Detailed information for compound 437996

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1066.01 | Formula: C46H67NO27
  • H donors: 16 H acceptors: 16 LogP: -6.11 Rotable bonds: 23
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]([C@@H]1O[C@H]([C@@H]([C@H]1O)O)O[C@H]1[C@H](CO[C@@H]2O[C@H](CO)[C@@H]([C@@H]([C@H]2O[C@@H]2O[C@H](CO)[C@@H]([C@@H]([C@H]2O)O)O)O[C@H]2O[C@@H](CO)[C@H]([C@H]([C@@H]2O)O)O)O)O[C@H]([C@@H]([C@@H]1O)NC(=O)COCc1ccccc1)OCc1ccccc1)O
  • InChi: 1S/C46H67NO27/c48-11-21(52)38-34(60)37(63)45(71-38)72-39-25(70-42(65-16-20-9-5-2-6-10-20)27(31(39)57)47-26(53)18-64-15-19-7-3-1-4-8-19)17-66-46-41(74-44-36(62)33(59)29(55)23(13-50)68-44)40(30(56)24(14-51)69-46)73-43-35(61)32(58)28(54)22(12-49)67-43/h1-10,21-25,27-46,48-52,54-63H,11-18H2,(H,47,53)/t21-,22+,23-,24-,25+,27-,28-,29+,30+,31+,32-,33+,34-,35+,36-,37-,38+,39+,40+,41-,42-,43-,44+,45+,46-/m1/s1
  • InChiKey: KLAOTLNKFULRHN-MHIUJGEDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0308 0.0357
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0308 0.7552
Trypanosoma brucei ISWI complex protein 0.0015 0.0043 0.0036
Loa Loa (eye worm) hypothetical protein 0.0041 0.0353 0.0666
Giardia lamblia Alanyl dipeptidyl peptidase 0.0045 0.04 0.5
Loa Loa (eye worm) MBCTL1 0.0055 0.0518 0.0994
Brugia malayi prolyl oligopeptidase family protein 0.0045 0.04 0.0761
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0045 0.04 0.0464
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.06 0.0696
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.017 0.192 0.3775
Echinococcus multilocularis smad 0.0024 0.0149 0.0149
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0438 0.0438
Entamoeba histolytica prolyl oligopeptidase family protein 0.0045 0.04 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.0428 0.5045 1
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0045 0.04 1
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0045 0.04 0.1227
Brugia malayi hypothetical protein 0.0017 0.0063 0.009
Onchocerca volvulus 0.0029 0.0207 0.0363
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3087 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.2099 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0632 0.1222
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.2059 0.2059
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.1533 0.3013
Brugia malayi prolyl oligopeptidase family protein 0.0428 0.5045 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.3087 0.6104
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0151 0.0175
Schistosoma mansoni zinc finger protein 0.0015 0.0043 0.0049
Brugia malayi mbt repeat family protein 0.0048 0.0438 0.0834
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0308 0.0927
Schistosoma mansoni hypothetical protein 0.0171 0.1926 0.2231
Schistosoma mansoni alpha-glucosidase 0.0145 0.161 0.1866
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0045 0.04 0.04
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0045 0.04 0.0749
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0108 0.0178
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0203 0.2309 0.4557
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0632 0.0632
Loa Loa (eye worm) hypothetical protein 0.0045 0.04 0.0761
Toxoplasma gondii prolyl endopeptidase 0.0428 0.5045 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0308 0.0927
Schistosoma mansoni zinc finger protein 0.0021 0.0115 0.0133
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.209 0.6745
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0438 0.0507
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.2099 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0632 0.1222
Trypanosoma cruzi oligopeptidase b 0.017 0.192 0.3775
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0308 0.0927
Schistosoma mansoni hypothetical protein 0.0064 0.0632 0.0732
Schistosoma mansoni hypothetical protein 0.0021 0.0108 0.0125
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0308 0.7552
Trypanosoma cruzi ISWI complex protein 0.0015 0.0043 0.0036
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0308 0.0927
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0072 0.0072
Echinococcus granulosus Smad4 0.0024 0.0149 0.0173
Brugia malayi Calcitonin receptor-like protein seb-1 0.0203 0.2309 0.4557
Brugia malayi MH2 domain containing protein 0.0024 0.0149 0.026
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.3087 0.6104
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0518 0.06
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0308 0.0927
Loa Loa (eye worm) hypothetical protein 0.0045 0.04 0.0761
Loa Loa (eye worm) hypothetical protein 0.0071 0.0718 0.1392
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0308 0.0927
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0438 0.0438
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0308 0.0308
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0308 0.0927
Echinococcus multilocularis zinc finger protein 0.0021 0.0115 0.0115
Echinococcus multilocularis acylamino acid releasing enzyme 0.0045 0.04 0.04
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0177 0.0303
Loa Loa (eye worm) hypothetical protein 0.0055 0.0518 0.0994
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0384 0.4501 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0308 0.0578
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.2059 0.2386
Plasmodium vivax hypothetical protein, conserved 0.0045 0.04 1
Schistosoma mansoni smad1 5 8 and 0.0024 0.0149 0.0173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.2059 0.2386
Loa Loa (eye worm) hypothetical protein 0.0203 0.2309 0.4557
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.017 0.192 0.3775
Loa Loa (eye worm) hypothetical protein 0.0138 0.1533 0.3013
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0064 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3087 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0294 0.0341
Schistosoma mansoni Smad4 0.0024 0.0149 0.0173
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0045 0.04 0.0749
