Detailed information for compound 433008

Basic information

Technical information
  • TDR Targets ID: 433008
  • Name: 2-[[4-(4-fluorobutyl)phenyl]methylsulfanyl]-3 -methylchromen-4-one
  • MW: 356.454 | Formula: C21H21FO2S
  • H donors: 0 H acceptors: 1 LogP: 5.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: FCCCCc1ccc(cc1)CSc1oc2ccccc2c(=O)c1C
  • InChi: 1S/C21H21FO2S/c1-15-20(23)18-7-2-3-8-19(18)24-21(15)25-14-17-11-9-16(10-12-17)6-4-5-13-22/h2-3,7-12H,4-6,13-14H2,1H3
  • InChiKey: FSZGSKABPZYZBS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-(4-fluorobutyl)phenyl]methylsulfanyl]-3-methyl-chromen-4-one
  • 2-[[4-(4-fluorobutyl)phenyl]methylthio]-3-methyl-1-benzopyran-4-one
  • 2-[[4-(4-fluorobutyl)benzyl]thio]-3-methyl-chromone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0043 0.0093 0.1147
Plasmodium vivax SET domain protein, putative 0.0029 0.0049 0.2721
Echinococcus granulosus rhodopsin orphan GPCR 0.017 0.0485 0.0467
Echinococcus granulosus lamin dm0 0.0025 0.0036 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0077 0.0169
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0183 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0218 0.2521
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0093 0.1147
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0093 0.1147
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0049 0.0476
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0019 0.0051
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0183 0.2573
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0118 0.0324 0.4002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.116
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0043 0.0093 0.116
Schistosoma mansoni neuropeptide receptor 0.017 0.0485 0.7295
Entamoeba histolytica protein kinase rad3, putative 0.0127 0.0353 0.5227
Loa Loa (eye worm) TAR-binding protein 0.0118 0.0324 0.4002
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0021 0.0257
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0043 0.0093 0.1138
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0077 0.0882
Entamoeba histolytica hypothetical protein 0.0043 0.0093 0.116
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0077 0.0882
Onchocerca volvulus 0.017 0.0485 0.7048
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0024 0.0006
Brugia malayi Tachykinin-like peptides receptor 99D 0.017 0.0485 0.5988
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0126 0.1585
Schistosoma mansoni peptide (allatostatin)-like receptor 0.017 0.0485 0.7295
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0446
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0098 0.0263 0.0245
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0225 0.0658 0.1852
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0024 0.0063
Schistosoma mansoni hypothetical protein 0.017 0.0485 0.7295
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0043 0.0093 0.116
Loa Loa (eye worm) inositol-1 0.0037 0.0074 0.0914
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0547 0.6679
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0043 0.0093 0.6843
Loa Loa (eye worm) neuropeptide F receptor 0.017 0.0485 0.5988
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus thyrotropin releasing hormone receptor 0.017 0.0485 0.0467
Schistosoma mansoni lamin 0.0025 0.0036 0.0272
Schistosoma mansoni amine GPCR 0.017 0.0485 0.7295
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.017 0.0485 0.5988
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0077 0.0911
Brugia malayi hypothetical protein 0.0072 0.0181 0.2235
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0021 0.0257
Echinococcus multilocularis somatostatin receptor 0.017 0.0485 0.0467
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.017 0.0485 0.7295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0093 0.0937
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0043 0.0093 0.0215
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0024 0.0206
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0024 0.03
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Giardia lamblia GTOR 0.0225 0.0658 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.017 0.0485 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.017 0.0485 0.7295
Echinococcus granulosus rhodopsin orphan GPCR 0.017 0.0485 0.0467
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0048 0.0366
Leishmania major phosphatidylinositol kinase related protein, putative 0.0043 0.0093 0.0207
Onchocerca volvulus 0.0038 0.0077 0.0853
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0183 0.2262
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0043 0.0093 0.116
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.081 1
Echinococcus granulosus intermediate filament protein 0.0025 0.0036 0.0017
Onchocerca volvulus 0.017 0.0485 0.7048
Schistosoma mansoni opsin-like receptor 0.017 0.0485 0.7295
Onchocerca volvulus 0.017 0.0485 0.7048
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0126 0.3979
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus multilocularis alpha 1A adrenergic receptor 0.017 0.0485 0.0467
Brugia malayi neuropeptide F receptor 0.017 0.0485 0.5988
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0049 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0021 0.0257
Loa Loa (eye worm) RNA binding protein 0.0118 0.0324 0.4002
Brugia malayi TAR-binding protein 0.0118 0.0324 0.4002
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0366
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0074 0.0154
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0024 0.0131
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.03
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0225 0.0658 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0093 0.1147
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.116
Schistosoma mansoni lamin 0.0025 0.0036 0.0272
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Onchocerca volvulus 0.017 0.0485 0.7048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0024 0.0006
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0043 0.0093 0.0074
Schistosoma mansoni neuropeptide receptor 0.017 0.0485 0.7295
