Detailed information for compound 433724

Basic information

Technical information
  • TDR Targets ID: 433724
  • Name: ditert-butyl 2-(4-phenoxyphenyl)iminoimidazol idine-1,3-dicarboxylate
  • MW: 453.531 | Formula: C25H31N3O5
  • H donors: 0 H acceptors: 2 LogP: 5.21 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(C1=Nc1ccc(cc1)Oc1ccccc1)C(=O)OC(C)(C)C)OC(C)(C)C
  • InChi: 1S/C25H31N3O5/c1-24(2,3)32-22(29)27-16-17-28(23(30)33-25(4,5)6)21(27)26-18-12-14-20(15-13-18)31-19-10-8-7-9-11-19/h7-15H,16-17H2,1-6H3
  • InChiKey: NXHNQOWDIBTSCH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(4-phenoxyphenyl)iminoimidazolidine-1,3-dicarboxylic acid ditert-butyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0048 0.0075 0.0075
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0182 0.0448 0.0448
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0091 0.0194 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0075 0.0075
Echinococcus multilocularis casein kinase I alpha 0.005 0.0081 0.0081
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0036 0.0042 0.0042
Trichomonas vaginalis STE family protein kinase 0.0026 0.0012 0.003
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0065 0.0123 0.0123
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0048 0.0075 0.0075
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0071 0.0139 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Schistosoma mansoni growth factor receptor-bound protein 0.0022 0.0003 0.0035
Echinococcus granulosus Vam6:Vps39 protein 0.0028 0.0019 0.0019
Schistosoma mansoni protein kinase 0.0104 0.023 0.3025
Loa Loa (eye worm) hypothetical protein 0.0095 0.0207 0.2693
Schistosoma mansoni serine/threonine protein kinase 0.022 0.0555 0.7302
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0048 0.0075 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0121 0.0279 0.0279
Schistosoma mansoni protein kinase 0.0071 0.0139 0.1829
Brugia malayi Protein kinase domain containing protein 0.0187 0.0463 0.6016
Schistosoma mansoni hypothetical protein 0.0032 0.0029 0.038
Entamoeba histolytica protein kinase rad3, putative 0.0141 0.0336 0.5234
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0251 0.0641 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0075 0.1029
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0138 0.0325 0.0325
Brugia malayi Cam kinase protein 1 0.0025 0.001 0.0132
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0132
Loa Loa (eye worm) hypothetical protein 0.0072 0.014 0.1823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Leishmania major hypothetical protein, conserved 0.1306 0.3594 1
Trypanosoma brucei aurora B kinase 0.0071 0.0139 0.2042
Trypanosoma brucei casein kinase I, isoform 2 0.005 0.0081 0.1129
Echinococcus granulosus MAM 0.0032 0.0029 0.0029
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0071 0.0139 0.2168
Loa Loa (eye worm) hypothetical protein 0.0077 0.0156 0.2021
Echinococcus multilocularis casein kinase I delta 0.005 0.0081 0.0081
Schistosoma mansoni tyrosine kinase 0.0065 0.0123 0.1612
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.1029
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0065 0.0123 0.0123
Brugia malayi MH2 domain containing protein 0.0139 0.0328 0.4259
Loa Loa (eye worm) hypothetical protein 0.0082 0.0168 0.2188
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0048 0.0075 0.0075
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0071 0.0139 0.7006
Loa Loa (eye worm) hypothetical protein 0.0068 0.0132 0.1713
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0089 0.0089
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.0163
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0141 0.0336 0.436
Echinococcus multilocularis tyrosine protein kinase Abl 0.0032 0.0031 0.0031
Echinococcus multilocularis transfer RNA-Thr 0.0196 0.0488 0.0488
Schistosoma mansoni tyrosine kinase 0.0065 0.0123 0.1612
Brugia malayi Stress-activated protein kinase jnk-1 0.0267 0.0687 0.8922
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.0328 0.4259
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0149 0.0358 0.097
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.1172
Echinococcus granulosus tyrosine protein kinase Src64B 0.0065 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0075 0.1029
Plasmodium falciparum glycogen synthase kinase 3 0.0062 0.0113 0.5575
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0048 0.0075 0.0988
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0138 0.0325 0.4221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.009 0.0193 0.2508
Schistosoma mansoni protein kinase 0.0026 0.0012 0.0159
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0376
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0048 0.0075 0.0163
Echinococcus granulosus tyrosine protein kinase Fyn 0.0065 0.0123 0.0123
Echinococcus granulosus c src tyrosine kinase 0.0032 0.0031 0.0031
Echinococcus granulosus protein tyrosine kinase 0.0293 0.076 0.076
Echinococcus granulosus twitchin 0.0025 0.0009 0.0009
Entamoeba histolytica protein kinase, putative 0.0071 0.0139 0.2168
Brugia malayi intracellular kinase 0.0062 0.0113 0.1465
