Detailed information for compound 657280

Basic information

Technical information
  • TDR Targets ID: 657280
  • Name: 4-bromo-N-(6-methyl-2-phenylbenzotriazol-5-yl )benzamide
  • MW: 407.263 | Formula: C20H15BrN4O
  • H donors: 1 H acceptors: 3 LogP: 5.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)C(=O)Nc1cc2nn(nc2cc1C)c1ccccc1
  • InChi: 1S/C20H15BrN4O/c1-13-11-18-19(24-25(23-18)16-5-3-2-4-6-16)12-17(13)22-20(26)14-7-9-15(21)10-8-14/h2-12H,1H3,(H,22,26)
  • InChiKey: YMSBJNLDDKHUSM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-bromo-N-(6-methyl-2-phenyl-benzotriazol-5-yl)benzamide
  • 4-bromo-N-(6-methyl-2-phenyl-5-benzotriazolyl)benzamide
  • BIM-0012717.P001
  • AG-670/14742022
  • CBMicro_012715
  • ZINC00722906
  • EU-0040986

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0038 0.0038 0.0653
Mycobacterium tuberculosis Conserved protein 0.0038 0.0038 0.0106
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0404 0.0671 0.1893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0135
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0016 0.0578
Echinococcus multilocularis musashi 0.003 0.0024 0.0024
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0055 0.0068 0.019
Toxoplasma gondii hypothetical protein 0.0057 0.007 0.2509
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0038 0.0875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0037 0.0848
Toxoplasma gondii target of rapamycin (TOR), putative 0.0037 0.0037 0.1312
Echinococcus multilocularis ferritin 0.0018 0.0003 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.0064 0.0179
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0016 0.0016
Echinococcus granulosus cysteine protease 0.002 0.0006 0.0006
Echinococcus multilocularis thyroid hormone receptor alpha 0.0138 0.0211 0.0211
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0076 0.1311
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0224 0.3856
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0041 0.0953
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0038 0.0875
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0053 0.0064 0.0179
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.004 0.004 0.1619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0019 0.0436
Onchocerca volvulus 0.0053 0.0064 0.1121
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0061 0.0078 0.1346
Toxoplasma gondii cathepsin CPL 0.0038 0.0038 0.136
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0404 0.0671 0.1893
Entamoeba histolytica cysteine protease, putative 0.002 0.0006 0.0346
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0061 0.0078 0.2803
Brugia malayi Probable ClpP-like protease 0.0161 0.025 0.3097
Echinococcus multilocularis cathepsin L 0.002 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0041 0.0953
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0045 0.005 0.0618
Entamoeba histolytica cysteine protease, putative 0.002 0.0006 0.0346
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0006 0.0346
Entamoeba histolytica cysteine protease, putative 0.002 0.0006 0.0346
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.003 0.003
Schistosoma mansoni ferritin light chain 0.0018 0.0003 0.0003
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0061 0.0078 0.2803
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0004 0.0004
Loa Loa (eye worm) fibroinase 0.0038 0.0038 0.0469
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0061 0.0078 0.2803
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0006 0.0006
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0038 0.0467
Echinococcus granulosus smad 0.0018 0.0003 0.0003
Leishmania major cathepsin L-like protease 0.0146 0.0224 0.3856
Loa Loa (eye worm) hypothetical protein 0.0199 0.0317 0.3925
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0037 0.0104
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0016 0.0278
Loa Loa (eye worm) hypothetical protein 0.0053 0.0064 0.0789
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0038 0.088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0038 0.088
Entamoeba histolytica hypothetical protein 0.0114 0.0168 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0003 0.0003
Entamoeba histolytica cysteine protease, putative 0.002 0.0006 0.0346
Leishmania major cathepsin L-like protease 0.0038 0.0038 0.0653
Entamoeba histolytica cysteine protease, putative 0.002 0.0006 0.0346
Plasmodium falciparum thioredoxin reductase 0.0061 0.0078 0.2803
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.004 0.0501
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0501
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0064 0.0789
Echinococcus granulosus expressed protein 0.0018 0.0003 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0037 0.0104
Loa Loa (eye worm) RNA binding protein 0.0064 0.0083 0.1031
Entamoeba histolytica hypothetical protein 0.0114 0.0168 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.003 0.003
Brugia malayi Smad1 0.0018 0.0003 0.004
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.005 0.0059 0.1015
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0061 0.0078 0.0078
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.005 0.0059 0.0729
