Detailed information for compound 435164

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 571.448 | Formula: C28H26Cl2F2N6O
  • H donors: 1 H acceptors: 3 LogP: 4.99 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1ccc(c(c1)F)C(Cn1ncnc1)(CN1CCN(CC1)c1ccc(cc1)/N=C/c1ccc(cc1Cl)Cl)O
  • InChi: 1S/C28H26Cl2F2N6O/c29-21-2-1-20(26(30)13-21)15-34-23-4-6-24(7-5-23)37-11-9-36(10-12-37)16-28(39,17-38-19-33-18-35-38)25-8-3-22(31)14-27(25)32/h1-8,13-15,18-19,39H,9-12,16-17H2/b34-15+
  • InChiKey: YCSUJXOLAKOFER-PUHLOBNQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0021 0.0317 1
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0181 0.0393
Loa Loa (eye worm) CYP4Cod1 0.0055 0.11 0.3837
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0181 0.0827
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.015 0.3303 1
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.015 0.3303 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0054 0.0054
Trypanosoma cruzi mitochondrial protein 99, putative 0.0015 0.0181 0.0827
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.002 0.0281 0.0321
Loa Loa (eye worm) hypothetical protein 0.0034 0.0615 0.2074
Echinococcus granulosus Aminotransferase class III 0.0021 0.0317 0.0317
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0181 0.0181
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0015 0.0181 0.0497
Loa Loa (eye worm) hypothetical protein 0.0015 0.0181 0.0497
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.002 0.0281 0.0321
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.001 0.0053 0.0053
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0076 0.1596 0.4353
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.1596 0.4748
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0015 0.0181 0.0181
Schistosoma mansoni cytochrome P450 0.002 0.0281 0.0281
Schistosoma mansoni hypothetical protein 0.0034 0.0615 0.0615
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0015 0.0181 0.0181
Onchocerca volvulus Putative neutral sphingomyelinase 0.0015 0.0181 0.2636
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0181 0.0827
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0181 0.0507
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0015 0.0181 0.0827
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.002 0.0281 0.0321
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0054 0.0054
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0054 0.0054
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0054 0.002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.1596 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0054 0.0054
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0317 0.0317
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0054 0.0054
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0076 0.1596 0.1596
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0015 0.0181 0.0827
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.001 0.0053 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0054 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0054 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0054 0.0054
Brugia malayi CCR4 0.0015 0.0181 0.0507
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0015 0.0181 0.0393
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.002 0.0281 0.0321
Toxoplasma gondii cytochrome p450 superfamily protein 0.002 0.0281 0.0707
Loa Loa (eye worm) cytochrome P450 0.002 0.0281 0.0861
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.002 0.0281 0.0321
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0181 0.0393
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0037
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0021 0.0317 0.0438
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0054 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0054 0.0037
Brugia malayi hypoxia-induced factor 1 0.0118 0.2566 0.9164
Leishmania major hypothetical protein, conserved 0.0015 0.0181 0.0827
Echinococcus granulosus FTZ F1 alpha 0.001 0.0054 0.0054
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0054 0.0048
Schistosoma mansoni hypothetical protein 0.0034 0.0615 0.0615
Mycobacterium leprae putative cytochrome p450 0.002 0.0281 0.0701
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0021 0.0317 0.0121
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0054 0.0054
Schistosoma mansoni nocturnin 0.0015 0.0181 0.0181
Schistosoma mansoni hypothetical protein 0.0074 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0037
Schistosoma mansoni thyroid hormone receptor 0.001 0.0054 0.0054
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0015 0.0181 0.0181
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.1596 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0054 0.002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0615 0.0615
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0054 0.0048
Schistosoma mansoni hypothetical protein 0.0438 1 1
Echinococcus multilocularis cpg binding protein 0.0033 0.0578 0.0578
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0054 0.0048
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0181 0.0507
Leishmania major cytochrome p450-like protein 0.002 0.0281 0.1476
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0054 0.0054
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0181 0.0827
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0076 0.1596 1
