Detailed information for compound 433022

Basic information

Technical information
  • TDR Targets ID: 433022
  • Name: 2-[[4-(4-fluoranylbutyl)phenyl]methylsulfanyl ]-3-methylchromen-4-one
  • MW: 355.456 | Formula: C21H21FO2S
  • H donors: 0 H acceptors: 1 LogP: 5.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: [18F]CCCCc1ccc(cc1)CSc1oc2ccccc2c(=O)c1C
  • InChi: 1S/C21H21FO2S/c1-15-20(23)18-7-2-3-8-19(18)24-21(15)25-14-17-11-9-16(10-12-17)6-4-5-13-22/h2-3,7-12H,4-6,13-14H2,1H3/i22-1
  • InChiKey: FSZGSKABPZYZBS-KVTPGWOSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-(4-fluoranylbutyl)phenyl]methylsulfanyl]-3-methyl-chromen-4-one
  • 2-[[4-(4-fluoranylbutyl)phenyl]methylthio]-3-methyl-1-benzopyran-4-one
  • 2-[[4-(4-fluoranylbutyl)benzyl]thio]-3-methyl-chromone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0043 0.0093 0.6843
Loa Loa (eye worm) neuropeptide F receptor 0.017 0.0485 0.5988
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0547 0.6679
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0077 0.0911
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.017 0.0485 0.5988
Schistosoma mansoni amine GPCR 0.017 0.0485 0.7295
Schistosoma mansoni lamin 0.0025 0.0036 0.0272
Echinococcus granulosus thyrotropin releasing hormone receptor 0.017 0.0485 0.0467
Brugia malayi Tachykinin-like peptides receptor 99D 0.017 0.0485 0.5988
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0024 0.0006
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0043 0.0093 0.116
Loa Loa (eye worm) inositol-1 0.0037 0.0074 0.0914
Schistosoma mansoni hypothetical protein 0.017 0.0485 0.7295
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0024 0.0063
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0225 0.0658 0.1852
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0446
Schistosoma mansoni peptide (allatostatin)-like receptor 0.017 0.0485 0.7295
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0098 0.0263 0.0245
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0126 0.1585
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Loa Loa (eye worm) TAR-binding protein 0.0118 0.0324 0.4002
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0021 0.0257
Schistosoma mansoni neuropeptide receptor 0.017 0.0485 0.7295
Entamoeba histolytica protein kinase rad3, putative 0.0127 0.0353 0.5227
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0043 0.0093 0.116
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.116
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0118 0.0324 0.4002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0049 0.0476
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0019 0.0051
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0183 0.2573
Onchocerca volvulus 0.017 0.0485 0.7048
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0077 0.0882
Entamoeba histolytica hypothetical protein 0.0043 0.0093 0.116
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0077 0.0882
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0043 0.0093 0.1138
Echinococcus granulosus rhodopsin orphan GPCR 0.017 0.0485 0.0467
Echinococcus granulosus lamin dm0 0.0025 0.0036 0.0017
Loa Loa (eye worm) hypothetical protein 0.0043 0.0093 0.1147
Plasmodium vivax SET domain protein, putative 0.0029 0.0049 0.2721
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0093 0.1147
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0093 0.1147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0218 0.2521
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0183 0.0459
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0077 0.0169
Schistosoma mansoni neuropeptide receptor 0.017 0.0485 0.7295
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0043 0.0093 0.0074
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0024 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Onchocerca volvulus 0.017 0.0485 0.7048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Schistosoma mansoni lamin 0.0025 0.0036 0.0272
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0043 0.0093 0.0074
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0183 0.2573
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0225 0.0658 0.1852
Echinococcus granulosus tm gpcr rhodopsin 0.017 0.0485 0.0467
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.017 0.0485 0.5988
Onchocerca volvulus 0.0046 0.0101 0.1219
Echinococcus granulosus peptide allatostatin:somatostatin 0.017 0.0485 0.0467
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0181 0.0163
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0127 0.0353 0.0335
Echinococcus multilocularis alpha 1A adrenergic receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0126 0.3979
Onchocerca volvulus 0.017 0.0485 0.7048
Schistosoma mansoni opsin-like receptor 0.017 0.0485 0.7295
Onchocerca volvulus 0.017 0.0485 0.7048
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.116
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0093 0.1147
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.03
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0225 0.0658 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0366
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0074 0.0154
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0024 0.0131
Brugia malayi TAR-binding protein 0.0118 0.0324 0.4002
Loa Loa (eye worm) RNA binding protein 0.0118 0.0324 0.4002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0021 0.0257
Brugia malayi neuropeptide F receptor 0.017 0.0485 0.5988
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0049 0.003
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0048 0.0366
Echinococcus granulosus rhodopsin orphan GPCR 0.017 0.0485 0.0467
Leishmania major phosphatidylinositol kinase related protein, putative 0.0043 0.0093 0.0207
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.017 0.0485 0.7295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Giardia lamblia GTOR 0.0225 0.0658 1
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.017 0.0485 0.0467
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0024 0.0206
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0024 0.03
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0043 0.0093 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0093 0.0937
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.017 0.0485 0.7295
Echinococcus granulosus intermediate filament protein 0.0025 0.0036 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.081 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0043 0.0093 0.116
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0183 0.2262
