Detailed information for compound 549125

Basic information

Technical information
  • TDR Targets ID: 549125
  • Name: ammonia; ethyl dihydrogen phosphate
  • MW: 160.109 | Formula: C2H13N2O4P
  • H donors: 4 H acceptors: 3 LogP: -4.93 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOP(=O)(O)O.N.N
  • InChi: 1S/C2H7O4P.2H3N/c1-2-6-7(3,4)5;;/h2H2,1H3,(H2,3,4,5);2*1H3
  • InChiKey: XRVFPYDPBSDLAD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • azane; ethyl dihydrogen phosphate
  • 24856-79-9
  • Diammonium ethyl phosphate
  • EINECS 246-500-4
  • Phosphoric acid, monoethyl ester, diammonium salt

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0083 0.0786 0.0786
Brugia malayi MBOAT family protein 0.0083 0.0786 0.0784
Schistosoma mansoni hypothetical protein 0.0039 0.0323 0.0323
Schistosoma mansoni lamin 0.0031 0.0238 0.0238
Schistosoma mansoni sterol O-acyltransferase 1 0.0083 0.0786 0.0786
Mycobacterium ulcerans hypothetical protein 0.0114 0.1105 0.3416
Loa Loa (eye worm) hypothetical protein 0.0014 0.0066 0.0064
Entamoeba histolytica hypothetical protein 0.0083 0.0777 0.989
Echinococcus multilocularis muscleblind protein 0.0649 0.6675 0.6675
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0606 0.0606
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2032 0.2031
Schistosoma mansoni intermediate filament proteins 0.0031 0.0238 0.0238
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2324 0.7208
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0264 0.0801
Schistosoma mansoni smad1 5 8 and 0.0009 0.0009 0.0009
Echinococcus multilocularis inositol monophosphatase 0.0009 0.0006 0.0006
Echinococcus multilocularis microtubule associated protein 2 0.0791 0.8147 0.8147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.1441 0.1441
Brugia malayi MH2 domain containing protein 0.0009 0.0009 0.0006
Trichomonas vaginalis esterase, putative 0.0114 0.1105 0.3425
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0105 0.0103
Loa Loa (eye worm) hypothetical protein 0.0083 0.0786 0.0784
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0114 0.1105 0.1103
Schistosoma mansoni pyruvate kinase 0.0033 0.0264 0.0264
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.034 0.4312
Onchocerca volvulus 0.0114 0.1105 0.4752
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0008 0.0002 0.0002
Schistosoma mansoni cellular tumor antigen P53 0.0105 0.1006 0.1006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0606 0.0606
Leishmania major pyruvate kinase 0.0033 0.0264 0.2375
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.1441 0.1441
Loa Loa (eye worm) hypothetical protein 0.0083 0.0786 0.0784
Echinococcus multilocularis tumor protein p63 0.0715 0.7362 0.7362
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.1105 0.1105
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0083 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0031 0.0238 0.0236
Schistosoma mansoni synaptojanin 0.0008 0.0002 0.0002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0606 0.0606
Onchocerca volvulus 0.0114 0.1105 0.4752
Echinococcus granulosus neuropeptide s receptor 0.0451 0.4611 0.4611
Trichomonas vaginalis transmembrane protein nessy, putative 0.0083 0.0786 0.2432
Brugia malayi CXXC zinc finger family protein 0.0028 0.0208 0.0206
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0089 0.0087
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0083 0.0786 0.0786
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0498 0.0496
Echinococcus granulosus beta LACTamase domain containing family member 0.0114 0.1105 0.1105
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.034 0.034
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.034 0.4312
Onchocerca volvulus 0.0031 0.0238 0.1017
Schistosoma mansoni pyruvate kinase 0.0033 0.0264 0.0264
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0083 0.0786 0.0786
Mycobacterium ulcerans bacterioferritin BfrB 0.001 0.0018 0.0035
Leishmania major glycerol uptake protein, putative 0.0083 0.0786 0.7102
Brugia malayi MH1 domain containing protein 0.0009 0.0009 0.0006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0238 0.0236
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0606 0.5476
Trypanosoma brucei hypothetical protein, conserved 0.0114 0.1105 1
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0009 0.0006 0.0006
Echinococcus granulosus pyruvate kinase 0.0017 0.0095 0.0095
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0225 0.0225
Mycobacterium leprae conserved hypothetical protein 0.0114 0.1105 1
Giardia lamblia Pyruvate kinase 0.0017 0.0095 0.275
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.034 0.1049
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0264 0.0262
Echinococcus granulosus sterol O acyltransferase 1 0.0083 0.0786 0.0786
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0009 0.0006 0.004
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0082 0.0774 0.2396
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0459 0.0457
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0606 0.1865
Brugia malayi Muscleblind-like protein 0.0649 0.6675 0.6674
