Detailed information for compound 541484

Basic information

Technical information
  • TDR Targets ID: 541484
  • Name: 9-(3,4-dimethoxyphenyl)-6-[2-(trifluoromethyl )phenyl]-5,6,8,9,10,11-hexahydrobenzo[c][1,5] benzodiazepin-7-one
  • MW: 494.505 | Formula: C28H25F3N2O3
  • H donors: 2 H acceptors: 1 LogP: 5.63 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC)C1CC(=O)C2=C(C1)Nc1ccccc1NC2c1ccccc1C(F)(F)F
  • InChi: 1S/C28H25F3N2O3/c1-35-24-12-11-16(15-25(24)36-2)17-13-22-26(23(34)14-17)27(33-21-10-6-5-9-20(21)32-22)18-7-3-4-8-19(18)28(29,30)31/h3-12,15,17,27,32-33H,13-14H2,1-2H3
  • InChiKey: XARIKKKVMUHCHJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • A2333/0098431
  • ChemDiv1_006128
  • MixCom6_002539
  • BIM-0047540.P001
  • CBMicro_047595

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0564 0.1684
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.0204 0.0271
Trichomonas vaginalis helicase, putative 0.0028 0.0064 0.0522
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0039 0.0153
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0308 0.2654
Loa Loa (eye worm) hypothetical protein 0.0216 0.0851 0.2115
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0087 0.0308 0.1202
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0086 0.0321
Brugia malayi Glycosyl hydrolases family 31 protein 0.0087 0.0308 0.092
Brugia malayi RNA, U transporter 1 0.0259 0.1031 0.3077
Leishmania major hypothetical protein, conserved 0.0017 0.0017 0.0117
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0067 0.0086
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0141 0.0138
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.008 0.0454
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.0362 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.0204 0.0609
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.02
Onchocerca volvulus Huntingtin homolog 0.0147 0.0559 0.1668
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0067 0.0226 0.1887
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0091 0.0763
Toxoplasma gondii ABC1 family protein 0.0035 0.0091 0.0355
Toxoplasma gondii HEAT repeat-containing protein 0.0091 0.0327 0.1275
Schistosoma mansoni hypothetical protein 0.0047 0.0141 0.0186
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0091 0.0342
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.0204 0.0201
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0144 0.0549
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0032 0.008 0.0651
Mycobacterium ulcerans hypothetical protein 0.0048 0.0144 0.0549
Echinococcus granulosus bloom syndrome protein 0.0054 0.0173 0.023
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.0204 0.0609
Echinococcus granulosus GPCR family 2 0.0047 0.0141 0.0186
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0091 0.0763
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.01 0.0362 0.0359
Brugia malayi nuclear receptor NHR-88 0.0062 0.0204 0.0609
Onchocerca volvulus 0.0014 0.0004 0.0011
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0204 0.0271
Schistosoma mansoni hypothetical protein 0.1777 0.7392 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0064 0.0522
Mycobacterium leprae Probable lipase LipE 0.0035 0.0091 0.0342
Echinococcus granulosus nuclear receptor co repressor related ncor 0.027 0.1075 0.145
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0067 0.0167
Loa Loa (eye worm) apoptosis regulator protein 0.01 0.0362 0.09
Schistosoma mansoni importin beta-1 0.0091 0.0327 0.0438
Schistosoma mansoni myst-related protein 0.0015 0.0007 0.0004
Echinococcus multilocularis muscleblind protein 0.0658 0.2701 0.2699
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0204 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0064 0.0522
Echinococcus granulosus importin 5 0.0017 0.0017 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0091 0.0763
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0113 0.0955
Schistosoma mansoni hypothetical protein 0.0089 0.032 0.0428
Trichomonas vaginalis maltase-glucoamylase, putative 0.0032 0.008 0.0669
Loa Loa (eye worm) hypothetical protein 0.0166 0.0639 0.1589
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0064 0.0522
Plasmodium falciparum importin beta, putative 0.0091 0.0327 1
Onchocerca volvulus 0.0029 0.0067 0.0201
Echinococcus granulosus muscleblind protein 0.0658 0.2701 0.3651
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0119 0.0443 0.2598
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0144 0.0549
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0144 0.0549
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0094 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0067 0.0064
Plasmodium vivax importin-beta 2, putative 0.0091 0.0327 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0091 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0064 0.0522
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0125 0.0164
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0198 0.0774 0.1043
Entamoeba histolytica hypothetical protein 0.0035 0.0092 0.0522
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0004 0.0014
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.0204 0.0271
Brugia malayi Muscleblind-like protein 0.0658 0.2701 0.8059
Entamoeba histolytica Ran family GTPase 0.0067 0.0226 0.1316
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0109 0.0897
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0091 0.0342
Loa Loa (eye worm) hypothetical protein 0.0062 0.0204 0.0507
Schistosoma mansoni patched 1 0.0093 0.0334 0.0447
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0531 0.4472
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.0551 0.1644
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0119 0.098
Schistosoma mansoni hypothetical protein 0.0089 0.032 0.0428
