Detailed information for compound 416313

Basic information

Technical information
  • TDR Targets ID: 416313
  • Name: 2-[5-[2-[[3-(2,3,4-trihydroxyphenyl)benzoyl]a mino]phenyl]thiophen-2-yl]acetic acid
  • MW: 461.486 | Formula: C25H19NO6S
  • H donors: 5 H acceptors: 6 LogP: 4.16 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)Cc1ccc(s1)c1ccccc1NC(=O)c1cccc(c1)c1ccc(c(c1O)O)O
  • InChi: 1S/C25H19NO6S/c27-20-10-9-17(23(30)24(20)31)14-4-3-5-15(12-14)25(32)26-19-7-2-1-6-18(19)21-11-8-16(33-21)13-22(28)29/h1-12,27,30-31H,13H2,(H,26,32)(H,28,29)
  • InChiKey: QGYWYIDXKZJFHK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[5-[2-[[3-(2,3,4-trihydroxyphenyl)benzoyl]amino]phenyl]-2-thienyl]acetic acid
  • 2-[5-[2-[[oxo-[3-(2,3,4-trihydroxyphenyl)phenyl]methyl]amino]phenyl]-2-thienyl]acetic acid
  • 2-[5-[2-[[3-(2,3,4-trihydroxyphenyl)phenyl]carbonylamino]phenyl]thiophen-2-yl]ethanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens selectin P (granule membrane protein 140kDa, antigen CD62) Starlite/ChEMBL References
Homo sapiens selectin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-coA synthetase, putative 0.0095 0.0726 0.8667
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Brugia malayi pregnancy-associated plasma protein-A 0.0038 0.0193 0.0179
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0197 0.0183
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0101 0.0775 0.0838
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0029 0.0031
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0095 0.0726 0.0784
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0078 0.0567 0.0567
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0111 0.1165
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1122 0.1214
Brugia malayi beta-lactamase family protein 0.0038 0.0197 0.0183
Mycobacterium ulcerans polyketide synthase Pks13 0.008 0.058 0.0566
Echinococcus granulosus AMP dependent ligase 0.0019 0.0015 0.0016
Onchocerca volvulus 0.0038 0.0193 0.1059
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0193
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.0726 0.0781
Onchocerca volvulus 0.0038 0.0193 0.1059
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.094 0.094
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0835 0.0821
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0057 0.0367 0.0352
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0029 0.0029
Mycobacterium ulcerans polyketide synthase 0.0057 0.0367 0.0352
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0101 0.0775 0.0762
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0095 0.0726 0.0712
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0197 0.2223
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0095 0.0726 0.8667
Plasmodium vivax apical sushi protein, putative 0.0038 0.0193 0.2511
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0029 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0726 0.0712
Echinococcus multilocularis long chain fatty acid transport protein 4 0.1014 0.924 1
Brugia malayi beta-lactamase family protein 0.0038 0.0197 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0029 0.0014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0197 0.0213
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.1014 0.924 1
Brugia malayi MH2 domain containing protein 0.0118 0.094 0.0927
Onchocerca volvulus 0.0038 0.0193 0.1059
Loa Loa (eye worm) hypothetical protein 0.0154 0.1266 0.1266
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0726 0.0796
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1122 0.1214
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0057 0.0367 0.0389
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0095 0.0726 0.0784
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0197 0.0203
Loa Loa (eye worm) hypothetical protein 0.0233 0.2001 0.2001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0029 0.0031
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0095 0.0726 0.8667
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0197 0.2223
Schistosoma mansoni hypothetical protein 0.0691 0.625 0.6764
Schistosoma mansoni hypothetical protein 0.0049 0.0301 0.0326
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0111 0.1344
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0095 0.0726 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0029 0.0029
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0044 0.0254 0.0262
Mycobacterium ulcerans Type I modular polyketide synthase 0.0053 0.0336 0.0321
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0095 0.0726 1
Plasmodium falciparum apical sushi protein 0.0038 0.0193 0.2511
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.1292 0.1279
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0029 0.0031
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0301 0.0326
Entamoeba histolytica hypothetical protein 0.0038 0.0193 0.2174
Mycobacterium leprae Probable lipase LipE 0.0038 0.0197 0.02
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0029 0.0014
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0101 0.0775 0.0838
Echinococcus multilocularis muscleblind protein 0.0154 0.1266 0.137
Echinococcus multilocularis AMP dependent ligase 0.0019 0.0015 0.0016
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0835 0.0916
