0923 0.0899
Schistosoma mansoni sodium/chloride dependent transporter 0.0201 0.3435 0.3417
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Brugia malayi ORL1-like opioid receptor 0.004 0.0483 0.0458
Schistosoma mansoni transmemberane protein 0.0064 0.0923 0.0899
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Leishmania major calcium-translocating P-type ATPase 0.0043 0.0528 0.529
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.0653
Loa Loa (eye worm) hypothetical protein 0.0047 0.0615 0.059
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0923 0.0899
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0561 0.0536
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.004 0.0483 0.0458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Brugia malayi Carboxylesterase family protein 0.0095 0.1478 0.1455
Plasmodium falciparum glutathione reductase 0.0062 0.0873 1
Echinococcus granulosus hypothetical protein 0.004 0.0483 0.0458
Mycobacterium tuberculosis Conserved protein 0.0035 0.0389 0.0816
Onchocerca volvulus 0.0095 0.1478 0.2315
Schistosoma mansoni acetylcholinesterase 0.0095 0.1478 0.1455
Brugia malayi gonadotropin-releasing hormone receptor 2 0.004 0.0483 0.0458
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0043 0.0528 0.529
Echinococcus granulosus calcium transporting atpase 0.0034 0.0371 0.0346
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0032 0.0006
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0043 0.0528 0.3199
Echinococcus granulosus 7tm_1 domain containing protein 0.004 0.0483 0.0458
Onchocerca volvulus 0.0095 0.1478 0.2315
Echinococcus granulosus geminin 0.0334 0.5868 0.5857
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0043 0.0528 0.6047
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.261 0.259
Schistosoma mansoni hypothetical protein 0.0334 0.5868 0.5857
Echinococcus granulosus neuropeptide receptor 0.004 0.0483 0.0458
Brugia malayi G protein-coupled receptor 0.004 0.0483 0.0458
Brugia malayi calcium ATPase 0.0016 0.003 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0021 0.0136 0.011
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0021 0.0136 0.0395
Plasmodium vivax thioredoxin reductase, putative 0.0062 0.0873 1
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0483 0.0458
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0615 0.059
Echinococcus multilocularis tachykinin peptides receptor 99D 0.034 0.5981 0.597
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0615 0.705
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0483 0.0458
Brugia malayi neuropeptide F receptor 0.004 0.0483 0.0458
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0483 0.0458
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0021 0.0136 0.0395
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.3199
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0043 0.0528 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.004 0.0483 0.02
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Giardia lamblia NADH oxidase lateral transfer candidate 0.0021 0.0136 0.1235
Loa Loa (eye worm) acetylcholinesterase 1 0.056 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0353 0.0327
Onchocerca volvulus Peroxidase homolog 0.0156 0.261 0.4722
Echinococcus granulosus peptide allatostatin:somatostatin 0.004 0.0483 0.0458
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.004 0.0483 0.0458
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.002 0.012 0.0094
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0483 0.0458
Echinococcus multilocularis neuropeptide receptor A26 0.004 0.0483 0.0458
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0029 0.0277 0.5563
Brugia malayi Animal haem peroxidase family protein 0.0156 0.261 0.259
Onchocerca volvulus 0.004 0.0483 0.02
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0034 0.0371 0.0346
Leishmania major calcium-transporting ATPase, putative 0.0034 0.0371 0.3441
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0095 0.1478 0.1455
Brugia malayi hypothetical protein 0.0119 0.1922 0.1901
Loa Loa (eye worm) norepinephrine transporter 0.0098 0.1539 0.1516
Loa Loa (eye worm) hypothetical protein 0.0095 0.1478 0.1455
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.3859 1
Echinococcus multilocularis g protein coupled receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0389 0.0363
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0047 0.0615 1
Schistosoma mansoni hypothetical protein 0.0033 0.0353 0.0327
Echinococcus granulosus g-protein coupled receptor 0.004 0.0483 0.0458
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0483 0.0458
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0389 0.0363
Onchocerca volvulus 0.004 0.0483 0.02
Onchocerca volvulus 0.004 0.0483 0.02
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0043 0.0528 0.529
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.3199
Onchocerca volvulus 0.004 0.0483 0.02
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0081 0.0054
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.004 0.0483 0.0458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.1185
Brugia malayi Serotonin/octopamine receptor family protein 7 0.004 0.0483 0.0458
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0483 0.0458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.1185
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0389 0.0816
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0389 0.0363
Schistosoma mansoni myosin xvIII 0.004 0.0483 0.0458
