Detailed information for compound 67213

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 524.721 | Formula: C26H28N4O2S3
  • H donors: 0 H acceptors: 4 LogP: 5.71 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(CSc1nnc(n1c1ccccc1)[C@@H]1C[C@H](CN1S(=O)(=O)c1ccc2c(c1)cccc2)S)C
  • InChi: 1S/C26H28N4O2S3/c1-18(2)17-34-26-28-27-25(30(26)21-10-4-3-5-11-21)24-15-22(33)16-29(24)35(31,32)23-13-12-19-8-6-7-9-20(19)14-23/h3-14,18,22,24,33H,15-17H2,1-2H3/t22-,24+/m1/s1
  • InChiKey: ZOQPMFIWZLMKHE-VWNXMTODSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens endothelin converting enzyme 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Toxoplasma gondii peptidase family M13 protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma mansoni family M13 unassigned peptidase (M13 family) Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Echinococcus multilocularis endothelin converting enzyme 1 Get druggable targets OG5_127344 All targets in OG5_127344
Echinococcus granulosus endothelin converting enzyme 1 Get druggable targets OG5_127344 All targets in OG5_127344
Neospora caninum hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium leprae probable zinc metalloprotease Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma japonicum ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative Get druggable targets OG5_127344 All targets in OG5_127344
Brugia malayi Peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium ulcerans zinc metalloprotease Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma japonicum IPR000718,Peptidase M13, neprilysin,domain-containing Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Onchocerca volvulus Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae cell division protein FtsZ 0.0055 0.0267 0.2777
Echinococcus granulosus Tubulin beta 2C chain 0.0235 0.19 0.4377
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0055 0.0267 1
Plasmodium vivax delta tubulin, putative 0.0055 0.0267 0.1323
Leishmania major beta tubulin 0.0235 0.19 0.1821
Trypanosoma brucei beta tubulin 0.0127 0.0921 0.0833
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0114 0.0802 0.0802
Echinococcus multilocularis tubulin alpha 1C chain 0.0178 0.1379 0.3179
Leishmania major beta tubulin 0.0235 0.19 0.1821
Echinococcus granulosus tubulin subunit TubB 0.0178 0.1379 0.3179
Echinococcus multilocularis tubulin alpha chain 0.0178 0.1379 0.3179
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0058 0.0288 0.0396
Echinococcus granulosus tubulin alpha chain 0.0178 0.1379 0.3179
Leishmania major alpha tubulin 0.0178 0.1379 0.1296
Leishmania major beta tubulin 0.0235 0.19 0.1821
Mycobacterium leprae probable zinc metalloprotease 0.0114 0.0802 1
Trypanosoma brucei beta tubulin 0.0235 0.19 0.1821
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0114 0.0802 1
Trypanosoma cruzi tubulin gamma chain 0.0127 0.0921 0.0833
Echinococcus multilocularis endothelin converting enzyme 1 0.0114 0.0802 0.1847
Brugia malayi Cytochrome P450 family protein 0.0029 0.0031 0.0031
Trichomonas vaginalis tubulin beta chain, putative 0.0178 0.1379 0.7116
Leishmania major beta tubulin 0.0235 0.19 0.1821
Brugia malayi Tubulin alpha chain 0.0055 0.0267 0.0267
Trypanosoma brucei tubulin gamma chain 0.0127 0.0921 0.0833
Trichomonas vaginalis tubulin beta chain, putative 0.0178 0.1379 0.7116
Echinococcus multilocularis tubulin alpha 3 chain 0.0178 0.1379 0.3179
Loa Loa (eye worm) hypothetical protein 0.0056 0.0278 0.0278
Mycobacterium ulcerans cell division protein FtsZ 0.0055 0.0267 0.2422
Trypanosoma brucei alpha tubulin 0.0178 0.1379 0.1296