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0067 0.0064
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0144 0.0549
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0064 0.0522
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0009 0.0044
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0973 0.4023 1
Loa Loa (eye worm) acetyltransferase 0.0146 0.0556 0.1381
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0157 0.1303
Echinococcus granulosus sterol regulatory element binding protein 0.0093 0.0334 0.0447
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0091 0.0227
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0637 0.5512
Onchocerca volvulus Huntingtin homolog 0.0147 0.0559 0.1668
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.1183 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0067 0.0226 0.0562
Brugia malayi ecdysone receptor 0.0029 0.0067 0.0201
Giardia lamblia DNA repair protein RAD52 0.0418 0.1696 1
Loa Loa (eye worm) hypothetical protein 0.0299 0.1198 0.2977
Brugia malayi Steroid receptor seven-up type 2 0.0062 0.0204 0.0609
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0091 0.0763
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0074 0.0255 0.2188
Onchocerca volvulus 0.0062 0.0204 0.0609
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0531 0.4472
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0556 0.0552
Brugia malayi Flap endonuclease-1 0.0031 0.0076 0.0227
Brugia malayi beta-lactamase 0.0035 0.0091 0.0272
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0004 0.0009
Loa Loa (eye worm) oxidoreductase 0.0014 0.0004 0.0009
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0637 0.1899
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0067 0.0167
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0048 0.0146 0.4455
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0039 0.0036
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0067 0.0538
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0087 0.0308 0.2654
Echinococcus multilocularis thyroid hormone receptor alpha 0.0062 0.0204 0.0201
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0076 0.0297
Loa Loa (eye worm) hypothetical protein 0.0062 0.0204 0.0507
Echinococcus granulosus Niemann Pick C1 protein 0.0216 0.0851 0.1147
Schistosoma mansoni flap endonuclease-1 0.0028 0.0064 0.0081
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1152 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.0204 0.0507
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0017 0.0068
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0039 0.0107 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0064 0.0522
Mycobacterium ulcerans beta-lactamase 0.0035 0.0091 0.0342
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0092 0.0088
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0004 0.0014
Onchocerca volvulus 0.0125 0.0468 0.1396
Trichomonas vaginalis rotamase, putative 0.0039 0.0109 0.0921
Brugia malayi conserved hypotetical protein 0.0029 0.0067 0.0201
Brugia malayi hypothetical protein 0.0033 0.0082 0.0244
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0091 0.0342
Schistosoma mansoni ran 0.0067 0.0226 0.0301
Trichomonas vaginalis DNA helicase recq1, putative 0.0054 0.0173 0.1479
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0637 0.5512
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0004 0.0011
Echinococcus multilocularis GPCR, family 2 0.0047 0.0141 0.0138
Loa Loa (eye worm) hypothetical protein 0.0022 0.0039 0.0098
Schistosoma mansoni alpha-glucosidase 0.0336 0.1354 0.1828
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0091 0.0342
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0036 0.0098 0.0381
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.0999 0.2981
Echinococcus multilocularis bloom syndrome protein 0.0054 0.0173 0.017
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0167
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0637 0.5512
Trichomonas vaginalis rotamase, putative 0.004 0.0113 0.0955
Schistosoma mansoni nuclear receptor 0.0029 0.0067 0.0086
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0119 0.098
Mycobacterium tuberculosis Conserved protein 0.0035 0.0091 0.0342
Trichomonas vaginalis hypothetical protein 0.0017 0.0017 0.012
Loa Loa (eye worm) hypothetical protein 0.0048 0.0144 0.0359
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0227
Entamoeba histolytica hypothetical protein 0.0015 0.0007 0.0019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0167
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0092 0.012
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0308 0.2654
Echinococcus multilocularis protein patched 0.0093 0.0334 0.033
Onchocerca volvulus 0.0014 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0227
Onchocerca volvulus 0.0014 0.0004 0.0011
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1152 0.6786
Loa Loa (eye worm) hypothetical protein 0.0114 0.0421 0.1047
Echinococcus granulosus microtubule associated protein 2 0.1655 0.6879 0.9306
Echinococcus multilocularis geminin 0.0502 0.205 0.2047
Schistosoma mansoni DNA helicase recq1 0.0022 0.0039 0.0048
Leishmania major alpha glucosidase II subunit, putative 0.0087 0.0308 0.2583
Echinococcus granulosus mixed lineage leukemia protein mll 0.0031 0.0075 0.0097
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0091 0.0763
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0144 0.0831
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0087 0.0308 0.2654
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0144 0.043
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0368 0.1099
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0009
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0125 0.0486
