Detailed information for compound 430740

Basic information

Technical information
  • TDR Targets ID: 430740
  • Name: N,N-diethyl-5,5-dimethyl-2-(thiophene-2-carbo nylamino)-6,7-dihydro-4H-1-benzothiophene-3-c arboxamide
  • MW: 390.563 | Formula: C20H26N2O2S2
  • H donors: 1 H acceptors: 2 LogP: 5.41 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1c(NC(=O)c2cccs2)sc2c1CC(C)(C)CC2)CC
  • InChi: 1S/C20H26N2O2S2/c1-5-22(6-2)19(24)16-13-12-20(3,4)10-9-14(13)26-18(16)21-17(23)15-8-7-11-25-15/h7-8,11H,5-6,9-10,12H2,1-4H3,(H,21,23)
  • InChiKey: BCQPPORYBRTCLZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N-diethyl-5,5-dimethyl-2-(thiophene-2-carbonylamino)-6,7-dihydro-4H-benzothiophene-3-carboxamide
  • N,N-diethyl-5,5-dimethyl-2-[[oxo(2-thienyl)methyl]amino]-6,7-dihydro-4H-benzothiophene-3-carboxamide
  • N,N-diethyl-5,5-dimethyl-2-(thiophen-2-ylcarbonylamino)-6,7-dihydro-4H-1-benzothiophene-3-carboxamide
  • N,N-diethyl-5,5-dimethyl-2-(2-thenoylamino)-6,7-dihydro-4H-benzothiophene-3-carboxamide
  • N,N-diethyl-5,5-dimethyl-2-[[oxo-(2-thienyl)methyl]amino]-6,7-dihydro-4H-benzothiophene-3-carboxamide
  • K03

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinesin family member 11 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis kinesin-like boursin Get druggable targets OG5_128460 All targets in OG5_128460
Candida albicans kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium knowlesi kinesin-5, putative Get druggable targets OG5_128460 All targets in OG5_128460
Entamoeba histolytica kinesin, putative Get druggable targets OG5_128460 All targets in OG5_128460
Giardia lamblia Kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Cryptosporidium parvum kinesin-like boursin, putative Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium falciparum kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Loa Loa (eye worm) kinesin-like protein KLP2 Get druggable targets OG5_128460 All targets in OG5_128460
Echinococcus granulosus kinesin family 1 Get druggable targets OG5_128460 All targets in OG5_128460
Neospora caninum hypothetical protein Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium vivax kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Schistosoma japonicum ko:K10398 kinesin family member 11, putative Get druggable targets OG5_128460 All targets in OG5_128460
Schistosoma mansoni kinesin eg-5 Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium yoelii Kinesin motor domain, putative Get druggable targets OG5_128460 All targets in OG5_128460
Brugia malayi Kinesin motor domain containing protein Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium berghei kinesin-5, putative Get druggable targets OG5_128460 All targets in OG5_128460
Echinococcus multilocularis kinesin family 1 Get druggable targets OG5_128460 All targets in OG5_128460
Toxoplasma gondii kinesin motor domain-containing protein Get druggable targets OG5_128460 All targets in OG5_128460
Candida albicans kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein Get druggable targets OG5_128460 All targets in OG5_128460
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0309 0.1846 0.1846
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0128 0.0702 0.2131
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0058 0.0254 0.1309
Echinococcus granulosus tar DNA binding protein 0.0067 0.0311 0.0313
Loa Loa (eye worm) hypothetical protein 0.0073 0.035 0.0352
Echinococcus multilocularis carboxylesterase 5A 0.0073 0.035 0.0352
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0115 0.0116
Brugia malayi Fli-1 protein 0.0245 0.1437 0.1446
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1341 0.1349
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0254 0.0504
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0164 0.0165
Onchocerca volvulus 0.0309 0.1846 0.3756
Loa Loa (eye worm) kinesin-like protein KLP2 0.0032 0.0093 0.0094
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0027
Brugia malayi Tyrosine-protein kinase abl-1 0.0025 0.005 0.005
Entamoeba histolytica glycogen phosphorylase, putative 0.0791 0.4894 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0533 0.3264 1
Schistosoma mansoni ets-related 0.0245 0.1437 0.1437
Mycobacterium tuberculosis Conserved protein 0.0036 0.0115 0.0523
Echinococcus multilocularis c src tyrosine kinase 0.0025 0.005 0.005
Trypanosoma brucei methionine aminopeptidase, putative 0.0044 0.0167 0.0487
Schistosoma mansoni tyrosine kinase 0.0054 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0027
Plasmodium vivax amine transporter, putative 0.0309 0.1846 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0008 0.0008
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0044 0.0167 0.0487
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0008 0.0008
Onchocerca volvulus 0.0058 0.0254 0.0496
Echinococcus granulosus carboxylesterase 5A 0.0073 0.035 0.0352