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0308 0.0565
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0207 0.0376
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0518 0.0518
Echinococcus granulosus dnaJ subfamily B 0.0413 0.4853 0.5622
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0632 0.0732
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.4153 0.8225
Toxoplasma gondii aldehyde dehydrogenase 0.0185 0.2099 0.3948
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0185 0.2099 0.0693
Onchocerca volvulus 0.0097 0.1035 0.2012
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3087 1
Brugia malayi Bromodomain containing protein 0.0039 0.0323 0.0606
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.055 0.0766
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0428 0.5045 0.5845
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0438 0.0822
Echinococcus granulosus microtubule associated protein 2 0.0725 0.8632 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0072 0.0083
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0518 0.0518
Schistosoma mansoni hypothetical protein 0.0138 0.1533 0.1776
Loa Loa (eye worm) prolyl oligopeptidase 0.0045 0.04 0.0761
Loa Loa (eye worm) hypothetical protein 0.0039 0.0324 0.0608
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1976 0.6372
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0308 0.0565
Onchocerca volvulus Huntingtin homolog 0.0119 0.1299 0.2539
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0013
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0185 0.2099 0.4131
Leishmania major hypothetical protein, conserved 0.0015 0.0043 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.2099 1
Plasmodium falciparum peptidase, putative 0.0045 0.04 1
Brugia malayi prolyl oligopeptidase family protein 0.0045 0.04 0.0761
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0045 0.04 0.0464
Schistosoma mansoni alpha-glucosidase 0.0145 0.161 0.1866
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0072 0.0083
Echinococcus granulosus GPCR family 2 0.0064 0.0632 0.0732
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.4153 0.8225
Brugia malayi CXXC zinc finger family protein 0.0029 0.0207 0.0376
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.1894 0.3732
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0045 0.04 0.0464
Trypanosoma brucei prolyl endopeptidase 0.0428 0.5045 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.1299 0.2548
Toxoplasma gondii hypothetical protein 0.0045 0.04 0.0459
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0072 0.0106
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.2059 0.4061
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.017 0.192 0.3775
Echinococcus granulosus cpg binding protein 0.0033 0.025 0.029
Schistosoma mansoni hypothetical protein 0.0064 0.0632 0.0732
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0438 0.0834
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0149 0.026
Echinococcus multilocularis geminin 0.0171 0.1926 0.1926
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0151 0.0175
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0149 0.026
Echinococcus granulosus acylamino acid releasing enzyme 0.0045 0.04 0.0464
Schistosoma mansoni hypothetical protein 0.0064 0.0632 0.0732
Schistosoma mansoni cpg binding protein 0.0033 0.025 0.029
Schistosoma mansoni hypothetical protein 0.0413 0.4853 0.5622
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0045 0.04 0.04
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0438 0.0507
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.1976 0.3887
Loa Loa (eye worm) hypothetical protein 0.0045 0.0396 0.0752
Echinococcus granulosus zinc finger protein 0.0021 0.0115 0.0133
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0604 0.0604
Schistosoma mansoni cpg binding protein 0.0033 0.025 0.029
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0632 0.0732
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1894 0.1894
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1976 0.6372
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0064 0.0074
Loa Loa (eye worm) Smad1 0.0024 0.0149 0.026
Brugia malayi hypothetical protein 0.0119 0.1299 0.2548
Echinococcus granulosus Dipeptidyl peptidase 9 0.0045 0.04 0.0464
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.209 0.6745
Trypanosoma cruzi prolyl endopeptidase 0.0428 0.5045 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0025 0.0013
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.2147 0.2487
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.2147 0.2147
Loa Loa (eye worm) hypothetical protein 0.0428 0.5045 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0149 0.0149
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0045 0.04 0.0749
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1976 0.6372
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0438 0.0507
Loa Loa (eye worm) prolyl oligopeptidase 0.0045 0.04 0.0761
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0149 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.04 0.0749
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1976 0.6372
Schistosoma mansoni hypothetical protein 0.0292 0.339 0.3927
Schistosoma mansoni smad 0.0024 0.0149 0.0173
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0518 0.06
Entamoeba histolytica prolyl oligopeptidase family protein 0.0045 0.04 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0428 0.5045 0.5845
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0149 0.0149
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0308 0.0565
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0045 0.04 0.0459
Echinococcus granulosus smad 0.0024 0.0149 0.0173
Brugia malayi MH2 domain containing protein 0.0024 0.0149 0.026
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1976 0.6372
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0045 0.04 0.0749
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0438 0.0507
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0428 0.5045 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0632 0.1222