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0043 0.024 0.0225
Brugia malayi hypothetical protein 0.0038 0.0193 0.0178
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0567 0.7769
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0835 0.0903
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0029 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0029 0.0014
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0111 0.1165
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.0726 0.0781
Toxoplasma gondii rhoptry neck protein RON9 0.0038 0.0193 0.2511
Schistosoma mansoni hypothetical protein 0.0049 0.0301 0.0326
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0835 1
Loa Loa (eye worm) fatty acid synthase 0.0053 0.0329 0.0329
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.2001 0.2166
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0082 0.0089
Brugia malayi AMP-binding enzyme family protein 0.003 0.0117 0.0102
Loa Loa (eye worm) hypothetical protein 0.0038 0.0197 0.0197
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0095 0.0726 0.0784
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0111 0.1165
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0015 0.5
Mycobacterium ulcerans Type I modular polyketide synthase 0.0053 0.0336 0.0321
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0057 0.0367 0.0386
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0053 0.0336 0.0353
Mycobacterium ulcerans acetyl-CoA synthetase 0.0095 0.0726 0.0712
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0029 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0726 0.0712
Leishmania major acetyl-CoA synthetase, putative 0.0095 0.0726 0.0796
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0111 0.1165
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0015 0.000001809
Brugia malayi steroid hormone receptor 0.002 0.0029 0.0014
Echinococcus multilocularis c4b binding protein beta chain 0.0038 0.0193 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0029 0.0014
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0035 0.0163 0.2077
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0029 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0197 0.2223
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0052 0.0321 0.0339
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0015 0.0016
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0111 0.1344
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0095 0.0726 0.0784
Loa Loa (eye worm) hypothetical protein 0.0154 0.1266 0.1266
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0145 0.1187 0.1187
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0197 0.0213
Brugia malayi hypothetical protein 0.0038 0.0193 0.0179
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0022 0.0042 0.0033
Onchocerca volvulus 0.0038 0.0193 0.1059
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0029 0.0031
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0111 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0197 0.0197
Schistosoma mansoni thyroid hormone receptor 0.002 0.0029 0.0031
Mycobacterium ulcerans polyketide synthase 0.0053 0.0336 0.0321
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0197 0.0197
Brugia malayi hypothetical protein 0.0038 0.0193 0.0179
Onchocerca volvulus 0.0038 0.0193 0.1059
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0029 0.0031
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0053 0.0336 0.0353
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0111 0.1344
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0029 0.0014
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0197 0.0183
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0053 0.0336 0.0356
Loa Loa (eye worm) hypothetical protein 0.0095 0.0726 0.0725
Brugia malayi 6-phosphofructokinase 0.0107 0.0835 0.0821
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0029 0.0031
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0029 0.0031
Schistosoma mansoni acetyl-CoA synthetase 0.0095 0.0726 0.0785
Echinococcus granulosus flap endonuclease 1 0.0026 0.0082 0.0089
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0038 0.0197 0.0203
Schistosoma mansoni c4b-binding protein beta chain 0.0038 0.0193 0.0209
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1122 0.1214
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0095 0.0726 0.0785
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0193
Schistosoma mansoni thyroid hormone receptor 0.002 0.0029 0.0031
Brugia malayi Bromodomain containing protein 0.0038 0.0196 0.0182
Mycobacterium tuberculosis Conserved protein 0.0038 0.0197 0.0203
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.094 0.094
Mycobacterium tuberculosis Conserved protein 0.0038 0.0197 0.0203
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0015 0.0003
Schistosoma mansoni ap endonuclease 0.0019 0.0015 0.0016
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0197 0.0203
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0053 0.0336 0.0321
Echinococcus granulosus long chain fatty acid transport protein 4 0.1014 0.924 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0111 0.1165
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.003 0.0123 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0029 0.0014
