Detailed information for compound 61166

Basic information

Technical information
  • TDR Targets ID: 61166
  • Name: 2-(2-fluorophenyl)-2-(4-fluorophenyl)-2-pheny lacetamide
  • MW: 323.336 | Formula: C20H15F2NO
  • H donors: 1 H acceptors: 1 LogP: 4.11 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C(c1ccccc1F)(c1ccccc1)C(=O)N
  • InChi: 1S/C20H15F2NO/c21-16-12-10-15(11-13-16)20(19(23)24,14-6-2-1-3-7-14)17-8-4-5-9-18(17)22/h1-13H,(H2,23,24)
  • InChiKey: UFALWTGZIJAUPP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-fluorophenyl)-2-(4-fluorophenyl)-2-phenyl-acetamide
  • 2-(2-fluorophenyl)-2-(4-fluorophenyl)-2-phenyl-ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, KQT-like subfamily, member 1 References
Homo sapiens potassium voltage-gated channel, Isk-related family, member 1 Starlite/ChEMBL References
Homo sapiens potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans ion transport protein Get druggable targets OG5_135025 All targets in OG5_135025
Leishmania infantum ion transport protein-like protein Get druggable targets OG5_138713 All targets in OG5_138713
Leishmania major ion transport protein-like protein Get druggable targets OG5_138713 All targets in OG5_138713
Leishmania donovani ion transport protein-like protein Get druggable targets OG5_138713 All targets in OG5_138713
Trypanosoma cruzi ion transport protein, putative Get druggable targets OG5_138713 All targets in OG5_138713
Trypanosoma cruzi ion transport protein, putative Get druggable targets OG5_138713 All targets in OG5_138713
Leishmania mexicana ion transport protein-like protein Get druggable targets OG5_138713 All targets in OG5_138713
Leishmania braziliensis ion transport protein-like protein Get druggable targets OG5_138713 All targets in OG5_138713
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi hypothetical protein potassium voltage-gated channel, Isk-related family, member 1 129 aa 107 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.001 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0443 0.1909
Schistosoma mansoni histidyl-tRNA synthetase 0.0011 0.0005 0.0001
Echinococcus granulosus calcium dependent protein kinase 0.009 0.0607 0.1209
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Mycobacterium ulcerans lipase LipD 0.0035 0.0193 0.2428
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0199
Brugia malayi Sugar transporter family protein 0.0044 0.0259 0.0758
Mycobacterium ulcerans hypothetical protein 0.0035 0.0193 0.2428
Schistosoma mansoni lipoxygenase 0.0116 0.0801 0.1587
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0078 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0215 0.0917
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.002 0.0078 0.0219
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.0661 0.8747
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0011 0.0005 0.0004
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0018 0.0059 0.0695
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0062 0.025
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0007 0.0005
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.002 0.0078 0.0219
Leishmania major ion transport protein-like protein 0.0134 0.0936 1
Plasmodium vivax proline--tRNA ligase, putative 0.011 0.0755 0.0751
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.0005
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0094 0.0637 0.1092
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0193 0.2015
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0015
Echinococcus multilocularis Chromo domain 0.0011 0.001 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0259 0.1107
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0199
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.001 0.0015
Mycobacterium ulcerans transmembrane cation transporter 0.002 0.0078 0.0951
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0106 0.0724 0.2636
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0011
Echinococcus multilocularis solute carrier family 22 0.0044 0.0259 0.0444
Brugia malayi steroid hormone receptor 0.0011 0.0007 0.0005
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0315 0.2299 0.3939
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0062 0.0741
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0315 0.2299 0.4577
Trypanosoma brucei glucose transporter, putative 0.0098 0.0661 0.8747
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.001
Onchocerca volvulus 0.002 0.0078 0.0558
Trypanosoma brucei glucose transporter, putative 0.0098 0.0661 0.8747
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0062 0.0057
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0039 0.0217 0.0634
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.0259 0.0758
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0259 0.1107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0096 0.0652 0.1298
Schistosoma mansoni hypothetical protein 0.0403 0.2964 0.5898
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0193 0.094
Brugia malayi hypothetical protein 0.0011 0.001 0.0015
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.011 0.0755 0.8058
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.002 0.0078 0.0219
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0237 0.1013
Onchocerca volvulus Glucosylceramidase homolog 0.0181 0.1293 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Echinococcus multilocularis chromobox protein 2 0.0011 0.001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0193 0.056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0193 0.056
Onchocerca volvulus 0.0044 0.0259 0.1961
Echinococcus granulosus dnaJ subfamily B 0.0403 0.2964 0.5902
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1293 0.5614
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0057 0.0086
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.002 0.0078 0.0219
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0078 0.0146
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0096 0.0652 0.1298
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0193 0.2517
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0018 0.0059 0.0098
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.0661 0.8747
Echinococcus granulosus twik family of potassium channels 0.002 0.0078 0.0156
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0285 0.0567
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0101 0.1246
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0276 0.201 0.5982
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1293 0.5614
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Trichomonas vaginalis conserved hypothetical protein 0.0315 0.2299 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0508 0.3761 0.3758
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0007 0.0005
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0011 0.0005 0.0004
Mycobacterium ulcerans lysyl-tRNA synthetase 0.007 0.0455 0.5823
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0035 0.0193 0.056
