Detailed information for compound 667039

Basic information

Technical information
  • TDR Targets ID: 667039
  • Name: N-[4-(diethylsulfamoyl)phenyl]-3-pyrrolidin-1 -ylsulfonylbenzamide
  • MW: 465.586 | Formula: C21H27N3O5S2
  • H donors: 1 H acceptors: 5 LogP: 2.27 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(cc1)NC(=O)c1cccc(c1)S(=O)(=O)N1CCCC1)CC
  • InChi: 1S/C21H27N3O5S2/c1-3-23(4-2)30(26,27)19-12-10-18(11-13-19)22-21(25)17-8-7-9-20(16-17)31(28,29)24-14-5-6-15-24/h7-13,16H,3-6,14-15H2,1-2H3,(H,22,25)
  • InChiKey: QOFOIOLVLYSBBR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-(diethylsulfamoyl)phenyl]-3-pyrrolidin-1-ylsulfonyl-benzamide
  • N-[4-(diethylsulfamoyl)phenyl]-3-1-pyrrolidinylsulfonylbenzamide
  • ZINC01164554

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0653 0.0896
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0068 0.0073
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0357 0.0427
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0078 0.0094
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0428 0.0428
Mycobacterium leprae conserved hypothetical protein 0.011 0.1028 0.7529
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0218 0.1083
Brugia malayi Inositol-1 0.0045 0.0357 0.0427
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0096 0.0115
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0904 0.3114
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.0229 0.2255 0.2701
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0218 0.0218
Onchocerca volvulus 0.0026 0.0164 0.0729
Trypanosoma cruzi prolyl endopeptidase 0.0106 0.0989 0.5113
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0106 0.0989 0.1184
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0017 0.0072 0.0087
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0408 0.3903
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0011 0.0011 0.0011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0378 0.0453
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0218 0.0261
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0538 0.0644
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0428 0.0428
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0218 0.0261
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.1304 0.1304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0253 0.0842
Brugia malayi cytoplasmic intermediate filament protein 0.0012 0.0019 0.0022
Brugia malayi cathepsin L-like precursor 0.0035 0.0253 0.0303
Schistosoma mansoni hypothetical protein 0.0047 0.0378 0.0453
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0253 0.0842
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0013
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0042 0.0331 0.1672
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0064
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0171 0.0556
Echinococcus granulosus RUN 0.0019 0.0096 0.0115
Plasmodium vivax vivapain-2 0.0052 0.0428 0.4106
Echinococcus multilocularis prolyl endopeptidase 0.0106 0.0989 0.0989
Mycobacterium tuberculosis Probable thioesterase TesA 0.0017 0.0072 0.0078
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0106 0.0989 0.1184
Brugia malayi hypothetical protein 0.0234 0.2316 0.2774
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0653 0.0782
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1304 0.1562
Mycobacterium tuberculosis Conserved protein 0.011 0.1028 0.1423
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0003
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0218 0.0284
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0357 0.1206
Mycobacterium ulcerans polyketide synthase Pks13 0.003 0.0211 0.133
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1028 0.1231
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0078 0.0087
Echinococcus multilocularis CD36 class B scavenger receptor 0.0229 0.2255 0.2255
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.1141 0.1367
Entamoeba histolytica cysteine protease, putative 0.0052 0.0428 0.1455
Onchocerca volvulus 0.011 0.1028 0.4556
Loa Loa (eye worm) hypothetical protein 0.0151 0.145 0.1736
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0017
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0139 0.0786
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0428 0.2183
Echinococcus granulosus lysosome membrane protein 2 0.0229 0.2255 0.2701
Schistosoma mansoni hypothetical protein 0.0205 0.2008 0.2405
Onchocerca volvulus 0.011 0.1028 0.4556
Brugia malayi Cathepsin L-like precursor 0.0035 0.0253 0.0303
Brugia malayi Cathepsin L-like precursor 0.0052 0.0428 0.0513
Schistosoma mansoni hypothetical protein 0.0019 0.0096 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0171 0.0556
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0378 0.0453