Onchocerca volvulus 0.0038 0.0077 0.0853
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Brugia malayi hypothetical protein 0.0072 0.0181 0.2235
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Echinococcus multilocularis somatostatin receptor 0.017 0.0485 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0021 0.0257
Onchocerca volvulus Glucosylceramidase homolog 0.018 0.0517 0.7534
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0517 0.6298
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0021 0.0257
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus multilocularis dro:myosuppressin receptor 0.017 0.0485 0.0467
Onchocerca volvulus 0.0029 0.0049 0.043
Onchocerca volvulus 0.017 0.0485 0.7048
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0043 0.0093 0.1147
Schistosoma mansoni neuropeptide receptor 0.017 0.0485 0.7295
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0074 0.0699
Echinococcus multilocularis G-protein coupled receptor, putative 0.017 0.0485 0.0467
Giardia lamblia Hypothetical protein 0.0043 0.0093 0.116
Schistosoma mansoni biogenic amine (dopamine) receptor 0.017 0.0485 0.7295
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Loa Loa (eye worm) hypothetical protein 0.0146 0.0411 0.5073
Mycobacterium ulcerans lipase LipD 0.0038 0.0077 0.2154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Plasmodium vivax hypothetical protein 0.0043 0.0093 0.6843
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.017 0.0485 0.0467
Echinococcus multilocularis neuropeptide receptor A26 0.017 0.0485 0.0467
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0289 0.0784
Echinococcus multilocularis lamin 0.0025 0.0036 0.0017
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0048 0.043
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.002 0.0024
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0074 0.016
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0951
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0183 0.2395
Echinococcus granulosus tar DNA binding protein 0.0118 0.0324 0.0306
Echinococcus granulosus alpha 1A adrenergic receptor 0.017 0.0485 0.0467
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0093 0.1147
Onchocerca volvulus 0.0043 0.0093 0.1094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.0411 0.5073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Brugia malayi intermediate filament protein 0.0025 0.0036 0.0446
Schistosoma mansoni hypothetical protein 0.0046 0.0101 0.1294
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0225 0.0658 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0101 0.1253
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0043 0.0093 0.116
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0043 0.0093 0.0937
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0225 0.0658 0.1852
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0077 0.0736
Echinococcus multilocularis 0.0043 0.0093 0.0074
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0225 0.0658 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0093 0.1147
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Echinococcus granulosus rhodopsin orphan GPCR 0.017 0.0485 0.0467
Echinococcus multilocularis Zinc finger, PHD finger 0.0043 0.0093 0.0074
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0024 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0021 0.0257
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0183 0.2573
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0225 0.0658 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0101 0.0083
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.017 0.0485 0.0467
Echinococcus granulosus neuropeptide Y receptor 0.017 0.0485 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0021 0.0002
Echinococcus multilocularis serotonin receptor 0.017 0.0485 0.0467
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0021 0.0257
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0024 0.0087
Mycobacterium tuberculosis Conserved protein 0.0038 0.0077 0.0882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0183 0.6081
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0289 0.3906
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0021 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Leishmania major hypothetical protein, conserved 0.1175 0.3605 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0021 0.0257
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.03
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.0411 0.5073
Entamoeba histolytica hypothetical protein 0.0043 0.0093 0.116
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0024 0.0063
Echinococcus multilocularis g protein coupled receptor 0.017 0.0485 0.0467
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0043 0.0093 0.0074
Loa Loa (eye worm) hypothetical protein 0.0098 0.0263 0.3251
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0232
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0077 0.0736
Brugia malayi RE15519p 0.017 0.0485 0.5988
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0021 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0413 0.0395
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus neuropeptide s receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0024 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.002 0.002 0.0019
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0043 0.0093 0.0215
Echinococcus granulosus serotonin receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0592 0.7308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Echinococcus multilocularis neuropeptide FF receptor 2 0.017 0.0485 0.0467
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0024 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0517 0.6298
Schistosoma mansoni amine GPCR 0.017 0.0485 0.7295
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0289 0.3418
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0048 0.2582
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Schistosoma mansoni hypothetical protein 0.017 0.0485 0.7295
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0181 0.2538
Echinococcus multilocularis fmrfamide receptor 0.017 0.0485 0.0467
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0024 0.0016
Schistosoma mansoni coup transcription factor 0.002 0.0021 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0118 0.0324 0.4778
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0024 0.0063
Brugia malayi GnHR receptor homolog 0.017 0.0485 0.5988
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.116
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0043 0.0093 0.0215