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0251 0.0251
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0494 0.0994
Echinococcus granulosus mitogen activated protein kinase 14 0.0533 0.3264 0.3284
Entamoeba histolytica protein kinase, putative 0.0058 0.0254 0.0504
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0309 0.1846 0.1857
Echinococcus multilocularis epidermal growth factor receptor 0.0458 0.2786 0.2803
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0309 0.1846 0.1846
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0309 0.1846 0.1857
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0309 0.1846 0.1857
Trichomonas vaginalis glycogen phosphorylase, putative 0.0791 0.4894 1
Schistosoma mansoni tyrosine kinase 0.0148 0.0828 0.0828
Schistosoma mansoni tyrosine kinase 0.0242 0.142 0.142
Loa Loa (eye worm) matrix metalloproteinase 0.0022 0.0027 0.0027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0035 0.0055
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0044 0.0167 1
Echinococcus multilocularis Glycosyl transferase, family 35 0.0791 0.4894 0.4923
Loa Loa (eye worm) hypothetical protein 0.0069 0.0326 0.0327
Brugia malayi Matrixin family protein 0.0022 0.0027 0.0027
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0044 0.0167 1
Echinococcus granulosus sodium and chloride dependent glycine 0.1588 0.994 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0054 0.0234 0.0235
Echinococcus multilocularis acetylcholinesterase 0.0073 0.035 0.0352
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1588 0.994 1
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0128 0.0702 0.2131
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0116
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0262 0.0262
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0008 0.0008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0262 0.1243
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0753 0.0758
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0035 0.0132
Mycobacterium ulcerans lipase LipD 0.0036 0.0115 0.0523
Schistosoma mansoni tyrosine kinase 0.0148 0.0828 0.0828
Giardia lamblia Kinase, CMGC GSK 0.0058 0.0254 0.0504
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0044 0.0167 0.0487
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0035 0.0035
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0128 0.0702 0.0706
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0234 0.0235
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0254 0.0504
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0035 0.0083
Loa Loa (eye worm) glutaminase 0.0287 0.1708 0.1718
Echinococcus granulosus c src tyrosine kinase 0.0025 0.005 0.005
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0311 0.0311
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0044 0.0167 0.083
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0015 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0251 0.0252
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0533 0.3264 0.3284
Echinococcus granulosus glycogen phosphorylase 0.0791 0.4894 0.4923
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.002 0.0016 0.0016
Brugia malayi Cytochrome P450 family protein 0.0028 0.0068 0.0068
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 0.0234 0.0235
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0128 0.0702 0.2131
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0128 0.0702 0.0706
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0254 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0149 0.0288
Echinococcus granulosus acetylcholinesterase 0.0073 0.035 0.0352
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0115 0.0329
Brugia malayi Variant SH3 domain containing protein 0.002 0.0016 0.0016
Echinococcus granulosus tyrosine protein kinase Src42A 0.0054 0.0234 0.0235
Plasmodium falciparum amino acid transporter, putative 0.0309 0.1846 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0251 0.0252
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0311 0.0311
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0128 0.0702 0.0706
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0149 0.015
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0309 0.1846 0.1857
Brugia malayi CHE-14 protein 0.0041 0.0149 0.015
Onchocerca volvulus 0.0031 0.0084 0.0148
Schistosoma mansoni hypothetical protein 0.0376 0.2268 0.2268
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0115 0.0116
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0262 0.0264
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0311 0.0311
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0149 0.015
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0058 0.0254 0.0254
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0035 0.0083
Echinococcus multilocularis serotonin transporter 0.0309 0.1846 0.1857
