Detailed information for compound 433721

Basic information

Technical information
  • TDR Targets ID: 433721
  • Name: ditert-butyl 2-[4-[4-[[1,3-bis[(2-methylpropa n-2-yl)oxycarbonyl]imidazolidin-2-ylidene]ami no]phenoxy]phenyl]iminoimidazolidine-1,3-dica rboxylate
  • MW: 736.854 | Formula: C38H52N6O9
  • H donors: 0 H acceptors: 4 LogP: 6.98 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N1CCN(C1=Nc1ccc(cc1)Oc1ccc(cc1)N=C1N(CCN1C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)OC(C)(C)C
  • InChi: 1S/C38H52N6O9/c1-35(2,3)50-31(45)41-21-22-42(32(46)51-36(4,5)6)29(41)39-25-13-17-27(18-14-25)49-28-19-15-26(16-20-28)40-30-43(33(47)52-37(7,8)9)23-24-44(30)34(48)53-38(10,11)12/h13-20H,21-24H2,1-12H3
  • InChiKey: SBTTYTAIXKTOET-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ditert-butyl 2-[4-[4-[[1,3-bis(tert-butoxycarbonyl)imidazolidin-2-ylidene]amino]phenoxy]phenyl]iminoimidazolidine-1,3-dicarboxylate
  • 2-[4-[4-[[1,3-bis[tert-butoxy(oxo)methyl]-2-imidazolidinylidene]amino]phenoxy]phenyl]iminoimidazolidine-1,3-dicarboxylic acid ditert-butyl ester
  • 2-[4-[4-[[1,3-bis(tert-butoxycarbonyl)imidazolidin-2-ylidene]amino]phenoxy]phenyl]iminoimidazolidine-1,3-dicarboxylic acid ditert-butyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.0328 0.4259
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0075 0.0976
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0109 0.0246 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0003 0.0042
Echinococcus multilocularis tyrosine protein kinase Srms 0.0054 0.0092 0.0092
Echinococcus granulosus TGF beta receptor type 1 0.0088 0.0188 0.0188
Echinococcus multilocularis peptidase Clp (S14 family) 0.0059 0.0107 0.0107
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0113 0.1625
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0046 0.0069 0.0069
Echinococcus multilocularis MAM 0.0032 0.0029 0.0029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0075 0.0976
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0048 0.0075 0.1029
Echinococcus multilocularis cyclin dependent kinase 7 0.0094 0.0204 0.0204
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0075 0.1029
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0036 0.0042 0.0545
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0089 0.1167
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0059 0.0107 1
Toxoplasma gondii casein kinase I 0.005 0.0081 0.1129
Brugia malayi Protein kinase domain containing protein 0.0196 0.0488 0.6341
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0025 0.001 0.001
Giardia lamblia GTOR 0.0251 0.0641 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0048 0.0075 0.1029
Schistosoma mansoni tyrosine kinase 0.0032 0.0031 0.0405
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0048 0.0075 0.0163
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0062 0.0113 0.0113
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0048 0.0075 0.1172
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0109 0.0246 0.0246
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0071 0.0139 0.2168
Schistosoma mansoni tyrosine kinase 0.0082 0.0168 0.2215
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.0381 0.5872
Loa Loa (eye worm) phosphatidylinositol kinase 0.0048 0.0075 0.0976
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0182 0.0448 0.0448
Echinococcus multilocularis protein tyrosine kinase 0.0293 0.076 0.076
Brugia malayi protein-tyrosine kinase 0.0054 0.0092 0.1192
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0003 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Schistosoma mansoni growth factor receptor-bound protein 0.0024 0.0008 0.0101
Schistosoma mansoni protein kinase 0.005 0.0081 0.1071
Echinococcus granulosus tyrosine kinase 0.0054 0.0092 0.0092
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0085 0.0178 0.2317
Echinococcus multilocularis c src tyrosine kinase 0.0032 0.0031 0.0031
Brugia malayi Protein kinase domain 0.0026 0.0012 0.0157
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0048 0.0075 0.1029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0141 0.0336 0.436
Entamoeba histolytica protein kinase, putative 0.0026 0.0012 0.0188
Giardia lamblia Kinase, CMGC CLK 0.0076 0.0152 0.2221
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0025 0.001 0.001
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0075 0.1029
Plasmodium vivax glycogen synthase kinase 3, putative 0.0062 0.0113 0.5575
Entamoeba histolytica protein kinase, putative 0.0026 0.0012 0.0188
Schistosoma mansoni protein kinase 0.0088 0.0188 0.2468
Plasmodium falciparum serine/threonine protein kinase, putative 0.0071 0.0139 0.7006
Leishmania major phosphatidylinositol kinase, putative 0.0048 0.0075 0.0181
Giardia lamblia Aurora kinase 0.0071 0.0139 0.2018
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0048 0.0075 0.3531
Onchocerca volvulus 0.005 0.0081 0.1759
Onchocerca volvulus 0.0048 0.0075 0.1623
Onchocerca volvulus 0.0028 0.0019 0.0415
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0187 0.0463 0.6016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0213 0.0537 0.6977
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Toxoplasma gondii hypothetical protein 0.0031 0.0028 0.0278