Mycobacterium tuberculosis Conserved protein 0.0114 0.1105 0.1469
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.034 0.034
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0114 0.1105 0.1469
Schistosoma mansoni ferritin 0.001 0.0018 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.1441 0.1441
Schistosoma mansoni hypothetical protein 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0072 0.007
Loa Loa (eye worm) MBOAT family protein 0.0083 0.0786 0.0784
Schistosoma mansoni myo inositol monophosphatase 0.0009 0.0006 0.0006
Brugia malayi glutaminase DH11.1 0.0318 0.3223 0.3222
Echinococcus granulosus o acyltransferase membrane bound domain 0.0083 0.0786 0.0786
Echinococcus multilocularis GPCR, family 2 0.0018 0.0105 0.0105
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0009 0.0006
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0108 0.0957
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1105 0.3425
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0606 0.5476
Plasmodium vivax hypothetical protein, conserved 0.0114 0.1105 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0159 0.0157
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0009 0.0006 0.004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0208 0.0208
Schistosoma mansoni apoferritin-2 0.001 0.0018 0.0018
Onchocerca volvulus 0.0105 0.1006 0.4326
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0114 0.1105 0.1469
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0002 0.0002
Echinococcus granulosus zinc finger protein 0.0885 0.9131 0.9131
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0108 0.0108
Schistosoma mansoni lamin 0.0031 0.0238 0.0238
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0108 0.0957
Onchocerca volvulus 0.0031 0.0238 0.1017
Leishmania major hypothetical protein, conserved 0.0083 0.0786 0.7102
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.034 1
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.4611 0.4611
Loa Loa (eye worm) hypothetical protein 0.0014 0.0066 0.0064
Brugia malayi beta-lactamase family protein 0.0114 0.1105 0.1103
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.034 0.3063
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0083 0.0786 1
Entamoeba histolytica hypothetical protein 0.0083 0.0777 0.989
Trypanosoma brucei glycerol uptake protein, putative 0.0083 0.0786 0.7102
Brugia malayi beta-lactamase family protein 0.0114 0.1105 0.1103
Schistosoma mansoni microtubule-associated protein tau 0.0791 0.8147 0.8147
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.034 0.4312
Loa Loa (eye worm) hypothetical protein 0.0083 0.0786 0.0784
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1105 0.3425
Trichomonas vaginalis inositol monophosphatase, putative 0.0009 0.0006 0.0014
Echinococcus granulosus o acyltransferase membrane bound domain 0.0083 0.0786 0.0786
Echinococcus granulosus microtubule associated protein 2 0.0791 0.8147 0.8147
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0225 0.0225
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0108 0.0957
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0225 0.0225
Brugia malayi MBOAT family protein 0.0083 0.0786 0.0784
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0264 0.2345
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0114 0.1105 0.3416
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.034 0.1037
Schistosoma mansoni hypothetical protein 0.0018 0.0105 0.0105
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0082 0.0774 1
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.034 0.0338
Brugia malayi hypothetical protein 0.0083 0.0777 0.0775
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0108 0.0957
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0095 0.1186
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0498 0.0498
Trypanosoma cruzi glycerol uptake protein, putative 0.0083 0.0786 0.7102
Mycobacterium tuberculosis Possible penicillin-binding protein 0.073 0.7511 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0498 0.0498
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0033 0.0264 0.0262
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0008 0.0002 0.0002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0105 0.0105
Toxoplasma gondii hypothetical protein 0.0083 0.0786 0.7102
Brugia malayi diacylglycerol acyltransferase 0.0083 0.0786 0.0784
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1105 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0108 0.0108
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0271 0.2742 0.274
Loa Loa (eye worm) hypothetical protein 0.0649 0.6675 0.6674
Mycobacterium ulcerans lipase LipD 0.0114 0.1105 0.3416
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0008 0.0002 0.0002
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0008 0.0002 0.0002
Brugia malayi beta-lactamase 0.0114 0.1105 0.1103
Schistosoma mansoni hypothetical protein 0.0083 0.0777 0.0777
Brugia malayi MH2 domain containing protein 0.0009 0.0009 0.0006
Schistosoma mansoni hypothetical protein 0.0194 0.1938 0.1938