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.001 0.0021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0101 0.0979
Onchocerca volvulus 0.0044 0.0259 0.1961
Brugia malayi beta-lactamase 0.0035 0.0193 0.056
Brugia malayi follicle stimulating hormone receptor 0.0455 0.3356 1
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0078 0.0146
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0007 0.0011
Toxoplasma gondii transporter, major facilitator family protein 0.0044 0.0259 0.0383
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0013
Onchocerca volvulus 0.0044 0.0259 0.1961
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0058 0.0232
Chlamydia trachomatis proline--tRNA ligase 0.0033 0.0177 0.3815
Loa Loa (eye worm) hypothetical protein 0.0077 0.0504 0.1488
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.002 0.0078 0.0219
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0285 0.0488
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.005 0.004
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Onchocerca volvulus 0.002 0.0078 0.0558
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0101 0.0979
Schistosoma mansoni hypothetical protein 0.0315 0.2299 0.4572
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0044 0.0259 0.1356
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.001 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0702 0.208
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0003
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0096 0.0652 0.0977
Entamoeba histolytica protein kinase, putative 0.0096 0.0652 0.2373
Schistosoma mansoni hypothetical protein 0.0048 0.0285 0.0557
Schistosoma mansoni lysyl-tRNA synthetase 0.007 0.0455 0.0897
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0131 0.0548
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0193 0.2501
Loa Loa (eye worm) voltage-gated potassium channel 0.0123 0.0857 0.2542
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0285 0.0834
Plasmodium vivax potassium channel, putative 0.002 0.0078 0.0073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.005 0.004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0011
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.002 0.0078 0.0219
Toxoplasma gondii ion channel protein 0.002 0.0078 0.0111
Echinococcus granulosus potassium channel subfamily K 0.002 0.0078 0.0156
Entamoeba histolytica hypothetical protein 0.0011 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0005
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Trichomonas vaginalis esterase, putative 0.0035 0.0193 0.0818
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.201 0.8739
Giardia lamblia Hypothetical protein 0.002 0.0078 0.0269
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0215 0.1622
Plasmodium falciparum potassium channel 0.002 0.0078 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0193 0.0374
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0057 0.0052
Trypanosoma cruzi histidyl-tRNA synthetase 0.0011 0.0005 0.0004
Echinococcus multilocularis potassium channel subfamily K 8 0.002 0.0078 0.0134
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0193 0.2428
Onchocerca volvulus 0.002 0.0078 0.0558
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Onchocerca volvulus 0.0035 0.0193 0.1446
Mycobacterium tuberculosis Conserved protein 0.0035 0.0193 0.094
Trichomonas vaginalis sugar transporter, putative 0.0098 0.0661 0.2861
Leishmania major glucose transporter, lmgt3 0.0098 0.0661 0.7048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0193 0.056
Plasmodium falciparum calcium-dependent protein kinase 4 0.0096 0.0652 0.0648
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0011 0.0005 0.0002
Schistosoma mansoni hypothetical protein 0.0103 0.0702 0.1389
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0007 0.0013
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0096 0.0652 0.0648
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0661 0.2861
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.002 0.0078 0.0219
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0043 0.041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0193 0.2015
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0072 0.0123
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.011 0.0755 0.8058
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0215 0.0628
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0078 0.0146
Echinococcus multilocularis chromobox protein 1 0.0069 0.0443 0.0759
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0652 0.2821
Schistosoma mansoni protein kinase 0.0096 0.0652 0.1289
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0101 0.1246
Trypanosoma brucei histidyl-tRNA synthetase 0.0011 0.0005 0.0005
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0007 0.0005
Onchocerca volvulus 0.002 0.0078 0.0558
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.201 0.8739
Trichomonas vaginalis glucose transporter, putative 0.0044 0.0259 0.1107
Trypanosoma brucei glucose transporter, putative 0.0098 0.0661 0.8747
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.1649 0.3283
Echinococcus multilocularis Chromobox protein 3 0.0011 0.001 0.0017
Toxoplasma gondii lysine-tRNA ligase 0.007 0.0455 0.0679
Plasmodium vivax glycine--tRNA ligase, putative 0.0018 0.0059 0.0054
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0078 0.0146
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Echinococcus multilocularis RUN 0.0019 0.0072 0.0123
Onchocerca volvulus 0.0011 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Schistosoma mansoni chromobox protein 0.0069 0.0443 0.0873
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0287
Leishmania major hypothetical protein, conserved 0.0035 0.0193 0.2015
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Onchocerca volvulus Putative transporter 0.0044 0.0259 0.1961
Trichomonas vaginalis glucose transporter, putative 0.0098 0.0661 0.2861
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Leishmania major myo-inositol/proton symporter (MIT) 0.0044 0.0259 0.2727
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0011
Schistosoma mansoni ap endonuclease 0.0018 0.0062 0.0114
Trypanosoma brucei sugar transporter, putative 0.0044 0.0259 0.3384
Onchocerca volvulus 0.0044 0.0259 0.1961
Trypanosoma brucei calcium-activated potassium channel, putative 0.002 0.0078 0.0979
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.002 0.0078 0.0219
Loa Loa (eye worm) hypothetical protein 0.0048 0.0285 0.0834
Echinococcus granulosus solute carrier family 22 0.0044 0.0259 0.0515
Trypanosoma brucei glucose transporter, putative 0.0098 0.0661 0.8747
Entamoeba histolytica hypothetical protein 0.007 0.0455 0.1651
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.002 0.0078 0.0979
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0193 0.2428
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.002 0.0078 0.0219
Echinococcus multilocularis cpg binding protein 0.003 0.0151 0.0258
Brugia malayi hypothetical protein 0.002 0.0078 0.0219
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0057 0.115
