Detailed information for compound 623230

Basic information

Technical information
  • TDR Targets ID: 623230
  • Name: N-[3-[5-(3-fluorophenyl)-1-propanoyl-4,5-dihy dropyrazol-3-yl]phenyl]methanesulfonamide
  • MW: 389.444 | Formula: C19H20FN3O3S
  • H donors: 1 H acceptors: 3 LogP: 2.24 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)N1N=C(CC1c1cccc(c1)F)c1cccc(c1)NS(=O)(=O)C
  • InChi: 1S/C19H20FN3O3S/c1-3-19(24)23-18(14-7-4-8-15(20)10-14)12-17(21-23)13-6-5-9-16(11-13)22-27(2,25)26/h4-11,18,22H,3,12H2,1-2H3
  • InChiKey: YQQSJHKKLJJWGS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-[5-(3-fluorophenyl)-1-(1-oxopropyl)-4,5-dihydropyrazol-3-yl]phenyl]methanesulfonamide
  • N-[3-[5-(3-fluorophenyl)-1-propionyl-4,5-dihydropyrazol-3-yl]phenyl]methanesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase family protein 0.0071 0.0325 0.1126
Echinococcus granulosus RUN 0.002 0.0025 0.0035
Schistosoma mansoni chromobox protein 0.0068 0.031 0.0431
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0131 0.0741
Schistosoma mansoni peptidase Clp (S14 family) 0.0083 0.0398 0.0554
Brugia malayi jmjC domain containing protein 0.0062 0.0274 0.0947
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0024 0.0081
Loa Loa (eye worm) hypothetical protein 0.0075 0.0352 0.1218
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0307
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0033 0.0084
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0038 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0024 0.0081
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.0398 1
Brugia malayi Importin beta-1 subunit 0.0032 0.0093 0.0323
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0325 0.0878
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0325 0.2045
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0398 0.5
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0025 0.0025
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0105 0.0105
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0075 0.1322
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0093 0.0557
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Onchocerca volvulus 0.002 0.0025 0.0015
Brugia malayi hypothetical protein 0.0075 0.0352 0.1218
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0032 0.0093 0.0557
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Mycobacterium ulcerans beta-lactamase 0.0071 0.0325 0.3871
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0069 0.024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0087 0.0445
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0024 0.0033
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0024 0.0081
Schistosoma mansoni cpg binding protein 0.0091 0.0445 0.0619
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Brugia malayi nuclear receptor NHR-88 0.002 0.0024 0.0081
Onchocerca volvulus 0.0071 0.0325 0.2387
Brugia malayi hypothetical protein 0.0234 0.1299 0.4497
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0049 0.0049
Toxoplasma gondii hypothetical protein 0.0029 0.0075 0.0372
Echinococcus multilocularis RUN 0.002 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0024 0.0081
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0024 0.0033
Schistosoma mansoni coup transcription factor 0.002 0.0024 0.0033
Onchocerca volvulus Huntingtin homolog 0.0121 0.0627 0.4773
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0032 0.0093 0.0557
Schistosoma mansoni hypothetical protein 0.0034 0.0105 0.0146
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.011 0.0563 0.0563
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.031 0.1072
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0024 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1511 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0197 0.0683
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0049 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0065 0.0301
Echinococcus granulosus intermediate filament protein 0.0028 0.007 0.0097
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0024 0.0081
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0172 0.0933 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0325 0.1126
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0959 0.6294
Brugia malayi ecdysteroid receptor 0.002 0.0024 0.0081
Schistosoma mansoni inositol monophosphatase 0.0038 0.0131 0.0182
Loa Loa (eye worm) hypothetical protein 0.0032 0.0093 0.0323
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0044 0.0488
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0044 0.0061
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0032 0.0093 0.1606
Brugia malayi MH2 domain containing protein 0.0355 0.2022 0.7002
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0352 0.8748
Loa Loa (eye worm) hypothetical protein 0.0071 0.0325 0.1126
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0049 0.0068
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0149 0.0862
Loa Loa (eye worm) hypothetical protein 0.0071 0.0325 0.1126
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0093 0.0596
Brugia malayi hypothetical protein 0.0121 0.0627 0.2171
Toxoplasma gondii ABC1 family protein 0.0071 0.0325 0.3367
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0131 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0398 0.5325
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0244 0.034
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0228 0.4744
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0633 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0349 0.1985 0.6873
Onchocerca volvulus 0.0042 0.0155 0.1039
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.05 0.2888 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0325 0.0452
Plasmodium falciparum importin beta, putative 0.0032 0.0093 0.1825
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0032 0.0093 0.0322
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0024 0.0081
Schistosoma mansoni smad1 5 8 and 0.0024 0.0049 0.0068