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0389 0.0816
Brugia malayi hypothetical protein 0.0047 0.0615 0.059
Echinococcus granulosus neuropeptide receptor A26 0.004 0.0483 0.0458
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0483 0.0458
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0043 0.0528 0.3199
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0047 0.0615 0.059
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0389 0.401
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0034 0.0371 0.0346
Echinococcus multilocularis g-protein coupled receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni biogenic amine receptor 0.004 0.0483 0.0458
Echinococcus granulosus g protein coupled receptor 0.004 0.0483 0.0458
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0035 0.0389 0.0363
Onchocerca volvulus 0.004 0.0483 0.02
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Schistosoma mansoni hypothetical protein 0.004 0.0483 0.0458
Brugia malayi Animal haem peroxidase family protein 0.0156 0.261 0.259
Echinococcus granulosus serotonin transporter 0.0098 0.1539 0.1516
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.004 0.0483 0.0458
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.261 0.259
Trichomonas vaginalis cation-transporting ATPase, putative 0.0043 0.0528 0.3199
Echinococcus granulosus neuroligin 0.0095 0.1478 0.1455
Brugia malayi sulfakinin receptor protein 0.0294 0.5132 0.5119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0136 0.1185
Loa Loa (eye worm) hypothetical protein 0.0035 0.0389 0.0363
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0926 0.0902
Brugia malayi hypothetical protein 0.0292 0.5092 0.5079
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0127 0.01
Echinococcus multilocularis sodium and chloride dependent glycine 0.0201 0.3435 0.3417
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0483 0.0458
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0046 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0483 0.0458
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0021 0.0136 0.1556
Echinococcus multilocularis dro:myosuppressin receptor 0.004 0.0483 0.0458
Brugia malayi Animal haem peroxidase family protein 0.0156 0.261 0.259
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.0095 0.1478 0.1455
Echinococcus multilocularis sex peptide receptor 0.004 0.0483 0.0458
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0034 0.0371 0.0346
Echinococcus multilocularis allatostatin A receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0029 0.0277 0.0251
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0081 0.0054
Loa Loa (eye worm) carboxylesterase 0.0095 0.1478 0.1455
Loa Loa (eye worm) hypothetical protein 0.0035 0.0389 0.0363
Loa Loa (eye worm) hypothetical protein 0.056 1 1
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0615 0.704
Echinococcus granulosus acetylcholinesterase 0.056 1 1
Schistosoma mansoni amine GPCR 0.004 0.0483 0.0458
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.004 0.0483 0.0458
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0483 0.0458
Onchocerca volvulus 0.0047 0.0615 0.0481
Brugia malayi Dopamine receptor 0.004 0.0483 0.0458
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0615 0.059
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0081 0.0891
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0034 0.0371 0.6504
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0923 0.0899
Schistosoma mansoni neuropeptide receptor 0.004 0.0483 0.0458
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0483 0.0458
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1996 0.1975
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0047 0.0615 0.059
Onchocerca volvulus 0.004 0.0483 0.02
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0923 0.0899
Trichomonas vaginalis cation-transporting ATPase, putative 0.0043 0.0528 0.3199
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0265 0.4597 0.4582
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0389 0.2207
Schistosoma mansoni peroxidasin 0.0156 0.261 0.259
Echinococcus multilocularis g protein coupled receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) E1-E2 ATPase 0.0027 0.0243 0.0217
Echinococcus granulosus neuropeptide s receptor 0.004 0.0483 0.0458
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0019 0.0087 0.0012
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0389 0.0816
Echinococcus multilocularis alpha 1A adrenergic receptor 0.004 0.0483 0.0458
Onchocerca volvulus Peroxidasin homolog 0.0156 0.261 0.4722
Schistosoma mansoni ap endonuclease 0.0018 0.0081 0.0054
Echinococcus granulosus protein cereblon 0.0292 0.5092 0.5079
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0029 0.0277 0.0519
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.3199
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0043 0.0528 0.529
Trypanosoma cruzi P-type H+-ATPase, putative 0.0027 0.0243 0.2382
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0064 0.0923 0.0899
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0371 0.2081
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0483 0.0458
Brugia malayi Melatonin receptor type 1A 0.004 0.0483 0.0458
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0483 0.0458
Mycobacterium tuberculosis Probable oxidoreductase 0.0021 0.0136 0.0146
Brugia malayi AKH receptor 0.004 0.0483 0.0458
Schistosoma mansoni hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0047 0.0615 0.059
Schistosoma mansoni amine GPCR 0.004 0.0483 0.0458