Schistosoma mansoni pyruvate kinase 0.0017 0.0095 0.0095
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0083 0.0786 0.0786
Schistosoma mansoni ferritin 0.001 0.0018 0.0018
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0774 0.6996
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0264 0.0814
Echinococcus multilocularis musashi 0.0031 0.0238 0.0238
Trypanosoma cruzi GUP1, putative 0.0083 0.0786 0.7102
Treponema pallidum alginate O-acetylation protein (algI) 0.0083 0.0786 1
Echinococcus granulosus Smad4 0.0009 0.0009 0.0009
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0083 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0057 0.0511 0.0509
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0264 0.0262
Loa Loa (eye worm) hypothetical protein 0.003 0.0232 0.023
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0083 0.0786 0.0786
Trichomonas vaginalis glutaminase, putative 0.0318 0.3223 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0511 0.0509
Echinococcus multilocularis pyruvate kinase 0.0033 0.0264 0.0264
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0105 0.0105
Echinococcus granulosus neutral sphingomyelinase 0.0008 0.0002 0.0002
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.034 0.3063
Loa Loa (eye worm) hypothetical protein 0.0114 0.1105 0.1103
Echinococcus granulosus lamin dm0 0.0031 0.0238 0.0238
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0108 0.0108
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.034 0.1049
Mycobacterium tuberculosis Conserved protein 0.0114 0.1105 0.1469
Echinococcus granulosus synaptojanin 1 0.0008 0.0002 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1105 0.3425
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.034 0.045
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0108 0.1348
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0108 0.0108
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0511 0.0509
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0238 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0786 0.2432
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.0018 0.0021
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0083 0.0786 0.0784
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0009 0.0006 0.004
Mycobacterium tuberculosis Probable esterase LipL 0.0114 0.1105 0.1469
Loa Loa (eye worm) hypothetical protein 0.0105 0.1006 0.1005
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0264 0.0262
Loa Loa (eye worm) hypothetical protein 0.0114 0.1105 0.1103
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0606 0.0606
Mycobacterium tuberculosis Probable hydrolase 0.0114 0.1105 0.1469
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.1441 0.1441
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.1105 0.1105
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.1266 0.1264
Schistosoma mansoni hypothetical protein 0.0194 0.1938 0.1938
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0264 0.2375
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0082 0.0774 0.6996
Echinococcus multilocularis geminin 0.0194 0.1938 0.1938
Loa Loa (eye worm) beta-lactamase 0.0114 0.1105 0.1103
Trichomonas vaginalis inositol monophosphatase, putative 0.0082 0.0774 0.2396
Echinococcus multilocularis neutral sphingomyelinase 0.0008 0.0002 0.0002
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0009 0.0009
Trypanosoma cruzi GUP1, putative 0.0083 0.0786 0.7102
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0082 0.0774 0.2386
Entamoeba histolytica hypothetical protein 0.0083 0.0777 0.989
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0083 0.0786 1
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.4611 0.4611
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0009 0.0009
Mycobacterium leprae Probable lipase LipE 0.0114 0.1105 1
Mycobacterium tuberculosis Probable lipase LipE 0.0114 0.1105 0.1469
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0498 0.4494
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0017 0.0015
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0225 0.2025
Schistosoma mansoni glutaminase 0.0318 0.3223 0.3223
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0105 0.0105
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0606 0.0805
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.034 0.3063
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0083 0.0786 0.0786
Leishmania major myo-inositol-1 phosphatase, putative 0.0009 0.0006 0.004
Schistosoma mansoni neutral sphingomyelinase 0.0008 0.0002 0.0002
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0083 0.0786 0.7102
Mycobacterium tuberculosis Conserved protein 0.0114 0.1105 0.1469
Loa Loa (eye worm) hypothetical protein 0.0114 0.1105 0.1103
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0969 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0498 0.1528
Echinococcus multilocularis lamin dm0 0.0031 0.0238 0.0238
Schistosoma mansoni ferritin light chain 0.001 0.0018 0.0018
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0108 0.0106
Loa Loa (eye worm) MBOAT family protein 0.0969 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0105 0.0103
