Detailed information for compound 649006

Basic information

Technical information
  • TDR Targets ID: 649006
  • Name: 1-(naphthalen-1-ylmethyl)-4-(4-nitrophenyl)su lfonylpiperazine
  • MW: 411.474 | Formula: C21H21N3O4S
  • H donors: 0 H acceptors: 4 LogP: 3.45 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)Cc1cccc2c1cccc2
  • InChi: 1S/C21H21N3O4S/c25-24(26)19-8-10-20(11-9-19)29(27,28)23-14-12-22(13-15-23)16-18-6-3-5-17-4-1-2-7-21(17)18/h1-11H,12-16H2
  • InChiKey: XDTHRGFNNSRKER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(1-naphthylmethyl)-4-(4-nitrophenyl)sulfonyl-piperazine
  • 1-(1-naphthylmethyl)-4-(4-nitrophenyl)sulfonylpiperazine
  • 1-(naphthalen-1-ylmethyl)-4-(4-nitrophenyl)sulfonyl-piperazine
  • Oprea1_427590
  • STK194479
  • 1-Naphthalen-1-ylmethyl-4-(4-nitro-benzenesulfonyl)-piperazine
  • BAS 03152316
  • Oprea1_750196

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ubiquitin specific protease 41 0.0105 0.0487 0.0484
Mycobacterium leprae putative cytochrome p450 0.0107 0.0502 0.429
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0107 0.0502 0.429
Onchocerca volvulus Glucosylceramidase homolog 0.0496 0.3126 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0107 0.0502 0.5419
Trichomonas vaginalis glucosylceramidase, putative 0.0755 0.4878 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0107 0.0502 0.429
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0105 0.0487 0.0385
Echinococcus multilocularis lipoxygenase domain containing protein 0.0056 0.0161 0.0158
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0702 0.4515 1
Echinococcus granulosus dual specificity protein kinase clk2 0.0702 0.4515 0.4514
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0063 0.0209 0.2115
Trypanosoma brucei cytochrome P450, putative 0.0167 0.0908 0.1623
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0021 0.0044
Schistosoma mansoni cpg binding protein 0.0112 0.0539 0.0438
Onchocerca volvulus 0.0056 0.0156 0.0433
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0105 0.0487 0.0484
Echinococcus multilocularis dual specificity protein kinase clk2 0.0702 0.4515 0.4514
Leishmania major cytochrome p450-like protein 0.0107 0.0502 0.068
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0107 0.0502 0.5419
Echinococcus granulosus lipoxygenase domain containing protein 0.0056 0.0161 0.0158
Brugia malayi cytoplasmic intermediate filament protein 0.0039 0.0045 0.0093
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0107 0.0502 0.068
Loa Loa (eye worm) hypothetical protein 0.006 0.0187 0.0377
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0165 0.0891 1
Onchocerca volvulus 0.0225 0.1303 0.4127
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0107 0.0502 0.5419
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.0811 0.0712
Schistosoma mansoni hypothetical protein 0.0056 0.0156 0.0051
Echinococcus multilocularis 0.0107 0.0502 0.0499
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0105 0.0487 0.0484
Brugia malayi Protein kinase domain containing protein 0.0352 0.2158 0.4423
Trichomonas vaginalis glucosylceramidase, putative 0.0496 0.3126 0.6009
Trypanosoma cruzi cytochrome P450, putative 0.0167 0.0908 0.1045
Echinococcus granulosus microtubule associated protein 2 0.0795 0.5147 0.5146
Loa Loa (eye worm) hypothetical protein 0.0034 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0073 0.0274 0.0557
Echinococcus granulosus dual specificity 0.0352 0.2158 0.2156
Schistosoma mansoni hypothetical protein 0.1514 1 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0107 0.0502 0.429
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0211 0.1205 0.1202
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0107 0.0502 0.5419
Plasmodium vivax serine/threonine kinase-1, putative 0.0702 0.4515 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0107 0.0502 0.5419
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0107 0.0502 0.429
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0107 0.0502 0.5419
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0811 0.0738
Onchocerca volvulus 0.0073 0.0274 0.0815
Trypanosoma brucei protein kinase, putative 0.0153 0.0811 0.1398
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0107 0.0502 0.5419
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0352 0.2158 0.4526
Loa Loa (eye worm) hypothetical protein 0.0056 0.0161 0.0325
Loa Loa (eye worm) CXXC zinc finger family protein 0.0106 0.0498 0.1016
Echinococcus multilocularis lamin dm0 0.0073 0.0274 0.0272
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0352 0.2158 0.4149
Schistosoma mansoni cpg binding protein 0.0112 0.0539 0.0438
Echinococcus granulosus mitogen activated protein kinase 3 0.0153 0.0811 0.0808
