Detailed information for compound 552802

Basic information

Technical information
  • TDR Targets ID: 552802
  • Name: 3-acetyl T-2 toxin
  • MW: 508.558 | Formula: C26H36O10
  • H donors: 0 H acceptors: 4 LogP: 1.5 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)OC[C@]12C[C@H](OC(=O)CC(C)C)C(=C[C@H]1O[C@H]1C3([C@]2(C)[C@H](OC(=O)C)[C@H]1OC(=O)C)OC3)C
  • InChi: 1S/C26H36O10/c1-13(2)8-20(30)35-18-10-25(11-31-15(4)27)19(9-14(18)3)36-23-21(33-16(5)28)22(34-17(6)29)24(25,7)26(23)12-32-26/h9,13,18-19,21-23H,8,10-12H2,1-7H3/t18-,19+,21+,22+,23+,24+,25+,26?/m0/s1
  • InChiKey: NOTOVTQRFFVBSB-ZYWOEDSGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 21259-21-2
  • 3-Acetyl T-2
  • Acetyl T-2
  • BRN 6494202
  • T-2 acetate
  • Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 3,4,15-triacetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)-
  • Trichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol, 12,13-epoxy-, 3,4,15-triacetate, 8-isovalerate
  • 12,13-Epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol 3,4,15-triacetate 8-isovalerate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0035 0.0209 0.0547
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0199 0.2174 0.5883
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0079 0.0112
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.029 0.1045
Brugia malayi hypothetical protein 0.0034 0.0204 0.0288
Brugia malayi hypothetical protein 0.0609 0.7069 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.029 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0198 0.0698
Echinococcus multilocularis raf serine:threonine protein kinase 0.0019 0.0019 0.0004
Onchocerca volvulus 0.0034 0.0198 0.0532
Loa Loa (eye worm) hypothetical protein 0.0035 0.0209 0.0547
Echinococcus granulosus laminin 0.0042 0.0295 0.0332
Brugia malayi hypothetical protein 0.0034 0.0204 0.0288
Onchocerca volvulus 0.0034 0.0198 0.0532
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0079 0.3561
Leishmania major hypothetical protein, conserved 0.0055 0.0454 0.1446
Echinococcus multilocularis intersectin 2 0.0035 0.0213 0.0199
Brugia malayi nuclear receptor NHR-88 0.0065 0.0568 0.0804
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0518
Loa Loa (eye worm) hypothetical protein 0.0034 0.0204 0.0533
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0344 0.0913
Schistosoma mansoni C-fyn 0.0034 0.0198 0.0217
Schistosoma mansoni RAR-like nuclear receptor 0.0065 0.0568 0.0655
Loa Loa (eye worm) TK/FER protein kinase 0.0047 0.0361 0.096
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0208 0.023
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0351 0.0397
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0546
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2174 0.2551
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0241 0.2672 1
Echinococcus multilocularis SH2 domain containing protein 7 0.0035 0.0208 0.0194
Echinococcus multilocularis tensin 0.0035 0.0208 0.0194
Brugia malayi nuclear receptor RXR 0.0031 0.016 0.0226
Loa Loa (eye worm) hypothetical protein 0.0065 0.0568 0.1524
Schistosoma mansoni tyrosine kinase 0.0081 0.0764 0.0885
Echinococcus multilocularis tyrosine protein kinase Blk 0.0292 0.3287 0.3278
Schistosoma mansoni nuclear hormone receptor 0.0031 0.016 0.0172
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0042 0.0295 0.0417
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0326 0.369 0.4342
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.029 0.1045
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0079 0.5
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0079 0.3561
Leishmania major protein kinase A catalytic subunit 0.0241 0.2672 1
Schistosoma mansoni alpha-glucosidase 0.0161 0.1716 0.201
Loa Loa (eye worm) STAT protein 0.0035 0.0208 0.0546
Brugia malayi Myosin tail family protein 0.0034 0.0198 0.028
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0209 0.023
Echinococcus granulosus signal transduction protein lnk realted 0.0035 0.0208 0.023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0209 0.023
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0065 0.0568 0.0804
Mycobacterium ulcerans hypothetical protein 0.0024 0.0079 0.3561
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0518
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0079 0.5
Echinococcus multilocularis transmembrane protease serine 3 0.0035 0.0209 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0568 0.0804
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0079 0.3561
Loa Loa (eye worm) TK/FER protein kinase 0.0047 0.0361 0.096
Brugia malayi Furin-like cysteine rich region family protein 0.0159 0.169 0.2391
Entamoeba histolytica PH domain containing protein kinase, putative 0.0241 0.2672 0.9279
Schistosoma mansoni hypothetical protein 0.0035 0.0209 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0065 0.0568 0.1524
Loa Loa (eye worm) hypothetical protein 0.0027 0.0112 0.0286
Schistosoma mansoni formin binding protein and related proteins 0.0034 0.0198 0.0217
Schistosoma mansoni growth factor receptor-bound protein 0.0068 0.0611 0.0705
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0206 0.0367
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0546
Echinococcus multilocularis lamin dm0 0.0031 0.0165 0.015
Brugia malayi nuclear hormone receptor family member odr-7 0.0031 0.016 0.0226
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0546
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0035 0.0208 0.0546
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0344 0.0389
Echinococcus granulosus RNA directed DNA polymerase 0.0039 0.0259 0.0289
Brugia malayi SH2 domain containing protein 0.0035 0.0208 0.0295
Echinococcus granulosus growth factor receptor bound protein 2 0.0068 0.0611 0.0705
Brugia malayi tailless protein 0.0031 0.016 0.0226
Schistosoma mansoni alpha glucosidase 0.0041 0.029 0.0326
Brugia malayi Cytochrome P450 family protein 0.0049 0.038 0.0537
Loa Loa (eye worm) SRC-1 0.0326 0.369 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0031 0.016 0.0172
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0546
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0546
Loa Loa (eye worm) hypothetical protein 0.0258 0.2874 0.7785
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0206 0.0747