Schistosoma mansoni serine/threonine protein kinase 0.0152 0.0365 0.4802
Schistosoma mansoni protein kinase 0.0149 0.0358 0.4703
Entamoeba histolytica hypothetical protein 0.0141 0.0336 0.5234
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0138 0.0325 0.4221
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0059 0.0107 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0201 0.302
Echinococcus granulosus casein kinase I alpha 0.005 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0048 0.0075 0.0976
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0196 0.0488 0.0488
Schistosoma mansoni tyrosine kinase 0.0032 0.0031 0.0405
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0075 0.2849
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0062 0.0113 0.0286
Schistosoma mansoni adapter molecule crk 0.0022 0.0003 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0267 0.0687 0.9033
Brugia malayi bone morphogenetic protein type 1 receptor 0.009 0.0193 0.2508
Echinococcus multilocularis protein KINase family member (kin 25) 0.0082 0.0168 0.0168
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0204 0.2681
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0048 0.0075 0.1029
Schistosoma mansoni protein kinase 0.0075 0.0151 0.1986
Schistosoma mansoni tyrosine kinase 0.0172 0.0422 0.5555
Schistosoma mansoni protein kinase 0.0149 0.0358 0.4703
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0075 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0641 0.8331
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0187 0.0463 0.0463
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0194 0.2914
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0251 0.0641 0.8435
Entamoeba histolytica hypothetical protein 0.0048 0.0075 0.1172
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0157 0.0381 0.5872
Toxoplasma gondii aurora kinase 0.0071 0.0139 0.2042
Trichomonas vaginalis CK1 family protein kinase 0.005 0.0081 0.1129
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0141 0.0336 0.5234
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0196 0.0488 0.0488
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0026 0.0012 0.0012
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0075 0.0151 0.1962
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0102 0.1326
Entamoeba histolytica p21-activated kinase 0.003 0.0023 0.0356
Echinococcus granulosus serine:threonine protein kinase TAO1 0.022 0.0555 0.0555
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0076 0.0152 0.2244
Brugia malayi hypothetical protein 0.0032 0.0029 0.0376
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0251 0.0641 0.1761
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0028 0.0019 0.0019
Echinococcus granulosus tyrosine protein kinase Fyn 0.0065 0.0123 0.0123
Schistosoma mansoni tyrosine kinase 0.0121 0.0279 0.3664
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0048 0.0075 0.0163
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0003 0.0003
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0082 0.0168 0.0168
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0075 0.0181
Trypanosoma cruzi casein kinase, putative 0.005 0.0081 0.0181
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0023 0.0005 0.0065
Echinococcus multilocularis activated cdc42 kinase 1 0.0196 0.0488 0.0488
Schistosoma mansoni vav2 0.0024 0.0006 0.0084
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0048 0.0075 0.1029
Loa Loa (eye worm) SRC-1 0.0065 0.0123 0.1592
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0081 0.1071
Entamoeba histolytica protein kinase, putative 0.003 0.0023 0.0356
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0251 0.0641 0.0641
Echinococcus granulosus tyrosine protein kinase Src42A 0.0046 0.0069 0.0069
Echinococcus multilocularis aurora kinase A 0.0071 0.0139 0.0139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0089 0.0089
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0251 0.0641 0.1761
Trypanosoma cruzi aurora B kinase, putative 0.0071 0.0139 0.0348
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0091 0.0194 1
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0187 0.0463 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0025 0.001 0.0132
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0048 0.0075 0.0163
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.3531
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0075 0.0976
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0022 0.0003 0.0034
Echinococcus multilocularis casein kinase i 0.005 0.0081 0.0081
Echinococcus multilocularis mitogen activated protein kinase 14 0.0149 0.0358 0.0358
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0025 0.001 0.001
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0075 0.0976
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0059 0.0107 0.4744
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0141 0.0336 0.092
Loa Loa (eye worm) hypothetical protein 0.0109 0.0246 0.3195
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0022 0.0003 0.0034
Echinococcus granulosus casein kinase I delta 0.005 0.0081 0.0081
