Detailed information for compound 418960

Basic information

Technical information
  • TDR Targets ID: 418960
  • Name: 6-[4-(2-methylsulfonylphenyl)piperazin-1-yl]- N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanami de
  • MW: 483.666 | Formula: C27H37N3O3S
  • H donors: 1 H acceptors: 3 LogP: 3.69 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1S(=O)(=O)C
  • InChi: 1S/C27H37N3O3S/c1-34(32,33)26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31)
  • InChiKey: NXWSVHVNLWEBAY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[4-(2-methylsulfonylphenyl)piperazin-1-yl]-N-tetralin-1-yl-hexanamide
  • 6-[4-(2-methylsulfonylphenyl)-1-piperazinyl]-N-(1-tetralinyl)hexanamide
  • 6-[4-(2-mesylphenyl)piperazino]-N-tetralin-1-yl-hexanamide
  • 6-[4-(2-mesylphenyl)piperazin-1-yl]-N-tetralin-1-yl-hexanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References
Rattus norvegicus Serotonin 7 (5-HT7) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis biogenic amine (5HT) receptor Get druggable targets OG5_133074 All targets in OG5_133074
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133074 All targets in OG5_133074
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133074 All targets in OG5_133074
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Serotonin 2a (5-HT2a) receptor   471 aa 435 aa 23.0 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 2a (5-HT2a) receptor   471 aa 405 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus biogenic amine 5HT receptor 0.0159 0.0604 0.0661
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0139 0.0526 0.0575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.1879 0.5847
Schistosoma mansoni hypothetical protein 0.0164 0.0628 0.0687
Loa Loa (eye worm) hypothetical protein 0.0469 0.1879 0.2056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.2356 0.7359
Brugia malayi hypothetical protein 0.0014 0.0012 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.1879 0.5847
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0012 0.0063
Loa Loa (eye worm) hypothetical protein 0.0139 0.0526 0.0575
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0033 0.0036
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0273 0.1074 0.1175
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2485 0.667
Schistosoma mansoni hypothetical protein 0.0102 0.0373 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0078 0.0085
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0139 0.0526 0.0175
Plasmodium falciparum cysteine proteinase falcipain 3 0.0469 0.1879 1
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0012 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0078 0.0085
Loa Loa (eye worm) hypothetical protein 0.0139 0.0526 0.0575
Trypanosoma cruzi cysteine peptidase, putative 0.0469 0.1879 0.1594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0526 0.1561
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0078 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.1879 0.5847
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.0526 0.1561
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0033 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.1879 0.5847
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0033 0.0036
Brugia malayi Cathepsin L-like precursor 0.0469 0.1879 0.2056
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0033 0.0036
Plasmodium vivax unspecified product 0.0273 0.1074 0.4158
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Brugia malayi Papain family cysteine protease containing protein 0.0139 0.0526 0.0575
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0273 0.1074 0.1175
Brugia malayi nuclear hormone receptor 0.003 0.0078 0.0085
Leishmania major cathepsin L-like protease 0.0469 0.1879 0.5606
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0585 0.2356 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0033 0.0036
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0123
Brugia malayi hypothetical protein 0.0019 0.0033 0.0036
Entamoeba histolytica cysteine protease, putative 0.0273 0.1074 0.4483
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0085
Onchocerca volvulus 0.0027 0.0065 0.0347
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0036
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0139 0.0526 0.0175
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0033 0.0036
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0078 0.0078
Entamoeba histolytica cysteine protease, putative 0.0273 0.1074 0.4483
Schistosoma mansoni biogenic amine (5HT) receptor 0.0466 0.1866 0.2042
Brugia malayi Cathepsin L-like precursor 0.0335 0.133 0.1455
Brugia malayi fibroinase precursor 0.0139 0.0526 0.0575
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0078 0.0085
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0012 0.0013
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0033 0.0033
Echinococcus granulosus cathepsin L 0.0273 0.1074 0.1175
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0078 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0469 0.1879 0.5847
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.1879 0.5847
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0078 0.0085
Plasmodium vivax vivapain-2 0.0469 0.1879 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0078 0.0085
Entamoeba histolytica cysteine protease, putative 0.0469 0.1879 0.7946
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0159 0.0604 0.0661