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0193 0.0209
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0726 0.0712
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0029 0.0031
Schistosoma mansoni nuclear hormone receptor 0.002 0.0029 0.0031
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0193 0.0209
Mycobacterium ulcerans polyketide synthase Pks9 0.0035 0.0169 0.0154
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0095 0.0726 0.0796
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0197 0.2565
Loa Loa (eye worm) hypothetical protein 0.0038 0.0197 0.0197
Onchocerca volvulus 0.0145 0.1187 0.7442
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Loa Loa (eye worm) acyl carrier protein 0.0024 0.0069 0.0069
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0051 0.0055
Brugia malayi PHD-finger family protein 0.0025 0.0073 0.0058
Onchocerca volvulus 0.0095 0.0726 0.4478
Plasmodium falciparum flap endonuclease 1 0.0026 0.0082 0.0941
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0095 0.0726 0.0785
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0111 0.1344
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0101 0.0775 0.0838
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0029 0.0031
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0175 0.0189
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0111 0.1344
Brugia malayi hypothetical protein 0.005 0.031 0.0296
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0835 0.0903
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0029 0.0031
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0082 0.0815
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0101 0.0778 0.0764
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0809 0.7339 0.7943
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0029 0.0014
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0029 0.0031
Onchocerca volvulus 0.0038 0.0193 0.1059
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0095 0.0726 0.0712
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.1292 0.1279
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0038 0.0193 0.0193
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1122 0.1214
Brugia malayi phosphofructokinase 0.0107 0.0835 0.0821
Trichomonas vaginalis antibiotic synthetase, putative 0.0095 0.0726 0.8667
Trichomonas vaginalis esterase, putative 0.0038 0.0197 0.2223
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.1292 0.1292
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0111 0.1344
Schistosoma mansoni hypothetical protein 0.0035 0.0167 0.0181
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0197 0.0214
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0029 0.0031
Schistosoma mansoni coup transcription factor 0.002 0.0029 0.0031
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0193
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0111 0.1165
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0095 0.0726 0.0785
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0049 0.0301 0.0301
Schistosoma mansoni zinc finger protein 0.002 0.0023 0.0025
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0029 0.0014
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0051 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0029 0.0014
Loa Loa (eye worm) hypothetical protein 0.0071 0.0496 0.0496
Entamoeba histolytica hypothetical protein 0.0038 0.0193 0.2174
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0015 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0726 0.0712
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.0119
Echinococcus multilocularis geminin 0.0691 0.625 0.6764
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0095 0.0726 0.8667
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0101 0.0775 0.0762
Brugia malayi nuclear receptor NHR-88 0.002 0.0029 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0726 0.0712
Mycobacterium tuberculosis Probable thioesterase TesA 0.0044 0.0254 0.0265
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0095 0.0726 0.0712
Leishmania major hypothetical protein, conserved 0.0078 0.0567 0.0622
Onchocerca volvulus 0.0038 0.0193 0.1059
Echinococcus granulosus c4b binding protein beta chain 0.0038 0.0193 0.0209
Loa Loa (eye worm) hypothetical protein 0.0095 0.0726 0.0725
Mycobacterium tuberculosis Polyketide synthase Pks13 0.008 0.058 0.0624
Echinococcus granulosus FTZ F1 alpha 0.002 0.0029 0.0031
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0082 0.009
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0057 0.0367 0.0389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0029 0.0029
Toxoplasma gondii rhoptry neck protein RON1 0.0038 0.0193 0.2511
Mycobacterium leprae Probable polyketide synthase Pks1 0.0057 0.0367 0.0386
Mycobacterium ulcerans Type I modular polyketide synthase 0.0053 0.0336 0.0321
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0101 0.0775 0.0835
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0835 0.0903
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0029 0.0014
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0051 0.0055
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0283 0.0268
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0197 0.0213