Loa Loa (eye worm) major facilitator superfamily transporter 0.0044 0.0259 0.0758
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0013
Leishmania major lysyl-tRNA synthetase, putative 0.007 0.0455 0.4833
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1293 0.5614
Onchocerca volvulus 0.002 0.0078 0.0558
Brugia malayi major facilitator superfamily protein 0.0044 0.0259 0.0758
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0059 0.0576
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0315 0.2299 0.4577
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.001 0.0021
Onchocerca volvulus 0.0044 0.0259 0.1961
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0022 0.0034
Toxoplasma gondii sugar transporter ST3 0.0044 0.0259 0.0383
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0096 0.0652 0.1931
Onchocerca volvulus 0.0035 0.0193 0.1446
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0096 0.0652 0.1117
Brugia malayi nuclear receptor NHR-88 0.0011 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1366 0.5935
Schistosoma mansoni calcium-activated potassium channel 0.002 0.0078 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.201 0.8739
Leishmania major glucose transporter/membrane transporter D2, putative 0.0098 0.0661 0.7048
Mycobacterium leprae Probable lipase LipE 0.0035 0.0193 0.2517
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.002 0.0078 0.0219
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0033 0.0177 0.2222
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.0013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.1061 0.3152
Giardia lamblia Threonyl-tRNA synthetase 0.0018 0.0059 0.0197
Brugia malayi hypothetical protein 0.0019 0.0072 0.0199
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0062 0.025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0259 0.0505
Leishmania major hypothetical protein, conserved 0.0016 0.0043 0.041
Toxoplasma gondii ion channel protein 0.002 0.0078 0.0111
Brugia malayi Sugar transporter family protein 0.0044 0.0259 0.0758
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0058 0.0232
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.5837 1
Schistosoma mansoni twik family of potassium channels-related 0.0229 0.1654 0.3286
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0011 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Trichomonas vaginalis chromobox protein, putative 0.0011 0.001 0.0021
Brugia malayi Heterochromatin protein 1 0.0069 0.0443 0.1307
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Onchocerca volvulus 0.0044 0.0259 0.1961
Brugia malayi hypothetical protein 0.0019 0.0072 0.0199
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0096 0.0652 0.0977
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.002 0.0078 0.0219
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0094 0.0637 0.2756
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.1061 0.3152
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0237 0.1793
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0057 0.0052
Schistosoma mansoni rab6-interacting 0.0019 0.0072 0.0133
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.016
Brugia malayi chromobox protein homolog 3 0.0038 0.0215 0.0628
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0154
Loa Loa (eye worm) hypothetical protein 0.0151 0.1061 0.3152
Echinococcus granulosus chromobox protein 2 0.0011 0.001 0.002
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0101 0.0287
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Echinococcus multilocularis twik family of potassium channels 0.002 0.0078 0.0134
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0043 0.041
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0154
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0127 0.0886 0.1518
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.0259 0.0758
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0062 0.0124
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0101 0.0353
Echinococcus granulosus cpg binding protein 0.003 0.0151 0.03
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0062 0.012
Echinococcus granulosus TWiK family of potassium channels protein 7 0.002 0.0078 0.0156
Loa Loa (eye worm) TWK-28 protein 0.002 0.0078 0.0219
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0096 0.0652 0.0977
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0101 0.0353
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0011 0.0005 0.0001
Leishmania major calcium/potassium channel (CAKC), putative 0.002 0.0078 0.0789
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0096 0.0652 0.8623
Schistosoma mansoni histidyl-tRNA synthetase 0.0011 0.0005 0.0001
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0508 0.3761 0.5668
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.001 0.0021
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.011 0.0755 0.8058
Echinococcus granulosus geminin 0.0675 0.5023 1
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.0005
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.001 0.0005
Brugia malayi lysyl-tRNA synthetase 0.007 0.0455 0.1343
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.002 0.0078 0.0222
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.0259 0.0758
Schistosoma mansoni chromobox protein 0.0069 0.0443 0.0873
Leishmania major hypothetical protein, conserved 0.0044 0.0259 0.2727
Trypanosoma cruzi sugar transporter, putative 0.0044 0.0259 0.2727
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Brugia malayi beta-lactamase family protein 0.0035 0.0193 0.056
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0259 0.1107
Loa Loa (eye worm) TWK-7 protein 0.002 0.0078 0.0219
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0015
Trypanosoma cruzi hexose transporter, putative 0.0098 0.0661 0.7048
Echinococcus granulosus chromobox protein 1 0.0069 0.0443 0.0882
Brugia malayi beta-lactamase family protein 0.0035 0.0193 0.056
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0285 0.0834
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0101 0.1034
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0094 0.0637 0.1269
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1293 0.5614
Brugia malayi hypothetical protein 0.002 0.0078 0.0219
Echinococcus granulosus glycyl tRNA synthetase 0.0018 0.0059 0.0117
Onchocerca volvulus 0.003 0.0153 0.1135
Loa Loa (eye worm) hypothetical protein 0.0035 0.0193 0.056
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0096 0.0652 0.1298
Mycobacterium ulcerans hypothetical protein 0.0016 0.0043 0.0494
Plasmodium vivax hypothetical protein, conserved 0.0011 0.001 0.0005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0285 0.0488
Onchocerca volvulus 0.0044 0.0259 0.1961
Echinococcus multilocularis lysyl tRNA synthetase 0.007 0.0455 0.0779
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0044 0.0259 1
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0072 0.0199
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.0005
Entamoeba histolytica protein kinase, putative 0.0096 0.0652 0.2373