Entamoeba histolytica protein kinase, putative 0.0352 0.2158 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0153 0.0811 0.1398
Echinococcus multilocularis Polycystic kidney disease protein 0.0056 0.0161 0.0158
Echinococcus granulosus single minded 2 0.0036 0.0021 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0496 0.3126 0.6009
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0153 0.0811 0.0804
Brugia malayi hypothetical protein 0.0056 0.0161 0.0331
Loa Loa (eye worm) hypothetical protein 0.0272 0.162 0.3316
Loa Loa (eye worm) hypothetical protein 0.0072 0.0265 0.0539
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0107 0.0502 0.429
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0035 0.0019 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.3306 0.6419
Echinococcus multilocularis ubiquitin specific protease 41 0.0105 0.0487 0.0484
Loa Loa (eye worm) intermediate filament protein 0.0073 0.0274 0.0557
Brugia malayi Intermediate filament tail domain containing protein 0.0073 0.0274 0.0563
Entamoeba histolytica hypothetical protein 0.0352 0.2158 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0107 0.0502 0.5419
Loa Loa (eye worm) hypothetical protein 0.0034 0.001 0.0015
Schistosoma mansoni intermediate filament proteins 0.0073 0.0274 0.017
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0107 0.0502 0.5419
Echinococcus multilocularis dnaJ subfamily B 0.1514 1 1
Brugia malayi cytochrome P450 0.0107 0.0502 0.1028
Loa Loa (eye worm) hypothetical protein 0.0693 0.4458 0.9138
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0107 0.0502 0.5419
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.3306 0.6419
Schistosoma mansoni lamin 0.0073 0.0274 0.017
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0107 0.0502 0.5419
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0107 0.0502 0.0037
Schistosoma mansoni survival motor neuron protein 0.0056 0.0156 0.0051
Giardia lamblia Kinase, CMGC CLK 0.0702 0.4515 1
Echinococcus multilocularis musashi 0.0073 0.0274 0.0272
Echinococcus multilocularis L aminoadipate semialdehyde 0.0225 0.1303 0.13
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.0787 0.1608
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0107 0.0502 0.5419
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.2054 0.3568
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0226 0.1303 0.121
Loa Loa (eye worm) hypothetical protein 0.0225 0.1303 0.2666
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0702 0.4515 0.9255
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0702 0.4515 1
Brugia malayi CXXC zinc finger family protein 0.0106 0.0498 0.1022
Entamoeba histolytica protein kinase, putative 0.0352 0.2158 1
Schistosoma mansoni loxhd1 0.0056 0.0161 0.0056
Trichomonas vaginalis glucosylceramidase, putative 0.0496 0.3126 0.6009
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0107 0.0502 0.0037
Loa Loa (eye worm) cytochrome P450 family protein 0.0167 0.0908 0.1856
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0352 0.2158 0.4526
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0107 0.0502 0.5419
Echinococcus multilocularis microtubule associated protein 2 0.0795 0.5147 0.5146
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0107 0.0502 0.429
Trichomonas vaginalis glucosylceramidase, putative 0.0755 0.4878 1
Brugia malayi hypothetical protein 0.0272 0.162 0.332
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0107 0.0502 0.429
Schistosoma mansoni polycystin 1-related 0.0056 0.0161 0.0056
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0107 0.0502 0.5419
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0033
Trypanosoma cruzi cytochrome P450, putative 0.0167 0.0908 0.1045
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0107 0.0502 0.429
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.2054 0.3568
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0811 0.0738
Schistosoma mansoni hypothetical protein 0.0107 0.0502 0.04
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0153 0.0811 0.0804
Schistosoma mansoni lipoxygenase 0.0109 0.052 0.0418
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0107 0.0502 0.0037
Entamoeba histolytica protein kinase domain containing protein 0.0352 0.2158 1
Brugia malayi Cytochrome P450 family protein 0.0107 0.0502 0.1028
Leishmania major protein kinase, putative 0.0702 0.4515 1
Schistosoma mansoni lamin 0.0073 0.0274 0.017
Echinococcus granulosus lamin dm0 0.0073 0.0274 0.0272
Trichomonas vaginalis glucosylceramidase, putative 0.0496 0.3126 0.6009
Echinococcus granulosus cpg binding protein 0.0112 0.0539 0.0537
Loa Loa (eye worm) follicle stimulating hormone receptor 0.073 0.471 0.9655