Echinococcus granulosus tyrosine protein kinase Src42A 0.0065 0.0123 0.0123
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0194 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0251 0.0641 1
Brugia malayi protein C17H12.11 0.0068 0.0132 0.1713
Brugia malayi FAT domain containing protein 0.0109 0.0246 0.3195
Trypanosoma cruzi target of rapamycin kinase 3 0.0251 0.0641 0.1808
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0025 0.001 0.001
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0075 0.0075
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0102 0.1326
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0003 0.0042
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0048 0.0075 0.3531
Echinococcus multilocularis dual specificity protein kinase clk2 0.0076 0.0152 0.0152
Echinococcus granulosus cyclin dependent kinase 19 0.0155 0.0373 0.0373
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0251 0.0641 0.1808
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.005 0.0081 0.1058
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0048 0.0075 0.1029
Onchocerca volvulus Huntingtin homolog 0.0142 0.0338 0.7299
Echinococcus multilocularis activin receptor type 0.0428 0.1138 0.1138
Echinococcus multilocularis 0.0048 0.0075 0.0075
Onchocerca volvulus 0.0042 0.0059 0.1268
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0138 0.0325 0.0325
Echinococcus granulosus mitogen activated protein kinase 11 0.0149 0.0358 0.0358
Brugia malayi serine/threonine-protein kinase 6 0.0071 0.0139 0.1806
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0045 0.0066 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0022 0.0003 0.0035
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0094 0.0204 0.2648
Plasmodium vivax casein kinase 1, putative 0.005 0.0081 0.3873
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0065 0.0123 0.0123
Leishmania major phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.0181
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.3531
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0026 0.0012 0.0012
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0036 0.0042 0.0042
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0194 0.2914
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0141 0.0336 0.092
Onchocerca volvulus 0.0077 0.0156 0.336
Trichomonas vaginalis STE family protein kinase 0.0026 0.0012 0.003
Entamoeba histolytica protein kinase, putative 0.0071 0.0139 0.2168
Loa Loa (eye worm) TK/FAK protein kinase 0.0297 0.077 1
Schistosoma mansoni hypothetical protein 0.0048 0.0075 0.0988
Echinococcus multilocularis mitogen activated protein kinase 14 0.0149 0.0358 0.0358
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0075 0.1029
Trichomonas vaginalis CK1 family protein kinase 0.005 0.0081 0.1129
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0152 0.1997
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.005 0.0081 0.1058
Trichomonas vaginalis STE family protein kinase 0.0026 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0081 0.0166 0.2161
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.1172
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3597 1 1
Brugia malayi Probable ClpP-like protease 0.0091 0.0194 0.2522
Entamoeba histolytica protein kinase domain containing protein 0.0071 0.0139 0.2168
Loa Loa (eye worm) hypothetical protein 0.0048 0.0075 0.0976
Loa Loa (eye worm) TK protein kinase 0.0054 0.0092 0.1192
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0139 0.1806
Brugia malayi Sex muscle abnormal protein 5 0.0022 0.0003 0.0034
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0155 0.0373 0.485
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0075 0.1029
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0102 0.1326
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0066 0.0864
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0267 0.0687 0.8922
Trichomonas vaginalis STE family protein kinase 0.0026 0.0012 0.003
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0075 0.0163
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0641 0.8331
Schistosoma mansoni fkbp-rapamycin associated protein 0.0141 0.0336 0.4414
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0045 0.0066 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0139 0.2042
Brugia malayi casein kinase 1, delta 0.005 0.0081 0.1058
Leishmania major protein kinase, putative 0.0076 0.0152 0.0395
Onchocerca volvulus 0.0081 0.0166 0.3592
Schistosoma mansoni vam6/vps39 related 0.0028 0.0019 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0121 0.0279 0.0279
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0124 0.0288 0.3737
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0157 0.0381 0.5872
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0036 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.025
Schistosoma mansoni hypothetical protein 0.0032 0.0029 0.038
Loa Loa (eye worm) hypothetical protein 0.0068 0.0132 0.1712
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0048 0.0075 0.0075
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.1172
Schistosoma mansoni peptidase Clp (S14 family) 0.0091 0.0194 0.2553
