Detailed information for compound 674500

Basic information

Technical information
  • TDR Targets ID: 674500
  • Name: N-[4-(4-butanoylpiperazin-1-yl)-3-chloropheny l]-2-(2-nitrophenoxy)acetamide
  • MW: 460.911 | Formula: C22H25ClN4O5
  • H donors: 1 H acceptors: 4 LogP: 3.47 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)N1CCN(CC1)c1ccc(cc1Cl)NC(=O)COc1ccccc1[N+](=O)[O-]
  • InChi: 1S/C22H25ClN4O5/c1-2-5-22(29)26-12-10-25(11-13-26)18-9-8-16(14-17(18)23)24-21(28)15-32-20-7-4-3-6-19(20)27(30)31/h3-4,6-9,14H,2,5,10-13,15H2,1H3,(H,24,28)
  • InChiKey: QAYPEJBOYOUPRV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-(4-butanoylpiperazin-1-yl)-3-chloro-phenyl]-2-(2-nitrophenoxy)acetamide
  • N-[3-chloro-4-[4-(1-oxobutyl)-1-piperazinyl]phenyl]-2-(2-nitrophenoxy)acetamide
  • N-[4-(4-butyrylpiperazin-1-yl)-3-chloro-phenyl]-2-(2-nitrophenoxy)acetamide
  • N-[4-(4-butanoylpiperazin-1-yl)-3-chloro-phenyl]-2-(2-nitrophenoxy)ethanamide
  • STK138294

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0019 0.0023
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0225 0.2782
Loa Loa (eye worm) hypothetical protein 0.0031 0.0266 0.0266
Brugia malayi MH1 domain containing protein 0.0008 0.0025 0.0086
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0053 0.0184
Schistosoma mansoni hypothetical protein 0.0008 0.0024 0.0029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0225 0.0225
Brugia malayi Inositol-1 0.0077 0.076 0.2642
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.0674 0.0818
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Brugia malayi Latrophilin receptor protein 2 0.0069 0.0674 0.2343
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.0628 0.0762
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0053 0.0064
Brugia malayi Smad1 0.0008 0.0025 0.0086
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0053 0.0064
Brugia malayi Melatonin receptor type 1A 0.0064 0.0628 0.2182
Schistosoma mansoni hypothetical protein 0.0148 0.1528 0.1854
Brugia malayi Cytochrome P450 family protein 0.0008 0.0018 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1867 0.6487
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0179 0.5138
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0266 0.3501
Echinococcus multilocularis musashi 0.0027 0.0225 0.0274
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0008 0.0024 0.0317
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.0628 0.0762
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0595 0.7822
Brugia malayi CXXC zinc finger family protein 0.003 0.0265 0.092
Brugia malayi Tachykinin-like peptides receptor 99D 0.0064 0.0628 0.2182
Schistosoma mansoni neuropeptide receptor 0.0064 0.0628 0.0762
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0025 0.003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0053 0.0157
Mycobacterium tuberculosis Probable monophosphatase 0.0008 0.0024 0.0086
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0039 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0053 0.0053
Onchocerca volvulus 0.0064 0.0628 0.3276
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0008 0.0018 0.0243
Brugia malayi HMG box family protein 0.0064 0.062 0.2154
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.0053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0053 0.0064
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus granulosus fmrfamide receptor 0.0064 0.0628 0.0762
Echinococcus granulosus cytochrome P450 2K1 0.0008 0.0018 0.0022
Schistosoma mansoni amine GPCR 0.0064 0.0628 0.0762
Echinococcus multilocularis inositol monophosphatase 0.0008 0.0024 0.0029
Brugia malayi hypothetical protein 0.0064 0.0628 0.2182
Echinococcus multilocularis cpg binding protein 0.0032 0.0283 0.0344
Schistosoma mansoni opsin-like receptor 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2877 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0053 0.0064
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0064 0.0628 0.0762
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0053 0.0064
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0164 0.4309
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0327 0.3441 0.3441
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0064 0.0628 0.0628
Brugia malayi latrophilin 2 splice variant baaae 0.0148 0.1528 0.5311
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0204 0.2502
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0628 0.0762
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0179 0.0179
Echinococcus granulosus snurportin 1 0.0327 0.3441 0.4176
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Brugia malayi GnHR receptor homolog 0.0064 0.0628 0.2182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.0628 0.0762
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0179 0.2361
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0053 0.0064
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0008 0.0024 0.0084
Schistosoma mansoni inositol monophosphatase 0.0077 0.076 0.0922
Echinococcus granulosus microtubule associated protein 2 0.0774 0.8241 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.1464 0.1776
Schistosoma mansoni cpg binding protein 0.0032 0.0283 0.0344
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0012 0.0042
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0064 0.0628 0.3276
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0053 0.0064
Brugia malayi hypothetical protein 0.0064 0.0628 0.2182
Echinococcus multilocularis fmrfamide receptor 0.0064 0.0628 0.0762
Brugia malayi neuropeptide F receptor 0.0064 0.0628 0.2182
