Detailed information for compound 510572

Basic information

Technical information
  • TDR Targets ID: 510572
  • Name: 2-amino-N-benzyl-6-(furan-2-yl)purine-9-carbo xamide
  • MW: 334.332 | Formula: C17H14N6O2
  • H donors: 2 H acceptors: 4 LogP: 1.67 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(c2ccco2)c2c(n1)n(cn2)C(=O)NCc1ccccc1
  • InChi: 1S/C17H14N6O2/c18-16-21-13(12-7-4-8-25-12)14-15(22-16)23(10-20-14)17(24)19-9-11-5-2-1-3-6-11/h1-8,10H,9H2,(H,19,24)(H2,18,21,22)
  • InChiKey: HOIUTDBGOMHLBQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-amino-N-benzyl-6-(2-furyl)purine-9-carboxamide
  • 2-amino-N-benzyl-6-(2-furyl)-9-purinecarboxamide
  • 2-azanyl-6-(furan-2-yl)-N-(phenylmethyl)purine-9-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References
Homo sapiens adenosine A2b receptor Starlite/ChEMBL References
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References
Homo sapiens adenosine A3 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cysteine protease 0.002 0.0101 0.0071
Onchocerca volvulus 0.0077 0.1167 0.2544
Schistosoma mansoni hypothetical protein 0.004 0.0479 0.0479
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0128 0.0128
Echinococcus granulosus Dipeptidyl peptidase 9 0.0027 0.0229 0.0229
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0027 0.0229 0.0229
Brugia malayi beta-lactamase family protein 0.0077 0.1167 0.2544
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0303 0.5419 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0101 0.0117
Loa Loa (eye worm) hypothetical protein 0.0022 0.0128 0.0279
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0692 0.0692
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0377 0.0377
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0027 0.0229 0.0363
Loa Loa (eye worm) hypothetical protein 0.0022 0.0128 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.0233
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0027 0.0229 0.0229
Giardia lamblia Cathepsin B precursor 0.0047 0.0612 1
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0075 0.114 0.2109
Leishmania major hypothetical protein, conserved 0.0077 0.1167 0.2094
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0128 0.0097
Echinococcus multilocularis cpg binding protein 0.0032 0.0327 0.0297
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.3329 0.3309
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0229 0.0351
Plasmodium vivax SET domain protein, putative 0.0032 0.0313 0.0523
Toxoplasma gondii hypothetical protein 0.0049 0.0638 0.1147
Echinococcus granulosus prolyl endopeptidase 0.0258 0.4587 0.4587
Leishmania major cathepsin L-like protease 0.0066 0.0963 0.1716
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.01 0.1602 0.137
Echinococcus multilocularis tissue type plasminogen activator 0.0017 0.004 0.0009
Onchocerca volvulus 0.0077 0.1167 0.2544
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0963 0.1414
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0101 0.0101
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0696 0.1218
Entamoeba histolytica hypothetical protein 0.004 0.0479 0.2627
Onchocerca volvulus Prolyl endopeptidase homolog 0.0258 0.4587 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.1823 0.307
Onchocerca volvulus 0.002 0.0101 0.0221
Leishmania major cathepsin L-like protease 0.002 0.0101 0.0114
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1167 0.2682
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0112 0.1823 0.419
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0625 0.0625
Loa Loa (eye worm) beta-lactamase 0.0077 0.1167 0.2544
Brugia malayi Cathepsin L-like precursor 0.002 0.0101 0.0221
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.052 0.0892
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0162 0.0162
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.1823 0.3313
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.081 0.1477
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0047 0.0612 0.1063
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.1167 0.086
Leishmania major cathepsin L-like protease 0.002 0.0101 0.0114
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1167 0.1167
Onchocerca volvulus Cathepsin F homolog 0.002 0.0101 0.0221
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0279 0.0279
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.2417 0.4214
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.2312 0.2312
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.052 0.0561
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.1167 0.086
Onchocerca volvulus 0.0022 0.0128 0.0279
Onchocerca volvulus 0.002 0.0101 0.0221
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0128 0.0279
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0128 0.0128
Leishmania major trypanothione reductase 0.0038 0.0433 0.0729
Toxoplasma gondii thioredoxin reductase 0.0038 0.0433 0.0753
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0692 0.0692
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.038 0.035
Toxoplasma gondii cathepsin CPL 0.002 0.0101 0.0117
Toxoplasma gondii aspartyl protease ASP1 0.0108 0.1748 0.3275
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0692 0.0692
Onchocerca volvulus Huntingtin homolog 0.0139 0.2334 0.5088
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0027 0.0229 0.0527
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.0233
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.1823 0.3313
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0128 0.0279
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.1194 0.2213
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.3329 0.7258
Loa Loa (eye worm) hypothetical protein 0.0138 0.2312 0.504