Leishmania major trypanothione reductase 0.0177 0.0278 0.4803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.003 0.0701
Loa Loa (eye worm) hypothetical protein 0.0053 0.0064 0.0789
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0083 0.0083
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0083 0.1031
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0003 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0038 0.088
Echinococcus granulosus cathepsin l1 0.0026 0.0016 0.0016
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0013 0.0223
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.003 0.1063
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0008 0.0137
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0064 0.0789
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0224 0.3856
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0038 0.065
Entamoeba histolytica cysteine protease, putative 0.002 0.0006 0.0346
Loa Loa (eye worm) hypothetical protein 0.003 0.0024 0.0298
Onchocerca volvulus 0.0038 0.0038 0.0667
Brugia malayi hypothetical protein 0.0483 0.0807 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0161 0.025 1
Schistosoma mansoni Smad4 0.0018 0.0003 0.0003
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0006 0.0101
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0061 0.0078 0.1346
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0166 0.026 0.4476
Loa Loa (eye worm) transcription factor SMAD2 0.0267 0.0433 0.5366
Mycobacterium ulcerans hypothetical protein 0.0053 0.0064 0.0179
Mycobacterium ulcerans AcrR family transcriptional regulator 0.207 0.3552 1
Onchocerca volvulus Cathepsin F homolog 0.0038 0.0038 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0038 0.088
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.005 0.0059 0.3491
Brugia malayi glutathione reductase 0.0177 0.0278 0.3452
Onchocerca volvulus 0.0265 0.0431 0.7579
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0038 0.0667
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0038 0.088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0224 0.3856
Onchocerca volvulus 0.0033 0.003 0.0521
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0038 0.088
Brugia malayi beta-lactamase family protein 0.0038 0.0038 0.0467
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.005 0.0059 0.1015
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0003 0.0003
Plasmodium vivax vivapain-3 0.002 0.0006 0.0209
Entamoeba histolytica cysteine protease, putative 0.002 0.0006 0.0346
Brugia malayi MH2 domain containing protein 0.0018 0.0003 0.004
Entamoeba histolytica cysteine protease, putative 0.002 0.0006 0.0346
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0003 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0224 0.3856
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0023 0.0541
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.002 0.0006 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0001 0.0023
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.026 0.4476
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0061 0.0078 0.1346
Schistosoma mansoni smad1 5 8 and 0.0018 0.0003 0.0003
Echinococcus granulosus lamin dm0 0.003 0.0024 0.0024
Brugia malayi RNA binding protein 0.0064 0.0083 0.1031
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.0193 0.0193
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0061 0.0078 0.3124
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0006 0.0101
Loa Loa (eye worm) cysteine protease 0.0038 0.0038 0.0469
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0064 0.1098
Loa Loa (eye worm) thioredoxin reductase 0.0177 0.0278 0.3452
Plasmodium falciparum glutathione reductase 0.0177 0.0278 1
Leishmania major cathepsin L-like protease 0.0038 0.0038 0.0653
Echinococcus granulosus peptidase Clp S14 family 0.0105 0.0154 0.0154
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0078 0.1346
Onchocerca volvulus 0.0038 0.0038 0.0663
Schistosoma mansoni ferritin 0.0018 0.0003 0.0003
Echinococcus multilocularis lamin dm0 0.003 0.0024 0.0024
Brugia malayi MH1 domain containing protein 0.0018 0.0003 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0224 0.3856
Brugia malayi MH1 domain containing protein 0.0018 0.0003 0.004
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.005 0.0059 0.1015
Brugia malayi MH2 domain containing protein 0.0018 0.0003 0.004
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0038 0.0038
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2066 0.3545 1
Brugia malayi Cathepsin L-like precursor 0.0038 0.0038 0.0469
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0064 0.0179
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0064 0.018
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0161 0.025 0.0703
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0006 0.0101
Onchocerca volvulus 0.0038 0.0038 0.0667
Toxoplasma gondii NADPH-glutathione reductase 0.0061 0.0078 0.2803
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0016 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0038 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0059 0.1366
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0161 0.025 1
Plasmodium vivax vivapain-2 0.0038 0.0038 0.136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0037 0.0104