Plasmodium falciparum lysine--tRNA ligase 0.007 0.0455 0.045
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.0005
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0011 0.0005 0.0009
Echinococcus granulosus Threonyl tRNA synthetase C 0.0018 0.0059 0.0117
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0229 0.1654 0.3293
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0094 0.0637 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0193 0.056
Mycobacterium tuberculosis Conserved protein 0.0035 0.0193 0.094
Echinococcus multilocularis calcium activated potassium channel variant 0.002 0.0078 0.0134
Loa Loa (eye worm) helicase 0.0011 0.001 0.0015
Toxoplasma gondii ABC1 family protein 0.0035 0.0193 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.0005
Schistosoma mansoni sugar transporter 0.0044 0.0259 0.0506
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0057 0.067
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.006 0.0375 0.5587
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0058 0.0232
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0058 0.0232
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Plasmodium falciparum calcium-dependent protein kinase 5 0.0096 0.0652 0.0648
Loa Loa (eye worm) hypothetical protein 0.0071 0.0464 0.137
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0018 0.0059 0.016
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.001 0.001
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0094 0.0637 0.2319
Leishmania major hypothetical protein, conserved 0.002 0.0078 0.0789
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Leishmania major hypothetical protein, conserved 0.002 0.0078 0.0789
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0812 0.2409
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0058 0.0232
Entamoeba histolytica hypothetical protein 0.0011 0.001 0.0018
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.001 0.0021
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0007 0.0003
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0062 0.039 0.1677
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.011 0.0755 0.1132
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0043 0.0166
Plasmodium vivax hypothetical protein, conserved 0.0011 0.001 0.0005
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.002 0.0078 0.0219
Schistosoma mansoni survival motor neuron protein 0.0047 0.0277 0.0542
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0072 0.0067
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.2964 0.5079
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Loa Loa (eye worm) hypothetical protein 0.0094 0.0637 0.1887
Trichomonas vaginalis myo-inositol transporter, putative 0.0044 0.0259 0.1107
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0044 0.0259 0.3384
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0007 0.0003
Trichomonas vaginalis chromobox protein, putative 0.0011 0.001 0.0021
Schistosoma mansoni calcium-activated potassium channel 0.0136 0.0948 0.1879
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0036 0.0134
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0062 0.0171
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0096 0.0652 0.0648
Echinococcus multilocularis glycyl tRNA synthetase 0.0018 0.0059 0.0101
Onchocerca volvulus 0.0028 0.0139 0.1025
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0287
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.0005
Entamoeba histolytica hypothetical protein 0.0011 0.001 0.0018
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0007 0.0011
Onchocerca volvulus 0.0035 0.0193 0.1446
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0259 0.1107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0096 0.0652 0.1117
Trypanosoma cruzi glucose transporter, putative 0.0044 0.0259 0.2727
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.006 0.0375 0.2086
Trichomonas vaginalis chromobox protein, putative 0.0011 0.001 0.0021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0285 0.0834
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0101 0.1034
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0007 0.0003
Trypanosoma cruzi hexose transporter, putative 0.0098 0.0661 0.7048
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.001 0.0015
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0072 0.0143
Onchocerca volvulus 0.0044 0.0259 0.1961
Brugia malayi hypothetical protein 0.0044 0.0259 0.0758
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0062 0.3334
Onchocerca volvulus 0.0044 0.0259 0.1961
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0101 0.0287
Onchocerca volvulus 0.0044 0.0259 0.1961
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0015
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0259 0.0757
Schistosoma mansoni lysyl-tRNA synthetase 0.007 0.0455 0.0897
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0078 0.032
Schistosoma mansoni glucose transport protein 0.0315 0.2299 0.4572
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0094 0.0637 0.1887
Trypanosoma cruzi calcium-activated potassium channel, putative 0.002 0.0078 0.0789
Plasmodium vivax CDK-related protein kinase 6, putative 0.1335 1 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0193 0.056
Mycobacterium ulcerans beta-lactamase 0.0035 0.0193 0.2428
Schistosoma mansoni hypothetical protein 0.0048 0.0285 0.0557
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0455 0.3356 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Toxoplasma gondii facilitative glucose transporter GT1 0.0315 0.2299 0.3462
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0277 0.0811
Plasmodium falciparum calcium-dependent protein kinase 2 0.0096 0.0652 0.0648
Plasmodium vivax sugar transporter, putative 0.0044 0.0259 0.0254
Treponema pallidum prolyl-tRNA synthetase 0.0033 0.0177 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0259 0.0757
Schistosoma mansoni hypothetical protein 0.0156 0.1101 0.2185
Plasmodium vivax hexose transporter 0.0315 0.2299 0.2295
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0259 0.1107
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0078 0.0146
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0812 0.2409
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0022 0.0051
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.011 0.0755 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0237 0.1013
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0018 0.0059 0.016
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0018 0.0059 0.0101
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0078 0.032
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.011 0.0755 0.8058
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0062 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.0005
Echinococcus granulosus histidyl tRNA synthetase 0.0011 0.0005 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1293 0.5614
Chlamydia trachomatis histidine--tRNA ligase 0.0011 0.0005 0.0008