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0206 0.0303
Schistosoma mansoni thyroid hormone receptor 0.003 0.0078 0.0085
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.133 0.411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 0.1074 0.3299
Loa Loa (eye worm) hypothetical protein 0.0134 0.0501 0.0549
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0139 0.0526 0.1561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.1879 0.5847
Echinococcus multilocularis cathepsin L 0.0139 0.0526 0.0526
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0147 0.0161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.1879 0.5847
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0033 0.0036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0078 0.0078
Echinococcus granulosus expressed protein 0.0379 0.1509 0.1651
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0021
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0013 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.2356 0.7359
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.0567 0.062
Entamoeba histolytica cysteine proteinase, putative 0.0469 0.1879 0.7946
Giardia lamblia Cathepsin B precursor 0.0788 0.319 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.1879 0.5847
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0069
Brugia malayi cathepsin B-like cysteine proteinase 0.2237 0.9139 1
Brugia malayi hypothetical protein 0.0016 0.0019 0.0021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0078 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2485 0.667
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0139 0.0526 0.0175
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0033 0.0036
Schistosoma mansoni biogenic amine (5HT) receptor 0.0159 0.0604 0.0661
Onchocerca volvulus 0.0469 0.1879 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.1879 0.5847
Entamoeba histolytica cysteine proteinase, putative 0.0273 0.1074 0.4483
Echinococcus granulosus cathepsin l cysteine peptidase 0.0469 0.1879 0.2056
Toxoplasma gondii preprocathepsin c precursor, putative 0.0139 0.0526 0.1342
Brugia malayi Papain family cysteine protease containing protein 0.0469 0.1879 0.2056
Echinococcus granulosus lamin 0.0027 0.0065 0.0071
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0585 0.2356 1
Brugia malayi hypothetical protein 0.0016 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.03 0.1185 0.1296
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.0567 0.062
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0788 0.319 0.349
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0019 0.0021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0078 0.0078
Echinococcus granulosus biogenic amine 5HT receptor 0.0466 0.1866 0.2042
Schistosoma mansoni cathepsin F (C01 family) 0.0469 0.1879 0.2056
Brugia malayi Papain family cysteine protease containing protein 0.0139 0.0526 0.0575
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0206 0.0206
Echinococcus multilocularis expressed protein 0.0379 0.1509 0.1509
Brugia malayi Cathepsin L-like precursor 0.0469 0.1879 0.2056
Echinococcus multilocularis cathepsin b 0.2237 0.9139 0.9139
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0033 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0078 0.0085
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0012 0.0012
Entamoeba histolytica cysteine protease, putative 0.0139 0.0526 0.2121
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.1879 0.5847
Entamoeba histolytica hypothetical protein 0.0139 0.0526 0.2121
Brugia malayi nuclear receptor RXR 0.0016 0.0019 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2485 0.667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0526 0.1561
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0021
Entamoeba histolytica cysteine protease, putative 0.0273 0.1074 0.4483
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0012 0.0013
Loa Loa (eye worm) cysteine protease 0.0469 0.1879 0.2056
Entamoeba histolytica cysteine proteinase, putative 0.0335 0.133 0.5585
Loa Loa (eye worm) DR-78 0.0014 0.0012 0.0013
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.015 0.0567 0.062
Brugia malayi Cathepsin L-like precursor 0.0469 0.1879 0.2056
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0039 0.0113 0.0113
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0033 0.0036
Onchocerca volvulus 0.0469 0.1879 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0065 0.0071
Echinococcus multilocularis musashi 0.0027 0.0065 0.0065
Echinococcus multilocularis GPCR, family 2 0.0047 0.0147 0.0147
Brugia malayi nuclear receptor RXR 0.0014 0.0012 0.0013
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0469 0.1879 0.2056
Loa Loa (eye worm) cathepsin B 0.0788 0.319 0.349
Echinococcus multilocularis serotonin receptor 0.0159 0.0604 0.0604
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0139 0.0526 0.0575
Plasmodium vivax vivapain-1 0.0273 0.1074 0.4158
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0078 0.0085
Brugia malayi cathepsin L-like precursor 0.0335 0.133 0.1455
Loa Loa (eye worm) hypothetical protein 0.0102 0.0373 0.0408
Entamoeba histolytica cysteine proteinase, putative 0.0273 0.1074 0.4483
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Toxoplasma gondii cathepsin CPL 0.0469 0.1879 0.574
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.1879 0.5847
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0286 0.1127 1