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0021 0.0136 0.011
Schistosoma mansoni hypothetical protein 0.0334 0.5868 0.5857
Onchocerca volvulus 0.0095 0.1478 0.2315
Brugia malayi neuropeptide F receptor 0.004 0.0483 0.0458
Trypanosoma brucei calcium-transporting ATPase, putative 0.002 0.012 0.0471
Onchocerca volvulus 0.0095 0.1478 0.2315
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Toxoplasma gondii P-type ATPase PMA1 0.0027 0.0243 0.2785
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0019 0.0087 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Brugia malayi Carboxylesterase family protein 0.0095 0.1478 0.1455
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0389 0.0363
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0043 0.0528 0.529
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0029 0.0277 0.0251
Onchocerca volvulus 0.0156 0.261 0.4722
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0926 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0389 0.0363
Plasmodium falciparum thioredoxin reductase 0.0062 0.0873 1
Echinococcus granulosus nervana 2 0.0064 0.0923 0.0899
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Echinococcus multilocularis thioredoxin glutathione reductase 0.0062 0.0873 0.0848
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0615 0.059
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0047 0.0615 0.059
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0136 0.0653
Brugia malayi hypothetical protein 0.0095 0.1478 0.1455
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0634 0.061
Echinococcus multilocularis neuropeptide s receptor 0.004 0.0483 0.0458
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0483 0.0458
Echinococcus multilocularis thyroid hormone receptor alpha 0.0133 0.2177 0.2156
Brugia malayi hypothetical protein 0.0156 0.261 0.259
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0136 0.1185
Schistosoma mansoni thyroid hormone receptor 0.0133 0.2177 0.2156
Echinococcus granulosus nervana 2 0.0064 0.0923 0.0899
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0926 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0095 0.1478 0.3698
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0043 0.0528 0.0892
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Onchocerca volvulus Dual oxidase homolog 0.0156 0.261 0.4722
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.056 1 1
Toxoplasma gondii P-type ATPase4, putative 0.0043 0.0528 0.6047
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Echinococcus multilocularis protein cereblon 0.0292 0.5092 0.5079
Echinococcus multilocularis peroxidasin 0.0156 0.261 0.259
Brugia malayi G-protein coupled receptor 0.004 0.0483 0.0458
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0926 0.0902
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.004 0.0483 0.0458
Schistosoma mansoni neuropeptide f receptor 76f 0.004 0.0483 0.0458
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.004 0.0483 0.02
Echinococcus multilocularis nervana 2 0.0064 0.0923 0.0899
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Loa Loa (eye worm) TYRA-2 protein 0.004 0.0483 0.0458
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0136 1
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0483 0.0458
Brugia malayi Serotonin receptor 0.004 0.0483 0.0458
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0923 0.0899
Mycobacterium leprae Probable lipase LipE 0.0035 0.0389 1
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0064 0.0923 0.0899
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Loa Loa (eye worm) hypothetical protein 0.0156 0.261 0.259
Mycobacterium ulcerans lipase LipD 0.0035 0.0389 0.2207
Trichomonas vaginalis glutathione reductase, putative 0.0021 0.0136 0.0395
Brugia malayi hypothetical protein 0.004 0.0483 0.0458
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0095 0.1478 0.1455
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0021 0.0136 0.0146
Echinococcus granulosus tachykinin peptides receptor 99D 0.034 0.5981 0.597
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0483 0.0458
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0483 0.0458
Trichomonas vaginalis esterase, putative 0.0035 0.0389 0.2207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0127 0.033
Loa Loa (eye worm) hypothetical protein 0.004 0.0483 0.0458
Plasmodium vivax amine transporter, putative 0.0047 0.0615 0.704
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0483 0.0458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0483 0.0458
Trypanosoma cruzi calcium-transporting ATPase, putative 0.002 0.012 0.1013
Onchocerca volvulus Peroxidase homolog 0.0156 0.261 0.4722
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.004 0.0483 0.0458
Loa Loa (eye worm) carboxylesterase 0.056 1 1
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0043 0.0528 0.0502

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.025 uM Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNA ChEMBL. 16246557
EC50 (functional) = 0.025 uM Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNA ChEMBL. 16246557
EC50 (functional) = 15 uM Inhibition of [3H]glycine uptake in cells transfected with human GlyT2 cDNA ChEMBL. 16246557
EC50 (functional) = 15 uM Inhibition of [3H]glycine uptake in cells transfected with human GlyT2 cDNA ChEMBL. 16246557
Ratio EC50 (functional) = 600 Selectivity for human GlyT2 over human GlyT1 ChEMBL. 16246557

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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