Detailed information for compound 437987

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 741.733 | Formula: C34H47NO17
  • H donors: 10 H acceptors: 10 LogP: -2.92 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@@H]([C@H]1O[C@@H]([C@H]([C@@H]1O)O)O[C@@H]1[C@@H](CO[C@@H]2O[C@H](CO)[C@@H]([C@@H]([C@H]2O)O)O)O[C@@H]([C@@H]([C@H]1O)NC(=O)COCc1ccccc1)OCc1ccccc1)O
  • InChi: 1S/C34H47NO17/c36-11-19(38)30-27(43)29(45)34(51-30)52-31-21(15-48-33-28(44)26(42)24(40)20(12-37)49-33)50-32(47-14-18-9-5-2-6-10-18)23(25(31)41)35-22(39)16-46-13-17-7-3-1-4-8-17/h1-10,19-21,23-34,36-38,40-45H,11-16H2,(H,35,39)/t19-,20+,21+,23+,24-,25+,26-,27-,28+,29-,30+,31+,32-,33+,34+/m0/s1
  • InChiKey: BSCZOINIWQKASP-KTHPHPIHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0072 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1976 0.6372
Trypanosoma brucei prolyl endopeptidase 0.0428 0.5045 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0308 0.0927
Toxoplasma gondii hypothetical protein 0.0045 0.04 0.0459
Schistosoma mansoni bromodomain containing protein 0.0065 0.0647 0.075
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3087 1
Brugia malayi Bromodomain containing protein 0.0077 0.079 0.1536
Echinococcus granulosus prolyl endopeptidase 0.0428 0.5045 0.5845
Brugia malayi Calcitonin receptor-like protein seb-1 0.0203 0.2309 0.4557
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0632 0.1222
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.2059 0.2386
Entamoeba histolytica prolyl oligopeptidase family protein 0.0045 0.04 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0353 0.0666
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0308 0.0927
Echinococcus multilocularis zinc finger protein 0.0021 0.0115 0.0115
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0308 0.0578
Echinococcus granulosus GPCR family 2 0.0064 0.0632 0.0732
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.04 0.1227
Entamoeba histolytica prolyl oligopeptidase family protein 0.0045 0.04 1
Toxoplasma gondii aldehyde dehydrogenase 0.0185 0.2099 0.3948
Schistosoma mansoni hypothetical protein 0.0064 0.0632 0.0732
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0518 0.06
Loa Loa (eye worm) prolyl oligopeptidase 0.0045 0.04 0.0761
Brugia malayi MH2 domain containing protein 0.0024 0.0149 0.026
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0064 0.0074
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0438 0.0438
Brugia malayi prolyl oligopeptidase family protein 0.0428 0.5045 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0324 0.0608
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0604 0.0604
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.2099 0.2431
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0045 0.04 0.0459
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0045 0.04 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.0428 0.5045 1
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0438 0.0507
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0308 0.0565
Loa Loa (eye worm) hypothetical protein 0.0064 0.0632 0.1222
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0308 0.0927
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0308 0.0927
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.209 0.6745
Brugia malayi hypothetical protein 0.0026 0.0177 0.0316
Brugia malayi PHD-finger family protein 0.0027 0.018 0.0322
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.1894 0.3732
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0045 0.04 0.0749
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0045 0.04 0.1227
Schistosoma mansoni zinc finger protein 0.0015 0.0043 0.0049
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0632 0.0632
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0632 0.1222
Schistosoma mansoni smad 0.0024 0.0149 0.0173
Plasmodium falciparum peptidase, putative 0.0045 0.04 1
Brugia malayi prolyl oligopeptidase family protein 0.0045 0.04 0.0761
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0308 0.0565
Leishmania major oligopeptidase b 0.017 0.192 0.3775
Echinococcus multilocularis GPCR, family 2 0.0064 0.0632 0.0632
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0108 0.0178
Trypanosoma brucei prolyl oligopeptidase, putative 0.017 0.192 0.3775
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0177 0.0303
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0438 0.0507
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0049
Echinococcus multilocularis acylamino acid releasing enzyme 0.0045 0.04 0.04
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0045 0.04 0.0749
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0045 0.04 0.0464
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3087 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0308 0.0927
Schistosoma mansoni hypothetical protein 0.0064 0.0632 0.0732
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.2059 0.2386
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0604 0.0699
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.017 0.192 0.5
Plasmodium vivax hypothetical protein, conserved 0.0045 0.04 1
Echinococcus granulosus zinc finger protein 0.0021 0.0115 0.0133
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.2059 0.4061
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0518 0.0518
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0438 0.0507
Schistosoma mansoni Smad4 0.0024 0.0149 0.0173
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0308 0.0927
Loa Loa (eye worm) hypothetical protein 0.0045 0.04 0.0761
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0518 0.0518
Echinococcus granulosus Smad4 0.0024 0.0149 0.0173
Echinococcus multilocularis geminin 0.0171 0.1926 0.1926
Loa Loa (eye worm) Smad1 0.0024 0.0149 0.026
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.017 0.192 0.3775
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0308 0.0927
Trypanosoma brucei oligopeptidase b 0.017 0.192 0.3775