Echinococcus multilocularis epidermal growth factor receptor 0.0159 0.169 0.1678
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0065 0.0568 0.0804
Echinococcus multilocularis lamin 0.0031 0.0165 0.015
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0292 0.3287 0.3866
Loa Loa (eye worm) TK/FER protein kinase 0.0047 0.0361 0.096
Toxoplasma gondii calcium binding egf domain-containing protein 0.0042 0.0295 0.0712
Onchocerca volvulus 0.0035 0.0208 0.0562
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0326 0.369 0.3681
Schistosoma mansoni suppressor of cytokine signaling 0.0035 0.0208 0.0229
Toxoplasma gondii kringle domain-containing protein 0.0055 0.0454 0.1335
Schistosoma mansoni tyrosine kinase 0.0081 0.0764 0.0885
Echinococcus multilocularis transfer RNA-Ala 0.0034 0.0198 0.0184
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0034 0.0198 0.0217
Echinococcus multilocularis geminin 0.0358 0.4076 0.4068
Loa Loa (eye worm) hypothetical protein 0.0042 0.0295 0.078
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.0415
Loa Loa (eye worm) hypothetical protein 0.0031 0.0165 0.0427
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0065 0.0568 0.0555
Brugia malayi hypothetical protein 0.0031 0.016 0.0226
Onchocerca volvulus 0.0035 0.0208 0.0562
Brugia malayi SRC-1 0.0326 0.369 0.522
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0326 0.369 0.4342
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0568 0.0655
Schistosoma mansoni tyrosine kinase 0.0159 0.169 0.1979
Onchocerca volvulus Putative cortactin 0.0034 0.0198 0.0532
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0065 0.0568 0.0655
Brugia malayi Sex muscle abnormal protein 5 0.0068 0.0611 0.0865
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0209 0.023
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0042 0.0295 0.078
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0019 0.0022 0.0008
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0035 0.0209 0.023
Loa Loa (eye worm) TK/FER protein kinase 0.0047 0.0361 0.096
Entamoeba histolytica hypothetical protein 0.0034 0.0198 0.0426
Echinococcus granulosus tyrosine kinase 0.0292 0.3287 0.3866
Brugia malayi Guanylate kinase family protein 0.0034 0.0198 0.028
Giardia lamblia Kinase, AGC PKA 0.0241 0.2672 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0055 0.0454 0.1677
Brugia malayi Tensin 0.0035 0.0208 0.0295
Mycobacterium ulcerans arylsulfatase AtsD 0.0018 0.0012 0.0251
Echinococcus multilocularis musashi 0.0031 0.0165 0.015
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0241 0.2672 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0295 0.078
Schistosoma mansoni signal transduction protein lnk-related 0.0035 0.0208 0.0229
Schistosoma mansoni eps8-related protein 0.0034 0.0198 0.0217
Echinococcus multilocularis laminin 0.0042 0.0295 0.0281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0065 0.0568 0.1524
Brugia malayi Trypsin family protein 0.0035 0.0209 0.0295
Trichomonas vaginalis AGC family protein kinase 0.0241 0.2672 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0165 0.0427
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0546
Echinococcus multilocularis epidermal growth factor receptor 0.0091 0.0879 0.0866
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0568 0.0555
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0068 0.0611 0.164
Loa Loa (eye worm) SH2 domain-containing protein 0.0035 0.0208 0.0546
Loa Loa (eye worm) hypothetical protein 0.031 0.3503 0.9493
Schistosoma mansoni nuclear receptor nhr-48 0.0031 0.016 0.0172
Brugia malayi Protein kinase domain containing protein 0.0059 0.0498 0.0704
Echinococcus multilocularis Mastin 0.0035 0.0209 0.0195
Echinococcus granulosus glycoprotein Antigen 5 0.0035 0.0209 0.023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0568 0.0804
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0326 0.369 0.3681
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1298 0.3504
Echinococcus multilocularis nuclear receptor nhr 48 0.0031 0.016 0.0146
Echinococcus multilocularis tyrosine protein kinase ABL1 0.025 0.2784 0.2774
Onchocerca volvulus 0.0047 0.0361 0.0998
Brugia malayi hypothetical protein 0.0035 0.0208 0.0295
Schistosoma mansoni hypothetical protein 0.0035 0.0208 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0198 0.0698
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0241 0.2672 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0209 0.023
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0112 0.0395
Toxoplasma gondii AGC kinase 0.0241 0.2672 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.016 0.0172
Brugia malayi Trypsin family protein 0.031 0.3503 0.4956
Schistosoma mansoni hypothetical protein 0.0035 0.0209 0.023
Brugia malayi Kringle domain containing protein 0.0055 0.0454 0.0642
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0041 0.0279 0.0265
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0546
Leishmania major hypothetical protein, conserved 0.0034 0.0206 0.0491
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0208 0.023
Brugia malayi SH2 domain containing protein 0.0035 0.0208 0.0295
Entamoeba histolytica protein kinase, putative 0.0038 0.0243 0.0588
Echinococcus granulosus intermediate filament protein 0.0031 0.0165 0.0178
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0198 0.0335
Loa Loa (eye worm) hypothetical protein 0.0024 0.0079 0.0195
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0568 0.0804
Onchocerca volvulus Huntingtin homolog 0.0252 0.2806 0.8002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0065 0.0568 0.1524
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0204 0.0288
Echinococcus granulosus epidermal growth factor receptor 0.0159 0.169 0.198
Loa Loa (eye worm) TK/ABL protein kinase 0.025 0.2784 0.754
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0198 0.028
Entamoeba histolytica SH2 domain containing protein 0.0035 0.0208 0.0463
Echinococcus multilocularis endophilin A3 0.0034 0.0198 0.0184
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0478 0.0547
Echinococcus granulosus tyrosine protein kinase Src64B 0.0326 0.369 0.4342
Echinococcus multilocularis nostrin 0.0034 0.0198 0.0184
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0209 0.023