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.003 0.003
Brugia malayi Cathepsin L-like cysteine proteinase 0.0026 0.0016 0.0199
Loa Loa (eye worm) Smad1 0.0018 0.0003 0.004
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0061 0.0078 0.3124
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0038 0.0038 0.0469
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0199
Echinococcus granulosus thioredoxin glutathione reductase 0.0178 0.028 0.028
Toxoplasma gondii thioredoxin reductase 0.0177 0.0278 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0061 0.0078 0.2803
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0037 0.0104
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0199
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0161 0.025 0.8974
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0016 0.0278
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0001 0.0012
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0061 0.0078 0.0078
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0038 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0041 0.0953
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0352 0.058 1
Plasmodium vivax acyl-CoA synthetase, putative 0.004 0.004 0.1453
Plasmodium vivax vivapain-1 0.002 0.0006 0.0209
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0061 0.0078 0.0078
Leishmania major cathepsin L-like protease 0.0146 0.0224 0.3856
Brugia malayi Pre-SET motif family protein 0.0233 0.0375 0.4647
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0038 0.2247
Loa Loa (eye worm) hypothetical protein 0.0038 0.0038 0.0467
Echinococcus granulosus ferritin 0.0018 0.0003 0.0003
Trypanosoma cruzi target of rapamycin kinase 3 0.004 0.0041 0.0709
Echinococcus granulosus cathepsin L cysteine proteinase 0.0038 0.0038 0.0038
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0061 0.0078 0.022
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0072 0.0894
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0038 0.0106
Loa Loa (eye worm) hypothetical protein 0.0038 0.0038 0.0467
Brugia malayi hypothetical protein 0.0114 0.0168 0.2089
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0053 0.0064 0.0179
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0003 0.004
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0001 0.0017
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0061 0.0078 0.022
Brugia malayi cathepsin L-like precursor 0.0026 0.0016 0.0199
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0064 0.0789
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0501
Mycobacterium tuberculosis Probable reductase 0.0404 0.0671 0.1893
Brugia malayi Cathepsin L-like precursor 0.0026 0.0016 0.0199
Onchocerca volvulus 0.0038 0.0038 0.0667
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0061 0.0078 0.1346
Echinococcus granulosus Smad4 0.0018 0.0003 0.0003
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.005 0.0059 0.1015
Brugia malayi Cathepsin L-like precursor 0.0038 0.0038 0.0469
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0038 0.0106
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0038 0.0106
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0001 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0024 0.0553
Schistosoma mansoni hypothetical protein 0.0018 0.0004 0.0004
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0003 0.0118
Brugia malayi Pre-SET motif family protein 0.0033 0.003 0.0367
Echinococcus multilocularis survival motor neuron protein 1 0.0483 0.0807 0.0807
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0038 0.0038
Brugia malayi Cathepsin L-like precursor 0.0038 0.0038 0.0469
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0083 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0019 0.0436
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0016 0.0951
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0003 0.0008
Plasmodium falciparum glutathione reductase 0.0061 0.0078 0.2803
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0038 0.088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0078 0.1346
Loa Loa (eye worm) hypothetical protein 0.0345 0.0568 0.7042
Schistosoma mansoni thyroid hormone receptor 0.0138 0.0211 0.0211
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.0064 0.378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0038 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0024 0.0553
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0083 0.0083
Loa Loa (eye worm) intermediate filament protein 0.003 0.0024 0.0298
Onchocerca volvulus 0.003 0.0024 0.0423
Schistosoma mansoni thyroid hormone receptor 0.0138 0.0211 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0037 0.0848
Echinococcus granulosus cathepsin l1 0.0038 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0038 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0037 0.0848
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0037 0.0848
Loa Loa (eye worm) hypothetical protein 0.0038 0.0038 0.0467
Schistosoma mansoni intermediate filament proteins 0.003 0.0024 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0064 0.0179
Mycobacterium ulcerans beta-lactamase 0.0038 0.0038 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0041 0.0953