Schistosoma mansoni nck2/grb4 0.0022 0.0003 0.0035
Echinococcus multilocularis mitogen activated protein kinase 11 0.0149 0.0358 0.0358
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0251 0.0641 1
Echinococcus granulosus activin receptor type 0.0428 0.1138 0.1138
Brugia malayi Protein kinase domain containing protein 0.0036 0.0042 0.0545
Echinococcus multilocularis casein kinase I delta 0.005 0.0081 0.0081
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0075 0.0976
Schistosoma mansoni protein kinase 0.0026 0.0012 0.0159
Echinococcus multilocularis 0.0068 0.0129 0.0129
Schistosoma mansoni protein kinase 0.0026 0.0012 0.0159
Entamoeba histolytica casein kinase, putative 0.005 0.0081 0.127
Loa Loa (eye worm) hypothetical protein 0.0196 0.0488 0.6339
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0113 0.1758
Onchocerca volvulus 0.0062 0.0113 0.2435
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0066 0.0864
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0034
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0077 0.0155 0.2008
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0028 0.0019 0.0019
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0149 0.0358 0.5508
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0091 0.0194 0.0194
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0152 0.0365 0.4743
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.022 0.0555 0.7213
Loa Loa (eye worm) gastrulation defective protein 1 0.0147 0.035 0.4555
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0065 0.0123 0.0123
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0113 0.1625
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0005 0.0065
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0196 0.0488 0.6341
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0065 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.0246 0.3735
Brugia malayi hypothetical protein 0.0028 0.0019 0.025
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0048 0.0075 0.3531
Brugia malayi Immunoglobulin I-set domain containing protein 0.0124 0.0288 0.3741
Brugia malayi hypothetical protein 0.0068 0.0132 0.1713
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0075 0.0976
Schistosoma mansoni rap gtpase-activating protein 0.0028 0.0019 0.0253
Trichomonas vaginalis STE family protein kinase 0.0026 0.0012 0.003
Entamoeba histolytica protein kinase, putative 0.0062 0.0113 0.1758
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0092 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.0488 0.6419
Echinococcus granulosus casein kinase I alpha 0.005 0.0081 0.0081
Brugia malayi Protein kinase domain containing protein 0.0155 0.0373 0.485
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0048 0.0075 0.0988
Trypanosoma cruzi casein kinase, putative 0.005 0.0081 0.0181
Echinococcus multilocularis NCK adaptor protein 0.0024 0.0008 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0152 0.1997
Loa Loa (eye worm) TK protein kinase 0.0043 0.006 0.0782
Onchocerca volvulus 0.0068 0.0132 0.2847
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0025 0.001 0.001
Entamoeba histolytica protein kinase, putative 0.003 0.0023 0.0356
Loa Loa (eye worm) hypothetical protein 0.0141 0.0336 0.436
Echinococcus multilocularis tyrosine protein kinase HCK 0.0043 0.006 0.006
Leishmania major phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.0181
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0075 0.0075
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0042 0.0059 0.0115
Onchocerca volvulus 0.0032 0.0029 0.0624
Echinococcus granulosus tyrosine protein kinase HCK 0.0043 0.006 0.006
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0121 0.0279 0.0279
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0076 0.0152 0.2244
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0201 0.302
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0641 0.8331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0075 0.0075
Echinococcus multilocularis PAK box P21 Rho binding 0.0026 0.0012 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0089 0.0089
Leishmania major phosphatidylinositol kinase related protein, putative 0.0048 0.0075 0.0181
Onchocerca volvulus Huntingtin homolog 0.0142 0.0338 0.7299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.0163
Loa Loa (eye worm) hypothetical protein 0.0091 0.0194 0.2522
Plasmodium vivax serine/threonine kinase-1, putative 0.0076 0.0152 0.7699
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0076 0.0152 0.1972
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0204 0.2681
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.1029
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0065 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0075 0.1029
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0028 0.0019 0.0143
Schistosoma mansoni protein kinase C mu 0.0085 0.0178 0.2345
Echinococcus granulosus casein kinase i 0.005 0.0081 0.0081
Leishmania major casein kinase, putative 0.005 0.0081 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0121 0.0279 0.0279