Trichomonas vaginalis tubulin beta chain, putative 0.0178 0.1379 0.7116
Loa Loa (eye worm) hypothetical protein 0.0178 0.1379 0.1379
Leishmania major C-8 sterol isomerase-like protein 0.1126 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0549 0.0549
Loa Loa (eye worm) mbt repeat family protein 0.0265 0.2174 0.2174
Trypanosoma cruzi zeta tubulin, putative 0.0055 0.0267 0.0173
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0122 0.0877 0.0877
Trypanosoma brucei alpha tubulin, putative 0.0072 0.0419 0.0326
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0058 0.0288 0.0396
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0114 0.0802 0.1103
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0096 0.0267
Schistosoma mansoni sex comb on midleg homolog 0.0255 0.208 0.286
Leishmania major beta tubulin 0.0235 0.19 0.1821
Schistosoma mansoni tubulin subunit beta 0.0235 0.19 0.2613
Mycobacterium ulcerans zinc metalloprotease 0.0114 0.0802 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0438 0.3747 1
Loa Loa (eye worm) tubulin alpha chain 0.0178 0.1379 0.1379
Giardia lamblia Gamma tubulin 0.0127 0.0921 0.417
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.0314 0.2616 0.6027
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0222 0.0127
Brugia malayi Tubulin beta chain 0.0072 0.0419 0.0419
Onchocerca volvulus 0.0289 0.2393 0.6097
Echinococcus granulosus beta tubulin 0.0235 0.19 0.4377
Trichomonas vaginalis tubulin, putative 0.0055 0.0267 0.0948
Echinococcus multilocularis tubulin subunit TubB 0.0178 0.1379 0.3179
Plasmodium falciparum tubulin gamma chain 0.0127 0.0921 0.4801
Schistosoma mansoni tubulin subunit gamma 0.0127 0.0921 0.1267
Plasmodium falciparum alpha tubulin 1 0.0178 0.1379 0.7235
Echinococcus multilocularis polycomb protein SCMH1 0.0255 0.208 0.4792
Brugia malayi jmjC domain containing protein 0.0131 0.0958 0.0958
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0222 0.0222
Schistosoma mansoni tubulin subunit beta 0.0235 0.19 0.2613
Trypanosoma brucei epsilon tubulin 0.0127 0.0921 0.0833
Schistosoma mansoni tubulin subunit alpha 0.0178 0.1379 0.1897
Leishmania major alpha tubulin 0.0178 0.1379 0.1296
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0222 0.0127
Onchocerca volvulus 0.0072 0.0419 0.0406
Loa Loa (eye worm) BEN-1 protein 0.0235 0.19 0.19
Echinococcus granulosus Tubulin alpha 1 chain 0.0178 0.1379 0.3179
Echinococcus granulosus tubulin delta chain 0.0055 0.0267 0.0615
Trichomonas vaginalis tubulin alpha chain, putative 0.0072 0.0419 0.1792
Echinococcus granulosus tubulin gamma 1 chain 0.0127 0.0921 0.2123
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0072 0.0419 0.1792
Schistosoma mansoni endothelin-converting enzyme-related 0.0028 0.0017 0.0024
Schistosoma mansoni inositol monophosphatase 0.0036 0.0096 0.0132
Trichomonas vaginalis tubulin gamma chain, putative 0.0055 0.0267 0.0948
Trypanosoma cruzi tubulin delta chain 0.0055 0.0267 0.0173
Leishmania major alpha tubulin 0.0178 0.1379 0.1296
Schistosoma mansoni tubulin subunit epsilon 0.0127 0.0921 0.1267
Schistosoma mansoni hypothetical protein 0.003 0.0035 0.0048
Schistosoma mansoni tubulin subunit alpha 0.0178 0.1379 0.1897
Echinococcus multilocularis tubulin alpha 3 chain 0.0178 0.1379 0.3179
Leishmania major alpha tubulin 0.0178 0.1379 0.1296
Leishmania major beta tubulin 0.0235 0.19 0.1821
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.0017 0.0024
Echinococcus granulosus Tubulin beta 2C chain 0.0235 0.19 0.4377
Toxoplasma gondii PLU-1 family protein 0.0042 0.0147 0.0544
Schistosoma mansoni jumonji/arid domain-containing protein 0.0089 0.0575 0.0791
