Detailed information for compound 503132

Basic information

Technical information
  • TDR Targets ID: 503132
  • Name: 2-[[4-[4-(3-ethoxyphenyl)-3-methylphenyl]-3,6 -dihydro-2H-pyridin-1-yl]sulfonyl]-N-hydroxya cetamide
  • MW: 430.517 | Formula: C22H26N2O5S
  • H donors: 2 H acceptors: 4 LogP: 2.57 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cccc(c1)c1ccc(cc1C)C1=CCN(CC1)S(=O)(=O)CC(=O)NO
  • InChi: 1S/C22H26N2O5S/c1-3-29-20-6-4-5-19(14-20)21-8-7-18(13-16(21)2)17-9-11-24(12-10-17)30(27,28)15-22(25)23-26/h4-9,13-14,26H,3,10-12,15H2,1-2H3,(H,23,25)
  • InChiKey: JYHCJUBSWRQINP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-[4-(3-ethoxyphenyl)-3-methyl-phenyl]-3,6-dihydro-2H-pyridin-1-yl]sulfonyl]ethanehydroxamic acid
  • 2-[[4-[4-(3-ethoxyphenyl)-3-methylphenyl]-3,6-dihydro-2H-pyridin-1-yl]sulfonyl]ethanehydroxamic acid
  • 2-[[4-[4-(3-ethoxyphenyl)-3-methyl-phenyl]-3,6-dihydro-2H-pyridin-1-yl]sulfonyl]-N-hydroxy-ethanamide
  • 2-[[4-(3-methyl-4-m-phenetyl-phenyl)-3,6-dihydro-2H-pyridin-1-yl]sulfonyl]ethanehydroxamic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 3 (stromelysin 1, progelatinase) 477 aa 431 aa 34.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0073 0.013
Plasmodium falciparum mitogen-activated protein kinase 2 0.0338 0.3739 0.3731
Echinococcus multilocularis muscleblind protein 0.0309 0.3405 0.3586
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0553 0.4737
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Onchocerca volvulus Matrilysin homolog 0.0105 0.1082 0.3931
Onchocerca volvulus Cell death protein 3 homolog 0.0086 0.0869 0.3156
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0065 0.0065
Brugia malayi glutathione reductase 0.0047 0.0419 0.1232
Toxoplasma gondii sugar transporter ST1 0.0029 0.0219 0.0327
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0416 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0433 0.3708
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0394 0.1427
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0012 0.0018 0.0016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0732 0.0768
Onchocerca volvulus 0.0059 0.0558 0.2023
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0011 0.0012 0.0084
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0012 0.0018 0.0058
Brugia malayi kap beta 3 protein 0.0011 0.0012 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.1105 0.202
Echinococcus granulosus translational activator gcn1 0.0011 0.0012 0.001
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0599 0.1758
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.1105 0.202
Brugia malayi steroid hormone receptor 0.001 0.0003 0.0008
Onchocerca volvulus 0.0029 0.0219 0.0786
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0219 0.0643
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0152 0.0209
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0118 0.1233 0.1297
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.1165 1
Plasmodium vivax glycine--tRNA ligase, putative 0.0012 0.0018 0.0006
Onchocerca volvulus 0.0029 0.0219 0.0786
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0012 0.0018 0.0053
Onchocerca volvulus 0.0013 0.0033 0.0109
Leishmania major hypothetical protein, conserved 0.0011 0.0012 0.0084
Echinococcus granulosus importin subunit beta 1 0.0059 0.0562 0.0589
Leishmania major glucose transporter, lmgt1 0.0065 0.0623 0.5335
Brugia malayi Thioredoxin reductase 0.0047 0.0419 0.1232
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0268 0.0965
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0732 0.0768
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0419 0.0408
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0045 0.0394 0.0413
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0416 0.1221
Onchocerca volvulus 0.0029 0.0219 0.0786
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0112 0.1165 0.4234
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0394 0.0383
Trypanosoma cruzi metacaspase, putative 0.0045 0.0394 0.337
Loa Loa (eye worm) hypothetical protein 0.0064 0.0619 0.0865
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0033 0.0031
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0037 0.0125
Brugia malayi Matrixin family protein 0.0047 0.0424 0.1246
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Echinococcus multilocularis geminin 0.0513 0.5741 0.6048
Plasmodium vivax SET domain protein, putative 0.0033 0.0258 0.0246
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0599 0.5086
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0219 0.0228
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0383 0.3272
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0717 0.0706
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0268 0.0966
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Brugia malayi Matrixin family protein 0.0047 0.0424 0.1246
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0209 0.2266 0.2386
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0619 0.0865
Echinococcus multilocularis pyruvate kinase 0.0017 0.0081 0.0082
Loa Loa (eye worm) hypothetical protein 0.0059 0.0562 0.0785
Loa Loa (eye worm) matrix metalloproteinase 0.0047 0.0424 0.0592
Plasmodium falciparum hexose transporter 0.0209 0.2266 0.2257
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0516 0.0541
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.1328 0.1396
Loa Loa (eye worm) hypothetical protein 0.0309 0.3405 0.478
Schistosoma mansoni hypothetical protein 0.0634 0.712 0.7502
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0516 0.8574
Giardia lamblia Pyruvate kinase 0.0034 0.0268 0.4303
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0623 0.5335
Echinococcus granulosus transportin 1 0.0011 0.0012 0.001
Schistosoma mansoni myo inositol monophosphatase 0.0012 0.0018 0.0016
Mycobacterium leprae POSSIBLE MONOPHOSPHATASE CYSQ 0.0012 0.0018 0.0128
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0288 0.2455
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0383 0.0534
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0457 0.0478
Schistosoma mansoni importin-beta 2 0.0011 0.0012 0.001
Onchocerca volvulus Huntingtin homolog 0.0126 0.1318 0.4787
Schistosoma mansoni hypothetical protein 0.0513 0.5741 0.6048
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0219 0.0788
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0516 0.4416
Echinococcus multilocularis pyruvate kinase 0.0017 0.0081 0.0082
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0562 0.4811
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0073 0.0611
Leishmania major hypothetical protein, conserved 0.0029 0.0219 0.1862
Mycobacterium tuberculosis Conserved protein 0.0077 0.0757 0.1382
Plasmodium falciparum metacaspase 1 0.0045 0.0394 0.0383
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0219 0.1862
