Detailed information for compound 581197

Basic information

Technical information
  • TDR Targets ID: 581197
  • Name: (2S)-1-(3-sulfanylpropanoyl)-3,4-dihydro-2H-q uinoline-2-carboxylic acid
  • MW: 265.328 | Formula: C13H15NO3S
  • H donors: 1 H acceptors: 3 LogP: 1.52 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: SCCC(=O)N1[C@@H](CCc2c1cccc2)C(=O)O
  • InChi: 1S/C13H15NO3S/c15-12(7-8-18)14-10-4-2-1-3-9(10)5-6-11(14)13(16)17/h1-4,11,18H,5-8H2,(H,16,17)/t11-/m0/s1
  • InChiKey: YGYNTRGPFBSTAZ-NSHDSACASA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-1-(3-mercapto-1-oxopropyl)-3,4-dihydro-2H-quinoline-2-carboxylic acid
  • (2S)-1-(3-mercaptopropanoyl)-3,4-dihydro-2H-quinoline-2-carboxylic acid
  • EU 5031
  • 75494-01-8
  • 1,2,3,4-Tetrahydro-2 (3-mercapto-1-oxopropyl)-2-quinolinecarboxylic acid
  • 2-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-1-(3-mercapto-1-oxopropyl)-, (S)-
  • EU-5031

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone lysine methyltransferase setb 0.0152 0.0279 0.1274
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1206 0.241 1
Echinococcus granulosus fch and double sh3 domains protein 2 0.0019 0.001 0.0047
Giardia lamblia PHD finger protein 15 0.021 0.0395 0.1421
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.009 0.0317
Schistosoma mansoni tensin 0.002 0.0011 0.003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0361 0.0702 0.096
Brugia malayi cytokine inducible SH2-containing protein 5 0.002 0.0011 0.0009
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0023 0.0107
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0165 0.0754
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.002 0.0011 0.0054
Brugia malayi Variant SH3 domain containing protein 0.0019 0.001 0.0008
Brugia malayi Bromodomain containing protein 0.021 0.0395 0.0538
Loa Loa (eye worm) hypothetical protein 0.025 0.0476 0.2255
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0062 0.0283
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0031 0.0033 0.0158
Schistosoma mansoni eps8-related protein 0.0019 0.001 0.0026
Entamoeba histolytica hypothetical protein 0.0037 0.0046 0.0151
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0062 0.0283
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1206 0.241 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.002 0.0011 0.0052
Brugia malayi Protein kinase domain containing protein 0.0026 0.0023 0.0025
Echinococcus granulosus snurportin 1 0.0303 0.0583 0.2659
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0165 0.0754
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0095 0.0434
Echinococcus granulosus expressed conserved protein 0.002 0.0011 0.0052
Echinococcus multilocularis lysine specific demethylase 6a 0.0083 0.0139 0.0635
Toxoplasma gondii PHD-finger domain-containing protein 0.021 0.0395 0.1442
Schistosoma mansoni hypothetical protein 0.0042 0.0056 0.024
Schistosoma mansoni phd/f-box containing protein 0.0083 0.0139 0.0625
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.0583 0.2759
Loa Loa (eye worm) hypothetical protein 0.0152 0.0279 0.1322
Entamoeba histolytica Ran family GTPase 0.0021 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0361 0.0702 0.3322
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0095 0.0421
Echinococcus multilocularis dna polymerase kappa 0.002 0.0012 0.0053
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.0266 0.1214
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.1319 0.612
Schistosoma mansoni inositol monophosphatase 0.0039 0.005 0.0208
Brugia malayi Protein-tyrosine phosphatase containing protein 0.002 0.0011 0.0009
Toxoplasma gondii RNA-directed DNA polymerase 0.1355 0.271 1
Schistosoma mansoni hypothetical protein 0.002 0.0011 0.003
Echinococcus multilocularis tyrosine protein kinase shark 0.0026 0.0023 0.0103
Echinococcus multilocularis lysine specific demethylase 5A 0.0312 0.0601 0.2743
Loa Loa (eye worm) jmjC domain-containing protein 0.0083 0.0139 0.0658
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0054
Brugia malayi Myosin tail family protein 0.0019 0.001 0.0008
Brugia malayi RNA, U transporter 1 0.0081 0.0134 0.0178
Echinococcus granulosus nostrin 0.0019 0.001 0.0047
Echinococcus granulosus SH2 domain containing protein 7 0.002 0.0011 0.0052
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0045 0.0062 0.0266
Brugia malayi Variant SH3 domain containing protein 0.0019 0.001 0.0008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0062 0.0283
Trichomonas vaginalis set domain proteins, putative 0.1205 0.2408 0.999
Echinococcus granulosus dna polymerase eta 0.002 0.0012 0.0053
Echinococcus granulosus SH2 domain containing adapter protein F 0.002 0.0011 0.0052
Loa Loa (eye worm) jmjC domain-containing protein 0.0313 0.0604 0.2861
Schistosoma mansoni tensin-related 0.002 0.0011 0.003
Treponema pallidum fructose-bisphosphate aldolase 0.1206 0.241 0.5
Echinococcus multilocularis tensin 0.002 0.0011 0.0052
Schistosoma mansoni signal transduction protein lnk-related 0.002 0.0011 0.003
Brugia malayi hypothetical protein 0.0026 0.0023 0.0025
Echinococcus multilocularis c src tyrosine kinase 0.0045 0.0062 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.004 0.0124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0165 0.0754
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0152 0.0279 0.1274