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0105 0.0487 0.0998
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0063 0.0209 0.5
Echinococcus granulosus RUN 0.0056 0.0161 0.0158
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0337 0.2054 0.9465
Loa Loa (eye worm) hypothetical protein 0.0056 0.0161 0.0325
Echinococcus granulosus hypothetical protein 0.0693 0.4458 0.4457
Brugia malayi Cytochrome P450 family protein 0.0167 0.0908 0.186
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0039 0.0045 0.0087
Leishmania major protein kinase, putative 0.0702 0.4515 1
Brugia malayi Cytochrome P450 family protein 0.029 0.1735 0.3556
Brugia malayi PAS domain containing protein 0.0048 0.0106 0.0217
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.2054 0.3568
Echinococcus granulosus Polycystic kidney disease protein 0.0056 0.0161 0.0158
Brugia malayi Cytochrome P450 family protein 0.0167 0.0908 0.186
Brugia malayi follicle stimulating hormone receptor 0.073 0.471 0.9655
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0073 0.0274 0.0557
Echinococcus multilocularis lipoxygenase domain containing protein 0.0056 0.0161 0.0158
Loa Loa (eye worm) hypothetical protein 0.0344 0.2101 0.4304
Loa Loa (eye worm) cytochrome P450 family protein 0.029 0.1735 0.3553
Schistosoma mansoni cytochrome P450 0.0107 0.0502 0.04
Echinococcus granulosus lamin 0.0073 0.0274 0.0272
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0337 0.2054 0.9465
Onchocerca volvulus 0.0056 0.0161 0.0451
Echinococcus granulosus intermediate filament protein 0.0073 0.0274 0.0272
Schistosoma mansoni microtubule-associated protein tau 0.0795 0.5147 0.5095
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.2054 0.3568
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0107 0.0502 0.429
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0107 0.0502 0.429
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0107 0.0502 0.429
Loa Loa (eye worm) cytochrome P450 0.0107 0.0502 0.1023
Trichomonas vaginalis glucosylceramidase, putative 0.0496 0.3126 0.6009
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0105 0.0487 0.1425
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0107 0.0502 0.429
Trichomonas vaginalis glucosylceramidase, putative 0.0755 0.4878 1
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0811 0.0738
Echinococcus multilocularis dual specificity 0.0352 0.2158 0.2156
Giardia lamblia Fructose-bisphosphate aldolase 0.0337 0.2054 0.389
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0811 0.0738
Leishmania major cytochrome p450-like protein 0.0107 0.0502 0.068
Loa Loa (eye worm) doublecortin family protein 0.0056 0.0161 0.0325
Loa Loa (eye worm) hypothetical protein 0.0344 0.2101 0.4304
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0755 0.4878 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0107 0.0502 0.5419
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0153 0.0811 0.1398
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0352 0.2158 0.442
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0021 0.0019
Onchocerca volvulus 0.0073 0.0274 0.0815
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0702 0.4515 1
Brugia malayi MAP kinase sur-1 0.0153 0.0811 0.1662
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.2054 0.3568
Echinococcus granulosus lipoxygenase domain containing protein 0.0056 0.0161 0.0158
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0107 0.0502 0.5419
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0165 0.0891 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0153 0.0811 0.0808
Toxoplasma gondii histone lysine methyltransferase SET1 0.0201 0.114 0.2163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.2054 0.3568
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0107 0.0502 0.429
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0107 0.0502 0.068
Trichomonas vaginalis glucosylceramidase, putative 0.0755 0.4878 1
Echinococcus granulosus mitogen activated protein kinase 0.0153 0.0811 0.0808
Echinococcus granulosus L aminoadipate semialdehyde 0.0225 0.1303 0.13
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0165 0.0891 0.9814
Trichomonas vaginalis glucosylceramidase, putative 0.0755 0.4878 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0153 0.0811 0.1398
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0156 0.032
Schistosoma mansoni rab6-interacting 0.0056 0.0161 0.0056
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0107 0.0502 0.429
Brugia malayi Doublecortin family protein 0.0056 0.0161 0.0331
Echinococcus granulosus cytochrome P450 2K1 0.0107 0.0502 0.0499
Treponema pallidum fructose-bisphosphate aldolase 0.0337 0.2054 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0153 0.0811 0.0804