Schistosoma mansoni hypothetical protein 0.0164 0.0628 0.0687
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0466 0.1866 0.1866
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0078 0.0078
Trypanosoma cruzi cysteine peptidase, putative 0.0617 0.2485 0.2296
Leishmania major cathepsin L-like protease 0.0469 0.1879 0.5606
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0033 0.0036
Echinococcus multilocularis geminin 0.0164 0.0628 0.0628
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0078 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0526 0.1561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2485 0.667
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2485 0.667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.1879 0.5847
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.1879 0.5847
Onchocerca volvulus 0.0029 0.0073 0.0386
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0033 0.0036
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0078 0.0085
Schistosoma mansoni cathepsin s 0.0134 0.0501 0.0549
Brugia malayi Cathepsin L-like precursor 0.0469 0.1879 0.2056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0526 0.1561
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0469 0.1879 1
Entamoeba histolytica cysteine proteinase, putative 0.0273 0.1074 0.4483
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0483 0.1936 0.1661
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0078 0.0416
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0033 0.0033
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0139 0.0526 0.1561
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0078 0.0416
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0096 0.0105
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0033 0.0036
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0147 0.0161
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0012 0.0013
Brugia malayi nuclear hormone receptor 0.0014 0.0012 0.0013
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2237 0.9139 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0078 0.0085
Brugia malayi GH02984p 0.0353 0.1402 0.1534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0526 0.1561
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0788 0.319 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0147 0.0161
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0033 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2485 0.667
Schistosoma mansoni cathepsin B (C01 family) 0.0139 0.0526 0.0575
Entamoeba histolytica cysteine proteinase, putative 0.0273 0.1074 0.4483
Loa Loa (eye worm) fibroinase 0.0469 0.1879 0.2056
Leishmania major cathepsin L-like protease 0.0469 0.1879 0.5606
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0139 0.0526 0.2121
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0788 0.319 0.3112
Trypanosoma cruzi cysteine peptidase, putative 0.0617 0.2485 0.2296
Echinococcus multilocularis serotonin receptor 0.0159 0.0604 0.0604
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0065 0.0071
Schistosoma mansoni lamin 0.0027 0.0065 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.1879 0.5847
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.0526 0.1561
Brugia malayi Papain family cysteine protease containing protein 0.0139 0.0526 0.0575
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2485 0.667
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0207 0.0226
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0033 0.0033
Trypanosoma cruzi major cysteine proteinase, putative 0.0287 0.1132 0.073
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0073 0.0079
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0012 0.0013
Echinococcus granulosus cysteine protease 0.0273 0.1074 0.1175
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0273 0.1074 0.1175
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.1879 0.5847
Schistosoma mansoni hypothetical protein 0.0047 0.0147 0.0161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0147 0.0147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.1879 0.5847
Entamoeba histolytica cysteine proteinase 1, putative 0.0273 0.1074 0.4483
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0078 0.0085
Brugia malayi CXXC zinc finger family protein 0.0029 0.0073 0.0079
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0033 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0078 0.0078
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0012 0.0013
Loa Loa (eye worm) ctsf protein 0.0469 0.1879 0.2056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.1879 0.5847
Schistosoma mansoni hypothetical protein 0.0035 0.0096 0.0105
Toxoplasma gondii cathepsin B 0.0788 0.319 1
Leishmania major cathepsin L-like protease 0.0469 0.1879 0.5606
Brugia malayi cathepsin Z-like cysteine proteinase 0.0139 0.0526 0.0575
Brugia malayi Papain family cysteine protease containing protein 0.0273 0.1074 0.1175
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0033 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0078 0.0085
Schistosoma mansoni cathepsin F (C01 family) 0.0335 0.133 0.1455
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0078 0.0085
Loa Loa (eye worm) hypothetical protein 0.0159 0.0604 0.0661
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.1879 0.5847
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0008
Giardia lamblia Fructose-bisphosphate aldolase 0.0585 0.2356 0.687