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0181 0.0827
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0281 0.1476
Schistosoma mansoni aryl hydrocarbon receptor 0.0038 0.0709 0.0709
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.2008 0.7137
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.002 0.0281 0.0321
Leishmania major cytochrome p450-like protein 0.002 0.0281 0.1476
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0015 0.0181 0.0827
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0076 0.1596 0.4534
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0044 0.0044
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0181 0.0507
Trypanosoma cruzi cytochrome P450, putative 0.0055 0.11 0.6785
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0054 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.002 0.0281 0.0321
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.11 0.3837
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0021 0.0317 0.1003
Leishmania major hypothetical protein, conserved 0.0015 0.0181 0.0827
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0021 0.0317 0.0317
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0181 0.0507
Onchocerca volvulus 0.0015 0.0181 0.2636
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.002 0.0281 0.0321
Brugia malayi Cytochrome P450 family protein 0.002 0.0281 0.087
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0054 0.0048
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0037
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0054 0.0054
Leishmania major RNA-editing complex protein MP100, putative 0.0015 0.0181 0.0827
Brugia malayi Cytochrome P450 family protein 0.002 0.0281 0.087
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0615 0.2082
Loa Loa (eye worm) hypothetical protein 0.0015 0.0181 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0054 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0054 0.0048
Brugia malayi exodeoxyribonuclease III family protein 0.0076 0.1596 0.5643
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0054 0.0048
Trypanosoma brucei cytochrome P450, putative 0.0055 0.11 0.6495
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0054 0.0054
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.002 0.0281 0.0321
Onchocerca volvulus 0.0031 0.0537 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0076 0.1596 1
Schistosoma mansoni hypothetical protein 0.002 0.0281 0.0281
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.1338 0.1338
Plasmodium vivax ornithine aminotransferase, putative 0.0021 0.0317 0.0966
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0181 0.0497
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.002 0.0281 0.0321
Leishmania major endonuclease/exonuclease protein-like protein 0.0015 0.0181 0.0827
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0054 0.0054
Echinococcus granulosus aryl hydrocarbon receptor 0.001 0.0053 0.0053
Onchocerca volvulus 0.001 0.0054 0.002
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.002 0.0281 0.0321
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.002 0.0281 0.0321
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0021 0.0317 0.0813
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0054 0.0054
Schistosoma mansoni thyroid hormone receptor 0.001 0.0054 0.0054
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.001 0.0053 0.0034
Echinococcus granulosus single minded 2 0.0028 0.0479 0.0479
Brugia malayi cytochrome P450 0.002 0.0281 0.087
Echinococcus multilocularis transfer RNA-Lys 0.0028 0.0479 0.0479
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.0317 0.0121
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.002 0.0281 0.0321
Schistosoma mansoni synaptojanin 0.0015 0.0181 0.0181
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0181 0.0497
Echinococcus granulosus cpg binding protein 0.0033 0.0578 0.0578
Brugia malayi nuclear hormone receptor 0.001 0.0054 0.0048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0076 0.1596 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0054 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0054 0.0048
Loa Loa (eye worm) hypothetical protein 0.0108 0.2326 0.8289
Echinococcus multilocularis GPCR, family 2 0.0034 0.0615 0.0615
Schistosoma mansoni ap endonuclease 0.0076 0.1596 0.1596
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0054 0.0054
Echinococcus granulosus traf and tnf receptor associated protein 0.0015 0.0181 0.0181
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.1534 0.5417
Schistosoma mansoni coup transcription factor 0.001 0.0054 0.0054
Leishmania major cytochrome p450-like protein 0.0055 0.11 0.6785
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0054 0.0054
Leishmania major lanosterol 14-alpha-demethylase, putative 0.002 0.0281 0.1476
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0054 0.0037
Mycobacterium leprae Conserved hypothetical protein 0.002 0.0281 0.0701
Loa Loa (eye worm) hypothetical protein 0.0035 0.0642 0.2173
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0054 0.0054
Mycobacterium ulcerans hypothetical protein 0.015 0.3303 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0054 0.0054
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0181 0.0393
Echinococcus multilocularis Aminotransferase class III 0.0021 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0015 0.0181 0.0497
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0281 0.0861
