Detailed information for compound 430734

Basic information

Technical information
  • TDR Targets ID: 430734
  • Name: N,N-diethyl-5-methyl-2-(thiophene-2-carbonyla mino)-4,5,6,7-tetrahydro-1-benzothiophene-3-c arboxamide
  • MW: 376.536 | Formula: C19H24N2O2S2
  • H donors: 1 H acceptors: 2 LogP: 5.01 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1c(NC(=O)c2cccs2)sc2c1CC(C)CC2)CC
  • InChi: 1S/C19H24N2O2S2/c1-4-21(5-2)19(23)16-13-11-12(3)8-9-14(13)25-18(16)20-17(22)15-7-6-10-24-15/h6-7,10,12H,4-5,8-9,11H2,1-3H3,(H,20,22)
  • InChiKey: UQKSYQYWUHUIEH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N-diethyl-5-methyl-2-(thiophene-2-carbonylamino)-4,5,6,7-tetrahydrobenzothiophene-3-carboxamide
  • N,N-diethyl-5-methyl-2-[[oxo(2-thienyl)methyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxamide
  • N,N-diethyl-5-methyl-2-(thiophen-2-ylcarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
  • N,N-diethyl-5-methyl-2-(2-thenoylamino)-4,5,6,7-tetrahydrobenzothiophene-3-carboxamide
  • N,N-diethyl-5-methyl-2-[[oxo-(2-thienyl)methyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinesin family member 11 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni kinesin eg-5 Get druggable targets OG5_128460 All targets in OG5_128460
Schistosoma japonicum ko:K10398 kinesin family member 11, putative Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium vivax kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Neospora caninum hypothetical protein Get druggable targets OG5_128460 All targets in OG5_128460
Candida albicans kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein Get druggable targets OG5_128460 All targets in OG5_128460
Toxoplasma gondii kinesin motor domain-containing protein Get druggable targets OG5_128460 All targets in OG5_128460
Echinococcus multilocularis kinesin family 1 Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium berghei kinesin-5, putative Get druggable targets OG5_128460 All targets in OG5_128460
Brugia malayi Kinesin motor domain containing protein Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium yoelii Kinesin motor domain, putative Get druggable targets OG5_128460 All targets in OG5_128460
Cryptosporidium parvum kinesin-like boursin, putative Get druggable targets OG5_128460 All targets in OG5_128460
Giardia lamblia Kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium knowlesi kinesin-5, putative Get druggable targets OG5_128460 All targets in OG5_128460
Entamoeba histolytica kinesin, putative Get druggable targets OG5_128460 All targets in OG5_128460
Candida albicans kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein Get druggable targets OG5_128460 All targets in OG5_128460
Cryptosporidium hominis kinesin-like boursin Get druggable targets OG5_128460 All targets in OG5_128460
Echinococcus granulosus kinesin family 1 Get druggable targets OG5_128460 All targets in OG5_128460
Loa Loa (eye worm) kinesin-like protein KLP2 Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium falciparum kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glycogen phosphorylase, putative 0.0791 0.4894 1
Schistosoma mansoni tyrosine kinase 0.0148 0.0828 0.0828
Schistosoma mansoni tyrosine kinase 0.0242 0.142 0.142
Loa Loa (eye worm) matrix metalloproteinase 0.0022 0.0027 0.0027
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0044 0.0167 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0035 0.0055
Echinococcus multilocularis Glycosyl transferase, family 35 0.0791 0.4894 0.4923
Loa Loa (eye worm) hypothetical protein 0.0069 0.0326 0.0327
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0044 0.0167 1
Echinococcus granulosus sodium and chloride dependent glycine 0.1588 0.994 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0054 0.0234 0.0235
Brugia malayi Matrixin family protein 0.0022 0.0027 0.0027
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1588 0.994 1
Echinococcus multilocularis acetylcholinesterase 0.0073 0.035 0.0352
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0128 0.0702 0.2131
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0116
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0262 0.0262
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0008 0.0008
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0753 0.0758
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0262 0.1243
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0035 0.0132
Mycobacterium ulcerans lipase LipD 0.0036 0.0115 0.0523
Giardia lamblia Kinase, CMGC GSK 0.0058 0.0254 0.0504
Schistosoma mansoni tyrosine kinase 0.0148 0.0828 0.0828
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0044 0.0167 0.0487
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0128 0.0702 0.2131
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0309 0.1846 0.1846
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0058 0.0254 0.1309