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0127 0.0353 0.0335
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0181 0.0163
Echinococcus granulosus peptide allatostatin:somatostatin 0.017 0.0485 0.0467
Onchocerca volvulus 0.0046 0.0101 0.1219
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.017 0.0485 0.5988
Echinococcus granulosus tm gpcr rhodopsin 0.017 0.0485 0.0467
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0225 0.0658 0.1852
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0183 0.2573
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0043 0.0093 0.0074
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0225 0.0658 0.1852
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0043 0.0093 0.0937
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0077 0.0736
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0043 0.0093 0.116
Loa Loa (eye worm) hypothetical protein 0.0046 0.0101 0.1253
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0225 0.0658 1
Schistosoma mansoni hypothetical protein 0.0046 0.0101 0.1294
Brugia malayi intermediate filament protein 0.0025 0.0036 0.0446
Echinococcus granulosus rhodopsin orphan GPCR 0.017 0.0485 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0093 0.1147
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0225 0.0658 1
Echinococcus multilocularis 0.0043 0.0093 0.0074
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0048 0.043
Echinococcus multilocularis lamin 0.0025 0.0036 0.0017
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0289 0.0784
Echinococcus multilocularis neuropeptide receptor A26 0.017 0.0485 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Onchocerca volvulus 0.0043 0.0093 0.1094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.0411 0.5073
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0093 0.1147
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus alpha 1A adrenergic receptor 0.017 0.0485 0.0467
Echinococcus granulosus tar DNA binding protein 0.0118 0.0324 0.0306
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0183 0.2395
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0951
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.002 0.0024
Schistosoma mansoni biogenic amine (dopamine) receptor 0.017 0.0485 0.7295
Giardia lamblia Hypothetical protein 0.0043 0.0093 0.116
Echinococcus multilocularis G-protein coupled receptor, putative 0.017 0.0485 0.0467
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.017 0.0485 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Plasmodium vivax hypothetical protein 0.0043 0.0093 0.6843
Mycobacterium ulcerans lipase LipD 0.0038 0.0077 0.2154
Loa Loa (eye worm) hypothetical protein 0.0146 0.0411 0.5073
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0517 0.6298
Onchocerca volvulus Glucosylceramidase homolog 0.018 0.0517 0.7534
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0074 0.0699
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0043 0.0093 0.1147
Schistosoma mansoni neuropeptide receptor 0.017 0.0485 0.7295
Onchocerca volvulus 0.017 0.0485 0.7048
Onchocerca volvulus 0.0029 0.0049 0.043
Echinococcus multilocularis dro:myosuppressin receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0021 0.0257
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0592 0.7308
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0043 0.0093 0.0215
Trichomonas vaginalis ap endonuclease, putative 0.002 0.002 0.0019
Echinococcus granulosus serotonin receptor 0.017 0.0485 0.0467
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus neuropeptide s receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0413 0.0395
Schistosoma mansoni amine GPCR 0.017 0.0485 0.7295
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0517 0.6298
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0024 0.0087
Echinococcus multilocularis neuropeptide FF receptor 2 0.017 0.0485 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0232
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0043 0.0093 0.0074
Loa Loa (eye worm) hypothetical protein 0.0098 0.0263 0.3251
Echinococcus multilocularis g protein coupled receptor 0.017 0.0485 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0021 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0077 0.0736
Brugia malayi RE15519p 0.017 0.0485 0.5988
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0183 0.6081
Mycobacterium tuberculosis Conserved protein 0.0038 0.0077 0.0882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0024 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0021 0.0257
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.116
Echinococcus multilocularis serotonin receptor 0.017 0.0485 0.0467
Entamoeba histolytica hypothetical protein 0.0043 0.0093 0.116
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0024 0.0063
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.03
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.0411 0.5073
Leishmania major hypothetical protein, conserved 0.1175 0.3605 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0021 0.0257
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0021 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0289 0.3906
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0183 0.2573
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0021 0.0257
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0024 0.0087
Echinococcus multilocularis Zinc finger, PHD finger 0.0043 0.0093 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0021 0.0002
Echinococcus granulosus neuropeptide Y receptor 0.017 0.0485 0.0467
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.017 0.0485 0.0467
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0101 0.0083
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0225 0.0658 1
Brugia malayi follicle stimulating hormone receptor 0.017 0.0485 0.5988
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0289 0.4232
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0049 0.0476
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.017 0.0485 0.5988
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0183 0.2262
Brugia malayi Melatonin receptor type 1A 0.017 0.0485 0.5988
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.0268 0.3305