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0141 0.0186
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0674 0.5836
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0535 0.2074
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0204 0.0609
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0039 0.0048
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0539 0.0724
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0062 0.0204 0.0201
Brugia malayi Niemann-Pick C1 protein precursor 0.0216 0.0851 0.2539
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.008 0.0669
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0064 0.0522
Entamoeba histolytica recQ family helicase, putative 0.0029 0.0067 0.0375
Entamoeba histolytica hypothetical protein 0.0035 0.0092 0.0522
Trypanosoma brucei importin beta-1 subunit, putative 0.0091 0.0327 0.2742
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0067 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.0204 0.0609
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0004 0.0011
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0004 0.0109
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0067 0.0201
Onchocerca volvulus 0.0048 0.0144 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0064 0.0522
Loa Loa (eye worm) kap beta 3 protein 0.0017 0.0017 0.0043
Loa Loa (eye worm) hypothetical protein 0.0047 0.0141 0.0351
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0039 0.1203
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0227
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0637 0.5512
Loa Loa (eye worm) histone methyltransferase 0.0039 0.0107 0.0266
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0204
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0551 0.0741
Mycobacterium ulcerans hypothetical protein 0.0035 0.0091 0.0342
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0067 0.0064
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.0999 0.2483
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0039 0.0048
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0091 0.0342
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.0204 0.0271
Loa Loa (eye worm) beta-lactamase 0.0035 0.0091 0.0227
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0067 0.0226 0.1887
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0204 0.0609
Toxoplasma gondii hypothetical protein 0.0048 0.0145 0.0565
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0076 0.0616
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.0204 0.0609
Leishmania major importin beta-1 subunit, putative 0.0074 0.0255 0.213
Echinococcus granulosus geminin 0.0502 0.205 0.277
Echinococcus granulosus Protein patched homolog 1 0.0093 0.0334 0.0447
Loa Loa (eye worm) importin-beta domain-containing protein 0.0017 0.0017 0.0043
Brugia malayi Glycosyl hydrolases family 31 protein 0.0032 0.008 0.024
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0233
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.01 0.0362 0.108
Schistosoma mansoni apoptosis regulator bax 0.01 0.0362 0.0485
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0167
Leishmania major glycosyl hydrolase-like protein 0.0032 0.008 0.0651
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0167
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.0308 0.2583
Entamoeba histolytica hypothetical protein 0.0074 0.0255 0.1485
Brugia malayi steroid hormone receptor 0.0062 0.0204 0.0609
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0391 0.1582 0.3933
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0067 0.0226 0.0223
Echinococcus granulosus lysosomal alpha glucosidase 0.0391 0.1582 0.2137
Trypanosoma cruzi importin beta-1 subunit, putative 0.0074 0.0255 0.213
Echinococcus multilocularis lysosomal alpha glucosidase 0.0391 0.1582 0.1579
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0086 0.0321
Echinococcus multilocularis snurportin 1 0.0973 0.4023 0.4021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0204
Schistosoma mansoni DNA helicase recq5 0.0022 0.0039 0.0048
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0999 0.8668
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0556 0.1658
Brugia malayi nuclear receptor NHR-67 0.0029 0.0067 0.0201
Trichomonas vaginalis sucrase-isomaltase, putative 0.0087 0.0308 0.2654
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0067 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0637 0.5512
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0144 0.0549
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0999 0.8668
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0204 0.0609
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0067 0.0086
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0067 0.0201
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0625 0.2564 1
Schistosoma mansoni rotamase 0.004 0.0113 0.0149
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.01 0.0362 0.0485
Trypanosoma brucei glucosidase, putative 0.0087 0.0308 0.2583
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0204 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0064 0.0522
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.0204 0.0201
Loa Loa (eye worm) hypothetical protein 0.0101 0.0368 0.0916
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0074 0.0255 0.2188
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0067 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.0204 0.0507
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0674 0.5836
Echinococcus granulosus expressed conserved protein 0.0203 0.0796 0.1073
Echinococcus multilocularis transportin 1 0.0017 0.0017 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1152 1
Schistosoma mansoni hypothetical protein 0.01 0.0362 0.0485