Echinococcus multilocularis c src tyrosine kinase 0.0081 0.0764 0.075
Brugia malayi RNA recognition motif domain containing protein 0.0199 0.2174 0.3075
Echinococcus multilocularis 0.0045 0.0338 0.0324
Schistosoma mansoni tyrosine kinase 0.0047 0.0361 0.0409
Echinococcus granulosus NCK adaptor protein 0.0068 0.0611 0.0705
Echinococcus granulosus tyrosine protein kinase ABL1 0.025 0.2784 0.3272
Mycobacterium tuberculosis Probable sulfatase 0.0018 0.0012 0.0706
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0034 0.0198 0.0518
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0034 0.0198 0.0184
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0079 0.3561
Echinococcus multilocularis Spectrin alpha actinin 0.0034 0.0198 0.0184
Trichomonas vaginalis p67phox protein, putative 0.0034 0.0198 0.0698
Loa Loa (eye worm) hypothetical protein 0.0065 0.0568 0.1524
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0079 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0568 0.1524
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0034 0.0204 0.019
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0326 0.369 0.3681
Onchocerca volvulus 0.0055 0.0454 0.1266
Brugia malayi Fes/CIP4 homology domain containing protein 0.0034 0.0198 0.028
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0042 0.0295 0.0331
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0034 0.0204 0.0224
Brugia malayi hypothetical protein 0.0252 0.2806 0.3969
Brugia malayi RNA binding protein 0.0199 0.2174 0.3075
Onchocerca volvulus 0.0035 0.0208 0.0562
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0035 0.0208 0.0562
Onchocerca volvulus 0.0035 0.0209 0.0563
Schistosoma mansoni lamin 0.0031 0.0165 0.0177
Loa Loa (eye worm) RNA binding protein 0.0199 0.2174 0.5883
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.029 0.1045
Entamoeba histolytica hypothetical protein 0.0034 0.0198 0.0426
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0198 0.0426
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0065 0.0568 0.0655
Mycobacterium ulcerans arylsulfatase AtsB 0.0018 0.0012 0.0251
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0241 0.2672 1
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0241 0.2672 0.314
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0568 0.0655
Schistosoma mansoni dreadlocks/dock 0.0034 0.0198 0.0217
Brugia malayi nuclear receptor RXR 0.0034 0.0204 0.0288
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0206 0.0541
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.016 0.0146
Schistosoma mansoni lamin 0.0031 0.0165 0.0177
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0344 0.033
Leishmania major hypothetical protein, conserved 0.0027 0.0112 0.0129
Schistosoma mansoni tyrosine kinase 0.0078 0.0727 0.0842
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0568 0.0804
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0065 0.0568 0.0655
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.002
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0035 0.0208 0.0194
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0326 0.369 0.3681
Loa Loa (eye worm) hypothetical protein 0.0065 0.0568 0.1524
Echinococcus granulosus c src tyrosine kinase 0.0081 0.0764 0.0885
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0035 0.0208 0.0194
Brugia malayi Nuclear hormone receptor E75 0.0031 0.016 0.0226
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.0415
Brugia malayi SH2 domain containing protein 0.0035 0.0208 0.0295
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.0415
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0035 0.0208 0.0194
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0241 0.2672 1
Loa Loa (eye worm) p53BP2 0.0034 0.0198 0.0518
Schistosoma mansoni tyrosine kinase 0.0022 0.0058 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0198 0.0698
Schistosoma mansoni egf-like domain protein 0.0042 0.0295 0.0331
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0241 0.2672 1
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0568 0.0655
Schistosoma mansoni tyrosine kinase 0.0059 0.0498 0.0571
Brugia malayi hypothetical protein 0.0031 0.016 0.0226
Mycobacterium tuberculosis Possible hydrolase 0.0018 0.0012 0.0706
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0344 0.0389
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0034 0.0198 0.0518
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0241 0.2672 0.2662
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0326 0.369 0.3681
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0241 0.2672 1
Onchocerca volvulus Bile acid receptor homolog 0.0065 0.0568 0.1593
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0079 0.0112
Echinococcus multilocularis tyrosine protein kinase HCK 0.0258 0.2874 0.2864
Loa Loa (eye worm) hypothetical protein 0.0034 0.0204 0.0533
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0238 0.2637 0.2627
Loa Loa (eye worm) AGC/PKA protein kinase 0.0241 0.2672 0.7237
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0047 0.0361 0.1008
Brugia malayi steroid hormone receptor 0.0065 0.0568 0.0804
Entamoeba histolytica protein kinase, putative 0.0258 0.2874 1
Brugia malayi hypothetical protein 0.0035 0.0209 0.0295
Entamoeba histolytica PH domain containing protein kinase, putative 0.0241 0.2672 0.9279
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2174 0.2551
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0209 0.023
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0065 0.0568 0.0804
Loa Loa (eye worm) hypothetical protein 0.0047 0.0361 0.096
Loa Loa (eye worm) hypothetical protein 0.031 0.3503 0.9493
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0209 0.023
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0035 0.0208 0.0194
Echinococcus granulosus tyrosine protein kinase Lyn 0.0329 0.3725 0.4384
Onchocerca volvulus 0.0034 0.0198 0.0532
Loa Loa (eye worm) trypsin family protein 0.0035 0.0209 0.0547
Schistosoma mansoni tyrosine kinase 0.0091 0.0879 0.1022
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0241 0.2672 0.2662
Echinococcus granulosus tyrosine protein kinase Src42A 0.0326 0.369 0.4342
Schistosoma mansoni hypothetical protein 0.0035 0.0208 0.0229
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0019 0.0022 0.0009