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1867 0.6487
Leishmania major cytochrome p450-like protein 0.0008 0.0018 0.0243
Echinococcus granulosus tachykinin peptides receptor 99D 0.0064 0.0628 0.0762
Brugia malayi putative neuropeptide receptor NPR1 0.0064 0.0628 0.2182
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Onchocerca volvulus 0.003 0.0265 0.1306
Echinococcus granulosus 7TM GPCR rhodopsin 0.0064 0.0628 0.0762
Echinococcus multilocularis geminin 0.018 0.1867 0.2265
Schistosoma mansoni hypothetical protein 0.0434 0.4593 0.5574
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2877 1
Schistosoma mansoni hypothetical protein 0.0069 0.0674 0.0818
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0069 0.0674 1
Brugia malayi Cytochrome P450 family protein 0.0017 0.0118 0.0411
Echinococcus multilocularis dro:myosuppressin receptor 0.0064 0.0628 0.0762
Leishmania major cytochrome p450-like protein 0.0008 0.0018 0.0243
Loa Loa (eye worm) inositol-1 0.0077 0.076 0.076
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0077 0.076 1
Onchocerca volvulus Glucosylceramidase homolog 0.018 0.1867 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus multilocularis inositol monophosphatase 1 0.0077 0.076 0.0922
Brugia malayi ORL1-like opioid receptor 0.0064 0.0628 0.2182
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0118 0.1345
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0387 0.0469
Echinococcus multilocularis allatostatin A receptor 0.0064 0.0628 0.0762
Echinococcus multilocularis G protein coupled receptor 139 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.0053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Echinococcus granulosus g-protein coupled receptor 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.0053
Brugia malayi hypothetical protein 0.0064 0.0628 0.2182
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.0628 0.0628
Echinococcus multilocularis neuropeptide receptor A26 0.0552 0.5864 0.7116
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0053 0.0184
Schistosoma mansoni neuropeptide receptor 0.0064 0.0628 0.0762
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0042
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0217 0.2264 0.2264
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0042
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus granulosus hypothetical protein 0.0064 0.0628 0.0762
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0017 0.0118 0.1345
Echinococcus multilocularis sex peptide receptor 0.0064 0.0628 0.0762
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0053 0.0064
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.0628 0.0762
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0064 0.0628 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0053 0.0184
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2877 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0024
Brugia malayi Dopamine receptor protein 2 0.0064 0.0628 0.2182
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Schistosoma mansoni myosin xvIII 0.0064 0.0628 0.0762
Schistosoma mansoni importin beta-1 0.0031 0.0266 0.0323
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0265 0.0265
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.0628 0.0762
Onchocerca volvulus 0.0064 0.0628 0.3276
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0204 0.0709
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.0053
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.076 0.2642
Leishmania major myo-inositol-1 phosphatase, putative 0.0008 0.0024 0.0317
Loa Loa (eye worm) hypothetical protein 0.0938 1 1
Onchocerca volvulus 0.0027 0.0225 0.1093
Echinococcus multilocularis Smad4 0.0008 0.0025 0.003
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0008 0.0024 0.0076
Loa Loa (eye worm) acetyltransferase 0.0142 0.1464 0.1464
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0349 0.4595
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0064 0.0628 0.0762
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0053 0.0157
Schistosoma mansoni amine GPCR 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0026 0.022 0.022
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0349 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0225 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0053 0.0053
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.0628 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0053 0.0184
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0019 0.0023
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0164 0.1965
Echinococcus multilocularis protein pangolin J 0.0064 0.062 0.0752
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.0053
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0077 0.076 1
Echinococcus granulosus orexin receptor type 2 0.0064 0.0628 0.0762
Echinococcus multilocularis beta catenin 0.0095 0.0958 0.1162
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0053 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0053 0.0053
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0053 0.0064
Schistosoma mansoni hypothetical protein 0.0327 0.3441 0.4176
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0064 0.0628 0.0762
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0164 0.2223
Brugia malayi Importin beta-1 subunit 0.0031 0.0266 0.0925
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0008 0.0024 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.0674 0.0818
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0164 0.0571