Leishmania major pyruvate kinase 0.0033 0.0264 0.2375
Echinococcus granulosus o acyltransferase membrane bound domain 0.0083 0.0786 0.0786
Trichomonas vaginalis inositol monophosphatase, putative 0.0009 0.0006 0.0014
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0009 0.0006 0.0019
Schistosoma mansoni apoferritin-2 0.001 0.0018 0.0018
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0264 0.1129
Entamoeba histolytica hypothetical protein 0.0083 0.0786 1
Entamoeba histolytica hypothetical protein, conserved 0.0083 0.0786 1
Leishmania major glycerol uptake protein, putative 0.0083 0.0786 0.7102
Brugia malayi MBOAT family protein 0.0083 0.0786 0.0784
Schistosoma mansoni ferritin light chain 0.001 0.0018 0.0018
Schistosoma mansoni ap endonuclease 0.0041 0.034 0.034
Plasmodium falciparum pyruvate kinase 0.0033 0.0264 0.3345
Schistosoma mansoni transcription factor LCR-F1 0.0083 0.0777 0.0777
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0264 0.1129
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.4062 0.4062
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.034 0.3063
Echinococcus granulosus tumor protein p63 0.0715 0.7362 0.7362
Loa Loa (eye worm) hypothetical protein 0.0114 0.1105 0.1103
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0095 0.0842
Echinococcus multilocularis ferritin 0.001 0.0018 0.0018
Loa Loa (eye worm) Smad1 0.0009 0.0009 0.0006
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.1266 0.1264
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0786 0.2432
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.1441 0.1441
Echinococcus granulosus ferritin 0.001 0.0018 0.0018
Echinococcus multilocularis lamin 0.0031 0.0238 0.0238
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.0018 0.0021
Schistosoma mansoni cpg binding protein 0.0028 0.0208 0.0208
Schistosoma mansoni hypothetical protein 0.0398 0.4062 0.4062
Echinococcus multilocularis pyruvate kinase 0.0017 0.0095 0.0095
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0108 0.0108
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0511 0.0509
Brugia malayi MH1 domain containing protein 0.0009 0.0009 0.0006
Schistosoma mansoni hypothetical protein 0.0018 0.0105 0.0105
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0264 0.2375
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0083 0.0786 1
Trichomonas vaginalis ferritin, putative 0.001 0.0018 0.0049
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0083 0.0777 0.0777
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0072 0.0072
Echinococcus granulosus expressed protein 0.001 0.0018 0.0018
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0083 0.0786 1
Echinococcus multilocularis pyruvate kinase 0.0017 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0018 0.0105 0.0103
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0108 0.0108
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0009 0.0009
Echinococcus multilocularis beta LACTamase domain containing family member 0.0114 0.1105 0.1105
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0114 0.1105 0.1103
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0606 0.1865
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0009 0.0006 0.004
Onchocerca volvulus 0.0028 0.0208 0.0886
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0083 0.0786 0.0786
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0083 0.0786 0.7102
Echinococcus granulosus pyruvate kinase 0.0033 0.0264 0.0264
Leishmania major glycerol uptake protein, putative 0.0083 0.0786 0.7102
Loa Loa (eye worm) MBOAT family protein 0.0083 0.0786 0.0784
Brugia malayi MBOAT family protein 0.0083 0.0786 0.0784
Echinococcus granulosus pyruvate kinase 0.0017 0.0095 0.0095
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0009 0.0006 0.0014
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0264 0.0814
Brugia malayi Inositol-1 0.0082 0.0774 0.0772
Schistosoma mansoni inositol monophosphatase 0.0082 0.0774 0.0774
Toxoplasma gondii hypothetical protein 0.0009 0.0006 0.004
Echinococcus multilocularis traf and tnf receptor associated protein 0.0008 0.0002 0.0002
Treponema pallidum bacterioferrin (TpF1) 0.001 0.0018 0.02
Echinococcus multilocularis Smad4 0.0009 0.0009 0.0009
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0009 0.0006 0.0056
Schistosoma mansoni synaptojanin 0.0008 0.0002 0.0002
Schistosoma mansoni cpg binding protein 0.003 0.0224 0.0224
Loa Loa (eye worm) hhat protein 0.0083 0.0786 0.0784
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0108 0.0108
Echinococcus granulosus muscleblind protein 0.0649 0.6675 0.6675
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0083 0.0786 0.0786
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0002 0.0002
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0083 0.0786 0.0786
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0498 0.1528
Schistosoma mansoni hypothetical protein 0.0083 0.0786 0.0786
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0114 0.1105 0.1469
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0083 0.0786 0.0786