Toxoplasma gondii methionine aminopeptidase 0.0044 0.0167 0.083
Loa Loa (eye worm) hypothetical protein 0.1588 0.994 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0234 0.0235
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0115 0.0523
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0309 0.1846 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0186 0.0186
Echinococcus multilocularis tyrosine protein kinase Blk 0.0045 0.0171 0.0172
Loa Loa (eye worm) TK protein kinase 0.0034 0.0108 0.0108
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0753 0.0758
Schistosoma mansoni glycogen phosphorylase 0.0791 0.4894 0.4894
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0115 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0311 0.0311
Echinococcus multilocularis sodium and chloride dependent glycine 0.1588 0.994 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.133 0.6464
Brugia malayi Protein kinase domain containing protein 0.0148 0.0828 0.0833
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0309 0.1846 0.1846
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.0137 0.0138
Schistosoma mansoni tyrosine kinase 0.0247 0.1454 0.1454
Loa Loa (eye worm) SRC-1 0.0054 0.0234 0.0235
Echinococcus granulosus tyrosine kinase 0.0045 0.0171 0.0172
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0128 0.0702 0.3755
Loa Loa (eye worm) RNA binding protein 0.0067 0.0311 0.0313
Brugia malayi protein-tyrosine kinase 0.0045 0.0171 0.0172
Toxoplasma gondii AGC kinase 0.0128 0.0702 0.3755
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0494 0.0497
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0044 0.0167 0.0168
Echinococcus granulosus tyrosine protein kinase Lyn 0.0064 0.0294 0.0296
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0128 0.0702 0.0706
Loa Loa (eye worm) matrixin family protein 0.0052 0.0222 0.0223
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0171 0.0172
Echinococcus multilocularis sodium and chloride dependent glycine 0.1588 0.994 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.002 0.0016 0.0016
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0115 0.0523
Echinococcus granulosus expressed conserved protein 0.009 0.0457 0.046
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0081 0.0399 0.0402
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0128 0.0702 0.2131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.021 0.021
Echinococcus multilocularis glycogen phosphorylase 0.0791 0.4894 0.4923
Schistosoma mansoni growth factor receptor-bound protein 0.002 0.0016 0.0016
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0008 0.0008
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0044 0.0167 0.0487
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0128 0.0702 0.0706
Brugia malayi RNA binding protein 0.0067 0.0311 0.0313
Schistosoma mansoni tyrosine kinase 0.0025 0.005 0.005
Echinococcus multilocularis NCK adaptor protein 0.002 0.0016 0.0016
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0045 0.0171 0.0172
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0058 0.0254 0.0256
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0044 0.0167 0.0776
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 0.0234 0.0235
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0115 0.0523
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0044 0.0167 0.0776
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0035
Mycobacterium ulcerans hypothetical protein 0.0023 0.0035 0.0132
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0164 0.048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.021 0.021
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0044 0.0167 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0035 0.0055
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0115 0.0219
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0025 0.005 0.005
Schistosoma mansoni kinesin eg-5 0.0032 0.0093 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.021 0.021
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0309 0.1846 0.1846
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0165
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0068 0.0068
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0247 0.1454 0.1463
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0128 0.0702 0.2131
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0494 0.0497
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0035 0.0132
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0251 0.0252
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0309 0.1846 0.1857
Loa Loa (eye worm) TK protein kinase 0.0045 0.0171 0.0172
Onchocerca volvulus 0.0023 0.0035 0.0047
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0015 0.0015
Brugia malayi Matrixin family protein 0.0022 0.0027 0.0027
Loa Loa (eye worm) TK/EGFR protein kinase 0.0458 0.2786 0.2803
