Detailed information for compound 566699

Basic information

Technical information
  • TDR Targets ID: 566699
  • Name: [(2R,3Z,5S,8R,9S,10S,13S,14S,17S)-2-chloro-10 ,13-dimethyl-3-(4-nitrophenoxy)imino-1,2,4,5, 6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclo penta[a]phenanthren-17-yl] acetate
  • MW: 503.03 | Formula: C27H35ClN2O5
  • H donors: 0 H acceptors: 3 LogP: 7.04 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)O[C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)C[C@@H](Cl)/C(=N\Oc1ccc(cc1)[N+](=O)[O-])/C2
  • InChi: 1S/C27H35ClN2O5/c1-16(31)34-25-11-10-21-20-9-4-17-14-24(29-35-19-7-5-18(6-8-19)30(32)33)23(28)15-27(17,3)22(20)12-13-26(21,25)2/h5-8,17,20-23,25H,4,9-15H2,1-3H3/b29-24-/t17-,20-,21-,22-,23+,25-,26-,27-/m0/s1
  • InChiKey: NNFGKFKPLQYECP-BYXNGVTISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • acetic acid [(2R,3Z,5S,8R,9S,10S,13S,14S,17S)-2-chloro-10,13-dimethyl-3-(4-nitrophenoxy)imino-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl] ester
  • [(2R,3Z,5S,8R,9S,10S,13S,14S,17S)-2-chloro-10,13-dimethyl-3-(4-nitrophenoxy)imino-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl] ethanoate
  • acetic acid [(2R,3Z,5S,8R,9S,10S,13S,14S,17S)-2-chloro-10,13-dimethyl-3-(4-nitrophenyl)oximino-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl] ester
  • nisterime acetate
  • ORF-9326
  • D05174
  • Nisterime acetate (USAN)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis GPCR, family 2 0.0048 0.033 0.0335
Loa Loa (eye worm) hypothetical protein 0.0037 0.0214 0.0217
Brugia malayi Cytochrome P450 family protein 0.0027 0.0118 0.012
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0312 0.3015 0.3065
Mycobacterium ulcerans beta-lactamase 0.0037 0.0214 1
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0241 0.0245
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.015 0.0153
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0025 0.0627
Echinococcus granulosus expressed protein 0.0017 0.0013 0.0013
Echinococcus granulosus dnaJ subfamily B 0.0843 0.8435 0.8574
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0508 0.0517
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0214 0.0217
Brugia malayi Protein kinase domain containing protein 0.098 0.9838 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.036 0.0365
Schistosoma mansoni hypothetical protein 0.0048 0.033 0.033
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0508 0.0517
Loa Loa (eye worm) hypothetical protein 0.0063 0.0483 0.0491
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0013 0.5
Mycobacterium tuberculosis Conserved protein 0.0037 0.0214 0.0903
Loa Loa (eye worm) Smad1 0.0016 0.0004 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.015 0.0153
Mycobacterium tuberculosis Conserved protein 0.0037 0.0214 0.0903
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0004 0.0004
Brugia malayi Cytochrome P450 family protein 0.0018 0.0025 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0025 0.0057
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.098 0.9838 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0993 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0025 0.0627
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0214 0.0214
Brugia malayi Pre-SET motif family protein 0.0031 0.015 0.0153
Brugia malayi Cytochrome P450 family protein 0.0058 0.0429 0.0436
Loa Loa (eye worm) hypothetical protein 0.0312 0.3015 0.3065
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.0517 0.0526
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.1129 0.1129
Schistosoma mansoni cpg binding protein 0.0063 0.0476 0.0476
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0025 0.0627
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0207 0.1953 0.1985
Loa Loa (eye worm) cytochrome P450 0.0018 0.0025 0.0026
Schistosoma mansoni transient receptor potential channel 4 0.0101 0.0865 0.0865
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0025 0.0627
Echinococcus multilocularis dnaJ subfamily B 0.0843 0.8435 0.8574
Schistosoma mansoni hypothetical protein 0.0176 0.1631 0.1631
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2224 1
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0036 0.0036
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0031 0.015 0.0153
Schistosoma mansoni transient receptor potential channel 0.0067 0.0517 0.0517
Entamoeba histolytica hypothetical protein 0.0074 0.0594 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0214 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0025 0.0057
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0466 0.0474
Echinococcus granulosus peregrin 0.003 0.0142 0.0145
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0048 0.033 0.033
Echinococcus multilocularis geminin 0.0176 0.1631 0.1658
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0004
Schistosoma mansoni jumonji domain containing protein 0.0078 0.063 0.063
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.1392 0.1415
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0118 0.012
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0004 0.0004
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0429 0.0436
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0025 0.0627
Schistosoma mansoni ferritin 0.0017 0.0013 0.0013
Trichomonas vaginalis ferritin, putative 0.0017 0.0013 0.0057
Schistosoma mansoni hypothetical protein 0.0176 0.1631 0.1631
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0214 1
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0594 0.0594
Onchocerca volvulus 0.0037 0.0214 0.0961
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0118 0.4919
Echinococcus granulosus tar DNA binding protein 0.0066 0.0508 0.0517
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0508 0.0508
Brugia malayi Transient-receptor-potential like protein 0.0037 0.022 0.0224
Schistosoma mansoni hypothetical protein 0.0074 0.0594 0.0594
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0025 0.0057
Schistosoma mansoni hypothetical protein 0.0843 0.8435 0.8435
Schistosoma mansoni apoferritin-2 0.0017 0.0013 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0025 0.0057
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0037 0.022 0.0224
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0118 0.4919
