Detailed information for compound 546528

Basic information

Technical information
  • TDR Targets ID: 546528
  • Name: (E)-3-amino-2-[(3,5-ditert-butyl-4-oxo-cycloh exa-2,5-dien-1-ylidene)methyl]-3-sulfanyl-pro p-2-enenitrile
  • MW: 316.461 | Formula: C18H24N2OS
  • H donors: 1 H acceptors: 2 LogP: 4.05 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C(/S)\N)/C=C/1\C=C(C(=O)C(=C1)C(C)(C)C)C(C)(C)C
  • InChi: 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,22H,20H2,1-6H3/b16-12+
  • InChiKey: LCUMYVYIHXYBIA-FOWTUZBSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-amino-2-[(3,5-ditert-butyl-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-mercapto-2-propenenitrile
  • (E)-3-azanyl-2-[(3,5-ditert-butyl-4-oxo-cyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanyl-prop-2-enenitrile
  • (E)-3-amino-2-[(3,5-ditert-butyl-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]-3-mercapto-acrylonitrile
  • (E)-3-amino-2-[(3,5-ditert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile
  • AG-879
  • (E)-3-amino-2-[(3,5-ditert-butyl-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-sulfanylprop-2-enenitrile
  • 3-amino-2-[(3,5-ditert-butyl-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-sulfanylprop-2-enenitrile
  • (E)-3-amino-2-[(3,5-ditert-butyl-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-sulfanyl-prop-2-enenitrile
  • 3-amino-2-[(3,5-ditert-butyl-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-sulfanyl-prop-2-enenitrile
  • 3-amino-2-[(3,5-ditert-butyl-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-mercaptoprop-2-enenitrile
  • (E)-3-amino-2-[(3,5-ditert-butyl-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-mercaptoprop-2-enenitrile
  • 3-amino-2-[(3,5-ditert-butyl-4-keto-1-cyclohexa-2,5-dienylidene)methyl]-3-mercapto-acrylonitrile
  • (E)-3-amino-2-[(3,5-ditert-butyl-4-keto-1-cyclohexa-2,5-dienylidene)methyl]-3-mercapto-acrylonitrile
  • 148741-30-4
  • NCGC00094432-03
  • NCGC00016007-01
  • Lopac-T-2067
  • 2-Propenethioamide, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-, (E)-
  • AG 879
  • NCGC00094432-04
  • T2067_SIGMA
  • Tyrphostin AG 879
  • alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
  • EU-0101175

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0137 0.1539
Schistosoma mansoni cpg binding protein 0.0028 0.0086 0.0084
Loa Loa (eye worm) hypothetical protein 0.0118 0.0411 0.0409
Leishmania major glycerol uptake protein, putative 0.024 0.0848 1
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0021 0.0061 0.0059
Brugia malayi nuclear receptor RXR 0.0005 0.0004 0.0002
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0019
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0117 0.8968
Mycobacterium ulcerans lipase LipD 0.0035 0.0113 0.1594
Schistosoma mansoni thyroid hormone receptor 0.001 0.0021 0.0019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0305 0.0303
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.024 0.0848 1
Onchocerca volvulus Huntingtin homolog 0.0118 0.0411 0.4836
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0113 0.0946
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0019
Mycobacterium ulcerans hypothetical protein 0.0035 0.0113 0.1594
Brugia malayi Hhat protein 0.024 0.0848 0.0846
Entamoeba histolytica hypothetical protein, conserved 0.024 0.0848 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0113 0.1594
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.0061 0.0523
Trypanosoma brucei glycerol uptake protein, putative 0.024 0.0848 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0019
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0086 0.0084
Leishmania major glycerol uptake protein, putative 0.024 0.0848 1
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0067 0.0385
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0117 0.0115
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0113 0.1007
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.024 0.0848 0.0846
Brugia malayi beta-lactamase family protein 0.0035 0.0113 0.0111
Echinococcus granulosus Aminotransferase class III 0.0021 0.0061 0.0059
Loa Loa (eye worm) acetyltransferase 0.0144 0.0502 0.0501
Echinococcus multilocularis RUN 0.002 0.0055 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0021 0.0019
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0502 0.0501
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0117 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0021 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0021 0.0019
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0113 0.1594
Schistosoma mansoni coup transcription factor 0.001 0.0021 0.0019
Mycobacterium tuberculosis Conserved protein 0.0035 0.0113 0.1007
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.024 0.0848 0.0846
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0125 0.0909
Echinococcus granulosus o acyltransferase membrane bound domain 0.024 0.0848 0.0846
Schistosoma mansoni lipoxygenase 0.0117 0.0406 0.0404
Entamoeba histolytica hypothetical protein 0.0071 0.0241 0.2377
Mycobacterium ulcerans beta-lactamase 0.0035 0.0113 0.1594
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0036 0.0034
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0117 0.0115
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0305 0.0303
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0113 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0004 0.0002