Schistosoma mansoni hypothetical protein 0.0205 0.2008 0.2405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0253 0.0842
Loa Loa (eye worm) hypothetical protein 0.0035 0.0253 0.0303
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0139 0.0167
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0408 0.3903
Loa Loa (eye worm) hypothetical protein 0.0148 0.142 0.17
Loa Loa (eye worm) cysteine protease 0.0052 0.0428 0.0513
Brugia malayi Cathepsin L-like precursor 0.0052 0.0428 0.0513
Brugia malayi Cathepsin L-like precursor 0.0052 0.0428 0.0513
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0329 0.0394
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0093
Loa Loa (eye worm) hypothetical protein 0.0051 0.0426 0.051
Echinococcus granulosus lamin 0.0022 0.0124 0.0149
Echinococcus multilocularis GPCR, family 2 0.0047 0.0378 0.0378
Echinococcus granulosus transcription factor eb 0.0106 0.0989 0.1184
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0653 0.4687
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0171 0.0834
Echinococcus multilocularis cysteine protease 0.0052 0.0428 0.0428
Schistosoma mansoni lipoxygenase 0.0081 0.0731 0.0875
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0171 0.0556
Entamoeba histolytica cysteine proteinase 1, putative 0.0027 0.0171 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0357 0.2437
Brugia malayi Cathepsin L-like precursor 0.0017 0.0072 0.0087
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.016 0.0521
Brugia malayi Cathepsin L-like cysteine proteinase 0.0035 0.0253 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0218 0.0261
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0139 0.067
Toxoplasma gondii prolyl endopeptidase 0.0106 0.0989 0.9617
Loa Loa (eye worm) prolyl oligopeptidase 0.0011 0.0011 0.0013
Brugia malayi Muscleblind-like protein 0.0151 0.145 0.1736
Plasmodium falciparum cysteine proteinase falcipain 1 0.0027 0.0171 0.3821
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1028 0.3545
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0115
Leishmania major cathepsin L-like protease 0.0052 0.0428 0.2183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.2878 1
Plasmodium vivax unspecified product 0.0027 0.0171 0.1569
Brugia malayi prolyl oligopeptidase family protein 0.0011 0.0011 0.0013
Onchocerca volvulus 0.0035 0.0253 0.112
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Echinococcus multilocularis CD36 class B scavenger receptor 0.0229 0.2255 0.2255
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.039 0.0467
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.1028 0.1231
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0107 0.0128
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.1028 0.7529
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0428 0.0513
Trypanosoma cruzi cysteine peptidase, putative 0.0196 0.1923 1
Trypanosoma cruzi cruzipain precursor, putative 0.0017 0.0072 0.0321
Mycobacterium ulcerans lipase LipD 0.011 0.1028 0.7529
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Schistosoma mansoni cpg binding protein 0.006 0.0517 0.0619
Echinococcus granulosus Dipeptidyl peptidase 9 0.0011 0.0011 0.0013
Trypanosoma brucei oligopeptidase b 0.0042 0.0331 0.1672
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0012 0.0019 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0093
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0408 0.2075
Schistosoma mansoni hypothetical protein 0.004 0.0313 0.0375
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0329 0.0394
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.0428 1
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0171 0.0834
Schistosoma mansoni lamin 0.0022 0.0124 0.0149
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.002 0.0107 0.0541
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0218 0.1083
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0087
Echinococcus granulosus microtubule associated protein 2 0.0684 0.6957 0.8332
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0357 0.1808
Loa Loa (eye worm) hypothetical protein 0.011 0.1028 0.1231
Onchocerca volvulus 0.0042 0.0334 0.148
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0171 0.0204
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.1008 0.9811
Onchocerca volvulus 0.0052 0.0428 0.19
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0008
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0096 0.0836
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0126 0.0126
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0078 0.0094
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1028 0.3545
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0538 0.0644
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0042 0.0042
Echinococcus granulosus cysteine protease 0.0027 0.0171 0.0204
Brugia malayi RNA binding protein 0.0062 0.0538 0.0644