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0479 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.0233
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.1194 0.2213
Loa Loa (eye worm) hypothetical protein 0.0052 0.0692 0.1507
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.1347 0.1071
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0103 0.1655 0.3001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.3329 0.3329
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0128 0.0128
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0047 0.0612 0.0612
Leishmania major cysteine peptidase A (CPA) 0.002 0.0101 0.0114
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0075 0.114 0.1112
Brugia malayi Pepsin A precursor 0.0052 0.0692 0.1507
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0229 0.05
Loa Loa (eye worm) hypothetical protein 0.0077 0.1167 0.2544
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0963 0.1414
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0128 0.0097
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0128 0.0279
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.0233
Loa Loa (eye worm) hypothetical protein 0.0022 0.0128 0.0279
Brugia malayi aspartic protease BmAsp-2, identical 0.0052 0.0692 0.1507
Onchocerca volvulus Cathepsin L homolog 0.002 0.0101 0.0221
Echinococcus granulosus acylamino acid releasing enzyme 0.0027 0.0229 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0101 0.0233
Brugia malayi nuclear hormone receptor 0.0022 0.0128 0.0279
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0377 0.0347
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0128 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0963 0.1414
Loa Loa (eye worm) hypothetical protein 0.0027 0.0229 0.05
Plasmodium falciparum plasmepsin VIII, putative 0.0052 0.0692 0.1249
Schistosoma mansoni cpg binding protein 0.0032 0.0327 0.0327
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0128 0.0279
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0231 0.4077 0.4268
Loa Loa (eye worm) hypothetical protein 0.0077 0.1167 0.2544
Loa Loa (eye worm) hypothetical protein 0.0077 0.1167 0.2544
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.0233
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0963 0.1716
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0075 0.114 0.2485
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0229 0.0351
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0047 0.0612 0.1063
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.1347 0.1071
Brugia malayi steroid hormone receptor 0.0022 0.0128 0.0279
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0229 0.05
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0963 0.1414
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0103 0.1655 0.3001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0128 0.0279
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0027 0.0229 0.0351
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0128 0.0128
Leishmania major hypothetical protein, conserved 0.0078 0.1194 0.2145
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1167 0.2682
Onchocerca volvulus 0.002 0.0101 0.0221
Brugia malayi Thioredoxin reductase 0.0038 0.0433 0.0943
Loa Loa (eye worm) hypothetical protein 0.0077 0.1167 0.2544
Onchocerca volvulus 0.0246 0.435 0.9483
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0128 0.0128
Brugia malayi PHD-finger family protein 0.0026 0.0206 0.0449
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0128 0.0128
Onchocerca volvulus 0.0029 0.0261 0.0568
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0128 0.0097
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0128 0.0279
Trypanosoma cruzi oligopeptidase b 0.0103 0.1655 0.3001
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.1167 0.086
Giardia lamblia Cathepsin B precursor 0.0047 0.0612 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.0233
Trypanosoma brucei oligopeptidase b 0.0103 0.1655 0.2747
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0625 0.0625
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.0233
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1167 0.2682
Plasmodium falciparum plasmepsin III 0.0052 0.0692 0.1249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0963 0.1414
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.1167 0.086
Loa Loa (eye worm) aspartyl protease 6 0.0052 0.0692 0.1507
Loa Loa (eye worm) hypothetical protein 0.0139 0.2334 0.5088
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1167 0.2682
Leishmania major cathepsin L-like protease 0.0066 0.0963 0.1716
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0128 0.0279
Loa Loa (eye worm) hypothetical protein 0.0078 0.1194 0.2603
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0128 0.0128
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0843 0.0814
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0108 0.1748 0.381
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0229 0.1258
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.3329 0.3329
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.052 0.0892
Onchocerca volvulus 0.002 0.0101 0.0221
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.038 0.038
Plasmodium vivax hypothetical protein, conserved 0.0077 0.1167 0.2161
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0101 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.0233
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0101 0.0101
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0229 0.1258
Schistosoma mansoni cpg binding protein 0.0029 0.0261 0.0261
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0963 0.1716
Trypanosoma brucei prolyl oligopeptidase, putative 0.0103 0.1655 0.2747
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0442 0.0413