Loa Loa (eye worm) hypothetical protein 0.0073 0.035 0.0352
Echinococcus granulosus tar DNA binding protein 0.0067 0.0311 0.0313
Brugia malayi Fli-1 protein 0.0245 0.1437 0.1446
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1341 0.1349
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0115 0.0116
Echinococcus multilocularis carboxylesterase 5A 0.0073 0.035 0.0352
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0164 0.0165
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0254 0.0504
Onchocerca volvulus 0.0309 0.1846 0.3756
Loa Loa (eye worm) kinesin-like protein KLP2 0.0032 0.0093 0.0094
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0027
Entamoeba histolytica glycogen phosphorylase, putative 0.0791 0.4894 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0533 0.3264 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0025 0.005 0.005
Mycobacterium tuberculosis Conserved protein 0.0036 0.0115 0.0523
Schistosoma mansoni ets-related 0.0245 0.1437 0.1437
Echinococcus multilocularis c src tyrosine kinase 0.0025 0.005 0.005
Schistosoma mansoni tyrosine kinase 0.0054 0.0234 0.0234
Plasmodium vivax amine transporter, putative 0.0309 0.1846 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0027
Trypanosoma brucei methionine aminopeptidase, putative 0.0044 0.0167 0.0487
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0251 0.0251
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0008 0.0008
Echinococcus granulosus carboxylesterase 5A 0.0073 0.035 0.0352
Onchocerca volvulus 0.0058 0.0254 0.0496
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0044 0.0167 0.0487
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0008 0.0008
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0494 0.0994
Echinococcus granulosus mitogen activated protein kinase 14 0.0533 0.3264 0.3284
Entamoeba histolytica protein kinase, putative 0.0058 0.0254 0.0504
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0309 0.1846 0.1846
Echinococcus multilocularis epidermal growth factor receptor 0.0458 0.2786 0.2803
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0309 0.1846 0.1857
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0309 0.1846 0.1857
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0309 0.1846 0.1857
Brugia malayi CHE-14 protein 0.0041 0.0149 0.015
Onchocerca volvulus 0.0031 0.0084 0.0148
Schistosoma mansoni hypothetical protein 0.0376 0.2268 0.2268
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0262 0.0264
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0115 0.0116
Echinococcus multilocularis serotonin transporter 0.0309 0.1846 0.1857
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0058 0.0254 0.0254
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0311 0.0311
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0149 0.015
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0035 0.0083
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0115 0.0523
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0309 0.1846 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0186 0.0186
Toxoplasma gondii methionine aminopeptidase 0.0044 0.0167 0.083
Loa Loa (eye worm) hypothetical protein 0.1588 0.994 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0234 0.0235
Echinococcus multilocularis tyrosine protein kinase Blk 0.0045 0.0171 0.0172
Loa Loa (eye worm) TK protein kinase 0.0034 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0115 0.0116
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0753 0.0758
Schistosoma mansoni glycogen phosphorylase 0.0791 0.4894 0.4894
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0311 0.0311
Echinococcus multilocularis sodium and chloride dependent glycine 0.1588 0.994 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.133 0.6464
Brugia malayi Protein kinase domain containing protein 0.0148 0.0828 0.0833
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0309 0.1846 0.1846
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.0137 0.0138
Schistosoma mansoni tyrosine kinase 0.0247 0.1454 0.1454
Loa Loa (eye worm) SRC-1 0.0054 0.0234 0.0235
Echinococcus granulosus tyrosine kinase 0.0045 0.0171 0.0172
Brugia malayi protein-tyrosine kinase 0.0045 0.0171 0.0172
Toxoplasma gondii AGC kinase 0.0128 0.0702 0.3755
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0494 0.0497
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0128 0.0702 0.3755
Loa Loa (eye worm) RNA binding protein 0.0067 0.0311 0.0313
Echinococcus granulosus tyrosine protein kinase Lyn 0.0064 0.0294 0.0296
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0044 0.0167 0.0168
Loa Loa (eye worm) matrixin family protein 0.0052 0.0222 0.0223
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0171 0.0172
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0128 0.0702 0.0706