Echinococcus granulosus cpg binding protein 0.003 0.0224 0.0224
Schistosoma mansoni ferritin 0.001 0.0018 0.0018
Schistosoma mansoni inositol monophosphatase 0.0082 0.0774 0.0774
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0009 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0786 0.2432
Mycobacterium tuberculosis Probable lipase LipD 0.0114 0.1105 0.1469
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0009 0.0009
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0083 0.0786 0.0786
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.1441 0.1439
Echinococcus multilocularis pyruvate kinase 0.0026 0.0191 0.0191
Loa Loa (eye worm) histone methyltransferase 0.001 0.0018 0.0016
Brugia malayi intermediate filament protein 0.0031 0.0238 0.0236
Onchocerca volvulus 0.003 0.0225 0.0962
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.1441 0.1441
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0264 0.0262
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0323 0.0321
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0082 0.0774 0.2396
Echinococcus granulosus traf and tnf receptor associated protein 0.0008 0.0002 0.0002
Echinococcus multilocularis synaptojanin 1 0.0008 0.0002 0.0002
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0264 0.0349
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0774 0.6996
Giardia lamblia Pyruvate kinase 0.0033 0.0264 0.7756
Echinococcus multilocularis cpg binding protein 0.003 0.0224 0.0224
Echinococcus multilocularis pyruvate kinase 0.0033 0.0264 0.0264
Loa Loa (eye worm) inositol-1 0.0082 0.0774 0.0772
Schistosoma mansoni smad 0.0009 0.0009 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.034 0.3063
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0009 0.0009
Echinococcus granulosus pyruvate kinase 0.0017 0.0095 0.0095
Plasmodium vivax SET domain protein, putative 0.003 0.0225 0.2025
Onchocerca volvulus 0.0231 0.2324 1
Brugia malayi Inositol monophosphatase family protein 0.0009 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0039 0.0323 0.0321
Echinococcus multilocularis expressed protein 0.001 0.0018 0.0018
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0108 0.0141
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0969 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0105 0.0105
Schistosoma mansoni hypothetical protein 0.0018 0.0105 0.0105
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0009 0.0006 0.004
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0108 0.0957
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0083 0.0777 0.0777
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Echinococcus granulosus inositol monophosphatase 0.0009 0.0006 0.0006
Onchocerca volvulus 0.0114 0.1105 0.4752
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0108 0.0106
Brugia malayi MH2 domain containing protein 0.013 0.1266 0.1264
Echinococcus granulosus inositol monophosphatase 1 0.0082 0.0774 0.0774
Loa Loa (eye worm) hypothetical protein 0.0649 0.6675 0.6674
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0225 0.0225
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0498 0.066
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0083 0.0786 0.0786
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0083 0.0786 0.0786
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0108 0.0957
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0072 0.0072
Toxoplasma gondii exonuclease III APE 0.0041 0.034 0.3063
Schistosoma mansoni cript-related 0.0008 0.0002 0.0002
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0774 0.6996
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0774 0.6996
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0095 0.0842
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0264 0.2375
Loa Loa (eye worm) hypothetical protein 0.0114 0.1105 0.1103
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0157
Leishmania major hypothetical protein, conserved 0.0114 0.1105 1
Mycobacterium ulcerans glutaminase 0.0318 0.3223 1
Schistosoma mansoni carbon catabolite repressor protein 0.0008 0.0002 0.0002
Mycobacterium ulcerans esterase/lipase LipP 0.0114 0.1105 0.3416
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.034 0.0338
Echinococcus granulosus lamin 0.0031 0.0238 0.0238
Brugia malayi Hhat protein 0.0083 0.0786 0.0784
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0105 0.0103
Mycobacterium ulcerans bacterioferritin BfrA 0.001 0.0018 0.0035
Brugia malayi Smad1 0.0009 0.0009 0.0006
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0074 0.0684 0.0908
Brugia malayi Pre-SET motif family protein 0.003 0.0225 0.0223
Schistosoma mansoni hypothetical protein 0.0008 0.0002 0.0002
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0089 0.0087
Trichomonas vaginalis porcupine, putative 0.0083 0.0786 0.2432
Loa Loa (eye worm) glutaminase 0.0318 0.3223 0.3222
Echinococcus multilocularis deoxyribonuclease 1 2 0.0008 0.0002 0.0002
Schistosoma mansoni ap endonuclease 0.0041 0.034 0.034
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Brugia malayi follicle stimulating hormone receptor 0.0271 0.2742 0.274