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus fmrfamide receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus sex peptide receptor 0.017 0.0485 0.0467
Leishmania major phosphatidylinositol kinase, putative 0.0043 0.0093 0.0207
Schistosoma mansoni biogenic amine (dopamine) receptor 0.017 0.0485 0.7295
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0021 0.0002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0101 0.1253
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0225 0.0658 0.1782
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0093 0.1108
Brugia malayi RNA binding protein 0.0118 0.0324 0.4002
Onchocerca volvulus 0.0038 0.0077 0.0853
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Echinococcus granulosus rhodopsin orphan GPCR 0.017 0.0485 0.0467
Echinococcus multilocularis orexin receptor type 2 0.017 0.0485 0.0467
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3231 0.9988 0.9988
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0183 0.5999
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0225 0.0658 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.017 0.0485 0.7295
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0043 0.0093 0.116
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Echinococcus granulosus biogenic amine 5HT receptor 0.017 0.0485 0.0467
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0517 0.6298
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.0036 0.0446
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0043 0.0093 0.0937
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0021 0.0033
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.002 0.0073
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0024 0.0016
Echinococcus multilocularis neuropeptides capa receptor 0.017 0.0485 0.0467
Schistosoma mansoni neuropeptide f receptor 76f 0.017 0.0485 0.7295
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0024 0.0063
Schistosoma mansoni coup transcription factor 0.002 0.0021 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0118 0.0324 0.4778
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0024 0.0016
Echinococcus multilocularis fmrfamide receptor 0.017 0.0485 0.0467
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0181 0.2538
Schistosoma mansoni hypothetical protein 0.017 0.0485 0.7295
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0048 0.2582
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0289 0.3418
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0183 0.0459
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0021 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0077 0.0911
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.017 0.0485 0.0467
Echinococcus multilocularis neuropeptide Y receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.002 0.0251
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0043 0.0093 0.0215
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.116
Brugia malayi GnHR receptor homolog 0.017 0.0485 0.5988
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0019 0.0051
Echinococcus multilocularis tar DNA binding protein 0.0118 0.0324 0.0306
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0024 0.038
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0142 0.0398 0.5923
Echinococcus granulosus allatostatin A receptor 0.017 0.0485 0.0467
Brugia malayi beta-lactamase family protein 0.0038 0.0077 0.0951
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0225 0.0658 0.064
Echinococcus multilocularis neuropeptide receptor 0.017 0.0485 0.0467
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0517 0.6298
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0098 0.0263 0.0245
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0289 0.4232
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0043 0.0093 0.1138
Echinococcus granulosus FTZ F1 alpha 0.002 0.0021 0.0002
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0043 0.0093 0.0074
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0274 0.081 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0043 0.0093 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0021 0.0257
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0048 0.2582
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0024 0.0206
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0101 0.0083
Brugia malayi Muscleblind-like protein 0.0147 0.0413 0.51
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0049 0.0453
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.017 0.0485 0.7295
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus orexin receptor type 2 0.017 0.0485 0.0467
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0021 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Brugia malayi steroid hormone receptor 0.002 0.0021 0.0257
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.0411 0.5073
Schistosoma mansoni biogenic amine (5HT) receptor 0.017 0.0485 0.7295
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0183 0.6081
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0074 0.016
Schistosoma mansoni hypothetical protein 0.01 0.0268 0.3894
Echinococcus multilocularis neuropeptides capa receptor 0.017 0.0485 0.0467
Brugia malayi ecdysteroid receptor 0.002 0.0021 0.0257
Entamoeba histolytica hypothetical protein 0.0043 0.0093 0.116
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0043 0.0093 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Echinococcus granulosus 7TM GPCR rhodopsin 0.017 0.0485 0.0467
Schistosoma mansoni hypothetical protein 0.0046 0.0101 0.1294
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0024 0.038
Brugia malayi G protein-coupled receptor 0.017 0.0485 0.5988
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0048 0.0453
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0043 0.0093 0.0937
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.017 0.0485 0.7295
Brugia malayi Dopamine receptor protein 2 0.017 0.0485 0.5988
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.017 0.0485 0.0467
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.081 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0093 0.1147
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0077 0.0169
