Detailed information for compound 593279

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 370.652 | Formula: C13H9BrClN3OS
  • H donors: 1 H acceptors: 2 LogP: 4.65 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccccc1CNc1noc(n1)c1sccc1Br
  • InChi: 1S/C13H9BrClN3OS/c14-9-5-6-20-11(9)12-17-13(18-19-12)16-7-8-3-1-2-4-10(8)15/h1-6H,7H2,(H,16,18)
  • InChiKey: PRXVKNGAZHJAPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Dopamine receptor protein 1 0.0444 0.5248 0.5843
Echinococcus granulosus chromobox protein 1 0.0075 0.071 0.1314
Brugia malayi AKH receptor 0.0035 0.0222 0.0234
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0425 0.0461
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0739 1
Loa Loa (eye worm) norepinephrine transporter 0.0456 0.5403 0.6018
Brugia malayi hypothetical protein 0.0035 0.0222 0.0234
Brugia malayi GnHR receptor homolog 0.0035 0.0222 0.0234
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0025 0.0096 0.0094
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.002 0.0029 0.0121
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0222 0.0411
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1785 0.5367
Trichomonas vaginalis glucosylceramidase, putative 0.0154 0.1683 0.5057
Toxoplasma gondii hypothetical protein 0.0077 0.0739 0.5408
Brugia malayi hypothetical protein 0.0035 0.0222 0.0234
Brugia malayi hypothetical protein 0.0035 0.0222 0.0234
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0222 0.0222
Toxoplasma gondii diaminopimelate decarboxylase 0.0043 0.032 0.2287
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0329 0.0329
Echinococcus granulosus lysine specific demethylase 6a 0.002 0.0029 0.0053
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Schistosoma mansoni zinc finger protein 0.002 0.0032 0.0059
Trichomonas vaginalis pyridoxal-dependent decarboxylase, putative 0.0043 0.032 0.0931
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3315 1
Schistosoma mansoni hypothetical protein 0.0035 0.0222 0.0411
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0023
Leishmania major C-8 sterol isomerase-like protein 0.0746 0.8974 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0027 0.0016
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0035 0.0222 0.0411
Onchocerca volvulus 0.0077 0.0739 0.105
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0069 0.0631 0.8512
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.3315 0.6126
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0027 0.0016
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0035 0.0222 0.0411
Brugia malayi Serotonin receptor 0.0035 0.0222 0.0234
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0027 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0222 0.0411
Brugia malayi hypothetical protein 0.0255 0.2924 0.3249
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0032 0.0022
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0035 0.0222 0.0411
Schistosoma mansoni biogenic amine receptor 0.0035 0.0222 0.0411
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.151 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0029 0.0018
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.025 0.0266
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Schistosoma mansoni amine GPCR 0.0199 0.2232 0.4131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0329 0.0609
Onchocerca volvulus 0.0052 0.0425 0.0449
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0025 0.0096 0.0096
Echinococcus granulosus zinc finger protein 0.002 0.0032 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0304 0.0882
Onchocerca volvulus 0.0035 0.0222 0.0058
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0722 0.1336
Schistosoma mansoni survival motor neuron protein 0.0052 0.0425 0.0787
Echinococcus multilocularis somatostatin receptor 0.0035 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.025 0.0266
Echinococcus granulosus bile acid beta glucosidase 0.0407 0.4799 0.8881
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.151 1
Trichomonas vaginalis chromobox protein, putative 0.0075 0.071 0.2112
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.017 0.0315
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0396 0.0733
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0235 0.2677 0.2974
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.025 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3315 1
Schistosoma mansoni hypothetical protein 0.033 0.3847 0.7119
Brugia malayi hypothetical protein 0.0035 0.0222 0.0234
Echinococcus multilocularis sodium and chloride dependent glycine 0.0077 0.0739 0.0739
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0035 0.0222 0.0411
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0329 0.0354
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0035 0.0222 0.0234
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0027 0.0016
Trichomonas vaginalis ornithine decarboxylase, putative 0.0043 0.032 0.0931
Brugia malayi hypothetical protein 0.0035 0.0222 0.0234
Brugia malayi jmjC domain containing protein 0.0201 0.2255 0.2503