Echinococcus granulosus neuropeptide s receptor 0.0552 0.5864 0.7116
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.0053
Echinococcus granulosus g protein coupled receptor 0.0064 0.0628 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Schistosoma mansoni alpha-1 adrenergic receptor 0.0064 0.0628 0.0762
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Schistosoma mansoni hypothetical protein 0.0069 0.0674 0.0818
Echinococcus multilocularis neuropeptide receptor 0.0064 0.0628 0.0762
Echinococcus granulosus neuropeptide receptor 0.0064 0.0628 0.0762
Brugia malayi MH2 domain containing protein 0.0008 0.0025 0.0086
Echinococcus multilocularis 0.0008 0.0018 0.0022
Brugia malayi larval opioid receptor 0.0064 0.0628 0.2182
Brugia malayi follicle stimulating hormone receptor 0.0064 0.0628 0.2182
Onchocerca volvulus 0.0064 0.0628 0.3276
Onchocerca volvulus 0.0064 0.0628 0.3276
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0019 0.0023
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.0674 0.2343
Schistosoma mansoni hypothetical protein 0.018 0.1867 0.2265
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0064 0.0628 0.0762
Schistosoma mansoni cpg binding protein 0.0032 0.0283 0.0344
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0064 0.0628 0.0762
Echinococcus granulosus g protein coupled receptor 0.0064 0.0628 0.0762
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0064 0.0628 0.2182
Echinococcus granulosus 7tm_1 domain containing protein 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Toxoplasma gondii exonuclease III APE 0.0021 0.0164 0.216
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0064 0.0628 0.0762
Schistosoma mansoni hypothetical protein 0.0069 0.0674 0.0818
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.0628 0.0762
Echinococcus multilocularis snurportin 1 0.0327 0.3441 0.4176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0628 0.0762
Brugia malayi G-protein coupled receptor 0.0064 0.0628 0.2182
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.076 0.2642
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0628 0.0762
Brugia malayi sulfakinin receptor protein 0.0064 0.0628 0.2182
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.076 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.0674 0.0674
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2877 1
Schistosoma mansoni pap-inositol-14-phosphatase 0.0008 0.0024 0.0029
Onchocerca volvulus 0.0064 0.0628 0.3276
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.0628 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0053 0.0184
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0064 0.062 0.0752
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus multilocularis serotonin receptor 0.0064 0.0628 0.0762
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0266 0.3501
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.0674 0.0818
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0204 0.0709
Brugia malayi hypothetical protein 0.0017 0.0123 0.0428
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0266 0.3501
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1421 0.1724
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.197 0.6848
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0025 0.003
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.0628 0.0762
Schistosoma mansoni myo inositol monophosphatase 0.0008 0.0024 0.0029
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0164 0.4247
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0067 0.0081
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0012 0.0042
Schistosoma mansoni biogenic amine receptor 0.0064 0.0628 0.0762
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0008 0.0024 0.0317
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0064 0.0628 0.0762
Brugia malayi Calcitonin receptor-like protein seb-1 0.0217 0.2264 0.787
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0077 0.076 1
Schistosoma mansoni lamin 0.0027 0.0225 0.0274
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0053 0.0064
Echinococcus granulosus allatostatin A receptor 0.0064 0.0628 0.0762
Trichomonas vaginalis inositol monophosphatase, putative 0.0008 0.0024 0.0084
Trichomonas vaginalis helicase, putative 0.0007 0.0012 0.0042
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0053 0.0064
Echinococcus granulosus hypothetical protein 0.0294 0.3097 0.3758
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0053 0.0064
Brugia malayi ecdysteroid receptor 0.0011 0.0053 0.0184
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0053 0.0053
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0628 0.0762
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0387 0.5087
Brugia malayi Inositol monophosphatase family protein 0.0008 0.0024 0.0084
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0019 0.0023
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.0628 0.0762
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0053 0.0064
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0164 0.216
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.0628 0.0762
Schistosoma mansoni biogenic amine receptor 0.0064 0.0628 0.0762
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0387 0.5087
Echinococcus granulosus beta catenin 0.0095 0.0958 0.1162
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0053 0.0064
Schistosoma mansoni cpg binding protein 0.003 0.0265 0.0321
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0064 0.0628 0.0762
Schistosoma mansoni hypothetical protein 0.0231 0.2421 0.2938