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.002 0.0251
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0077 0.0911
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.017 0.0485 0.0467
Echinococcus multilocularis neuropeptide Y receptor 0.017 0.0485 0.0467
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0183 0.0459
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0021 0.0002
Echinococcus granulosus biogenic amine 5HT receptor 0.017 0.0485 0.0467
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0517 0.6298
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.0036 0.0446
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0043 0.0093 0.116
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.017 0.0485 0.7295
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0225 0.0658 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0183 0.5999
Schistosoma mansoni neuropeptide f receptor 76f 0.017 0.0485 0.7295
Echinococcus multilocularis neuropeptides capa receptor 0.017 0.0485 0.0467
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0024 0.0016
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.002 0.0073
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0021 0.0033
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0043 0.0093 0.0937
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0225 0.0658 0.1782
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0101 0.1253
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0021 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.017 0.0485 0.7295
Leishmania major phosphatidylinositol kinase, putative 0.0043 0.0093 0.0207
Echinococcus granulosus sex peptide receptor 0.017 0.0485 0.0467
Echinococcus multilocularis orexin receptor type 2 0.017 0.0485 0.0467
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3231 0.9988 0.9988
Echinococcus granulosus rhodopsin orphan GPCR 0.017 0.0485 0.0467
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Onchocerca volvulus 0.0038 0.0077 0.0853
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0093 0.1108
Brugia malayi RNA binding protein 0.0118 0.0324 0.4002
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.017 0.0485 0.5988
Brugia malayi follicle stimulating hormone receptor 0.017 0.0485 0.5988
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0049 0.0476
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0289 0.4232
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus fmrfamide receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.0268 0.3305
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Brugia malayi Melatonin receptor type 1A 0.017 0.0485 0.5988
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0183 0.2262
Echinococcus granulosus 7TM GPCR rhodopsin 0.017 0.0485 0.0467
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0024 0.038
Schistosoma mansoni hypothetical protein 0.0046 0.0101 0.1294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0093 0.1147
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.017 0.0485 0.0467
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.081 1
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Brugia malayi Dopamine receptor protein 2 0.017 0.0485 0.5988
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.017 0.0485 0.7295
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0043 0.0093 0.0937
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0048 0.0453
Brugia malayi G protein-coupled receptor 0.017 0.0485 0.5988
Schistosoma mansoni hypothetical protein 0.01 0.0268 0.3894
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0074 0.016
Schistosoma mansoni biogenic amine (5HT) receptor 0.017 0.0485 0.7295
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0183 0.6081
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.0411 0.5073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0043 0.0093 0.0074
Entamoeba histolytica hypothetical protein 0.0043 0.0093 0.116
Brugia malayi ecdysteroid receptor 0.002 0.0021 0.0257
Echinococcus multilocularis neuropeptides capa receptor 0.017 0.0485 0.0467
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0101 0.0083
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0024 0.0206
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0048 0.2582
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0043 0.0093 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0021 0.0257
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0274 0.081 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0043 0.0093 0.0074
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Brugia malayi steroid hormone receptor 0.002 0.0021 0.0257
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0021 0.0033
Echinococcus granulosus orexin receptor type 2 0.017 0.0485 0.0467
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.017 0.0485 0.7295
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0049 0.0453
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Brugia malayi Muscleblind-like protein 0.0147 0.0413 0.51
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus allatostatin A receptor 0.017 0.0485 0.0467
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0142 0.0398 0.5923
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0024 0.038
Echinococcus multilocularis tar DNA binding protein 0.0118 0.0324 0.0306
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0019 0.0051
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0289 0.4232
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0043 0.0093 0.1138
Echinococcus granulosus FTZ F1 alpha 0.002 0.0021 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0517 0.6298
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0098 0.0263 0.0245
Echinococcus multilocularis neuropeptide receptor 0.017 0.0485 0.0467
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0225 0.0658 0.064
Brugia malayi beta-lactamase family protein 0.0038 0.0077 0.0951
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus granulosus neuropeptide Y receptor 0.017 0.0485 0.0467
Onchocerca volvulus 0.017 0.0485 0.7048
Loa Loa (eye worm) hypothetical protein 0.0084 0.0218 0.2695
Echinococcus granulosus biogenic amine 5HT receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0117 0.1454
Mycobacterium tuberculosis Conserved protein 0.0038 0.0077 0.0882
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0225 0.0658 0.064
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0024 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0366
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.0658 0.8123
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.017 0.0485 0.0467