Loa Loa (eye worm) doublecortin family protein 0.002 0.0055 0.0054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0199 0.0197
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.1613 0.1612
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0117 0.1299
Echinococcus granulosus ornithine aminotransferase 0.0021 0.0061 0.0059
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0111
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0113 0.1245
Brugia malayi nuclear receptor NHR-88 0.001 0.0021 0.0019
Brugia malayi hypothetical protein 0.0071 0.0241 0.024
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.1419 0.1417
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0111
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.024 0.0848 0.0846
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0305 0.0303
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0021 0.0019
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0052 0.0527
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0021 0.0019
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0021 0.0019
Mycobacterium leprae Probable lipase LipE 0.0035 0.0113 0.1594
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0113 0.1007
Schistosoma mansoni hypothetical protein 0.0399 0.1419 0.1417
Entamoeba histolytica vacuolar protein sorting 26 0.024 0.0848 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0021 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0054
Brugia malayi MBOAT family protein 0.024 0.0848 0.0846
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.0406 0.0404
Schistosoma mansoni bromodomain containing protein 0.0005 0.0004 0.0002
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.024 0.0848 0.0846
Echinococcus granulosus muscleblind protein 0.0146 0.0511 0.0509
Echinococcus granulosus dnaJ subfamily B 0.0399 0.1419 0.1417
Loa Loa (eye worm) cytochrome P450 0.0014 0.0036 0.0034
Onchocerca volvulus 0.001 0.0021 0.0221
Loa Loa (eye worm) hypothetical protein 0.0146 0.0511 0.0509
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0021 0.0061 0.0059
Trichomonas vaginalis esterase, putative 0.0035 0.0113 0.1245
Mycobacterium tuberculosis Conserved protein 0.0035 0.0113 0.1007
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0113 0.1245
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.024 0.0848 1
Brugia malayi Cytochrome P450 family protein 0.0014 0.0036 0.0034
Toxoplasma gondii exonuclease III APE 0.0019 0.0052 0.0204
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0016 0.0014
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.0406 0.0404
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0111
Brugia malayi hypothetical protein 0.0005 0.0004 0.0002
Echinococcus granulosus FTZ F1 alpha 0.001 0.0021 0.0019
Echinococcus multilocularis 0.0014 0.0036 0.0034
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.024 0.0848 0.0846
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.0799 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0021 0.0019
Onchocerca volvulus 0.0035 0.0113 0.1308
Mycobacterium ulcerans hypothetical protein 0.0148 0.0518 1
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0055 0.0041
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0021 0.0019
Mycobacterium tuberculosis Conserved protein 0.0035 0.0113 0.1007
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.024 0.0848 0.0846
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0021 0.0019
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0502 0.0501
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0305 0.0303
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0021 0.0019
Schistosoma mansoni rab6-interacting 0.002 0.0055 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0021 0.0019
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0067 0.0385
Schistosoma mansoni rab6-interacting 0.002 0.0055 0.0054
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0052 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0021 0.0019
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0113 0.0111
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0021 0.0019
Onchocerca volvulus 0.0035 0.0113 0.1308
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0052 0.0204
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0305 0.0303
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0117 0.0115
Echinococcus multilocularis cpg binding protein 0.003 0.0092 0.009
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0113 0.1007
Loa Loa (eye worm) beta-lactamase 0.0035 0.0113 0.0111
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0117 0.0115
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0117 0.1003
Schistosoma mansoni zinc finger protein 0.0005 0.0004 0.0002
Trichomonas vaginalis transmembrane protein nessy, putative 0.024 0.0848 1
Onchocerca volvulus 0.0028 0.0086 0.0992
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0021 0.0019
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0113 0.1245
Loa Loa (eye worm) MBOAT family protein 0.024 0.0848 0.0846
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0055 0.0054
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0511 0.0509
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0021 0.0019
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0113 0.1007
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0137 0.0135
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0021 0.0061 0.0331