Schistosoma mansoni cytochrome P450 0.0008 0.0018 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0628 0.0762
Loa Loa (eye worm) melatonin receptor type 1A 0.0064 0.0628 0.0628
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2877 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0164 0.1965
Echinococcus granulosus inositol monophosphatase 1 0.0077 0.076 0.0922
Leishmania major GTP-binding protein, putative 0.0023 0.0179 0.2361
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0053 0.0064
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0164 0.0571
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1867 0.6487
Trichomonas vaginalis inositol monophosphatase, putative 0.0008 0.0024 0.0084
Schistosoma mansoni ran 0.0023 0.0179 0.0218
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0018 0.0018
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.0628 0.0762
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.0628 0.0762
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0387 1
Loa Loa (eye worm) HMP-2 protein 0.0095 0.0958 0.0958
Echinococcus granulosus G protein coupled receptor 139 0.0064 0.0628 0.0762
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0053 0.0064
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus multilocularis microtubule associated protein 2 0.0774 0.8241 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0164 0.1965
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0025 0.003
Echinococcus multilocularis neuropeptide s receptor 0.0552 0.5864 0.7116
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0225 0.2782
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0077 0.0093
Onchocerca volvulus 0.0064 0.0628 0.3276
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Brugia malayi Serotonin receptor 0.0064 0.0628 0.2182
Loa Loa (eye worm) hypothetical protein 0.0027 0.0225 0.0225
Leishmania major cytochrome p450-like protein 0.0017 0.0118 0.1555
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0092 0.032
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0092 0.0092
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0053 0.0064
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.0628 0.0762
Toxoplasma gondii cytochrome p450 superfamily protein 0.0008 0.0018 0.0243
Brugia malayi steroid hormone receptor 0.0011 0.0053 0.0184
Trichomonas vaginalis inositol monophosphatase, putative 0.0077 0.076 0.2642
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0179 0.0218
Brugia malayi Serotonin receptor 0.0064 0.0628 0.2182
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.4593 0.5574
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.1464 0.1776
Schistosoma mansoni hypothetical protein 0.018 0.1867 0.2265
Brugia malayi neuropeptide F receptor 0.0064 0.0628 0.2182
Schistosoma mansoni biogenic amine receptor 0.0064 0.0628 0.0762
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1867 0.6487
Onchocerca volvulus 0.0064 0.0628 0.3276
Schistosoma mansoni microtubule-associated protein tau 0.0774 0.8241 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0064 0.0628 0.0762
Brugia malayi Inositol monophosphatase family protein 0.0008 0.0024 0.0084
Onchocerca volvulus Cirhin homolog 0.0094 0.0951 0.5032
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0053 0.0064
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0631 0.0766
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0179 0.4641
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0008 0.0024 0.0029
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0077 0.0093
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0053 0.0064
Echinococcus granulosus smad 0.0008 0.0025 0.003
Brugia malayi nuclear receptor NHR-88 0.0011 0.0053 0.0184
Brugia malayi AKH receptor 0.0064 0.0628 0.2182
Schistosoma mansoni growth hormone secretagogue receptor 0.0064 0.0628 0.0762
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0064 0.0628 0.0628
Schistosoma mansoni hypothetical protein 0.0069 0.0674 0.0818
Brugia malayi hypothetical protein 0.0027 0.0225 0.0781
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0024
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.0628 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0053 0.0184
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0179 0.2171
Brugia malayi RNA, U transporter 1 0.0087 0.0871 0.3028
Echinococcus multilocularis g-protein coupled receptor 0.0064 0.0628 0.0762
Schistosoma mansoni smad1 5 8 and 0.0008 0.0025 0.003
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0053 0.0064
Brugia malayi cytochrome P450 0.0008 0.0018 0.0064
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Onchocerca volvulus 0.0064 0.0628 0.3276
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1211 0.1211
Schistosoma mansoni beta-catenin 0.0095 0.0958 0.1162
Plasmodium falciparum importin beta, putative 0.0031 0.0266 0.7619
Echinococcus granulosus inositol monophosphatase 0.0008 0.0024 0.0029
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Brugia malayi nuclear hormone receptor 0.0011 0.0053 0.0184
Brugia malayi G-protein coupled receptor 0.0064 0.0628 0.2182
Echinococcus granulosus g protein coupled receptor 0.0064 0.0628 0.0762
Schistosoma mansoni adenoreceptor 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0009 0.0038 0.0038
Echinococcus granulosus neuropeptide receptor A26 0.0552 0.5864 0.7116
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.0628 0.0762
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0204 0.0709
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0053 0.0157