Echinococcus multilocularis sodium and chloride dependent glycine 0.1588 0.994 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.002 0.0016 0.0016
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0115 0.0523
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0035 0.0035
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0128 0.0702 0.0706
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0254 0.0504
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0234 0.0235
Loa Loa (eye worm) glutaminase 0.0287 0.1708 0.1718
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0035 0.0083
Echinococcus granulosus c src tyrosine kinase 0.0025 0.005 0.005
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0311 0.0311
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0044 0.0167 0.083
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0251 0.0252
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0015 0.0021
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0533 0.3264 0.3284
Brugia malayi Cytochrome P450 family protein 0.0028 0.0068 0.0068
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 0.0234 0.0235
Echinococcus granulosus glycogen phosphorylase 0.0791 0.4894 0.4923
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.002 0.0016 0.0016
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0128 0.0702 0.2131
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0254 0.0504
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0128 0.0702 0.0706
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0115 0.0329
Echinococcus granulosus acetylcholinesterase 0.0073 0.035 0.0352
Echinococcus granulosus tyrosine protein kinase Src42A 0.0054 0.0234 0.0235
Brugia malayi Variant SH3 domain containing protein 0.002 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0149 0.0288
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0251 0.0252
Plasmodium falciparum amino acid transporter, putative 0.0309 0.1846 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0128 0.0702 0.0706
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0309 0.1846 0.1857
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0149 0.015
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0311 0.0311
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0247 0.1454 0.1463
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0128 0.0702 0.2131
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0035 0.0132
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0494 0.0497
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0015 0.0015
Onchocerca volvulus 0.0023 0.0035 0.0047
Loa Loa (eye worm) TK/EGFR protein kinase 0.0458 0.2786 0.2803
Brugia malayi Matrixin family protein 0.0022 0.0027 0.0027
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0309 0.1846 0.1857
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0251 0.0252
Loa Loa (eye worm) TK protein kinase 0.0045 0.0171 0.0172
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0128 0.0702 0.0706
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0044 0.0167 0.083
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0035
Toxoplasma gondii kinesin motor domain-containing protein 0.0032 0.0093 0.0428
Echinococcus granulosus tyrosine protein kinase Src64B 0.0054 0.0234 0.0235
Loa Loa (eye worm) glutaminase 2 0.0287 0.1708 0.1718
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0035 0.0035
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0015 0.0033
Echinococcus multilocularis expressed conserved protein 0.009 0.0457 0.046
Loa Loa (eye worm) hypothetical protein 0.0055 0.0238 0.024
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0148 0.0828 0.0833
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0311 0.0313
Loa Loa (eye worm) methionine aminopeptidase type I 0.0044 0.0167 0.0168
Entamoeba histolytica kinesin, putative 0.0032 0.0093 0.0174
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0309 0.1846 0.1857
Onchocerca volvulus 0.0036 0.0115 0.0211
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0054 0.0234 0.0235
Onchocerca volvulus Glycogen phosphorylase homolog 0.0791 0.4894 1
Echinococcus granulosus epidermal growth factor receptor 0.0458 0.2786 0.2803
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0309 0.1846 0.1846
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0115 0.0219
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.1588 0.994 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0034 0.0108 0.0108
Echinococcus granulosus expressed conserved protein 0.009 0.0457 0.046
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0081 0.0399 0.0402
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0128 0.0702 0.2131
Echinococcus multilocularis glycogen phosphorylase 0.0791 0.4894 0.4923
Schistosoma mansoni growth factor receptor-bound protein 0.002 0.0016 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.021 0.021
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0044 0.0167 0.0487