Brugia malayi Sugar transporter family protein 0.0315 0.2299 0.6845
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0131 0.0548
Trypanosoma brucei glucose transporter 1E 0.0098 0.0661 0.8747
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0078 0.0146
Schistosoma mansoni cpg binding protein 0.003 0.0151 0.029
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0044 0.0259 0.3286
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Schistosoma mansoni loxhd1 0.0019 0.0072 0.0133
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0018 0.0059 0.0715
Brugia malayi glycyl-tRNA synthetase 0.0018 0.0059 0.016
Schistosoma mansoni coup transcription factor 0.0011 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0044 0.0259 0.0254
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0018 0.0059 0.0715
Brugia malayi hypothetical protein 0.0044 0.0259 0.0758
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.001 0.0021
Schistosoma mansoni hypothetical protein 0.0675 0.5023 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0062 0.0763
Echinococcus multilocularis General substrate transporter 0.027 0.1965 0.3367
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0022 0.0044
Echinococcus multilocularis twik family of potassium channels 0.002 0.0078 0.0134
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Schistosoma mansoni polycystin 1-related 0.0019 0.0072 0.0133
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Echinococcus multilocularis potassium channel subfamily K 8 0.002 0.0078 0.0134
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0259 0.0443
Brugia malayi Valyl-tRNA synthetase 0.0011 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0229 0.1654 0.4921
Loa Loa (eye worm) hypothetical protein 0.0096 0.0652 0.1931
Trichomonas vaginalis sugar transporter, putative 0.0098 0.0661 0.2861
Mycobacterium ulcerans sugar transporter 0.0044 0.0259 0.3286
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.0005
Plasmodium falciparum heterochromatin protein 1 0.0011 0.001 0.0005
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0193 0.094
Onchocerca volvulus 0.0044 0.0259 0.1961
Onchocerca volvulus 0.0044 0.0259 0.1961
Schistosoma mansoni glycyl-tRNA synthetase 0.0018 0.0059 0.0107
Echinococcus multilocularis calcium dependent protein kinase 0.009 0.0607 0.104
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.002 0.0078 0.0219
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0193 0.0384
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0101 0.1246
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0036 0.0134
Schistosoma mansoni calcium-activated potassium channel 0.002 0.0078 0.0146
Leishmania major glucose transporter, lmgt1 0.0098 0.0661 0.7048
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.002 0.0078 0.0134
Schistosoma mansoni hypothetical protein 0.0048 0.0285 0.0557
Loa Loa (eye worm) hypothetical protein 0.0156 0.1101 0.3271
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.007 0.0455 0.1343
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0193 0.094
Plasmodium falciparum calcium-dependent protein kinase 3 0.0096 0.0652 0.0648
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.001 0.0005
Schistosoma mansoni calcium-activated potassium channel 0.0156 0.1101 0.2185
Onchocerca volvulus 0.002 0.0078 0.0558
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0193 0.0818
Schistosoma mansoni cpg binding protein 0.003 0.0151 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0064 0.0409 0.1205
Trypanosoma cruzi calcium-activated potassium channel, putative 0.002 0.0078 0.0789
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.1061 0.3152
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.005 0.004
Schistosoma mansoni protein kinase 0.0096 0.0652 0.1289
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.0005
Leishmania major histidyl-tRNA synthetase, putative 0.0011 0.0005 0.0004
Onchocerca volvulus 0.0047 0.0277 0.21
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0043 0.0166
Echinococcus granulosus solute carrier family 22 0.0044 0.0259 0.0515
Toxoplasma gondii sugar transporter ST2 0.0044 0.0259 0.0383
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.007 0.0455 0.6932
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0011
Echinococcus granulosus synaptic vesicle 2 protein 0.0044 0.0259 0.0515
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.201 0.8739
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0005
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0443 0.1307
Schistosoma mansoni chromobox protein 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0228 0.1649 0.4906
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0101 0.1034
Echinococcus granulosus General substrate transporter 0.027 0.1965 0.3913
Schistosoma mansoni hypothetical protein 0.0675 0.5023 1
Plasmodium falciparum protein kinase 7 0.0889 0.6632 0.663
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0229 0.1654 0.4921
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0058 0.0232
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0018 0.0059 0.016
Schistosoma mansoni hypothetical protein 0.0019 0.0072 0.0133
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.001 0.0018
Trypanosoma brucei glucose transporter, putative 0.0098 0.0661 0.8747
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0101 0.0353
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1293 0.5614
Echinococcus multilocularis solute carrier family 22 0.0044 0.0259 0.0444
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Leishmania major threonyl-tRNA synthetase, putative 0.0018 0.0059 0.0576
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0096 0.0652 0.0648
Brugia malayi nuclear hormone receptor 0.0011 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.0005
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.002 0.0078 0.0789
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.007 0.0455 0.5997
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0005
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0372 0.2731 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0101 0.1246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.0005
Trypanosoma cruzi ion transport protein, putative 0.0134 0.0936 1
Leishmania major hypothetical protein, conserved 0.0016 0.0043 0.041
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.002 0.0078 0.0269
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0096 0.0652 0.1117
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.0005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0193 0.056
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Giardia lamblia Hexose transporter 0.0044 0.0259 0.0931
Brugia malayi Cam kinase protein 1 0.0096 0.0652 0.1931
Onchocerca volvulus 0.0044 0.0259 0.1961
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1293 0.5614
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0094 0.0637 0.1887
Echinococcus granulosus solute carrier family 22 0.0044 0.0259 0.0515
Echinococcus granulosus lysyl tRNA synthetase 0.007 0.0455 0.0906