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0062 0.0113 0.1625
Plasmodium falciparum protein serine/threonine kinase-1 0.0076 0.0152 0.7699
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0075 0.1029
Giardia lamblia Hypothetical protein 0.0048 0.0075 0.1002
Trypanosoma cruzi casein kinase, putative 0.005 0.0081 0.0181
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0065 0.0123 0.0123
Echinococcus granulosus tyrosine protein kinase Blk 0.0054 0.0092 0.0092
Echinococcus multilocularis protein kinase shaggy 0.0062 0.0113 0.0113
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0194 0.5
Brugia malayi Protein kinase domain containing protein 0.0275 0.0709 0.9207
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0048 0.0075 0.1029
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0048 0.0075 0.0988
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0075 0.1029
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0048 0.0075 0.0988
Leishmania major protein kinase, putative 0.0076 0.0152 0.0395
Echinococcus granulosus growth factor receptor bound protein 2 0.0024 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0048 0.0075 0.1172
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0251 0.0641 0.1808
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0048 0.0075 0.0075
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0076 0.0152 0.0385
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0076 0.0152 0.2244
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0376
Schistosoma mansoni hypothetical protein 0.0109 0.0246 0.3235
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0376
Echinococcus granulosus tyrosine protein kinase Fyn 0.0065 0.0123 0.0123
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0251 0.0641 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0251 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0661
Brugia malayi P38 map kinase family protein 2 0.0149 0.0358 0.4648
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0251 0.0641 0.1761
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0075 0.1029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0075 0.0976
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0187 0.0463 0.6016
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0062 0.0113 0.1483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0025 0.001 0.001
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0075 0.1029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0075 0.0976
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.005 0.0081 0.1058
Brugia malayi SRC-1 0.0065 0.0123 0.1592
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0077 0.0154 0.2008
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0076 0.0152 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0048 0.0075 0.0988
Echinococcus multilocularis Zinc finger, PHD finger 0.0048 0.0075 0.0075
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0149 0.0358 0.4648
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0149 0.0358 0.0984
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0028 0.0019 0.0253
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0251 0.0641 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0275 0.0708 0.9204
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0463 0.609
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0048 0.0075 0.0163
Brugia malayi casein kinase I 0.005 0.0081 0.1058
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0026 0.0012 0.0012
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.0113 0.1465
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0089 0.1167
Echinococcus granulosus cyclin dependent kinase 7 0.0094 0.0204 0.0204
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0025 0.001 0.0132
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0113 0.1758
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0194 0.5
Entamoeba histolytica protein kinase, putative 0.0025 0.001 0.0159
Trypanosoma cruzi casein kinase, delta isoform, putative 0.005 0.0081 0.0181
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0139 0.2042
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0048 0.0075 0.0075
Onchocerca volvulus 0.0032 0.0029 0.0624
Entamoeba histolytica protein kinase, putative 0.0025 0.001 0.0159
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0048 0.0075 0.0976
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0065 0.0123 0.0123
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0194 0.5
Trypanosoma cruzi casein kinase, putative 0.005 0.0081 0.0181
Entamoeba histolytica hypothetical protein 0.0048 0.0075 0.1172
Loa Loa (eye worm) hypothetical protein 0.0068 0.0132 0.1712
Giardia lamblia Kinase, CMGC GSK 0.0062 0.0113 0.16
Loa Loa (eye worm) hypothetical protein 0.0058 0.0102 0.1326
Schistosoma mansoni hypothetical protein 0.004 0.0051 0.0669
Echinococcus granulosus casein kinase I delta 0.005 0.0081 0.0081
Echinococcus granulosus aurora kinase A 0.0071 0.0139 0.0139
Toxoplasma gondii FATC domain-containing protein 0.0141 0.0336 0.5157
Brugia malayi Protein kinase domain containing protein 0.0297 0.077 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0048 0.0075 0.0075
Echinococcus granulosus peptidase Clp S14 family 0.0059 0.0107 0.0107