Schistosoma mansoni alpha-1 adrenergic receptor 0.017 0.0485 0.7295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0021 0.0257
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.6843
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0024 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0077 0.0882
Echinococcus granulosus neuropeptide receptor A26 0.017 0.0485 0.0467
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0021 0.0257
Onchocerca volvulus Huntingtin homolog 0.0124 0.0342 0.488
Onchocerca volvulus 0.0025 0.0036 0.0232
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0043 0.0093 0.0937
Onchocerca volvulus 0.017 0.0485 0.7048
Entamoeba histolytica hypothetical protein 0.0127 0.0353 0.5227
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0024 0.03
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0024 0.03
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0043 0.0093 0.0937
Onchocerca volvulus 0.017 0.0485 0.7048
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0547 0.6679
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0021 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0049 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0043 0.0093 0.0937
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0024 0.0131
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0101 0.1253
Echinococcus granulosus somatostatin receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) beta-lactamase 0.0038 0.0077 0.0951
Loa Loa (eye worm) G-protein coupled receptor 0.017 0.0485 0.5988
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0366
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0043 0.0093 0.6843
Loa Loa (eye worm) hypothetical protein 0.0054 0.0126 0.156
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0024 0.03
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0077 0.0169
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0077 0.2154
Echinococcus granulosus neuropeptides capa receptor 0.017 0.0485 0.0467
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.002 0.0002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0077 0.0951
Brugia malayi RNA recognition motif domain containing protein 0.0118 0.0324 0.4002
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0074 0.0055
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.0937
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0021 0.0257
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0021 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0024 0.03
Brugia malayi G protein-coupled receptor F59B2.13 0.017 0.0485 0.5988
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.002 0.0004
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0225 0.0658 1
Brugia malayi AKH receptor 0.017 0.0485 0.5988
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0043 0.0093 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0043 0.0093 0.0937
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0074 0.0865
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0289 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.017 0.0485 0.0467
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Brugia malayi beta-lactamase family protein 0.0038 0.0077 0.0951
Echinococcus granulosus rhodopsin orphan GPCR 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.0072 0.0183 0.2262
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Echinococcus granulosus GPCR family 2 0.0046 0.0101 0.0083
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0289 0.4232
Onchocerca volvulus 0.0038 0.0077 0.0853
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0021 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0118 0.0324 0.4778
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Onchocerca volvulus 0.0025 0.0036 0.0232
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0289 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0093 0.0937
Schistosoma mansoni neuropeptide F-like receptor 0.017 0.0485 0.7295
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0289 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0951
Trichomonas vaginalis esterase, putative 0.0038 0.0077 0.0736
Schistosoma mansoni biogenic amine receptor 0.017 0.0485 0.7295
Echinococcus multilocularis musashi 0.0025 0.0036 0.0017
Schistosoma mansoni opsin-like receptor 0.017 0.0485 0.7295
Echinococcus granulosus tumor protein p63 0.0314 0.0934 0.0917
Toxoplasma gondii ABC1 family protein 0.0038 0.0077 0.0889
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Onchocerca volvulus 0.0021 0.0024 0.0053
Brugia malayi 6-phosphofructokinase 0.0107 0.0289 0.3571
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0607
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0043 0.0093 0.0215
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0021 0.0002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.116
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0218 0.2521
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0077 0.0882
Brugia malayi nuclear hormone receptor 0.002 0.0021 0.0257
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0024 0.0016
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0289 0.4232
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0043 0.0093 0.0937
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0021 0.0002
Loa Loa (eye worm) neuropeptide F receptor 0.017 0.0485 0.5988
Echinococcus granulosus muscleblind protein 0.0147 0.0413 0.0395
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.017 0.0485 0.0467
Mycobacterium leprae Probable lipase LipE 0.0038 0.0077 0.1989
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.6843
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0366
Loa Loa (eye worm) hypothetical protein 0.0147 0.0413 0.51
Onchocerca volvulus 0.0072 0.0183 0.2466
Onchocerca volvulus Huntingtin homolog 0.0124 0.0342 0.488
Loa Loa (eye worm) hypothetical protein 0.01 0.0268 0.3305
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0021 0.0257
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0043 0.0093 0.0074
Schistosoma mansoni myosin xvIII 0.017 0.0485 0.7295
Onchocerca volvulus 0.0021 0.0024 0.0053
Loa Loa (eye worm) oxidoreductase 0.0021 0.0024 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0517 0.6298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0093 0.2588
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0048 0.1018
Echinococcus multilocularis g protein coupled receptor 0.017 0.0485 0.0467
Echinococcus granulosus neuropeptide FF receptor 2 0.017 0.0485 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Leishmania major hypothetical protein, conserved 0.0038 0.0077 0.0162