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0039 0.0051 0.024
Plasmodium falciparum phd finger protein, putative 0.021 0.0395 0.1442
Echinococcus multilocularis PHD finger protein rhinoceros 0.021 0.0395 0.1803
Echinococcus granulosus phd:f box containing protein 0.0083 0.0139 0.0635
Echinococcus granulosus SH2 motif 0.002 0.0011 0.0052
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0019 0.001 0.0026
Echinococcus granulosus signal transduction protein lnk realted 0.002 0.0011 0.0052
Loa Loa (eye worm) hypothetical protein 0.0083 0.0139 0.0658
Entamoeba histolytica hypothetical protein 0.0037 0.0046 0.0151
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0019 0.001 0.0047
Giardia lamblia Fructose-bisphosphate aldolase 0.1206 0.241 0.8887
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0095 0.0727
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.0062 0.0283
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0076 0.0124 0.0566
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0013 0.0031
Entamoeba histolytica hypothetical protein 0.003 0.0032 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0054
Schistosoma mansoni jumonji/arid domain-containing protein 0.0313 0.0604 0.2792
Onchocerca volvulus 0.002 0.0011 0.0001
Brugia malayi MH2 domain containing protein 0.0115 0.0204 0.0275
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0012 0.0009
Echinococcus multilocularis suppressor of cytokine signaling 6 0.002 0.0011 0.0052
Echinococcus multilocularis intersectin 2 0.0019 0.001 0.0047
Echinococcus granulosus N chimaerin 0.002 0.0011 0.0052
Brugia malayi STAT protein, DNA binding domain containing protein 0.002 0.0011 0.0009
Echinococcus multilocularis Glycosyltransferase protein LARGE1 0.0058 0.0088 0.0403
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0152 0.0279 0.1278
Brugia malayi CXXC zinc finger family protein 0.0028 0.0028 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0152 0.0279 0.1278
Echinococcus granulosus intermediate filament protein 0.0027 0.0025 0.0112
Brugia malayi Tyrosine-protein kinase abl-1 0.0045 0.0062 0.0079
Schistosoma mansoni tyrosine kinase 0.0045 0.0062 0.0266
Echinococcus multilocularis peregrin 0.021 0.0395 0.1803
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0013 0.0063
Echinococcus multilocularis SH2 motif 0.002 0.0011 0.0052
Schistosoma mansoni inositol monophosphatase 0.0039 0.005 0.0208
Loa Loa (eye worm) latrophilin receptor protein 2 0.0114 0.0202 0.0957
Schistosoma mansoni hypothetical protein 0.0051 0.0074 0.0323
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0025 0.0117
Brugia malayi AT16019p 0.002 0.0012 0.001
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0081 0.0135 0.0606
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0749 0.1484 0.7029
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0041 0.0315
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0054
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0005 0.0022
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.0062 0.0283
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0054
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0589 0.1162 1
Trypanosoma brucei conserved protein 0.0019 0.001 0.002
Schistosoma mansoni hypothetical protein 0.0342 0.0663 0.3066
Toxoplasma gondii PHD-finger domain-containing protein 0.0069 0.011 0.0387
Onchocerca volvulus 0.0152 0.0279 0.0269
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0095 0.0421
Echinococcus multilocularis NCK adaptor protein 0.0039 0.0051 0.0231
Loa Loa (eye worm) hypothetical protein 0.021 0.0395 0.187
Echinococcus granulosus lamin 0.0027 0.0025 0.0112
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0028 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Loa Loa (eye worm) jmjC domain-containing protein 0.0083 0.0139 0.0658
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0056
Echinococcus granulosus Spectrin alpha actinin 0.0019 0.001 0.0047
Schistosoma mansoni hypothetical protein 0.0069 0.011 0.0488
Echinococcus granulosus tyrosine protein kinase Blk 0.0026 0.0023 0.0103
Echinococcus multilocularis GPCR, family 2 0.0114 0.0202 0.0923
Loa Loa (eye worm) jmjC domain-containing protein 0.0433 0.0846 0.4008
Schistosoma mansoni glycosyltransferase-related 0.0078 0.0129 0.0579
Leishmania major DNA polymerase eta, putative 0.002 0.0012 0.0025
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0012 0.0055
Schistosoma mansoni adapter molecule crk 0.0039 0.0051 0.0213
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.002 0.0011 0.0052
Echinococcus granulosus lysine specific demethylase 5A 0.0313 0.0604 0.2758
Schistosoma mansoni tensin 0.002 0.0011 0.003
Onchocerca volvulus 0.002 0.0011 0.0001
Brugia malayi hypothetical protein 0.025 0.0476 0.065
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0049
Onchocerca volvulus Alhambra homolog 0.021 0.0395 0.0385
Echinococcus granulosus intersectin 2 0.0019 0.001 0.0047
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.021 0.0395 0.1817
Brugia malayi Guanylate kinase family protein 0.0019 0.001 0.0008
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0019 0.001 0.0049
Onchocerca volvulus 0.0026 0.0023 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0012 0.0025
Brugia malayi Cation transporter family protein 0.0081 0.0135 0.0179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0165 0.0747