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0008 0.0008
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0128 0.0702 0.0706
Brugia malayi RNA binding protein 0.0067 0.0311 0.0313
Echinococcus multilocularis NCK adaptor protein 0.002 0.0016 0.0016
Schistosoma mansoni tyrosine kinase 0.0025 0.005 0.005
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0058 0.0254 0.0256
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0045 0.0171 0.0172
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0115 0.0523
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0044 0.0167 0.0776
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 0.0234 0.0235
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0262 0.0262
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0044 0.0167 0.0776
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0035
Mycobacterium ulcerans hypothetical protein 0.0023 0.0035 0.0132
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0164 0.048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.021 0.021
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0044 0.0167 1
Schistosoma mansoni kinesin eg-5 0.0032 0.0093 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.021 0.021
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0035 0.0055
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0025 0.005 0.005
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0115 0.0219
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0165
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0309 0.1846 0.1846
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0068 0.0068
Schistosoma mansoni tyrosine kinase 0.0025 0.005 0.005
Schistosoma mansoni tyrosine kinase 0.0458 0.2786 0.2786
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0251 0.0251
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0054 0.0234 0.0235
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0115 0.0523
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 0.0254 0.0256
Mycobacterium ulcerans glutaminase 0.0287 0.1708 0.8313
Echinococcus granulosus protein kinase shaggy 0.0058 0.0254 0.0256
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0164 0.048
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0083 0.0229
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.0395 0.0397
Brugia malayi beta-lactamase family protein 0.0036 0.0115 0.0116
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.021 0.0211
Plasmodium falciparum glycogen synthase kinase 3 0.0058 0.0254 0.1309
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0058 0.0254 0.0757
Echinococcus multilocularis mitogen activated protein kinase 11 0.0533 0.3264 0.3284
Echinococcus granulosus tyrosine protein kinase HCK 0.0034 0.0108 0.0108
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0015 0.0021
Onchocerca volvulus 0.0022 0.0027 0.003
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0044 0.0167 0.0167
Echinococcus granulosus tyrosine protein kinase Blk 0.0045 0.0171 0.0172
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0115 0.0219
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0128 0.0702 0.0706
Mycobacterium ulcerans methionine aminopeptidase 0.0044 0.0167 0.0776
Loa Loa (eye worm) beta-lactamase 0.0036 0.0115 0.0116
Schistosoma mansoni adapter molecule crk 0.002 0.0016 0.0016
Echinococcus multilocularis acetylcholinesterase 0.0073 0.035 0.0352
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0044 0.0167 0.0168
Onchocerca volvulus 0.0047 0.0186 0.0355
Echinococcus granulosus glycogen phosphorylase 0.0791 0.4894 0.4923
Schistosoma mansoni glutaminase 0.0287 0.1708 0.1708
Echinococcus granulosus mitogen activated protein kinase 11 0.0533 0.3264 0.3284
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0262 0.1243
Schistosoma mansoni tyrosine kinase 0.0242 0.142 0.142
Brugia malayi jmjC domain containing protein 0.0057 0.0251 0.0252
Brugia malayi Kinesin motor domain containing protein 0.0032 0.0093 0.0094
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Echinococcus granulosus microtubule associated protein 2 0.1352 0.8445 0.8496
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0309 0.1846 0.1857
Echinococcus multilocularis dna polymerase eta 0.0043 0.0164 0.0165
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0044 0.0167 0.0168
Mycobacterium ulcerans hypothetical protein 0.0036 0.0115 0.0523
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0008 0.0008
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0044 0.0167 0.083
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0015 0.0014
Schistosoma mansoni patched 1 0.0041 0.0149 0.0149
Echinococcus multilocularis insulin receptor 0.0148 0.0828 0.0833
Schistosoma mansoni hypothetical protein 0.0038 0.0128 0.0128
Brugia malayi Ets-domain containing protein 0.0081 0.0399 0.0402
Echinococcus multilocularis protein kinase shaggy 0.0058 0.0254 0.0256