Echinococcus granulosus muscleblind protein 0.0154 0.1266 0.137
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0052 0.0321 0.0339
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0167 0.0181
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0015 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0726 0.0712
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0029 0.0031
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0095 0.0726 0.0712
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0095 0.0726 0.0712
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0053 0.0336 0.0321
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.2001 0.2166
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0175 0.0189
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0029 0.0031
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0095 0.0726 0.0712
Brugia malayi hypothetical protein 0.0038 0.0193 0.0179
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0095 0.0726 0.0785
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0095 0.0726 0.0784
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0029 0.0031
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0029 0.0031
Onchocerca volvulus 0.0038 0.0197 0.1083
Onchocerca volvulus 0.0038 0.0197 0.1083
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0193
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0726 0.0712
Mycobacterium leprae Polyketide synthase Pks13 0.008 0.058 0.0621
Schistosoma mansoni flap endonuclease-1 0.0023 0.0059 0.0064
Loa Loa (eye worm) hypothetical protein 0.0038 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0015 0.0003
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0567 0.7769
Schistosoma mansoni bromodomain containing protein 0.0063 0.0427 0.0463
Onchocerca volvulus 0.0048 0.0283 0.1633
Mycobacterium ulcerans acyl-CoA synthetase 0.0101 0.0775 0.0762
Onchocerca volvulus 0.0101 0.0775 0.4799
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.1096 1 1
Brugia malayi hypothetical protein 0.0038 0.0193 0.0179
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0197 0.2223
Loa Loa (eye worm) AMP-binding enzyme family protein 0.1096 1 1
Schistosoma mansoni hypothetical protein 0.0021 0.0033 0.0036
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0835 1
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0006 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0145 0.1187 0.1173
Echinococcus granulosus geminin 0.0691 0.625 0.6764
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0015 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0835 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0029 0.0014
Entamoeba histolytica acyl-CoA synthetase, putative 0.0095 0.0726 0.8667
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0029 0.0031
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0053 0.0336 0.0356
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1122 0.1214
Trichomonas vaginalis antibiotic synthetase, putative 0.0095 0.0726 0.8667
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0082 0.0815
Echinococcus granulosus zinc finger protein 0.002 0.0023 0.0025
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0301 0.0286
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0394 0.0427
Onchocerca volvulus 0.0038 0.0193 0.1059
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0726 0.0712
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0726 0.0712
Schistosoma mansoni survival motor neuron protein 0.0048 0.0283 0.0306
Schistosoma mansoni hypothetical protein 0.0048 0.0283 0.0306
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0029 0.0031
Mycobacterium ulcerans beta-lactamase 0.0038 0.0197 0.0183
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0111 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0095 0.0726 0.0784
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0193
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0603 0.0649
Brugia malayi hypothetical protein 0.0078 0.0567 0.0553
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0197 0.0203
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0835 0.0835
Schistosoma mansoni hypothetical protein 0.0049 0.0301 0.0326
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0726 0.0712
Loa Loa (eye worm) hypothetical protein 0.0103 0.0794 0.0794
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0835 0.0904
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.1122 0.1122
Loa Loa (eye worm) hypothetical protein 0.0095 0.0726 0.0725
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1122 0.1214
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0835 1
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0057 0.0367 0.0389
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1122 0.1214
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.0726 0.0781
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0053 0.0336 0.0356
Schistosoma mansoni hypothetical protein 0.0049 0.0301 0.0326
Mycobacterium ulcerans lipase LipD 0.0038 0.0197 0.0183
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0111 0.1165
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0029 0.0014
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0197 0.0203
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0197 0.2223