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1152 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0535 0.2074
Schistosoma mansoni zinc finger protein 0.0029 0.0067 0.0086
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0067 0.0201
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0064 0.0522
Schistosoma mansoni hypothetical protein 0.0502 0.205 0.277
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0064 0.0522
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0031 0.0075 0.0071
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0265 0.1054 0.1422
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0227
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0004 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0082 0.0106
Echinococcus multilocularis cpg binding protein 0.0132 0.0498 0.0494
Echinococcus granulosus cpg binding protein 0.0132 0.0498 0.0669
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0067 0.0086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1152 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0113 0.0338
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.002 0.0022
Trichomonas vaginalis ran, putative 0.0067 0.0226 0.1939
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.0204 0.0507
Onchocerca volvulus 0.0035 0.0091 0.0272
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0233
Schistosoma mansoni hypothetical protein 0.0035 0.0092 0.012
Schistosoma mansoni importin-beta 2 0.0017 0.0017 0.0019
Echinococcus granulosus dnaJ subfamily B 0.1777 0.7392 1
Echinococcus multilocularis expressed protein 0.004 0.0113 0.011
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0039 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.0204 0.0609
Loa Loa (eye worm) hypothetical protein 0.0062 0.0204 0.0507
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.1152 0.6717
Trypanosoma brucei glycosyl hydrolase-like protein 0.0032 0.008 0.0651
Loa Loa (eye worm) DR-78 0.0029 0.0067 0.0167
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0204 0.0271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1152 1
Echinococcus multilocularis importin subunit beta 1 0.0091 0.0327 0.0324
Schistosoma mansoni hypothetical protein 0.0345 0.1389 0.1875
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0067 0.0064
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0032 0.008 0.0651
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1183 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0216 0.0851 0.5007
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0087 0.0308 0.1801
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.0204 0.0507
Schistosoma mansoni hypothetical protein 0.0101 0.0368 0.0494
Schistosoma mansoni cpg binding protein 0.0132 0.0498 0.0669
Trypanosoma brucei importin beta-1 subunit, putative 0.0091 0.0327 0.2742
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0119 0.098
Brugia malayi CHE-14 protein 0.0093 0.0334 0.0996
Brugia malayi hypothetical protein 0.0029 0.0067 0.0201
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0878 0.3416
Loa Loa (eye worm) hypothetical protein 0.0062 0.0204 0.0507
Loa Loa (eye worm) hypothetical protein 0.0293 0.1172 0.2913
Brugia malayi ecdysteroid receptor 0.0062 0.0204 0.0609
Entamoeba histolytica hypothetical protein 0.0035 0.0092 0.0522
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0017 0.0068
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0125 0.1054
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0109 0.0897
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0167
Entamoeba histolytica hypothetical protein 0.0035 0.0092 0.0522
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.0204 0.0271
Loa Loa (eye worm) hypothetical protein 0.0091 0.0327 0.0813
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0082 0.0106
Schistosoma mansoni hypothetical protein 0.0973 0.4023 0.544
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0067 0.0201
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0091 0.0743
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0144 0.0831
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0086 0.0321
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0167
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0076 0.0189
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0004 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0144 0.1193
Echinococcus granulosus GTP binding nuclear protein Ran 0.0067 0.0226 0.0301
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0087 0.0308 0.0766
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0113 0.0282
Onchocerca volvulus 0.0014 0.0004 0.0011
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0004 0.0011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.0204 0.0271
Trichomonas vaginalis DNA helicase recq, putative 0.0054 0.0173 0.1479
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0227
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0076 0.0616
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0091 0.0119
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0017 0.0017 0.0117
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0141 0.0421
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0094 0.0353
Entamoeba histolytica hypothetical protein 0.0119 0.0443 0.2598
Entamoeba histolytica HEAT repeat domain containing protein 0.0017 0.0017 0.0081
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.027 0.1075 0.1072
Onchocerca volvulus 0.0813 0.3352 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0597 0.2319
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.008 0.0669
Onchocerca volvulus 0.0035 0.0091 0.0272
Brugia malayi CXXC zinc finger family protein 0.0125 0.0468 0.1396
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.0204 0.0609
Brugia malayi photoreceptor-specific nuclear receptor 0.0293 0.1172 0.3496