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Echinococcus granulosus RUN 0.0019 0.0072 0.0143
Leishmania major glycyl tRNA synthetase, putative 0.0011 0.0005 0.0004
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.002 0.0078 0.0219
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.006 0.0375 0.2086
Onchocerca volvulus 0.0044 0.0259 0.1961
Entamoeba histolytica hypothetical protein 0.0106 0.0724 0.2636
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0062 0.0615
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0007 0.0003
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.001 0.0007
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0078 0.032
Brugia malayi Doublecortin family protein 0.0019 0.0072 0.0199
Trypanosoma cruzi hexose transporter, putative 0.0044 0.0259 0.2727
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.0005
Trichomonas vaginalis sugar transport protein, putative 0.0044 0.0259 0.1107
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0062 0.021
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0193 0.094
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0072 0.0143
Treponema pallidum glycyl-tRNA synthetase 0.0011 0.0005 0.002
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0022 0.0038
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0285 0.0567
Onchocerca volvulus 0.0012 0.0015 0.0061
Echinococcus granulosus solute carrier family 22 0.0044 0.0259 0.0515
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0018 0.0059 0.2114
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.001 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0193 0.0818
Leishmania major potassium channel subunit-like protein 0.002 0.0078 0.0789
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0007 0.0003
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0094 0.0637 0.126
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.0013
Trichomonas vaginalis sugar transporter, putative 0.0098 0.0661 0.2861
Loa Loa (eye worm) hypothetical protein 0.003 0.0153 0.0441
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0011 0.0005 0.0004
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0101 0.0366
Schistosoma mansoni hypothetical protein 0.0048 0.0285 0.0557
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0127 0.0886 0.1765
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0096 0.0652 0.1931
Plasmodium falciparum calcium-dependent protein kinase 1 0.0096 0.0652 0.0648
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0259 0.0515
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0044 0.0259 0.0506
Toxoplasma gondii glycyl-tRNA synthetase 0.0018 0.0059 0.0081
Schistosoma mansoni glucose transport protein 0.0315 0.2299 0.4572
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.001 0.002
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0229 0.1654 0.2834
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0015
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0094 0.0637 0.1887
Brugia malayi hypothetical protein 0.0228 0.1649 0.4906
Schistosoma mansoni cpg binding protein 0.0028 0.0139 0.0266
Echinococcus granulosus GPCR family 2 0.0048 0.0285 0.0567
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0154
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Schistosoma mansoni threonyl-tRNA synthetase 0.0011 0.0005 0.0001
Plasmodium vivax threonine--tRNA ligase, putative 0.0018 0.0059 0.0054
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Giardia lamblia Prolyl-tRNA synthetase 0.0094 0.0637 0.2319
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0101 0.1246
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0062 0.0615
Echinococcus granulosus calcium activated potassium channel variant 0.002 0.0078 0.0156
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0007 0.0003
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.1649 0.2825
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0043 0.041
Echinococcus multilocularis solute carrier family 22 0.0044 0.0259 0.0444
Trypanosoma brucei glucose transporter 2A 0.0098 0.0661 0.8747
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Mycobacterium ulcerans integral membrane transport protein 0.0044 0.0259 0.3286
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0287
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.001 0.0007
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0016 0.0043 0.0058
Trypanosoma cruzi hexose transporter 0.0098 0.0661 0.7048
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.001 0.0015
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0011 0.0005 0.0014
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0315 0.2299 0.4577
Echinococcus granulosus potassium channel subfamily K 8 0.002 0.0078 0.0156
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.201 0.8739
Chlamydia trachomatis lysine--tRNA ligase 0.007 0.0455 1
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Echinococcus multilocularis solute carrier family 22 0.0044 0.0259 0.0444
Schistosoma mansoni hypothetical protein 0.0047 0.0277 0.0542
Leishmania major glucose transporter, lmgt2 0.0098 0.0661 0.7048
Echinococcus granulosus Chromo domain 0.0011 0.001 0.002
Echinococcus multilocularis small conductance calcium activated potassium 0.0156 0.1101 0.1887
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.001 0.0017
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0072 0.0067
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0193 0.094
Mycobacterium ulcerans ion transport protein 0.0113 0.0778 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0011 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Schistosoma mansoni chromobox protein 0.0011 0.001 0.001
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0443 0.1909
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0011 0.0005 0.001
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.002 0.0078 0.0789
Plasmodium falciparum hexose transporter 0.0315 0.2299 0.2295
Trypanosoma brucei glucose transporter, putative 0.0098 0.0661 0.8747
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Trypanosoma cruzi hexose transporter, putative 0.0098 0.0661 0.7048
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0005
Schistosoma mansoni glucose transporter 0.0044 0.0259 0.0506
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0011 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Mycobacterium ulcerans hypothetical protein 0.0023 0.0101 0.1246
Schistosoma mansoni hypothetical protein 0.0021 0.0083 0.0155
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0018 0.0059 0.2114
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0018 0.0059 0.0197
Onchocerca volvulus 0.0019 0.0072 0.0505
Trypanosoma cruzi hexose transporter, putative 0.0053 0.0328 0.3464
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.001 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Giardia lamblia DNA repair protein RAD52 0.0372 0.2731 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0096 0.0652 0.1931
Loa Loa (eye worm) hypothetical protein 0.0044 0.0259 0.0758
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.201 0.8739