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0044 0.0167 0.083
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0128 0.0702 0.0706
Echinococcus granulosus tyrosine protein kinase Src64B 0.0054 0.0234 0.0235
Toxoplasma gondii kinesin motor domain-containing protein 0.0032 0.0093 0.0428
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0035 0.0035
Loa Loa (eye worm) glutaminase 2 0.0287 0.1708 0.1718
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0015 0.0033
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0311 0.0313
Loa Loa (eye worm) hypothetical protein 0.0055 0.0238 0.024
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0148 0.0828 0.0833
Echinococcus multilocularis expressed conserved protein 0.009 0.0457 0.046
Entamoeba histolytica kinesin, putative 0.0032 0.0093 0.0174
Loa Loa (eye worm) methionine aminopeptidase type I 0.0044 0.0167 0.0168
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0309 0.1846 0.1857
Onchocerca volvulus 0.0036 0.0115 0.0211
Echinococcus granulosus epidermal growth factor receptor 0.0458 0.2786 0.2803
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0309 0.1846 0.1846
Onchocerca volvulus Glycogen phosphorylase homolog 0.0791 0.4894 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0054 0.0234 0.0235
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0115 0.0219
Echinococcus multilocularis tyrosine protein kinase HCK 0.0034 0.0108 0.0108
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.1588 0.994 1
Echinococcus multilocularis acetylcholinesterase 0.0073 0.035 0.0352
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0044 0.0167 0.0168
Onchocerca volvulus 0.0047 0.0186 0.0355
Echinococcus granulosus glycogen phosphorylase 0.0791 0.4894 0.4923
Echinococcus granulosus mitogen activated protein kinase 11 0.0533 0.3264 0.3284
Schistosoma mansoni glutaminase 0.0287 0.1708 0.1708
Brugia malayi Kinesin motor domain containing protein 0.0032 0.0093 0.0094
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Echinococcus granulosus microtubule associated protein 2 0.1352 0.8445 0.8496
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0262 0.1243
Schistosoma mansoni tyrosine kinase 0.0242 0.142 0.142
Brugia malayi jmjC domain containing protein 0.0057 0.0251 0.0252
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0309 0.1846 0.1857
Mycobacterium ulcerans hypothetical protein 0.0036 0.0115 0.0523
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0044 0.0167 0.083
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0008 0.0008
Echinococcus multilocularis dna polymerase eta 0.0043 0.0164 0.0165
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0044 0.0167 0.0168
Echinococcus multilocularis insulin receptor 0.0148 0.0828 0.0833
Schistosoma mansoni patched 1 0.0041 0.0149 0.0149
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0015 0.0014
Schistosoma mansoni hypothetical protein 0.0038 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0116
Brugia malayi Ets-domain containing protein 0.0081 0.0399 0.0402
Echinococcus multilocularis protein kinase shaggy 0.0058 0.0254 0.0256
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0035 0.0132
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0115 0.0523
Echinococcus multilocularis protein patched 0.0041 0.0149 0.015
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0015 0.0015
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0119 0.0642 0.0646
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0702 0.0702
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0015 0.0033
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0128 0.0702 0.2131
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0128 0.0702 0.2131
Schistosoma mansoni hypothetical protein 0.0047 0.0186 0.0186
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0311 0.0313
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1341 0.1349
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0068 0.0183
Echinococcus granulosus insulin receptor 0.0148 0.0828 0.0833
Mycobacterium leprae PROBABLE HYDROLASE 0.0026 0.0057 0.1649
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.021 0.0211
Leishmania major cytochrome p450-like protein 0.0028 0.0068 0.0183
Schistosoma mansoni tyrosine kinase 0.0025 0.005 0.005
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 0.0254 0.0256
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0251 0.0251
Schistosoma mansoni tyrosine kinase 0.0458 0.2786 0.2786
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0054 0.0234 0.0235
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0115 0.0523
Mycobacterium ulcerans glutaminase 0.0287 0.1708 0.8313
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0164 0.048
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0083 0.0229
Echinococcus granulosus protein kinase shaggy 0.0058 0.0254 0.0256