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0075 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0091 0.0743
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0144 0.0549
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.0204 0.0271
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.008 0.0669
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0119 0.098
Mycobacterium ulcerans hypothetical protein 0.0156 0.0597 0.2319
Onchocerca volvulus 0.0226 0.0892 0.2661
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0167
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0004 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1152 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0125 0.0468 0.1163
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.008 0.0669
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0064 0.0522
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0141 0.0351
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1183 1
Echinococcus granulosus X box binding protein 1 0.0345 0.1389 0.1875
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0067 0.0167
Loa Loa (eye worm) hypothetical protein 0.0062 0.0204 0.0507
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0204 0.0609
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0064 0.0522
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0308 0.2654
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0004 0.0011
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0067 0.0064
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0091 0.0342
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0418 0.1696 1
Brugia malayi hypothetical protein 0.0813 0.3352 1
Brugia malayi nuclear receptor RXR 0.0029 0.0067 0.0201
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.008 0.0669
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0082 0.0244
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.0204 0.0609
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0067 0.0538
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0204
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0227
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0144 0.043
Echinococcus granulosus expressed protein 0.004 0.0113 0.0149
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0109 0.0897
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0067 0.0226 0.1887
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0233
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0125 0.0486
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0637 0.5512
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0094 0.2871
Schistosoma mansoni alpha-glucosidase 0.0336 0.1354 0.1828
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0551 0.0741
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0204 0.0271
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0167
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0067 0.0201
Echinococcus multilocularis Niemann Pick C1 protein 0.0309 0.124 0.1237
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0204 0.0271
Schistosoma mansoni hypothetical protein 0.0089 0.032 0.0428
Schistosoma mansoni cpg binding protein 0.0125 0.0468 0.0629
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0067 0.0553
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.0204 0.0609
Leishmania major GTP-binding protein, putative 0.0067 0.0226 0.1887
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0144 0.0549
Loa Loa (eye worm) hypothetical protein 0.0658 0.2701 0.6715
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0125 0.1054
Loa Loa (eye worm) hypothetical protein 0.0147 0.0559 0.139
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0198 0.0774 0.0771
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0091 0.0088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.0204 0.0507
Brugia malayi nuclear receptor RXR 0.0033 0.0082 0.0244
Trichomonas vaginalis maltase-glucoamylase, putative 0.0087 0.0308 0.2654
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0144 0.0549
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0091 0.0342
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.0204 0.0271
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0308 0.2654
Echinococcus multilocularis Niemann Pick C1 protein 0.0216 0.0851 0.0848
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1152 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.022 0.0865 0.1166
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0039 0.0153
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0039 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0233
Schistosoma mansoni microtubule-associated protein tau 0.1655 0.6879 0.9306
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0067 0.0086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.1152 1
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.0204 0.0201
Leishmania major hypothetical protein, conserved 0.0035 0.0091 0.0743
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0999 0.8668
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0076 0.0633
Brugia malayi tailless protein 0.0029 0.0067 0.0201
Brugia malayi beta-lactamase family protein 0.0035 0.0091 0.0272
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0144 0.043
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0067 0.0226 0.6916
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0535 0.2074
Echinococcus multilocularis sterol regulatory element binding protein 0.0093 0.0334 0.033
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.008 0.0669
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.0204 0.0507
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.0204 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.0204 0.0609
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0144 0.0549