Echinococcus multilocularis thyroid hormone receptor alpha 0.0065 0.0568 0.0555
Brugia malayi Variant SH3 domain containing protein 0.0068 0.0611 0.0865
Mycobacterium ulcerans sulfatase 0.0018 0.0012 0.0251
Loa Loa (eye worm) hypothetical protein 0.0034 0.0204 0.0533
Brugia malayi SH2 domain containing protein 0.0047 0.0361 0.051
Entamoeba histolytica BAR/SH3 domain containing protein 0.0034 0.0198 0.0426
Brugia malayi cytokine inducible SH2-containing protein 5 0.0035 0.0208 0.0295
Echinococcus granulosus epidermal growth factor receptor 0.0091 0.0879 0.1022
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0079 0.3561
Schistosoma mansoni growth factor receptor-bound protein 0.0068 0.0611 0.0705
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0035 0.0208 0.0194
Brugia malayi hypothetical protein 0.0018 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0546
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0065 0.0568 0.0655
Loa Loa (eye worm) TK/FER protein kinase 0.0047 0.0361 0.096
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0209 0.023
Onchocerca volvulus 0.0035 0.0209 0.0563
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0198 0.028
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0241 0.2672 1
Entamoeba histolytica hypothetical protein 0.0034 0.0198 0.0426
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0241 0.2672 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0546
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0206 0.0367
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0518
Onchocerca volvulus 0.0031 0.016 0.0423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0065 0.0568 0.1524
Echinococcus granulosus SH2 domain containing protein 7 0.0035 0.0208 0.023
Brugia malayi Fibulin-1 precursor 0.0042 0.0295 0.0417
Brugia malayi Steroid receptor seven-up type 2 0.0065 0.0568 0.0804
Onchocerca volvulus Huntingtin homolog 0.0252 0.2806 0.8002
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0035 0.0209 0.0195
Loa Loa (eye worm) guanylate kinase 0.0034 0.0198 0.0518
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0034 0.0198 0.0184
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0241 0.2672 0.2662
Loa Loa (eye worm) SH2 domain-containing protein 0.0035 0.0208 0.0546
Brugia malayi nuclear hormone receptor 0.0065 0.0568 0.0804
Schistosoma mansoni nck2/grb4 0.0068 0.0611 0.0705
Brugia malayi Src substrate cortactin 0.0034 0.0198 0.028
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0209 0.0195
Echinococcus granulosus SH2 motif 0.0035 0.0208 0.023
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0206 0.0747
Loa Loa (eye worm) hypothetical protein 0.0252 0.2806 0.7599
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0034 0.0198 0.0532
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0292 0.3287 0.3278
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0065 0.0568 0.1593
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0079 0.3561
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0241 0.2672 0.314
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0241 0.2672 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0065 0.0568 0.0804
Loa Loa (eye worm) TK/FER protein kinase 0.0047 0.0361 0.096
Schistosoma mansoni nuclear receptor 0.0031 0.016 0.0172
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.0415
Leishmania major protein kinase A catalytic subunit isoform 2 0.0241 0.2672 1
Schistosoma mansoni tyrosine kinase 0.0059 0.0498 0.0571
Echinococcus multilocularis tar DNA binding protein 0.0199 0.2174 0.2163
Echinococcus granulosus Protein kinase C brain isozyme 0.0057 0.0478 0.0548
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.029 0.0756
Mycobacterium ulcerans hydrolase 0.0018 0.0012 0.0251
Brugia malayi Nuclear hormone receptor-like 1 0.0065 0.0568 0.0804
Brugia malayi RhoGAP domain containing protein 0.0041 0.0279 0.0395
Schistosoma mansoni tensin 0.0035 0.0208 0.0229
Brugia malayi Protein kinase domain containing protein 0.0047 0.0361 0.051
Brugia malayi Tyrosine-protein kinase abl-1 0.0159 0.169 0.2391
Entamoeba histolytica hypothetical protein 0.0034 0.0198 0.0426
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.031 0.3503 0.4121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0568 0.0804
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0344 0.0486
Brugia malayi SH2 domain containing protein 0.0035 0.0208 0.0295
Schistosoma mansoni hypothetical protein 0.0055 0.0454 0.052
Loa Loa (eye worm) hypothetical protein 0.0034 0.0204 0.0533
Brugia malayi nuclear receptor NHR-88 0.0031 0.016 0.0226
Loa Loa (eye worm) TK protein kinase 0.0292 0.3287 0.8906
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.2026 0.2015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.016 0.0146
Loa Loa (eye worm) hypothetical protein 0.0065 0.0568 0.1524
Loa Loa (eye worm) hypothetical protein 0.0035 0.0209 0.0547
Loa Loa (eye worm) protein-tyrosine kinase 0.0034 0.0198 0.0518
Echinococcus multilocularis tyrosine kinase 0.0047 0.0361 0.0347
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0065 0.0568 0.0555
Schistosoma mansoni tensin-related 0.0035 0.0208 0.0229
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0035 0.0209 0.023
Echinococcus granulosus fch and double sh3 domains protein 2 0.0034 0.0198 0.0217
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0165 0.0427
Loa Loa (eye worm) hypothetical protein 0.0252 0.2806 0.7599
Echinococcus granulosus suppressor of cytokine signaling 6 0.0035 0.0208 0.023
Schistosoma mansoni serine/threonine protein kinase 0.0241 0.2672 0.314
Echinococcus granulosus N chimaerin 0.0041 0.0279 0.0313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0065 0.0568 0.1524
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.0415
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.029 0.0695
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0035 0.0208 0.0194
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0206 0.0227
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0035 0.0208 0.0562
Echinococcus multilocularis N chimaerin 0.0041 0.0279 0.0265
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0209 0.023
Brugia malayi Spectrin alpha chain 0.0034 0.0198 0.028
Brugia malayi Variant SH3 domain containing protein 0.0068 0.0611 0.0865
Entamoeba histolytica hypothetical protein 0.0034 0.0198 0.0426