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0025 0.0096 0.0178
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0181 0.1258
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0077 0.0739 0.0811
Mycobacterium ulcerans diaminopimelate decarboxylase LysA 0.0043 0.032 0.2053
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0025 0.0096 0.0094
Brugia malayi larval opioid receptor 0.0035 0.0222 0.0234
Schistosoma mansoni amine GPCR 0.0035 0.0222 0.0411
Onchocerca volvulus 0.0035 0.0222 0.0058
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0035 0.0222 0.0234
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.1356 0.2509
Onchocerca volvulus 0.0035 0.0222 0.0058
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0012 0.0012
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0222 0.0222
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0235 0.2677 0.2977
Toxoplasma gondii hypothetical protein 0.0077 0.0739 0.5408
Brugia malayi Bromodomain containing protein 0.0064 0.0569 0.0621
Leishmania major DNA polymerase eta, putative 0.002 0.0027 0.0016
Trichomonas vaginalis ornithine decarboxylase, putative 0.0043 0.032 0.0931
Trichomonas vaginalis diaminopimelate decarboxylase, putative 0.0043 0.032 0.0931
Echinococcus granulosus g protein coupled receptor 0.0035 0.0222 0.0411
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0077 0.0739 0.0739
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0222 0.0411
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0456 0.5403 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0222 0.0411
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0222 0.0411
Onchocerca volvulus Glucosylceramidase homolog 0.0154 0.1683 0.2861
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0222 0.0239
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0035 0.0222 0.0222
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.025 0.0721
Schistosoma mansoni amine GPCR 0.0035 0.0222 0.0411
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0222 0.0411
Echinococcus multilocularis neuropeptide FF receptor 2 0.0035 0.0222 0.0222
Onchocerca volvulus 0.0035 0.0222 0.0058
Echinococcus multilocularis g-protein coupled receptor 0.0035 0.0222 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.0235 0.2677 0.8068
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.025 0.1772
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Schistosoma mansoni bile acid beta-glucosidase-related 0.0407 0.4799 0.8881
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0029 0.0023
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.0539 0.0593
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0222 0.0411
Onchocerca volvulus 0.0077 0.0739 0.105
Trichomonas vaginalis set domain proteins, putative 0.0255 0.2929 0.8831
Onchocerca volvulus Huntingtin homolog 0.0125 0.1328 0.2181
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Loa Loa (eye worm) solute carrier family 6 member 4 0.0456 0.5403 0.6018
Onchocerca volvulus 0.0255 0.2929 0.5252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0329 0.0609
Loa Loa (eye worm) jmjC domain-containing protein 0.0127 0.1342 0.1489
Brugia malayi putative neuropeptide receptor NPR1 0.0035 0.0222 0.0234
Onchocerca volvulus 0.0035 0.0222 0.0058
Loa Loa (eye worm) hypothetical protein 0.0382 0.4481 0.499
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.1356 0.8974
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.0016
Trichomonas vaginalis diaminopimelate decarboxylase, putative 0.0043 0.032 0.0931
Schistosoma mansoni neuropeptide receptor 0.0035 0.0222 0.0411
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.1356 0.2509
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0222 0.0222
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.025 0.0721
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0333 0.0616
Schistosoma mansoni jumonji domain containing protein 0.0159 0.1748 0.3234
Schistosoma mansoni inositol monophosphatase 0.0038 0.025 0.0464
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0069 0.0631 0.8512
Schistosoma mansoni opsin-like receptor 0.0035 0.0222 0.0411
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0035 0.0222 0.0411
Schistosoma mansoni hypothetical protein 0.0021 0.0045 0.0083
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0343 0.029
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0202 0.1265
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Entamoeba histolytica ornithine decarboxylase, putative 0.0043 0.032 0.0931
Schistosoma mansoni neuropeptide f receptor 76f 0.0035 0.0222 0.0411
Echinococcus multilocularis G protein coupled receptor 139 0.0035 0.0222 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.0154 0.1683 0.5057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1356 0.8974
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Brugia malayi ORL1-like opioid receptor 0.0035 0.0222 0.0234
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0025 0.0096 0.0094
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0222 0.0222