Brugia malayi beta-lactamase family protein 0.0036 0.0115 0.0116
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.0395 0.0397
Plasmodium falciparum glycogen synthase kinase 3 0.0058 0.0254 0.1309
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.021 0.0211
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0058 0.0254 0.0757
Echinococcus granulosus tyrosine protein kinase HCK 0.0034 0.0108 0.0108
Echinococcus multilocularis mitogen activated protein kinase 11 0.0533 0.3264 0.3284
Onchocerca volvulus 0.0022 0.0027 0.003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0015 0.0021
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0044 0.0167 0.0167
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0115 0.0219
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0128 0.0702 0.0706
Echinococcus granulosus tyrosine protein kinase Blk 0.0045 0.0171 0.0172
Loa Loa (eye worm) beta-lactamase 0.0036 0.0115 0.0116
Mycobacterium ulcerans methionine aminopeptidase 0.0044 0.0167 0.0776
Schistosoma mansoni adapter molecule crk 0.002 0.0016 0.0016
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0044 0.0167 0.0487
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0035 0.0132
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0128 0.0702 0.0706
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0044 0.0167 0.083
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0068 0.0068
Leishmania major protein kinase A catalytic subunit isoform 1 0.0128 0.0702 0.2131
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0022 0.0027 0.0027
Schistosoma mansoni ap endonuclease 0.002 0.0015 0.0015
Brugia malayi SRC-1 0.0054 0.0234 0.0235
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.0395 0.0397
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0115 0.0523
Trichomonas vaginalis glutaminase, putative 0.0287 0.1708 0.348
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0533 0.3264 1
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0068 0.0183
Onchocerca volvulus 0.0309 0.1846 0.3756
Brugia malayi Matrixin family protein 0.0022 0.0027 0.0027
Entamoeba histolytica glycogen phosphorylase, putative 0.0342 0.2053 0.4186
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0115 0.0115
Schistosoma mansoni tyrosine kinase 0.0247 0.1454 0.1454
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0054 0.0234 0.0235
Leishmania major DNA polymerase eta, putative 0.0043 0.0164 0.048
Loa Loa (eye worm) acetylcholinesterase 1 0.0073 0.035 0.0352
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0044 0.0167 0.0487
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0309 0.1846 0.1857
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0262 0.1243
Brugia malayi TAR-binding protein 0.0067 0.0311 0.0313
Plasmodium vivax hypothetical protein, conserved 0.0309 0.1846 1
Entamoeba histolytica protein kinase, putative 0.002 0.0014 0.0012
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 0.0254 0.0256
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0068 0.0183
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0128 0.0702 0.0706
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.4865 0.4895
Brugia malayi Matrixin family protein 0.0052 0.0222 0.0223
Schistosoma mansoni hypothetical protein 0.008 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Brugia malayi P38 map kinase family protein 2 0.0533 0.3264 0.3284
Echinococcus granulosus NCK adaptor protein 0.002 0.0016 0.0016
Entamoeba histolytica glycogen phosphorylase, putative 0.0342 0.2053 0.4186
Loa Loa (eye worm) carboxylesterase 0.0073 0.035 0.0352
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0251 0.0251
Toxoplasma gondii hypothetical protein 0.0309 0.1846 1
Echinococcus multilocularis 0.0141 0.0781 0.0785
Schistosoma mansoni gabp alpha 0.0081 0.0399 0.0399
Mycobacterium tuberculosis Conserved protein 0.0036 0.0115 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.008 0.0395 0.0791
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.021 0.0211
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0129
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0115 0.0115
Entamoeba histolytica glycogenphosphorylase, putative 0.0342 0.2053 0.4186
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0015 0.0014
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0015 0.0015
Onchocerca volvulus 0.0036 0.0115 0.0211
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0309 0.1846 0.1857
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0309 0.1846 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0026 0.0057 0.0057
Leishmania major protein kinase A catalytic subunit isoform 2 0.0128 0.0702 0.2131
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0251 0.0252
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0035 0.0132
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.0137 0.0138
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0702 0.0702