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0041 0.0279 0.0313
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0034 0.0198 0.0184
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0034 0.0204 0.0533
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0035 0.0208 0.0194
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0041 0.0279 0.0313
Brugia malayi hypothetical protein 0.0027 0.0112 0.0159
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.0415
Brugia malayi STAT protein, DNA binding domain containing protein 0.0035 0.0208 0.0295
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0209 0.023
Brugia malayi Peripheral plasma membrane protein CASK 0.0034 0.0198 0.028
Onchocerca volvulus 0.0035 0.0209 0.0563
Onchocerca volvulus 0.031 0.3503 1
Trypanosoma brucei conserved protein 0.0034 0.0198 0.0335
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0014
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0065 0.0568 0.0655
Onchocerca volvulus 0.0031 0.016 0.0423
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.016 0.0172
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0209 0.023
Brugia malayi Trypsin-like protease protein 5 0.0035 0.0209 0.0295
Plasmodium falciparum cysteine repeat modular protein 1 0.0055 0.0454 0.1677
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0038 0.0243 0.0588
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.038 0.1012
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0079 0.0112
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.016 0.0146
Loa Loa (eye worm) hypothetical protein 0.0045 0.033 0.0875
Onchocerca volvulus 0.0047 0.0361 0.0998
Brugia malayi SH3 domain containing protein 0.0034 0.0198 0.028
Mycobacterium ulcerans arylsulfatase, AslA 0.0018 0.0012 0.0251
Brugia malayi Protein kinase domain containing protein 0.0047 0.0361 0.051
Echinococcus granulosus tyrosine protein kinase HCK 0.0258 0.2874 0.3378
Echinococcus multilocularis glycoprotein Antigen 5 0.0035 0.0209 0.0195
Onchocerca volvulus 0.0047 0.0361 0.0998
Echinococcus multilocularis tissue type plasminogen activator 0.0055 0.0454 0.044
Echinococcus granulosus expressed conserved protein 0.0035 0.0208 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0198 0.0698
Loa Loa (eye worm) nuclear hormone receptor 0.0031 0.016 0.0415
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0187 0.2026 0.5483
Entamoeba histolytica protein kinase, putative 0.0034 0.0198 0.0426
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0031 0.016 0.0172
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0079 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0031 0.016 0.0415
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0081 0.0764 0.0885
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0091 0.0879 0.1022
Echinococcus multilocularis ecdysone induced protein 78C 0.0065 0.0568 0.0555
Brugia malayi tRNA modification GTPase TrmE family protein 0.0035 0.0208 0.0295
Brugia malayi SH2 domain containing protein 0.0035 0.0208 0.0295
Schistosoma mansoni nuclear hormone receptor 0.0031 0.016 0.0172
Schistosoma mansoni tensin 0.0035 0.0208 0.0229
Toxoplasma gondii calcium binding egf domain-containing protein 0.0042 0.0295 0.0712
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0034 0.0198 0.0184
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0065 0.0568 0.1524
Echinococcus granulosus hypothetical protein 0.0035 0.0208 0.023
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0079 0.3561
Schistosoma mansoni SH2A 0.0035 0.0208 0.0229
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0208 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0065 0.0568 0.0804
Loa Loa (eye worm) TK/FER protein kinase 0.0047 0.0361 0.096
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0209 0.023
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0042 0.0295 0.078
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0065 0.0568 0.0655
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0068 0.0611 0.0705
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0206 0.0192
Brugia malayi photoreceptor-specific nuclear receptor 0.0065 0.0568 0.0804
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.029 0.0695
Echinococcus multilocularis RNA directed DNA polymerase 0.0039 0.0259 0.0245
Echinococcus multilocularis enteropeptidase 0.0035 0.0209 0.0195
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.029 0.0756
Schistosoma mansoni apoptosis stimulating of P53 0.0034 0.0198 0.0217
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0198 0.028
Schistosoma mansoni serine/threonine protein kinase 0.0241 0.2672 0.314
Brugia malayi nuclear hormone receptor 0.0031 0.016 0.0226
Entamoeba histolytica hypothetical protein 0.0034 0.0198 0.0426
Echinococcus multilocularis SH2 motif 0.0035 0.0208 0.0194
Echinococcus granulosus lamin 0.0031 0.0165 0.0178
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0546
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0034 0.0198 0.0184
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0081 0.0764 0.075
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.029 0.0815
Loa Loa (eye worm) hypothetical protein 0.0042 0.0295 0.078
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0326 0.369 0.3681
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0065 0.0568 0.0804
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0454 0.1335
Brugia malayi Tyrosine-protein kinase abl-1 0.0125 0.1292 0.1828
Loa Loa (eye worm) TK/FER protein kinase 0.0047 0.0361 0.096
Onchocerca volvulus 0.0035 0.0208 0.0562
Loa Loa (eye worm) AGC/PKA protein kinase 0.0241 0.2672 0.7237
Echinococcus granulosus tyrosine protein kinase Fyn 0.0326 0.369 0.4342
Echinococcus granulosus lysosomal alpha glucosidase 0.0187 0.2026 0.2377
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0198 0.028
Echinococcus granulosus tyrosine protein kinase Blk 0.0292 0.3287 0.3866
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0025 0.0093 0.0232
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0206 0.0367
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0034 0.0198 0.0217
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0344 0.0389
Echinococcus granulosus tyrosine protein kinase Fyn 0.0326 0.369 0.4342
Schistosoma mansoni tyrosine kinase 0.0216 0.2371 0.2784