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.1613 0.1612
Brugia malayi diacylglycerol acyltransferase 0.024 0.0848 0.0846
Loa Loa (eye worm) hypothetical protein 0.024 0.0848 0.0846
Schistosoma mansoni hypothetical protein 0.002 0.0055 0.0054
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0021 0.0019
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0005 0.0004 0.0002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0189 0.1882
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0021 0.0019
Treponema pallidum alginate O-acetylation protein (algI) 0.024 0.0848 1
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0055 0.0054
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.2785 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0117 0.1003
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0055 0.0654
Leishmania major cytochrome p450-like protein 0.0023 0.0067 0.0385
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0021 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.024 0.0848 1
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0021 0.0061 0.0331
Schistosoma mansoni ap endonuclease 0.0019 0.0052 0.005
Onchocerca volvulus 0.024 0.0848 1
Echinococcus granulosus membrane bound acyltransferase:hhat 0.024 0.0848 0.0846
Toxoplasma gondii hypothetical protein 0.024 0.0848 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0021 0.0019
Leishmania major glycerol uptake protein, putative 0.024 0.0848 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0021 0.0019
Echinococcus granulosus cpg binding protein 0.003 0.0092 0.009
Entamoeba histolytica hypothetical protein 0.0071 0.0241 0.2377
Brugia malayi Cytochrome P450 family protein 0.0052 0.0172 0.017
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0002
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0117 0.1003
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0002
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0052 0.005
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0113 0.1245
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0052 0.005
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0052 0.0616
Schistosoma mansoni lipoxygenase 0.0082 0.0279 0.0278
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0021 0.0061 0.0523
Trypanosoma cruzi glycerol uptake protein, putative 0.024 0.0848 1
Brugia malayi MBOAT family protein 0.024 0.0848 0.0846
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0061 0.0059
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0117 0.0115
Entamoeba histolytica hypothetical protein 0.0071 0.0241 0.2377
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.001 0.0008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0021 0.0019
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0241 0.024
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0067 0.0065
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0113 0.1007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0021 0.0019
Echinococcus granulosus o acyltransferase membrane bound domain 0.024 0.0848 0.0846
Brugia malayi cytochrome P450 0.0014 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0002
Leishmania major hypothetical protein, conserved 0.0035 0.0113 0.0946
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.024 0.0848 0.0846
Schistosoma mansoni cytochrome P450 0.0014 0.0036 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0305 0.0303
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.001 0.0008
Brugia malayi Cytochrome P450 family protein 0.0023 0.0067 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0305 0.0303
Leishmania major glycerol uptake protein, putative 0.024 0.0848 1
Plasmodium falciparum diacylglycerol O-acyltransferase 0.024 0.0848 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0241 0.024
Mycobacterium ulcerans acetylornithine aminotransferase 0.0021 0.0061 0.0523
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0021 0.0019
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0113 0.1007
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0137 0.125
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.001 0.0008
Echinococcus multilocularis zinc finger protein 0.0005 0.0004 0.0002
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0148 0.0518 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0021 0.0019
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.024 0.0848 0.0846
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0052 0.0527
Brugia malayi MBOAT family protein 0.024 0.0848 0.0846
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0137 0.125
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0021 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0113 0.0946
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0117 0.1003
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0004 0.0002
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0021 0.0221
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0021 0.0061 0.0331
Loa Loa (eye worm) hhat protein 0.024 0.0848 0.0846
Brugia malayi hypothetical protein 0.0118 0.0411 0.0409
Onchocerca volvulus 0.002 0.0055 0.0634
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0137 0.1618
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.024 0.0848 0.0846
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.024 0.0848 0.0846
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0021 0.0061 0.0523