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0075 0.3531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0157 0.0381 0.5872
Echinococcus granulosus activated cdc42 kinase 1 0.0196 0.0488 0.0488
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.1172
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0048 0.0635
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0251 0.0641 0.1808
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0139 0.1806
Echinococcus granulosus hypothetical protein 0.0068 0.0129 0.0129
Schistosoma mansoni tyrosine kinase 0.0293 0.076 1
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0003 0.0034
Brugia malayi Temporarily assigned gene name protein 59 0.0028 0.0019 0.025
Plasmodium vivax hypothetical protein 0.0048 0.0075 0.3531
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0075 0.0976
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0194 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0251 0.0641 0.0641
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0251 0.0641 0.8435
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0093 0.0201 0.0528
Echinococcus granulosus activated cdc42 kinase 1 0.0196 0.0488 0.0488
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.022 0.0555 0.0555
Echinococcus granulosus TGF-beta receptor type-1 0.0088 0.0188 0.0188
Brugia malayi hypothetical protein 0.0142 0.0338 0.4391
Schistosoma mansoni protein kinase 0.0036 0.0042 0.0552
Brugia malayi cyclin-dependent kinase 7 homolog 0.0094 0.0204 0.2648
Echinococcus multilocularis 0.0075 0.0151 0.0151
Brugia malayi probable protein kinase 0.0104 0.023 0.2988
Brugia malayi Tyrosine-protein kinase abl-1 0.0032 0.0031 0.04
Entamoeba histolytica protein kinase , putative 0.0071 0.0139 0.2168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Entamoeba histolytica hypothetical protein 0.0048 0.0075 0.1172
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0003 0.0042
Trypanosoma brucei protein kinase, putative 0.0062 0.0113 0.1625
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0141 0.0336 0.5157
Echinococcus multilocularis casein kinase I alpha 0.005 0.0081 0.0081
Echinococcus granulosus protein kinase 0.0075 0.0151 0.0151
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0149 0.0358 0.0358
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.001 0.0134
Echinococcus granulosus casein kinase I alpha 0.005 0.0081 0.0081
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.3531
Echinococcus granulosus mitogen activated protein kinase 14 0.0149 0.0358 0.0358
Echinococcus granulosus protein kinase shaggy 0.0062 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0028 0.0019 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0048 0.0075 0.1029
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0091 0.0194 0.0194
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0251 0.0641 0.1808
Echinococcus granulosus NCK adaptor protein 0.0022 0.0003 0.0003
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0028 0.0953
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0028 0.0953
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0048 0.0075 0.3531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0026 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0152 0.0365 0.4743
Loa Loa (eye worm) hypothetical protein 0.0142 0.0338 0.4391
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0048 0.0075 0.1029
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0048 0.0075 0.1002
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0048 0.0075 0.0988
Leishmania major protein kinase, putative 0.0071 0.0139 0.0359
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.1172
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0251 0.0641 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0251 0.0641 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.025
Brugia malayi serine/threonine kinase 12 0.0071 0.0139 0.1806
Brugia malayi Protein kinase domain containing protein 0.0076 0.0152 0.1972
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0075 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0089 0.1153
Plasmodium falciparum casein kinase 1 0.005 0.0081 0.3873
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0028 0.0019 0.0253
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0062 0.0113 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.1258 0.3459 1
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0026 0.0012 0.0012
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0048 0.0075 0.0976
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0071 0.0139 0.2168
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0076 0.0152 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0141 0.0336 0.0336
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0149 0.0358 0.0984
Loa Loa (eye worm) hypothetical protein 0.0142 0.0338 0.4391
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.0113 0.1465
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0251 0.0641 0.1761
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0141 0.0336 0.0336
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0032 0.0031 0.0405