Echinococcus multilocularis TGF beta receptor type 1 0.0088 0.0188 0.0188
Echinococcus multilocularis serine protein kinase ATM 0.0141 0.0336 0.0336
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0025 0.001 0.0132
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0267 0.0687 0.0687
Giardia lamblia Phosphatidylinositol 4-kinase 0.0048 0.0075 0.1002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.1172
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.1029
Echinococcus multilocularis mitogen activated protein kinase 11 0.0149 0.0358 0.0358
Entamoeba histolytica casein kinase 1, putative 0.005 0.0081 0.127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0065 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0157 0.0381 0.4947
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0141 0.0336 0.4414
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0048 0.0075 0.1002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0187 0.0463 0.6016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0251 0.0641 0.1761
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0089 0.1167
Loa Loa (eye worm) hypothetical protein 0.0093 0.0201 0.2608
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0075 0.1029
Brugia malayi serine/threonine protein kinase 6 0.0071 0.0139 0.1806
Schistosoma mansoni protein kinase 0.009 0.0193 0.2539
Echinococcus multilocularis cyclin dependent kinase 19 0.0155 0.0373 0.0373
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0026 0.0012 0.0012
Echinococcus granulosus dual specificity protein kinase clk2 0.0076 0.0152 0.0152
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0048 0.0075 0.1172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0187 0.0463 0.0463
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0139 0.2042
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0139 0.1829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Trypanosoma cruzi casein kinase, putative 0.005 0.0081 0.0181
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0065 0.0123 0.0123
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0139 0.2042
Echinococcus multilocularis tyrosine protein kinase Blk 0.0054 0.0092 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0022 0.0003 0.0003
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0075 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0075 0.1029
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0065 0.0123 0.0123
Trichomonas vaginalis CK1 family protein kinase 0.005 0.0081 0.1129
Schistosoma mansoni protein kinase 0.0149 0.0358 0.4703
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0091 0.0194 0.5
Echinococcus granulosus serine protein kinase ATM 0.0141 0.0336 0.0336
Leishmania major hypothetical protein, unknown function 0.0048 0.0075 0.0181
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0076 0.0152 0.0385
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0077 0.0155 0.2008
Loa Loa (eye worm) hypothetical protein 0.0072 0.014 0.1823
Entamoeba histolytica protein kinase, putative 0.0043 0.006 0.0938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Giardia lamblia Kinase, CK1 Casein kinase 0.005 0.0081 0.1102
Brugia malayi C1-like domain containing protein 0.0085 0.0178 0.2317
Brugia malayi hypothetical protein 0.022 0.0555 0.7213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Loa Loa (eye worm) hypothetical protein 0.0233 0.0592 0.7687
Schistosoma mansoni tyrosine kinase 0.0028 0.0017 0.023
Echinococcus multilocularis death associated protein kinase 1 0.092 0.2514 0.2514
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0054 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.025
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0139 0.1806
Echinococcus multilocularis casein kinase I alpha 0.005 0.0081 0.0081
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0071 0.0139 0.0139
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0124 0.0288 0.3737
Onchocerca volvulus 0.0048 0.0075 0.1623
Trichomonas vaginalis CMGC family protein kinase 0.0076 0.0152 0.2244
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0048 0.0075 0.0988
Loa Loa (eye worm) TK protein kinase 0.0124 0.0288 0.3741
Brugia malayi Protein kinase domain containing protein 0.0077 0.0155 0.2008
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0194 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 0.0129 0.1677
Echinococcus granulosus c-Jun N-terminal kinases 0.0267 0.0687 0.0687
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0062 0.0113 0.0272
Loa Loa (eye worm) hypothetical protein 0.0186 0.046 0.5973
Brugia malayi serine/threonine-protein kinase PAK 7 0.0213 0.0537 0.6977
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.0373 0.491
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0085 0.0178 0.2317
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0036 0.0042 0.0042
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0051 0.0661
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0138 0.0325 0.4221
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0088 0.0188 0.0188
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0251 0.0641 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0149 0.0358 0.0358