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0116
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0015 0.0015
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0119 0.0642 0.0646
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0035 0.0132
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0115 0.0523
Echinococcus multilocularis protein patched 0.0041 0.0149 0.015
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0015 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0702 0.0702
Schistosoma mansoni hypothetical protein 0.0047 0.0186 0.0186
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0128 0.0702 0.2131
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0128 0.0702 0.2131
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0311 0.0313
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1341 0.1349
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0068 0.0183
Echinococcus granulosus insulin receptor 0.0148 0.0828 0.0833
Mycobacterium leprae PROBABLE HYDROLASE 0.0026 0.0057 0.1649
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.021 0.0211
Leishmania major cytochrome p450-like protein 0.0028 0.0068 0.0183
Schistosoma mansoni gabp alpha 0.0081 0.0399 0.0399
Echinococcus multilocularis 0.0141 0.0781 0.0785
Mycobacterium tuberculosis Conserved protein 0.0036 0.0115 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.008 0.0395 0.0791
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.021 0.0211
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0129
Entamoeba histolytica glycogenphosphorylase, putative 0.0342 0.2053 0.4186
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0115 0.0115
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0015 0.0014
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Onchocerca volvulus 0.0036 0.0115 0.0211
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0309 0.1846 0.1857
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0309 0.1846 1
Leishmania major protein kinase A catalytic subunit isoform 2 0.0128 0.0702 0.2131
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0026 0.0057 0.0057
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0035 0.0132
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.0137 0.0138
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0702 0.0702
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0251 0.0252
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0238 0.024
Mycobacterium ulcerans beta-lactamase 0.0036 0.0115 0.0523
Brugia malayi hypothetical protein 0.0229 0.1341 0.1349
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0148 0.0828 0.0833
Onchocerca volvulus Matrilysin homolog 0.0022 0.0027 0.003
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0083 0.0371
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0128 0.0702 0.0706
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0044 0.0167 0.0487
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0035 0.0132
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0044 0.0167 0.083
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0068 0.0068
Schistosoma mansoni ap endonuclease 0.002 0.0015 0.0015
Brugia malayi SRC-1 0.0054 0.0234 0.0235
Leishmania major protein kinase A catalytic subunit isoform 1 0.0128 0.0702 0.2131
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0022 0.0027 0.0027
Trichomonas vaginalis glutaminase, putative 0.0287 0.1708 0.348
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0533 0.3264 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.0395 0.0397
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0115 0.0523
Onchocerca volvulus 0.0309 0.1846 0.3756
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0068 0.0183
Brugia malayi Matrixin family protein 0.0022 0.0027 0.0027
Entamoeba histolytica glycogen phosphorylase, putative 0.0342 0.2053 0.4186
Leishmania major DNA polymerase eta, putative 0.0043 0.0164 0.048
Loa Loa (eye worm) acetylcholinesterase 1 0.0073 0.035 0.0352
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0115 0.0115
Schistosoma mansoni tyrosine kinase 0.0247 0.1454 0.1454
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0054 0.0234 0.0235
Brugia malayi TAR-binding protein 0.0067 0.0311 0.0313
Plasmodium vivax hypothetical protein, conserved 0.0309 0.1846 1
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0044 0.0167 0.0487
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0262 0.1243
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0309 0.1846 0.1857
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 0.0254 0.0256
Entamoeba histolytica protein kinase, putative 0.002 0.0014 0.0012
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0128 0.0702 0.0706
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.4865 0.4895
Brugia malayi Matrixin family protein 0.0052 0.0222 0.0223