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.0233
Schistosoma mansoni inositol monophosphatase 0.0112 0.1823 0.1823
Mycobacterium tuberculosis Conserved protein 0.0077 0.1167 0.086
Brugia malayi hypothetical protein 0.0052 0.0692 0.1507
Plasmodium vivax aspartyl proteinase, putative 0.0108 0.1748 0.3275
Plasmodium falciparum peptidase, putative 0.0027 0.0229 0.0363
Plasmodium falciparum plasmepsin VII 0.0052 0.0692 0.1249
Plasmodium vivax plasmepsin V, putative 0.0052 0.0692 0.1249
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0862 0.1527
Onchocerca volvulus Cathepsin L homolog 0.002 0.0101 0.0221
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0075 0.114 0.2485
Echinococcus multilocularis prolyl endopeptidase 0.0258 0.4587 0.457
Mycobacterium tuberculosis Conserved protein 0.0077 0.1167 0.086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0128 0.0279
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.0233
Schistosoma mansoni hypothetical protein 0.0017 0.004 0.004
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0075 0.114 0.262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.0233
Plasmodium vivax aspartyl proteinase, putative 0.0052 0.0692 0.1249
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0101 0.0556
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0101 0.0101
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0128 0.0128
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0075 0.114 0.114
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0075 0.114 0.2044
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0027 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0022 0.0128 0.0279
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0128 0.0097
Onchocerca volvulus 0.002 0.0101 0.0221
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0101 0.0221
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0258 0.4587 0.4587
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0128 0.0128
Brugia malayi Bromodomain containing protein 0.0075 0.1123 0.2448
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0103 0.1655 1
Loa Loa (eye worm) ctsf protein 0.002 0.0101 0.0221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0963 0.1414
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0101 0.0117
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0128 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0128 0.0279
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0128 0.0128
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0108 0.1748 0.1748
Toxoplasma gondii aspartyl protease 0.0052 0.0692 0.1249
Loa Loa (eye worm) hypothetical protein 0.0027 0.0229 0.05
Echinococcus multilocularis acylamino acid releasing enzyme 0.0027 0.0229 0.0199
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.5419 1
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0075 0.114 0.114
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0433 0.0753
Schistosoma mansoni inositol monophosphatase 0.0112 0.1823 0.1823
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0101 0.0114
Plasmodium falciparum thioredoxin reductase 0.0038 0.0433 0.0753
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0075 0.114 0.6254
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0963 0.1414
Echinococcus granulosus tissue type plasminogen activator 0.0017 0.004 0.004
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0128 0.0279
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1167 0.1167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.0233
Echinococcus granulosus cathepsin b 0.0138 0.2312 0.2312
Loa Loa (eye worm) hypothetical protein 0.0077 0.1167 0.2544
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.2312 0.2312
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0138 0.2312 0.4223
Loa Loa (eye worm) hypothetical protein 0.0069 0.1014 0.221
Brugia malayi nuclear receptor NHR-88 0.0022 0.0128 0.0279
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.1347 0.1071
Mycobacterium tuberculosis Probable peptidase 0.0103 0.1655 0.1431
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1167 0.2682
Echinococcus granulosus cpg binding protein 0.0032 0.0327 0.0327
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.0233
Brugia malayi Pre-SET motif family protein 0.0032 0.0313 0.0682
Loa Loa (eye worm) hypothetical protein 0.0052 0.0692 0.1507
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.3329 0.3329
Brugia malayi hypothetical protein 0.004 0.0479 0.1044
Loa Loa (eye worm) hypothetical protein 0.0139 0.2334 0.5088
Loa Loa (eye worm) hypothetical protein 0.0043 0.0531 0.1157
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.2312 0.2312
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0963 0.1414
Echinococcus multilocularis geminin 0.0546 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.379 0.8261
Loa Loa (eye worm) hypothetical protein 0.004 0.0465 0.1013
Plasmodium vivax vivapain-2 0.002 0.0101 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.0233
Echinococcus multilocularis cysteine protease 0.002 0.0101 0.0071
Loa Loa (eye worm) hypothetical protein 0.0022 0.0128 0.0279
Trypanosoma cruzi oligopeptidase b 0.0103 0.1655 0.3001
Loa Loa (eye worm) hypothetical protein 0.0108 0.1748 0.381
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0128 0.0128
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0229 0.05
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0692 0.0692
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0229 0.1258
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0103 0.1655 0.3139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0963 0.1414
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0128 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0128 0.0279
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.0233