Echinococcus granulosus hypothetical protein 0.0035 0.0222 0.0411
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0027 0.0044
Schistosoma mansoni protein phosphatase 2C 0.002 0.0029 0.0053
Brugia malayi neuropeptide F receptor 0.0035 0.0222 0.0234
Loa Loa (eye worm) hypothetical protein 0.0456 0.5403 0.6018
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0222 0.0411
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0035 0.0222 0.0239
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0077 0.0739 0.0811
Brugia malayi Tachykinin-like peptides receptor 99D 0.0035 0.0222 0.0234
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Echinococcus granulosus allatostatin A receptor 0.0035 0.0222 0.0411
Echinococcus multilocularis non lysosomal glucosylceramidase 0.0407 0.4799 0.4799
Echinococcus multilocularis lysine specific demethylase 6a 0.002 0.0029 0.0029
Brugia malayi jmjC domain containing protein 0.002 0.0029 0.0018
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0025 0.0096 0.0094
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0027 0.0016
Onchocerca volvulus 0.0077 0.0739 0.105
Schistosoma mansoni hypothetical protein 0.033 0.3847 0.7119
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0027 0.0096
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0027 0.0044
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0222 0.0411
Schistosoma mansoni neuropeptide receptor 0.0035 0.0222 0.0411
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0027 0.005
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Echinococcus granulosus G protein coupled receptor 139 0.0035 0.0222 0.0411
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0029 0.0018
Schistosoma mansoni ap endonuclease 0.0018 0.0012 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0222 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.0154 0.1683 0.5057
Loa Loa (eye worm) melatonin receptor type 1A 0.0035 0.0222 0.0239
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0181 0.0336
Echinococcus multilocularis chromobox protein 1 0.0075 0.071 0.071
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0027 0.005
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0025 0.0096 0.0099
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.025 0.0464
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.151 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1356 0.8974
Echinococcus multilocularis neuropeptide receptor A26 0.0035 0.0222 0.0222
Echinococcus granulosus peregrin 0.0064 0.0569 0.1053
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.3315 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0035 0.0222 0.0411
Plasmodium falciparum JmjC domain-containing protein, putative 0.002 0.0029 0.0224
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0035 0.0222 0.0411
Echinococcus multilocularis sex peptide receptor 0.0035 0.0222 0.0222
Brugia malayi Dopamine receptor protein 2 0.0035 0.0222 0.0234
Echinococcus multilocularis peregrin 0.0064 0.0569 0.0569
Brugia malayi Pre-SET motif family protein 0.0032 0.0181 0.0189
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0027 0.0096
Loa Loa (eye worm) hypothetical protein 0.0255 0.2924 0.3252
Mycobacterium tuberculosis Diaminopimelate decarboxylase LysA (DAP decarboxylase) 0.0043 0.032 0.2053
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.0016
Giardia lamblia Ornithine decarboxylase 0.0043 0.032 0.0931
Brugia malayi jmjC domain containing protein 0.002 0.0029 0.0018
Plasmodium falciparum phd finger protein, putative 0.0061 0.0539 0.7254
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0222 0.0411
Brugia malayi Dopamine receptor 0.0035 0.0222 0.0234
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0077 0.0739 0.0811
Brugia malayi hypothetical protein 0.0035 0.0222 0.0234
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Trypanosoma brucei C-8 sterol isomerase, putative 0.0746 0.8974 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0739 0.0816
Brugia malayi PHD-finger family protein 0.0022 0.0056 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3315 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0035 0.0222 0.0234
Brugia malayi Inositol-1 0.0038 0.025 0.0266
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0077 0.0739 0.1367
Echinococcus granulosus JmjC domain containing protein 4 0.002 0.0029 0.0053
Brugia malayi AF-10 protein 0.002 0.0032 0.0022
Brugia malayi G-protein coupled receptor 0.0035 0.0222 0.0234
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0222 0.0411
Schistosoma mansoni sodium-dependent amino acid transporter 0.0077 0.0739 0.1367
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.1356 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0027 0.0096
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0125 0.1328 0.1473
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0746 0.8974 1
Schistosoma mansoni DNA polymerase eta 0.002 0.0027 0.005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0032 0.0144
Echinococcus granulosus neuropeptide receptor 0.0035 0.0222 0.0411
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.0016