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1028 0.5317
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0016 0.0066 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0017 0.0069 0.0074
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0357 0.1206
Echinococcus multilocularis CD36 class B scavenger receptor 0.0229 0.2255 0.2255
Toxoplasma gondii type I fatty acid synthase, putative 0.0015 0.0046 0.0346
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0408 0.2075
Onchocerca volvulus 0.0019 0.0096 0.0426
Echinococcus multilocularis transcription factor eb 0.0106 0.0989 0.0989
Echinococcus multilocularis expressed conserved protein 0.0092 0.0843 0.0843
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0357 0.1808
Loa Loa (eye worm) prolyl oligopeptidase 0.0011 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0049 0.0401 0.048
Entamoeba histolytica hypothetical protein 0.0036 0.0271 0.0905
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0218 0.1083
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0015 0.0048 0.0044
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1336 0.16
Brugia malayi CHE-14 protein 0.0042 0.0329 0.0394
Onchocerca volvulus 0.0057 0.0483 0.2144
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0022 0.0124 0.0149
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0171 0.0204
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0096 0.0096
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0139 0.0786
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0096 0.0096
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.1304 0.1562
Mycobacterium tuberculosis Polyketide synthase Pks13 0.003 0.0211 0.0274
Mycobacterium ulcerans Type I modular polyketide synthase 0.002 0.0107 0.0541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Onchocerca volvulus 0.0052 0.0428 0.19
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.0229 0.2255 1
Brugia malayi TAR-binding protein 0.0062 0.0538 0.0644
Loa Loa (eye worm) hypothetical protein 0.0819 0.835 1
Brugia malayi Cathepsin L-like precursor 0.0052 0.0428 0.0513
Loa Loa (eye worm) hypothetical protein 0.005 0.0408 0.0488
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Echinococcus granulosus CD36 class B scavenger receptor 0.0229 0.2255 0.2701
Echinococcus granulosus CD36 class B scavenger receptor 0.0229 0.2255 0.2701
Plasmodium vivax vivapain-2 0.0052 0.0428 0.4106
Echinococcus multilocularis microtubule associated protein 2 0.0684 0.6957 0.6957
Mycobacterium leprae Polyketide synthase Pks13 0.003 0.0211 0.133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0378 0.0453
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0016 0.0066 0.0229
Mycobacterium ulcerans polyketide synthase 0.0022 0.012 0.064
Leishmania major hypothetical protein, conserved 0.011 0.1028 0.5317
Onchocerca volvulus 0.0024 0.0139 0.0617
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0171 0.0204
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0357 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0171 0.0204
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Brugia malayi isocitrate dehydrogenase 0.0031 0.0218 0.0261
Loa Loa (eye worm) RNA binding protein 0.0062 0.0538 0.0644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.1304 0.1562
Trypanosoma cruzi cysteine protease, putative 0.0027 0.0171 0.0834
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0271 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0538 0.0538
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0653 0.0782
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0428 0.0513
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0022 0.0124 0.0149
Onchocerca volvulus 0.0052 0.0428 0.19
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0938 0.1123
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0042 0.0051
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.002 0.01 0.0119
Mycobacterium ulcerans Type I modular polyketide synthase 0.002 0.0107 0.0541
Echinococcus multilocularis RUN 0.0019 0.0096 0.0096
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1304 0.1562
Leishmania major cathepsin L-like protease 0.0052 0.0428 0.2183
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0218 0.2036
Schistosoma mansoni hypothetical protein 0.081 0.8254 0.9886
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0042 0.0331 0.0443
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0378 0.0378
Brugia malayi Doublecortin family protein 0.0019 0.0096 0.0115
Schistosoma mansoni lipoxygenase 0.0116 0.109 0.1305
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0139 0.0786
Onchocerca volvulus 0.0049 0.0401 0.1779
Trichomonas vaginalis esterase, putative 0.011 0.1028 0.3545
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0013 0.0033 0.0215
Trypanosoma cruzi oligopeptidase b 0.0042 0.0331 0.1672