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0139 0.0625
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.005 0.0163
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0018 0.003
Echinococcus granulosus suppressor of cytokine signaling 6 0.002 0.0011 0.0052
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.005 0.0226
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0112
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0025
Echinococcus granulosus jumonji domain containing 1A 0.0083 0.0139 0.0635
Echinococcus multilocularis tensin 0.002 0.0011 0.0052
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0012 0.0025
Plasmodium falciparum JmjC domain-containing protein, putative 0.0083 0.0139 0.0496
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.007 0.0113 0.04
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0019 0.001 0.0047
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0018 0.0047
Onchocerca volvulus 0.002 0.0011 0.0001
Trichomonas vaginalis rotamase, putative 0.0034 0.004 0.0124
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0095 0.0727
Schistosoma mansoni hypothetical protein 0.021 0.0395 0.1817
Brugia malayi jmjC domain containing protein 0.0313 0.0604 0.0826
Trichomonas vaginalis ran, putative 0.0021 0.0013 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0012 0.0025
Schistosoma mansoni shc transforming protein 0.002 0.0011 0.003
Brugia malayi Protein kinase domain containing protein 0.0026 0.0023 0.0025
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0019 0.001 0.0026
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0076 0.0124 0.0566
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0054
Schistosoma mansoni growth factor receptor-bound protein 0.0039 0.0051 0.0213
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0114 0.0202 0.0923
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1206 0.241 1
Schistosoma mansoni lamin 0.0027 0.0025 0.0092
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0114 0.0202 0.0923
Echinococcus granulosus peregrin 0.021 0.0395 0.1803
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0013 0.006
Brugia malayi SH2 domain containing protein 0.002 0.0011 0.0009
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0013 0.006
Echinococcus granulosus tyrosine protein kinase Src42A 0.002 0.0011 0.0052
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0023 0.0107
Onchocerca volvulus 0.0081 0.0135 0.0125
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0026 0.0023 0.0103
Echinococcus granulosus tyrosine kinase 0.0026 0.0023 0.0103
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0046 0.0212
Onchocerca volvulus 0.0026 0.0023 0.0012
Brugia malayi F/Y-rich N-terminus family protein 0.0083 0.0138 0.0184
Schistosoma mansoni hypothetical protein 0.0042 0.0056 0.024
Schistosoma mansoni intermediate filament proteins 0.0027 0.0025 0.0092
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.002 0.0011 0.0001
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0026 0.0023 0.0103
Echinococcus granulosus tyrosine protein kinase Srms 0.0026 0.0023 0.0103
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1098 0.2191 1
Schistosoma mansoni hypothetical protein 0.0019 0.001 0.0026
Schistosoma mansoni hypothetical protein 0.0342 0.0663 0.3066
Loa Loa (eye worm) PHD-finger family protein 0.021 0.0395 0.187
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0054
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0023 0.0107
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0095 0.0727
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0019 0.001 0.0047
Echinococcus multilocularis tyrosine kinase 0.0026 0.0023 0.0103
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0022
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0083 0.0139 0.0496
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0023 0.0107
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0038 0.0124
Schistosoma mansoni tensin 0.002 0.0011 0.003
Echinococcus multilocularis protein patched 0.0044 0.006 0.0272
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0054
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0026 0.0023 0.0103
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0146 0.0267 0.1217
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0019 0.001 0.0047
Trypanosoma brucei telomerase reverse transcriptase 0.1355 0.271 1
Echinococcus granulosus lamin dm0 0.0027 0.0025 0.0112
Entamoeba histolytica protein kinase, putative 0.002 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0134
Brugia malayi Variant SH3 domain containing protein 0.0019 0.001 0.0008
Entamoeba histolytica hypothetical protein 0.0037 0.0046 0.0151
Echinococcus granulosus SHC transforming protein 3 0.002 0.0011 0.0052
Loa Loa (eye worm) hypothetical protein 0.0039 0.0051 0.024
Brugia malayi Tensin 0.002 0.0011 0.0009
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0069 0.011 0.0387
Schistosoma mansoni hypothetical protein 0.0247 0.047 0.2169
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0018 0.003
Schistosoma mansoni ran 0.0021 0.0013 0.0039
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0069 0.011 0.0387
Brugia malayi Protein kinase domain containing protein 0.0026 0.0023 0.0025
Entamoeba histolytica hypothetical protein 0.0037 0.0046 0.0151