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0641 0.8331
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0095 0.0207 0.0207
Brugia malayi Serine/threonine-protein kinase SULU 0.022 0.0555 0.7213
Echinococcus granulosus tyrosine protein kinase Lyn 0.0073 0.0145 0.0145
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0113 0.1758
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0025 0.001 0.0132
Echinococcus granulosus cyclin dependent kinase 7 0.0094 0.0204 0.0204
Entamoeba histolytica protein kinase, putative 0.0025 0.001 0.0159
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0194 0.5
Trypanosoma cruzi casein kinase, delta isoform, putative 0.005 0.0081 0.0181
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0139 0.2042
Onchocerca volvulus 0.0032 0.0029 0.0624
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0048 0.0075 0.0075
Entamoeba histolytica protein kinase, putative 0.0025 0.001 0.0159
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0048 0.0075 0.0976
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0065 0.0123 0.0123
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0194 0.5
Entamoeba histolytica hypothetical protein 0.0048 0.0075 0.1172
Trypanosoma cruzi casein kinase, putative 0.005 0.0081 0.0181
Loa Loa (eye worm) hypothetical protein 0.0068 0.0132 0.1712
Loa Loa (eye worm) hypothetical protein 0.0058 0.0102 0.1326
Giardia lamblia Kinase, CMGC GSK 0.0062 0.0113 0.16
Echinococcus granulosus casein kinase I delta 0.005 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.004 0.0051 0.0669
Toxoplasma gondii FATC domain-containing protein 0.0141 0.0336 0.5157
Echinococcus granulosus aurora kinase A 0.0071 0.0139 0.0139
Brugia malayi Protein kinase domain containing protein 0.0297 0.077 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0048 0.0075 0.0075
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0076 0.0152 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0048 0.0075 0.0988
Echinococcus multilocularis Zinc finger, PHD finger 0.0048 0.0075 0.0075
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0149 0.0358 0.4648
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0149 0.0358 0.0984
Loa Loa (eye worm) TK/ALK protein kinase 0.0275 0.0708 0.9204
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0251 0.0641 1
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0028 0.0019 0.0253
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0463 0.609
Brugia malayi casein kinase I 0.005 0.0081 0.1058
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0048 0.0075 0.0163
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0026 0.0012 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0089 0.1167
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.0113 0.1465
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0376
Echinococcus granulosus tyrosine protein kinase Fyn 0.0065 0.0123 0.0123
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0251 0.0641 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0661
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0251 0.0641 0.0641
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0251 0.0641 0.1761
Brugia malayi P38 map kinase family protein 2 0.0149 0.0358 0.4648
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0075 0.1029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0075 0.0976
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0025 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0075 0.1029
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0187 0.0463 0.6016
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0062 0.0113 0.1483
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0075 0.0976
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.005 0.0081 0.1058
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0077 0.0154 0.2008
Brugia malayi SRC-1 0.0065 0.0123 0.1592
Trypanosoma cruzi casein kinase, putative 0.005 0.0081 0.0181
Giardia lamblia Hypothetical protein 0.0048 0.0075 0.1002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0075 0.1029
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0065 0.0123 0.0123
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0194 0.5
Echinococcus granulosus tyrosine protein kinase Blk 0.0054 0.0092 0.0092
Echinococcus multilocularis protein kinase shaggy 0.0062 0.0113 0.0113
Brugia malayi Protein kinase domain containing protein 0.0275 0.0709 0.9207
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0048 0.0075 0.1029
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0048 0.0075 0.0988
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0048 0.0075 0.0988
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0075 0.1029
Leishmania major protein kinase, putative 0.0076 0.0152 0.0395
Echinococcus granulosus growth factor receptor bound protein 2 0.0024 0.0008 0.0008
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0048 0.0075 0.0075
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0251 0.0641 0.1808
Entamoeba histolytica hypothetical protein 0.0048 0.0075 0.1172
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0076 0.0152 0.2244
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0076 0.0152 0.0385