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0653 0.6317
Echinococcus multilocularis geminin 0.0205 0.2008 0.2008
Leishmania major cathepsin L-like protease 0.0196 0.1923 1
Mycobacterium tuberculosis Probable hydrolase 0.011 0.1028 0.1423
Trichomonas vaginalis helicase, putative 0.0013 0.003 0.0064
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0139 0.0786
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0093
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0106 0.0989 0.5113
Trypanosoma cruzi cysteine peptidase, putative 0.0196 0.1923 1
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0171 0.0834
Brugia malayi intermediate filament protein 0.0022 0.0124 0.0149
Loa Loa (eye worm) hypothetical protein 0.011 0.1028 0.1231
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0076 0.0091
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0218 0.1083
Echinococcus granulosus cathepsin l1 0.0052 0.0428 0.0513
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0139 0.0173
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0139 0.0173
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0171 0.0204
Onchocerca volvulus 0.0022 0.0124 0.0552
Loa Loa (eye worm) fatty acid synthase 0.002 0.0104 0.0125
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0904 0.1083
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0428 0.1455
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0428 0.0428
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0042 0.0042
Loa Loa (eye worm) inositol-1 0.0045 0.0357 0.0427
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0538 0.0644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1304 0.1562
Leishmania major oligopeptidase b 0.0042 0.0331 0.1672
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0164 0.0197
Schistosoma mansoni hypothetical protein 0.0101 0.0938 0.1123
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0787 0.0943
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Echinococcus multilocularis cathepsin L 0.0027 0.0171 0.0171
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1028 0.3545
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Echinococcus multilocularis cysteine protease 0.0052 0.0428 0.0428
Entamoeba histolytica hypothetical protein 0.0036 0.0271 0.0905
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0253 0.0303
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0011 0.0011 0.0011
Toxoplasma gondii type I fatty acid synthase, putative 0.0023 0.013 0.1168
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0538 0.0644
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0904 0.1083
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.1304 0.1562
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.002 0.0107 0.0128
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0011 0.0007 0.0008
Echinococcus multilocularis musashi 0.0022 0.0124 0.0124
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0042 0.0331 0.1672
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0309 0.0412
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0218 0.0218
Echinococcus granulosus expressed conserved protein 0.0092 0.0843 0.1009
Loa Loa (eye worm) hypothetical protein 0.0086 0.0787 0.0943
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0072 0.0321
Echinococcus granulosus GPCR family 2 0.0047 0.0378 0.0453
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0064
Brugia malayi hypothetical protein 0.0032 0.0227 0.0271
Echinococcus granulosus cpg binding protein 0.006 0.0517 0.0619
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0087
Brugia malayi hypothetical protein 0.0019 0.0096 0.0115
Echinococcus multilocularis CD36 class B scavenger receptor 0.0229 0.2255 0.2255
Brugia malayi CXXC zinc finger family protein 0.0057 0.0483 0.0579
Onchocerca volvulus Prolyl endopeptidase homolog 0.0106 0.0989 0.4384
Schistosoma mansoni cathepsin s 0.0017 0.0072 0.0087
Plasmodium vivax hypothetical protein, conserved 0.011 0.1028 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0253 0.0303
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0653 0.3358
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.002 0.0107 0.0541
Loa Loa (eye worm) hypothetical protein 0.011 0.1028 0.1231
Loa Loa (eye worm) ctsf protein 0.0052 0.0428 0.0513
Loa Loa (eye worm) beta-lactamase 0.011 0.1028 0.1231
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0139 0.0447
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0011 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0428 0.1455
Mycobacterium ulcerans thioesterase TesA 0.0017 0.0072 0.0275
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0538 0.0644
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.109 0.109
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0022 0.012 0.064
Loa Loa (eye worm) hypothetical protein 0.011 0.1028 0.1231