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0114 0.0202 0.0923
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0158
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.0784 0.3577
Echinococcus multilocularis transfer RNA-Ala 0.0019 0.001 0.0047
Echinococcus multilocularis expressed conserved protein 0.0096 0.0165 0.0753
Echinococcus multilocularis dna polymerase eta 0.002 0.0012 0.0053
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.002 0.0011 0.0052
Brugia malayi AF-10 protein 0.0069 0.011 0.0144
Loa Loa (eye worm) guanylate kinase 0.0019 0.001 0.0049
Brugia malayi jmjC domain containing protein 0.0745 0.1476 0.2028
Onchocerca volvulus 0.0026 0.0023 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0023 0.0107
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.0062 0.0283
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0019 0.001 0.0049
Onchocerca volvulus 0.002 0.0011 0.0001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0095 0.0781
Brugia malayi Pre-SET motif family protein 0.1059 0.2112 0.2904
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0177 0.0238
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0026 0.0023 0.0051
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0095 0.0334
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0165 0.0782
Echinococcus multilocularis JmjC domain containing protein 4 0.0083 0.0139 0.0635
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.0062 0.0283
Echinococcus granulosus importin subunit beta 1 0.0028 0.0028 0.0129
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0023 0.0107
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.002 0.0011 0.0052
Brugia malayi Protein kinase domain containing protein 0.0026 0.0023 0.0025
Brugia malayi SH2 domain containing protein 0.002 0.0011 0.0009
Brugia malayi Variant SH3 domain containing protein 0.0019 0.001 0.0008
Brugia malayi SH2 domain containing protein 0.002 0.0011 0.0009
Schistosoma mansoni run and tbc1 domain containing 0.0019 0.001 0.0026
Brugia malayi SH3 domain containing protein 0.0019 0.001 0.0008
Brugia malayi Latrophilin receptor protein 2 0.0114 0.0202 0.0272
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0074 0.0095
Plasmodium vivax hypothetical protein, conserved 0.007 0.0113 0.04
Echinococcus granulosus geminin 0.0342 0.0663 0.3026
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0046 0.0194
Schistosoma mansoni jumonji/arid domain-containing protein 0.0313 0.0604 0.2792
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.002 0.0011 0.0001
Schistosoma mansoni dynamin-associated protein 0.0019 0.001 0.0026
Brugia malayi SH2 domain containing protein 0.0026 0.0023 0.0025
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0013 0.0031
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0152 0.0279 0.1014
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0745 0.1476 0.6738
Loa Loa (eye worm) hypothetical protein 0.0247 0.047 0.2228
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1098 0.2191 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0095 0.0334
Brugia malayi SH2 domain containing protein 0.002 0.0011 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1206 0.241 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0177 0.081
Echinococcus multilocularis conserved hypothetical protein 0.0058 0.0088 0.0403
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0589 0.1162 1
Echinococcus multilocularis Spectrin alpha actinin 0.0019 0.001 0.0047
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0051 0.0063
Schistosoma mansoni hypothetical protein 0.0114 0.0202 0.0919
Loa Loa (eye worm) glycosyl transferase family 8 protein 0.0078 0.0129 0.0611
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1206 0.241 1
Brugia malayi SH2 domain containing protein 0.002 0.0011 0.0009
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0038 0.0124
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0013 0.0031
Brugia malayi CHE-14 protein 0.0044 0.006 0.0076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0165 0.0754
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0038 0.0124
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.002 0.0011 0.0052
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0054
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1355 0.271 1
Toxoplasma gondii PHD-finger domain-containing protein 0.021 0.0395 0.1442
Trichomonas vaginalis rotamase, putative 0.0033 0.0038 0.0117
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0019 0.001 0.002
Echinococcus multilocularis 0.002 0.0011 0.0052
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0038 0.0124
Brugia malayi Glycosyl transferase family 8 protein 0.0078 0.0129 0.0171
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0012 0.0058
Echinococcus multilocularis snurportin 1 0.0303 0.0583 0.2659
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0013 0.0006
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0083 0.0139 0.0496
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Echinococcus multilocularis phd:f box containing protein 0.0083 0.0139 0.0635
Echinococcus granulosus NCK adaptor protein 0.0039 0.0051 0.0231
Schistosoma mansoni jumonji domain containing protein 0.0604 0.1191 0.5525
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0012 0.0053
Schistosoma mansoni rotamase 0.0034 0.004 0.0164