Onchocerca volvulus Alhambra homolog 0.0061 0.0539 0.0667
Trichomonas vaginalis glucosylceramidase, putative 0.0235 0.2677 0.8068
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0222 0.0411
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0035 0.0222 0.0222
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0077 0.0739 0.0816
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0722 0.1336
Schistosoma mansoni chromobox protein 0.0075 0.071 0.1314
Echinococcus granulosus PHD finger protein rhinoceros 0.0061 0.0539 0.0998
Echinococcus granulosus tachykinin peptides receptor 99D 0.0035 0.0222 0.0411
Schistosoma mansoni sodium/chloride dependent transporter 0.0077 0.0739 0.1367
Echinococcus granulosus serotonin transporter 0.0456 0.5403 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0035 0.0222 0.0411
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3315 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0035 0.0222 0.0411
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0222 0.0411
Echinococcus granulosus g protein coupled receptor 0.0035 0.0222 0.0411
Loa Loa (eye worm) hypothetical protein 0.0077 0.0739 0.0816
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0456 0.5403 0.6016
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.017 0.017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0329 0.0609
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0222 0.0411
Brugia malayi Bromodomain containing protein 0.0077 0.073 0.0801
Onchocerca volvulus Neuropeptide F receptor homolog 0.0035 0.0222 0.0058
Echinococcus multilocularis orexin receptor type 2 0.0035 0.0222 0.0222
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0746 0.8974 1
Onchocerca volvulus 0.0035 0.0222 0.0058
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0061 0.0539 0.0998
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0035 0.0222 0.0411
Schistosoma mansoni sodium/chloride dependent transporter 0.0077 0.0739 0.1367
Brugia malayi Melatonin receptor type 1A 0.0035 0.0222 0.0234
Schistosoma mansoni hypothetical protein 0.0035 0.0222 0.0411
Loa Loa (eye worm) hypothetical protein 0.0042 0.0298 0.0324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0222 0.0222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0222 0.0411
Brugia malayi G-protein coupled receptor 0.0035 0.0222 0.0234
Loa Loa (eye worm) hypothetical protein 0.0456 0.5403 0.6018
Loa Loa (eye worm) hypothetical protein 0.0068 0.0617 0.068
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3315 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0329 0.0329
Leishmania major hypothetical protein, conserved 0.002 0.0029 0.0018
Schistosoma mansoni hypothetical protein 0.0031 0.017 0.0315
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0222 0.0411
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0304 0.0215
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0222 0.0222
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0035 0.0222 0.0411
Schistosoma mansoni hypothetical protein 0.0031 0.017 0.0315
Echinococcus multilocularis dna polymerase kappa 0.002 0.0027 0.0027
Echinococcus granulosus orexin receptor type 2 0.0035 0.0222 0.0411
Echinococcus granulosus neuropeptide FF receptor 2 0.0035 0.0222 0.0411
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0077 0.0739 0.0816
Brugia malayi putative neuropeptide receptor 0.0035 0.0222 0.0234
Brugia malayi PHD-finger family protein 0.0025 0.0099 0.0097
Brugia malayi jmjC domain containing protein 0.002 0.0029 0.0018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0222 0.0411
Echinococcus multilocularis jumonji domain containing 1A 0.002 0.0029 0.0029
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0012 0.0005
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0069 0.0128
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0053 0.0097
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0222 0.0411
Loa Loa (eye worm) hypothetical protein 0.0039 0.0269 0.0291
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Loa Loa (eye worm) hypothetical protein 0.005 0.0396 0.0433
Schistosoma mansoni opsin-like receptor 0.0035 0.0222 0.0411
Schistosoma mansoni bromodomain containing protein 0.0065 0.0582 0.1078
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0222 0.0411
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0035 0.0222 0.0222
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0222 0.0411
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0025 0.0096 0.0094
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.3315 1
Echinococcus granulosus jumonji domain containing 1A 0.002 0.0029 0.0053
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0222 0.0411
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0222 0.0222
Brugia malayi sulfakinin receptor protein 0.0035 0.0222 0.0234
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0343 0.1001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0222 0.0222
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0396 0.0733
Loa Loa (eye worm) hypothetical protein 0.0061 0.0539 0.0593