Echinococcus multilocularis tyrosine protein kinase Src42A 0.028 0.3135 0.3125
Schistosoma mansoni intermediate filament proteins 0.0031 0.0165 0.0177
Brugia malayi TAR-binding protein 0.0199 0.2174 0.3075
Mycobacterium ulcerans hypothetical protein 0.0035 0.0209 1
Echinococcus granulosus microtubule associated protein 2 0.0727 0.848 1
Brugia malayi Trypsin family protein 0.0035 0.0209 0.0295
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0018 0.0012 0.0706
Schistosoma mansoni tensin 0.0035 0.0208 0.0229
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0112 0.0395
Brugia malayi Protein kinase domain containing protein 0.0047 0.0361 0.051
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0065 0.0568 0.0655
Schistosoma mansoni tyrosine kinase 0.0078 0.0727 0.0842
Leishmania major hypothetical protein, conserved 0.0034 0.0198 0.0459
Schistosoma mansoni steroid hormone receptor ad4bp 0.0065 0.0568 0.0655
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0034 0.0198 0.0184
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0206 0.0367
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.016 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0198 0.0698
Onchocerca volvulus 0.0035 0.0209 0.0563
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.029 0.1045
Brugia malayi protein kinase C II. 0.0018 0.0014 0.002
Echinococcus granulosus nostrin 0.0034 0.0198 0.0217
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.016 0.0172
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0204 0.0288
Schistosoma mansoni retinoic acid receptor RXR 0.0065 0.0568 0.0655
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.029 0.1045
Echinococcus granulosus raf serine:threonine protein kinase 0.0019 0.0019 0.0005
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.2026 0.2015
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0165 0.0233
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.0415
Echinococcus multilocularis SHC transforming protein 3 0.0035 0.0208 0.0194
Onchocerca volvulus 0.0035 0.0208 0.0562
Echinococcus multilocularis signal transduction protein lnk realted 0.0035 0.0208 0.0194
Brugia malayi SH2 domain containing protein 0.0047 0.0361 0.051
Loa Loa (eye worm) hypothetical protein 0.0068 0.0611 0.164
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.016 0.0423
Echinococcus multilocularis tyrosine protein kinase Abl 0.0159 0.169 0.1678
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0518
Echinococcus granulosus enteropeptidase 0.0035 0.0209 0.023
Onchocerca volvulus 0.0276 0.309 0.8815
Schistosoma mansoni tensin-related 0.0035 0.0208 0.0229
Echinococcus granulosus tyrosine protein kinase Srms 0.0047 0.0361 0.041
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0241 0.2672 0.314
Echinococcus multilocularis Tolloid protein 1 0.0042 0.0295 0.0281
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0035 0.0208 0.023
Mycobacterium ulcerans arylsulfatase AtsD 0.0018 0.0012 0.0251
Loa Loa (eye worm) hypothetical protein 0.0065 0.0568 0.1524
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0007 0.5
Brugia malayi Trypsin family protein 0.0035 0.0209 0.0295
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0344 0.0389
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0209 0.023
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0018 0.0012 0.0706
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0209 0.023
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0035 0.0209 0.023
Trypanosoma brucei glucosidase, putative 0.0041 0.029 0.0695
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0208 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0198 0.0698
Onchocerca volvulus Tyrosine kinase homolog 0.0019 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0039 0.0259 0.0682
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2174 0.2551
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0198 0.028
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0057 0.0478 0.0464
Brugia malayi Sulfatase family protein 0.0018 0.0012 0.0017
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.029 0.1045
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0034 0.0198 0.0217
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0546
Echinococcus granulosus epidermal growth factor receptor kinase 0.0034 0.0198 0.0217
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.029 0.0769
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0206 0.0367
Loa Loa (eye worm) TK/FER protein kinase 0.0047 0.0361 0.096
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0039 0.0259 0.0245
Echinococcus granulosus expressed protein 0.0034 0.0198 0.0217
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0043 0.0308 0.0818
Echinococcus granulosus src region 0.0034 0.0198 0.0217
Schistosoma mansoni nuclear receptor 0.0031 0.016 0.0172
Echinococcus granulosus SHC transforming protein 3 0.0035 0.0208 0.023
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0035 0.0208 0.023
Echinococcus granulosus lamin dm0 0.0031 0.0165 0.0178
Loa Loa (eye worm) hypothetical protein 0.0024 0.0079 0.0195
Echinococcus granulosus thyroid hormone receptor alpha 0.0031 0.016 0.0172
Loa Loa (eye worm) hypothetical protein 0.0065 0.0568 0.1524
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0065 0.0568 0.0655
Brugia malayi orphan nuclear receptor NR2E1 0.0031 0.016 0.0226
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.029 0.1045
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.0415
Brugia malayi Augmenter of liver regeneration 0.0034 0.0206 0.0292
Onchocerca volvulus 0.0047 0.0361 0.0998
Echinococcus granulosus Spectrin alpha actinin 0.0034 0.0198 0.0217
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0018 0.0014 0.0019
Onchocerca volvulus Arrow homolog 0.0042 0.0295 0.0809
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0034 0.0198 0.0184
Echinococcus granulosus Mastin 0.0035 0.0209 0.023
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0034 0.0198 0.0217
Brugia malayi Protein kinase domain containing protein 0.0068 0.0607 0.0858
Entamoeba histolytica hypothetical protein 0.0034 0.0198 0.0426
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0065 0.0568 0.0555
Entamoeba histolytica BAR/SH3 domain containing protein 0.0034 0.0198 0.0426
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0568 0.0555