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.2326 0.8291
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0021 0.0317 0.0438
Brugia malayi bHLH-PAS transcription factor 0.0028 0.0479 0.1589
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.002 0.0281 0.0321
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0181 0.0827
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0054 0.0037
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0021 0.0317 0.0813
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0054 0.0037
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0615 0.0615
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0615 0.2074
Onchocerca volvulus 0.0028 0.0479 0.8793
Brugia malayi CXXC zinc finger family protein 0.0031 0.0537 0.1801
Echinococcus multilocularis dnaJ subfamily B 0.0438 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2008 0.2008
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0054 0.0054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.2326 0.8289
Toxoplasma gondii exonuclease III APE 0.0076 0.1596 1
Schistosoma mansoni hypothetical protein 0.0034 0.0615 0.0615
Brugia malayi Cytochrome P450 family protein 0.0055 0.11 0.3843
Schistosoma mansoni cpg binding protein 0.0031 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0015 0.0181 0.0497
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.002 0.0281 0.0321
Schistosoma mansoni cript-related 0.0015 0.0181 0.0181
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0076 0.1596 0.5638
Mycobacterium tuberculosis Probable aminotransferase 0.015 0.3303 1
Schistosoma mansoni hypothetical protein 0.0015 0.0181 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0054 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0054 0.0037
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0054 0.0054
Schistosoma mansoni ap endonuclease 0.0076 0.1596 0.1596
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0037
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0015 0.0181 0.0827
Echinococcus granulosus ornithine aminotransferase 0.0021 0.0317 0.0317
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0181 0.0507
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.2008 0.2008
Treponema pallidum exodeoxyribonuclease (exoA) 0.0076 0.1596 1
Brugia malayi hypothetical protein 0.0128 0.2797 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0054 0.0054
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0054 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0054 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.2008 0.2008
Mycobacterium ulcerans acetylornithine aminotransferase 0.0021 0.0317 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0054 0.0037
Echinococcus multilocularis deoxyribonuclease 1 2 0.0015 0.0181 0.0181
Schistosoma mansoni cpg binding protein 0.0033 0.0578 0.0578
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0015 0.0181 0.0393
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0015 0.0181 0.0393
Brugia malayi Cytochrome P450 family protein 0.0055 0.11 0.3843
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.11 0.3837
Plasmodium falciparum ornithine aminotransferase 0.0021 0.0317 0.0966
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0076 0.1596 1
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0054 0.002
Brugia malayi ecdysteroid receptor 0.001 0.0054 0.0048
Brugia malayi steroid hormone receptor 0.001 0.0054 0.0048
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0537 0.1792
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0037
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0015 0.0181 0.0827
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0076 0.1596 1
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.1596 0.4748
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0181 0.0497
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0281 0.1476
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0181 0.0507
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0054 0.0054
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0054 0.0048
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.015 0.3303 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1534 0.5413
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0181 0.0827
Schistosoma mansoni carbon catabolite repressor protein 0.0015 0.0181 0.0181
Brugia malayi PAS domain containing protein 0.0038 0.0709 0.2425
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0615 0.0615
Leishmania major pantothenate kinase subunit, putative 0.0015 0.0181 0.0827
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1176 0.7035
Echinococcus multilocularis 0.002 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0037
Schistosoma mansoni cpg binding protein 0.0033 0.0578 0.0578
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.2008 0.2008
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0181 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0054 0.0048
Echinococcus granulosus neutral sphingomyelinase 0.0015 0.0181 0.0181
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0015 0.0181 0.0181
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0015 0.0181 0.0393
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0076 0.1596 0.1596
Echinococcus multilocularis neutral sphingomyelinase 0.0015 0.0181 0.0181
Trypanosoma cruzi cytochrome P450, putative 0.0055 0.11 0.6785