Echinococcus multilocularis muscleblind protein 1 0.0154 0.1266 0.137
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0394 0.0427
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0111 0.1165
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0835 1
Brugia malayi hypothetical protein 0.0038 0.0193 0.0179
Brugia malayi beta-lactamase 0.0038 0.0197 0.0183
Toxoplasma gondii ABC1 family protein 0.0038 0.0197 0.2565
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0111 0.1165
Leishmania major acetyl-CoA synthetase, putative 0.0095 0.0726 0.0796
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0043 0.024 0.0247
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0101 0.0775 0.0762
Schistosoma mansoni ap endonuclease 0.0019 0.0015 0.0016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0029 0.0031
Onchocerca volvulus 0.0095 0.0726 0.4478
Brugia malayi hypothetical protein 0.0038 0.0193 0.0179
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0095 0.0726 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0111 0.1344
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0301 0.0286
Brugia malayi Muscleblind-like protein 0.0154 0.1266 0.1253
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0726 0.0712
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0029 0.0031
Echinococcus granulosus GPCR family 2 0.0049 0.0301 0.0326
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0029 0.0029
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0035 0.0169 0.0154
Echinococcus granulosus C type lectin domian containing protein 0.0038 0.0193 0.0209
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0095 0.0726 0.0784
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0833 0.0819
Entamoeba histolytica hypothetical protein 0.0038 0.0193 0.2174
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0015 0.0016
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.1014 0.924 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0197 0.0203
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0111 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0029 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0197 0.2223
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0029 0.0014
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0033 0.0033
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0095 0.0726 0.0784
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0101 0.0775 0.0762
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0095 0.0726 0.0785
Brugia malayi Sushi domain 0.0038 0.0193 0.0179
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0082 0.0089
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.004 0.0215 0.2809
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0193 0.0209
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0835 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0301 0.0326
Brugia malayi hypothetical protein 0.0233 0.2001 0.1989
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0057 0.0367 0.0386
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0029 0.0014
Mycobacterium ulcerans thioesterase TesA 0.0044 0.0254 0.0239
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0101 0.0775 0.0761
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0029 0.0031
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0835 0.0903
Brugia malayi GCC2 and GCC3 family protein 0.0038 0.0193 0.0179
Schistosoma mansoni hypothetical protein 0.0107 0.0833 0.0902
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.008 0.058 0.0624
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0082 0.7
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0029 0.0014
Leishmania major hypothetical protein, conserved 0.0038 0.0197 0.0216
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0726 0.0796
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0029 0.0031
Mycobacterium ulcerans hypothetical protein 0.0095 0.0726 0.0712
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.1001 0.9117 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0095 0.0726 0.0785
Onchocerca volvulus 0.0038 0.0197 0.1083
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0197 0.0213
Loa Loa (eye worm) beta-lactamase 0.0038 0.0197 0.0197
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0167 0.0181
Loa Loa (eye worm) hypothetical protein 0.0038 0.0197 0.0197
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0835 0.0903
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0044 0.0246 0.0257
Toxoplasma gondii type I fatty acid synthase, putative 0.007 0.0489 0.6676
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.1001 0.9117 1
Brugia malayi hypothetical protein 0.0038 0.0193 0.0179
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0057 0.0367 0.0352
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0567 0.7769
Loa Loa (eye worm) hypothetical protein 0.0038 0.0197 0.0197
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0043 0.0237 0.0237
Entamoeba histolytica hypothetical protein 0.0038 0.0193 0.2174
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0095 0.0726 0.0781
Echinococcus multilocularis C type lectin domian containing protein 0.0038 0.0193 0.0209
Brugia malayi Flap endonuclease-1 0.0026 0.0082 0.0067
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0835 0.0835