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0048 0.0075 0.1029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0089 0.1153
Giardia lamblia Kinase, CMGC GSK 0.0062 0.0113 0.16
Brugia malayi Protein kinase domain containing protein 0.0196 0.0488 0.6339
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0089 0.0089
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0251 0.0641 0.0641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0075 0.3531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0157 0.0381 0.5872
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0121 0.0279 0.0279
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.1172
Echinococcus granulosus activated cdc42 kinase 1 0.0196 0.0488 0.0488
Echinococcus granulosus hypothetical protein 0.0068 0.0129 0.0129
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0251 0.0641 0.1808
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0139 0.1806
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0048 0.0635
Schistosoma mansoni tyrosine kinase 0.0293 0.076 1
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0003 0.0034
Brugia malayi Temporarily assigned gene name protein 59 0.0028 0.0019 0.025
Plasmodium vivax hypothetical protein 0.0048 0.0075 0.3531
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0075 0.0976
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0194 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0093 0.0201 0.0528
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0251 0.0641 0.8435
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0251 0.0641 0.0641
Echinococcus granulosus tyrosine protein kinase HCK 0.0043 0.006 0.006
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0121 0.0279 0.0279
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0076 0.0152 0.2244
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0201 0.302
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0641 0.8331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Echinococcus multilocularis PAK box P21 Rho binding 0.0026 0.0012 0.0012
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0075 0.0075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0089 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.0163
Onchocerca volvulus Huntingtin homolog 0.0142 0.0338 0.7299
Leishmania major phosphatidylinositol kinase related protein, putative 0.0048 0.0075 0.0181
Loa Loa (eye worm) hypothetical protein 0.0091 0.0194 0.2522
Plasmodium vivax serine/threonine kinase-1, putative 0.0076 0.0152 0.7699
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0065 0.0123 0.0123
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.1029
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0076 0.0152 0.1972
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0204 0.2681
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0075 0.1029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0028 0.0019 0.0143
Echinococcus granulosus casein kinase i 0.005 0.0081 0.0081
Schistosoma mansoni protein kinase C mu 0.0085 0.0178 0.2345
Leishmania major casein kinase, putative 0.005 0.0081 0.0199
Entamoeba histolytica protein kinase, putative 0.0062 0.0113 0.1758
Trichomonas vaginalis STE family protein kinase 0.0026 0.0012 0.003
Schistosoma mansoni rap gtpase-activating protein 0.0028 0.0019 0.0253
Echinococcus granulosus casein kinase I alpha 0.005 0.0081 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.0488 0.6419
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0092 0.0092
Brugia malayi Protein kinase domain containing protein 0.0155 0.0373 0.485
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0048 0.0075 0.0988
Trypanosoma cruzi casein kinase, putative 0.005 0.0081 0.0181
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0152 0.1997
Echinococcus multilocularis NCK adaptor protein 0.0024 0.0008 0.0008
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0025 0.001 0.001
Onchocerca volvulus 0.0068 0.0132 0.2847
Loa Loa (eye worm) TK protein kinase 0.0043 0.006 0.0782
Entamoeba histolytica protein kinase, putative 0.003 0.0023 0.0356
Loa Loa (eye worm) hypothetical protein 0.0141 0.0336 0.436
Echinococcus multilocularis tyrosine protein kinase HCK 0.0043 0.006 0.006
Leishmania major phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.0181
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0042 0.0059 0.0115
Onchocerca volvulus 0.0032 0.0029 0.0624
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0075 0.0075
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0149 0.0358 0.5508
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0028 0.0019 0.0019
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0077 0.0155 0.2008
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0152 0.0365 0.4743
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0091 0.0194 0.0194
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.022 0.0555 0.7213
Loa Loa (eye worm) gastrulation defective protein 1 0.0147 0.035 0.4555
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0005 0.0065
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0113 0.1625
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0065 0.0123 0.0123
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0196 0.0488 0.6341