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0376
Schistosoma mansoni hypothetical protein 0.0109 0.0246 0.3235
Trichomonas vaginalis CMGC family protein kinase 0.0076 0.0152 0.2244
Onchocerca volvulus 0.0048 0.0075 0.1623
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0048 0.0075 0.0988
Loa Loa (eye worm) TK protein kinase 0.0124 0.0288 0.3741
Echinococcus granulosus c-Jun N-terminal kinases 0.0267 0.0687 0.0687
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0194 0.5
Brugia malayi Protein kinase domain containing protein 0.0077 0.0155 0.2008
Loa Loa (eye worm) hypothetical protein 0.0068 0.0129 0.1677
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0062 0.0113 0.0272
Loa Loa (eye worm) hypothetical protein 0.0186 0.046 0.5973
Brugia malayi serine/threonine-protein kinase PAK 7 0.0213 0.0537 0.6977
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0085 0.0178 0.2317
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.0373 0.491
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0251 0.0641 1
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0088 0.0188 0.0188
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0138 0.0325 0.4221
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0036 0.0042 0.0042
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0051 0.0661
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0048 0.0075 0.1029
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0149 0.0358 0.0358
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0089 0.1153
Giardia lamblia Kinase, CMGC GSK 0.0062 0.0113 0.16
Brugia malayi Protein kinase domain containing protein 0.0196 0.0488 0.6339
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0251 0.0641 0.0641
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0089 0.0089
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0075 0.0163
Echinococcus multilocularis growth factor receptor bound protein 2 0.0022 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Trichomonas vaginalis CK1 family protein kinase 0.005 0.0081 0.1129
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0065 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0075 0.1029
Echinococcus granulosus serine protein kinase ATM 0.0141 0.0336 0.0336
Schistosoma mansoni protein kinase 0.0149 0.0358 0.4703
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0091 0.0194 0.5
Loa Loa (eye worm) hypothetical protein 0.0072 0.014 0.1823
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0077 0.0155 0.2008
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0076 0.0152 0.0385
Leishmania major hypothetical protein, unknown function 0.0048 0.0075 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Entamoeba histolytica protein kinase, putative 0.0043 0.006 0.0938
Brugia malayi C1-like domain containing protein 0.0085 0.0178 0.2317
Giardia lamblia Kinase, CK1 Casein kinase 0.005 0.0081 0.1102
Brugia malayi hypothetical protein 0.022 0.0555 0.7213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Schistosoma mansoni tyrosine kinase 0.0028 0.0017 0.023
Loa Loa (eye worm) hypothetical protein 0.0233 0.0592 0.7687
Echinococcus multilocularis death associated protein kinase 1 0.092 0.2514 0.2514
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0054 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.025
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0139 0.1806
Echinococcus multilocularis casein kinase I alpha 0.005 0.0081 0.0081
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0124 0.0288 0.3737
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0071 0.0139 0.0139
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0075 0.1029
Schistosoma mansoni protein kinase 0.009 0.0193 0.2539
Brugia malayi serine/threonine protein kinase 6 0.0071 0.0139 0.1806
Echinococcus multilocularis cyclin dependent kinase 19 0.0155 0.0373 0.0373
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0026 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0187 0.0463 0.0463
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0048 0.0075 0.1172
Echinococcus granulosus dual specificity protein kinase clk2 0.0076 0.0152 0.0152
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0139 0.2042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0139 0.1829
Trypanosoma cruzi casein kinase, putative 0.005 0.0081 0.0181
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0065 0.0123 0.0123
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0139 0.2042
Echinococcus multilocularis tyrosine protein kinase Blk 0.0054 0.0092 0.0092
Echinococcus multilocularis serine protein kinase ATM 0.0141 0.0336 0.0336
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0025 0.001 0.0132
Echinococcus multilocularis TGF beta receptor type 1 0.0088 0.0188 0.0188
Echinococcus granulosus peptidase Clp S14 family 0.0059 0.0107 0.0107
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0267 0.0687 0.0687
Giardia lamblia Phosphatidylinositol 4-kinase 0.0048 0.0075 0.1002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.1172
Entamoeba histolytica casein kinase 1, putative 0.005 0.0081 0.127