Echinococcus granulosus GPCR family 2 0.0018 0.0105 0.0105
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.001 0.0018 0.0103
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.034 0.4261
Echinococcus granulosus pyruvate kinase 0.0033 0.0264 0.0264
Giardia lamblia Hypothetical protein 0.0009 0.0006 0.0129
Brugia malayi isocitrate dehydrogenase 0.0018 0.0108 0.0106
Entamoeba histolytica hypothetical protein 0.0083 0.0777 0.989
Echinococcus multilocularis smad 0.0009 0.0009 0.0009
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0074 0.0684 0.6166
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.1105 0.3425
Echinococcus multilocularis pyruvate kinase 0.0017 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0083 0.0786 0.0784
Loa Loa (eye worm) hypothetical protein 0.003 0.0225 0.0223
Schistosoma mansoni pap-inositol-14-phosphatase 0.0009 0.0006 0.0006
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0009 0.0006 0.0056
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0008 0.0002 0.0002
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0108 0.0957
Schistosoma mansoni ferritin 0.001 0.0018 0.0018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.1441 0.1439
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0159 0.2003
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0264 0.1129
Toxoplasma gondii ABC1 family protein 0.0114 0.1105 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0009 0.0009
Mycobacterium ulcerans beta-lactamase 0.0114 0.1105 0.3416
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0082 0.0774 0.9851
Trypanosoma cruzi glycerol uptake protein, putative 0.0083 0.0786 0.7102
Entamoeba histolytica vacuolar protein sorting 26 0.0083 0.0786 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.1105 0.1103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0225 0.0225
Trypanosoma brucei glycerol uptake protein, putative 0.0083 0.0786 0.7102
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0208 0.0206
Leishmania major glycerol uptake protein, putative 0.0083 0.0786 0.7102
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0264 0.2375
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.1105 0.3425
Echinococcus granulosus smad 0.0009 0.0009 0.0009
Schistosoma mansoni Smad4 0.0009 0.0009 0.0009
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0238 0.0236
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0083 0.0786 0.0784
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0083 0.0786 0.0786
Schistosoma mansoni smad1 5 8 and 0.0009 0.0009 0.0009
Schistosoma mansoni nocturnin 0.0008 0.0002 0.0002
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0083 0.0786 0.7102
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0225 0.0225
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0108 0.0957
Brugia malayi Pre-SET motif family protein 0.0203 0.2032 0.2031
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0264 0.2375
Echinococcus multilocularis muscleblind protein 1 0.0649 0.6675 0.6675
Trypanosoma cruzi glycerol uptake protein, putative 0.0083 0.0786 0.7102
Schistosoma mansoni hypothetical protein 0.0018 0.0105 0.0105
Brugia malayi Inositol monophosphatase family protein 0.0009 0.0006 0.0004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0545 0.0545
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0264 0.0262
Leishmania major glycerol uptake protein, putative 0.0083 0.0786 0.7102
Echinococcus multilocularis inositol monophosphatase 1 0.0082 0.0774 0.0774
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0479 0.4325
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0606 0.1865
Echinococcus granulosus dnaJ subfamily B 0.0398 0.4062 0.4062
Chlamydia trachomatis pyruvate kinase 0.0033 0.0264 1
Onchocerca volvulus 0.0083 0.0786 0.3375
Schistosoma mansoni zinc finger protein 0.0969 1 1
Mycobacterium tuberculosis Probable monophosphatase 0.0009 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0009 0.0006 0.0006
Echinococcus multilocularis zinc finger protein 0.0885 0.9131 0.9131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0225 0.0225
Mycobacterium tuberculosis Monophosphatase CysQ 0.0009 0.0006 0.0006
Loa Loa (eye worm) hhat protein 0.0083 0.0786 0.0784
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0083 0.0786 0.0786
Echinococcus granulosus intermediate filament protein 0.0031 0.0238 0.0238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.1441 0.1441
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0264 0.2375
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1105 1
Loa Loa (eye worm) glutaminase 2 0.0318 0.3223 0.3222
Echinococcus granulosus geminin 0.0194 0.1938 0.1938
Schistosoma mansoni cpg binding protein 0.003 0.0224 0.0224
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0009 0.0006 0.0014
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.4611 0.4611
Echinococcus multilocularis sterol O acyltransferase 1 0.0083 0.0786 0.0786
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0022 0.002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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