Onchocerca volvulus 0.0035 0.0222 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Loa Loa (eye worm) hypothetical protein 0.0044 0.0322 0.0351
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0035 0.0222 0.0411
Echinococcus multilocularis serotonin receptor 0.0035 0.0222 0.0222
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0222 0.0411
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0222 0.0411
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0261 0.2993 0.3329
Schistosoma mansoni neuropeptide receptor 0.0035 0.0222 0.0411
Echinococcus granulosus 7TM GPCR rhodopsin 0.0035 0.0222 0.0411
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0029 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0222 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0304 0.0882
Echinococcus multilocularis JmjC domain containing protein 4 0.002 0.0029 0.0029
Schistosoma mansoni neuropeptide receptor 0.0035 0.0222 0.0411
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0222 0.0411
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0069 0.0069
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0035 0.0222 0.0239
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0222 0.0411
Echinococcus granulosus sodium and chloride dependent glycine 0.0077 0.0739 0.1367
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.0016
Trypanosoma brucei ornithine decarboxylase 0.0043 0.032 0.0343
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0027 0.0016
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0035 0.0222 0.0222
Onchocerca volvulus 0.0035 0.0222 0.0058
Plasmodium falciparum transporter, putative 0.0077 0.0739 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0035 0.0222 0.0234
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0077 0.0739 0.1367
Loa Loa (eye worm) hypothetical protein 0.0031 0.017 0.0181
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0069 0.0128
Schistosoma mansoni histamine h1 receptor 0.0035 0.0222 0.0411
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.2924 0.2924
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0035 0.0222 0.0234
Schistosoma mansoni phd/f-box containing protein 0.002 0.0029 0.0053
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0077 0.0739 0.1367
Brugia malayi G protein-coupled receptor 0.0035 0.0222 0.0234
Schistosoma mansoni ap endonuclease 0.0018 0.0012 0.0023
Echinococcus granulosus dro:myosuppressin receptor 0.0035 0.0222 0.0411
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0035 0.0222 0.0222
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0027 0.0016
Brugia malayi jmjC domain containing protein 0.002 0.0029 0.0018
Loa Loa (eye worm) hypothetical protein 0.0077 0.0739 0.0816
Loa Loa (eye worm) hypothetical protein 0.0125 0.1328 0.1473
Brugia malayi hypothetical protein 0.0035 0.0222 0.0234
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.1356 0.2509
Schistosoma mansoni amine GPCR 0.0035 0.0222 0.0411
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0027 0.0016
Trichomonas vaginalis chromobox protein, putative 0.0075 0.071 0.2112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3315 1
Brugia malayi Serotonin receptor 0.0035 0.0222 0.0234
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0077 0.0739 0.1367
Onchocerca volvulus 0.0035 0.0222 0.0058
Loa Loa (eye worm) hypothetical protein 0.0072 0.0676 0.0745
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Treponema pallidum sodium- and chloride- dependent transporter 0.0456 0.5403 1
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.025 0.025
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0617 0.0675
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.1356 0.1499
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0184 0.2045 0.3556
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0077 0.0739 0.1367
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.017 0.0315
Schistosoma mansoni phosphatidylserine receptor 0.002 0.0029 0.0053
Schistosoma mansoni opsin-like receptor 0.0035 0.0222 0.0411
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.017 0.0181
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0222 0.0239
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Schistosoma mansoni inositol monophosphatase 0.0038 0.025 0.0464
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0027 0.0016
Echinococcus multilocularis dna polymerase eta 0.002 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0105 0.1078 0.1194
Trichomonas vaginalis glucosylceramidase, putative 0.0154 0.1683 0.5057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0222 0.0411
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.0016
Onchocerca volvulus 0.0035 0.0222 0.0058
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0077 0.0739 0.5408
Echinococcus granulosus jumonji domain containing protein 0.0085 0.0835 0.1545
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0035 0.0222 0.0239
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0201 0.2255 0.4174
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0025 0.0096 0.0094
Echinococcus granulosus g protein coupled receptor 0.0035 0.0222 0.0411