Echinococcus multilocularis Tubulin beta 2C chain 0.0235 0.19 0.4377
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.0017 0.0024
Schistosoma mansoni hypothetical protein 0.003 0.0035 0.0048
Brugia malayi follicle stimulating hormone receptor 0.0231 0.1864 0.1864
Echinococcus granulosus beta tubulin 0.0235 0.19 0.4377
Leishmania major alpha tubulin 0.0178 0.1379 0.1296
Echinococcus granulosus histone acetyltransferase MYST2 0.0092 0.0599 0.1381
Leishmania major delta tubulin, putative 0.0055 0.0267 0.0173
Treponema pallidum cell division protein FtsZ 0.0055 0.0267 0.5
Entamoeba histolytica tubulin family protein 0.0235 0.19 1
Leishmania major alpha tubulin 0.0178 0.1379 0.1296
Brugia malayi tubulin alpha chain - mouse 0.0178 0.1379 0.1379
Trypanosoma cruzi epsilon tubulin, putative 0.0127 0.0921 0.0833
Brugia malayi Tubulin alpha chain 0.0178 0.1379 0.1379
Echinococcus granulosus tubulin alpha 1C chain 0.0178 0.1379 0.3179
Trypanosoma brucei tubulin delta chain 0.0055 0.0267 0.0173
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.003 0.0035 0.0048
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0369 0.3117 0.4288
Schistosoma mansoni tubulin subunit alpha 0.0178 0.1379 0.1897
Trypanosoma cruzi epsilon tubulin, putative 0.0127 0.0921 0.0833
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0222 0.0511
Loa Loa (eye worm) hypothetical protein 0.0086 0.0549 0.0549
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0222 0.0511
Echinococcus granulosus Tubulin beta 2C chain 0.0235 0.19 0.4377
Loa Loa (eye worm) alpha-tubulin 0.0178 0.1379 0.1379
Trypanosoma cruzi beta tubulin, putative 0.0235 0.19 0.1821
Leishmania major beta tubulin 0.0235 0.19 0.1821
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0055 0.0267 0.0948
Echinococcus multilocularis SAM and MBT domain containing protein 0.0369 0.3117 0.7183
Trypanosoma brucei zeta tubulin 0.0055 0.0267 0.0173
Loa Loa (eye worm) beta-tubulin 0.0235 0.19 0.19
Echinococcus granulosus polycomb protein SCMH1 0.0255 0.208 0.4792
Trichomonas vaginalis tubulin beta chain, putative 0.0178 0.1379 0.7116
Echinococcus granulosus SAM and MBT domain containing protein 0.0369 0.3117 0.7183
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0055 0.0267 0.1189
Trypanosoma brucei alpha tubulin 0.0178 0.1379 0.1296
Trypanosoma brucei alpha tubulin 0.0178 0.1379 0.1296
Giardia lamblia Beta tubulin 0.0235 0.19 1
Schistosoma mansoni alpha tubulin 0.0178 0.1379 0.1897
Loa Loa (eye worm) zinc metallopeptidase 4 0.0028 0.0017 0.0017
Trichomonas vaginalis tubulin alpha chain, putative 0.0072 0.0419 0.1792
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0222 0.0697
Echinococcus granulosus tubulin alpha chain 0.0178 0.1379 0.3179
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0096 0.0221
Echinococcus granulosus Tubulin alpha 1 chain 0.0178 0.1379 0.3179
Trichomonas vaginalis tubulin epsilon chain, putative 0.0235 0.19 1
Echinococcus multilocularis tubulin alpha chain 0.0178 0.1379 0.3179
Schistosoma mansoni tubulin subunit beta 0.0055 0.0267 0.0367
Trypanosoma brucei alpha tubulin 0.0178 0.1379 0.1296
Echinococcus granulosus peroxisome assembly protein 26 0.0178 0.1379 0.3179
Trypanosoma cruzi alpha tubulin, putative 0.0178 0.1379 0.1296
Echinococcus multilocularis Tubulin alpha 1 chain 0.0178 0.1379 0.3179
Loa Loa (eye worm) hypothetical protein 0.0106 0.0725 0.0725
Giardia lamblia Alpha-tubulin 0.0178 0.1379 0.69
Loa Loa (eye worm) hypothetical protein 0.0438 0.3747 0.3747
Trichomonas vaginalis tubulin epsilon chain, putative 0.0178 0.1379 0.7116
Loa Loa (eye worm) hypothetical protein 0.0084 0.0531 0.0531