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Brugia malayi prolyl oligopeptidase family protein 0.0011 0.0011 0.0013
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0653 0.4687
Schistosoma mansoni hypothetical protein 0.0047 0.0378 0.0453
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1028 0.1231
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.0428 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0072 0.0087
Echinococcus multilocularis lamin 0.0022 0.0124 0.0124
Schistosoma mansoni inositol monophosphatase 0.0045 0.0357 0.0427
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0139 0.0786
Brugia malayi hypothetical protein 0.005 0.0408 0.0488
Loa Loa (eye worm) hypothetical protein 0.011 0.1028 0.1231
Loa Loa (eye worm) intermediate filament protein 0.0022 0.0124 0.0149
Echinococcus multilocularis CD36 class B scavenger receptor 0.0229 0.2255 0.2255
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0357 0.1206
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.1353 1
Echinococcus granulosus acylamino acid releasing enzyme 0.0011 0.0011 0.0013
Mycobacterium ulcerans polyketide synthase 0.002 0.0107 0.0541
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.0164 0.0197
Schistosoma mansoni intermediate filament proteins 0.0022 0.0124 0.0149
Echinococcus multilocularis muscleblind protein 0.0151 0.145 0.145
Echinococcus granulosus cathepsin L 0.0027 0.0171 0.0204
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0819 0.835 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Schistosoma mansoni hypothetical protein 0.004 0.0313 0.0375
Plasmodium vivax unspecified product 0.0017 0.0072 0.0603
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0171 0.0556
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.0428 0.0513
Brugia malayi prolyl oligopeptidase family protein 0.0011 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0035 0.026 0.0311
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0011 0.0013 0.0016
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1028 0.3545
Echinococcus multilocularis tumor protein p63 0.0334 0.3344 0.3344
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0022 0.012 0.064
Schistosoma mansoni loxhd1 0.0019 0.0096 0.0115
Echinococcus granulosus intermediate filament protein 0.0022 0.0124 0.0149
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1028 0.3545
Trypanosoma cruzi cysteine peptidase, putative 0.0196 0.1923 1
Leishmania major cathepsin L-like protease 0.0196 0.1923 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0171 0.0556
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.002 0.0107 0.0128
Brugia malayi prolyl oligopeptidase family protein 0.0106 0.0989 0.1184
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0093
Echinococcus multilocularis lamin dm0 0.0022 0.0124 0.0124
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0022 0.012 0.0146
Schistosoma mansoni hypothetical protein 0.0036 0.0271 0.0324
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0105 0.0983 0.1178
Trypanosoma cruzi oligopeptidase b 0.0042 0.0331 0.1672
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0218 0.1083
Schistosoma mansoni hypothetical protein 0.0048 0.039 0.0467
Onchocerca volvulus 0.0022 0.0124 0.0552
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0106 0.0989 0.1184
Loa Loa (eye worm) hypothetical protein 0.0151 0.145 0.1736
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.2878 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.0157 0.1511 0.181
Leishmania major hypothetical protein, conserved 0.005 0.0408 0.2075
Loa Loa (eye worm) hypothetical protein 0.0042 0.0329 0.0394
Loa Loa (eye worm) STAT protein 0.0157 0.1511 0.181
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0357 0.0357
Schistosoma mansoni microtubule-associated protein tau 0.0684 0.6957 0.8332
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.142 0.17
Mycobacterium ulcerans hypothetical protein 0.011 0.1028 0.7529
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0904 0.0904
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0171 0.0834
Mycobacterium leprae Probable lipase LipE 0.011 0.1028 0.7529
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0408 0.9506
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.1028 0.1231
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0653 0.0653
Trypanosoma brucei prolyl oligopeptidase, putative 0.0042 0.0331 0.1672
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0378 0.0453
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.142 0.17
Echinococcus multilocularis lysosome membrane protein 2 0.0229 0.2255 0.2255
Leishmania major cathepsin L-like protease 0.0052 0.0428 0.2183
Brugia malayi Cathepsin L-like precursor 0.0052 0.0428 0.0513
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0011 0.0011 0.0049
Schistosoma mansoni cd36 antigen 0.0086 0.0787 0.0943