Brugia malayi hypothetical protein 0.0229 0.1341 0.1349
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0148 0.0828 0.0833
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0238 0.024
Mycobacterium ulcerans beta-lactamase 0.0036 0.0115 0.0523
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0083 0.0371
Onchocerca volvulus Matrilysin homolog 0.0022 0.0027 0.003
Loa Loa (eye worm) hypothetical protein 0.0073 0.035 0.0352
Giardia lamblia Glycogen phosphorylase 0.0791 0.4894 1
Brugia malayi Matrixin family protein 0.0022 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0039 0.014 0.014
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0309 0.1846 0.1857
Schistosoma mansoni tyrosine kinase 0.0242 0.142 0.142
Brugia malayi Sex muscle abnormal protein 5 0.002 0.0016 0.0016
Giardia lamblia Kinase, AGC PKA 0.0128 0.0702 0.1421
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0079 0.0389 0.0391
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0035 0.0132
Treponema pallidum sodium- and chloride- dependent transporter 0.0309 0.1846 1
Loa Loa (eye worm) norepinephrine transporter 0.0309 0.1846 0.1857
Trypanosoma brucei protein kinase, putative 0.0058 0.0254 0.0757
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0309 0.1846 0.1846
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0309 0.1846 0.1846
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0128 0.0702 0.3755
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0116
Echinococcus multilocularis geminin 0.0376 0.2268 0.2282
Trichomonas vaginalis esterase, putative 0.0036 0.0115 0.0219
Echinococcus granulosus sodium and chloride dependent glycine 0.1588 0.994 1
Schistosoma mansoni ap endonuclease 0.002 0.0015 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0115 0.0329
Echinococcus multilocularis mitogen activated protein kinase 14 0.0533 0.3264 0.3284
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 0.0234 0.0235
Echinococcus granulosus acetylcholinesterase 0.0073 0.035 0.0352
Echinococcus granulosus serotonin transporter 0.0309 0.1846 0.1857
Schistosoma mansoni microtubule-associated protein tau 0.1352 0.8445 0.8445
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0309 0.1846 0.3552
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0376 0.2268 0.2268
Toxoplasma gondii hypothetical protein 0.0309 0.1846 1
Brugia malayi Hemopexin family protein 0.0031 0.0084 0.0085
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0115 0.0523
Schistosoma mansoni hypothetical protein 0.0215 0.1252 0.1252
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0027
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0054 0.0234 0.0235
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0262 0.078
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0309 0.1846 0.1846
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0311 0.0313
Echinococcus multilocularis protein dispatched 1 0.0047 0.0186 0.0187
Leishmania major protein kinase A catalytic subunit 0.0128 0.0702 0.2131
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0015 0.0015
Loa Loa (eye worm) solute carrier family 6 member 4 0.0309 0.1846 0.1857
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0309 0.1846 1
Trichomonas vaginalis glycogen phosphorylase, putative 0.0791 0.4894 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0079 0.0389 0.0391
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0311 0.0313
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0115 0.0219
Loa Loa (eye worm) hypothetical protein 0.0095 0.0494 0.0497
Loa Loa (eye worm) TK/INSR protein kinase 0.0148 0.0828 0.0833
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0054 0.0234 0.0235
Brugia malayi Cytochrome P450 family protein 0.0028 0.0068 0.0068
Brugia malayi hypothetical protein 0.0309 0.1846 0.1857
Plasmodium falciparum kinesin-5 0.0032 0.0093 0.0428
Plasmodium vivax kinesin-5 0.0032 0.0093 0.0428
Echinococcus multilocularis tyrosine protein kinase Srms 0.0045 0.0171 0.0172
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0342 0.2053 1
Brugia malayi Carboxylesterase family protein 0.0073 0.035 0.0352
Loa Loa (eye worm) serotonin transporter b 0.0309 0.1846 0.1857
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0044 0.0167 0.0167
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0015 0.0021
Loa Loa (eye worm) AGC/PKA protein kinase 0.0128 0.0702 0.0706
Loa Loa (eye worm) sex muscle abnormal protein 5 0.002 0.0016 0.0016
Schistosoma mansoni sodium/chloride dependent transporter 0.0309 0.1846 0.1846
Entamoeba histolytica PH domain containing protein kinase, putative 0.013 0.0711 0.1439
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0262 0.0264
Schistosoma mansoni growth factor receptor-bound protein 0.002 0.0016 0.0016
Entamoeba histolytica glycogen phosphorylase, putative 0.0791 0.4894 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0311 0.0311