Echinococcus multilocularis SH2 motif 0.002 0.0011 0.0052
Brugia malayi Variant SH3 domain containing protein 0.0019 0.001 0.0008
Echinococcus multilocularis SH2 motif 0.002 0.0011 0.0052
Brugia malayi PHD-finger family protein 0.021 0.0395 0.0538
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.006 0.0272
Plasmodium vivax JmjC domain containing protein 0.0083 0.0139 0.0496
Loa Loa (eye worm) RhoGAP domain-containing protein 0.002 0.0011 0.0054
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1206 0.241 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0012 0.0025
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.005 0.0163
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0081 0.0135 0.0607
Echinococcus granulosus Protein patched homolog 1 0.0044 0.006 0.0272
Schistosoma mansoni hypothetical protein 0.0114 0.0202 0.0919
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.005 0.0165
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0023 0.0107
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0012 0.0009
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0095 0.0434
Echinococcus granulosus hypothetical protein 0.002 0.0011 0.0052
Schistosoma mansoni growth factor receptor-bound protein 0.0039 0.0051 0.0213
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.0062 0.0283
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0081 0.0135 0.0606
Echinococcus multilocularis tyrosine protein kinase Srms 0.0026 0.0023 0.0103
Echinococcus granulosus GPCR family 2 0.0114 0.0202 0.0923
Schistosoma mansoni tyrosine-protein kinase zap-70 0.002 0.0011 0.003
Echinococcus granulosus JmjC domain containing protein 4 0.0083 0.0139 0.0635
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0012 0.0025
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.002 0.0011 0.0052
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0114 0.0202 0.0272
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.005 0.0163
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.006 0.0272
Echinococcus multilocularis tyrosine protein kinase Abl 0.0045 0.0062 0.0283
Schistosoma mansoni cpg binding protein 0.0028 0.0028 0.0109
Schistosoma mansoni suppressor of cytokine signaling 0.002 0.0011 0.003
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0025
Echinococcus granulosus microtubule associated protein 2 0.0667 0.1319 0.6018
Loa Loa (eye worm) SH2 domain-containing protein 0.002 0.0011 0.0054
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0051 0.0063
Echinococcus granulosus expressed conserved protein 0.0096 0.0165 0.0753
Leishmania major telomerase reverse transcriptase, putative 0.1355 0.271 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0045 0.0062 0.0283
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0049
Loa Loa (eye worm) inositol-1 0.0039 0.005 0.0235
Schistosoma mansoni hypothetical protein 0.0114 0.0202 0.0919
Schistosoma mansoni cpg binding protein 0.003 0.0031 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.001 0.002
Schistosoma mansoni protein phosphatase 2C 0.0083 0.0139 0.0625
Loa Loa (eye worm) TK protein kinase 0.0026 0.0023 0.0107
Schistosoma mansoni hypothetical protein 0.0303 0.0583 0.2692
Echinococcus multilocularis expressed protein 0.0019 0.001 0.0047
Brugia malayi Importin beta-1 subunit 0.0028 0.0028 0.0032
Loa Loa (eye worm) p53BP2 0.0019 0.001 0.0049
Schistosoma mansoni tyrosine kinase 0.0045 0.0062 0.0266
Loa Loa (eye worm) hypothetical protein 0.0081 0.0135 0.0638
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0062 0.0283
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.003 0.0032 0.0147
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0083 0.0139 0.0496
Echinococcus granulosus glycosyltransferase protein LARGE2 0.0076 0.0124 0.0566
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.001 0.002
Schistosoma mansoni C-fyn 0.0019 0.001 0.0026
Plasmodium falciparum telomerase reverse transcriptase 0.1355 0.271 1
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0023 0.0107
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0012 0.0005
Loa Loa (eye worm) thyroid receptor interactor 0.0019 0.001 0.0049
Brugia malayi jmjC domain containing protein 0.0083 0.0139 0.0185
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0046 0.0212
Echinococcus granulosus cpg binding protein 0.003 0.0031 0.0143
Echinococcus granulosus tyrosine kinase 0.0026 0.0023 0.0103
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0062 0.0283
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0023 0.0107
Onchocerca volvulus 0.002 0.0011 0.0001
Echinococcus multilocularis geminin 0.0342 0.0663 0.3026
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.006 0.0282
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0026 0.0023 0.0103
Loa Loa (eye worm) SRC-1 0.0045 0.0062 0.0293
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.002 0.0011 0.0052
Echinococcus granulosus jumonji domain containing protein 0.0292 0.0561 0.2561
Brugia malayi Spectrin alpha chain 0.0019 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0049
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1355 0.271 1
Echinococcus multilocularis lamin 0.0027 0.0025 0.0112
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.005 0.0165
Echinococcus granulosus tyrosine protein kinase ABL1 0.0026 0.0023 0.0103
Plasmodium vivax hypothetical protein, conserved 0.021 0.0395 0.1442