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0049 0.0068
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0325 0.0878
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.0352 1
Onchocerca volvulus 0.0028 0.007 0.0366
Schistosoma mansoni inositol monophosphatase 0.0038 0.0131 0.0182
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0398 1
Loa Loa (eye worm) hypothetical protein 0.0238 0.1327 0.4594
Loa Loa (eye worm) latrophilin receptor protein 2 0.011 0.0563 0.1949
Schistosoma mansoni hypothetical protein 0.0338 0.1921 0.2671
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0398 0.424
Loa Loa (eye worm) hypothetical protein 0.0071 0.0325 0.1126
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0024 0.0033
Brugia malayi beta-lactamase 0.0071 0.0325 0.1126
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.1299 0.1806
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0024 0.0024
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0032 0.0093 0.0322
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0325 0.2045
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0172 0.0933 0.0933
Entamoeba histolytica hypothetical protein 0.0035 0.0116 0.8298
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0959 0.6294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0024 0.0081
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0325 0.1126
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0024 0.0081
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0024 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0633 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0087 0.0445
Schistosoma mansoni hypothetical protein 0.011 0.0563 0.0782
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0024 0.0081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0024 0.0033
Echinococcus multilocularis dnaJ subfamily B 0.1221 0.7193 0.7193
Schistosoma mansoni thyroid hormone receptor 0.002 0.0024 0.0033
Brugia malayi Inositol-1 0.0038 0.0131 0.0453
Mycobacterium tuberculosis Conserved protein 0.0071 0.0325 0.0878
Brugia malayi Choline O-acetyltransferase 0.0032 0.0093 0.0322
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0032 0.0093 0.0557
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0024 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.2022 0.7002
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0132 0.0746
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1015 0.6675
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0083 0.0398 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0087 0.0445
Echinococcus granulosus tumor protein p63 0.0335 0.1905 0.2648
Brugia malayi hypothetical protein 0.0035 0.0116 0.0402
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1511 1
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0633 0.088
Mycobacterium ulcerans lipase LipD 0.0071 0.0325 0.3871
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0089 0.0538
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0089 0.0089
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0058 0.025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0183 0.0996 0.1385
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0024 0.0024
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0398 0.5325
Echinococcus multilocularis musashi 0.0028 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.05 0.2888 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0024 0.0033
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0398 1
Trichomonas vaginalis set domain proteins, putative 0.0232 0.1288 0.8502
Leishmania major carnitine/choline acetyltransferase, putative 0.0032 0.0093 0.0557
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0116 0.0161
Brugia malayi CXXC zinc finger family protein 0.0086 0.0416 0.1441
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0044 0.0151
Schistosoma mansoni ran 0.0023 0.0044 0.0061
Echinococcus multilocularis tumor protein p63 0.0335 0.1905 0.1905
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0087 0.0445
Onchocerca volvulus 0.002 0.0025 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0088
Trichomonas vaginalis esterase, putative 0.0071 0.0325 0.2045
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0172 0.0933 0.1296
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0089 0.0089
Echinococcus multilocularis choline O acetyltransferase 0.0032 0.0093 0.0093
Echinococcus granulosus choline O acetyltransferase 0.0032 0.0093 0.0129
Schistosoma mansoni choline o-acyltransferase 0.0032 0.0093 0.0129
Brugia malayi steroid hormone receptor 0.002 0.0024 0.0081
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0024 0.0081
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.1299 0.1299
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0093 0.1619
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0058 0.025
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0959 0.6294
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0172 0.0933 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0049 0.0169
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.2022 0.7002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0116 0.0161
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0131 0.0182
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.3974 0.3974
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0228 0.0317
Brugia malayi Smad1 0.0024 0.0049 0.0169
Schistosoma mansoni choline o-acyltransferase 0.0032 0.0093 0.0129
Loa Loa (eye worm) choline O-acetyltransferase 0.0032 0.0093 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0065 0.0301
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0269 0.1511 0.5232
Echinococcus granulosus Smad4 0.0024 0.0049 0.0068
Brugia malayi Pre-SET motif family protein 0.0031 0.0089 0.0307
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0093 0.0557
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0451 0.2593 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0024 0.0024