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0025 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0025 0.0057
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0025 0.0627
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0036 0.0036
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1936 0.1968
Brugia malayi CXXC zinc finger family protein 0.0059 0.0442 0.0449
Schistosoma mansoni Smad4 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0025 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0508 0.0508
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0025 0.0057
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0142 0.1209
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0186 0.0189
Brugia malayi Cytochrome P450 family protein 0.0027 0.0118 0.012
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.0517 0.0526
Brugia malayi PHD-finger family protein 0.003 0.0142 0.0145
Echinococcus granulosus transient receptor potential gamma protein 0.0101 0.0865 0.0879
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0025 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0025 0.0057
Loa Loa (eye worm) hypothetical protein 0.098 0.9838 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0004
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.228 0.2317
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0594 0.0604
Echinococcus multilocularis microtubule associated protein 2 0.0706 0.704 0.7155
Brugia malayi TAR-binding protein 0.0066 0.0508 0.0517
Echinococcus granulosus GPCR family 2 0.0048 0.033 0.0335
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0214 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0004 0.0004
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0025 0.0627
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0214 0.0961
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0142 0.0145
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0207 0.1953 0.1985
Echinococcus granulosus Smad4 0.0016 0.0004 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0508 0.0517
Schistosoma mansoni transient receptor potential channel 0.0101 0.0865 0.0865
Mycobacterium ulcerans lipase LipD 0.0037 0.0214 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0214 0.0217
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0025 0.0057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0214 0.0217
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0025 0.0627
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0142 0.0145
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.033 0.0335
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0036 0.0036
Onchocerca volvulus 0.0037 0.0214 0.0961
Schistosoma mansoni microtubule-associated protein tau 0.0706 0.704 0.704
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0142 0.0145
Onchocerca volvulus 0.0031 0.015 0.0675
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0025 0.0057
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0214 0.0217
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0214 0.0214
Echinococcus multilocularis smad 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0214 0.0903
Brugia malayi Latrophilin receptor protein 2 0.0048 0.033 0.0335
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.022 0.0224
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0214 0.0903
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0025 0.0627
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.228 0.2317
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0025 0.0627
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.1392 0.1415
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0004 0.0004
Brugia malayi Pre-SET motif family protein 0.0206 0.1936 0.1968
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.033 0.0335
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0508 0.0508
Mycobacterium tuberculosis Conserved protein 0.0037 0.0214 0.0903
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0025 0.0026
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0025 0.0627
Onchocerca volvulus 0.0234 0.2224 1
Schistosoma mansoni apoferritin-2 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0037 0.0214 0.0217
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0025 0.0627
Brugia malayi RNA binding protein 0.0066 0.0508 0.0517
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0508 0.0508
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0214 0.0903
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0025 0.0057
Schistosoma mansoni ferritin 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.098 0.9838 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.098 0.9838 1
Plasmodium vivax SET domain protein, putative 0.0031 0.015 0.112
Entamoeba histolytica hypothetical protein 0.0074 0.0594 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0025 0.0057
Brugia malayi jmjC domain containing protein 0.0039 0.0241 0.0245
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0025 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0037 0.0214 0.0217
Echinococcus multilocularis peregrin 0.003 0.0142 0.0145
Loa Loa (eye worm) hypothetical protein 0.0101 0.0865 0.0879
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0834 0.0848
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.015 0.015
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0214 1
Leishmania major cytochrome p450-like protein 0.0027 0.0118 0.4919
Brugia malayi Bromodomain containing protein 0.003 0.0142 0.0145
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0241 0.0241
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0214 0.0903
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.015 0.0153
Loa Loa (eye worm) hypothetical protein 0.003 0.0142 0.0145
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0025 0.0627
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0118 0.4919
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.015 0.015
Echinococcus granulosus transient receptor potential ion channel A 0.0097 0.0831 0.0845
Schistosoma mansoni ferritin 0.0017 0.0013 0.0013
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0261 0.0266
Schistosoma mansoni ferritin light chain 0.0017 0.0013 0.0013
Echinococcus multilocularis transient receptor potential gamma protein 0.0101 0.0865 0.0879
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0013 0.5