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0065 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Brugia malayi hypothetical protein 0.0028 0.0019 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.0246 0.3735
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0048 0.0075 0.3531
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0075 0.0976
Brugia malayi hypothetical protein 0.0068 0.0132 0.1713
Brugia malayi Immunoglobulin I-set domain containing protein 0.0124 0.0288 0.3741
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0071 0.0139 0.2168
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0026 0.0012 0.0012
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0048 0.0075 0.0976
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0076 0.0152 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0338 0.4391
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0149 0.0358 0.0984
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0141 0.0336 0.0336
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.0113 0.1465
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0032 0.0031 0.0405
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0141 0.0336 0.0336
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0251 0.0641 0.1761
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0641 0.8331
Brugia malayi Serine/threonine-protein kinase SULU 0.022 0.0555 0.7213
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0095 0.0207 0.0207
Echinococcus granulosus tyrosine protein kinase Lyn 0.0073 0.0145 0.0145
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0048 0.0075 0.1002
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0048 0.0075 0.0988
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.1172
Leishmania major protein kinase, putative 0.0071 0.0139 0.0359
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0251 0.0641 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Toxoplasma gondii target of rapamycin (TOR), putative 0.0251 0.0641 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.025
Brugia malayi serine/threonine kinase 12 0.0071 0.0139 0.1806
Brugia malayi Protein kinase domain containing protein 0.0076 0.0152 0.1972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0075 0.0976
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0089 0.1153
Plasmodium falciparum casein kinase 1 0.005 0.0081 0.3873
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0028 0.0019 0.0253
Trypanosoma cruzi hypothetical protein, conserved 0.1258 0.3459 1
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0062 0.0113 0.0113
Echinococcus granulosus protein kinase 0.0075 0.0151 0.0151
Echinococcus multilocularis casein kinase I alpha 0.005 0.0081 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.001 0.0134
Echinococcus granulosus casein kinase I alpha 0.005 0.0081 0.0081
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.3531
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0149 0.0358 0.0358
Echinococcus granulosus mitogen activated protein kinase 14 0.0149 0.0358 0.0358
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0048 0.0075 0.1029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Echinococcus granulosus protein kinase shaggy 0.0062 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0028 0.0019 0.0253
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0091 0.0194 0.0194
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0028 0.0953
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0048 0.0075 0.3531
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0251 0.0641 0.1808
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0028 0.0953
Echinococcus granulosus NCK adaptor protein 0.0022 0.0003 0.0003
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0026 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0338 0.4391
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0152 0.0365 0.4743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0048 0.0075 0.1029
Echinococcus granulosus activated cdc42 kinase 1 0.0196 0.0488 0.0488
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.022 0.0555 0.0555
Echinococcus granulosus TGF-beta receptor type-1 0.0088 0.0188 0.0188
Brugia malayi hypothetical protein 0.0142 0.0338 0.4391
Schistosoma mansoni protein kinase 0.0036 0.0042 0.0552
Brugia malayi cyclin-dependent kinase 7 homolog 0.0094 0.0204 0.2648
Echinococcus multilocularis 0.0075 0.0151 0.0151
Brugia malayi probable protein kinase 0.0104 0.023 0.2988
Entamoeba histolytica protein kinase , putative 0.0071 0.0139 0.2168
Brugia malayi Tyrosine-protein kinase abl-1 0.0032 0.0031 0.04
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0003 0.0042
Entamoeba histolytica hypothetical protein 0.0048 0.0075 0.1172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Trypanosoma brucei protein kinase, putative 0.0062 0.0113 0.1625
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0141 0.0336 0.5157
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0048 0.0075 0.0163
Echinococcus granulosus tyrosine protein kinase Fyn 0.0065 0.0123 0.0123
Echinococcus granulosus c src tyrosine kinase 0.0032 0.0031 0.0031
Echinococcus granulosus twitchin 0.0025 0.0009 0.0009