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0049
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0033 0.0039
Schistosoma mansoni dreadlocks/dock 0.0019 0.001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0049
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0083 0.0139 0.0625
Brugia malayi Angiotensin-converting enzyme family protein 0.0749 0.1484 0.2039
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0018 0.003
Loa Loa (eye worm) SH2 domain-containing protein 0.002 0.0011 0.0054
Brugia malayi Variant SH3 domain containing protein 0.0019 0.001 0.0008
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.003 0.0032 0.0128
Brugia malayi Variant SH3 domain containing protein 0.002 0.0011 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0012 0.0025
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0177 0.081
Onchocerca volvulus 0.0026 0.0023 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0054
Schistosoma mansoni SH2A 0.002 0.0011 0.003
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.005 0.0165
Loa Loa (eye worm) hypothetical protein 0.0054 0.008 0.0377
Schistosoma mansoni suppressor of cytokine signaling 0.002 0.0011 0.003
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0025 0.0117
Echinococcus granulosus growth factor receptor bound protein 2 0.0039 0.0051 0.0231
Echinococcus multilocularis musashi 0.0027 0.0025 0.0112
Schistosoma mansoni hypothetical protein 0.0037 0.0046 0.0194
Entamoeba histolytica SH2-protein kinase domain containing protein 0.002 0.0011 0.0004
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.0476 0.2173
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0589 0.1162 1
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0076 0.0124 0.0566
Schistosoma mansoni hypothetical protein 0.0042 0.0056 0.024
Echinococcus multilocularis jumonji domain containing protein 0.0292 0.0561 0.2561
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.0266 0.1214
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0152 0.0279 0.1278
Schistosoma mansoni hypothetical protein 0.0402 0.0784 0.3628
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0049
Brugia malayi latrophilin 2 splice variant baaae 0.0247 0.047 0.0642
Brugia malayi Pre-SET motif family protein 0.0152 0.0279 0.0378
Echinococcus granulosus lysine specific demethylase 6a 0.0083 0.0139 0.0635
Echinococcus multilocularis protein dispatched 1 0.005 0.0072 0.0329
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.0062 0.0283
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.005 0.0163
Schistosoma mansoni hypothetical protein 0.002 0.0011 0.003
Brugia malayi Inositol-1 0.0039 0.005 0.0062
Echinococcus multilocularis tyrosine protein kinase Blk 0.0026 0.0023 0.0103
Schistosoma mansoni survival motor neuron protein 0.0051 0.0074 0.0323
Leishmania major importin beta-1 subunit, putative 0.0023 0.0018 0.0047
Loa Loa (eye worm) hypothetical protein 0.0102 0.0177 0.084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0165 0.0747
Echinococcus multilocularis N chimaerin 0.002 0.0011 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1206 0.241 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0745 0.1476 0.6738
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0204 0.0967
Echinococcus granulosus dna polymerase kappa 0.002 0.0012 0.0053
Echinococcus granulosus expressed protein 0.0019 0.001 0.0047
Leishmania major hypothetical protein, conserved 0.0019 0.001 0.002
Onchocerca volvulus 0.0051 0.0074 0.0064
Brugia malayi Telomerase reverse transcriptase 0.3606 0.7261 1
Trypanosoma brucei unspecified product 0.002 0.0012 0.0025
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0028 0.0129
Giardia lamblia Telomerase catalytic subunit 0.1355 0.271 1
Echinococcus granulosus epidermal growth factor receptor kinase 0.0019 0.001 0.0047
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.005 0.0165
Schistosoma mansoni tyrosine kinase 0.0045 0.0062 0.0266
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0019 0.001 0.0026
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.002 0.0011 0.0052
Onchocerca volvulus 0.0081 0.0135 0.0125
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0013 0.0031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0022
Brugia malayi RhoGAP domain containing protein 0.002 0.0011 0.0009
Brugia malayi SH2 domain containing protein 0.0026 0.0023 0.0025
Schistosoma mansoni tyrosine kinase 0.0045 0.0062 0.0266
Loa Loa (eye worm) jmjC domain-containing protein 0.0083 0.0139 0.0658
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0028 0.0087
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0085 0.0142 0.0649
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.006 0.0205
Loa Loa (eye worm) hypothetical protein 0.0083 0.0139 0.0658
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.002 0.0011 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1206 0.241 1
Echinococcus multilocularis endophilin A3 0.0019 0.001 0.0047
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0019 0.001 0.0047
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0005 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0165 0.0747
Echinococcus granulosus SH2 motif 0.002 0.0011 0.0052
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1059 0.2112 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0025
Schistosoma mansoni importin beta-1 0.0028 0.0028 0.011