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0101 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0229 0.0527
Brugia malayi Cathepsin L-like precursor 0.002 0.0101 0.0221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.0233
Mycobacterium tuberculosis Conserved protein 0.0077 0.1167 0.086
Loa Loa (eye worm) hypothetical protein 0.002 0.0101 0.0221
Loa Loa (eye worm) hypothetical protein 0.0022 0.0128 0.0279
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0027 0.0229 0.0199
Plasmodium falciparum plasmepsin X 0.0294 0.5253 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0112 0.1823 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0101 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0128 0.0279
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.3329 0.7258
Schistosoma mansoni coup transcription factor 0.0022 0.0128 0.0128
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0162 0.0162
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0027 0.0229 0.0351
Mycobacterium tuberculosis Probable reductase 0.0086 0.1347 0.1071
Brugia malayi cathepsin B-like cysteine proteinase 0.0138 0.2312 0.504
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0128 0.0279
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.1194 0.2145
Schistosoma mansoni cathepsin D (A01 family) 0.039 0.7071 0.7071
Echinococcus granulosus cathepsin l1 0.002 0.0101 0.0101
Onchocerca volvulus 0.002 0.0101 0.0221
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0692 0.0692
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0491 0.8971 1
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0229 0.1258
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0027 0.0229 0.0199
Schistosoma mansoni cpg binding protein 0.0032 0.0327 0.0327
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0101 0.0071
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0031 0.0031
Brugia malayi Cathepsin L-like precursor 0.002 0.0101 0.0221
Toxoplasma gondii hypothetical protein 0.0027 0.0229 0.0363
Echinococcus multilocularis cathepsin b 0.0138 0.2312 0.2288
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0128 0.0128
Brugia malayi Bromodomain containing protein 0.0037 0.042 0.0916
Leishmania major oligopeptidase b 0.0103 0.1655 0.3001
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0433 0.0943
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.1529 0.1284
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0258 0.4587 0.8453
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0112 0.1823 0.4218
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0101 0.0071
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0258 0.4587 0.4587
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0075 0.114 0.262
Brugia malayi follicle stimulating hormone receptor 0.0251 0.4452 0.9705
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0112 0.1823 0.3419
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0433 0.0729
Brugia malayi glutathione reductase 0.0038 0.0433 0.0943
Loa Loa (eye worm) cysteine protease 0.002 0.0101 0.0221
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0128 0.0128
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.1167 0.1807
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.0233
Leishmania major cathepsin L-like protease 0.0066 0.0963 0.1716
Loa Loa (eye worm) fibroinase 0.002 0.0101 0.0221
Trypanosoma cruzi prolyl endopeptidase 0.0258 0.4587 0.8453
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0229 0.05
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0963 0.1414
Entamoeba histolytica cysteine protease, putative 0.002 0.0101 0.0556
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.1167 0.086
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0692 0.0692
Plasmodium falciparum plasmepsin I 0.0108 0.1748 0.3275
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0128 0.0128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0128 0.0279
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.1167 0.1139
Schistosoma mansoni bromodomain containing protein 0.0063 0.0908 0.0908
Trichomonas vaginalis set domain proteins, putative 0.0246 0.435 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0047 0.0612 0.0738
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0128 0.0279
Brugia malayi hypothetical protein 0.0139 0.2334 0.5088
Echinococcus granulosus zinc finger protein 0.0021 0.0108 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.0233
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0229 0.0229
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0963 0.1716
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0128 0.0279
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.1347 0.3699
Mycobacterium ulcerans hypothetical protein 0.0159 0.2721 1
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0108 0.1748 0.4017
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0075 0.114 0.2044
Schistosoma mansoni zinc finger protein 0.0021 0.0108 0.0108
Plasmodium vivax plasmepsin IV, putative 0.0108 0.1748 0.3275
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.1167 0.086
Onchocerca volvulus 0.0032 0.0313 0.0682
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0625 0.0596
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.1347 0.1071
Brugia malayi Inositol-1 0.0112 0.1823 0.3973
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0027 0.0229 0.0351
Entamoeba histolytica hypothetical protein 0.004 0.0479 0.2627
Plasmodium falciparum plasmepsin IX 0.0294 0.5253 1
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0027 0.0229 0.0229
Brugia malayi prolyl oligopeptidase family protein 0.0258 0.4587 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0108 0.1748 0.1722
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0313 0.0283