Schistosoma mansoni coup transcription factor 0.003 0.0078 0.0085
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0085
Trypanosoma cruzi cruzipain precursor, putative 0.0617 0.2485 0.2296
Loa Loa (eye worm) hypothetical protein 0.0335 0.133 0.1455
Plasmodium vivax unspecified product 0.0139 0.0526 0.0175
Schistosoma mansoni cpg binding protein 0.0031 0.0079 0.0087
Loa Loa (eye worm) hypothetical protein 0.0027 0.0065 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0078 0.0085
Brugia malayi nuclear receptor NHR-88 0.003 0.0078 0.0085
Loa Loa (eye worm) hypothetical protein 0.0134 0.0501 0.0549
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0021
Echinococcus granulosus sodium:glucose cotransporter 2 0.0039 0.0113 0.0123
Echinococcus granulosus cathepsin b 0.2237 0.9139 1
Onchocerca volvulus 0.003 0.0078 0.0416
Onchocerca volvulus Cathepsin F homolog 0.0469 0.1879 1
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0078 0.0085
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0139 0.0526 0.2121
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0013 0.0014
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0012 0.0013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0147 0.0161
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0078 0.0078
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0012 0.0013
Trypanosoma cruzi cysteine proteinase, putative 0.0273 0.1074 0.0663
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0036
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0147 0.0161
Echinococcus multilocularis high affinity choline transporter 1 0.0353 0.1402 0.1402
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.2356 0.7359
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.1879 0.5847
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0078 0.0085
Schistosoma mansoni thyroid hormone receptor 0.003 0.0078 0.0085
Trypanosoma cruzi cysteine protease, putative 0.0273 0.1074 0.0663
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0134 0.0501 0.0549
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0078 0.0085
Echinococcus multilocularis cathepsin L cysteine protease 0.0469 0.1879 0.1879
Brugia malayi cathepsin L-like cysteine proteinase 0.0139 0.0526 0.0575
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0033 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.0273 0.1074 0.0663
Brugia malayi Cathepsin L-like precursor 0.0134 0.0501 0.0549
Onchocerca volvulus 0.0014 0.0012 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.2356 0.7359
Onchocerca volvulus 0.0469 0.1879 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.1879 0.5847
Brugia malayi Cathepsin L-like precursor 0.0469 0.1879 0.2056
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0469 0.1879 0.1879
Leishmania major cathepsin L-like protease 0.0617 0.2485 0.7639
Echinococcus multilocularis cathepsin L 0.0273 0.1074 0.1074
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0139 0.0526 0.0575
Entamoeba histolytica hypothetical protein 0.0035 0.0096 0.0273
Loa Loa (eye worm) hypothetical protein 0.0134 0.0501 0.0549
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0469 0.1879 0.5847
Schistosoma mansoni nuclear receptor 0.0014 0.0012 0.0013
Echinococcus granulosus cpg binding protein 0.0031 0.0079 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0139 0.0526 0.1561
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0012 0.0013
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0139 0.0526 0.0575
Schistosoma mansoni cathepsin C 0.0139 0.0526 0.0575
Entamoeba histolytica cysteine proteinase, putative 0.0469 0.1879 0.7946
Brugia malayi steroid hormone receptor 0.003 0.0078 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0012 0.0012
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0033 0.0036
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0065 0.0071
Onchocerca volvulus Cathepsin L homolog 0.0469 0.1879 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0021
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0033 0.0033
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0788 0.319 1
Leishmania major cathepsin L-like protease 0.0617 0.2485 0.7639
Entamoeba histolytica cysteine protease, putative 0.0139 0.0526 0.2121
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0078 0.0085
Echinococcus granulosus cathepsin L cysteine proteinase 0.0469 0.1879 0.2056
Echinococcus granulosus dnaJ subfamily B 0.0415 0.1658 0.1814
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0139 0.0526 0.0175
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0078 0.0085
Brugia malayi cathepsin F-like cysteine proteinase 0.0139 0.0526 0.0575
Brugia malayi nuclear receptor NHR-88 0.0014 0.0012 0.0013
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0139 0.0526 0.0575
Echinococcus granulosus cathepsin L 0.0139 0.0526 0.0575
Echinococcus multilocularis cysteine protease 0.0469 0.1879 0.1879
Entamoeba histolytica cysteine protease, putative 0.0273 0.1074 0.4483
Schistosoma mansoni high-affinity choline transporter 0.0353 0.1402 0.1534
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0526 0.0575
Schistosoma mansoni inositol transporter 0.0039 0.0113 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0139 0.0526 0.1561
Brugia malayi Cathepsin L-like precursor 0.0335 0.133 0.1455
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0033 0.0036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0078 0.0085