Entamoeba histolytica hypothetical protein, conserved 0.0045 0.04 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.2059 0.2386
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1894 0.1894
Brugia malayi MH1 domain containing protein 0.0024 0.0149 0.026
Leishmania major oligopeptidase b 0.017 0.192 0.3775
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.4853 0.4853
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0294 0.0294
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0151 0.0151
Schistosoma mansoni alpha glucosidase 0.0037 0.0308 0.0357
Brugia malayi prolyl oligopeptidase family protein 0.0045 0.04 0.0761
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0072 0.0083
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0149 0.0173
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1976 0.6372
Echinococcus multilocularis prolyl endopeptidase 0.0428 0.5045 0.5045
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.017 0.192 0.3775
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0632 0.1222
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.2059 0.4061
Schistosoma mansoni cpg binding protein 0.0029 0.0207 0.024
Brugia malayi Bromodomain containing protein 0.0077 0.079 0.1536
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.04 0.0749
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3087 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0518 0.0994
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0518 0.06
Leishmania major hypothetical protein, conserved 0.0026 0.0177 0.0303
Brugia malayi MH1 domain containing protein 0.0024 0.0149 0.026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0632 0.0632
Echinococcus multilocularis Smad4 0.0024 0.0149 0.0149
Trypanosoma cruzi oligopeptidase b 0.017 0.192 0.3775
Echinococcus granulosus geminin 0.0171 0.1926 0.2231
Schistosoma mansoni smad1 5 8 and 0.0024 0.0149 0.0173
Brugia malayi PHD-finger family protein 0.0027 0.018 0.0322
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0049
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0045 0.04 0.0749
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3087 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0308 0.0927
Loa Loa (eye worm) hypothetical protein 0.0119 0.1299 0.2548
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0185 0.2099 0.2099
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0308 0.0578
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0185 0.2099 0.2431
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0064 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.2059 0.2386
Schistosoma mansoni bromodomain containing protein 0.0065 0.0647 0.075
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.017 0.192 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.2099 0.2431
Echinococcus multilocularis cpg binding protein 0.0033 0.025 0.025
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1976 0.6372
Trypanosoma brucei oligopeptidase b 0.017 0.192 0.3775
Schistosoma mansoni hypothetical protein 0.0064 0.0632 0.0732
Onchocerca volvulus Huntingtin homolog 0.0119 0.1299 0.2539
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0045 0.04 0.0459
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0045 0.04 0.0749
Trypanosoma cruzi ISWI complex protein 0.0015 0.0043 0.0036
Brugia malayi hypothetical protein 0.0026 0.0177 0.0316
Schistosoma mansoni smad1 5 8 and 0.0024 0.0149 0.0173
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0177 0.0303
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0045 0.04 0.0464
Onchocerca volvulus 0.0048 0.0438 0.0822
Brugia malayi mbt repeat family protein 0.0048 0.0438 0.0834
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0064 0.0074
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0308 0.0271
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.2099 0.2431
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0604 0.0699
Echinococcus multilocularis GPCR, family 2 0.0064 0.0632 0.0632
Schistosoma mansoni hypothetical protein 0.0171 0.1926 0.2231
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.2059 0.2059
Echinococcus granulosus prolyl endopeptidase 0.0428 0.5045 0.5845
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0203 0.2309 0.4557
Echinococcus multilocularis microtubule associated protein 2 0.0725 0.8632 0.8632
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0177 0.0303
Schistosoma mansoni microtubule-associated protein tau 0.0725 0.8632 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.1894 0.2194
Trypanosoma brucei prolyl oligopeptidase, putative 0.017 0.192 0.3775
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0045 0.04 0.0464
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0045 0.04 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0149 0.0173
Brugia malayi Smad1 0.0024 0.0149 0.026
Entamoeba histolytica prolyl oligopeptidase family protein 0.0045 0.04 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.04 0.1227
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0438 0.0507
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0045 0.04 0.1227
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0045 0.04 0.0749
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0107
Brugia malayi MH2 domain containing protein 0.0355 0.4153 0.8225
Brugia malayi prolyl oligopeptidase family protein 0.0045 0.04 0.0761
Giardia lamblia Alanyl dipeptidyl peptidase 0.0045 0.04 0.5
Trypanosoma brucei glucosidase, putative 0.0037 0.0308 0.0565
Loa Loa (eye worm) hypothetical protein 0.0048 0.0438 0.0834
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0308 0.0927
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3087 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0177 0.0316
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.1894 0.3732
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.2059 0.2386

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.7 mM Inhibition of Trypanosoma cruzi trans-sialidase after 15 mins ChEMBL. 17292612

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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