Detailed information for compound 566700

Basic information

Technical information
  • TDR Targets ID: 566700
  • Name: [2-chloro-10,13-dimethyl-3-(4-nitrophenoxy)im ino-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetrade cahydrocyclopenta[a]phenanthren-17-yl] acetat e
  • MW: 503.03 | Formula: C27H35ClN2O5
  • H donors: 0 H acceptors: 3 LogP: 7.04 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)OC1CCC2C1(C)CCC1C2CCC2C1(C)CC(Cl)C(=NOc1ccc(cc1)[N+](=O)[O-])C2
  • InChi: 1S/C27H35ClN2O5/c1-16(31)34-25-11-10-21-20-9-4-17-14-24(29-35-19-7-5-18(6-8-19)30(32)33)23(28)15-27(17,3)22(20)12-13-26(21,25)2/h5-8,17,20-23,25H,4,9-15H2,1-3H3
  • InChiKey: NNFGKFKPLQYECP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • acetic acid [2-chloro-10,13-dimethyl-3-(4-nitrophenoxy)imino-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl] ester
  • [2-chloro-10,13-dimethyl-3-(4-nitrophenoxy)imino-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl] ethanoate
  • acetic acid [2-chloro-10,13-dimethyl-3-(4-nitrophenyl)oximino-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl] ester
  • nisterime acetate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0059 0.0442 0.0442
Brugia malayi beta-lactamase 0.0037 0.0214 0.0217
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0025 0.0057
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0483 0.0491
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0118 0.012
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0834 0.0848
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0098 0.0098
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0025 0.0057
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0214 0.0961
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0214 0.0961
Leishmania major hypothetical protein, conserved 0.0037 0.0214 1
Schistosoma mansoni cpg binding protein 0.0063 0.0476 0.0476
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0025 0.0627
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0508 0.0508
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0025 0.0627
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.022 0.0224
Schistosoma mansoni Smad4 0.0016 0.0004 0.0004
Brugia malayi Bromodomain containing protein 0.003 0.0142 0.0145
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0004
Loa Loa (eye worm) Smad1 0.0016 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0214 0.0217
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0214 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0025 0.0627
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0508 0.0517
Brugia malayi Pre-SET motif family protein 0.0206 0.1936 0.1968
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0508 0.0508
Schistosoma mansoni hypothetical protein 0.0074 0.0594 0.0594
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0025 0.0057
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0207 0.1953 0.1985
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0025 0.0057
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0004 0.0004
Brugia malayi Transient-receptor-potential like protein 0.0037 0.022 0.0224
Loa Loa (eye worm) TKL/MLK/LZK protein kinase 0.098 0.9838 1
Trichomonas vaginalis ferritin, putative 0.0017 0.0013 0.0057
Entamoeba histolytica hypothetical protein 0.0074 0.0594 1
Loa Loa (eye worm) beta-lactamase 0.0037 0.0214 0.0217
Brugia malayi Smad1 0.0016 0.0004 0.0004
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2224 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.2238 1
Brugia malayi cytochrome P450 0.0018 0.0025 0.0026
Echinococcus multilocularis microtubule associated protein 2 0.0706 0.704 0.7155
Loa Loa (eye worm) hypothetical protein 0.0037 0.022 0.0224
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0036 0.0036
Echinococcus granulosus Smad4 0.0016 0.0004 0.0004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.033 0.0335
Echinococcus multilocularis geminin 0.0176 0.1631 0.1658
Brugia malayi Cytochrome P450 family protein 0.0027 0.0118 0.012
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0594 0.0594
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0025 0.0057
Brugia malayi Pre-SET motif family protein 0.0031 0.015 0.0153
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.015 0.1292
Giardia lamblia PHD finger protein 15 0.003 0.0142 1
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0118 0.4919
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0025 0.0627
Toxoplasma gondii ABC1 family protein 0.0037 0.0214 0.1948
Onchocerca volvulus 0.0037 0.0214 0.0961
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.015 0.015
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0025 0.0627
Echinococcus multilocularis Smad4 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0025 0.0057
Echinococcus granulosus smad 0.0016 0.0004 0.0004
Schistosoma mansoni smad 0.0016 0.0004 0.0004
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.022 0.0224
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0261 0.0266
Brugia malayi RNA binding protein 0.0066 0.0508 0.0517
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0142 0.0145
Echinococcus granulosus ferritin 0.0017 0.0013 0.0013
Echinococcus multilocularis GPCR, family 2 0.0048 0.033 0.0335
Onchocerca volvulus 0.0031 0.015 0.0675
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0429 0.0436
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.0517 0.0526
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0126 0.0128
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0214 0.0217
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0004 0.0004
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.0517 0.0526
Echinococcus granulosus peregrin 0.003 0.0142 0.0145
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0025 0.0057
Brugia malayi PHD-finger family protein 0.003 0.0142 0.0145
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0025 0.0627
Schistosoma mansoni hypothetical protein 0.0048 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0048 0.033 0.0335
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0312 0.3015 0.3065
Echinococcus granulosus geminin 0.0176 0.1631 0.1658
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0993 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0214 0.0217