Echinococcus granulosus protein tyrosine kinase 0.0293 0.076 0.076
Entamoeba histolytica protein kinase, putative 0.0071 0.0139 0.2168
Schistosoma mansoni protein kinase 0.0149 0.0358 0.4703
Entamoeba histolytica hypothetical protein 0.0141 0.0336 0.5234
Brugia malayi intracellular kinase 0.0062 0.0113 0.1465
Schistosoma mansoni serine/threonine protein kinase 0.0152 0.0365 0.4802
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0138 0.0325 0.4221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0201 0.302
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0059 0.0107 1
Echinococcus granulosus casein kinase I alpha 0.005 0.0081 0.0081
Schistosoma mansoni tyrosine kinase 0.0032 0.0031 0.0405
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0062 0.0113 0.0286
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0075 0.2849
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0196 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0048 0.0075 0.0976
Schistosoma mansoni adapter molecule crk 0.0022 0.0003 0.0035
Brugia malayi bone morphogenetic protein type 1 receptor 0.009 0.0193 0.2508
Schistosoma mansoni serine/threonine protein kinase 0.0267 0.0687 0.9033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0089 0.0089
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.0163
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0141 0.0336 0.436
Echinococcus multilocularis transfer RNA-Thr 0.0196 0.0488 0.0488
Echinococcus multilocularis tyrosine protein kinase Abl 0.0032 0.0031 0.0031
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.0328 0.4259
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0149 0.0358 0.097
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.1172
Brugia malayi Stress-activated protein kinase jnk-1 0.0267 0.0687 0.8922
Schistosoma mansoni tyrosine kinase 0.0065 0.0123 0.1612
Echinococcus granulosus tyrosine protein kinase Src64B 0.0065 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0075 0.1029
Plasmodium falciparum glycogen synthase kinase 3 0.0062 0.0113 0.5575
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0048 0.0075 0.0988
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0138 0.0325 0.4221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.009 0.0193 0.2508
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0376
Schistosoma mansoni protein kinase 0.0026 0.0012 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0075 0.1029
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0251 0.0641 1
Entamoeba histolytica protein kinase rad3, putative 0.0141 0.0336 0.5234
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0138 0.0325 0.0325
Brugia malayi Cam kinase protein 1 0.0025 0.001 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Loa Loa (eye worm) hypothetical protein 0.0072 0.014 0.1823
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0132
Trypanosoma brucei aurora B kinase 0.0071 0.0139 0.2042
Leishmania major hypothetical protein, conserved 0.1306 0.3594 1
Trypanosoma brucei casein kinase I, isoform 2 0.005 0.0081 0.1129
Echinococcus granulosus MAM 0.0032 0.0029 0.0029
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0071 0.0139 0.2168
Loa Loa (eye worm) hypothetical protein 0.0077 0.0156 0.2021
Echinococcus multilocularis casein kinase I delta 0.005 0.0081 0.0081
Schistosoma mansoni tyrosine kinase 0.0065 0.0123 0.1612
Brugia malayi MH2 domain containing protein 0.0139 0.0328 0.4259
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0065 0.0123 0.0123
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.1029
Loa Loa (eye worm) hypothetical protein 0.0082 0.0168 0.2188
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0071 0.0139 0.7006
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0048 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0068 0.0132 0.1713
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0091 0.0194 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0182 0.0448 0.0448
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0048 0.0075 0.0075
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0075 0.0075
Echinococcus multilocularis casein kinase I alpha 0.005 0.0081 0.0081
Trichomonas vaginalis STE family protein kinase 0.0026 0.0012 0.003
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0036 0.0042 0.0042
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0065 0.0123 0.0123
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0048 0.0075 0.0075
Schistosoma mansoni growth factor receptor-bound protein 0.0022 0.0003 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0071 0.0139 0.0139
Echinococcus granulosus Vam6:Vps39 protein 0.0028 0.0019 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.022 0.0555 0.7302
Loa Loa (eye worm) hypothetical protein 0.0095 0.0207 0.2693
Schistosoma mansoni protein kinase 0.0104 0.023 0.3025
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0048 0.0075 0.0075
Echinococcus granulosus fibroblast growth factor receptor 4 0.0121 0.0279 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Brugia malayi Protein kinase domain containing protein 0.0187 0.0463 0.6016
Schistosoma mansoni protein kinase 0.0071 0.0139 0.1829
Schistosoma mansoni hypothetical protein 0.0032 0.0029 0.038