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0619 0.0608
Schistosoma mansoni caspase-7 (C14 family) 0.0086 0.0869 0.0913
Schistosoma mansoni hypothetical protein 0.0513 0.5741 0.6048
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0757 0.2749
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0394 0.1427
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0012 0.0015
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0018 0.0134
Onchocerca volvulus 0.0047 0.0424 0.1535
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.151 0.1588
Onchocerca volvulus 0.0029 0.0219 0.0786
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0112 0.1165 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0619 0.0649
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0045 0.0394 0.1158
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0394 0.1427
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1032 0.1446
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0757 0.0795
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.0018 0.0006
Schistosoma mansoni hypothetical protein 0.0032 0.0247 0.0257
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0069 0.0578
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0112 0.1165 1
Brugia malayi Sugar transporter family protein 0.0029 0.0219 0.0643
Echinococcus multilocularis transportin 1 0.0011 0.0012 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0394 0.1427
Brugia malayi Cytochrome P450 family protein 0.0046 0.0414 0.1216
Onchocerca volvulus 0.0029 0.0219 0.0786
Trypanosoma cruzi metacaspase, putative 0.0045 0.0394 0.337
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0219 0.1862
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0383 0.0371
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0516 0.4416
Echinococcus granulosus caspase 2 0.0086 0.0869 0.0913
Toxoplasma gondii ABC1 family protein 0.0077 0.0757 0.1141
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0383 0.0575
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0757 0.0746
Schistosoma mansoni hypothetical protein 0.0012 0.0018 0.0016
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.1105 0.202
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0069 0.0578
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0394 0.1427
Schistosoma mansoni single-minded 0.005 0.0457 0.0478
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0012 0.0018 0.0016
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2266 0.2386
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0219 0.0643
Trypanosoma brucei metacaspase MCA3 0.0045 0.0394 0.337
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Schistosoma mansoni hypothetical protein 0.0032 0.0247 0.0257
Echinococcus multilocularis inositol monophosphatase 0.0012 0.0018 0.0016
Onchocerca volvulus 0.0033 0.0258 0.0928
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0394 0.1427
Entamoeba histolytica Ran family GTPase 0.0044 0.0383 0.3215
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0219 0.0303
Echinococcus multilocularis pyruvate kinase 0.0017 0.0081 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0037 0.0125
Plasmodium falciparum glutathione reductase 0.0016 0.0069 0.0057
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.1105 0.202
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0562 0.4811
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0717 0.6146
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0335 0.061
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0394 0.0592
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0757 0.1382
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0757 0.6493
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0619 0.0608
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0619 0.0932
Schistosoma mansoni hypothetical protein 0.0032 0.0247 0.0257
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0069 0.0578
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0112 0.1165 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0069 0.0578
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0069 0.0578
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0219 0.0228
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Mycobacterium ulcerans sugar transporter 0.0029 0.0219 0.1862
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0219 0.1862
Echinococcus multilocularis caspase 2 0.0086 0.0869 0.0913
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0623 0.5335
Leishmania major pyruvate kinase 0.0034 0.0268 0.2283
Echinococcus multilocularis expressed protein 0.0017 0.0073 0.0074
Schistosoma mansoni cpg binding protein 0.0059 0.0558 0.0586
Echinococcus granulosus caspase 8 0.0045 0.0394 0.0413
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Schistosoma mansoni ran 0.0044 0.0383 0.04
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0033 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0003 0.0008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.151 0.1588
Trypanosoma brucei glucose transporter, putative 0.0065 0.0623 0.5335
Onchocerca volvulus Matrilysin homolog 0.0047 0.0424 0.1535
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0012 0.0018 0.0136
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0599 0.2171
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0562 0.0845
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0268 0.0965
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0219 0.1862
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0599 0.1758
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0623 0.5335
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0219 0.0788
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0033 0.0111
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0247 0.0726
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Schistosoma mansoni sugar transporter 0.0029 0.0219 0.0228
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0268 0.0372
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0394 0.1427
Trypanosoma brucei glucose transporter, putative 0.0065 0.0623 0.5335
Loa Loa (eye worm) hypothetical protein 0.0058 0.0542 0.0758
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0553 0.058
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0619 0.0649
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0757 0.2224
Loa Loa (eye worm) hypothetical protein 0.0034 0.0268 0.0372
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0619 0.0649
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0623 0.2259
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0268 0.0372
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0069 0.0578
Mycobacterium tuberculosis Conserved protein 0.0077 0.0757 0.1382
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0757 0.2749
Loa Loa (eye worm) sugar transporter 0.0209 0.2266 0.318