Entamoeba histolytica acyl-coA synthetase, putative 0.0053 0.0064 0.378
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0038 0.0106
Echinococcus multilocularis peptidase Clp (S14 family) 0.0105 0.0154 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0028 0.0657
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0038 0.0469
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0072 0.0894
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0003 0.0118
Loa Loa (eye worm) hypothetical protein 0.0038 0.0038 0.0467
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0001 0.0017
Onchocerca volvulus 0.0345 0.0568 1
Schistosoma mansoni lamin 0.003 0.0024 0.0024
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0061 0.0078 0.1346
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0078 0.1346
Entamoeba histolytica cysteine proteinase 2 0.002 0.0006 0.0346
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0064 0.0179
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0016 0.0578
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0061 0.0078 0.1346
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.0064 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0041 0.0953
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0023 0.0541
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0038 0.0038
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.003 0.003
Entamoeba histolytica cysteine protease, putative 0.002 0.0006 0.0346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0372
Mycobacterium ulcerans fatty-acid-CoA ligase 0.004 0.004 0.0114
Brugia malayi beta-lactamase 0.0038 0.0038 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0024 0.0553
Brugia malayi intermediate filament protein 0.003 0.0024 0.0298
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0038 0.0875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0001 0.0023
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0038 0.0038 0.136
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0038 0.0467
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0006 0.0135
Echinococcus multilocularis expressed protein 0.0018 0.0003 0.0003
Trypanosoma brucei target of rapamycin kinase 3, putative 0.004 0.0041 0.0709
Plasmodium vivax thioredoxin reductase, putative 0.0177 0.0278 1
Brugia malayi Cathepsin L-like precursor 0.0026 0.0016 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0038 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0037 0.0848
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.003 0.003
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0045 0.005 0.0618
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0038 0.088
Onchocerca volvulus 0.0038 0.0038 0.0667
Mycobacterium ulcerans lipase LipD 0.0038 0.0038 0.0106
Entamoeba histolytica cysteine protease, putative 0.002 0.0006 0.0346
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0224 0.3856
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0083 0.1031
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.005 0.0059 0.0059
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0105 0.0154 0.0435
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0001 0.0001
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.0393 0.1108
Schistosoma mansoni hypothetical protein 0.0128 0.0193 0.0193
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0161 0.025 0.8974
Trypanosoma brucei trypanothione reductase 0.0177 0.0278 0.4803
Trichomonas vaginalis set domain proteins, putative 0.0265 0.0431 1
Echinococcus granulosus tar DNA binding protein 0.0064 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0033 0.003 0.0367
Entamoeba histolytica cysteine protease, putative 0.002 0.0006 0.0346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0038 0.088
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0083 0.1031
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0038 0.0038 0.136
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.0168 0.0168
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.0375 0.4647
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0038 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0001 0.0023
Onchocerca volvulus 0.0098 0.0142 0.2501
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0038 0.088
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0068 0.2705
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0006 0.0346
Schistosoma mansoni cellular tumor antigen P53 0.0199 0.0317 0.0317
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.005 0.0059 0.3491
Onchocerca volvulus 0.0038 0.0038 0.0667
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0046 0.1071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0001 0.0023
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0161 0.025 0.025
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0061 0.0078 0.1346
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0199
Echinococcus granulosus tumor protein p63 0.1362 0.2328 0.2328
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.045 0.0749 0.2114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0224 0.3856
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0224 0.3856
Loa Loa (eye worm) hypothetical protein 0.0038 0.0038 0.0467
Treponema pallidum NADH oxidase 0.0061 0.0078 0.3124