Toxoplasma gondii target of rapamycin (TOR), putative 0.0225 0.0658 1
Schistosoma mansoni ap endonuclease 0.002 0.002 0.0024
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0289 0.3571
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0951
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0127 0.0353 0.4357
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.002 0.0024
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0021 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0093 0.0937
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0046 0.0027
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.0036 0.0446
Echinococcus granulosus neuropeptides capa receptor 0.017 0.0485 0.0467
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0043 0.0093 0.116
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0024 0.03
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0126 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0043 0.0093 0.116
Echinococcus multilocularis G protein coupled receptor 139 0.017 0.0485 0.0467
Brugia malayi Serotonin/octopamine receptor family protein 7 0.017 0.0485 0.5988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0021 0.0257
Leishmania major phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.0207
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0183 0.2262
Loa Loa (eye worm) hypothetical protein 0.0054 0.0126 0.156
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0043 0.0093 0.116
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Leishmania major hypothetical protein, unknown function 0.0043 0.0093 0.0207
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0225 0.0658 0.1852
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0024 0.007
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0043 0.0093 0.1138
Brugia malayi sulfakinin receptor protein 0.017 0.0485 0.5988
Echinococcus granulosus rhodopsin orphan GPCR 0.017 0.0485 0.0467
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0043 0.0093 0.0937
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0117 0.1454
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0049 0.0476
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0951
Schistosoma mansoni biogenic amine (dopamine) receptor 0.017 0.0485 0.7295
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.017 0.0485 0.5988
Schistosoma mansoni amine GPCR 0.017 0.0485 0.7295
Entamoeba histolytica hypothetical protein 0.0072 0.0181 0.2538
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.081 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0074 0.0865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0048 0.043
Echinococcus granulosus tachykinin peptides receptor 99D 0.017 0.0485 0.0467
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0074 0.0843
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0024 0.0016
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0077 0.0736
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.017 0.0485 0.7295
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0183 0.5999
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.002 0.0024
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0019 0.0232
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0127 0.0353 0.0335
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0093 0.1147
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0043 0.0093 0.6843
Loa Loa (eye worm) hypothetical protein 0.0142 0.0398 0.4913
Brugia malayi G-protein coupled receptor 0.017 0.0485 0.5988
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0429
Echinococcus granulosus dro:myosuppressin receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0021 0.0257
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0183 0.6081
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0043 0.0093 0.0937
Echinococcus multilocularis GPCR, family 2 0.0046 0.0101 0.0083
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0127 0.0353 0.0968
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0043 0.0093 0.0074
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0021 0.0033
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0077 0.0058
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0021 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0021 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.0398 0.4792
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0077 0.0951
Echinococcus granulosus tm gpcr rhodopsin 0.017 0.0485 0.0467
Brugia malayi hypothetical protein 0.0124 0.0342 0.4225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Schistosoma mansoni neuropeptide receptor 0.017 0.0485 0.7295
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0021 0.0257
Schistosoma mansoni biogenic amine receptor 0.017 0.0485 0.7295
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0043 0.0093 0.0215
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0043 0.0093 0.0074
Onchocerca volvulus 0.0043 0.0093 0.1094
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0021 0.0257
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0093 0.116
Brugia malayi FAT domain containing protein 0.0098 0.0263 0.3251
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0021 0.0257
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0021 0.0257
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.017 0.0485 0.0467
Echinococcus multilocularis fmrfamide receptor 0.017 0.0485 0.0467
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0021 0.0002
Onchocerca volvulus 0.017 0.0485 0.7048
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0263 0.3091
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0074 1
Brugia malayi ORL1-like opioid receptor 0.017 0.0485 0.5988
Loa Loa (eye worm) phosphatidylinositol kinase 0.0043 0.0093 0.1147
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3235 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0077 0.2154
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0077 0.0736
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0127 0.0353 0.5227
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0024 0.0131
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Entamoeba histolytica hypothetical protein 0.0043 0.0093 0.116
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0021 0.0002
Schistosoma mansoni hypothetical protein 0.0046 0.0101 0.1294
Toxoplasma gondii FATC domain-containing protein 0.0127 0.0353 0.5216
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0289 0.4232
Onchocerca volvulus 0.0232 0.0679 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0093 0.1147
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0077 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0074 0.0865