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0068 0.0183
Schistosoma mansoni hypothetical protein 0.008 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Entamoeba histolytica glycogen phosphorylase, putative 0.0342 0.2053 0.4186
Echinococcus granulosus NCK adaptor protein 0.002 0.0016 0.0016
Brugia malayi P38 map kinase family protein 2 0.0533 0.3264 0.3284
Toxoplasma gondii hypothetical protein 0.0309 0.1846 1
Loa Loa (eye worm) carboxylesterase 0.0073 0.035 0.0352
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0251 0.0251
Leishmania major protein kinase A catalytic subunit 0.0128 0.0702 0.2131
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0015 0.0015
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0309 0.1846 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0309 0.1846 0.1857
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0311 0.0313
Loa Loa (eye worm) hypothetical protein 0.0095 0.0494 0.0497
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0115 0.0219
Trichomonas vaginalis glycogen phosphorylase, putative 0.0791 0.4894 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0079 0.0389 0.0391
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0054 0.0234 0.0235
Loa Loa (eye worm) TK/INSR protein kinase 0.0148 0.0828 0.0833
Brugia malayi hypothetical protein 0.0309 0.1846 0.1857
Plasmodium falciparum kinesin-5 0.0032 0.0093 0.0428
Plasmodium vivax kinesin-5 0.0032 0.0093 0.0428
Brugia malayi Cytochrome P450 family protein 0.0028 0.0068 0.0068
Echinococcus multilocularis tyrosine protein kinase Srms 0.0045 0.0171 0.0172
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0342 0.2053 1
Loa Loa (eye worm) serotonin transporter b 0.0309 0.1846 0.1857
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0044 0.0167 0.0167
Brugia malayi Carboxylesterase family protein 0.0073 0.035 0.0352
Loa Loa (eye worm) sex muscle abnormal protein 5 0.002 0.0016 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0015 0.0021
Loa Loa (eye worm) AGC/PKA protein kinase 0.0128 0.0702 0.0706
Entamoeba histolytica PH domain containing protein kinase, putative 0.013 0.0711 0.1439
Schistosoma mansoni sodium/chloride dependent transporter 0.0309 0.1846 0.1846
Schistosoma mansoni growth factor receptor-bound protein 0.002 0.0016 0.0016
Entamoeba histolytica glycogen phosphorylase, putative 0.0791 0.4894 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0262 0.0264
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0311 0.0311
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0015 0.0021
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0149 0.015
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0262 0.1352
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0015 0.0014
Echinococcus multilocularis microtubule associated protein 2 0.1352 0.8445 0.8496
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0035 0.0035
Schistosoma mansoni sodium-dependent amino acid transporter 0.0309 0.1846 0.1846
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0238 0.024
Echinococcus granulosus tyrosine protein kinase Btk29A 0.016 0.0899 0.0904
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.021 0.0211
Loa Loa (eye worm) hypothetical protein 0.0073 0.035 0.0352
Schistosoma mansoni hypothetical protein 0.0039 0.014 0.014
Schistosoma mansoni tyrosine kinase 0.0242 0.142 0.142
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0309 0.1846 0.1857
Giardia lamblia Glycogen phosphorylase 0.0791 0.4894 1
Brugia malayi Matrixin family protein 0.0022 0.0027 0.0027
Giardia lamblia Kinase, AGC PKA 0.0128 0.0702 0.1421
Brugia malayi Sex muscle abnormal protein 5 0.002 0.0016 0.0016
Treponema pallidum sodium- and chloride- dependent transporter 0.0309 0.1846 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0035 0.0132
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0079 0.0389 0.0391
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0309 0.1846 0.1846
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0309 0.1846 0.1846
Trypanosoma brucei protein kinase, putative 0.0058 0.0254 0.0757
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0128 0.0702 0.3755
Echinococcus multilocularis geminin 0.0376 0.2268 0.2282
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0116
Loa Loa (eye worm) norepinephrine transporter 0.0309 0.1846 0.1857
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0115 0.0329
Echinococcus granulosus sodium and chloride dependent glycine 0.1588 0.994 1
Trichomonas vaginalis esterase, putative 0.0036 0.0115 0.0219
Schistosoma mansoni ap endonuclease 0.002 0.0015 0.0015
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 0.0234 0.0235
Echinococcus multilocularis mitogen activated protein kinase 14 0.0533 0.3264 0.3284
Echinococcus granulosus serotonin transporter 0.0309 0.1846 0.1857
Echinococcus granulosus acetylcholinesterase 0.0073 0.035 0.0352