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0018 0.0057
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0219 0.1862
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0717 0.6146
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0101 0.1031 0.8298
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0516 0.0541
Brugia malayi hypothetical protein 0.0168 0.1805 0.5302
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0069 0.0578
Schistosoma mansoni hypothetical protein 0.0842 0.9489 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0172 0.1849 0.1946
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0003 0.0008
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0018 0.0134
Trypanosoma brucei glucose transporter, putative 0.0065 0.0623 0.5335
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0757 0.0795
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0018 0.0052
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0619 0.0649
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0037 0.0125
Plasmodium falciparum glutathione reductase 0.0047 0.0419 0.0408
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.1242 0.2269
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0757 0.6493
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0258 0.0269
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0553 0.058
Schistosoma mansoni pyruvate kinase 0.0034 0.0268 0.0279
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0568 0.0596
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0383 0.6283
Schistosoma mansoni ferritin light chain 0.0017 0.0073 0.0074
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0118 0.1233 0.1297
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0033 0.0031
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0416 0.3554
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0016 0.0063 0.0521
Onchocerca volvulus 0.0029 0.0219 0.0786
Brugia malayi hypothetical protein 0.0029 0.0219 0.0643
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0219 0.0327
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0018 0.0084 0.0699
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0416 0.3334
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.151 0.1588
Schistosoma mansoni ferritin 0.0017 0.0073 0.0074
Onchocerca volvulus Putative transporter 0.0029 0.0219 0.0786
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2266 0.2386
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0394 0.1427
Brugia malayi Cell death protein 3 precursor 0.0086 0.0869 0.2554
Brugia malayi nuclear receptor NHR-88 0.001 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0258 0.0358
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Loa Loa (eye worm) hypothetical protein 0.0047 0.0424 0.0592
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0219 0.0228
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0599 0.0628
Toxoplasma gondii facilitative glucose transporter GT1 0.0209 0.2266 0.3421
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0012 0.0013
Onchocerca volvulus 0.0077 0.0757 0.2747
Plasmodium vivax glutathione reductase, putative 0.0047 0.0419 0.0408
Leishmania major GTP-binding protein, putative 0.0044 0.0383 0.3272
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0069 0.007
Leishmania major hypothetical protein, conserved 0.0077 0.0757 0.6493
Mycobacterium leprae Probable monophosphatase 0.0012 0.0018 0.0128
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0416 0.0435
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0416 0.3554
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Onchocerca volvulus 0.0029 0.0219 0.0786
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0416 0.3554
Trypanosoma brucei glucose transporter, putative 0.0065 0.0623 0.5335
Brugia malayi CXXC zinc finger family protein 0.0059 0.0558 0.164
Onchocerca volvulus 0.0029 0.0219 0.0786
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.0394 0.337
Brugia malayi beta-lactamase 0.0077 0.0757 0.2224
Brugia malayi Inositol monophosphatase family protein 0.0012 0.0018 0.0053
Mycobacterium ulcerans hydrolase 0.0058 0.0542 0.4642
Trypanosoma brucei glucose transporter, putative 0.0065 0.0623 0.5335
Echinococcus multilocularis caspase 8 0.0045 0.0394 0.0413
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0069 0.0888
Onchocerca volvulus 0.0077 0.0757 0.2747
Toxoplasma gondii protein kinase, putative 0.059 0.662 1
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0012 0.0018 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0003 0.0008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0553 0.1008
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0833 0.9387 0.9892
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0018 0.0016
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0112 0.1165 0.1757
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0069 0.0578
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0717 0.108
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0419 0.0585
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0037 0.0125
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0416 0.3554
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.1175 0.1772
Echinococcus granulosus expressed protein 0.0017 0.0073 0.0074
Echinococcus multilocularis pyruvate kinase 0.0034 0.0268 0.0279
Plasmodium vivax sugar transporter, putative 0.0029 0.0219 0.0207
Schistosoma mansoni hypothetical protein 0.0042 0.0359 0.0376
Schistosoma mansoni pyruvate kinase 0.0017 0.0081 0.0082
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0757 0.1382
Echinococcus granulosus pyruvate kinase 0.0034 0.0268 0.0279
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0247 0.0257
Loa Loa (eye worm) sugar transporter 0.0029 0.0219 0.0303
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0073 0.0611
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0012 0.0018 0.0136
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0414 0.0578
Echinococcus granulosus pyruvate kinase 0.0017 0.0081 0.0082
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0268 0.2283
Echinococcus granulosus inositol monophosphatase 0.0012 0.0018 0.0016
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.1242 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0424 0.0592
Giardia lamblia Pyruvate kinase 0.0017 0.0081 0.1085
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0069 0.0578
Onchocerca volvulus 0.0029 0.0219 0.0786
Entamoeba histolytica hypothetical protein 0.0074 0.0732 0.6242
Schistosoma mansoni sugar transporter 0.0029 0.0219 0.0228
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0553 0.4737
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0037 0.0125
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0112 0.1165 0.4234
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0219 0.1862