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0024 0.0131
Schistosoma mansoni adenoreceptor 0.017 0.0485 0.7295
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0024 0.0087
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0077 0.0736
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0289 0.4232
Schistosoma mansoni thyroid hormone receptor 0.002 0.0021 0.0033
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0093 0.1147
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.017 0.0485 0.0467
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.116
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.017 0.0485 0.7048
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Schistosoma mansoni thyroid hormone receptor 0.002 0.0021 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0118 0.0324 0.4778
Schistosoma mansoni hypothetical protein 0.017 0.0485 0.7295
Brugia malayi beta-lactamase 0.0038 0.0077 0.0951
Schistosoma mansoni hypothetical protein 0.017 0.0485 0.7295
Loa Loa (eye worm) hypothetical protein 0.0054 0.0126 0.156
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Loa Loa (eye worm) hypothetical protein 0.0043 0.0093 0.1147
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.017 0.0485 0.0467
Schistosoma mansoni amine GPCR 0.017 0.0485 0.7295
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0043 0.0093 0.116
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0043 0.0093 0.116
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0183 0.2395
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.081 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0366
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0019 0.0232
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0183 0.6081
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0126 1
Schistosoma mansoni ap endonuclease 0.002 0.002 0.0024
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.116
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0289 0.3571
Onchocerca volvulus 0.017 0.0485 0.7048
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0289 0.3418
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0043 0.0093 0.0937
Schistosoma mansoni nuclear hormone receptor 0.002 0.0021 0.0033
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0951
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.002 0.0057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0951
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0126 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0024 0.007
Loa Loa (eye worm) hypothetical protein 0.0072 0.0183 0.2262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Onchocerca volvulus 0.017 0.0485 0.7048
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0024 0.0206
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0225 0.0658 0.1782
Leishmania major phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.0207
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0289 0.3571
Schistosoma mansoni hypothetical protein 0.0098 0.0263 0.3826
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0019 0.0232
Echinococcus multilocularis tumor protein p63 0.0314 0.0934 0.0917
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.0215
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.017 0.0485 0.0467
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0021 0.0033
Echinococcus granulosus G protein coupled receptor 139 0.017 0.0485 0.0467
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.0658 0.8123
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0043 0.0093 0.0215
Echinococcus multilocularis tachykinin peptides receptor 99D 0.017 0.0485 0.0467
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0024 0.0131
Echinococcus multilocularis biogenic amine (5HT) receptor 0.017 0.0485 0.0467
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0077 0.5347
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.017 0.0485 0.7295
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0142 0.0398 0.5932
Mycobacterium ulcerans hypothetical protein 0.0038 0.0077 0.2154
Brugia malayi larval opioid receptor 0.017 0.0485 0.5988
Schistosoma mansoni tar DNA-binding protein 0.0118 0.0324 0.4778
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0024 0.0131
Loa Loa (eye worm) intermediate filament protein 0.0025 0.0036 0.0446
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0183 0.6081
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.0215
Echinococcus multilocularis neuropeptide Y receptor 0.017 0.0485 0.0467
Brugia malayi Serotonin receptor 0.017 0.0485 0.5988
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0077 0.0911
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0117 0.1454
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0077 0.1989
Schistosoma mansoni intermediate filament proteins 0.0025 0.0036 0.0272
Schistosoma mansoni hypothetical protein 0.0046 0.0101 0.1294
Schistosoma mansoni tar DNA-binding protein 0.0118 0.0324 0.4778
Brugia malayi hypothetical protein 0.017 0.0485 0.5988
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0024 0.0131
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0289 0.0271
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0093 0.6843
Brugia malayi putative neuropeptide receptor NPR1 0.017 0.0485 0.5988
Echinococcus granulosus serine protein kinase ATM 0.0127 0.0353 0.0335
Entamoeba histolytica hypothetical protein 0.0072 0.0181 0.2538
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0274 0.081 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0024 0.03
Echinococcus multilocularis sex peptide receptor 0.017 0.0485 0.0467
Echinococcus granulosus g protein coupled receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0024 0.03
Onchocerca volvulus 0.017 0.0485 0.7048
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.0658 0.8123
Entamoeba histolytica hypothetical protein 0.0072 0.0181 0.2538
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0024 0.0131
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0074 0.0699
Schistosoma mansoni growth hormone secretagogue receptor 0.017 0.0485 0.7295
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0048 0.043
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0084 0.0218 0.0578
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0021 0.0002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.0093 0.116
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0225 0.0658 0.1782
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.081 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0021 0.0002
Schistosoma mansoni biogenic amine receptor 0.017 0.0485 0.7295