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0034 0.0198 0.0217
Brugia malayi nuclear receptor NHR-67 0.0031 0.016 0.0226
Brugia malayi protein-tyrosine kinase 0.0034 0.0198 0.028
Schistosoma mansoni tyrosine kinase 0.0326 0.369 0.4342
Entamoeba histolytica hypothetical protein 0.0034 0.0198 0.0426
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0042 0.0295 0.078
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0059 0.0498 0.0484
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0518
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.029 0.1045
Onchocerca volvulus 0.0065 0.0568 0.1593
Echinococcus granulosus Tolloid protein 1 0.0042 0.0295 0.0332
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0568 0.0655
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0568 0.0655
Echinococcus granulosus nuclear receptor nhr 48 0.0031 0.016 0.0172
Echinococcus granulosus ecdysone induced protein 78C 0.0065 0.0568 0.0655
Schistosoma mansoni hypothetical protein 0.0358 0.4076 0.4798
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0209 0.023
Echinococcus multilocularis expressed protein 0.0034 0.0198 0.0184
Loa Loa (eye worm) TK protein kinase 0.0019 0.0022 0.004
Schistosoma mansoni sorbin 0.0034 0.0198 0.0217
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0093 0.0131
Schistosoma mansoni dynamin-associated protein 0.0034 0.0198 0.0217
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0344 0.033
Loa Loa (eye worm) hypothetical protein 0.0042 0.0295 0.078
Loa Loa (eye worm) hypothetical protein 0.0034 0.0204 0.0533
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0068 0.0611 0.164
Loa Loa (eye worm) hypothetical protein 0.009 0.0874 0.2354
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0065 0.0568 0.0655
Schistosoma mansoni hypothetical protein 0.0358 0.4076 0.4798
Loa Loa (eye worm) TK/EGFR protein kinase 0.0159 0.169 0.4569
Onchocerca volvulus 0.0047 0.0361 0.0998
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0034 0.0198 0.0217
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0041 0.0279 0.0739
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0518
Brugia malayi ecdysone receptor 0.0031 0.016 0.0226
Schistosoma mansoni tyrosine kinase 0.0078 0.0727 0.0842
Loa Loa (eye worm) hypothetical protein 0.0035 0.0209 0.0547
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0241 0.2672 0.2662
Schistosoma mansoni run and tbc1 domain containing 0.0034 0.0198 0.0217
Leishmania major protein kinase A catalytic subunit isoform 1 0.0241 0.2672 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0198 0.0698
Brugia malayi Calcium binding EGF domain containing protein 0.0042 0.0295 0.0417
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0206 0.0367
Echinococcus granulosus geminin 0.0358 0.4076 0.4799
Loa Loa (eye worm) TK/FER protein kinase 0.0047 0.0361 0.096
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.029 0.0326
Loa Loa (eye worm) hypothetical protein 0.0024 0.0079 0.0195
Schistosoma mansoni Dab2-interacting protein-like 0.0034 0.0198 0.0217
Echinococcus multilocularis tensin 0.0035 0.0208 0.0194
Echinococcus multilocularis growth factor receptor bound protein 2 0.0068 0.0611 0.0598
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0034 0.0198 0.0698
Echinococcus granulosus tyrosine protein kinase Fyn 0.0326 0.369 0.4342
Echinococcus multilocularis fibrillin 1 0.0042 0.0295 0.0281
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0198 0.0426
Onchocerca volvulus 0.0035 0.0208 0.0562
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0198 0.0335
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0031 0.016 0.0172
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0478 0.0547
Loa Loa (eye worm) SH2 domain-containing protein 0.0035 0.0208 0.0546
Brugia malayi SH2 domain containing protein 0.0035 0.0208 0.0295
Schistosoma mansoni zinc finger protein 0.0031 0.016 0.0172
Loa Loa (eye worm) hypothetical protein 0.0035 0.0209 0.0547
Loa Loa (eye worm) TK protein kinase 0.0258 0.2874 0.7784
Loa Loa (eye worm) DR-78 0.0031 0.016 0.0415
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0241 0.2672 0.378
Echinococcus multilocularis insulin receptor 0.0059 0.0498 0.0484
Loa Loa (eye worm) hypothetical protein 0.0051 0.0404 0.1077
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0036 0.0223 0.0586
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0035 0.0208 0.0229
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0034 0.0204 0.0224
Echinococcus multilocularis tyrosine protein kinase shark 0.0047 0.0361 0.0347
Echinococcus granulosus tar DNA binding protein 0.0199 0.2174 0.2551
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0065 0.0568 0.0555
Brugia malayi SH2 domain containing protein 0.0035 0.0208 0.0295
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0518
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0047 0.0361 0.0347
Brugia malayi Variant SH3 domain containing protein 0.0036 0.0223 0.0316
Loa Loa (eye worm) hypothetical protein 0.0065 0.0568 0.1524
Brugia malayi Glycosyl hydrolases family 31 protein 0.0187 0.2026 0.2867
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0546
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0059 0.0498 0.0571
Schistosoma mansoni coup transcription factor 0.0065 0.0568 0.0655
Onchocerca volvulus 0.0035 0.0209 0.0563
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0047 0.0361 0.041
Loa Loa (eye worm) thyroid receptor interactor 0.0034 0.0198 0.0518
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0326 0.369 0.3681
Echinococcus granulosus protein kinase C gamma type 0.0051 0.0407 0.0464
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0568 0.0804
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0019 0.0005
Schistosoma mansoni vav2 0.0041 0.0279 0.0313
Echinococcus granulosus insulin receptor 0.0059 0.0498 0.0571
Schistosoma mansoni hypothetical protein 0.0034 0.0198 0.0217
Echinococcus granulosus roundabout 2 0.0018 0.0015 0.0001
Echinococcus granulosus SH2 motif 0.0035 0.0208 0.023
Brugia malayi protein-tyrosine kinase 0.0292 0.3287 0.465
Onchocerca volvulus 0.0024 0.0079 0.0191
Echinococcus granulosus tyrosine protein kinase shark 0.0047 0.0361 0.041
Onchocerca volvulus 0.0034 0.0198 0.0532
Schistosoma mansoni cell polarity protein 0.0034 0.0198 0.0217