Entamoeba histolytica cysteine protease, putative 0.0273 0.1074 0.4483
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0078 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0139 0.0526 0.1561
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0019 0.0021
Onchocerca volvulus 0.0039 0.0113 0.06
Echinococcus granulosus cathepsin b 0.2237 0.9139 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0139 0.0526 0.0575
Onchocerca volvulus 0.0139 0.0526 0.2797
Echinococcus multilocularis cathepsin b 0.2237 0.9139 0.9139
Plasmodium vivax serine-repeat antigen (SERA) 0.0139 0.0526 0.0175
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0033 0.0036
Schistosoma mansoni sodium/solute symporter 0.0039 0.0113 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2485 0.667
Echinococcus granulosus cathepsin l1 0.0469 0.1879 0.2056
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0019 0.0021
Giardia lamblia Cathepsin B precursor 0.0788 0.319 1
Echinococcus granulosus cathepsin l1 0.0335 0.133 0.1455
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0139 0.0526 0.0575
Entamoeba histolytica cysteine protease, putative 0.0273 0.1074 0.4483
Brugia malayi ecdysteroid receptor 0.003 0.0078 0.0085
Onchocerca volvulus Cathepsin L homolog 0.0469 0.1879 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0078 0.0085
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.0567 0.062
Echinococcus multilocularis lamin dm0 0.0027 0.0065 0.0065
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0019 0.0021
Toxoplasma gondii cathepsin CPC2 0.0139 0.0526 0.1342
Onchocerca volvulus 0.0469 0.1879 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0139 0.0526 0.0175
Entamoeba histolytica cysteine protease, putative 0.0273 0.1074 0.4483
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0526 0.0575
Onchocerca volvulus 0.0014 0.0012 0.0063
Trypanosoma brucei cysteine peptidase C (CPC) 0.0788 0.319 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0033 0.0036
Brugia malayi cathepsin Z-like cysteine proteinase 0.0139 0.0526 0.0575
Entamoeba histolytica cysteine protease, putative 0.0273 0.1074 0.4483
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0021
Schistosoma mansoni cathepsin S (C01 family) 0.0139 0.0526 0.0575
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2485 0.667
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0033 0.0036
Entamoeba histolytica hypothetical protein 0.0035 0.0096 0.0273
Entamoeba histolytica cysteine protease, putative 0.0139 0.0526 0.2121
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0012 0.0013
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0139 0.0526 0.0175
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.0526 0.1561
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0033 0.0036
Leishmania major cysteine peptidase A (CPA) 0.0469 0.1879 0.5606
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0033 0.0036
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Onchocerca volvulus 0.0335 0.133 0.708
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0286 0.1127 1
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0373 0.0408
Echinococcus granulosus sodium:myo inositol cotransporter 0.0039 0.0113 0.0123
Loa Loa (eye worm) hypothetical protein 0.2237 0.9139 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0012 0.0063
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0078 0.0085
Entamoeba histolytica cysteine protease, putative 0.0273 0.1074 0.4483
Onchocerca volvulus Cathepsin L homolog 0.0139 0.0526 0.2797
Trypanosoma cruzi cysteine proteinase, putative 0.0273 0.1074 0.0663
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0039 0.0113 0.0113
Entamoeba histolytica cysteine protease, putative 0.0273 0.1074 0.4483
Schistosoma mansoni inositol transporter 0.0039 0.0113 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0526 0.1561
Brugia malayi Cathepsin L-like cysteine proteinase 0.0335 0.133 0.1455
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0469 0.1879 0.2056
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0078 0.0085
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0134 0.0501 0.0549
Leishmania major cathepsin L-like protease 0.0469 0.1879 0.5606
Echinococcus granulosus sodium:glucose cotransporter 0.0039 0.0113 0.0123
Entamoeba histolytica cysteine protease, putative 0.0139 0.0526 0.2121
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2237 0.9139 1
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.1658 0.1658
Brugia malayi Sodium:solute symporter family protein 0.0039 0.0113 0.0123
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0012 0.0013
Schistosoma mansoni lamin 0.0027 0.0065 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.133 0.411
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2485 0.667
Schistosoma mansoni nuclear hormone receptor 0.003 0.0078 0.0085
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0012 0.0012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2237 0.9139 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0139 0.0526 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0078 0.0085
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0469 0.1879 0.5847
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.0526 0.1561
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0139 0.0526 0.1561
Brugia malayi PXA domain containing protein 0.0019 0.0033 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.1879 0.5847