Echinococcus multilocularis mitogen activated protein kinase 11 0.0149 0.0358 0.0358
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.1029
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0065 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Loa Loa (eye worm) hypothetical protein 0.0157 0.0381 0.4947
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0141 0.0336 0.4414
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0048 0.0075 0.1002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0187 0.0463 0.6016
Leishmania major phosphatidylinositol 3-kinase, putative 0.0251 0.0641 0.1761
Loa Loa (eye worm) hypothetical protein 0.0093 0.0201 0.2608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0089 0.1167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Onchocerca volvulus 0.005 0.0081 0.1759
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0048 0.0075 0.3531
Onchocerca volvulus 0.0048 0.0075 0.1623
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0187 0.0463 0.6016
Onchocerca volvulus 0.0028 0.0019 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0213 0.0537 0.6977
Echinococcus granulosus tyrosine protein kinase Src42A 0.0065 0.0123 0.0123
Toxoplasma gondii hypothetical protein 0.0031 0.0028 0.0278
Brugia malayi FAT domain containing protein 0.0109 0.0246 0.3195
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0251 0.0641 1
Brugia malayi protein C17H12.11 0.0068 0.0132 0.1713
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0194 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0251 0.0641 0.1808
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0003 0.0034
Schistosoma mansoni protein kinase 0.005 0.0081 0.1071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Schistosoma mansoni growth factor receptor-bound protein 0.0024 0.0008 0.0101
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0085 0.0178 0.2317
Echinococcus granulosus tyrosine kinase 0.0054 0.0092 0.0092
Echinococcus multilocularis c src tyrosine kinase 0.0032 0.0031 0.0031
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0048 0.0075 0.1029
Brugia malayi Protein kinase domain 0.0026 0.0012 0.0157
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0141 0.0336 0.436
Giardia lamblia Kinase, CMGC CLK 0.0076 0.0152 0.2221
Entamoeba histolytica protein kinase, putative 0.0026 0.0012 0.0188
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0075 0.1029
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0025 0.001 0.001
Plasmodium vivax glycogen synthase kinase 3, putative 0.0062 0.0113 0.5575
Plasmodium falciparum serine/threonine protein kinase, putative 0.0071 0.0139 0.7006
Entamoeba histolytica protein kinase, putative 0.0026 0.0012 0.0188
Schistosoma mansoni protein kinase 0.0088 0.0188 0.2468
Giardia lamblia Aurora kinase 0.0071 0.0139 0.2018
Leishmania major phosphatidylinositol kinase, putative 0.0048 0.0075 0.0181
Giardia lamblia GTOR 0.0251 0.0641 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0048 0.0075 0.1029
Schistosoma mansoni tyrosine kinase 0.0032 0.0031 0.0405
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0048 0.0075 0.0163
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0071 0.0139 0.2168
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0048 0.0075 0.1172
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0109 0.0246 0.0246
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0062 0.0113 0.0113
Schistosoma mansoni tyrosine kinase 0.0082 0.0168 0.2215
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.0381 0.5872
Loa Loa (eye worm) phosphatidylinositol kinase 0.0048 0.0075 0.0976
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0182 0.0448 0.0448
Brugia malayi protein-tyrosine kinase 0.0054 0.0092 0.1192
Echinococcus multilocularis protein tyrosine kinase 0.0293 0.076 0.076
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.0328 0.4259
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0075 0.0976
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0109 0.0246 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0003 0.0042
Echinococcus multilocularis tyrosine protein kinase Srms 0.0054 0.0092 0.0092
Echinococcus granulosus TGF beta receptor type 1 0.0088 0.0188 0.0188
Echinococcus multilocularis peptidase Clp (S14 family) 0.0059 0.0107 0.0107
Echinococcus multilocularis MAM 0.0032 0.0029 0.0029
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0113 0.1625
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0046 0.0069 0.0069
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0075 0.0976
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0048 0.0075 0.1029
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0075 0.1029
Echinococcus multilocularis cyclin dependent kinase 7 0.0094 0.0204 0.0204
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0036 0.0042 0.0545
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0089 0.1167
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0059 0.0107 1
Toxoplasma gondii casein kinase I 0.005 0.0081 0.1129
Brugia malayi Protein kinase domain containing protein 0.0196 0.0488 0.6341
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0025 0.001 0.001