Echinococcus multilocularis serotonin transporter 0.0456 0.5403 0.5403
Loa Loa (eye worm) inositol-1 0.0038 0.025 0.0271
Schistosoma mansoni alpha-1 adrenergic receptor 0.0035 0.0222 0.0411
Trichomonas vaginalis glucosylceramidase, putative 0.0154 0.1683 0.5057
Brugia malayi chromobox protein homolog 3 0.0042 0.0304 0.0325
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0222 0.0222
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0032 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0222 0.0222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0222 0.0411
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1785 0.5367
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0035 0.0222 0.0222
Brugia malayi Bromodomain containing protein 0.0039 0.0268 0.0285
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0222 0.0411
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0167 0.0309
Onchocerca volvulus Huntingtin homolog 0.0125 0.1328 0.2181
Onchocerca volvulus 0.0044 0.0333 0.0271
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0329 0.0358
Loa Loa (eye worm) hypothetical protein 0.0746 0.8974 1
Echinococcus multilocularis serotonin receptor 0.0035 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0077 0.0739 0.0816
Loa Loa (eye worm) hypothetical protein 0.0042 0.0304 0.033
Echinococcus granulosus neuropeptide s receptor 0.0035 0.0222 0.0411
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0077 0.0739 0.0739
Plasmodium vivax amine transporter, putative 0.0077 0.0739 1
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0222 0.0222
Plasmodium vivax JmjC domain containing protein 0.002 0.0029 0.0224
Loa Loa (eye worm) serotonin transporter b 0.0456 0.5403 0.6018
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0222 0.0222
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.002 0.0029 0.0018
Schistosoma mansoni hypothetical protein 0.0035 0.0222 0.0411
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0396 0.0733
Echinococcus multilocularis GPCR, family 2 0.0031 0.017 0.017
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0181 0.0181
Echinococcus multilocularis jumonji domain containing protein 0.0085 0.0835 0.0835
Schistosoma mansoni bile acid beta-glucosidase-related 0.0407 0.4799 0.8881
Echinococcus granulosus chromobox protein 1 0.0075 0.071 0.1314
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0027 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.0016
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0201 0.2255 0.2255
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.025 0.0721
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.3315 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0539 0.3923
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0222 0.0239
Echinococcus granulosus phd:f box containing protein 0.002 0.0029 0.0053
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0222 0.0222
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0035 0.0222 0.0222
Plasmodium vivax hypothetical protein, conserved 0.002 0.0032 0.0267
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Loa Loa (eye worm) hypothetical protein 0.0077 0.0739 0.0816
Echinococcus granulosus GPCR family 2 0.0031 0.017 0.0315
Onchocerca volvulus 0.0035 0.0222 0.0058
Brugia malayi Heterochromatin protein 1 0.0075 0.071 0.0778
Echinococcus multilocularis G-protein coupled receptor, putative 0.0035 0.0222 0.0222
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1356 0.8974
Brugia malayi PHD-finger family protein 0.0061 0.0539 0.0588
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.0275 0.3169 0.3526
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1002 0.1104
Loa Loa (eye worm) hypothetical protein 0.0022 0.0056 0.0054
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0222 0.0411
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0222 0.0411
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.071 0.0783
Schistosoma mansoni hypothetical protein 0.0031 0.017 0.0315
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0222 0.0411
Schistosoma mansoni hypothetical protein 0.002 0.0032 0.0059
Brugia malayi jmjC domain containing protein 0.0076 0.0722 0.0792
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0537 0.0994
Loa Loa (eye worm) hypothetical protein 0.0456 0.5403 0.6018
Echinococcus multilocularis neuropeptide s receptor 0.0035 0.0222 0.0222
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1002 0.1104
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Onchocerca volvulus 0.0035 0.0222 0.0058
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.025 0.0266
Echinococcus granulosus 7tm_1 domain containing protein 0.0035 0.0222 0.0411
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0027 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.0235 0.2677 0.8068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0329 0.0609
Trichomonas vaginalis glucosylceramidase, putative 0.0154 0.1683 0.5057
Onchocerca volvulus 0.0035 0.0222 0.0058
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0077 0.0739 0.1367