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.0062 0.0283
Leishmania major DNA polymerase kappa, putative 0.002 0.0012 0.0025
Schistosoma mansoni tyrosine kinase 0.0026 0.0023 0.0083
Onchocerca volvulus 0.0026 0.0023 0.0012
Loa Loa (eye worm) STAT protein 0.002 0.0011 0.0054
Echinococcus multilocularis Glycosyl transferase, family 8 0.0078 0.0129 0.0589
Schistosoma mansoni ran 0.0021 0.0013 0.0039
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0069 0.011 0.0387
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.005 0.033
Loa Loa (eye worm) hypothetical protein 0.0081 0.0135 0.0638
Brugia malayi jmjC domain containing protein 0.0083 0.0139 0.0185
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0038 0.0117
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0083 0.0139 0.0496
Schistosoma mansoni GTPase activating protein 0.002 0.0011 0.003
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0085 0.0142 0.0649
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0165 0.0221
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0062 0.0283
Onchocerca volvulus 0.002 0.0011 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Brugia malayi hypothetical protein 0.002 0.0011 0.0009
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0038 0.0124
Plasmodium vivax importin-beta 2, putative 0.0028 0.0028 0.0087
Onchocerca volvulus 0.1205 0.2408 0.24
Schistosoma mansoni vav2 0.0031 0.0033 0.0133
Echinococcus granulosus Glycosyltransferase protein LARGE1 0.0058 0.0088 0.0403
Brugia malayi SH2 domain containing protein 0.002 0.0011 0.0009
Echinococcus granulosus PHD finger protein rhinoceros 0.021 0.0395 0.1803
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1206 0.241 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0062 0.0283
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0177 0.0696
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.005 0.5
Echinococcus granulosus dnaJ subfamily B 0.0402 0.0784 0.3577
Schistosoma mansoni DNA polymerase eta 0.002 0.0012 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0049
Loa Loa (eye worm) hypothetical protein 0.0114 0.0202 0.0957
Entamoeba histolytica hypothetical protein 0.0023 0.0018 0.003
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0025 0.0027
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.002 0.0011 0.003
Schistosoma mansoni sorting nexin 0.0019 0.001 0.0026
Onchocerca volvulus 0.0028 0.0028 0.0018
Echinococcus multilocularis lamin dm0 0.0027 0.0025 0.0112
Echinococcus granulosus tensin C1 domain containing phosphatase 0.002 0.0011 0.0052
Echinococcus granulosus survival motor neuron protein 1 0.025 0.0476 0.2173
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0023 0.0103
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0083 0.0139 0.0496
Brugia malayi protein-tyrosine kinase 0.0026 0.0023 0.0025
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0012 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0054
Echinococcus multilocularis nostrin 0.0019 0.001 0.0047
Schistosoma mansoni sorbin 0.0019 0.001 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.1319 0.6018
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0013 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0049
Echinococcus multilocularis jumonji domain containing 1A 0.0083 0.0139 0.0635
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.003 0.0032 0.0147
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0028 0.0087
Loa Loa (eye worm) SH2 domain-containing protein 0.002 0.0011 0.0054
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0012 0.0005
Loa Loa (eye worm) protein-tyrosine kinase 0.0019 0.001 0.0049
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0013 0.0031
Onchocerca volvulus 0.0027 0.0025 0.0014
Schistosoma mansoni patched 1 0.0044 0.006 0.0255
Brugia malayi Sex muscle abnormal protein 5 0.0039 0.0051 0.0063
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0049
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0361 0.0702 0.096
Schistosoma mansoni nck2/grb4 0.0039 0.0051 0.0213
Echinococcus granulosus tyrosine protein kinase shark 0.0026 0.0023 0.0103
Echinococcus multilocularis SH2 domain containing adapter protein F 0.002 0.0011 0.0052
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0114 0.0202 0.0923
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.001 0.002
Echinococcus granulosus tensin 0.002 0.0011 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0022 0.0078
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0103 0.0459
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.0062 0.0283
Brugia malayi SH2 domain containing protein 0.002 0.0011 0.0009
Loa Loa (eye worm) TK/ABL protein kinase 0.0026 0.0023 0.0107
Loa Loa (eye worm) hypothetical protein 0.0044 0.006 0.0282
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.005 0.0165
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.004 0.019
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0028 0.0087
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0019 0.001 0.0047
Brugia malayi SRC-1 0.0045 0.0062 0.0079
Brugia malayi intermediate filament protein 0.0027 0.0025 0.0027
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.002 0.0011 0.0052
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0039 0.0051 0.024
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0019 0.001 0.0047