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0121 0.0279 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0124 0.0288 0.3737
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0036 0.0042 0.0042
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0157 0.0381 0.5872
Schistosoma mansoni hypothetical protein 0.0032 0.0029 0.038
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.025
Loa Loa (eye worm) hypothetical protein 0.0068 0.0132 0.1712
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0048 0.0075 0.0075
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.1172
Schistosoma mansoni peptidase Clp (S14 family) 0.0091 0.0194 0.2553
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0062 0.0113 0.1625
Plasmodium falciparum protein serine/threonine kinase-1 0.0076 0.0152 0.7699
Brugia malayi Probable ClpP-like protease 0.0091 0.0194 0.2522
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3597 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0071 0.0139 0.2168
Loa Loa (eye worm) hypothetical protein 0.0081 0.0166 0.2161
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0075 0.1172
Loa Loa (eye worm) hypothetical protein 0.0048 0.0075 0.0976
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0139 0.1806
Loa Loa (eye worm) TK protein kinase 0.0054 0.0092 0.1192
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0155 0.0373 0.485
Brugia malayi Sex muscle abnormal protein 5 0.0022 0.0003 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0066 0.0864
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0267 0.0687 0.8922
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0102 0.1326
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0075 0.1029
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0075 0.0163
Trichomonas vaginalis STE family protein kinase 0.0026 0.0012 0.003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0641 0.8331
Schistosoma mansoni fkbp-rapamycin associated protein 0.0141 0.0336 0.4414
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0045 0.0066 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0139 0.2042
Brugia malayi casein kinase 1, delta 0.005 0.0081 0.1058
Onchocerca volvulus 0.0081 0.0166 0.3592
Leishmania major protein kinase, putative 0.0076 0.0152 0.0395
Schistosoma mansoni vam6/vps39 related 0.0028 0.0019 0.0253
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0094 0.0204 0.2648
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0022 0.0003 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0336 0.5157
Plasmodium vivax casein kinase 1, putative 0.005 0.0081 0.3873
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0065 0.0123 0.0123
Leishmania major phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.0181
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0048 0.0075 0.3531
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0026 0.0012 0.0012
Trichomonas vaginalis STE family protein kinase 0.0026 0.0012 0.003
Entamoeba histolytica protein kinase, putative 0.0071 0.0139 0.2168
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0036 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0141 0.0336 0.092
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0194 0.2914
Onchocerca volvulus 0.0077 0.0156 0.336
Loa Loa (eye worm) TK/FAK protein kinase 0.0297 0.077 1
Schistosoma mansoni hypothetical protein 0.0048 0.0075 0.0988
Echinococcus multilocularis mitogen activated protein kinase 14 0.0149 0.0358 0.0358
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0075 0.1029
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0152 0.1997
Trichomonas vaginalis CK1 family protein kinase 0.005 0.0081 0.1129
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.005 0.0081 0.1058
Trichomonas vaginalis STE family protein kinase 0.0026 0.0012 0.003
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0025 0.001 0.001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0102 0.1326
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0075 0.0075
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0048 0.0075 0.3531
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0003 0.0042
Echinococcus granulosus cyclin dependent kinase 19 0.0155 0.0373 0.0373
Echinococcus multilocularis dual specificity protein kinase clk2 0.0076 0.0152 0.0152
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.005 0.0081 0.1058
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0048 0.0075 0.1029
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0251 0.0641 0.1808
Onchocerca volvulus Huntingtin homolog 0.0142 0.0338 0.7299
Echinococcus multilocularis activin receptor type 0.0428 0.1138 0.1138
Echinococcus multilocularis 0.0048 0.0075 0.0075
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0138 0.0325 0.0325
Onchocerca volvulus 0.0042 0.0059 0.1268
Echinococcus granulosus mitogen activated protein kinase 11 0.0149 0.0358 0.0358
Brugia malayi serine/threonine-protein kinase 6 0.0071 0.0139 0.1806
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0045 0.0066 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0641 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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