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0024 0.03
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Loa Loa (eye worm) hypothetical protein 0.0054 0.0126 0.156
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0366
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0043 0.0093 0.6843
Loa Loa (eye worm) G-protein coupled receptor 0.017 0.0485 0.5988
Echinococcus granulosus somatostatin receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) beta-lactamase 0.0038 0.0077 0.0951
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0101 0.1253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0021 0.0257
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.0937
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0074 0.0055
Brugia malayi RNA recognition motif domain containing protein 0.0118 0.0324 0.4002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0077 0.0951
Echinococcus granulosus neuropeptides capa receptor 0.017 0.0485 0.0467
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.002 0.0002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0077 0.2154
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0043 0.0093 0.0937
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0024 0.03
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0024 0.03
Onchocerca volvulus 0.017 0.0485 0.7048
Entamoeba histolytica hypothetical protein 0.0127 0.0353 0.5227
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0043 0.0093 0.0937
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0024 0.0131
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0043 0.0093 0.0937
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0049 0.0476
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0021 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0547 0.6679
Onchocerca volvulus 0.017 0.0485 0.7048
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.6843
Schistosoma mansoni alpha-1 adrenergic receptor 0.017 0.0485 0.7295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0021 0.0257
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.017 0.0485 0.0467
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.0658 0.8123
Onchocerca volvulus Huntingtin homolog 0.0124 0.0342 0.488
Onchocerca volvulus 0.0025 0.0036 0.0232
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0021 0.0257
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Echinococcus granulosus neuropeptide receptor A26 0.017 0.0485 0.0467
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0024 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0077 0.0882
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Mycobacterium tuberculosis Conserved protein 0.0038 0.0077 0.0882
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0117 0.1454
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus biogenic amine 5HT receptor 0.017 0.0485 0.0467
Onchocerca volvulus 0.017 0.0485 0.7048
Loa Loa (eye worm) hypothetical protein 0.0084 0.0218 0.2695
Echinococcus granulosus neuropeptide Y receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0024 0.0206
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0225 0.0658 0.064
Loa Loa (eye worm) neuropeptide F receptor 0.017 0.0485 0.5988
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0021 0.0002
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0289 0.4232
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0043 0.0093 0.0937
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0024 0.0016
Brugia malayi nuclear hormone receptor 0.002 0.0021 0.0257
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0077 0.0882
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0021 0.0002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.116
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0218 0.2521
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0366
Loa Loa (eye worm) hypothetical protein 0.0147 0.0413 0.51
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.6843
Mycobacterium leprae Probable lipase LipE 0.0038 0.0077 0.1989
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.017 0.0485 0.0467
Echinococcus granulosus muscleblind protein 0.0147 0.0413 0.0395
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Echinococcus granulosus tumor protein p63 0.0314 0.0934 0.0917
Toxoplasma gondii ABC1 family protein 0.0038 0.0077 0.0889
Schistosoma mansoni opsin-like receptor 0.017 0.0485 0.7295
Echinococcus multilocularis musashi 0.0025 0.0036 0.0017
Schistosoma mansoni biogenic amine receptor 0.017 0.0485 0.7295
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0951
Trichomonas vaginalis esterase, putative 0.0038 0.0077 0.0736
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0289 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0043 0.0093 0.0215
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0607
Brugia malayi 6-phosphofructokinase 0.0107 0.0289 0.3571
Onchocerca volvulus 0.0021 0.0024 0.0053
Onchocerca volvulus 0.0038 0.0077 0.0853
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0289 0.4232
Echinococcus granulosus GPCR family 2 0.0046 0.0101 0.0083
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Loa Loa (eye worm) hypothetical protein 0.0072 0.0183 0.2262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0093 0.0937
Schistosoma mansoni neuropeptide F-like receptor 0.017 0.0485 0.7295
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0289 1
Onchocerca volvulus 0.0025 0.0036 0.0232
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Schistosoma mansoni tar DNA-binding protein 0.0118 0.0324 0.4778
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0021 0.0002
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0289 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0074 0.0865
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0043 0.0093 0.0937
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0043 0.0093 0.0215
Brugia malayi AKH receptor 0.017 0.0485 0.5988
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0225 0.0658 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.002 0.0004
Brugia malayi G protein-coupled receptor F59B2.13 0.017 0.0485 0.5988
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0024 0.03
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0021 0.0002