Brugia malayi F/Y-rich N-terminus family protein 0.0038 0.0105 0.0313
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0204 0.0271
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.0204 0.0201
Toxoplasma gondii histone lysine methyltransferase SET1 0.024 0.0951 0.3707
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0091 0.0272
Schistosoma mansoni hypothetical protein 0.0047 0.0141 0.0186
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.0551 0.137
Plasmodium falciparum transportin 0.0017 0.0017 0.0529
Loa Loa (eye worm) hypothetical protein 0.0062 0.0204 0.0507
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0067 0.0538
Loa Loa (eye worm) hypothetical protein 0.0147 0.0559 0.139
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0999 0.8668
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.008 0.0669
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.0204 0.0271
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0204 0.0271
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.0625 0.2564 1
Schistosoma mansoni hypothetical protein 0.01 0.0362 0.0485
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0094 0.2871
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0067 0.0226 0.0675
Schistosoma mansoni hypothetical protein 0.0502 0.205 0.277
Echinococcus granulosus Niemann Pick C1 protein 0.0309 0.124 0.1673
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0564 0.1403
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0999 0.8668
Brugia malayi Importin beta-1 subunit 0.0091 0.0327 0.0976
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0144 0.1193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0551 0.0741
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0334 0.2876
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0067 0.0064
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0204 0.0201
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0109 0.0897
Plasmodium falciparum zinc finger protein, putative 0.0015 0.0007 0.0207
Schistosoma mansoni hypothetical protein 0.01 0.0362 0.0485
Onchocerca volvulus 0.0029 0.0067 0.0201
Loa Loa (eye worm) hypothetical protein 0.0658 0.2701 0.6715
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0167
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0076 0.0073
Echinococcus multilocularis protein dispatched 1 0.0106 0.0389 0.0385
Trichomonas vaginalis esterase, putative 0.0035 0.0091 0.0763
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0067 0.0226 0.1128
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0144 0.0549
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0299 0.1198 0.3573
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0308 0.2654
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.1183 1
Echinococcus multilocularis expressed conserved protein 0.0203 0.0796 0.0793
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.1152 0.6786
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0064 0.0522
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0144 0.1193
Brugia malayi hypothetical protein 0.0147 0.0559 0.1668
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0039 0.0117
Echinococcus multilocularis lysosomal alpha glucosidase 0.0391 0.1582 0.1579
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0204
Brugia malayi hypothetical protein 0.0035 0.0092 0.0274
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0091 0.0342
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0082 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0009 0.0044
Schistosoma mansoni hypothetical protein 0.0047 0.0141 0.0186
Echinococcus granulosus FTZ F1 alpha 0.0062 0.0204 0.0271
Echinococcus multilocularis importin 5 0.0017 0.0017 0.0014
Brugia malayi Bloom's syndrome protein homolog 0.0054 0.0173 0.0517
Echinococcus granulosus flap endonuclease 1 0.0031 0.0076 0.0098
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.0204 0.0271
Echinococcus granulosus transportin 1 0.0017 0.0017 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.0204 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0064 0.0522
Plasmodium vivax transportin, putative 0.0017 0.0017 0.0529
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0076 0.2331
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0093 0.0334 0.083
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0004 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0999 0.8668
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0092 0.012
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.011 0.3354
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.0204 0.0271
Loa Loa (eye worm) hypothetical protein 0.0813 0.3352 0.8332
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0037 0.0099 0.3042
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.0204 0.0609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0551 0.0741
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0086 0.0321
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0556 0.0747
Brugia malayi nuclear hormone receptor 0.0029 0.0067 0.0201
Plasmodium falciparum flap endonuclease 1 0.0031 0.0076 0.2331
Schistosoma mansoni blooms syndrome DNA helicase 0.0043 0.0125 0.0165
Echinococcus granulosus neutral alpha glucosidase AB 0.0087 0.0308 0.0413
Brugia malayi hypothetical protein 0.0029 0.0067 0.0201
Loa Loa (eye worm) RecQ helicase 0.0054 0.0173 0.0431
Brugia malayi Glycosyl hydrolases family 31 protein 0.0391 0.1582 0.472
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0167
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0109 0.0426
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0091 0.2788
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0004 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0637 0.5512
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0076 0.0223