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0043 0.0093 0.116
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0117 0.1454
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0049 0.003
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0289 0.3418
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0127 0.0353 0.5227
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trichomonas vaginalis ap endonuclease, putative 0.002 0.002 0.0019
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0043 0.0093 0.0074
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0074 0.0699
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0225 0.0658 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0024 0.0206
Schistosoma mansoni hypothetical protein 0.0072 0.0181 0.2538
Schistosoma mansoni opsin-like receptor 0.017 0.0485 0.7295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0074 0.2044
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0048 0.2582
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0021 0.0257
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0024 0.0206
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0021 0.0033
Onchocerca volvulus 0.0021 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.0147 0.0413 0.51
Echinococcus granulosus g protein coupled receptor 0.017 0.0485 0.0467
Schistosoma mansoni hypothetical protein 0.0043 0.0093 0.116
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0225 0.0658 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0077 0.0882
Loa Loa (eye worm) hypothetical protein 0.0072 0.0183 0.2262
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0289 0.0754
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.0101 0.1288
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0021 0.0257
Brugia malayi neuropeptide F receptor 0.017 0.0485 0.5988
Echinococcus multilocularis neuropeptide receptor 0.017 0.0485 0.0467
Brugia malayi Dopamine receptor protein 1 0.017 0.0485 0.5988
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0043 0.0093 0.1147
Mycobacterium ulcerans hypothetical protein 0.0072 0.0183 0.6081
Echinococcus multilocularis serine protein kinase ATM 0.0127 0.0353 0.0335
Echinococcus multilocularis muscleblind protein 0.0147 0.0413 0.0395
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0127 0.0353 0.5227
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0024 0.0131
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0048 0.2582
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0183 0.0459
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0024 0.0206
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.002 0.0251
Loa Loa (eye worm) hypothetical protein 0.0046 0.0101 0.1248
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.081 1
Onchocerca volvulus 0.017 0.0485 0.7048
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0181 0.0163
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0183 0.6081
Mycobacterium ulcerans beta-lactamase 0.0038 0.0077 0.2154
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0021 0.0033
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0093 0.1147
Trypanosoma cruzi target of rapamycin kinase 3 0.0225 0.0658 0.1852
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0077 0.0882
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0289 0.3418
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0043 0.0093 0.0074
Onchocerca volvulus 0.017 0.0485 0.7048
Onchocerca volvulus 0.017 0.0485 0.7048
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0062 0.1419
Schistosoma mansoni neuropeptide F-like receptor 0.017 0.0485 0.7295
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.002 0.0002
Brugia malayi 6-phosphofructokinase 0.0107 0.0289 0.3571
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0048 0.0366
Onchocerca volvulus 0.017 0.0485 0.7048
Echinococcus granulosus 7tm_1 domain containing protein 0.017 0.0485 0.0467
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0183 0.6081
Brugia malayi gonadotropin-releasing hormone receptor 2 0.017 0.0485 0.5988
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0021 0.0002
Brugia malayi G-protein coupled receptor 0.017 0.0485 0.5988
Brugia malayi Dopamine receptor 0.017 0.0485 0.5988
Echinococcus granulosus neuropeptide receptor 0.017 0.0485 0.0467
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.0717 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0021 0.0257
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0062 0.0666
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0517 0.6298
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Loa Loa (eye worm) melatonin receptor type 1A 0.017 0.0485 0.5988
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.017 0.0485 0.5988
Schistosoma mansoni rhodopsin-like orphan GPCR 0.017 0.0485 0.7295
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0024 0.0016
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0043 0.0093 0.116
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0043 0.0093 0.6843
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0043 0.0093 0.1138
Echinococcus granulosus g-protein coupled receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.0658 0.8123
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.017 0.0485 0.5988
Loa Loa (eye worm) G-protein coupled receptor 0.017 0.0485 0.5988
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0024 0.0206
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0127 0.0353 0.4357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.017 0.0485 0.7295
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0093 0.1147
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Loa Loa (eye worm) hypothetical protein 0.0124 0.0342 0.4225
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0077 0.0882
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0225 0.0658 1
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0101 0.1253
Onchocerca volvulus Neuropeptide F receptor homolog 0.017 0.0485 0.7048
Loa Loa (eye worm) hypothetical protein 0.0054 0.0126 0.156
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0074 0.0055
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.017 0.0485 0.0467
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Echinococcus multilocularis serotonin receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0049 0.003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0021 0.0257
Echinococcus granulosus neuropeptide receptor 0.017 0.0485 0.0467
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.002 0.0004
Brugia malayi phosphofructokinase 0.0107 0.0289 0.3571
Brugia malayi putative neuropeptide receptor 0.017 0.0485 0.5988