Brugia malayi beta-lactamase family protein 0.0038 0.0077 0.0951
Echinococcus granulosus rhodopsin orphan GPCR 0.017 0.0485 0.0467
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.017 0.0485 0.0467
Echinococcus multilocularis G protein coupled receptor 139 0.017 0.0485 0.0467
Giardia lamblia Phosphatidylinositol 4-kinase 0.0043 0.0093 0.116
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0043 0.0093 0.116
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.0054 0.0126 0.156
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0183 0.2262
Leishmania major phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0021 0.0257
Brugia malayi Serotonin/octopamine receptor family protein 7 0.017 0.0485 0.5988
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0021 0.0002
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.002 0.0024
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0127 0.0353 0.4357
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0951
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0289 0.3571
Schistosoma mansoni ap endonuclease 0.002 0.002 0.0024
Toxoplasma gondii target of rapamycin (TOR), putative 0.0225 0.0658 1
Leishmania major hypothetical protein, conserved 0.0038 0.0077 0.0162
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0126 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0043 0.0093 0.116
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0024 0.03
Echinococcus granulosus neuropeptides capa receptor 0.017 0.0485 0.0467
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.0036 0.0446
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0046 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0093 0.0937
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0093 0.2588
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0517 0.6298
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus neuropeptide FF receptor 2 0.017 0.0485 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0048 0.1018
Echinococcus multilocularis g protein coupled receptor 0.017 0.0485 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0021 0.0257
Loa Loa (eye worm) hypothetical protein 0.01 0.0268 0.3305
Onchocerca volvulus Huntingtin homolog 0.0124 0.0342 0.488
Onchocerca volvulus 0.0072 0.0183 0.2466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Loa Loa (eye worm) oxidoreductase 0.0021 0.0024 0.03
Onchocerca volvulus 0.0021 0.0024 0.0053
Schistosoma mansoni myosin xvIII 0.017 0.0485 0.7295
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0043 0.0093 0.0074
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0021 0.0033
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0043 0.0093 0.0074
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0127 0.0353 0.0968
Echinococcus multilocularis GPCR, family 2 0.0046 0.0101 0.0083
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0043 0.0093 0.0937
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0021 0.0257
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0183 0.6081
Echinococcus granulosus dro:myosuppressin receptor 0.017 0.0485 0.0467
Brugia malayi hypothetical protein 0.0124 0.0342 0.4225
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0077 0.0951
Echinococcus granulosus tm gpcr rhodopsin 0.017 0.0485 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.0398 0.4792
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0021 0.0257
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0021 0.0033
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0077 0.0058
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0183 0.5999
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.017 0.0485 0.7295
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0077 0.0736
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0074 0.0843
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0024 0.0016
Echinococcus granulosus tachykinin peptides receptor 99D 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.0142 0.0398 0.4913
Brugia malayi G-protein coupled receptor 0.017 0.0485 0.5988
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0429
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0043 0.0093 0.6843
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0093 0.1147
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0019 0.0232
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0127 0.0353 0.0335
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.002 0.0024
Entamoeba histolytica hypothetical protein 0.0072 0.0181 0.2538
Schistosoma mansoni amine GPCR 0.017 0.0485 0.7295
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.017 0.0485 0.5988
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0049 0.0476
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0951
Schistosoma mansoni biogenic amine (dopamine) receptor 0.017 0.0485 0.7295
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0048 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Schistosoma mansoni inositol monophosphatase 0.0037 0.0074 0.0865
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.081 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0225 0.0658 0.1852
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0024 0.007
Leishmania major hypothetical protein, unknown function 0.0043 0.0093 0.0207
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0117 0.1454
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0043 0.0093 0.0937
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus rhodopsin orphan GPCR 0.017 0.0485 0.0467
Brugia malayi sulfakinin receptor protein 0.017 0.0485 0.5988
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0043 0.0093 0.1138
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0077 0.0736
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0024 0.0087
Schistosoma mansoni adenoreceptor 0.017 0.0485 0.7295
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0024 0.0131
Schistosoma mansoni thyroid hormone receptor 0.002 0.0021 0.0033
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.017 0.0485 0.7048
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.116
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0093 0.1147
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.017 0.0485 0.0467
Schistosoma mansoni thyroid hormone receptor 0.002 0.0021 0.0033