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.2099 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1894 0.1894
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.06 0.0696
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0151 0.0151
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.055 0.0766
Schistosoma mansoni hypothetical protein 0.0292 0.339 0.3927
Leishmania major hypothetical protein, conserved 0.0015 0.0043 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0316
Schistosoma mansoni microtubule-associated protein tau 0.0725 0.8632 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0396 0.0752
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0072 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.209 0.6745
Echinococcus granulosus geminin 0.0171 0.1926 0.2231
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3087 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0149 0.0149
Echinococcus granulosus cpg binding protein 0.0033 0.025 0.029
Schistosoma mansoni hypothetical protein 0.0171 0.1926 0.2231
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0045 0.04 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.04 0.0761
Loa Loa (eye worm) hypothetical protein 0.0048 0.0438 0.0834
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0438 0.0834
Brugia malayi Bromodomain containing protein 0.0039 0.0323 0.0606
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0308 0.0927
Schistosoma mansoni cpg binding protein 0.0029 0.0207 0.024
Brugia malayi hypothetical protein 0.0119 0.1299 0.2548
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0308 0.0308
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.3087 0.6104
Giardia lamblia Alanyl dipeptidyl peptidase 0.0045 0.04 0.5
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0045 0.04 0.0749
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.2059 0.2059
Onchocerca volvulus 0.0029 0.0207 0.0363
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0384 0.4501 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0428 0.5045 0.5845
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0149 0.0173
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0308 0.0927
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0438 0.0822
Onchocerca volvulus 0.0048 0.0438 0.0822
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.2059 0.4061
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.4153 0.8225
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0072 0.0083
Loa Loa (eye worm) hypothetical protein 0.0138 0.1533 0.3013
Schistosoma mansoni alpha-glucosidase 0.0145 0.161 0.1866
Echinococcus granulosus Dipeptidyl peptidase 9 0.0045 0.04 0.0464
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1976 0.6372
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1976 0.6372
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0632 0.0632
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0308 0.0357
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0177 0.0303
Loa Loa (eye worm) hypothetical protein 0.0055 0.0518 0.0994
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0518 0.06
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0045 0.04 0.04
Echinococcus multilocularis cpg binding protein 0.0033 0.025 0.025
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0045 0.04 0.0464
Onchocerca volvulus Huntingtin homolog 0.0119 0.1299 0.2539
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.1533 0.3013
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0149 0.0173
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.1894 0.3732
Brugia malayi mbt repeat family protein 0.0048 0.0438 0.0834
Schistosoma mansoni cpg binding protein 0.0033 0.025 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.04 0.0749
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.017 0.192 0.3775
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0045 0.04 0.0464
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0149 0.0173
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0064 0.0064
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0294 0.0341
Giardia lamblia Alanyl dipeptidyl peptidase 0.0045 0.04 0.5
Trypanosoma cruzi oligopeptidase b 0.017 0.192 0.3775
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.3087 0.6104
Schistosoma mansoni alpha-glucosidase 0.0145 0.161 0.1866
Brugia malayi CXXC zinc finger family protein 0.0029 0.0207 0.0376
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.2059 0.2386
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0045 0.04 0.0749
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0045 0.04 0.1227
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0518 0.06
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0632 0.0732
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0308 0.7552
Onchocerca volvulus 0.0097 0.1035 0.2012
Echinococcus multilocularis Smad4 0.0024 0.0149 0.0149
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.1894 0.2194
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0149 0.026
Trypanosoma cruzi oligopeptidase b 0.017 0.192 0.3775
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.2059 0.2059
Schistosoma mansoni hypothetical protein 0.0064 0.0632 0.0732
Entamoeba histolytica prolyl oligopeptidase family protein 0.0045 0.04 1
Trypanosoma brucei ISWI complex protein 0.0015 0.0043 0.0036
Echinococcus granulosus smad 0.0024 0.0149 0.0173
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0203 0.2309 0.4557
Schistosoma mansoni smad1 5 8 and 0.0024 0.0149 0.0173
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0045 0.04 0.0749
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.2059 0.2386
Echinococcus multilocularis smad 0.0024 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0428 0.5045 1
Schistosoma mansoni cpg binding protein 0.0033 0.025 0.029
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0308 0.7552
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.4853 0.4853
Loa Loa (eye worm) prolyl oligopeptidase 0.0045 0.04 0.0761
Onchocerca volvulus Huntingtin homolog 0.0119 0.1299 0.2539