Schistosoma mansoni hypothetical protein 0.0061 0.0539 0.0998
Loa Loa (eye worm) hypothetical protein 0.0077 0.0739 0.0816
Echinococcus granulosus non lysosomal glucosylceramidase 0.0407 0.4799 0.8881
Schistosoma mansoni sodium/chloride dependent transporter 0.0456 0.5403 1
Echinococcus multilocularis geminin 0.033 0.3847 0.3847
Schistosoma mansoni adenoreceptor 0.0035 0.0222 0.0411
Loa Loa (eye worm) hypothetical protein 0.0184 0.2045 0.2272
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Giardia lamblia DINP protein human, muc B family 0.002 0.0027 0.0044
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.025 0.1591
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0152 0.0423
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0035 0.0222 0.0222
Echinococcus granulosus somatostatin receptor 0.0035 0.0222 0.0411
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0029 0.0023
Onchocerca volvulus 0.0035 0.0222 0.0058
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0027 0.0096
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0329 0.0609
Brugia malayi hypothetical protein 0.0125 0.1328 0.1469
Loa Loa (eye worm) hypothetical protein 0.0444 0.5248 0.5845
Toxoplasma gondii histone lysine demethylase JMJD6a 0.002 0.0029 0.0121
Brugia malayi hypothetical protein 0.0035 0.0222 0.0234
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0343 0.1001
Loa Loa (eye worm) TYRA-2 protein 0.0035 0.0222 0.0239
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0077 0.0739 0.1367
Schistosoma mansoni amine GPCR 0.0035 0.0222 0.0411
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.002 0.0029 0.0053
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Plasmodium falciparum amino acid transporter, putative 0.0077 0.0739 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0077 0.0739 0.1367
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.025 0.0721
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0077 0.0739 0.1367
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0027 0.005
Brugia malayi follicle stimulating hormone receptor 0.0261 0.2993 0.3326
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0045 0.0042
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0222 0.0411
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0222 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0152 0.0423
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0077 0.0739 0.0739
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3315 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0224 0.2547 0.2833
Brugia malayi RE15519p 0.0035 0.0222 0.0234
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0077 0.0739 0.5408
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0222 0.0222
Plasmodium vivax SET domain protein, putative 0.0032 0.0181 0.2327
Echinococcus granulosus neuropeptide receptor A26 0.0035 0.0222 0.0411
Echinococcus granulosus g-protein coupled receptor 0.0035 0.0222 0.0411
Echinococcus granulosus dna polymerase eta 0.002 0.0027 0.005
Leishmania major DNA polymerase kappa, putative 0.002 0.0027 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0023
Echinococcus multilocularis sodium and chloride dependent glycine 0.0077 0.0739 0.0739
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0077 0.0739 0.1367
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.0016
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0222 0.0222
Echinococcus multilocularis PHD finger protein rhinoceros 0.0061 0.0539 0.0539
Echinococcus multilocularis dro:myosuppressin receptor 0.0035 0.0222 0.0222
Brugia malayi N-terminal motif family protein 0.0184 0.2045 0.2268
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.025 0.0266
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.2924 0.5411
Trichomonas vaginalis glucosylceramidase, putative 0.0154 0.1683 0.5057
Leishmania major ornithine decarboxylase, putative 0.0043 0.032 0.0343
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0222 0.0411
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.1356 0.1356
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1002 0.1109
Loa Loa (eye worm) hypothetical protein 0.0099 0.1002 0.1109
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.017 0.0176
Brugia malayi Latrophilin receptor protein 2 0.0031 0.017 0.0176
Echinococcus granulosus sodium and chloride dependent glycine 0.0077 0.0739 0.1367
Leishmania major S-adenosylmethionine decarboxylase 0.0025 0.0096 0.0094
Trichomonas vaginalis glucosylceramidase, putative 0.0235 0.2677 0.8068
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.002 0.0032 0.0267
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0077 0.0739 0.0816
Brugia malayi hypothetical protein 0.0035 0.0222 0.0234
Schistosoma mansoni myosin xvIII 0.0035 0.0222 0.0411
Brugia malayi neuropeptide F receptor 0.0035 0.0222 0.0234
Echinococcus granulosus sex peptide receptor 0.0035 0.0222 0.0411
Onchocerca volvulus 0.0035 0.0222 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.3315 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0077 0.0739 0.5408