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0127 0.0886 0.263
Echinococcus granulosus twik family of potassium channels 0.002 0.0078 0.0156
Schistosoma mansoni rab6-interacting 0.0019 0.0072 0.0133
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0094 0.0637 0.126
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.001 0.0018
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.002 0.0078 0.0219
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0015
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0018 0.0059 0.0234
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0078 0.032
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0062 0.0615
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.002 0.0078 0.0219
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.005 0.004
Chlamydia trachomatis threonine--tRNA ligase 0.0018 0.0059 0.1193
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0018 0.0059 0.0695
Brugia malayi SET domain containing protein 0.0012 0.0015 0.0028
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0044 0.0259 0.3286
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Toxoplasma gondii sugar transporter ST1 0.0044 0.0259 0.0383
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0018 0.0059 0.0197
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0007 0.0013
Toxoplasma gondii protein kinase, putative 0.0889 0.6632 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0062 0.0057
Toxoplasma gondii anticodon binding domain-containing protein 0.0011 0.0005 0.0001
Brugia malayi CXXC zinc finger family protein 0.0028 0.0139 0.0398
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0276 0.201 0.5982
Plasmodium vivax potassium channel, putative 0.002 0.0078 0.0073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0032 0.0119
Giardia lamblia Lysyl-tRNA synthetase 0.007 0.0455 0.1651
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0193 0.0374
Onchocerca volvulus 0.0044 0.0259 0.1961
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0154
Echinococcus multilocularis potassium channel subfamily K 0.002 0.0078 0.0134
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0011 0.0005 0.0009
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0315 0.2299 0.4577
Brugia malayi ecdysteroid receptor 0.0011 0.0007 0.0005
Plasmodium vivax calcium-dependent protein kinase, putative 0.0096 0.0652 0.0648
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0078 0.0789
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0044 0.0259 0.0444
Schistosoma mansoni hypothetical protein 0.002 0.0078 0.0146
Schistosoma mansoni lipoxygenase 0.0081 0.0538 0.1062
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0018 0.0059 0.0262
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0007 0.0003
Schistosoma mansoni glucose transport protein 0.0315 0.2299 0.4572
Echinococcus granulosus small conductance calcium activated potassium 0.0156 0.1101 0.2193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0259 0.0515
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.001 0.0021
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0011 0.0005 0.0009
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0315 0.2299 0.3939
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0652 0.1289
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0329 0.049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0259 0.0505
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0018 0.0059 0.016
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0096 0.0652 0.1298
Onchocerca volvulus 0.0023 0.0101 0.0735
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.0005
Trichomonas vaginalis glucose transporter, putative 0.0098 0.0661 0.2861
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0193 0.0818
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0062 0.0171
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.001 0.0018
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0078 0.0146
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Mycobacterium ulcerans lysyl-tRNA synthetase 0.007 0.0455 0.5823
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0193 0.0188
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.001 0.0021
Trypanosoma brucei glucose transporter, putative 0.0098 0.0661 0.8747
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0193 0.094
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0193 0.033
Giardia lamblia Glycyl-tRNA synthetase 0.0018 0.0059 0.0197
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.0801 0.1373
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.0661 0.8747
Loa Loa (eye worm) major facilitator superfamily transporter 0.0044 0.0259 0.0758
Mycobacterium tuberculosis Conserved protein 0.0035 0.0193 0.094
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0101 0.0287
Schistosoma mansoni sugar transporter 0.0044 0.0259 0.0506
Schistosoma mansoni sugar transporter 0.0044 0.0259 0.0506
Plasmodium falciparum threonine--tRNA ligase 0.0018 0.0059 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0661 0.2861
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.007 0.0455 0.1962
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0259 0.0505
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0058 0.0232
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0015 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0078 0.0789
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.1366 0.5935
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0013
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0229 0.1654 0.4921
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0007 0.0013
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0062 0.2254
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0011 0.0005 0.0009
Schistosoma mansoni protein kinase 0.0096 0.0652 0.1289
Loa Loa (eye worm) sugar transporter 0.0315 0.2299 0.6845
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0005
Trichomonas vaginalis hypothetical protein 0.0011 0.001 0.0021
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.007 0.0455 0.4833
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.0801 0.1596
Brugia malayi Protein cec-1. 0.0011 0.001 0.0015
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0315 0.2299 0.3939
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Echinococcus multilocularis synaptic vesicle 2 protein 0.0044 0.0259 0.0444
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0127 0.0886 0.1756
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0139 0.0398
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0062 0.021
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0193 0.0818
Onchocerca volvulus 0.002 0.0078 0.0558
Brugia malayi MH2 domain containing protein 0.0118 0.0812 0.2409
Trypanosoma brucei glucose transporter, putative 0.0098 0.0661 0.8747
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0072 0.0123
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0072 0.0143
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.002 0.0078 0.0219