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0096 0.2036
Echinococcus granulosus prolyl endopeptidase 0.0106 0.0989 0.1184
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0408 0.9506
Brugia malayi hypothetical protein 0.0086 0.0787 0.0943
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.1028 0.1423
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0068 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0064
Loa Loa (eye worm) hypothetical protein 0.0101 0.0938 0.1123
Echinococcus multilocularis muscleblind protein 1 0.0151 0.145 0.145
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.1028 0.1423
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0378 0.0453
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.1028 0.7529
Onchocerca volvulus 0.0048 0.039 0.173
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Mycobacterium tuberculosis Polyketide synthase Pks2 0.002 0.01 0.0119
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0167
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0538 0.0644
Brugia malayi Intermediate filament tail domain containing protein 0.0022 0.0124 0.0149
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.002 0.0107 0.0541
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Echinococcus multilocularis acylamino acid releasing enzyme 0.0011 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1028 0.5317
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.003 0.0064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0064
Echinococcus granulosus lamin dm0 0.0022 0.0124 0.0149
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0022 0.012 0.064
Loa Loa (eye worm) hypothetical protein 0.0035 0.0253 0.0303
Leishmania major cathepsin L-like protease 0.0196 0.1923 1
Loa Loa (eye worm) hypothetical protein 0.0234 0.2316 0.2774
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0428 0.0513
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0428 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0026 0.0164 0.0208
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0078 0.1599
Plasmodium vivax vivapain-1 0.0027 0.0171 0.1569
Leishmania major cathepsin L-like protease 0.0052 0.0428 0.2183
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2316 0.2316
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0078 0.032
Echinococcus granulosus geminin 0.0205 0.2008 0.2405
Schistosoma mansoni patched 1 0.0042 0.0329 0.0394
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0171 0.0834
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0218 0.2036
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.1353 1
Echinococcus granulosus tar DNA binding protein 0.0062 0.0538 0.0644
Loa Loa (eye worm) hypothetical protein 0.0106 0.0989 0.1184
Schistosoma mansoni hypothetical protein 0.004 0.0313 0.0375
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0653 0.4687
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0167
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0357 0.1808
Mycobacterium ulcerans beta-lactamase 0.011 0.1028 0.7529
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0016 0.0066 0.0229
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0428 0.1455
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0078 0.0078
Echinococcus multilocularis dnaJ subfamily B 0.081 0.8254 0.8254
Loa Loa (eye worm) hypothetical protein 0.0052 0.0428 0.0513
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0819 0.835 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0139 0.0786
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.1028 0.1231
Trypanosoma cruzi cruzipain precursor, putative 0.0196 0.1923 1
Brugia malayi beta-lactamase family protein 0.011 0.1028 0.1231
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0378 0.0453
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0329 0.1108
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.003 0.0211 0.0274
Mycobacterium ulcerans thioesterase 0.0017 0.0072 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0011 0.0011 0.0013
Plasmodium vivax vivapain-3 0.0027 0.0171 0.1569
Schistosoma mansoni CD36-like class B scavenger receptor 0.0229 0.2255 0.2701
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0139 0.0786
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0218 0.0261
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0027 0.0171 0.0834
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.1028 0.1423
Onchocerca volvulus 0.0052 0.0428 0.19
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0068 0.0073
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.092 0.1101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0271 0.0324
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0139 0.067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0329 0.0329
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.1304 0.1304