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0181 0.0497
Trypanosoma cruzi mitochondrial protein 99, putative 0.0015 0.0181 0.0827
Trichomonas vaginalis Phospholipase C precursor, putative 0.0015 0.0181 0.0393
Echinococcus multilocularis synaptojanin 1 0.0015 0.0181 0.0181
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0015 0.0181 0.0827
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0015 0.0181 0.0827
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0615 0.2082
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0054 0.0054
Mycobacterium ulcerans putative regulatory protein 0.0028 0.0479 0.0655
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.002 0.0281 0.0321
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0037
Echinococcus granulosus GPCR family 2 0.0034 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0128 0.2797 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0055 0.11 0.2711
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.2326 0.8291
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0054 0.0054
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.015 0.3303 1
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0181 0.0181
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.002 0.0281 0.0321
Trypanosoma cruzi cytochrome p450-like protein, putative 0.002 0.0281 0.1476
Schistosoma mansoni hypothetical protein 0.0034 0.0615 0.0615
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0076 0.1596 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0054 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.2008 0.2008
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.002 0.0281 0.0707
Echinococcus multilocularis traf and tnf receptor associated protein 0.0015 0.0181 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0054 0.0048
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.0317 0.0121
Onchocerca volvulus 0.0015 0.0181 0.2636
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0054 0.0048
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0181 0.0827
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0021 0.0317 0.0438
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0015 0.0181 0.0393
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.002 0.0281 0.0321
Mycobacterium ulcerans L-lysine aminotransferase 0.0021 0.0317 0.0121
Loa Loa (eye worm) hypothetical protein 0.001 0.0053 0.0034
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0021 0.0317 0.0121
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.002 0.0281 0.0321
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0021 0.0317 0.0813
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0181 0.0507
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0181 0.0497
Leishmania major hypothetical protein, conserved 0.0015 0.0181 0.0827
Loa Loa (eye worm) hypoxia-induced factor 1 0.0118 0.2566 0.9163
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0021 0.0317 0.0438
Echinococcus granulosus synaptojanin 1 0.0015 0.0181 0.0181
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0615 0.0615
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0021 0.0317 0.0966
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2008 0.2008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0054 0.0048
Brugia malayi nuclear receptor NHR-88 0.001 0.0054 0.0048
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0076 0.1596 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.2008 0.7134
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0015 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0037
Schistosoma mansoni synaptojanin 0.0015 0.0181 0.0181
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0317 0.0317
Schistosoma mansoni single-minded 0.0038 0.0709 0.0709
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0181 0.0507
Echinococcus granulosus cytochrome P450 2K1 0.002 0.0281 0.0281
Echinococcus multilocularis aryl hydrocarbon receptor 0.001 0.0053 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2008 0.2008
Schistosoma mansoni neutral sphingomyelinase 0.0015 0.0181 0.0181
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0044 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.002 0.0281 0.0321

Activities

Activity type Activity value Assay description Source Reference
MIC80 (functional) = 8 ug ml-1 Antifungal activity against Candida parapsilosis ATCC22019 by microbroth dilution method ChEMBL. 17184885
MIC80 (functional) = 8 ug ml-1 Antifungal activity against Candida krusei ATCC6258 by microbroth dilution method ChEMBL. 17184885
MIC80 (functional) = 8 ug ml-1 Antifungal activity against Torulopsis glabrata by microbroth dilution method ChEMBL. 17184885
MIC80 (functional) > 64 ug ml-1 Antifungal activity against Candida albicans after 24 hrs by microbroth dilution method ChEMBL. 17184885
MIC80 (functional) = 64 ug ml-1 Antifungal activity against Cryptococcus neoformans after 72 hrs by microbroth dilution method ChEMBL. 17184885
MIC80 (functional) > 64 ug ml-1 Antifungal activity against Candida tropicalis by microbroth dilution method ChEMBL. 17184885
MIC80 (functional) > 64 ug ml-1 Antifungal activity against Candida albicans after 24 hrs by microbroth dilution method ChEMBL. 17184885
MIC80 (functional) = 64 ug ml-1 Antifungal activity against Cryptococcus neoformans after 72 hrs by microbroth dilution method ChEMBL. 17184885

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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