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0059 0.0576
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0043 0.0166
Giardia lamblia Sugar-proton symporter 0.0044 0.0259 0.0931
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0193 0.0818
Loa Loa (eye worm) hypothetical protein 0.0209 0.1501 0.4463
Brugia malayi hypothetical protein 0.0044 0.0259 0.0758
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0259 0.0443
Echinococcus granulosus potassium channel subfamily K 8 0.002 0.0078 0.0156
Plasmodium falciparum proline--tRNA ligase 0.011 0.0755 0.0751
Trypanosoma cruzi ion transport protein, putative 0.0134 0.0936 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.0003
Onchocerca volvulus 0.0011 0.001 0.0025
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0072 0.0123
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0259 0.1107
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0007 0.0005
Echinococcus granulosus Chromobox protein 3 0.0011 0.001 0.002
Leishmania major protein kinase, putative 0.0096 0.0652 0.6948
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.002 0.0078 0.0219
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0043 0.0508
Echinococcus multilocularis geminin 0.0675 0.5023 0.8605
Echinococcus multilocularis GPCR, family 2 0.0048 0.0285 0.0488
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0101 0.0366
Schistosoma mansoni sugar transporter 0.0044 0.0259 0.0506
Plasmodium vivax lysine--tRNA ligase, putative 0.007 0.0455 0.045
Onchocerca volvulus 0.0019 0.0072 0.0505
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0096 0.0652 0.1117
Loa Loa (eye worm) sugar transporter 0.0044 0.0259 0.0758
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0044 0.0259 0.1356
Echinococcus multilocularis histidyl tRNA synthetase 0.0011 0.0005 0.0009
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0011 0.0005 0.0002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0193 0.056
Onchocerca volvulus 0.002 0.0078 0.0558
Loa Loa (eye worm) hypothetical protein 0.0103 0.0702 0.208
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0011 0.0005 0.0001
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0015
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.002 0.0078 0.0219
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0101 0.1246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0058 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0215 0.0917
Plasmodium falciparum potassium channel 0.002 0.0078 0.0073
Brugia malayi CHD4 protein 0.0013 0.0022 0.0051
Treponema pallidum threonyl-tRNA synthetase 0.0018 0.0059 0.3127
Echinococcus granulosus Sugar transporter ERD6 protein 0.0044 0.0259 0.0515
Echinococcus granulosus chromobox protein 1 0.0069 0.0443 0.0882
Plasmodium falciparum mitogen-activated protein kinase 2 0.0508 0.3761 0.3758
Schistosoma mansoni ap endonuclease 0.0018 0.0062 0.0114
Brugia malayi major facilitator superfamily protein 0.0044 0.0259 0.0758
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0193 0.094
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1634 1
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0043 0.041
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0101 0.1246
Toxoplasma gondii exonuclease III APE 0.0018 0.0062 0.0086
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0315 0.2299 0.3939
Echinococcus multilocularis chromobox protein 1 0.0069 0.0443 0.0759
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0378 0.0743
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0007 0.0005
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0018 0.0059 0.0081
Onchocerca volvulus 0.0044 0.0259 0.1961
Loa Loa (eye worm) uncoordinated protein 58 0.002 0.0078 0.0219

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 44.5 % Effect on hematocrit levels in SAD1 mouse model at 20 mg/kg, po bid after 7 days ChEMBL. 18232633
Activity (functional) = 44.5 % Effect on hematocrit levels in SAD1 mouse model at 20 mg/kg, po bid after 7 days ChEMBL. 18232633
Activity (functional) = 47 % Effect on hematocrit levels in SAD1 mouse model at 20 mg/kg, po bid after 14 days ChEMBL. 18232633
Activity (functional) = 47 % Effect on hematocrit levels in SAD1 mouse model at 20 mg/kg, po bid after 14 days ChEMBL. 18232633
Activity (functional) = 27 g/dl Effect on mean corpuscular hemoglobin concentration in SAD1 mouse model at 20 mg/kg, po bid after 14 days ChEMBL. 18232633
Activity (functional) = 27 g/dl Effect on mean corpuscular hemoglobin concentration in SAD1 mouse model at 20 mg/kg, po bid after 14 days ChEMBL. 18232633
Activity (functional) = 34 g/dl Effect on mean corpuscular hemoglobin concentration in SAD1 mouse model at 20 mg/kg, po bid after 7 days ChEMBL. 18232633
Activity (functional) = 34 g/dl Effect on mean corpuscular hemoglobin concentration in SAD1 mouse model at 20 mg/kg, po bid after 7 days ChEMBL. 18232633
Activity (functional) = 2 mmol Effect on gardos channel activity in SAD1 mouse model assessed by measuring [86Rb]/L of cells at 20 mg/kg, po bid after 14 days ChEMBL. 18232633
Activity (functional) = 2 mmol Effect on gardos channel activity in SAD1 mouse model assessed by measuring [86Rb]/L of cells at 20 mg/kg, po bid after 14 days ChEMBL. 18232633
Activity (functional) = 4 mmol Effect on gardos channel activity in SAD1 mouse model assessed by measuring [86Rb]/L of cells at 20 mg/kg, po bid after 7 days ChEMBL. 18232633
Activity (functional) = 4 mmol Effect on gardos channel activity in SAD1 mouse model assessed by measuring [86Rb]/L of cells at 20 mg/kg, po bid after 7 days ChEMBL. 18232633
CL (ADMET) = 40 % Intrinsic clearance in rat liver microsome S9 fraction ChEMBL. 18232633
Cmax (ADMET) = 250 ng/ml Cmax in Sprague-Dawley rat at 1 mg/kg, iv or 10 mg/kg, po ChEMBL. 18232633
F (ADMET) = 35 % Bioavailability in Sprague-Dawley rat at 1 mg/kg, iv or 10 mg/kg, po ChEMBL. 18232633
IC50 (binding) = 9 nM Selectivity of the compound for gardos channel; (Gardos channel vs 2000 nM for the cardiac IKs channel).) ChEMBL. 11356099
IC50 (binding) = 9 nM Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux ChEMBL. 18232633
IC50 (binding) = 9 nM Selectivity of the compound for gardos channel; (Gardos channel vs 2000 nM for the cardiac IKs channel).) ChEMBL. 11356099
IC50 (binding) = 9 nM Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux ChEMBL. 18232633
IC50 (binding) = 2000 nM Inhibition of Iks current KvLQT1 potassium channel ChEMBL. 11356099
IC50 (binding) = 2000 nM Inhibition of Iks current KvLQT1 potassium channel ChEMBL. 11356099
Inhibition (ADMET) < 20 % Inhibition of CYP3A4 (unknown origin) at 10 uM ChEMBL. 18232633
Inhibition (ADMET) < 20 % Inhibition of CYP3A4 (unknown origin) at 10 uM ChEMBL. 18232633
Solubility = 5.8 uM Solubility of the compound by shake-flask method ChEMBL. 18232633
t1/2 (ADMET) = 2.5 hr Half life in Sprague-Dawley rat at 1 mg/kg, iv or 10 mg/kg, po ChEMBL. 18232633
Tmax (ADMET) = 2 hr Tmax in Sprague-Dawley rat at 1 mg/kg, iv or 10 mg/kg, po ChEMBL. 18232633

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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