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0069 0.0578
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0136 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0069 0.0057
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0033 0.0262
Schistosoma mansoni inositol monophosphatase 0.0112 0.1165 0.1225
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0033 0.0111
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0623 0.2259
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0394 0.1427
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0012 0.0018 0.0056
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.0394 0.337
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.002 0.0059
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0383 0.3272
Onchocerca volvulus 0.0029 0.0219 0.0786
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0623 0.5335
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0073 0.013
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0152 0.121
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0416 0.0404
Loa Loa (eye worm) hypothetical protein 0.0077 0.0757 0.106
Brugia malayi major facilitator superfamily protein 0.0029 0.0219 0.0643
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0717 0.0706
Echinococcus multilocularis cpg binding protein 0.0062 0.0597 0.0626
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0219 0.0228
Brugia malayi hypothetical protein 0.0042 0.0359 0.1055
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0394 0.1427
Loa Loa (eye worm) hypothetical protein 0.0077 0.0757 0.106
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0069 0.0057
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0516 0.4416
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0069 0.0578
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0619 0.2244
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0219 0.0788
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0419 0.3587
Loa Loa (eye worm) hypothetical protein 0.0077 0.0757 0.106
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0717 0.6146
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0018 0.0016
Schistosoma mansoni hypothetical protein 0.0067 0.065 0.0682
Mycobacterium ulcerans beta-lactamase 0.0077 0.0757 0.6493
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0219 0.0643
Echinococcus multilocularis General substrate transporter 0.0179 0.1931 0.2033
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0012 0.0018 0.0136
Trichomonas vaginalis hypothetical protein 0.0011 0.0012 0.0036
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0619 0.0649
Chlamydia trachomatis pyruvate kinase 0.0034 0.0268 0.6282
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0732 0.0768
Brugia malayi nuclear hormone receptor 0.001 0.0003 0.0008
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Loa Loa (eye worm) hypothetical protein 0.0126 0.1318 0.1847
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0106 0.0145
Trypanosoma brucei glucose transporter, putative 0.0065 0.0623 0.5335
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0219 0.0396
Loa Loa (eye worm) hypothetical protein 0.0309 0.3405 0.478
Leishmania major metacaspase, putative 0.0045 0.0394 0.337
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0037 0.0125
Entamoeba histolytica hypothetical protein 0.0074 0.0732 0.6242
Plasmodium vivax CDK-related protein kinase 6, putative 0.0887 1 1
Schistosoma mansoni pyruvate kinase 0.0034 0.0268 0.0279
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0553 0.058
Schistosoma mansoni protein kinase 0.0064 0.0619 0.0649
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0394 0.1427
Echinococcus granulosus geminin 0.0513 0.5741 0.6048
Mycobacterium leprae Probable lipase LipE 0.0077 0.0757 0.6091
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0003 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0037 0.0125
Echinococcus granulosus single minded 2 0.0037 0.0308 0.0321
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0018 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Entamoeba histolytica protein kinase, putative 0.0064 0.0619 0.5261
Plasmodium falciparum thioredoxin reductase 0.0047 0.0419 0.0408
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0219 0.0788
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0599 0.0628
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0308 0.2627
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0619 0.0649
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0416 0.0625
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0018 0.0024
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0268 0.2283
Loa Loa (eye worm) hypothetical protein 0.0077 0.0757 0.106
Loa Loa (eye worm) hypothetical protein 0.0042 0.0359 0.0501
Schistosoma mansoni ferritin 0.0017 0.0073 0.0074
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0069 0.0578
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0018 0.0134
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0516 0.187
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0757 0.1382
Trichomonas vaginalis inositol monophosphatase, putative 0.0012 0.0018 0.0058
Schistosoma mansoni ran 0.0044 0.0383 0.04
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0619 0.0649
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0623 0.2259
Loa Loa (eye worm) hypothetical protein 0.0047 0.0416 0.058
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0012 0.0018 0.0006
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0069 0.0449
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0619 0.0932
Loa Loa (eye worm) hypothetical protein 0.0032 0.0247 0.0343
Brugia malayi hypothetical protein 0.0074 0.0732 0.2149
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0489 0.5464 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0219 0.0788
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0516 0.187
Plasmodium falciparum importin beta, putative 0.0059 0.0562 0.055
Trypanosoma brucei trypanothione reductase 0.0047 0.0419 0.3587
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0069 0.0123
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0103 0.0303
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0069 0.0101
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0033 0.0262
Schistosoma mansoni caspase-7 (C14 family) 0.0118 0.1233 0.1297
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0516 0.4416
Mycobacterium tuberculosis Probable monophosphatase 0.0012 0.0018 0.0029
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0516 0.0541
Brugia malayi hypothetical protein 0.0029 0.0219 0.0643
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0219 0.0207
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0558 0.078
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0012 0.0015