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Loa Loa (eye worm) hypothetical protein 0.0033 0.0192 0.0205
Schistosoma mansoni jumonji domain containing protein 0.002 0.0029 0.0053
Giardia lamblia PHD finger protein 15 0.0061 0.0539 0.1596
Schistosoma mansoni biogenic amine receptor 0.0035 0.0222 0.0411
Onchocerca volvulus 0.0035 0.0222 0.0058
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Echinococcus granulosus lysine specific demethylase 5A 0.0076 0.0722 0.1336
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0222 0.0411
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0046 0.0086
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0077 0.0739 0.0811
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0077 0.0739 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0722 0.0797
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.017 0.017
Brugia malayi Pre-SET motif family protein 0.0224 0.2547 0.2829
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0027 0.0016
Schistosoma mansoni hypothetical protein 0.0068 0.0617 0.1142
Onchocerca volvulus 0.0456 0.5403 1
Echinococcus granulosus geminin 0.033 0.3847 0.7119
Echinococcus multilocularis chromobox protein 1 0.0075 0.071 0.071
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0238 0.044
Trypanosoma brucei unspecified product 0.002 0.0027 0.0016
Echinococcus granulosus dna polymerase kappa 0.002 0.0027 0.005
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0222 0.0411
Echinococcus granulosus fmrfamide receptor 0.0035 0.0222 0.0411
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0027 0.0016
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0012 0.0023
Echinococcus multilocularis zinc finger protein 0.002 0.0032 0.0032
Schistosoma mansoni biogenic amine receptor 0.0035 0.0222 0.0411
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0077 0.0739 0.1367
Brugia malayi Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein 0.0043 0.032 0.0343
Echinococcus multilocularis lysine specific demethylase 5A 0.0074 0.0698 0.0698
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0222 0.0222
Loa Loa (eye worm) pyridoxal-dependent decarboxylase 0.0043 0.032 0.0348
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0239
Onchocerca volvulus 0.0035 0.0222 0.0058
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0035 0.0222 0.0234
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0222 0.0222
Schistosoma mansoni hypothetical protein 0.0031 0.017 0.0315
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0222 0.0411
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0027 0.0016
Echinococcus granulosus serotonin receptor 0.0035 0.0222 0.0411
Echinococcus multilocularis bile acid beta glucosidase 0.0407 0.4799 0.4799
Echinococcus multilocularis allatostatin A receptor 0.0035 0.0222 0.0222
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0035 0.0222 0.0058
Echinococcus multilocularis phd:f box containing protein 0.002 0.0029 0.0029
Echinococcus granulosus alpha 1A adrenergic receptor 0.0035 0.0222 0.0411
Echinococcus granulosus neuropeptide receptor 0.0035 0.0222 0.0411
Schistosoma mansoni hypothetical protein 0.0052 0.0425 0.0787
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0222 0.0222
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0032 0.0144
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0222 0.0411
Brugia malayi hypothetical protein 0.0035 0.0222 0.0234
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0539 0.3923
Schistosoma mansoni chromobox protein 0.0075 0.071 0.1314
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0537 0.0537
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0539 0.7254
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0222 0.0222
Echinococcus granulosus peptide allatostatin:somatostatin 0.0035 0.0222 0.0411
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0035 0.0222 0.0239
Trichomonas vaginalis glucosylceramidase, putative 0.0235 0.2677 0.8068
Schistosoma mansoni hypothetical protein 0.0035 0.0222 0.0411
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0077 0.0739 0.1367
Trichomonas vaginalis glucosylceramidase, putative 0.0235 0.2677 0.8068
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0027 0.0021
Onchocerca volvulus 0.0043 0.032 0.0246
Brugia malayi hypothetical protein 0.0077 0.0739 0.0811

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 0.33 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 1.17 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 2.84 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 93 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 97 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 9.09 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -7 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 0 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 93 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 97 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.1 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.78747 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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