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0021 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0113 0.0111
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.024 0.0848 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0784 0.2805 0.2804
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0113 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0021 0.0019
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0067 0.0385
Brugia malayi PHD-finger family protein 0.0005 0.0004 0.0002
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0067 0.0648
Brugia malayi Bromodomain containing protein 0.0005 0.0004 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0113 0.1245
Trichomonas vaginalis conserved hypothetical protein 0.024 0.0848 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0015
Trypanosoma cruzi glycerol uptake protein, putative 0.024 0.0848 1
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0021 0.0019
Onchocerca volvulus Huntingtin homolog 0.0118 0.0411 0.4836
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0021 0.0019
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0117 0.0815
Mycobacterium tuberculosis Probable aminotransferase 0.0148 0.0518 0.6318
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0054
Echinococcus granulosus zinc finger protein 0.0005 0.0004 0.0002
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0021 0.0019
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.024 0.0848 0.0846
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0052 0.0204
Loa Loa (eye worm) hypothetical protein 0.0037 0.0117 0.0115
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0125 0.0909
Schistosoma mansoni cpg binding protein 0.003 0.0092 0.009
Trichomonas vaginalis conserved hypothetical protein 0.024 0.0848 1
Trypanosoma cruzi GUP1, putative 0.024 0.0848 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.024 0.0848 0.0846
Echinococcus multilocularis sterol O acyltransferase 1 0.024 0.0848 0.0846
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0021 0.0019
Toxoplasma gondii ABC1 family protein 0.0035 0.0113 0.0946
Loa Loa (eye worm) hypothetical protein 0.0118 0.0411 0.0409
Schistosoma mansoni nuclear hormone receptor 0.001 0.0021 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0021 0.0019
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0005 0.0004 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0305 0.0303
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0021 0.0019
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0021 0.0061 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0146 0.0511 0.0509
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0021 0.0019
Trypanosoma cruzi GUP1, putative 0.024 0.0848 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0021 0.0019
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.024 0.0848 0.0846
Brugia malayi Muscleblind-like protein 0.0146 0.0511 0.0509
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0002
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0148 0.0518 0.6318
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0021 0.0061 0.0523
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.001 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0021 0.0019
Brugia malayi beta-lactamase family protein 0.0035 0.0113 0.0111
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0004 0.0002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0021 0.0019
Schistosoma mansoni hypothetical protein 0.0071 0.0241 0.024
Trypanosoma cruzi glycerol uptake protein, putative 0.024 0.0848 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0021 0.0019
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0117 0.0115
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0021 0.0019
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0117 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0113 0.0946
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0113 0.0111
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0021 0.0061 0.5
Brugia malayi hypothetical protein 0.002 0.0055 0.0054
Brugia malayi ecdysteroid receptor 0.001 0.0021 0.0019
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0019
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0117 0.1299
Loa Loa (eye worm) hhat protein 0.024 0.0848 0.0846
Trypanosoma brucei glycerol uptake protein, putative 0.024 0.0848 1
Trichomonas vaginalis porcupine, putative 0.024 0.0848 1
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0016 0.0014
Schistosoma mansoni zinc finger protein 0.2785 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0021 0.0019
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.024 0.0848 0.0846
Echinococcus multilocularis zinc finger protein 0.2545 0.9137 0.9137
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.024 0.0848 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.024 0.0848 0.0846
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0148 0.0518 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0021 0.0019
Brugia malayi hypothetical protein 0.0005 0.0004 0.0002
Plasmodium falciparum ornithine aminotransferase 0.0021 0.0061 0.0109
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0172 0.017
Brugia malayi nuclear hormone receptor 0.001 0.0021 0.0019
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0052 0.0217
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0502 0.0501
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0061 0.0059
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.1613 0.1612