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0289 0.4232
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0127 0.0353 0.5227
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0024 0.0131
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0077 0.0736
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0077 0.2154
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3235 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Loa Loa (eye worm) phosphatidylinositol kinase 0.0043 0.0093 0.1147
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0074 1
Brugia malayi ORL1-like opioid receptor 0.017 0.0485 0.5988
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0263 0.3091
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0074 0.0865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0077 0.0058
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0093 0.1147
Onchocerca volvulus 0.0232 0.0679 1
Toxoplasma gondii FATC domain-containing protein 0.0127 0.0353 0.5216
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0289 0.4232
Schistosoma mansoni hypothetical protein 0.0046 0.0101 0.1294
Entamoeba histolytica hypothetical protein 0.0043 0.0093 0.116
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0021 0.0002
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.017 0.0485 0.0467
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0021 0.0257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0021 0.0257
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0093 0.116
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0021 0.0257
Brugia malayi FAT domain containing protein 0.0098 0.0263 0.3251
Onchocerca volvulus 0.017 0.0485 0.7048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0021 0.0002
Echinococcus multilocularis fmrfamide receptor 0.017 0.0485 0.0467
Schistosoma mansoni biogenic amine receptor 0.017 0.0485 0.7295
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0021 0.0257
Schistosoma mansoni neuropeptide receptor 0.017 0.0485 0.7295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0043 0.0093 0.0074
Onchocerca volvulus 0.0043 0.0093 0.1094
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0043 0.0093 0.0215
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.017 0.0485 0.0467
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.0215
Echinococcus multilocularis tumor protein p63 0.0314 0.0934 0.0917
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0019 0.0232
Schistosoma mansoni hypothetical protein 0.0098 0.0263 0.3826
Echinococcus multilocularis tachykinin peptides receptor 99D 0.017 0.0485 0.0467
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.0658 0.8123
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0043 0.0093 0.0215
Echinococcus granulosus G protein coupled receptor 139 0.017 0.0485 0.0467
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0021 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Loa Loa (eye worm) hypothetical protein 0.0072 0.0183 0.2262
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0024 0.007
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0126 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0951
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.002 0.0057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0951
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0043 0.0093 0.0937
Schistosoma mansoni nuclear hormone receptor 0.002 0.0021 0.0033
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0289 0.3571
Leishmania major phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.0207
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0225 0.0658 0.1782
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0024 0.0206
Onchocerca volvulus 0.017 0.0485 0.7048
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0183 0.6081
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0019 0.0232
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0366
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.081 1
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0289 0.3418
Onchocerca volvulus 0.017 0.0485 0.7048
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.116
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0289 0.3571
Schistosoma mansoni ap endonuclease 0.002 0.002 0.0024
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0126 1
Schistosoma mansoni hypothetical protein 0.017 0.0485 0.7295
Brugia malayi beta-lactamase 0.0038 0.0077 0.0951
Schistosoma mansoni hypothetical protein 0.017 0.0485 0.7295
Schistosoma mansoni tar DNA-binding protein 0.0118 0.0324 0.4778
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0043 0.0093 0.116
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0183 0.2395
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0043 0.0093 0.116
Loa Loa (eye worm) hypothetical protein 0.0043 0.0093 0.1147
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.017 0.0485 0.0467
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Schistosoma mansoni amine GPCR 0.017 0.0485 0.7295
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.0054 0.0126 0.156
Schistosoma mansoni biogenic amine receptor 0.017 0.0485 0.7295
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0021 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.081 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.116
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0225 0.0658 0.1782
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0127 0.0353 0.5227
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0049 0.003
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0289 0.3418
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0117 0.1454
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0043 0.0093 0.116
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.0658 0.8123
Onchocerca volvulus 0.017 0.0485 0.7048
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0024 0.03
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0048 0.043
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0021 0.0002
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0084 0.0218 0.0578
Schistosoma mansoni growth hormone secretagogue receptor 0.017 0.0485 0.7295
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0074 0.0699