Schistosoma mansoni ferritin 0.0017 0.0013 0.0013
Schistosoma mansoni transient receptor potential channel 0.0067 0.0517 0.0517
Schistosoma mansoni microtubule-associated protein tau 0.0706 0.704 0.704
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0142 0.1209
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0118 0.4919
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0214 0.0217
Brugia malayi jmjC domain containing protein 0.0098 0.0834 0.0848
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.015 0.0153
Loa Loa (eye worm) hypothetical protein 0.0312 0.3015 0.3065
Mycobacterium ulcerans beta-lactamase 0.0037 0.0214 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0142 0.0145
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0133 0.0135
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0025 0.0627
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0214 0.0903
Echinococcus granulosus microtubule associated protein 2 0.0706 0.704 0.7155
Onchocerca volvulus 0.0037 0.0214 0.0961
Schistosoma mansoni ferritin 0.0017 0.0013 0.0013
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0142 0.0145
Onchocerca volvulus 0.0037 0.0214 0.0961
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0214 0.0903
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.015 0.0153
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0214 0.0961
Loa Loa (eye worm) hypothetical protein 0.0101 0.0865 0.0879
Mycobacterium tuberculosis Conserved protein 0.0037 0.0214 0.0903
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0214 0.0903
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0508 0.0517
Brugia malayi Cytochrome P450 family protein 0.0027 0.0118 0.012
Plasmodium vivax SET domain protein, putative 0.0031 0.015 0.112
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0214 0.0214
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0261 0.0266
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.033 0.0335
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0025 0.0057
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0025 0.0627
Entamoeba histolytica hypothetical protein 0.0074 0.0594 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0118 0.012
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0214 1
Brugia malayi CXXC zinc finger family protein 0.0059 0.0442 0.0449
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0025 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0025 0.0057
Echinococcus granulosus tar DNA binding protein 0.0066 0.0508 0.0517
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0025 0.0627
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0142 0.1209
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0594 0.0604
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0036 0.0036
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.1392 0.1415
Loa Loa (eye worm) hypothetical protein 0.0031 0.015 0.0153
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0214 0.0903
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0214 0.0903
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0594 0.0604
Loa Loa (eye worm) hypothetical protein 0.003 0.0142 0.0145
Loa Loa (eye worm) hypothetical protein 0.0034 0.0186 0.0189
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0013 0.5
Echinococcus granulosus cpg binding protein 0.0063 0.0476 0.0484
Brugia malayi Cytochrome P450 family protein 0.0018 0.0025 0.0026
Brugia malayi jmjC domain containing protein 0.0039 0.0241 0.0245
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0025 0.0057
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0214 0.0961
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.1392 0.1415
Plasmodium falciparum phd finger protein, putative 0.003 0.0142 0.5
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0025 0.0057
Onchocerca volvulus Alhambra homolog 0.003 0.0142 0.0639
Schistosoma mansoni hypothetical protein 0.0048 0.033 0.033
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0025 0.0627
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0025 0.0057
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0013 0.5
Loa Loa (eye worm) hypothetical protein 0.0104 0.0901 0.0915
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0004
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0241 0.0245
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0214 1
Schistosoma mansoni cytochrome P450 0.0018 0.0025 0.0025
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0025 0.0627
Loa Loa (eye worm) hypothetical protein 0.098 0.9838 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0004 0.0004
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.0517 0.0526
Schistosoma mansoni transient receptor potential channel 0.0067 0.0517 0.0517
Loa Loa (eye worm) RNA binding protein 0.0066 0.0508 0.0517
Mycobacterium ulcerans lipase LipD 0.0037 0.0214 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.015 0.0153
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0004
Schistosoma mansoni jumonji domain containing protein 0.0078 0.063 0.063
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0214 0.0217
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0025 0.0057
Onchocerca volvulus 0.0234 0.2224 1
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0508 0.0517
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0207 0.1953 0.1985
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0214 0.0217
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0834 0.0848
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0025 0.0627
Schistosoma mansoni transient receptor potential channel 4 0.0101 0.0865 0.0865
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0508 0.0508
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.0517 0.0526
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0004
Echinococcus multilocularis cpg binding protein 0.0063 0.0476 0.0484
Schistosoma mansoni ferritin 0.0017 0.0013 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0214 1
Schistosoma mansoni hypothetical protein 0.0048 0.033 0.033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.015 0.015
Schistosoma mansoni hypothetical protein 0.0018 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0176 0.1631 0.1631
Schistosoma mansoni apoferritin-2 0.0017 0.0013 0.0013
Schistosoma mansoni apoferritin-2 0.0017 0.0013 0.0013