Brugia malayi MAP kinase sur-1 0.0055 0.0516 0.1515
Mycobacterium tuberculosis Conserved protein 0.0077 0.0757 0.1382
Echinococcus granulosus General substrate transporter 0.0179 0.1931 0.2033
Loa Loa (eye worm) hypothetical protein 0.0086 0.0869 0.1218
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0037 0.0125
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0599 0.481
Schistosoma mansoni ferritin 0.0017 0.0073 0.0074
Schistosoma mansoni hypothetical protein 0.0074 0.0732 0.0768
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0619 0.0932
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0394 0.0592
Schistosoma mansoni ferritin 0.0017 0.0073 0.0074
Echinococcus granulosus solute carrier family 22 0.0029 0.0219 0.0228
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0619 0.0649
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0003 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0037 0.0125
Leishmania major protein kinase, putative 0.0018 0.0084 0.0699
Echinococcus multilocularis snurportin 1 0.0634 0.712 0.7502
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0219 0.0788
Plasmodium vivax hexose transporter 0.0209 0.2266 0.2257
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0258 0.0269
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0419 0.0764
Brugia malayi hypothetical protein 0.0029 0.0219 0.0643
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0021
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0047 0.0424 0.0444
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0069 0.0204
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0247 0.0257
Toxoplasma gondii sugar transporter ST2 0.0029 0.0219 0.0327
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0069 0.0057
Schistosoma mansoni inositol monophosphatase 0.0112 0.1165 0.1225
Leishmania major trypanothione reductase 0.0047 0.0419 0.3587
Echinococcus multilocularis solute carrier family 22 0.0029 0.0219 0.0228
Echinococcus multilocularis inositol monophosphatase 1 0.0112 0.1165 0.1225
Toxoplasma gondii sugar transporter ST3 0.0029 0.0219 0.0327
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0018 0.0126
Schistosoma mansoni hypothetical protein 0.0012 0.0018 0.0016
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0081 0.0119
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1032 0.3031
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0335 0.2688
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0219 0.0303
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.151 0.1588
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0012 0.0018 0.0053
Brugia malayi Sugar transporter family protein 0.0209 0.2266 0.6656
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0383 0.04
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0516 0.0541
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2266 0.2386
Loa Loa (eye worm) glutathione reductase 0.0047 0.0419 0.0585
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0757 0.6493
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0383 0.04
Schistosoma mansoni protein kinase 0.0064 0.0619 0.0649
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0516 0.4416
Loa Loa (eye worm) hypothetical protein 0.0126 0.1318 0.1847
Brugia malayi Muscleblind-like protein 0.0309 0.3405 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.1165 1
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0416 0.3554
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0081 0.0069
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0018 0.0084 0.0699
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.151 0.1588
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0069 0.0578
Echinococcus granulosus pyruvate kinase 0.0034 0.0268 0.0279
Loa Loa (eye worm) matrixin family protein 0.0105 0.1082 0.1517
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0268 0.0401
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0003 0.0008
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0516 0.4416
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0757 0.2749
Toxoplasma gondii hypothetical protein 0.0012 0.0018 0.0024
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0136 0.1153
Brugia malayi ecdysteroid receptor 0.001 0.0003 0.0008
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0599 0.0628
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0065 0.0065
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0416 0.1505
Schistosoma mansoni hypothetical protein 0.0209 0.2266 0.2386
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0669 0.1964
Loa Loa (eye worm) hypothetical protein 0.0063 0.0599 0.0837
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0037 0.0125
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0033 0.0042
Trypanosoma brucei glucose transporter, putative 0.0065 0.0623 0.5335
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0433 0.157
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0003 0.0008
Echinococcus multilocularis dnaJ subfamily B 0.0842 0.9489 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0634 0.712 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0065 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2266 0.8242
Loa Loa (eye worm) hypoxia-induced factor 1 0.0155 0.1656 0.2323
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0268 0.2283
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2266 0.2386
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.1242 0.2269
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0359 0.0376
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0394 0.1427
Echinococcus multilocularis solute carrier family 22 0.0029 0.0219 0.0228
Schistosoma mansoni caspase-3 (C14 family) 0.0118 0.1233 0.1297
Echinococcus granulosus GPCR family 2 0.0032 0.0247 0.0257
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0018 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0623 0.2259
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0247 0.0257
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0757 0.1382
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0018 0.0052
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0012 0.0018 0.0136
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0619 0.53
Echinococcus granulosus pyruvate kinase 0.0017 0.0081 0.0082
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0069 0.0578
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0219 0.1862
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0394 0.1427
Echinococcus multilocularis GPCR, family 2 0.0032 0.0247 0.0257
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0268 0.0486
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0258 0.0386
Brugia malayi beta-lactamase family protein 0.0077 0.0757 0.2224
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0018 0.0134
Schistosoma mansoni hypothetical protein 0.0069 0.0669 0.0702