Brugia malayi Protein kinase domain containing protein 0.0026 0.0023 0.0025
Schistosoma mansoni cell polarity protein 0.0019 0.001 0.0026
Loa Loa (eye worm) TK/FER protein kinase 0.0026 0.0023 0.0107
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0019 0.001 0.0047
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.004 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Echinococcus multilocularis signal transduction protein lnk realted 0.002 0.0011 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Leishmania major GTP-binding protein, putative 0.0021 0.0013 0.0031
Echinococcus multilocularis tyrosine protein kinase Src42A 0.002 0.0011 0.0052
Brugia malayi tRNA modification GTPase TrmE family protein 0.002 0.0011 0.0009
Echinococcus granulosus expressed protein 0.0034 0.004 0.0183
Plasmodium falciparum importin beta, putative 0.0028 0.0028 0.0087
Brugia malayi Fes/CIP4 homology domain containing protein 0.0019 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0055
Echinococcus multilocularis suppressor of cytokine signaling 7 0.002 0.0011 0.0052
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0152 0.0279 0.1278
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0054
Echinococcus granulosus src region 0.0019 0.001 0.0047
Brugia malayi jmjC domain containing protein 0.0083 0.0139 0.0185
Loa Loa (eye worm) hypothetical protein 0.0075 0.0123 0.0585
Brugia malayi PHD-finger family protein 0.007 0.0113 0.0149
Brugia malayi protein-tyrosine kinase 0.0019 0.001 0.0008
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0019 0.001 0.0047
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0005 0.0023
Schistosoma mansoni Dab2-interacting protein-like 0.0019 0.001 0.0026
Echinococcus multilocularis expressed protein 0.0034 0.004 0.0183
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1206 0.241 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.002 0.0011 0.0054
Onchocerca volvulus 0.0081 0.0135 0.0125
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0062 0.0283
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0012 0.0031
Onchocerca volvulus 0.0027 0.0025 0.0014
Schistosoma mansoni cpg binding protein 0.003 0.0031 0.0124
Schistosoma mansoni formin binding protein and related proteins 0.0019 0.001 0.0026
Schistosoma mansoni hypothetical protein 0.0042 0.0056 0.024
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.002 0.0011 0.003
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0025
Echinococcus granulosus c src tyrosine kinase 0.0045 0.0062 0.0283
Schistosoma mansoni hypothetical protein 0.0019 0.001 0.0026
Schistosoma mansoni phosphatidylserine receptor 0.0083 0.0139 0.0625
Loa Loa (eye worm) hypothetical protein 0.007 0.0113 0.0534
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.005 0.0226
Entamoeba histolytica SH2 domain containing protein 0.002 0.0011 0.0004
Brugia malayi Peripheral plasma membrane protein CASK 0.0019 0.001 0.0008
Schistosoma mansoni apoptosis stimulating of P53 0.0019 0.001 0.0026
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0054
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0117
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0022
Schistosoma mansoni tyrosine kinase 0.1079 0.2152 1
Plasmodium vivax SET domain protein, putative 0.0152 0.0279 0.1014
Loa Loa (eye worm) hypothetical protein 0.0375 0.0729 0.3452
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0012 0.0005
Brugia malayi hypothetical protein 0.0037 0.0046 0.0057
Onchocerca volvulus 0.0026 0.0023 0.0012
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0204 0.0967
Brugia malayi Src substrate cortactin 0.0019 0.001 0.0008
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0012 0.0058
Plasmodium vivax telomerase reverse transcriptase, putative 0.1355 0.271 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0013 0.0012
Brugia malayi jmjC domain containing protein 0.0083 0.0139 0.0185
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0181 0.0819
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0022
Echinococcus multilocularis growth factor receptor bound protein 2 0.0039 0.0051 0.0231
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0152 0.0279 0.1274
Echinococcus multilocularis cpg binding protein 0.003 0.0031 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Schistosoma mansoni tensin-related 0.002 0.0011 0.003
Echinococcus multilocularis SHC transforming protein 3 0.002 0.0011 0.0052
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0361 0.0702 0.3322
Echinococcus granulosus Glycosyl transferase family 8 0.0078 0.0129 0.0589
Echinococcus multilocularis SH2 domain containing protein 7 0.002 0.0011 0.0052
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0019 0.001 0.0047
Echinococcus granulosus endophilin A3 0.0019 0.001 0.0047
Schistosoma mansoni lamin 0.0027 0.0025 0.0092
Leishmania major hypothetical protein, conserved 0.0083 0.0139 0.0496
Echinococcus multilocularis suppressor of cytokine signaling 7 0.002 0.0011 0.0052
Schistosoma mansoni hypothetical protein 0.0114 0.0202 0.0919
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0039 0.0051 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0012 0.0025
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0012 0.0053

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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