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0033 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0078 0.0085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.2356 0.7359
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0078 0.0078
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0139 0.0526 0.0575
Brugia malayi nuclear receptor NHR-67 0.0014 0.0012 0.0013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0078 0.0416
Schistosoma mansoni cathepsin F (C01 family) 0.0469 0.1879 0.2056
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0033 0.0036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0096 0.0096
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0033 0.0036
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0078 0.0085
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0033 0.0033
Schistosoma mansoni intermediate filament proteins 0.0027 0.0065 0.0071
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0206 0.0225
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0033 0.0036
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0033 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0078 0.0085
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0007 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0206 0.0225
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0012 0.0013
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0096 0.0105
Toxoplasma gondii cathepsin CPC1 0.0139 0.0526 0.1342
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0006
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0078 0.0085
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0039 0.0113 0.0123
Entamoeba histolytica cysteine protease, putative 0.0139 0.0526 0.2121
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0033 0.0036
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0012 0.0013
Echinococcus granulosus GPCR family 2 0.0047 0.0147 0.0161
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0526 0.0575
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0035 0.0096 0.0273
Entamoeba histolytica cysteine protease, putative 0.0273 0.1074 0.4483
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.0526 0.1561
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.018 0.0218
Giardia lamblia Cathepsin B precursor 0.0788 0.319 1
Brugia malayi tailless protein 0.0014 0.0012 0.0013
Plasmodium falciparum cysteine proteinase falcipain 1 0.0273 0.1074 0.4054
Plasmodium vivax vivapain-3 0.0273 0.1074 0.4158
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0286 0.1127 0.5
Echinococcus granulosus FTZ F1 alpha 0.003 0.0078 0.0085
Brugia malayi intermediate filament protein 0.0027 0.0065 0.0071
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2237 0.9139 1
Onchocerca volvulus 0.0469 0.1879 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0078 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0617 0.2485 0.667
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.2356 0.7359
Brugia malayi Cathepsin L-like precursor 0.0469 0.1879 0.2056
Brugia malayi ecdysone receptor 0.0014 0.0012 0.0013
Brugia malayi cathepsin F-like cysteine proteinase 0.0134 0.0501 0.0549
Echinococcus multilocularis cpg binding protein 0.0031 0.0079 0.0079
Echinococcus multilocularis lamin 0.0027 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0139 0.0526 0.0575
Loa Loa (eye worm) hypothetical protein 0.0335 0.133 0.1455
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0139 0.0526 0.0175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 0.1074 0.3299
Brugia malayi cathepsin L precursor 0.0139 0.0526 0.0575
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0036
Echinococcus granulosus lamin dm0 0.0027 0.0065 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0036
Onchocerca volvulus 0.0469 0.1879 1
Schistosoma mansoni cpg binding protein 0.0031 0.0079 0.0087
Entamoeba histolytica cysteine protease, putative 0.0273 0.1074 0.4483
Brugia malayi Papain family cysteine protease containing protein 0.0273 0.1074 0.1175
Brugia malayi PXA domain containing protein 0.0019 0.0033 0.0036
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0526 0.0575
Onchocerca volvulus 0.0469 0.1879 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0147 0.0161
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0012 0.0013
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0033 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.2356 0.7359
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0036
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0469 0.1879 1
Brugia malayi hypothetical protein 0.03 0.1185 0.1296
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0047 0.0147 0.0161
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0033 0.0036
Loa Loa (eye worm) hypothetical protein 0.0139 0.0526 0.0575
Schistosoma mansoni hypothetical protein 0.0415 0.1658 0.1814
Brugia malayi hypothetical protein 0.0019 0.0033 0.0036
Echinococcus granulosus high affinity choline transporter 1 0.0353 0.1402 0.1534
Entamoeba histolytica cysteine proteinase 2 0.0273 0.1074 0.4483
Brugia malayi hypothetical protein 0.0014 0.0012 0.0013
Entamoeba histolytica cysteine protease, putative 0.0273 0.1074 0.4483
Loa Loa (eye worm) hypothetical protein 0.0335 0.133 0.1455
Schistosoma mansoni hypothetical protein 0.0047 0.0147 0.0161
Schistosoma mansoni cpg binding protein 0.0029 0.0073 0.0079
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0273 0.1074 0.0663
Plasmodium vivax serine-repeat antigen (SERA) 0.0139 0.0526 0.0175