Onchocerca volvulus 0.0056 0.0161 0.0451
Echinococcus multilocularis cpg binding protein 0.0112 0.0539 0.0537
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0153 0.0811 0.0804
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0063 0.0209 0.0109
Echinococcus multilocularis RUN 0.0056 0.0161 0.0158
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0063 0.0209 0.0109
Brugia malayi hypoxia-induced factor 1 0.0149 0.0787 0.1613
Brugia malayi intermediate filament protein 0.0073 0.0274 0.0563
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0107 0.0502 0.429
Schistosoma mansoni serine/threonine protein kinase 0.0702 0.4515 0.4457
Schistosoma mansoni serine/threonine protein kinase 0.0702 0.4515 0.4457
Brugia malayi hypothetical protein 0.0162 0.0871 0.1786
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0105 0.0487 0.0484
Trichomonas vaginalis glucosylceramidase, putative 0.0496 0.3126 0.6009
Echinococcus granulosus survival motor neuron protein 1 0.0272 0.162 0.1617
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0702 0.4515 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0107 0.0502 0.429
Brugia malayi hypothetical protein 0.0056 0.0161 0.0331
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0702 0.4515 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0225 0.1303 0.267
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0167 0.0908 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0225 0.1303 0.121
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0702 0.4515 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0167 0.0908 0.1856
Brugia malayi Protein kinase domain containing protein 0.0702 0.4515 0.9255
Schistosoma mansoni rab6-interacting 0.0056 0.0161 0.0056
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0063 0.0209 0.2115
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0105 0.0487 0.0385
Loa Loa (eye worm) CYP4Cod1 0.0167 0.0908 0.1856
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0107 0.0502 0.5419
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0105 0.0487 0.0484
Schistosoma mansoni hypothetical protein 0.0056 0.0161 0.0056
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0107 0.0502 0.5419
Echinococcus multilocularis lamin 0.0073 0.0274 0.0272
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0035 0.0019 0.0016
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0107 0.0502 0.5419
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0107 0.0502 0.429
Schistosoma mansoni cpg binding protein 0.0106 0.0498 0.0397
Loa Loa (eye worm) hypothetical protein 0.0105 0.0487 0.0992
Loa Loa (eye worm) hypothetical protein 0.0162 0.0871 0.1781
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0107 0.0502 0.429
Mycobacterium leprae Conserved hypothetical protein 0.0107 0.0502 0.429
Trichomonas vaginalis glucosylceramidase, putative 0.0496 0.3126 0.6009
Echinococcus multilocularis mitogen activated protein kinase 0.0153 0.0811 0.0808
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0107 0.0502 0.5419
Trichomonas vaginalis CMGC family protein kinase 0.0702 0.4515 0.9173
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0702 0.4515 1
Plasmodium falciparum protein serine/threonine kinase-1 0.0702 0.4515 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0063 0.0209 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.2054 0.3568
Leishmania major cytochrome p450-like protein 0.0167 0.0908 0.1623
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0755 0.4878 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0107 0.0502 0.068
Onchocerca volvulus 0.0106 0.0498 0.1537
Schistosoma mansoni serine/threonine protein kinase 0.0352 0.2158 0.2074
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0105 0.0487 0.0645
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0107 0.0502 0.429
Schistosoma mansoni lipoxygenase 0.0211 0.1205 0.111
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0105 0.0487 0.0645
Echinococcus multilocularis 0.0693 0.4458 0.4457
Echinococcus multilocularis survival motor neuron protein 1 0.0272 0.162 0.1617
Giardia lamblia Kinase, CMGC MAPK 0.0153 0.0811 0.0804
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0352 0.2158 0.4149
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0211 0.1205 0.1202
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0153 0.0811 0.1398
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.2054 0.3568
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0107 0.0502 0.429
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0153 0.0811 0.1657
Trichomonas vaginalis glucosylceramidase, putative 0.0755 0.4878 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.