Schistosoma mansoni microtubule-associated protein tau 0.1352 0.8445 0.8445
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0309 0.1846 0.3552
Schistosoma mansoni hypothetical protein 0.0376 0.2268 0.2268
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0016
Toxoplasma gondii hypothetical protein 0.0309 0.1846 1
Schistosoma mansoni hypothetical protein 0.0215 0.1252 0.1252
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0027
Brugia malayi Hemopexin family protein 0.0031 0.0084 0.0085
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0115 0.0523
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0262 0.078
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0054 0.0234 0.0235
Echinococcus multilocularis protein dispatched 1 0.0047 0.0186 0.0187
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0309 0.1846 0.1846
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0311 0.0313
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.021 0.0211
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0035 0.0132
Onchocerca volvulus Matrix metalloproteinase homolog 0.0048 0.0194 0.0373
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0309 0.1846 0.1857
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0503 0.0503
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0309 0.1846 0.1846
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0068 0.0068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.021 0.0211
Echinococcus multilocularis tyrosine protein kinase Abl 0.0025 0.005 0.005
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0058 0.0254 0.0256
Echinococcus multilocularis mitogen activated protein kinase 11 0.0533 0.3264 0.3284
Echinococcus granulosus growth factor receptor bound protein 2 0.002 0.0016 0.0016
Toxoplasma gondii AGC kinase 0.0128 0.0702 0.3755
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0115 0.0548
Trichomonas vaginalis AGC family protein kinase 0.0128 0.0702 0.1421
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0058 0.0254 0.0757
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0115 0.0329
Schistosoma mansoni transcription factor LCR-F1 0.008 0.0395 0.0395
Giardia lamblia Kinesin-5 0.0032 0.0093 0.0174
Brugia malayi carbohydrate phosphorylase 0.0791 0.4894 0.4923
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0073 0.035 0.035
Echinococcus multilocularis kinesin family 1 0.0247 0.1456 0.1464
Echinococcus granulosus Glycosyl transferase family 35 0.0791 0.4894 0.4923
Leishmania major DNA polymerase eta, putative 0.0031 0.0083 0.0229
Loa Loa (eye worm) matrixin family protein 0.0048 0.0194 0.0195
Chlamydia trachomatis glycogen phosphorylase 0.0791 0.4894 1
Echinococcus granulosus epidermal growth factor receptor 0.0247 0.1454 0.1463
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0119 0.0642 0.0646
Echinococcus multilocularis mitogen activated protein kinase 14 0.0533 0.3264 0.3284
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0251 0.0252
Loa Loa (eye worm) variant SH3 domain-containing protein 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.1588 0.994 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0207 0.0208
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0116
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.016 0.0899 0.0904
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0254 0.0504
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0035 0.0083
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0068 0.0291
Schistosoma mansoni DNA polymerase eta 0.0043 0.0164 0.0164
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0035 0.0132
Plasmodium vivax glycogen synthase kinase 3, putative 0.0058 0.0254 0.1309
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0044 0.0167 0.083
Loa Loa (eye worm) hypothetical protein 0.0041 0.0149 0.015
Brugia malayi Ets-domain containing protein 0.0081 0.0399 0.0402
Schistosoma mansoni glycogen phosphorylase 0.0342 0.2053 0.2053
Echinococcus granulosus kinesin family 1 0.0247 0.1456 0.1464
Brugia malayi Carboxylesterase family protein 0.0073 0.035 0.0352
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0084
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0115 0.0523
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0342 0.2053 1
Schistosoma mansoni tyrosine kinase 0.0054 0.0234 0.0234
Onchocerca volvulus 0.0309 0.1846 0.3756
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0533 0.3264 1
Leishmania major hypothetical protein, conserved 0.0036 0.0115 0.0329
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0262 0.1243
Mycobacterium tuberculosis Conserved protein 0.0036 0.0115 0.0523
Toxoplasma gondii ABC1 family protein 0.0036 0.0115 0.0548
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0533 0.3264 1
Loa Loa (eye worm) glycogen phosphorylase 0.0791 0.4894 0.4923
Loa Loa (eye worm) fli-1 protein 0.0245 0.1437 0.1446
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0026 0.0057 0.0238