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0024 0.0131
Entamoeba histolytica hypothetical protein 0.0072 0.0181 0.2538
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0024 0.0131
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Schistosoma mansoni tar DNA-binding protein 0.0118 0.0324 0.4778
Schistosoma mansoni hypothetical protein 0.0046 0.0101 0.1294
Schistosoma mansoni intermediate filament proteins 0.0025 0.0036 0.0272
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0077 0.1989
Echinococcus granulosus g protein coupled receptor 0.017 0.0485 0.0467
Echinococcus multilocularis sex peptide receptor 0.017 0.0485 0.0467
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0024 0.03
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0274 0.081 1
Entamoeba histolytica hypothetical protein 0.0072 0.0181 0.2538
Echinococcus granulosus serine protein kinase ATM 0.0127 0.0353 0.0335
Brugia malayi putative neuropeptide receptor NPR1 0.017 0.0485 0.5988
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0093 0.6843
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0289 0.0271
Schistosoma mansoni tar DNA-binding protein 0.0118 0.0324 0.4778
Brugia malayi larval opioid receptor 0.017 0.0485 0.5988
Mycobacterium ulcerans hypothetical protein 0.0038 0.0077 0.2154
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0142 0.0398 0.5932
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.017 0.0485 0.7295
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0077 0.5347
Echinococcus multilocularis biogenic amine (5HT) receptor 0.017 0.0485 0.0467
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0024 0.0131
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0117 0.1454
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0077 0.0911
Echinococcus multilocularis neuropeptide Y receptor 0.017 0.0485 0.0467
Brugia malayi Serotonin receptor 0.017 0.0485 0.5988
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.0215
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0183 0.6081
Loa Loa (eye worm) intermediate filament protein 0.0025 0.0036 0.0446
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0024 0.0131
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0077 0.0882
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0289 0.3418
Trypanosoma cruzi target of rapamycin kinase 3 0.0225 0.0658 0.1852
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0093 0.1147
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0021 0.0033
Mycobacterium ulcerans beta-lactamase 0.0038 0.0077 0.2154
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.002 0.0002
Schistosoma mansoni neuropeptide F-like receptor 0.017 0.0485 0.7295
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0062 0.1419
Onchocerca volvulus 0.017 0.0485 0.7048
Onchocerca volvulus 0.017 0.0485 0.7048
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0043 0.0093 0.0074
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0024 0.0131
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0048 0.2582
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Echinococcus multilocularis muscleblind protein 0.0147 0.0413 0.0395
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0127 0.0353 0.5227
Echinococcus multilocularis serine protein kinase ATM 0.0127 0.0353 0.0335
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0043 0.0093 0.1147
Mycobacterium ulcerans hypothetical protein 0.0072 0.0183 0.6081
Brugia malayi Dopamine receptor protein 1 0.017 0.0485 0.5988
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0183 0.6081
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0181 0.0163
Onchocerca volvulus 0.017 0.0485 0.7048
Loa Loa (eye worm) hypothetical protein 0.0046 0.0101 0.1248
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.081 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.002 0.0251
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0024 0.0206
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0183 0.0459
Loa Loa (eye worm) hypothetical protein 0.0072 0.0183 0.2262
Schistosoma mansoni hypothetical protein 0.0043 0.0093 0.116
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0225 0.0658 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0077 0.0882
Loa Loa (eye worm) hypothetical protein 0.0147 0.0413 0.51
Echinococcus granulosus g protein coupled receptor 0.017 0.0485 0.0467
Onchocerca volvulus 0.0021 0.0024 0.0053
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0024 0.0206
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0021 0.0033
Echinococcus multilocularis neuropeptide receptor 0.017 0.0485 0.0467
Brugia malayi neuropeptide F receptor 0.017 0.0485 0.5988
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0021 0.0257
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.0101 0.1288
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0289 0.0754
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0225 0.0658 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0074 0.0699
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0043 0.0093 0.0074
Trichomonas vaginalis ap endonuclease, putative 0.002 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0021 0.0257
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0048 0.2582
Schistosoma mansoni opsin-like receptor 0.017 0.0485 0.7295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0074 0.2044
Schistosoma mansoni hypothetical protein 0.0072 0.0181 0.2538
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0024 0.0206
Brugia malayi Pre-SET motif family protein 0.0204 0.0592 0.7308
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0043 0.0093 0.116
Schistosoma mansoni fkbp-rapamycin associated protein 0.0127 0.0353 0.5227
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0043 0.0093 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.1131 0.347 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0021 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0517 0.6298
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0021 0.0257
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0021 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0021 0.0033
Schistosoma mansoni biogenic amine (5HT) receptor 0.017 0.0485 0.7295