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0019
Echinococcus multilocularis Aminotransferase class III 0.0021 0.0061 0.0059
Loa Loa (eye worm) diacylglycerol acyltransferase 0.024 0.0848 0.0846
Onchocerca volvulus 0.0035 0.0113 0.1308
Loa Loa (eye worm) MBOAT family protein 0.2785 1 1
Mycobacterium ulcerans L-lysine aminotransferase 0.0021 0.0061 0.0523
Echinococcus granulosus neuropeptide s receptor 0.0453 0.1613 0.1612
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0055 0.0054
Brugia malayi MBOAT family protein 0.024 0.0848 0.0846
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.2785 1 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0016 0.0014
Brugia malayi beta-lactamase 0.0035 0.0113 0.0111
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0021 0.0019
Schistosoma mansoni polycystin 1-related 0.002 0.0055 0.0054
Brugia malayi Doublecortin family protein 0.002 0.0055 0.0054
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0055 0.0054
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0052 0.0204
Entamoeba histolytica hypothetical protein 0.0071 0.0241 0.2377
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0113 0.1594
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0305 0.0303
Brugia malayi CXXC zinc finger family protein 0.0028 0.0086 0.0084
Schistosoma mansoni hypothetical protein 0.0014 0.0036 0.0034
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0021 0.0019
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0052 0.0204
Schistosoma mansoni thyroid hormone receptor 0.001 0.0021 0.0019
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0021 0.0061 0.0523
Plasmodium vivax ornithine aminotransferase, putative 0.0021 0.0061 0.0718
Echinococcus granulosus RUN 0.002 0.0055 0.0054
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0113 0.0111
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0113 0.1327
Brugia malayi steroid hormone receptor 0.001 0.0021 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0021 0.0019
Brugia malayi hypothetical protein 0.002 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.024 0.0848 0.0846
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0021 0.0061 0.0523
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0111
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0021 0.0221
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0148 0.0518 0.6071
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0117 0.0115
Onchocerca volvulus 0.002 0.0055 0.0634
Leishmania major hypothetical protein, conserved 0.024 0.0848 1
Schistosoma mansoni sterol O-acyltransferase 1 0.024 0.0848 0.0846
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0052 0.005
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.024 0.0848 0.0846
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0021 0.0019
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.024 0.0848 0.0846
Echinococcus granulosus sterol O acyltransferase 1 0.024 0.0848 0.0846
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.024 0.0848 1
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0125 1
Schistosoma mansoni cpg binding protein 0.003 0.0092 0.009
Leishmania major glycerol uptake protein, putative 0.024 0.0848 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0117 0.1299
Loa Loa (eye worm) hypothetical protein 0.024 0.0848 0.0846
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0067 0.0065
Echinococcus granulosus lysophospholipid acyltransferase 7 0.024 0.0848 0.0846
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0111
Schistosoma mansoni loxhd1 0.002 0.0055 0.0054
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0241 0.024
Entamoeba histolytica hypothetical protein 0.024 0.0848 1
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.024 0.0848 0.0846
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.024 0.0848 1
Schistosoma mansoni ap endonuclease 0.0019 0.0052 0.005
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0021 0.0019
Echinococcus granulosus zinc finger protein 0.2545 0.9137 0.9137
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0021 0.0061 0.0311
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0021 0.0061 0.0331
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0137 0.1539
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0004 0.0002
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0488 0.0486
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0052 0.005
Schistosoma mansoni bromodomain containing protein 0.0005 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.024 0.0848 0.0846
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0002
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0055 0.0054
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.001 0.0008
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0067 0.0065
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.0061 0.0523
Echinococcus multilocularis muscleblind protein 0.0146 0.0511 0.0509
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0113 0.1007
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0019
Brugia malayi Cytochrome P450 family protein 0.0023 0.0067 0.0065
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0111
Loa Loa (eye worm) MBOAT family protein 0.024 0.0848 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0021 0.0019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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