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0067 0.0201
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0087 0.0308 0.1801
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0082 0.0204
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0167
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0094 0.0353
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.011 0.0425
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.0204 0.0271
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.011 0.0627
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0125 0.3811
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0067 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0064 0.0522
Echinococcus granulosus importin subunit beta 1 0.0091 0.0327 0.0438
Brugia malayi hypothetical protein 0.0033 0.0082 0.0244
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.0308 0.2583
Schistosoma mansoni hypothetical protein 0.0047 0.0141 0.0186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.0204 0.0507
Loa Loa (eye worm) hypothetical protein 0.0048 0.0144 0.0359
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0091 0.0119
Brugia malayi nuclear receptor NHR-88 0.0029 0.0067 0.0201
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0067 0.0226 0.0882
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0551 0.0548
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0067 0.0086
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0039 0.0098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0064 0.0522
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0625 0.2564 1
Schistosoma mansoni alpha glucosidase 0.0087 0.0308 0.0413
Echinococcus multilocularis neutral alpha glucosidase AB 0.0087 0.0308 0.0305
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0167
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.0204 0.0201
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0091 0.0342
Loa Loa (eye worm) hypothetical protein 0.0062 0.0204 0.0507
Schistosoma mansoni coup transcription factor 0.0062 0.0204 0.0271
Brugia malayi kap beta 3 protein 0.0017 0.0017 0.0052
Loa Loa (eye worm) hypothetical protein 0.0093 0.0334 0.083
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0109 0.0625
Mycobacterium tuberculosis Conserved protein 0.0035 0.0091 0.0342
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0067 0.0086
Echinococcus multilocularis muscleblind protein 1 0.0658 0.2701 0.2699
Echinococcus granulosus translational activator gcn1 0.0017 0.0017 0.0019
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0075 0.0071
Echinococcus multilocularis X box binding protein 1 0.0345 0.1389 0.1386
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.0204 0.0271
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0167
Echinococcus multilocularis dnaJ subfamily B 0.1777 0.7392 0.7391
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0144 0.0549
Schistosoma mansoni ran 0.0067 0.0226 0.0301
Onchocerca volvulus 0.0035 0.0091 0.0272
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0233
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0144 0.0831
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0551 0.0741
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0075 0.0097
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0091 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0204 0.0609
Mycobacterium ulcerans lipase LipD 0.0035 0.0091 0.0342
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0017 0.0017 0.0117
Echinococcus granulosus snurportin 1 0.0973 0.4023 0.544
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0082 0.0106
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0531 0.4472
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0141 0.0421
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0076 0.0429
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0082 0.0078
Trichomonas vaginalis hypothetical protein 0.0015 0.0009 0.0044
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0067 0.0226 0.6916
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0067 0.0086
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0062 0.0204 0.0271
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.01 0.0362 0.0485
Echinococcus multilocularis translational activator gcn1 0.0017 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0048 0.0144 0.0359
Trichomonas vaginalis importin beta-1, putative 0.0074 0.0255 0.2188
Brugia malayi beta-lactamase family protein 0.0035 0.0091 0.0272
Loa Loa (eye worm) hypothetical protein 0.01 0.0362 0.09
Schistosoma mansoni cpg binding protein 0.0132 0.0498 0.0669
Brugia malayi nuclear hormone receptor 0.0062 0.0204 0.0609
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.1152 0.5
Schistosoma mansoni nuclear receptor 0.0029 0.0067 0.0086
Echinococcus multilocularis microtubule associated protein 2 0.1655 0.6879 0.6878
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0091 0.0743
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0067 0.0086
Schistosoma mansoni hypothetical protein 0.0089 0.032 0.0428
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0204 0.0609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0551 0.0548
Toxoplasma gondii pantoate-beta-alanine ligase 0.0625 0.2564 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0091 0.0342
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0067 0.0201
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.0362 0.0485
Schistosoma mansoni myst-related protein 0.0015 0.0007 0.0004
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0032 0.008 0.024
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0039 0.0107 0.014
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0076 0.0616

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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