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.1823 0.3313
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0313 0.0523
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.1194 0.2213
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0027 0.0229 0.05
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.1347 0.1071
Toxoplasma gondii cathepsin B 0.0047 0.0612 0.1097
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0103 0.1655 0.2747
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0108 0.1748 0.3275
Brugia malayi beta-lactamase 0.0077 0.1167 0.2544
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0075 0.114 0.2109
Schistosoma mansoni hypothetical protein 0.0035 0.038 0.038
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.1167 0.2544
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0075 0.114 0.2485
Brugia malayi hypothetical protein 0.0052 0.0692 0.1507
Schistosoma mansoni memapsin-2 (A01 family) 0.0052 0.0692 0.0692
Brugia malayi Kringle domain containing protein 0.0017 0.004 0.0088
Plasmodium vivax aspartyl protease, putative 0.0294 0.5253 1
Onchocerca volvulus 0.0077 0.1167 0.2544
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.0233
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0101 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0128 0.0279
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0692 0.0692
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0128 0.0279
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0101 0.0233
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0047 0.0612 0.1407
Schistosoma mansoni cathepsin D (A01 family) 0.039 0.7071 0.7071
Echinococcus multilocularis zinc finger protein 0.0021 0.0108 0.0077
Echinococcus granulosus inositol monophosphatase 1 0.0112 0.1823 0.1823
Brugia malayi Cathepsin L-like precursor 0.002 0.0101 0.0221
Brugia malayi CXXC zinc finger family protein 0.0029 0.0261 0.0568
Loa Loa (eye worm) hypothetical protein 0.0077 0.1167 0.2544
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.1167 0.086
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0128 0.0128
Onchocerca volvulus 0.0017 0.004 0.0088
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0128 0.0128
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0128 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1167 0.2094
Leishmania major cathepsin L-like protease 0.002 0.0101 0.0114
Echinococcus multilocularis cathepsin b 0.0138 0.2312 0.2288
Toxoplasma gondii ABC1 family protein 0.0077 0.1167 0.2161
Echinococcus granulosus cathepsin b 0.0138 0.2312 0.2312
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0625 0.0625
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.1529 0.7425
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0479 0.0479
Loa Loa (eye worm) hypothetical protein 0.0258 0.4587 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0101 0.0101
Brugia malayi Eukaryotic aspartyl protease family protein 0.0052 0.0692 0.1507
Loa Loa (eye worm) hypothetical protein 0.0022 0.0128 0.0279
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1167 0.2094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0128 0.0279
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0313 0.0313
Schistosoma mansoni hypothetical protein 0.0546 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0128 0.0279
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0128 0.0128
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0075 0.114 0.2044
Schistosoma mansoni hypothetical protein 0.002 0.0097 0.0097
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0112 0.1823 0.419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0128 0.0279
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.2417 0.4418
Onchocerca volvulus 0.0052 0.0692 0.1507
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.5419 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.052 0.0892
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0261 0.0568
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.4452 0.9705
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.0233
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.1194 0.1859
Leishmania major cathepsin L-like protease 0.002 0.0101 0.0114
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0713 0.1251
Plasmodium vivax aspartyl protease, putative 0.0052 0.0692 0.1249
Entamoeba histolytica hypothetical protein 0.004 0.0479 0.2627
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0963 0.1716
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0101 0.0221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.3329 0.3309
Trichomonas vaginalis inositol monophosphatase, putative 0.0112 0.1823 0.419
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.1167 0.1167
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0313 0.0313
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.089 0.089
Brugia malayi hypothetical protein 0.0051 0.0671 0.1463
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0138 0.2312 0.2312
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0052 0.0692 0.1249
Brugia malayi beta-lactamase family protein 0.0077 0.1167 0.2544
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0101 0.0221
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0162 0.0132
Loa Loa (eye worm) TK/ROR protein kinase 0.0017 0.004 0.0088
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0075 0.114 0.2485
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.1529 0.1284
Brugia malayi hypothetical protein 0.0078 0.1194 0.2603
Loa Loa (eye worm) glutathione reductase 0.0038 0.0433 0.0943
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0075 0.114 0.2109
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0097 0.021
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0843 0.0843
Plasmodium falciparum plasmepsin V 0.0052 0.0692 0.1249