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0015 0.0014
Echinococcus multilocularis microtubule associated protein 2 0.1352 0.8445 0.8496
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0035 0.0035
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0149 0.015
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0015 0.0021
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0262 0.1352
Schistosoma mansoni sodium-dependent amino acid transporter 0.0309 0.1846 0.1846
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0238 0.024
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.021 0.0211
Echinococcus granulosus tyrosine protein kinase Btk29A 0.016 0.0899 0.0904
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Schistosoma mansoni DNA polymerase eta 0.0043 0.0164 0.0164
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0035 0.0083
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0068 0.0291
Plasmodium vivax glycogen synthase kinase 3, putative 0.0058 0.0254 0.1309
Loa Loa (eye worm) hypothetical protein 0.0041 0.0149 0.015
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0044 0.0167 0.083
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0035 0.0132
Brugia malayi Carboxylesterase family protein 0.0073 0.035 0.0352
Echinococcus granulosus kinesin family 1 0.0247 0.1456 0.1464
Brugia malayi Ets-domain containing protein 0.0081 0.0399 0.0402
Schistosoma mansoni glycogen phosphorylase 0.0342 0.2053 0.2053
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0084
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0115 0.0523
Schistosoma mansoni tyrosine kinase 0.0054 0.0234 0.0234
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0342 0.2053 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0533 0.3264 1
Onchocerca volvulus 0.0309 0.1846 0.3756
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Leishmania major hypothetical protein, conserved 0.0036 0.0115 0.0329
Mycobacterium tuberculosis Conserved protein 0.0036 0.0115 0.0523
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0262 0.1243
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0533 0.3264 1
Toxoplasma gondii ABC1 family protein 0.0036 0.0115 0.0548
Loa Loa (eye worm) glycogen phosphorylase 0.0791 0.4894 0.4923
Loa Loa (eye worm) fli-1 protein 0.0245 0.1437 0.1446
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0026 0.0057 0.0238
Entamoeba histolytica hypothetical protein 0.008 0.0395 0.0791
Brugia malayi beta-lactamase 0.0036 0.0115 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0702 0.0702
Entamoeba histolytica hypothetical protein 0.008 0.0395 0.0791
Loa Loa (eye worm) hypothetical protein 0.0229 0.1341 0.1349
Onchocerca volvulus Matrix metalloproteinase homolog 0.0048 0.0194 0.0373
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.021 0.0211
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0035 0.0132
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0309 0.1846 0.1857
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0503 0.0503
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0068 0.0068
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0309 0.1846 0.1846
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0058 0.0254 0.0256
Echinococcus multilocularis mitogen activated protein kinase 11 0.0533 0.3264 0.3284
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.021 0.0211
Echinococcus multilocularis tyrosine protein kinase Abl 0.0025 0.005 0.005
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0115 0.0548
Trichomonas vaginalis AGC family protein kinase 0.0128 0.0702 0.1421
Echinococcus granulosus growth factor receptor bound protein 2 0.002 0.0016 0.0016
Toxoplasma gondii AGC kinase 0.0128 0.0702 0.3755
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0115 0.0329
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0058 0.0254 0.0757
Brugia malayi carbohydrate phosphorylase 0.0791 0.4894 0.4923
Schistosoma mansoni transcription factor LCR-F1 0.008 0.0395 0.0395
Giardia lamblia Kinesin-5 0.0032 0.0093 0.0174
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0073 0.035 0.035
Echinococcus multilocularis kinesin family 1 0.0247 0.1456 0.1464
Echinococcus granulosus Glycosyl transferase family 35 0.0791 0.4894 0.4923
Chlamydia trachomatis glycogen phosphorylase 0.0791 0.4894 1
Loa Loa (eye worm) matrixin family protein 0.0048 0.0194 0.0195
Leishmania major DNA polymerase eta, putative 0.0031 0.0083 0.0229
Echinococcus multilocularis mitogen activated protein kinase 14 0.0533 0.3264 0.3284
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0251 0.0252
Echinococcus granulosus epidermal growth factor receptor 0.0247 0.1454 0.1463
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0119 0.0642 0.0646
Loa Loa (eye worm) hypothetical protein 0.005 0.0207 0.0208
Loa Loa (eye worm) hypothetical protein 0.1588 0.994 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.002 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0116