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.004 0.0041 0.0709
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0064 0.1098
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0161 0.025 1
Onchocerca volvulus 0.0199 0.0317 0.5574
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0161 0.025 0.0703
Loa Loa (eye worm) hypothetical protein 0.0058 0.0072 0.0894
Schistosoma mansoni hypothetical protein 0.0018 0.0004 0.0004
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.0168 0.0168
Schistosoma mansoni hypothetical protein 0.004 0.004 0.004
Trichomonas vaginalis mercuric reductase, putative 0.0061 0.0078 0.1813
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0016 0.0578
Plasmodium vivax vivapain-2 0.0038 0.0038 0.136
Loa Loa (eye worm) hypothetical protein 0.0038 0.0038 0.0469
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0352 0.058 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0003 0.0003
Giardia lamblia GTOR 0.005 0.0059 0.7537
Echinococcus multilocularis tumor protein p63 0.1362 0.2328 0.2328
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0004 0.0004
Mycobacterium tuberculosis Conserved protein 0.0038 0.0038 0.0106
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0501
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0038 0.088
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0053 0.0064 0.018
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0006 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0083 0.0083
Onchocerca volvulus 0.0026 0.0016 0.0282
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0001 0.0001
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.005 0.0059 0.0059
Mycobacterium tuberculosis Conserved protein 0.0038 0.0038 0.0106
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.005 0.0059 0.1015
Leishmania major cathepsin L-like protease 0.0038 0.0038 0.0653
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0061 0.0078 0.022
Loa Loa (eye worm) beta-lactamase 0.0038 0.0038 0.0467
Onchocerca volvulus 0.0038 0.0038 0.0663
Trypanosoma cruzi major cysteine proteinase, putative 0.0114 0.017 0.2926
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0501
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0006 0.0346
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0404 0.0671 0.189
Trypanosoma cruzi trypanothione reductase, putative 0.0177 0.0278 0.4803
Toxoplasma gondii ABC1 family protein 0.0038 0.0038 0.1353
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0004 0.0044
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0004 0.0004
Schistosoma mansoni microtubule-associated protein tau 0.5798 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0037 0.0848
Toxoplasma gondii hypothetical protein 0.0055 0.0068 0.2428
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0027 0.0027
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0161 0.025 0.8974
Entamoeba histolytica cysteine proteinase 1, putative 0.002 0.0006 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0037 0.0848
Loa Loa (eye worm) hypothetical protein 0.0161 0.025 0.3097
Schistosoma mansoni smad 0.0018 0.0003 0.0003
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0038 0.0106
Plasmodium falciparum cysteine proteinase falcipain 3 0.0038 0.0038 0.136
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0038 0.0038
Mycobacterium tuberculosis Conserved hypothetical protein 0.0185 0.0292 0.0824
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0044
Brugia malayi MH2 domain containing protein 0.0267 0.0433 0.5366
Onchocerca volvulus 0.003 0.0024 0.0423
Trypanosoma cruzi cysteine protease, putative 0.002 0.0006 0.0101
Loa Loa (eye worm) phosphatidylinositol 3 0.005 0.0059 0.0729
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0006 0.0346
Brugia malayi TAR-binding protein 0.0064 0.0083 0.1031
Leishmania major cathepsin L-like protease 0.0146 0.0224 0.3856
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.0168 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0224 0.3856
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0038 0.0653
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0038 0.088
Onchocerca volvulus 0.0038 0.0038 0.0667
Brugia malayi Cathepsin L-like precursor 0.0038 0.0038 0.0469
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0038 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0038 0.065
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0001 0.0017
Leishmania major cathepsin L-like protease 0.0038 0.0038 0.0653
Onchocerca volvulus 0.0038 0.0038 0.0667
Schistosoma mansoni ferritin 0.0018 0.0003 0.0003
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.005 0.0059 0.1015
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0003 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0064 0.0179
Schistosoma mansoni ferritin 0.0018 0.0003 0.0003
Echinococcus multilocularis Smad4 0.0018 0.0003 0.0003
Echinococcus multilocularis smad 0.0018 0.0003 0.0003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0004 0.0044
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0004 0.0044
Entamoeba histolytica cysteine protease, putative 0.0038 0.0038 0.2247
Echinococcus granulosus cathepsin l cysteine peptidase 0.0038 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0038 0.088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0038 0.088