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0619 0.0608
Brugia malayi hypothetical protein 0.0126 0.1318 0.387
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0383 0.1124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0037 0.0125
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0757 0.1382
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0219 0.1751
Schistosoma mansoni pap-inositol-14-phosphatase 0.0012 0.0018 0.0016
Plasmodium vivax metacaspase 1, putative 0.0045 0.0394 0.0383
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0258 0.0269
Echinococcus granulosus caspase 3 0.0074 0.0723 0.0759
Onchocerca volvulus 0.0029 0.0219 0.0786
Loa Loa (eye worm) hypothetical protein 0.0013 0.0033 0.0042
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0033 0.0262
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0553 0.4737
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.1105 0.89
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0359 0.0376
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0003 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0033 0.0111
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0021
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0136 0.2978
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0416 0.0435
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0018 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0516 0.187
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0018 0.0029
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0383 0.0371
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0058 0.0542 0.1592
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0065 0.0065
Leishmania major protein kinase, putative 0.0064 0.0619 0.53
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0069 0.007
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0623 0.2259
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0619 0.0649
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.151 0.4434
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0516 0.4416
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0757 0.0795
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0619 0.0608
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0757 0.6493
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0247 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0003 0.0008
Onchocerca volvulus 0.0029 0.0219 0.0786
Trypanosoma cruzi hexose transporter 0.0065 0.0623 0.5335
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0623 0.5335
Mycobacterium tuberculosis Probable reductase 0.0107 0.1105 0.202
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0599 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0258 0.0269
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0033 0.0111
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0268 0.0256
Trypanosoma brucei glucose transporter 1E 0.0065 0.0623 0.5335
Echinococcus granulosus pyruvate kinase 0.0017 0.0081 0.0082
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Mycobacterium ulcerans hypothetical protein 0.0077 0.0757 0.6493
Giardia lamblia Hypothetical protein 0.0012 0.0018 0.0004
Echinococcus granulosus caspase 0.0118 0.1233 0.1297
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0018 0.0024
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0338 0.3739 0.3731
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0268 0.0786
Trypanosoma brucei metacaspase 0.0045 0.0394 0.337
Mycobacterium leprae PROBABLE HYDROLASE 0.0058 0.0542 0.4355
Brugia malayi Inositol monophosphatase family protein 0.0012 0.0018 0.0053
Loa Loa (eye worm) hypothetical protein 0.0051 0.0465 0.0649
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0619 0.0865
Schistosoma mansoni glucose transport protein 0.0209 0.2266 0.2386
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0717 0.6146
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0619 0.0608
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0033 0.0031
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0101 0.1031 0.1883
Onchocerca volvulus Huntingtin homolog 0.0126 0.1318 0.4787
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0516 0.187
Onchocerca volvulus 0.0037 0.0308 0.111
Schistosoma mansoni hypothetical protein 0.0032 0.0247 0.0257
Brugia malayi beta-lactamase family protein 0.0077 0.0757 0.2224
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0003 0.0008
Treponema pallidum NADH oxidase 0.0016 0.0069 0.4354
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0033 0.0031
Loa Loa (eye worm) beta-lactamase 0.0077 0.0757 0.106
Brugia malayi PAS domain containing protein 0.005 0.0457 0.1341
Leishmania major myo-inositol-1 phosphatase, putative 0.0012 0.0018 0.0136
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2266 0.2386
Brugia malayi hypoxia-induced factor 1 0.0155 0.1656 0.4865
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0619 0.0608
Echinococcus multilocularis caspase 3 0.0074 0.0723 0.0759
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0335 0.061
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0073 0.0483
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0012 0.0018 0.0051
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0568 0.0596
Leishmania major protein kinase, putative 0.0018 0.0084 0.0699
Brugia malayi Pre-SET motif family protein 0.0033 0.0258 0.0757
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0037 0.0125
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.023 0.0239
Leishmania major pyruvate kinase 0.0034 0.0268 0.2283
Entamoeba histolytica hypothetical protein 0.0074 0.0732 0.6242
Echinococcus granulosus cpg binding protein 0.0062 0.0597 0.0626
Echinococcus multilocularis pyruvate kinase 0.0027 0.0187 0.0194
Loa Loa (eye worm) hypothetical protein 0.0168 0.1805 0.2533
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0619 0.0608
Schistosoma mansoni ferritin light chain 0.0017 0.0073 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0003 0.0008
Mycobacterium leprae Possible regulatory protein 0.0013 0.0033 0.0245
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0018 0.0134
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0268 0.0966
Mycobacterium ulcerans monophosphatase CysQ 0.0012 0.0018 0.0136
Loa Loa (eye worm) hypothetical protein 0.0077 0.0757 0.106
Loa Loa (eye worm) hypothetical protein 0.0077 0.0757 0.106
Leishmania major importin beta-1 subunit, putative 0.0048 0.0433 0.3708
Loa Loa (eye worm) hypothetical protein 0.0063 0.0599 0.0837
Loa Loa (eye worm) matrixin family protein 0.0115 0.1191 0.1669
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0619 0.0608
Echinococcus granulosus solute carrier family 22 0.0029 0.0219 0.0228
Entamoeba histolytica hypothetical protein 0.0047 0.0416 0.35
Echinococcus multilocularis muscleblind protein 1 0.0309 0.3405 0.3586