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0033 0.0036
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0085
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0078 0.0085
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Echinococcus granulosus cathepsin L cysteine protease 0.0273 0.1074 0.1175
Loa Loa (eye worm) hypothetical protein 0.0353 0.1402 0.1534
Schistosoma mansoni nuclear receptor 0.0014 0.0012 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0078 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0078 0.0085
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0012 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0469 0.1879 0.5847
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0078 0.0085
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0078 0.0085
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0013
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0039 0.0113 0.0113
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0078 0.0078
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.2356 0.7359
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0012 0.0013
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0469 0.1879 0.1879
Onchocerca volvulus 0.0027 0.0065 0.0347
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2237 0.9139 1
Plasmodium vivax vivapain-2 0.0469 0.1879 1
Entamoeba histolytica cysteine protease, putative 0.0139 0.0526 0.2121
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.0526 0.0575
Echinococcus multilocularis cathepsin L cysteine protease 0.0469 0.1879 0.1879
Loa Loa (eye worm) hypothetical protein 0.0139 0.0526 0.0575
Brugia malayi hypothetical protein 0.0035 0.0096 0.0105
Schistosoma mansoni hypothetical protein 0.0047 0.0147 0.0161
Trypanosoma cruzi cysteine peptidase, putative 0.0617 0.2485 0.2296
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0078 0.0085
Entamoeba histolytica hypothetical protein 0.0035 0.0096 0.0273
Brugia malayi conserved hypotetical protein 0.0014 0.0012 0.0013
Echinococcus multilocularis solute carrier family 5 0.0039 0.0113 0.0113
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0012 0.0013
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0078 0.0085
Onchocerca volvulus 0.03 0.1185 0.6305
Echinococcus granulosus solute carrier family 5 0.0039 0.0113 0.0123
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0065 0.0071
Leishmania major cathepsin L-like protease 0.0617 0.2485 0.7639
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0019 0.0021
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0019 0.0021
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0139 0.0526 0.0175
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0206 0.0225
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0139 0.0526 0.0175
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0139 0.0526 0.1561
Loa Loa (eye worm) hypothetical protein 0.003 0.0078 0.0085
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0033 0.0036
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0078 0.0085
Echinococcus granulosus geminin 0.0164 0.0628 0.0687
Schistosoma mansoni zinc finger protein 0.0014 0.0012 0.0013
Echinococcus multilocularis cysteine protease 0.0469 0.1879 0.1879
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0526 0.1561
Treponema pallidum fructose-bisphosphate aldolase 0.0585 0.2356 0.5
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0139 0.0526 0.0575
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0078 0.0085
Trypanosoma cruzi major cysteine proteinase, putative 0.0139 0.0526 0.0028

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 38 % Displacement of [3H]ketanserin from 5HT2A receptor in Wistar Han rat cortex membranes ChEMBL. 15588097
Activity (binding) = 38 % Displacement of [3H]ketanserin from 5HT2A receptor in Wistar Han rat cortex membranes ChEMBL. 15588097
Inhibition (binding) = 32 % Displacement of [3H]spiroperidol from human recombinant Dopamine D2 long receptor at >1000 uM ChEMBL. 17649988
Inhibition (binding) = 32 % Displacement of [3H]spiroperidol from human recombinant Dopamine D2 long receptor at >1000 uM ChEMBL. 17649988
Inhibition (binding) = 38 % Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley cortex membrane at >4000 uM ChEMBL. 17649988
Inhibition (binding) = 38 % Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley cortex membrane at >4000 uM ChEMBL. 17649988
Ki (binding) = 298 nM Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells ChEMBL. 15588097
Ki (binding) = 298 nM Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells ChEMBL. 15588097
Ki (binding) > 1000 nM Displacement of [3H]spiroperidol from human recombinant Dopamine D2 long receptor ChEMBL. 17649988
Ki (binding) > 1000 nM Displacement of [3H]spiroperidol from human recombinant Dopamine D2 long receptor ChEMBL. 17649988
Ki (binding) = 3124 nM Displacement of [3H]8-OH-DPAT from 5HT1A receptor in Wistar Han rat hippocampal membranes ChEMBL. 15588097
Ki (binding) = 3124 nM Displacement of [3H]8-OH-DPAT from 5HT1A receptor in Wistar Han rat hippocampal membranes ChEMBL. 15588097
Ki (binding) > 4000 nM Displacement of [3H]ketanserin from 5HT2A receptor in Wistar Han rat cortex membranes ChEMBL. 15588097
Ki (binding) > 4000 nM Displacement of [3H]ketanserin from 5HT2A receptor in Wistar Han rat cortex membranes ChEMBL. 15588097

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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