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0025 0.0057
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.015 0.1292
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0025 0.0627
Schistosoma mansoni hypothetical protein 0.0018 0.0025 0.0025
Onchocerca volvulus Alhambra homolog 0.003 0.0142 0.0639
Echinococcus granulosus microtubule associated protein 2 0.0706 0.704 0.7155
Schistosoma mansoni smad 0.0016 0.0004 0.0004
Echinococcus granulosus smad 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0214 0.0903
Leishmania major hypothetical protein, conserved 0.0037 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0214 0.0217
Loa Loa (eye worm) beta-lactamase 0.0037 0.0214 0.0217
Brugia malayi beta-lactamase family protein 0.0037 0.0214 0.0217
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0214 0.0961
Echinococcus multilocularis cpg binding protein 0.0063 0.0476 0.0484
Schistosoma mansoni ferritin light chain 0.0017 0.0013 0.0013
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0442 0.0449
Loa Loa (eye worm) TKL/MLK/LZK protein kinase 0.098 0.9838 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0508 0.0517
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0025 0.0627
Schistosoma mansoni hypothetical protein 0.0104 0.0901 0.0901
Schistosoma mansoni hypothetical protein 0.003 0.0142 0.0142
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0074 0.0594 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0025 0.0627
Schistosoma mansoni cytochrome P450 0.0018 0.0025 0.0025
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0214 0.0903
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.033 0.0335
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0214 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0206 0.021
Echinococcus multilocularis transient receptor potential ion channel A 0.0097 0.0831 0.0845
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0142 0.1209
Echinococcus multilocularis Smad4 0.0016 0.0004 0.0004
Onchocerca volvulus 0.0037 0.0214 0.0961
Echinococcus multilocularis 0.0018 0.0025 0.0026
Brugia malayi beta-lactamase 0.0037 0.0214 0.0217
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.0517 0.0526
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0025 0.0627
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0214 0.0217
Schistosoma mansoni transient receptor potential channel 0.0067 0.0517 0.0517
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0025 0.0057
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0004
Echinococcus granulosus geminin 0.0176 0.1631 0.1658
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0118 0.012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.2238 1
Loa Loa (eye worm) RNA binding protein 0.0066 0.0508 0.0517
Mycobacterium ulcerans hypothetical protein 0.0037 0.0214 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.022 0.0224
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0004 0.0004
Echinococcus granulosus ferritin 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0037 0.0214 0.0217
Mycobacterium leprae Probable lipase LipE 0.0037 0.0214 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0025 0.0057
Giardia lamblia PHD finger protein 15 0.003 0.0142 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0241 0.0245
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0142 0.0142
Brugia malayi jmjC domain containing protein 0.0098 0.0834 0.0848
Mycobacterium leprae putative cytochrome p450 0.0018 0.0025 0.0627
Echinococcus multilocularis expressed protein 0.0017 0.0013 0.0013
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0133 0.0135
Echinococcus granulosus cpg binding protein 0.0063 0.0476 0.0484
Toxoplasma gondii ABC1 family protein 0.0037 0.0214 0.1948
Plasmodium falciparum phd finger protein, putative 0.003 0.0142 0.5
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0004 0.0004
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0118 0.012
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0261 0.0266
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0126 0.0128
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0214 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0594 0.0604
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0214 0.0961
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0901 0.0915
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0214 1
Onchocerca volvulus 0.0059 0.0442 0.1985
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0025 0.0057
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.0517 0.0526
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0025 0.0627
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0025 0.0627
Loa Loa (eye worm) hypothetical protein 0.0048 0.033 0.0335
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0214 0.0961
Brugia malayi beta-lactamase family protein 0.0037 0.0214 0.0217
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0025 0.0627
Brugia malayi Smad1 0.0016 0.0004 0.0004
Schistosoma mansoni cpg binding protein 0.0059 0.0442 0.0442
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.015 0.015
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0118 0.5238
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0214 0.0903
Schistosoma mansoni hypothetical protein 0.0048 0.033 0.033
Schistosoma mansoni hypothetical protein 0.0048 0.033 0.033
Trichomonas vaginalis esterase, putative 0.0037 0.0214 0.0961
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.033 0.0335
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0214 0.0961
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0004
Echinococcus multilocularis ferritin 0.0017 0.0013 0.0013
Brugia malayi hypothetical protein 0.0074 0.0594 0.0604
Entamoeba histolytica hypothetical protein 0.0074 0.0594 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0025 0.0057
Brugia malayi cytochrome P450 0.0018 0.0025 0.0026
Schistosoma mansoni cpg binding protein 0.0063 0.0476 0.0476
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0834 0.0848
Brugia malayi MH2 domain containing protein 0.0239 0.228 0.2317
Schistosoma mansoni ferritin 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0104 0.0901 0.0915
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0025 0.0627

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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