Brugia malayi RNA, U transporter 1 0.0169 0.1811 0.532
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0037 0.0125
Entamoeba histolytica hypothetical protein 0.0048 0.0433 0.3655
Schistosoma mansoni glucose transport protein 0.0209 0.2266 0.2386
Loa Loa (eye worm) inositol-1 0.0112 0.1165 0.1633
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0219 0.0228
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0433 0.157
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0623 0.2259
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Brugia malayi Sugar transporter family protein 0.0029 0.0219 0.0643
Echinococcus multilocularis pyruvate kinase 0.0034 0.0268 0.0279
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0268 0.2283
Giardia lamblia Sugar-proton symporter 0.0029 0.0219 0.346
Plasmodium vivax importin-beta 2, putative 0.0059 0.0562 0.055
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0338 0.3739 0.5646
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0003 0.0008
Mycobacterium ulcerans lipase LipD 0.0077 0.0757 0.6493
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0268 0.0965
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2266 0.2386
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0553 0.0832
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0247 0.0257
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0757 0.0795
Plasmodium falciparum thioredoxin reductase 0.0016 0.0069 0.0057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0424 0.0592
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0037 0.0125
Trichomonas vaginalis esterase, putative 0.0077 0.0757 0.2749
Mycobacterium tuberculosis Monophosphatase CysQ 0.0012 0.0018 0.0029
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.005 0.0454 0.0476
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.1165 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0069 0.1296
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0394 0.1427
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0033 0.0111
Onchocerca volvulus 0.0029 0.0219 0.0786
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0553 0.058
Leishmania major glucose transporter, lmgt3 0.0065 0.0623 0.5335
Plasmodium vivax threonine--tRNA ligase, putative 0.0012 0.0018 0.0006
Trypanosoma brucei sugar transporter, putative 0.0029 0.0219 0.1862
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0012 0.0018 0.0136
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0033 0.0373
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0757 0.1382
Echinococcus granulosus muscleblind protein 0.0309 0.3405 0.3586
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0069 0.0578
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0416 0.0404
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0018 0.0016
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0623 0.2259
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0268 0.0372
Schistosoma mansoni sugar transporter 0.0029 0.0219 0.0228
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0757 0.6493
Echinococcus granulosus solute carrier family 22 0.0029 0.0219 0.0228
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0069 0.0578
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0757 0.6091
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0045 0.0394 0.055
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0247 0.0726
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0757 0.106
Trypanosoma brucei protein kinase, putative 0.0055 0.0516 0.4416
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Trichomonas vaginalis set domain proteins, putative 0.0251 0.2749 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.002 0.0059
Echinococcus multilocularis translational activator gcn1 0.0011 0.0012 0.001
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0717 0.6146
Onchocerca volvulus 0.0029 0.0219 0.0786
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2266 0.2386
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.1242 0.2269
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0018 0.0084 0.0699
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0033 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0033 0.0111
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0003 0.0008
Schistosoma mansoni cpg binding protein 0.0062 0.0597 0.0626
Echinococcus granulosus dnaJ subfamily B 0.0842 0.9489 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0012 0.0018 0.0058
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0073 0.4681
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0069 0.0057
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.035 0.1266
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0219 0.1862
Schistosoma mansoni glucose transport protein 0.0209 0.2266 0.2386
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Schistosoma mansoni apoferritin-2 0.0017 0.0073 0.0074
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0383 0.3272
Brugia malayi Cam kinase protein 1 0.0064 0.0619 0.1817
Loa Loa (eye worm) hypothetical protein 0.0069 0.0669 0.0935
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0069 0.0449
Entamoeba histolytica hypothetical protein 0.0074 0.0732 0.6242
Schistosoma mansoni cpg binding protein 0.0062 0.0597 0.0626
Onchocerca volvulus 0.0029 0.0219 0.0786
Giardia lamblia Hexose transporter 0.0029 0.0219 0.346
Plasmodium falciparum pyruvate kinase 0.0034 0.0268 0.0256
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0177 0.0245
Mycobacterium ulcerans monophosphatase CysQ 0.0012 0.0018 0.0136
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0065 0.0065
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0003 0.0008
Echinococcus multilocularis importin 5 0.0011 0.0012 0.001
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0516 0.0541
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0258 0.0269
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0069 0.007
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0081 0.0069
Toxoplasma gondii thioredoxin reductase 0.0047 0.0419 0.063
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0037 0.0125
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Echinococcus granulosus ferritin 0.0017 0.0073 0.0074
Plasmodium falciparum metacaspase-like protein 0.0045 0.0394 0.0383
Onchocerca volvulus Matrix metalloproteinase homolog 0.0105 0.1082 0.3931
Brugia malayi Inositol-1 0.0112 0.1165 0.3422
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0258 0.0269
Schistosoma mansoni sugar transporter 0.0029 0.0219 0.0228
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0106 0.0108
Brugia malayi Pre-SET motif family protein 0.0221 0.2403 0.7058
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0757 0.2749
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0069 0.0578