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.016 0.0899 0.0904
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0254 0.0504
Loa Loa (eye worm) AGC/PKA protein kinase 0.0128 0.0702 0.0706
Brugia malayi Methionine aminopeptidase protein type I 0.0044 0.0167 0.0168
Giardia lamblia Kinase, CMGC GSK 0.0058 0.0254 0.0504
Entamoeba histolytica protein kinase, putative 0.0034 0.0108 0.0204
Echinococcus granulosus dna polymerase eta 0.0043 0.0164 0.0165
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0115 0.0523
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0234 0.0235
Onchocerca volvulus 0.0036 0.0115 0.0211
Echinococcus granulosus geminin 0.0376 0.2268 0.2282
Mycobacterium leprae Probable lipase LipE 0.0036 0.0115 0.608
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0149 0.015
Echinococcus multilocularis glycogen phosphorylase 0.0791 0.4894 0.4923
Echinococcus granulosus dna polymerase kappa 0.0019 0.0008 0.0008
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0115 0.608
Entamoeba histolytica hypothetical protein 0.008 0.0395 0.0791
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Schistosoma mansoni hypothetical protein 0.0039 0.014 0.014
Entamoeba histolytica PH domain containing protein kinase, putative 0.013 0.0711 0.1439
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0494 0.0497
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0035 0.0132
Echinococcus multilocularis epidermal growth factor receptor 0.0247 0.1454 0.1463
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0238 0.024
Brugia malayi glutaminase DH11.1 0.0287 0.1708 0.1718
Onchocerca volvulus 0.0309 0.1846 0.3756
Schistosoma mansoni glycogen phosphorylase 0.0791 0.4894 0.4894
Treponema pallidum methionine aminopeptidase (map) 0.0044 0.0167 0.083
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0128 0.0702 0.3755
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0115 0.0219
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0116
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0035
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0128 0.0129
Brugia malayi jmjC domain containing protein 0.0057 0.0251 0.0252
Mycobacterium ulcerans hydrolase 0.0026 0.0057 0.0238
Echinococcus granulosus GA binding protein alpha chain 0.0081 0.0399 0.0402
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0054 0.0234 0.0235
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0008 0.0008
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0186 0.0187
Schistosoma mansoni tyrosine kinase 0.015 0.0837 0.0837
Brugia malayi Furin-like cysteine rich region family protein 0.0458 0.2786 0.2803
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0309 0.1846 0.1857
Brugia malayi beta-lactamase family protein 0.0036 0.0115 0.0116
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0116
Brugia malayi hypothetical protein 0.008 0.0395 0.0397
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0054 0.0234 0.0235
Schistosoma mansoni hypothetical protein 0.0039 0.014 0.014
Plasmodium falciparum transporter, putative 0.0309 0.1846 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0035 0.0055
Entamoeba histolytica SH2-protein kinase domain containing protein 0.002 0.0014 0.0012
Echinococcus multilocularis GA binding protein alpha chain 0.0081 0.0399 0.0402
Schistosoma mansoni hypothetical protein 0.0039 0.014 0.014
Brugia malayi intracellular kinase 0.0058 0.0254 0.0256
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0015 0.0014
Brugia malayi Variant SH3 domain containing protein 0.002 0.0016 0.0016
Onchocerca volvulus Matrilysin homolog 0.0048 0.0194 0.0373
Loa Loa (eye worm) hypothetical protein 0.0309 0.1846 0.1857
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0115 0.0116
Schistosoma mansoni nck2/grb4 0.002 0.0016 0.0016
Toxoplasma gondii methionine aminopeptidase 0.0044 0.0167 0.083
Schistosoma mansoni sodium/chloride dependent transporter 0.1588 0.994 0.994
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0044 0.0167 0.0776

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 1.7 uM Inhibition of KSP in A549 cells assessed by MPM-2 cytoblot assay ChEMBL. 17498954
EC50 (binding) = 1.7 uM Inhibition of KSP in A549 cells assessed by MPM-2 cytoblot assay ChEMBL. 17498954
EC50 (functional) = 6 uM Cytotoxicity against A549 cells after 60 hrs ChEMBL. 17498954
EC50 (functional) = 6 uM Cytotoxicity against A549 cells after 60 hrs ChEMBL. 17498954
IC50 (binding) = 3.1 uM Inhibition of human KSP expressed in Escherichia coli assessed by ATPase assay ChEMBL. 17498954
IC50 (binding) = 3.1 uM Inhibition of human KSP expressed in Escherichia coli assessed by ATPase assay ChEMBL. 17498954

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17498954

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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