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0043 0.0093 0.1138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Onchocerca volvulus 0.0021 0.0024 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0021 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0021 0.0257
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0021 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0517 0.6298
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0021 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.1131 0.347 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0127 0.0353 0.5227
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0043 0.0093 0.0074
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0043 0.0093 0.116
Brugia malayi Pre-SET motif family protein 0.0204 0.0592 0.7308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0127 0.0353 0.4223
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.002 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.017 0.0485 0.0467
Schistosoma mansoni biogenic amine (5HT) receptor 0.017 0.0485 0.7295
Entamoeba histolytica hypothetical protein 0.0072 0.0181 0.2538
Echinococcus multilocularis neuropeptide s receptor 0.017 0.0485 0.0467
Echinococcus multilocularis g protein coupled receptor 0.017 0.0485 0.0467
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0024 0.0206
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0101 0.0083
Onchocerca volvulus 0.017 0.0485 0.7048
Leishmania major phosphatidylinositol 3-kinase, putative 0.0225 0.0658 0.1782
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.017 0.0485 0.7295
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0043 0.0093 0.0937
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.017 0.0485 0.0467
Echinococcus multilocularis lamin dm0 0.0025 0.0036 0.0017
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0225 0.0658 0.1782
Echinococcus multilocularis g-protein coupled receptor 0.017 0.0485 0.0467
Brugia malayi Serotonin receptor 0.017 0.0485 0.5988
Schistosoma mansoni inositol monophosphatase 0.0037 0.0074 0.0865
Loa Loa (eye worm) hypothetical protein 0.0124 0.0342 0.4225
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0127 0.0353 0.0968
Loa Loa (eye worm) TYRA-2 protein 0.017 0.0485 0.5988
Trichomonas vaginalis set domain proteins, putative 0.0232 0.0679 0.8351
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0101 0.0083
Brugia malayi Pre-SET motif family protein 0.0029 0.0049 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0142 0.0398 0.4792
Echinococcus multilocularis allatostatin A receptor 0.017 0.0485 0.0467
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0043 0.0093 0.0207
Echinococcus granulosus rhodopsin orphan GPCR 0.017 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.0054 0.0126 0.156
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.017 0.0485 0.5988
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0289 0.0271
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0043 0.0093 0.116
Loa Loa (eye worm) hypothetical protein 0.017 0.0485 0.5988
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0048 0.0453
Mycobacterium tuberculosis Conserved protein 0.0038 0.0077 0.0882
Echinococcus granulosus g protein coupled receptor 0.017 0.0485 0.0467
Loa Loa (eye worm) follicle stimulating hormone receptor 0.017 0.0485 0.5988
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0043 0.0093 0.6843
Echinococcus granulosus tm gpcr rhodopsin 0.017 0.0485 0.0467
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0024 0.0131
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0658 0.8078
Echinococcus granulosus hypothetical protein 0.017 0.0485 0.0467
Brugia malayi Inositol-1 0.0037 0.0074 0.0914
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0225 0.0658 0.064
Echinococcus granulosus lamin 0.0025 0.0036 0.0017
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0021 0.0257
Loa Loa (eye worm) hypothetical protein 0.0127 0.0353 0.4357
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0225 0.0658 0.064
Schistosoma mansoni histamine h1 receptor 0.017 0.0485 0.7295
Schistosoma mansoni amine GPCR 0.017 0.0485 0.7295
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0024 0.0206

Activities

Activity type Activity value Assay description Source Reference
Drug uptake (ADMET) = 0.06 % ID/g Biodistribution in Sprague-Dawley rat blood at 15 uCi, iv after 120 mins ChEMBL. 17696417
Drug uptake (ADMET) = 0.06 % ID/g Biodistribution in Sprague-Dawley rat muscle at 15 uCi, iv after 30 mins ChEMBL. 17696417
Drug uptake (ADMET) = 0.09 % ID/g Biodistribution in Sprague-Dawley rat spleen at 15 uCi, iv after 120 mins ChEMBL. 17696417
Drug uptake (ADMET) = 0.09 % ID/g Biodistribution in Sprague-Dawley rat muscle at 15 uCi, iv after 120 mins ChEMBL. 17696417
Drug uptake (ADMET) = 0.11 % ID/g Biodistribution in Sprague-Dawley rat blood at 15 uCi, iv after 30 mins ChEMBL. 17696417
Drug uptake (ADMET) = 0.12 % ID/g Biodistribution in Sprague-Dawley rat lung at 15 uCi, iv after 120 mins ChEMBL. 17696417
Drug uptake (ADMET) = 0.17 % ID/g Biodistribution in Sprague-Dawley rat brain at 15 uCi, iv after 120 mins ChEMBL. 17696417
Drug uptake (ADMET) = 0.26 % ID/g Biodistribution in Sprague-Dawley rat brain at 15 uCi, iv after 30 mins ChEMBL. 17696417
Drug uptake (ADMET) = 0.32 % ID/g Biodistribution in Sprague-Dawley rat lung at 15 uCi, iv after 30 mins ChEMBL. 17696417
Drug uptake (ADMET) = 0.36 % ID/g Biodistribution in Sprague-Dawley rat femur at 15 uCi, iv after 30 mins ChEMBL. 17696417
Drug uptake (ADMET) = 0.41 % ID/g Biodistribution in Sprague-Dawley rat spleen at 15 uCi, iv after 30 mins ChEMBL. 17696417
Drug uptake (ADMET) = 0.59 % ID/g Biodistribution in Sprague-Dawley rat kidney at 15 uCi, iv after 120 mins ChEMBL. 17696417
Drug uptake (ADMET) = 0.6 % ID/g Biodistribution in Sprague-Dawley rat liver at 15 uCi, iv after 120 mins ChEMBL. 17696417
Drug uptake (ADMET) = 0.74 % ID/g Biodistribution in Sprague-Dawley rat femur at 15 uCi, iv after 120 mins ChEMBL. 17696417
Drug uptake (ADMET) = 1.52 % ID/g Biodistribution in Sprague-Dawley rat heart at 15 uCi, iv after 120 mins ChEMBL. 17696417
Drug uptake (ADMET) = 1.93 % ID/g Biodistribution in Sprague-Dawley rat kidney at 15 uCi, iv after 30 mins ChEMBL. 17696417
Drug uptake (ADMET) = 2 % ID/g Biodistribution in Sprague-Dawley rat liver at 15 uCi, iv after 30 mins ChEMBL. 17696417
Drug uptake (ADMET) = 2.24 % ID/g Biodistribution in Sprague-Dawley rat heart at 15 uCi, iv after 30 mins ChEMBL. 17696417

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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