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0012 0.0018 0.0136
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0219 0.0396
Onchocerca volvulus 0.0251 0.2749 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0003 0.0008
Schistosoma mansoni importin beta-1 0.0059 0.0562 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0037 0.0125
Brugia malayi Hemopexin family protein 0.0067 0.065 0.1909
Echinococcus granulosus inositol monophosphatase 1 0.0112 0.1165 0.1225
Brugia malayi Matrixin family protein 0.0115 0.1191 0.3497
Onchocerca volvulus 0.0042 0.0359 0.1297
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0619 0.0608
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Mycobacterium ulcerans monophosphatase 0.0012 0.0018 0.0136
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0308 0.0904
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0416 0.0435
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0419 0.0439
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0106 0.0108
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0623 0.5335
Loa Loa (eye worm) hypothetical protein 0.0101 0.1032 0.1446
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0416 0.0435
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.151 0.1588
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0553 0.4737
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0069 0.0578
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0033 0.0111
Loa Loa (eye worm) hypothetical protein 0.0023 0.0152 0.0209
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0562 0.0589
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0172 0.1849 0.1946
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0018 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0394 0.1427
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0219 0.0788
Onchocerca volvulus 0.0067 0.065 0.2357
Trichomonas vaginalis ran, putative 0.0044 0.0383 0.1385
Trypanosoma brucei metacaspase 5, putative 0.0045 0.0394 0.337
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0757 0.2749
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Trichomonas vaginalis helicase, putative 0.0013 0.0037 0.0125
Trichomonas vaginalis ferritin, putative 0.0017 0.0073 0.0259
Trichomonas vaginalis inositol monophosphatase, putative 0.0112 0.1165 0.4234
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1032 0.3031
Trypanosoma brucei Metacaspase-4 0.0045 0.0394 0.337
Brugia malayi Importin beta-1 subunit 0.0059 0.0562 0.165
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0073 0.0573
Trypanosoma cruzi metacaspase, putative 0.0045 0.0394 0.337
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.151 0.2117
Brugia malayi major facilitator superfamily protein 0.0029 0.0219 0.0643
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0268 0.2142
Trypanosoma brucei glucose transporter 2A 0.0065 0.0623 0.5335
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.2403 0.3372
Trypanosoma brucei glucose transporter, putative 0.0065 0.0623 0.5335
Trichomonas vaginalis inositol monophosphatase, putative 0.0012 0.0018 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0258 0.0269
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0018 0.0084 0.0699
Schistosoma mansoni protein kinase 0.0064 0.0619 0.0649
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0069 0.0244
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0069 0.0244
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.1105 0.202
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0268 0.2283
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0018 0.0134
Echinococcus multilocularis solute carrier family 22 0.0029 0.0219 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0219 0.0303
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0268 0.0786
Trypanosoma brucei metacaspase MCA2 0.0045 0.0394 0.337
Schistosoma mansoni glucose transporter 0.0029 0.0219 0.0228
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0069 0.0101
Schistosoma mansoni apoferritin-2 0.0017 0.0073 0.0074
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0623 0.5335
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0599 0.0628
Brugia malayi Matrixin family protein 0.0047 0.0424 0.1246
Echinococcus multilocularis ferritin 0.0017 0.0073 0.0074
Plasmodium falciparum protein kinase 7 0.059 0.662 0.6616
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0308 0.0321
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0416 0.6849
Onchocerca volvulus 0.0029 0.0219 0.0786
Entamoeba histolytica protein kinase, putative 0.0064 0.0619 0.5261
Echinococcus granulosus snurportin 1 0.0634 0.712 0.7502
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0069 0.0578
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0219 0.0788
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0757 0.1382
Leishmania major glucose transporter, lmgt2 0.0065 0.0623 0.5335
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0037 0.0125
Trypanosoma cruzi metacaspase, putative 0.0045 0.0394 0.337
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0419 0.0439
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0433 0.157
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0012 0.0013
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0219 0.0788
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0516 0.0776
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0069 0.0578
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.1165 1
Echinococcus multilocularis caspase 0.0118 0.1233 0.1297
Echinococcus granulosus solute carrier family 22 0.0029 0.0219 0.0228
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0033 0.0111
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0018 0.0016
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0394 0.0592
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0619 0.1817
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.151 0.1588
Brugia malayi Matrixin family protein 0.0047 0.0424 0.1246
Echinococcus multilocularis solute carrier family 22 0.0029 0.0219 0.0228
Echinococcus granulosus importin 5 0.0011 0.0012 0.001
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0033 0.0111
Onchocerca volvulus 0.0077 0.0757 0.2747
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0516 0.0721
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0058 0.0542 0.0988

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4 nM Inhibition of MMP3 (unknown origin) ChEMBL. 18029177
IC50 (binding) = 4 nM Inhibition of MMP3 (unknown origin) ChEMBL. 18029177
IC50 (binding) = 998 nM Inhibition of MMP2 (unknown origin) ChEMBL. 18029177
IC50 (binding) = 998 nM Inhibition of MMP2 (unknown origin) ChEMBL. 18029177
Solubility < 1 ug ml-1 Aqueous solubility of the compound ChEMBL. 18029177

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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