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0095 0.0726 0.0712
Loa Loa (eye worm) hypothetical protein 0.0038 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0156 0.1292 0.1292
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0726 0.0712
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0835 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0095 0.0726 0.0712
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0043 0.024 0.0225
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0567 0.7769
Schistosoma mansoni FFA transport protein 0.1014 0.924 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0145 0.1187 0.129
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.1122 0.1109
Onchocerca volvulus 0.0038 0.0193 0.1059
Leishmania major fatty acid transporter protein-like protein 0.1001 0.9117 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0029 0.0029
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0197 0.0203
Echinococcus multilocularis zinc finger protein 0.002 0.0023 0.0025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0101 0.0775 0.9275
Loa Loa (eye worm) hypothetical protein 0.0107 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0041 0.0219 0.0219
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0035 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0038 0.0197 0.0197
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0567 0.0614
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0726 0.0712
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0835 0.0901
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0301 0.0326
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0015 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0726 0.0796
Loa Loa (eye worm) hypothetical protein 0.0095 0.0726 0.0725
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0197 0.0203
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0197 0.0183
Loa Loa (eye worm) hypothetical protein 0.0095 0.0726 0.0725
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0726 0.0712
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.211 0.2304
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0835 0.0835
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0726 0.0712
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0082 0.0816
Echinococcus multilocularis GPCR, family 2 0.0049 0.0301 0.0326
Mycobacterium ulcerans thioesterase 0.0044 0.0254 0.0239
Brugia malayi 6-phosphofructokinase 0.0107 0.0835 0.0821
Loa Loa (eye worm) hypothetical protein 0.0042 0.0233 0.0233
Schistosoma mansoni hypothetical protein 0.0038 0.0193 0.0209
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0082 0.0941
Plasmodium vivax acetyl-CoA synthetase, putative 0.0095 0.0726 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0567 0.0614
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0197 0.0214
Toxoplasma gondii type I fatty acid synthase, putative 0.0038 0.0194 0.2515
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0029 0.0031
Loa Loa (eye worm) oxidoreductase 0.0095 0.0726 0.0725
Brugia malayi ecdysteroid receptor 0.002 0.0029 0.0014
Toxoplasma gondii propionate-CoA ligase 0.0095 0.0726 1
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0197 0.0203
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0082 0.0941
Mycobacterium ulcerans hypothetical protein 0.0038 0.0197 0.0183
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0301 0.0326
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0835 1
Brugia malayi Bromodomain containing protein 0.0075 0.0536 0.0522
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0197 0.02
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0835 1
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0567 0.6734
Schistosoma mansoni hypothetical protein 0.0691 0.625 0.6764
Onchocerca volvulus Fatty acid synthase homolog 0.0096 0.0732 0.4521
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0301 0.0301
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0101 0.0775 0.0838
Onchocerca volvulus 0.0188 0.1585 1
Onchocerca volvulus 0.0038 0.0193 0.1059
Brugia malayi nuclear hormone receptor 0.002 0.0029 0.0014

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.8 uM Inhibition of human P-selectin after 2 hrs ChEMBL. 17302397
IC50 (binding) = 5.8 uM Inhibition of human P-selectin after 2 hrs ChEMBL. 17302397
IC50 (binding) = 9.8 uM Inhibition of human L-selectin after 2 hrs ChEMBL. 17302397
IC50 (binding) = 9.8 uM Inhibition of human L-selectin after 2 hrs ChEMBL. 17302397
IC50 (binding) = 132 uM Inhibition of human E-selectin after 2 hrs ChEMBL. 17302397
IC50 (binding) = 132 uM Inhibition of human E-selectin after 2 hrs ChEMBL. 17302397
Inhibition (functional) = 55 % Inhibition of attachment of HL60 cells to P-selectin at 109 uM after 5 mins ChEMBL. 17302397
Inhibition (functional) = 55 % Inhibition of attachment of HL60 cells to P-selectin at 109 uM after 5 mins ChEMBL. 17302397
Inhibition (functional) = 61 % Inhibition of attachment of HL60 cells to E-selectin at 109 uM after 5 mins ChEMBL. 17302397
Inhibition (functional) = 61 % Inhibition of attachment of HL60 cells to E-selectin at 109 uM after 5 mins ChEMBL. 17302397

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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