Toxoplasma gondii cathepsin CPL 0.0052 0.0428 0.4106
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0022 0.012 0.0146
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0401 0.048
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0093
Mycobacterium tuberculosis Probable peptidase 0.0042 0.0331 0.0443
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0042 0.0051
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0357 0.1808
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0126 0.0151
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.002 0.0107 0.0128
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.0428 0.0513
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.0428 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0538 0.0644
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0068 0.0073
Mycobacterium ulcerans Type I modular polyketide synthase 0.002 0.0107 0.0541
Schistosoma mansoni rab6-interacting 0.0019 0.0096 0.0115
Schistosoma mansoni polycystin 1-related 0.0019 0.0096 0.0115
Schistosoma mansoni hypothetical protein 0.0022 0.0126 0.0151
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0096 0.0115
Onchocerca volvulus Cathepsin F homolog 0.0052 0.0428 0.19
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0428 0.1455
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0271 0.0324
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0329 0.0394
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0357 0.1206
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0078 0.0656
Entamoeba histolytica hypothetical protein 0.0036 0.0271 0.0905
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0039 0.0295 0.0354
Loa Loa (eye worm) hypothetical protein 0.0229 0.2255 0.2701
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0218 0.0218
Schistosoma mansoni hypothetical protein 0.0047 0.0378 0.0453
Schistosoma mansoni rab6-interacting 0.0019 0.0096 0.0115
Loa Loa (eye worm) hypothetical protein 0.0229 0.2255 0.2701
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0483 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0139 0.0786
Mycobacterium ulcerans hypothetical protein 0.0024 0.0139 0.0786
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.1028 0.1423
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.1353 0.1882
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1336 0.1336
Mycobacterium tuberculosis Conserved protein 0.011 0.1028 0.1423
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Echinococcus granulosus cathepsin l1 0.0035 0.0253 0.0303
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0017 0.0072 0.0275
Loa Loa (eye worm) hypothetical protein 0.0017 0.0072 0.0087
Loa Loa (eye worm) hypothetical protein 0.0022 0.012 0.0144
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0309 0.2071
Brugia malayi hypothetical protein 0.0036 0.0271 0.0324
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.0064
Schistosoma mansoni CD36-like class B scavenger receptor 0.0229 0.2255 0.2701
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0042 0.0331 0.1672
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0011 0.0011 0.0013
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0819 0.835 0.835
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.003 0.0064
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0179 0.1747 0.908
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0218 0.496
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0139 0.0167
Brugia malayi Cathepsin L-like precursor 0.0052 0.0428 0.0513
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0095 0.0874 0.1207
Echinococcus multilocularis protein patched 0.0042 0.0329 0.0329
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0428 0.0428
Echinococcus granulosus tumor protein p63 0.0334 0.3344 0.4005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0218 0.2036
Onchocerca volvulus 0.0052 0.0428 0.19
Mycobacterium leprae Probable polyketide synthase Pks1 0.0022 0.012 0.064
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0218 0.0218
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0011 0.0011 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Echinococcus granulosus CD36 class B scavenger receptor 0.0229 0.2255 0.2701
Echinococcus granulosus cathepsin L cysteine protease 0.0027 0.0171 0.0204
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.2878 1
Schistosoma mansoni lamin 0.0022 0.0124 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0139 0.0167
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.1028 0.1423
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.0357 0.0427
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0042 0.0331 0.2241
Schistosoma mansoni hypothetical protein 0.0047 0.0378 0.0453
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0428 0.19
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0042 0.0051