Toxoplasma gondii alpha tubulin TUBA1 0.0178 0.1379 0.7193
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0096 0.0221
Echinococcus multilocularis Tubulin beta 2C chain 0.0235 0.19 0.4377
Loa Loa (eye worm) jmjC domain-containing protein 0.0131 0.0958 0.0958
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0028 0.0017 0.0024
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0178 0.1379 0.7116
Entamoeba histolytica tubulin alpha-1 chain 0.0178 0.1379 0.7116
Trypanosoma brucei epsilon tubulin 0.0127 0.0921 0.0833
Echinococcus multilocularis beta tubulin 0.0235 0.19 0.4377
Echinococcus granulosus tubulin epsilon chain 0.0127 0.0921 0.2123
Entamoeba histolytica tubulin gamma chain 0.0127 0.0921 0.4576
Echinococcus granulosus tubulin beta 4A class IVa 0.0235 0.19 0.4377
Plasmodium vivax tubulin gamma chain, putative 0.0127 0.0921 0.4801
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0235 0.19 0.4377
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0222 0.0127
Trichomonas vaginalis tubulin, putative 0.0072 0.0419 0.1792
Loa Loa (eye worm) hypothetical protein 0.0114 0.0802 0.0802
Echinococcus multilocularis beta tubulin 0.0235 0.19 0.4377
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0222 0.0697
Echinococcus granulosus Tubulin alpha 1 chain 0.0178 0.1379 0.3179
Schistosoma mansoni tubulin subunit beta 0.0235 0.19 0.2613
Echinococcus granulosus alpha tubulin 0.0178 0.1379 0.3179
Trypanosoma brucei zeta tubulin, putative 0.0055 0.0267 0.0173
Plasmodium vivax tubulin alpha chain, putative 0.0178 0.1379 0.7235
Trichomonas vaginalis tubulin alpha chain, putative 0.0127 0.0921 0.4576
Trichomonas vaginalis tubulin, putative 0.0235 0.19 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0178 0.1379 0.3179
Toxoplasma gondii beta-1 tubulin, putative 0.0235 0.19 1
Trypanosoma brucei beta tubulin 0.0235 0.19 0.1821
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0222 0.0127
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0092 0.0599 0.1381
Brugia malayi Tubulin alpha-2 chain 0.0178 0.1379 0.1379
Loa Loa (eye worm) tubulin alpha-2 chain 0.0178 0.1379 0.1379
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0092 0.0599 0.0599
Leishmania major beta tubulin 0.0235 0.19 0.1821
Trichomonas vaginalis tubulin beta chain, putative 0.0178 0.1379 0.7116
Leishmania major gamma-tubulin 0.0127 0.0921 0.0833
Trypanosoma brucei protein kinase, putative 0.005 0.0222 0.0127
Brugia malayi MAP kinase sur-1 0.005 0.0222 0.0222
Toxoplasma gondii alpha-tubulin I, putative 0.0178 0.1379 0.7193
Leishmania major alpha tubulin 0.0178 0.1379 0.1296
Loa Loa (eye worm) hypothetical protein 0.0084 0.0531 0.0531
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0222 0.0127
Brugia malayi alpha-tubulin 0.0178 0.1379 0.1379
Loa Loa (eye worm) tubulin beta-1 chain 0.0235 0.19 0.19
Loa Loa (eye worm) tubulin alpha 2 0.0122 0.0877 0.0877
Plasmodium falciparum tubulin delta chain, putative 0.0055 0.0267 0.1323
Brugia malayi beta-tubulin, identical 0.0235 0.19 0.19
Leishmania major alpha tubulin 0.0178 0.1379 0.1296
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0058 0.0288 0.0396
Echinococcus multilocularis chromobox protein 2 0.0189 0.1482 0.3414
Loa Loa (eye worm) hypothetical protein 0.0086 0.0549 0.0549
Brugia malayi Tubulin beta-1 chain 0.0235 0.19 0.19
Loa Loa (eye worm) tubulin alpha 2 0.0122 0.0877 0.0877
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0092 0.0599 0.1381
Echinococcus granulosus tubulin alpha 3 chain 0.0178 0.1379 0.3179
Toxoplasma gondii beta tubulin 0.0235 0.19 1
Toxoplasma gondii beta-tubulin, putative 0.0235 0.19 1