Loa Loa (eye worm) hypothetical protein 0.0109 0.0246 0.3195
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0141 0.0336 0.092
Echinococcus granulosus casein kinase I delta 0.005 0.0081 0.0081
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0022 0.0003 0.0034
Schistosoma mansoni nck2/grb4 0.0022 0.0003 0.0035
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0251 0.0641 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0149 0.0358 0.0358
Echinococcus granulosus activin receptor type 0.0428 0.1138 0.1138
Brugia malayi Protein kinase domain containing protein 0.0036 0.0042 0.0545
Echinococcus multilocularis casein kinase I delta 0.005 0.0081 0.0081
Schistosoma mansoni protein kinase 0.0026 0.0012 0.0159
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0075 0.0976
Echinococcus multilocularis 0.0068 0.0129 0.0129
Schistosoma mansoni protein kinase 0.0026 0.0012 0.0159
Entamoeba histolytica casein kinase, putative 0.005 0.0081 0.127
Loa Loa (eye worm) hypothetical protein 0.0196 0.0488 0.6339
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0113 0.1758
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0066 0.0864
Onchocerca volvulus 0.0062 0.0113 0.2435
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0034
Loa Loa (eye worm) SRC-1 0.0065 0.0123 0.1592
Entamoeba histolytica protein kinase, putative 0.003 0.0023 0.0356
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0251 0.0641 0.0641
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0081 0.1071
Echinococcus multilocularis aurora kinase A 0.0071 0.0139 0.0139
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0251 0.0641 0.1761
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0089 0.0089
Echinococcus granulosus tyrosine protein kinase Src42A 0.0046 0.0069 0.0069
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0091 0.0194 1
Trypanosoma cruzi aurora B kinase, putative 0.0071 0.0139 0.0348
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0187 0.0463 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0025 0.001 0.0132
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0048 0.0075 0.0163
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.3531
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0075 0.0976
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0022 0.0003 0.0034
Echinococcus multilocularis casein kinase i 0.005 0.0081 0.0081
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0075 0.0976
Echinococcus multilocularis mitogen activated protein kinase 14 0.0149 0.0358 0.0358
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0025 0.001 0.001
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0059 0.0107 0.4744
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0026 0.0012 0.0012
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0075 0.0151 0.1962
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0102 0.1326
Entamoeba histolytica p21-activated kinase 0.003 0.0023 0.0356
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0076 0.0152 0.2244
Echinococcus granulosus serine:threonine protein kinase TAO1 0.022 0.0555 0.0555
Brugia malayi hypothetical protein 0.0032 0.0029 0.0376
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0251 0.0641 0.1761
Echinococcus granulosus tyrosine protein kinase Fyn 0.0065 0.0123 0.0123
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0028 0.0019 0.0019
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0048 0.0075 0.0163
Schistosoma mansoni tyrosine kinase 0.0121 0.0279 0.3664
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0082 0.0168 0.0168
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0003 0.0003
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0075 0.0181
Trypanosoma cruzi casein kinase, putative 0.005 0.0081 0.0181
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0023 0.0005 0.0065
Schistosoma mansoni vav2 0.0024 0.0006 0.0084
Echinococcus multilocularis activated cdc42 kinase 1 0.0196 0.0488 0.0488
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0048 0.0075 0.1029
Schistosoma mansoni protein kinase 0.0075 0.0151 0.1986
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0048 0.0075 0.1029
Echinococcus multilocularis protein KINase family member (kin 25) 0.0082 0.0168 0.0168
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0204 0.2681
Schistosoma mansoni protein kinase 0.0149 0.0358 0.4703
Schistosoma mansoni tyrosine kinase 0.0172 0.0422 0.5555
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0075 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0641 0.8331
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0187 0.0463 0.0463
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0251 0.0641 0.8435
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0194 0.2914
Entamoeba histolytica hypothetical protein 0.0048 0.0075 0.1172
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0157 0.0381 0.5872
Toxoplasma gondii aurora kinase 0.0071 0.0139 0.2042
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0141 0.0336 0.5234
Trichomonas vaginalis CK1 family protein kinase 0.005 0.0081 0.1129
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0196 0.0488 0.0488

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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