Onchocerca volvulus 0.0019 0.0096 0.0426
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.109 0.1305
Onchocerca volvulus 0.011 0.1028 0.4556
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.1028 0.1028
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0022 0.012 0.0146
Loa Loa (eye worm) hypothetical protein 0.0098 0.0904 0.1083
Trypanosoma brucei prolyl endopeptidase 0.0106 0.0989 0.5113
Loa Loa (eye worm) fibroinase 0.0052 0.0428 0.0513
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0042 0.0331 0.1672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0171 0.0556
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0408 0.2075
Brugia malayi beta-lactamase 0.011 0.1028 0.1231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0538 0.0644
Loa Loa (eye worm) hypothetical protein 0.0229 0.2255 0.2701
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.1923 1
Echinococcus granulosus muscleblind protein 0.0151 0.145 0.1736
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0078 0.5
Loa Loa (eye worm) hypothetical protein 0.0105 0.0983 0.1178
Entamoeba histolytica cysteine protease, putative 0.0027 0.0171 0.0556
Brugia malayi prolyl oligopeptidase family protein 0.0011 0.0011 0.0013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.1304 0.1562
Mycobacterium tuberculosis Possible penicillin-binding protein 0.07 0.7122 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2878 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.142 0.17
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.1028 0.1423
Echinococcus granulosus CD36 class B scavenger receptor 0.0229 0.2255 0.2701
Loa Loa (eye worm) hypothetical protein 0.011 0.1028 0.1231
Entamoeba histolytica hypothetical protein 0.0036 0.0271 0.0905
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0357 0.3401
Toxoplasma gondii ABC1 family protein 0.011 0.1028 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0096 0.0115
Echinococcus granulosus CD36 class B scavenger receptor 0.0229 0.2255 0.2701
Echinococcus multilocularis cpg binding protein 0.006 0.0517 0.0517
Onchocerca volvulus 0.0052 0.0428 0.19
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.0428 0.0513
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0139 0.0786
Loa Loa (eye worm) hypothetical protein 0.0086 0.0787 0.0943
Onchocerca volvulus 0.0052 0.0428 0.19
Brugia malayi CD36 family protein 0.0229 0.2255 0.2701
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0042 0.0331 0.2241
Brugia malayi hypothetical protein 0.0019 0.0096 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.0064
Brugia malayi Cathepsin L-like precursor 0.0035 0.0253 0.0303
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0115
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.0819 0.835 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0167
Trypanosoma cruzi major cysteine proteinase, putative 0.0154 0.1489 0.7731
Brugia malayi hypothetical protein 0.0086 0.0787 0.0943
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0003
Onchocerca volvulus Fatty acid synthase homolog 0.0037 0.0276 0.1222
Brugia malayi beta-lactamase family protein 0.011 0.1028 0.1231
Schistosoma mansoni hypothetical protein 0.004 0.0313 0.0375
Leishmania major cysteine peptidase A (CPA) 0.0052 0.0428 0.2183
Schistosoma mansoni survival motor neuron protein 0.0048 0.039 0.0467
Mycobacterium tuberculosis Conserved protein 0.011 0.1028 0.1423
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0428 0.19
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0072 0.0087
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0139 0.067
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.2878 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0428 0.1455
Leishmania major cathepsin L-like protease 0.0052 0.0428 0.2183
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0139 0.0447
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0653 0.0782
Entamoeba histolytica cysteine proteinase 2 0.0027 0.0171 0.0556
Trypanosoma brucei hypothetical protein, conserved 0.011 0.1028 0.5317
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0096 0.0115
Schistosoma mansoni cpg binding protein 0.006 0.0517 0.0619
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2316 0.2774
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0011 0.0011 0.0013
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0011 0.0011 0.0013
Echinococcus multilocularis protein dispatched 1 0.0048 0.039 0.039
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0022 0.012 0.064
Echinococcus granulosus dnaJ subfamily B 0.081 0.8254 0.9886
Schistosoma mansoni cpg binding protein 0.0057 0.0483 0.0579
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0428 0.1455
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0096 0.0096

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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