Onchocerca volvulus 0.0048 0.0189 0.1308
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0024 0.0033
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0044 0.5
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0032 0.0093 0.0557
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0032 0.0093 0.1606
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0024 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0024 0.0081
Schistosoma mansoni nuclear hormone receptor 0.002 0.0024 0.0033
Echinococcus granulosus chromobox protein 1 0.0068 0.031 0.0431
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0131 0.0983
Echinococcus granulosus chromobox protein 1 0.0068 0.031 0.0431
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0044 0.0488
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0325 0.0878
Leishmania major carnitine palmitoyltransferase-like protein 0.0032 0.0093 0.0557
Brugia malayi chromobox protein homolog 3 0.0038 0.0132 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0024 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0089 0.0123
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0069 0.0096
Echinococcus multilocularis Smad4 0.0024 0.0049 0.0049
Schistosoma mansoni rab6-interacting 0.002 0.0025 0.0035
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0025 0.0035
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Onchocerca volvulus 0.0032 0.0093 0.055
Loa Loa (eye worm) hypothetical protein 0.011 0.0563 0.1949
Entamoeba histolytica hypothetical protein 0.0035 0.0116 0.8298
Brugia malayi Heterochromatin protein 1 0.0068 0.031 0.1072
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0093 0.0557
Plasmodium vivax importin-beta 2, putative 0.0032 0.0093 0.1825
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0352 0.3466
Schistosoma mansoni hypothetical protein 0.011 0.0563 0.0782
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0149 0.0992
Schistosoma mansoni hypothetical protein 0.1221 0.7193 1
Echinococcus granulosus importin subunit beta 1 0.0032 0.0093 0.013
Trichomonas vaginalis chromobox protein, putative 0.0068 0.031 0.1941
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.007 0.0242
Mycobacterium ulcerans hypothetical protein 0.0071 0.0325 0.3871
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0325 0.317
Echinococcus granulosus smad 0.0024 0.0049 0.0068
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0352 0.8748
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0349 0.1985 0.6873
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0274 0.038
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0155 0.0215
Schistosoma mansoni intermediate filament proteins 0.0028 0.007 0.0097
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0093 0.1619
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0244 0.0244
Brugia malayi Latrophilin receptor protein 2 0.011 0.0563 0.1949
Schistosoma mansoni hypothetical protein 0.011 0.0563 0.0782
Loa Loa (eye worm) Smad1 0.0024 0.0049 0.0169
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0044 0.0044
Brugia malayi MH1 domain containing protein 0.0024 0.0049 0.0169
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0131 0.0741
Brugia malayi intermediate filament protein 0.0028 0.007 0.0242
Schistosoma mansoni hypothetical protein 0.0238 0.1327 0.1844
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0105 0.0146
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0131 0.1044
Schistosoma mansoni lipoxygenase 0.002 0.0025 0.0035
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0131 0.2835
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Brugia malayi hypothetical protein 0.0048 0.0193 0.0669
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0032 0.0093 0.0557
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0274 0.038
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0352 0.3682
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0959 0.6294
Echinococcus granulosus cpg binding protein 0.0091 0.0445 0.0619
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0352 0.3466
Brugia malayi Choline O-acetyltransferase 0.0032 0.0093 0.0322
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0088
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0107 0.1004
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0633 0.7047
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0067 0.0233
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0069 0.0069
Mycobacterium tuberculosis Conserved protein 0.0071 0.0325 0.0878
Loa Loa (eye worm) hypothetical protein 0.0121 0.0627 0.2171
Echinococcus multilocularis GPCR, family 2 0.011 0.0563 0.0563
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0325 0.2045
Entamoeba histolytica hypothetical protein 0.0035 0.0116 0.8298
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0025 0.0028
Loa Loa (eye worm) hypothetical protein 0.003 0.0083 0.0286
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0024 0.0081
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0038 0.0038
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0131 0.0983
Echinococcus multilocularis smad 0.0024 0.0049 0.0049
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0325 0.3871
Echinococcus multilocularis snurportin 1 0.0338 0.1921 0.1921
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0325 0.8042
Schistosoma mansoni lipoxygenase 0.0057 0.0243 0.0338
Brugia malayi Probable ClpP-like protease 0.0083 0.0398 0.1379
Loa Loa (eye worm) hypothetical protein 0.0121 0.0627 0.2171
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0083 0.0398 0.0554
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0087 0.0445
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0633 1
Schistosoma mansoni cpg binding protein 0.0086 0.0416 0.0579
Brugia malayi Doublecortin family protein 0.002 0.0025 0.0088
Loa Loa (eye worm) doublecortin family protein 0.002 0.0025 0.0088
Plasmodium vivax SET domain protein, putative 0.0031 0.0089 0.1696
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0959 0.6294