Schistosoma mansoni tubulin subunit beta 0.0235 0.19 0.2613
Toxoplasma gondii peptidase family M13 protein 0.0114 0.0802 0.4075
Loa Loa (eye worm) hypothetical protein 0.0575 0.4996 0.4996
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0222 0.0305
Giardia lamblia Epsilon tubulin 0.0055 0.0267 0.0269
Trichomonas vaginalis tubulin epsilon chain, putative 0.0178 0.1379 0.7116
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0106 0.0725 0.3487
Entamoeba histolytica tubulin family protein 0.0235 0.19 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0058 0.0288 0.0396
Brugia malayi mbt repeat family protein 0.0265 0.2174 0.2174
Echinococcus multilocularis peroxisome assembly protein 26 0.0178 0.1379 0.3179
Echinococcus multilocularis tubulin alpha 0.0127 0.0921 0.2123
Giardia lamblia Beta tubulin 0.0235 0.19 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0235 0.19 0.19
Leishmania major beta tubulin 0.0235 0.19 0.1821
Leishmania major zeta tubulin, putative 0.0055 0.0267 0.0173
Echinococcus multilocularis Tubulin beta 2C chain 0.0235 0.19 0.4377
Trichomonas vaginalis tubulin beta chain, putative 0.0072 0.0419 0.1792
Plasmodium vivax tubulin beta chain, putative 0.0235 0.19 1
Leishmania major alpha tubulin 0.0178 0.1379 0.1296
Giardia lamblia Alpha-tubulin 0.0178 0.1379 0.69
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.0314 0.2616 0.6027
Echinococcus granulosus tubulin alpha 0.0127 0.0921 0.2123
Trichomonas vaginalis tubulin gamma chain, putative 0.0235 0.19 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0531 0.0531
Schistosoma mansoni hypothetical protein 0.003 0.0035 0.0048
Mycobacterium tuberculosis Cell division protein FtsZ 0.0055 0.0267 0.2777
Leishmania major alpha tubulin 0.0178 0.1379 0.1296
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0109 0.0759 0.1748
Leishmania major beta tubulin 0.0235 0.19 0.1821
Plasmodium vivax tubulin alpha chain, putative 0.0178 0.1379 0.7235
Leishmania major beta tubulin 0.0235 0.19 0.1821
Loa Loa (eye worm) hypothetical protein 0.0086 0.0549 0.0549
Trichomonas vaginalis tubulin, putative 0.0072 0.0419 0.1792
Brugia malayi Cell division protein ftsZ 0.0055 0.0267 0.0267
Loa Loa (eye worm) peptidase family M13 containing protein 0.0084 0.0531 0.0531
Trypanosoma cruzi tubulin delta chain 0.0055 0.0267 0.0173
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0055 0.0267 0.1189
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0267 0.0948
Plasmodium vivax tubulin epsilon chain, putative 0.0127 0.0921 0.4801
Echinococcus granulosus tubulin alpha 3 chain 0.0178 0.1379 0.3179
Leishmania major alpha tubulin 0.0178 0.1379 0.1296
Trichomonas vaginalis tubulin beta chain, putative 0.0178 0.1379 0.7116
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0222 0.0127
Leishmania major epsilon tubulin, putative 0.0127 0.0921 0.0833
Schistosoma mansoni hypothetical protein 0.003 0.0035 0.0048
Brugia malayi Tubulin gamma chain 0.0127 0.0921 0.0921
Loa Loa (eye worm) hypothetical protein 0.0086 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0114 0.0802 0.0802
Echinococcus multilocularis histone acetyltransferase MYST2 0.0092 0.0599 0.1381
Schistosoma mansoni myelin transcription factor 1 myt1 0.0092 0.0599 0.0825
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.1864 0.1864
Brugia malayi mbt repeat family protein 0.0438 0.3747 0.3747
Loa Loa (eye worm) inositol-1 0.0036 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0092 0.0599 0.0599
Schistosoma mansoni tubulin subunit delta 0.0055 0.0267 0.0367
Schistosoma mansoni tubulin subunit alpha 0.0055 0.0267 0.0367