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.0193 0.0193
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0003 0.0003
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0142 0.1761
Echinococcus multilocularis thioredoxin glutathione reductase 0.0178 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0501
Mycobacterium tuberculosis Probable oxidoreductase 0.045 0.0749 0.2114
Leishmania major hypothetical protein, conserved 0.0026 0.0016 0.0278
Schistosoma mansoni smad1 5 8 and 0.0018 0.0003 0.0003
Entamoeba histolytica cysteine protease, putative 0.002 0.0006 0.0346
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0038 0.088
Entamoeba histolytica hypothetical protein 0.0114 0.0168 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0404 0.0671 0.1893
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.045 0.0749 0.2109
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0057 0.0988
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0072 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0059 0.1366
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0038 0.0038
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0038 0.0038
Schistosoma mansoni ferritin 0.0018 0.0003 0.0003
Echinococcus multilocularis lamin 0.003 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.003 0.0023 0.0286
Echinococcus multilocularis microtubule associated protein 2 0.5798 1 1
Leishmania major cysteine peptidase A (CPA) 0.0038 0.0038 0.0653
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0177 0.0278 0.0785
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0024 0.0298
Entamoeba histolytica cysteine protease, putative 0.002 0.0006 0.0346
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0161 0.025 0.8974
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0038 0.0875
Plasmodium falciparum acyl-CoA synthetase 0.004 0.004 0.1453
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0224 0.3856
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0016 0.0372
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0024 0.0298
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0064 0.1098
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0078 0.1346
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0038 0.0106
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.0064 0.378
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0006 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0038 0.088
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0061 0.0078 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0059 0.1366
Brugia malayi hypothetical protein 0.0017 0 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0019 0.0435
Echinococcus granulosus cathepsin L cysteine protease 0.002 0.0006 0.0006
Brugia malayi hypothetical protein 0.0345 0.0568 0.7042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0001 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0038 0.0875
Leishmania major hypothetical protein, conserved 0.0038 0.0038 0.065
Plasmodium vivax glutathione reductase, putative 0.0177 0.0278 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.003 0.003
Echinococcus granulosus cathepsin L 0.002 0.0006 0.0006
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0061 0.0078 0.022
Schistosoma mansoni ferritin light chain 0.0018 0.0003 0.0003
Leishmania major mitochondrial DNA polymerase beta 0.0352 0.058 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0161 0.025 0.0703
Onchocerca volvulus 0.0038 0.0038 0.0663
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0038 0.0667
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0006 0.0101
Schistosoma mansoni hypothetical protein 0.0018 0.0004 0.0004
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0053 0.0064 0.0179
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.045 0.0749 0.2114
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0038 0.0469
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0003 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0019 0.0435
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0001 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0038 0.0038
Brugia malayi beta-lactamase family protein 0.0038 0.0038 0.0467
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0404 0.0671 0.1893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0038 0.088
Entamoeba histolytica hypothetical protein 0.0114 0.0168 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.02
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0161 0.025 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0061 0.0078 0.0968
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0352 0.058 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0001 0.0017
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0006 0.0006
Brugia malayi Thioredoxin reductase 0.0177 0.0278 0.3452
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0038 0.0038
Brugia malayi Cathepsin L-like precursor 0.0038 0.0038 0.0469
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0038 0.0038
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0133 0.0202 0.3479
Mycobacterium ulcerans hypothetical protein 0.0038 0.0038 0.0106
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0105 0.0154 0.0434