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0325 0.0878
Onchocerca volvulus 0.0032 0.0093 0.055
Leishmania major hypothetical protein, conserved 0.0075 0.0352 0.3466
Brugia malayi MH2 domain containing protein 0.0024 0.0049 0.0169
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0083 0.0398 0.0398
Echinococcus multilocularis chromobox protein 1 0.0068 0.031 0.031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.011 0.0563 0.0563
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0033 0.0084
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0083 0.0398 1
Onchocerca volvulus 0.0032 0.0093 0.055
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0325 0.317
Loa Loa (eye worm) CXXC zinc finger family protein 0.0086 0.0416 0.1441
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1511 1
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0325 0.7744
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0024 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0633 0.088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0024 0.0081
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0116 0.0116
Schistosoma mansoni lamin 0.0028 0.007 0.0097
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0032 0.0093 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0024 0.0081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0024 0.0024
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0024 0.0033
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.3974 0.5525
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0035 0.0116 0.0161
Schistosoma mansoni ran 0.0023 0.0044 0.0061
Echinococcus multilocularis chromobox protein 1 0.0068 0.031 0.031
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0024 0.0033
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.011 0.0563 0.0782
Schistosoma mansoni rab6-interacting 0.002 0.0025 0.0035
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0038 0.0053
Schistosoma mansoni smad1 5 8 and 0.0024 0.0049 0.0068
Loa Loa (eye worm) hypothetical protein 0.0071 0.0325 0.1126
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0132 0.0746
Leishmania major importin beta-1 subunit, putative 0.0026 0.0058 0.0159
Leishmania major hypothetical protein, conserved 0.0071 0.0325 0.317
Entamoeba histolytica hypothetical protein 0.0035 0.0116 0.8298
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0087 0.0445
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0089 0.0123
Schistosoma mansoni Smad4 0.0024 0.0049 0.0068
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0132 0.0855
Onchocerca volvulus 0.0086 0.0416 0.3106
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0093 0.0557
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0087 0.0445
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0087 0.0445
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0093 0.0093
Onchocerca volvulus Huntingtin homolog 0.0121 0.0627 0.4773
Schistosoma mansoni importin beta-1 0.0032 0.0093 0.013
Mycobacterium leprae Probable lipase LipE 0.0071 0.0325 0.7744
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0049 0.0068
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0058 0.025
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0024 0.0081
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.011 0.0563 0.0782
Entamoeba histolytica hypothetical protein 0.0026 0.0058 0.162
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1511 1
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1015 0.6675
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0024 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0024 0.0081
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0274 0.0947
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1511 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0025 0.0035
Loa Loa (eye worm) hypothetical protein 0.0083 0.0398 0.1379
Schistosoma mansoni polycystin 1-related 0.002 0.0025 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0024 0.0081
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0633 0.6634
Loa Loa (eye worm) hypothetical protein 0.0032 0.0093 0.0322
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0093 0.0557
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0024 0.0081
Echinococcus granulosus dnaJ subfamily B 0.1221 0.7193 1
Loa Loa (eye worm) inositol-1 0.0038 0.0131 0.0453
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0131 0.0983
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0274 0.038
Brugia malayi jmjC domain containing protein 0.0057 0.0244 0.0846
Onchocerca volvulus 0.003 0.0083 0.0467
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0089 0.0123
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0131 0.0131
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0325 0.2045
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0959 0.6294
Brugia malayi nuclear hormone receptor 0.002 0.0024 0.0081
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0024 0.0033
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0038 0.0053
Schistosoma mansoni smad1 5 8 and 0.0024 0.0049 0.0068
Brugia malayi MH1 domain containing protein 0.0024 0.0049 0.0169
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0025 0.0035
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0325 0.0325
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0089 0.0123
Echinococcus granulosus snurportin 1 0.0338 0.1921 0.2671
Loa Loa (eye worm) hypothetical protein 0.0038 0.0132 0.0456
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0338 0.1921 0.6652
Trichomonas vaginalis chromobox protein, putative 0.0068 0.031 0.1941
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0228 0.0228
Brugia malayi RNA, U transporter 1 0.009 0.0442 0.1529
Brugia malayi Pre-SET motif family protein 0.0204 0.1121 0.3882
Onchocerca volvulus 0.0032 0.0093 0.055
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0243 0.0338
Brugia malayi MH2 domain containing protein 0.0024 0.0049 0.0169
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0325 0.0878