Echinococcus multilocularis NCK adaptor protein 0.0068 0.0611 0.0598
Echinococcus granulosus SH2 domain containing adapter protein F 0.0035 0.0208 0.023
Schistosoma mansoni alpha-glucosidase 0.0161 0.1716 0.201
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.0415
Echinococcus granulosus tensin 0.0035 0.0208 0.023
Brugia malayi intermediate filament protein 0.0031 0.0165 0.0233
Loa Loa (eye worm) hypothetical protein 0.0055 0.0454 0.1213
Echinococcus granulosus tyrosine kinase 0.0047 0.0361 0.041
Echinococcus multilocularis SH2 motif 0.0035 0.0208 0.0194
Echinococcus multilocularis SH2 motif 0.0035 0.0208 0.0194
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0031 0.016 0.0146
Schistosoma mansoni adapter molecule crk 0.0068 0.0611 0.0705
Echinococcus granulosus tissue type plasminogen activator 0.0055 0.0454 0.052
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.029 0.0276
Echinococcus multilocularis serine threonine protein kinase 0.0051 0.0407 0.0393
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0081 0.0764 0.0885
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.0409
Schistosoma mansoni microtubule-associated protein tau 0.0727 0.848 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0518
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0065 0.0568 0.1524
Echinococcus multilocularis microtubule associated protein 2 0.0727 0.848 0.8477
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0041 0.0279 0.0313
Onchocerca volvulus 0.0047 0.0361 0.0998
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0034 0.0198 0.0217
Schistosoma mansoni suppressor of cytokine signaling 0.0035 0.0208 0.0229
Schistosoma mansoni sorting nexin 0.0034 0.0198 0.0217
Loa Loa (eye worm) TK/INSR protein kinase 0.0059 0.0498 0.1331
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0198 0.028
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.0415
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0065 0.0568 0.0655
Brugia malayi conserved hypotetical protein 0.0031 0.016 0.0226
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0035 0.0208 0.0229
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0326 0.369 0.3681
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.029 0.1045
Echinococcus granulosus intersectin 2 0.0035 0.0213 0.0235
Echinococcus granulosus FTZ F1 alpha 0.0065 0.0568 0.0655
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0034 0.0198 0.0217
Loa Loa (eye worm) TK/ROR protein kinase 0.0074 0.0681 0.1829
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0518
Brugia malayi Nuclear hormone receptor E75 0.0031 0.016 0.0226
Schistosoma mansoni tyrosine kinase 0.0326 0.369 0.4342
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.0415
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0034 0.0198 0.0217
Onchocerca volvulus 0.0108 0.1086 0.3075
Schistosoma mansoni shc transforming protein 0.0035 0.0208 0.0229
Onchocerca volvulus 0.0031 0.0165 0.0436
Echinococcus multilocularis tyrosine protein kinase Srms 0.0292 0.3287 0.3278
Brugia malayi Protein kinase c protein 2 0.0049 0.0379 0.0537
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0065 0.0568 0.0655
Loa Loa (eye worm) hypothetical protein 0.0031 0.016 0.0415
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2174 0.2551
Toxoplasma gondii AGC kinase 0.0241 0.2672 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.028 0.3135 0.3686
Schistosoma mansoni tar DNA-binding protein 0.0199 0.2174 0.2551
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0031 0.016 0.0226
Schistosoma mansoni serine/threonine protein kinase 0.0241 0.2672 0.314
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0034 0.0198 0.0335
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0112 0.0395
Echinococcus granulosus suppressor of cytokine signaling 7 0.0035 0.0208 0.023
Entamoeba histolytica unconventional myosin IB 0.0034 0.0198 0.0426
Brugia malayi MH2 domain containing protein 0.0126 0.1298 0.1836
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0546
Schistosoma mansoni tyrosine kinase 0.0047 0.0361 0.0409
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0022 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0204 0.0224
Brugia malayi Variant SH3 domain containing protein 0.0041 0.0279 0.0395
Brugia malayi Protein kinase domain containing protein 0.0047 0.0361 0.051
Schistosoma mansoni hypothetical protein 0.0034 0.0198 0.0217
Onchocerca volvulus Protein ultraspiracle homolog 0.0065 0.0568 0.1593
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0344 0.0389
Schistosoma mansoni GTPase activating protein 0.0035 0.0208 0.0229
Loa Loa (eye worm) hypothetical protein 0.0241 0.2672 0.7237
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.029 0.0695
Onchocerca volvulus 0.0037 0.0233 0.0633
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0031 0.016 0.0415
Brugia malayi Protein kinase domain containing protein 0.0047 0.0361 0.051
Schistosoma mansoni tyrosine kinase 0.0091 0.0879 0.1022
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1298 0.3504
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0031 0.016 0.0146
Echinococcus multilocularis 0.0035 0.0208 0.0194
Brugia malayi ecdysteroid receptor 0.0065 0.0568 0.0804
Brugia malayi nuclear hormone receptor family member nhr-6 0.0031 0.016 0.0226
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0326 0.369 0.3681
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.031 0.3503 0.4121
Echinococcus granulosus transmembrane protease serine 3 0.0035 0.0209 0.023
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0198 0.0335
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0035 0.0209 0.0295
Loa Loa (eye worm) TAR-binding protein 0.0199 0.2174 0.5883
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0209 0.023
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0065 0.0568 0.0804
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0238 0.2637 0.3099
Echinococcus multilocularis FTZ F1 alpha 0.0065 0.0568 0.0555
Loa Loa (eye worm) steroid hormone receptor 0.0065 0.0568 0.1524
Onchocerca volvulus 0.0031 0.0165 0.0436
Brugia malayi hypothetical protein 0.0047 0.0361 0.051
Echinococcus granulosus endophilin A3 0.0034 0.0198 0.0217

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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