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0038 0.1353
Plasmodium falciparum thioredoxin reductase 0.0177 0.0278 1
Echinococcus granulosus intermediate filament protein 0.003 0.0024 0.0024
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0006 0.0006
Echinococcus granulosus lamin 0.003 0.0024 0.0024
Loa Loa (eye worm) MH2 domain-containing protein 0.0267 0.0433 0.5366
Schistosoma mansoni lamin 0.003 0.0024 0.0024
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0001 0.0012
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.207 0.3552 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.002 0.0006 0.0209
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.005 0.0059 0.0059
Mycobacterium ulcerans transcriptional regulator 0.207 0.3552 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0016 0.0578
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0083 0.0083
Schistosoma mansoni apoferritin-2 0.0018 0.0003 0.0003
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0038 0.2247
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0078 0.1346
Schistosoma mansoni apoferritin-2 0.0018 0.0003 0.0003
Plasmodium vivax SET domain protein, putative 0.0033 0.003 0.1063
Mycobacterium leprae Probable lipase LipE 0.0038 0.0038 0.0106
Trichomonas vaginalis ferritin, putative 0.0018 0.0003 0.0069
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0038 0.0106
Trypanosoma cruzi trypanothione reductase, putative 0.0061 0.0078 0.1346
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0061 0.0078 0.3124
Loa Loa (eye worm) glutathione reductase 0.0177 0.0278 0.3452
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.026 0.4476
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0001 0.0001
Brugia malayi hypothetical protein 0.0026 0.0016 0.02
Schistosoma mansoni hypothetical protein 0.0018 0.0004 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0078 0.1346
Loa Loa (eye worm) hypothetical protein 0.0483 0.0807 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0061 0.0078 1
Plasmodium vivax unspecified product 0.002 0.0006 0.0209
Echinococcus granulosus GPCR family 2 0.0018 0.0004 0.0004
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0003 0.0008
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0006 0.0072
Schistosoma mansoni smad1 5 8 and 0.0018 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0019 0.0436
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.0224 0.3856
Mycobacterium ulcerans TetR family transcriptional regulator 0.207 0.3552 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0019 0.0436
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0038 0.065
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0057 0.0988
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0114 0.0168 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0038 0.088
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0061 0.0078 0.1346
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.0224 0.3856
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0038 0.0038 0.0467
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0105 0.0154 0.0435
Echinococcus multilocularis cysteine protease 0.0038 0.0038 0.0038
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0003 0.0003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0057 0.0988
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0057 0.0988
Loa Loa (eye worm) ctsf protein 0.0038 0.0038 0.0469
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0055 0.0068 0.2428
Echinococcus multilocularis GPCR, family 2 0.0018 0.0004 0.0004
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0068 0.2428
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0061 0.0078 0.1346
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0061 0.0078 0.1346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0019 0.0435
Trichomonas vaginalis glutathione reductase, putative 0.0061 0.0078 0.1813
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0224 0.3856
Trichomonas vaginalis esterase, putative 0.0038 0.0038 0.0875
Schistosoma mansoni hypothetical protein 0.0098 0.0142 0.0142
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.004 0.004 0.0114
Loa Loa (eye worm) hypothetical protein 0.0053 0.0064 0.0789
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0038 0.0106
Echinococcus multilocularis cysteine protease 0.0038 0.0038 0.0038
Schistosoma mansoni survival motor neuron protein 0.0098 0.0142 0.0142
Mycobacterium ulcerans hypothetical protein 0.0185 0.0292 0.0822
Trypanosoma cruzi cruzipain precursor, putative 0.0146 0.0224 0.3856
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.0224 0.3856
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0404 0.0671 0.1893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0038 0.088
Schistosoma mansoni peptidase Clp (S14 family) 0.0161 0.025 0.025
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0161 0.025 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0038 0.088
Echinococcus granulosus survival motor neuron protein 1 0.0483 0.0807 0.0807
Brugia malayi Cathepsin L-like precursor 0.0038 0.0038 0.0469
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0038 0.0106

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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