Plasmodium vivax glutathione reductase, putative 0.0038 0.0433 0.0753
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.3329 0.3329
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0128 0.0097
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.1167 0.2544
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.3329 0.3329
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0103 0.1655 0.1431
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0027 0.0229 0.0527
Onchocerca volvulus 0.002 0.0101 0.0221
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0108 0.1748 0.1748
Toxoplasma gondii prolyl endopeptidase 0.0258 0.4587 0.8723
Leishmania major mitochondrial DNA polymerase beta 0.0303 0.5419 1
Plasmodium falciparum plasmepsin II 0.0108 0.1748 0.3275
Loa Loa (eye worm) inositol-1 0.0112 0.1823 0.3973
Trichomonas vaginalis esterase, putative 0.0077 0.1167 0.2682
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0128 0.0128
Brugia malayi aspartic protease BmAsp-1, identical 0.0052 0.0692 0.1507
Toxoplasma gondii aspartyl protease ASP3 0.0294 0.5253 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0052 0.0692 0.1507
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0229 0.1258
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0075 0.114 0.1754
Loa Loa (eye worm) hypothetical protein 0.0037 0.0421 0.0918
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0128 0.0128
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0479 0.0449
Loa Loa (eye worm) hypothetical protein 0.0048 0.0625 0.1362
Schistosoma mansoni hypothetical protein 0.0546 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0128 0.0279
Onchocerca volvulus Huntingtin homolog 0.0139 0.2334 0.5088
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0128 0.0279
Brugia malayi Cathepsin L-like precursor 0.002 0.0101 0.0221
Echinococcus multilocularis inositol monophosphatase 1 0.0112 0.1823 0.1797
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0103 0.1655 0.3001
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.1194 0.2145
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0128 0.0279
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0229 0.0363
Trypanosoma brucei trypanothione reductase 0.0038 0.0433 0.0392
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0229 0.05
Plasmodium vivax vivapain-2 0.002 0.0101 0.0117
Loa Loa (eye worm) cathepsin B 0.0047 0.0612 0.1335
Trypanosoma brucei prolyl endopeptidase 0.0258 0.4587 0.8397
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.01 0.1602 0.8921
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.2417 0.4418
Giardia lamblia Cathepsin B precursor 0.0047 0.0612 1
Leishmania major cathepsin L-like protease 0.002 0.0101 0.0114
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0031 0.0031
Plasmodium vivax aspartyl protease, putative 0.0294 0.5253 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0128 0.0279
Brugia malayi ecdysteroid receptor 0.0022 0.0128 0.0279
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0128 0.0097
Entamoeba histolytica hypothetical protein 0.004 0.0479 0.2627
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0442 0.0442
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0027 0.0229 0.0363
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0229 0.1258
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0031 0.0031
Plasmodium falciparum glutathione reductase 0.0038 0.0433 0.0753
Onchocerca volvulus 0.0052 0.0692 0.1507
Brugia malayi Protein kinase domain containing protein 0.0017 0.004 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0963 0.1414
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0128 0.0279
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0128 0.0097
Loa Loa (eye worm) hypothetical protein 0.0022 0.0128 0.0279
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0112 0.1823 0.5
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0042 0.0092
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.1194 0.2213
Plasmodium falciparum plasmepsin VI 0.0108 0.1748 0.3275
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.1529 0.1284
Plasmodium falciparum plasmepsin IV 0.0108 0.1748 0.3275
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.2721 0.268
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0229 0.05
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0128 0.0279
Brugia malayi Pre-SET motif family protein 0.0216 0.379 0.8261
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0101 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.0233
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0692 0.0692

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Reversal of haloperidol-induced hypolocomotion in mouse at 30 mg/kg, ip ChEMBL. 18411049
Activity (functional) 0 Reversal of haloperidol-induced hypolocomotion in mouse at 30 mg/kg, ip ChEMBL. 18411049
Ki (binding) = 1 nM Binding affinity at human adenosine A2A receptor ChEMBL. 18411049
Ki (binding) = 1 nM Binding affinity at human adenosine A2A receptor ChEMBL. 18411049
Ki (binding) = 1.1 nM Binding affinity to human adenosine A2A receptor ChEMBL. 18637670
Ki (functional) = 1.1 nM Inhibition of human recombinant adenosine receptor A2a ChEMBL. 24164628
Ki (binding) = 17 nM Binding affinity at human adenosine A1 receptor ChEMBL. 18411049
Ki (binding) = 17 nM Binding affinity at human adenosine A1 receptor ChEMBL. 18411049
Ki (binding) = 17 nM Inhibition of human recombinant adenosine A1 receptor ChEMBL. 24164628
Ki (binding) = 112 nM Inhibition of human recombinant adenosine receptor A2b ChEMBL. 24164628
Ki (binding) = 1472 nM Inhibition of human recombinant adenosine A3 receptor ChEMBL. 24164628

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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