Echinococcus multilocularis Tubulin alpha 1 chain 0.0178 0.1379 0.3179
Brugia malayi Tubulin alpha-2 chain 0.0178 0.1379 0.1379
Echinococcus granulosus expressed protein 0.0368 0.3113 0.7173
Trypanosoma brucei C-8 sterol isomerase, putative 0.1126 1 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0074 0.044 0.1014
Echinococcus granulosus Tubulin beta 2C chain 0.0235 0.19 0.4377
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0503 0.434 1
Echinococcus granulosus lysine specific demethylase 5A 0.0089 0.0575 0.1325
Loa Loa (eye worm) hypothetical protein 0.1126 1 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0222 0.0697
Trichomonas vaginalis tubulin alpha chain, putative 0.0072 0.0419 0.1792
Trichomonas vaginalis tubulin gamma chain, putative 0.0127 0.0921 0.4576
Trichomonas vaginalis tubulin beta chain, putative 0.0235 0.19 1
Leishmania major alpha tubulin 0.0178 0.1379 0.1296
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0028 0.0017 0.0024
Trichomonas vaginalis tubulin alpha chain, putative 0.0235 0.19 1
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0222 0.0511
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1126 1 1
Schistosoma mansoni sex comb on midleg homolog 0.0255 0.208 0.286
Trichomonas vaginalis tubulin epsilon chain, putative 0.0235 0.19 1
Leishmania major beta tubulin 0.0235 0.19 0.1821
Echinococcus granulosus tubulin subunit beta 0.0235 0.19 0.4377
Schistosoma mansoni hypothetical protein 0.0825 0.727 1
Loa Loa (eye worm) BEN-1 protein 0.0235 0.19 0.19
Schistosoma mansoni phd finger protein 0.0039 0.0119 0.0164
Brugia malayi Peptidase family M13 containing protein 0.0114 0.0802 0.0802
Echinococcus multilocularis Tubulin beta 2C chain 0.0235 0.19 0.4377
Brugia malayi Tubulin beta chain 0.0055 0.0267 0.0267
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.0017 0.0024
Echinococcus multilocularis tubulin alpha chain 0.0178 0.1379 0.3179
Echinococcus multilocularis tubulin epsilon chain 0.0127 0.0921 0.2123
Echinococcus granulosus tubulin alpha chain 0.0178 0.1379 0.3179
Trypanosoma cruzi zeta tubulin, putative 0.0055 0.0267 0.0173
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0109 0.0759 0.1748
Loa Loa (eye worm) hypothetical protein 0.0086 0.0549 0.0549
Brugia malayi tubulin alpha-2 chain 0.0178 0.1379 0.1379
Loa Loa (eye worm) MBCTL1 0.0092 0.0599 0.0599
Echinococcus multilocularis Tubulin beta 2C chain 0.0235 0.19 0.4377
Leishmania major beta tubulin 0.0235 0.19 0.1821
Loa Loa (eye worm) tubulin beta chain 0.0055 0.0267 0.0267
Leishmania major beta tubulin 0.0235 0.19 0.1821
Loa Loa (eye worm) tubulin alpha 2 0.005 0.0223 0.0223
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0222 0.0511
Trypanosoma brucei epsilon tubulin 0.0127 0.0921 0.0833
Echinococcus multilocularis tubulin alpha chain 0.0178 0.1379 0.3179
Echinococcus granulosus endothelin converting enzyme 1 0.0114 0.0802 0.1847
Brugia malayi Inositol-1 0.0036 0.0096 0.0096
Plasmodium falciparum tubulin beta chain 0.0235 0.19 1
Leishmania major beta tubulin 0.0235 0.19 0.1821
Echinococcus granulosus tubulin alpha 1C chain 0.0178 0.1379 0.3179
Entamoeba histolytica tubulin alpha chain, putative 0.0178 0.1379 0.7116
Leishmania major beta tubulin 0.0235 0.19 0.1821
Giardia lamblia Beta tubulin 0.0235 0.19 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0096 0.0132
Echinococcus granulosus Tubulin beta 2C chain 0.0235 0.19 0.4377
Leishmania major beta tubulin 0.0235 0.19 0.1821
Echinococcus multilocularis tubulin gamma 1 chain 0.0127 0.0921 0.2123
Loa Loa (eye worm) tubulin gamma chain 0.0127 0.0921 0.0921