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0632 0.1222
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1894 0.1894
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0185 0.2099 0.2099
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0064 0.0074
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0045 0.04 0.04
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0308 0.0565
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0072 0.0083
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0438 0.0438
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.017 0.192 0.3775
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.2099 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.1299 0.2548
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0308 0.0578
Echinococcus granulosus dnaJ subfamily B 0.0413 0.4853 0.5622
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0438 0.0507
Brugia malayi prolyl oligopeptidase family protein 0.0045 0.04 0.0761
Brugia malayi hypothetical protein 0.0017 0.0063 0.009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0203 0.2309 0.4557
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0632 0.0732
Schistosoma mansoni hypothetical protein 0.0021 0.0108 0.0125
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0149 0.026
Schistosoma mansoni alpha glucosidase 0.0037 0.0308 0.0357
Loa Loa (eye worm) hypothetical protein 0.0071 0.0718 0.1392
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3087 1
Echinococcus granulosus acylamino acid releasing enzyme 0.0045 0.04 0.0464
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0149 0.0149
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.04 0.0749
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0207 0.0376
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.2099 1
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.4153 0.8225
Schistosoma mansoni hypothetical protein 0.0171 0.1926 0.2231
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0185 0.2099 0.2431
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1976 0.6372
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0177 0.0303
Brugia malayi prolyl oligopeptidase family protein 0.0045 0.04 0.0761
Brugia malayi MH2 domain containing protein 0.0355 0.4153 0.8225
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0025 0.0013
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0045 0.04 0.0459
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0185 0.2099 0.4131
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1976 0.6372
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.2059 0.2386
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1976 0.6372
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1976 0.6372
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0518 0.0994
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0045 0.04 0.0749
Brugia malayi MH1 domain containing protein 0.0024 0.0149 0.026
Echinococcus multilocularis prolyl endopeptidase 0.0428 0.5045 0.5045
Brugia malayi MH2 domain containing protein 0.0024 0.0149 0.026
Leishmania major hypothetical protein, conserved 0.0026 0.0177 0.0303
Brugia malayi mbt repeat family protein 0.0048 0.0438 0.0834
Loa Loa (eye worm) MBCTL1 0.0055 0.0518 0.0994
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0045 0.04 0.0464
Trypanosoma cruzi ISWI complex protein 0.0015 0.0043 0.0036
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0151 0.0175
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0072 0.0106
Trypanosoma brucei glucosidase, putative 0.0037 0.0308 0.0565
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0308 0.0271
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0151 0.0175
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0045 0.04 0.0464
Brugia malayi MH1 domain containing protein 0.0024 0.0149 0.026
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3087 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0064 0.0074
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.017 0.192 0.3775
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0107
Brugia malayi prolyl oligopeptidase family protein 0.0045 0.04 0.0761
Loa Loa (eye worm) hypothetical protein 0.0119 0.1299 0.2548
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.2099 0.2431
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.2147 0.2487
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3087 1
Echinococcus granulosus microtubule associated protein 2 0.0725 0.8632 1
Loa Loa (eye worm) hypothetical protein 0.0203 0.2309 0.4557
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0045 0.04 0.0749
Schistosoma mansoni smad1 5 8 and 0.0024 0.0149 0.0173
Schistosoma mansoni hypothetical protein 0.0138 0.1533 0.1776
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.2147 0.2147
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0428 0.5045 0.5845
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0185 0.2099 0.0693
Entamoeba histolytica hypothetical protein, conserved 0.0045 0.04 1
Schistosoma mansoni hypothetical protein 0.0413 0.4853 0.5622
Schistosoma mansoni hypothetical protein 0.0064 0.0632 0.0732
Trypanosoma cruzi prolyl endopeptidase 0.0428 0.5045 1
Schistosoma mansoni smad1 5 8 and 0.0024 0.0149 0.0173
Brugia malayi Smad1 0.0024 0.0149 0.026
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0438 0.0507
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0294 0.0294
Toxoplasma gondii prolyl endopeptidase 0.0428 0.5045 1
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.1976 0.3887
Trypanosoma cruzi ISWI complex protein 0.0015 0.0043 0.0036
Echinococcus multilocularis microtubule associated protein 2 0.0725 0.8632 0.8632
Schistosoma mansoni zinc finger protein 0.0021 0.0115 0.0133
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0428 0.5045 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.86 mM Inhibition of Trypanosoma cruzi trans-sialidase after 15 mins ChEMBL. 17292612

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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