Entamoeba histolytica hypothetical protein 0.008 0.0395 0.0791
Brugia malayi beta-lactamase 0.0036 0.0115 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.0229 0.1341 0.1349
Entamoeba histolytica hypothetical protein 0.008 0.0395 0.0791
Echinococcus granulosus GA binding protein alpha chain 0.0081 0.0399 0.0402
Brugia malayi jmjC domain containing protein 0.0057 0.0251 0.0252
Mycobacterium ulcerans hydrolase 0.0026 0.0057 0.0238
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0054 0.0234 0.0235
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0008 0.0008
Schistosoma mansoni tyrosine kinase 0.015 0.0837 0.0837
Brugia malayi Furin-like cysteine rich region family protein 0.0458 0.2786 0.2803
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0186 0.0187
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0054 0.0234 0.0235
Schistosoma mansoni hypothetical protein 0.0039 0.014 0.014
Plasmodium falciparum transporter, putative 0.0309 0.1846 1
Brugia malayi beta-lactamase family protein 0.0036 0.0115 0.0116
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0309 0.1846 0.1857
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0116
Brugia malayi hypothetical protein 0.008 0.0395 0.0397
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0035 0.0055
Echinococcus multilocularis GA binding protein alpha chain 0.0081 0.0399 0.0402
Entamoeba histolytica SH2-protein kinase domain containing protein 0.002 0.0014 0.0012
Schistosoma mansoni hypothetical protein 0.0039 0.014 0.014
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0015 0.0014
Brugia malayi intracellular kinase 0.0058 0.0254 0.0256
Onchocerca volvulus Matrilysin homolog 0.0048 0.0194 0.0373
Brugia malayi Variant SH3 domain containing protein 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0115 0.0116
Toxoplasma gondii methionine aminopeptidase 0.0044 0.0167 0.083
Schistosoma mansoni nck2/grb4 0.002 0.0016 0.0016
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0044 0.0167 0.0776
Schistosoma mansoni sodium/chloride dependent transporter 0.1588 0.994 0.994
Entamoeba histolytica protein kinase, putative 0.0034 0.0108 0.0204
Loa Loa (eye worm) AGC/PKA protein kinase 0.0128 0.0702 0.0706
Giardia lamblia Kinase, CMGC GSK 0.0058 0.0254 0.0504
Brugia malayi Methionine aminopeptidase protein type I 0.0044 0.0167 0.0168
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0115 0.0523
Onchocerca volvulus 0.0036 0.0115 0.0211
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0234 0.0235
Echinococcus granulosus dna polymerase eta 0.0043 0.0164 0.0165
Echinococcus granulosus geminin 0.0376 0.2268 0.2282
Echinococcus multilocularis glycogen phosphorylase 0.0791 0.4894 0.4923
Mycobacterium leprae Probable lipase LipE 0.0036 0.0115 0.608
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0149 0.015
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0115 0.608
Entamoeba histolytica hypothetical protein 0.008 0.0395 0.0791
Echinococcus granulosus dna polymerase kappa 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Entamoeba histolytica PH domain containing protein kinase, putative 0.013 0.0711 0.1439
Schistosoma mansoni hypothetical protein 0.0039 0.014 0.014
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0494 0.0497
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0035 0.0132
Echinococcus multilocularis epidermal growth factor receptor 0.0247 0.1454 0.1463
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0238 0.024
Onchocerca volvulus 0.0309 0.1846 0.3756
Brugia malayi glutaminase DH11.1 0.0287 0.1708 0.1718
Treponema pallidum methionine aminopeptidase (map) 0.0044 0.0167 0.083
Schistosoma mansoni glycogen phosphorylase 0.0791 0.4894 0.4894
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0128 0.0702 0.3755
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0128 0.0129
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0115 0.0219
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0116
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0035

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 0.1 uM Inhibition of KSP in A549 cells assessed by MPM-2 cytoblot assay ChEMBL. 17498954
EC50 (binding) = 0.1 uM Inhibition of KSP in A549 cells assessed by MPM-2 cytoblot assay ChEMBL. 17498954
EC50 (functional) = 1 uM Cytotoxicity against A549 cells after 60 hrs ChEMBL. 17498954
EC50 (functional) = 1 uM Cytotoxicity against A549 cells after 60 hrs ChEMBL. 17498954
IC50 (binding) = 0.48 uM Inhibition of human KSP expressed in Escherichia coli assessed by ATPase assay ChEMBL. 17498954
IC50 (binding) = 0.48 uM Inhibition of human KSP expressed in Escherichia coli assessed by ATPase assay ChEMBL. 17498954

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17498954

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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