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0025 0.0025
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0024 0.0081
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1121 0.3882
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0325 0.0878
Brugia malayi hypothetical protein 0.002 0.0025 0.0088
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0325 0.1126
Toxoplasma gondii histone lysine methyltransferase SET1 0.0164 0.088 1
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0093 0.1606
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0071 0.0099
Brugia malayi beta-lactamase family protein 0.0071 0.0325 0.1126
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0228 0.0487
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0325 0.0452
Echinococcus granulosus FTZ F1 alpha 0.002 0.0024 0.0033
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0024 0.0033
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0325 0.0452
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0024 0.0081
Onchocerca volvulus 0.0071 0.0325 0.2387
Schistosoma mansoni thyroid hormone receptor 0.002 0.0024 0.0033
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0244 0.034
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0633 0.0633
Echinococcus granulosus GPCR family 2 0.011 0.0563 0.0782
Schistosoma mansoni survival motor neuron protein 0.0048 0.0189 0.0263
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0172 0.0933 1
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0325 0.3871
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0024 0.0081
Onchocerca volvulus Glucosylceramidase homolog 0.0177 0.0959 0.7396
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0032 0.0093 0.1606
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0398 0.424
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.0242
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Loa Loa (eye worm) intermediate filament protein 0.0028 0.007 0.0242
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.011 0.0563 0.1949
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0032 0.0093 0.1606
Onchocerca volvulus 0.0028 0.007 0.0366
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0032 0.0093 0.0322
Loa Loa (eye worm) hypothetical protein 0.0071 0.0325 0.1126
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0032 0.0093 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0024 0.0081
Echinococcus multilocularis lamin dm0 0.0028 0.007 0.007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0024 0.0033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0024 0.0033
Echinococcus multilocularis lamin 0.0028 0.007 0.007
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0352 0.8748
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.007 0.0242
Schistosoma mansoni loxhd1 0.002 0.0025 0.0035
Trichomonas vaginalis ran, putative 0.0023 0.0044 0.0155
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0633 0.088
Loa Loa (eye worm) hypothetical protein 0.0234 0.1299 0.4497
Echinococcus granulosus lamin 0.0028 0.007 0.0097
Loa Loa (eye worm) beta-lactamase 0.0071 0.0325 0.1126
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0032 0.0093 0.0093
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0959 0.6294
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0131 0.0741
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0325 0.0878
Echinococcus multilocularis cpg binding protein 0.0091 0.0445 0.0445
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0024 0.0024
Brugia malayi latrophilin 2 splice variant baaae 0.0238 0.1327 0.4594
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0024 0.0081
Schistosoma mansoni lamin 0.0028 0.007 0.0097
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0243 0.0243
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0269 0.1511 0.5232
Echinococcus granulosus microtubule associated protein 2 0.0682 0.3974 0.5525
Schistosoma mansoni smad 0.0024 0.0049 0.0068
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0058 0.0159
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0325 0.2045
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0032 0.0093 0.0557
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0075 0.1322
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1511 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0038 0.0053
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0189 0.0654
Onchocerca volvulus 0.0071 0.0325 0.2387
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0325 0.9145
Onchocerca volvulus 0.0232 0.1288 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0398 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0349 0.1985 0.6873
Brugia malayi hypothetical protein 0.002 0.0025 0.0088
Loa Loa (eye worm) hypothetical protein 0.0027 0.0067 0.0231
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0024 0.0024
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0633 0.2116
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0197 0.0274
Schistosoma mansoni cpg binding protein 0.0091 0.0445 0.0619
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0228 0.0487
Echinococcus granulosus lamin dm0 0.0028 0.007 0.0097
Schistosoma mansoni chromobox protein 0.0068 0.031 0.0431
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0025 0.0025
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0244 0.0244
Schistosoma mansoni hypothetical protein 0.011 0.0563 0.0782
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0024 0.0033
Onchocerca volvulus 0.0049 0.0197 0.1374
Schistosoma mansoni hypothetical protein 0.002 0.0025 0.0035
Schistosoma mansoni hypothetical protein 0.0048 0.0189 0.0263
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0149 0.0862
Loa Loa (eye worm) hypothetical protein 0.0349 0.1985 0.6873
Mycobacterium tuberculosis Conserved protein 0.0071 0.0325 0.0878
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0044 0.0151

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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