Schistosoma mansoni neprilysin 0.003 0.0035 0.0048
Schistosoma mansoni hypothetical protein 0.003 0.0035 0.0048
Schistosoma mansoni alpha tubulin 0.0178 0.1379 0.1897
Echinococcus multilocularis tubulin delta chain 0.0055 0.0267 0.0615
Schistosoma mansoni chromobox protein 0.0189 0.1482 0.2038
Echinococcus multilocularis histone acetyltransferase myst3 0.0039 0.0119 0.0275
Echinococcus multilocularis tubulin subunit beta 0.0235 0.19 0.4377
Echinococcus granulosus tubulin alpha chain 0.0178 0.1379 0.3179
Echinococcus granulosus histone acetyltransferase myst3 0.0039 0.0119 0.0275
Giardia lamblia Delta tubulin 0.0055 0.0267 0.0269
Echinococcus granulosus chromobox protein 2 0.0189 0.1482 0.3414
Leishmania major beta tubulin 0.0235 0.19 0.1821
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0222 0.0945
Loa Loa (eye worm) tubulin beta-4 chain 0.0235 0.19 0.19
Loa Loa (eye worm) peptidase family M13 containing protein 0.0084 0.0531 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0267 0.0948
Loa Loa (eye worm) hypothetical protein 0.0084 0.0531 0.0531
Loa Loa (eye worm) alpha-tubulin 0.0178 0.1379 0.1379
Echinococcus multilocularis tubulin alpha chain 0.0178 0.1379 0.3179
Schistosoma mansoni tubulin subunit beta 0.0235 0.19 0.2613
Loa Loa (eye worm) tubulin alpha-3 chain 0.0106 0.0725 0.0725
Trichomonas vaginalis tubulin epsilon chain, putative 0.0055 0.0267 0.0948
Loa Loa (eye worm) hypothetical protein 0.0114 0.0802 0.0802
Echinococcus granulosus tubulin beta 1 chain 0.0235 0.19 0.4377
Trypanosoma brucei beta tubulin 0.0235 0.19 0.1821
Plasmodium falciparum tubulin epsilon chain, putative 0.0127 0.0921 0.4801
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0503 0.434 1
Schistosoma mansoni hypothetical protein 0.0314 0.2616 0.3598
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0127 0.0921 0.4721
Schistosoma mansoni tubulin subunit beta 0.0235 0.19 0.2613
Plasmodium falciparum alpha tubulin 2 0.0178 0.1379 0.7235
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0122 0.0877 0.4331
Loa Loa (eye worm) hypothetical protein 0.0122 0.0877 0.0877
Brugia malayi peptidase family M13 containing protein 0.0028 0.0017 0.0017
Echinococcus multilocularis expressed protein 0.0368 0.3113 0.7173
Echinococcus multilocularis tubulin alpha 1C chain 0.0178 0.1379 0.3179
Schistosoma mansoni neprilysin-2 (M13 family) 0.0058 0.0288 0.0396
Trichomonas vaginalis tubulin gamma chain, putative 0.0127 0.0921 0.4576
Schistosoma mansoni hypothetical protein 0.003 0.0035 0.0048
Echinococcus granulosus tubulin alpha chain 0.0178 0.1379 0.3179
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0222 0.0127
Loa Loa (eye worm) tubulin alpha chain 0.0178 0.1379 0.1379
Trypanosoma brucei beta tubulin 0.0235 0.19 0.1821
Schistosoma mansoni alpha tubulin 0.0178 0.1379 0.1897
Echinococcus multilocularis hypothetical protein 0.0178 0.1379 0.3179
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0031 0.0031
Schistosoma mansoni jumonji/arid domain-containing protein 0.0089 0.0575 0.0791
Echinococcus multilocularis tubulin beta 1 chain 0.0235 0.19 0.4377
Loa Loa (eye worm) tubulin beta chain 0.0235 0.19 0.19
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0222 0.0697

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.72 uM Tested for inhibitory concentration against human Endothelin-converting enzyme 1 at 10 microM ChEMBL. 12067547
IC50 (binding) = 0.72 uM Tested for inhibitory concentration against human Endothelin-converting enzyme 1 at 10 microM ChEMBL. 12067547

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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