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.002 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0021 0.0257
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0049 0.003
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.002 0.0004
Echinococcus granulosus neuropeptide receptor 0.017 0.0485 0.0467
Echinococcus multilocularis serotonin receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.017 0.0485 0.0467
Onchocerca volvulus Neuropeptide F receptor homolog 0.017 0.0485 0.7048
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0074 0.0055
Loa Loa (eye worm) hypothetical protein 0.0054 0.0126 0.156
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0101 0.1253
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0225 0.0658 1
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0077 0.0882
Loa Loa (eye worm) hypothetical protein 0.0124 0.0342 0.4225
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0093 0.1147
Onchocerca volvulus 0.0021 0.0024 0.0053
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0043 0.0093 0.1138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Brugia malayi phosphofructokinase 0.0107 0.0289 0.3571
Brugia malayi putative neuropeptide receptor 0.017 0.0485 0.5988
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.017 0.0485 0.5988
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.0658 0.8123
Echinococcus granulosus g-protein coupled receptor 0.017 0.0485 0.0467
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0043 0.0093 0.1138
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.6843
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0043 0.0093 0.116
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0024 0.0016
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.017 0.0485 0.5988
Loa Loa (eye worm) melatonin receptor type 1A 0.017 0.0485 0.5988
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.017 0.0485 0.7295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0127 0.0353 0.4357
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0024 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Loa Loa (eye worm) G-protein coupled receptor 0.017 0.0485 0.5988
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0183 0.6081
Echinococcus granulosus 7tm_1 domain containing protein 0.017 0.0485 0.0467
Onchocerca volvulus 0.017 0.0485 0.7048
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0366
Brugia malayi 6-phosphofructokinase 0.0107 0.0289 0.3571
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0517 0.6298
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0062 0.0666
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0021 0.0257
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.0717 1
Brugia malayi G-protein coupled receptor 0.017 0.0485 0.5988
Echinococcus granulosus neuropeptide receptor 0.017 0.0485 0.0467
Brugia malayi Dopamine receptor 0.017 0.0485 0.5988
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0021 0.0002
Brugia malayi gonadotropin-releasing hormone receptor 2 0.017 0.0485 0.5988
Echinococcus granulosus lamin 0.0025 0.0036 0.0017
Brugia malayi Inositol-1 0.0037 0.0074 0.0914
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0225 0.0658 0.064
Echinococcus granulosus hypothetical protein 0.017 0.0485 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0024 0.0206
Schistosoma mansoni amine GPCR 0.017 0.0485 0.7295
Schistosoma mansoni histamine h1 receptor 0.017 0.0485 0.7295
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0225 0.0658 0.064
Loa Loa (eye worm) hypothetical protein 0.0127 0.0353 0.4357
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0021 0.0257
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0043 0.0093 0.116
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0289 0.0271
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.017 0.0485 0.5988
Loa Loa (eye worm) hypothetical protein 0.0054 0.0126 0.156
Echinococcus granulosus rhodopsin orphan GPCR 0.017 0.0485 0.0467
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0043 0.0093 0.0207
Brugia malayi Pre-SET motif family protein 0.0029 0.0049 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0142 0.0398 0.4792
Echinococcus multilocularis allatostatin A receptor 0.017 0.0485 0.0467
Trichomonas vaginalis set domain proteins, putative 0.0232 0.0679 0.8351
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0101 0.0083
Echinococcus granulosus tm gpcr rhodopsin 0.017 0.0485 0.0467
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0024 0.0131
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0043 0.0093 0.6843
Loa Loa (eye worm) follicle stimulating hormone receptor 0.017 0.0485 0.5988
Mycobacterium tuberculosis Conserved protein 0.0038 0.0077 0.0882
Echinococcus granulosus g protein coupled receptor 0.017 0.0485 0.0467
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0048 0.0453
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Loa Loa (eye worm) hypothetical protein 0.0124 0.0342 0.4225
Brugia malayi Serotonin receptor 0.017 0.0485 0.5988
Schistosoma mansoni inositol monophosphatase 0.0037 0.0074 0.0865
Echinococcus multilocularis g-protein coupled receptor 0.017 0.0485 0.0467
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0225 0.0658 0.1782
Echinococcus multilocularis lamin dm0 0.0025 0.0036 0.0017
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) TYRA-2 protein 0.017 0.0485 0.5988
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0127 0.0353 0.0968
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Echinococcus multilocularis g protein coupled receptor 0.017 0.0485 0.0467
Entamoeba histolytica hypothetical protein 0.0072 0.0181 0.2538
Echinococcus multilocularis neuropeptide s receptor 0.017 0.0485 0.0467
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0043 0.0093 0.0937
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.017 0.0485 0.7295
Leishmania major phosphatidylinositol 3-kinase, putative 0.0225 0.0658 0.1782
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0101 0.0083
Onchocerca volvulus 0.017 0.0485 0.7048
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9 nM Inhibition of bovine mitochondrial MC1 ChEMBL. 17696417

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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