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0118 0.012
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0118 0.5238
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0025 0.0627
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0025 0.0627
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0025 0.0057
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0214 0.0217
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.015 0.015
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0214 0.0961
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0004 0.0004
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0004
Echinococcus multilocularis ferritin 0.0017 0.0013 0.0013
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0004 0.0004
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0025 0.0627
Schistosoma mansoni ferritin 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.098 0.9838 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0508 0.0508
Echinococcus granulosus dnaJ subfamily B 0.0843 0.8435 0.8574
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0025 0.0627
Brugia malayi Protein kinase domain containing protein 0.098 0.9838 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.015 0.015
Brugia malayi MH2 domain containing protein 0.0239 0.228 0.2317
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0025 0.0627
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0241 0.0241
Echinococcus multilocularis dnaJ subfamily B 0.0843 0.8435 0.8574
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0025 0.0627
Loa Loa (eye worm) hypothetical protein 0.0037 0.0214 0.0217
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0025 0.0057
Loa Loa (eye worm) hypothetical protein 0.0051 0.036 0.0365
Echinococcus multilocularis transient receptor potential ion channel A 0.0097 0.0831 0.0845
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.098 0.9838 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0101 0.0865 0.0879
Echinococcus granulosus transient receptor potential ion channel A 0.0097 0.0831 0.0845
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.098 0.9838 1
Schistosoma mansoni hypothetical protein 0.0104 0.0901 0.0901
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1936 0.1968
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.1129 0.1129
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0206 0.021
Schistosoma mansoni ferritin light chain 0.0017 0.0013 0.0013
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0025 0.0026
Schistosoma mansoni hypothetical protein 0.003 0.0142 0.0142
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0025 0.0627
Brugia malayi beta-lactamase family protein 0.0037 0.0214 0.0217
Mycobacterium tuberculosis Conserved protein 0.0037 0.0214 0.0903
Brugia malayi TAR-binding protein 0.0066 0.0508 0.0517
Trichomonas vaginalis esterase, putative 0.0037 0.0214 0.0961
Echinococcus multilocularis 0.0018 0.0025 0.0026
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0025 0.0627
Echinococcus granulosus GPCR family 2 0.0048 0.033 0.0335
Brugia malayi Latrophilin receptor protein 2 0.0048 0.033 0.0335
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0442 0.0449
Onchocerca volvulus 0.0059 0.0442 0.1985
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.033 0.0335
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0025 0.0057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0214 0.0217
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0241 0.0245
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0118 0.4919
Schistosoma mansoni hypothetical protein 0.0176 0.1631 0.1631
Schistosoma mansoni cpg binding protein 0.0063 0.0476 0.0476
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0025 0.0057
Brugia malayi Cytochrome P450 family protein 0.0058 0.0429 0.0436
Entamoeba histolytica hypothetical protein 0.0074 0.0594 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0214 0.0903
Brugia malayi beta-lactamase family protein 0.0037 0.0214 0.0217
Echinococcus multilocularis smad 0.0016 0.0004 0.0004
Schistosoma mansoni transient receptor potential channel 0.0101 0.0865 0.0865
Schistosoma mansoni ferritin light chain 0.0017 0.0013 0.0013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.033 0.0335
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0214 0.0214
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0241 0.0241
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0466 0.0474
Entamoeba histolytica hypothetical protein 0.0074 0.0594 1
Echinococcus multilocularis peregrin 0.003 0.0142 0.0145
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0025 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0025 0.0057
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0025 0.0627
Schistosoma mansoni hypothetical protein 0.0843 0.8435 0.8435
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.228 0.2317
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0036 0.0036
Mycobacterium leprae putative cytochrome p450 0.0018 0.0025 0.0627
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0508 0.0508
Brugia malayi hypothetical protein 0.0074 0.0594 0.0604
Echinococcus multilocularis expressed protein 0.0017 0.0013 0.0013
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0214 1
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0214 0.0903
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0901 0.0915
Loa Loa (eye worm) cytochrome P450 0.0018 0.0025 0.0026
Mycobacterium leprae Probable lipase LipE 0.0037 0.0214 1
Leishmania major cytochrome p450-like protein 0.0027 0.0118 0.4919
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.228 0.2317
Loa Loa (eye worm) hypothetical protein 0.0037 0.0214 0.0217
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0004 0.0004
Echinococcus granulosus transient receptor potential gamma protein 0.0101 0.0865 0.0879
Schistosoma mansoni hypothetical protein 0.0048 0.033 0.033
Mycobacterium tuberculosis Conserved protein 0.0037 0.0214 0.0903
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0142 0.0142
Echinococcus granulosus expressed protein 0.0017 0.0013 0.0013
Mycobacterium ulcerans hypothetical protein 0.0037 0.0214 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0508 0.0517

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.