Echinococcus multilocularis GPCR, family 2 0.0069 0.0674 0.0818
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0039 0.0047
Onchocerca volvulus 0.0011 0.0053 0.0157
Echinococcus multilocularis smad 0.0008 0.0025 0.003
Schistosoma mansoni smad1 5 8 and 0.0008 0.0025 0.003
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0064 0.0628 0.2182
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0628 0.0762
Schistosoma mansoni neuropeptide f receptor 76f 0.0064 0.0628 0.0762
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0053 0.0064
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0077 0.076 1
Echinococcus multilocularis neuropeptide receptor 0.0064 0.0628 0.0762
Onchocerca volvulus 0.0064 0.0628 0.3276
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0025 0.003
Brugia malayi hypothetical protein 0.0064 0.0628 0.2182
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0008 0.0024 0.0076
Onchocerca volvulus 0.0064 0.0628 0.3276
Onchocerca volvulus 0.0064 0.0628 0.3276
Entamoeba histolytica hypothetical protein 0.0025 0.0204 0.2684
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0266 0.0323
Plasmodium vivax importin-beta 2, putative 0.0031 0.0266 0.6882
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0053 0.0064
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0274 0.2877 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0118 0.0118
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0053 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0053 0.0184
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0164 0.0199
Echinococcus multilocularis neuropeptide FF receptor 2 0.0064 0.0628 0.0762
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0628 0.0762
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0225 0.6437
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0225 0.0784
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.0628 0.0762
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0067 0.0081
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.076 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0064 0.0628 0.0762
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0164 0.0199
Onchocerca volvulus 0.0064 0.0628 0.3276
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.0628 0.0762
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0349 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0274 0.2877 0.2877
Schistosoma mansoni hypothetical protein 0.0012 0.0067 0.0081
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0069 0.0674 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0064 0.0628 0.0628
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0628 0.0762
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0053 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0053 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0053 0.0184
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0053 0.0064
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0013 0.0077 0.0077
Schistosoma mansoni lamin 0.0027 0.0225 0.0274
Schistosoma mansoni smad1 5 8 and 0.0008 0.0025 0.003
Brugia malayi hypothetical protein 0.0064 0.0628 0.2182
Schistosoma mansoni ap endonuclease 0.0021 0.0164 0.0199
Brugia malayi Dopamine receptor protein 1 0.0064 0.0628 0.2182
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0053 0.0184
Echinococcus granulosus GPCR family 2 0.0069 0.0674 0.0818
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1867 0.6487
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0053 0.0064
Echinococcus granulosus neuropeptide FF receptor 2 0.0064 0.0628 0.0762
Brugia malayi RE15519p 0.0064 0.0628 0.2182
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0053 0.0184
Schistosoma mansoni opsin-like receptor 0.0064 0.0628 0.0762
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0053 0.0064
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0025 0.0025
Schistosoma mansoni pangolin 0.0064 0.062 0.0752
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0064 0.0628 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0064 0.0628 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0053 0.0184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0628 0.0762
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0064 0.0628 0.0762
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0064 0.0628 0.0762
Onchocerca volvulus 0.0064 0.0628 0.3276
Loa Loa (eye worm) Smad1 0.0008 0.0025 0.0025
Echinococcus granulosus somatostatin receptor 0.0064 0.0628 0.0762
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0053 0.0064
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.0628 0.0628
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0064 0.062 0.0752
Onchocerca volvulus 0.0027 0.0225 0.1093
Onchocerca volvulus 0.0064 0.0628 0.3276
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0011 0.0053 0.0053
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.0628 0.0762
Mycobacterium ulcerans monophosphatase CysQ 0.0008 0.0024 0.0076
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.1464 0.5088
Brugia malayi Cytochrome P450 family protein 0.0008 0.0018 0.0064
Schistosoma mansoni hypothetical protein 0.0008 0.0018 0.0022
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.0628 0.0628
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0225 0.6437
Schistosoma mansoni Smad4 0.0008 0.0025 0.003
Brugia malayi hypothetical protein 0.0064 0.0628 0.2182
Entamoeba histolytica Ran family GTPase 0.0023 0.0179 0.2361
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.0628 0.0762
Leishmania major importin beta-1 subunit, putative 0.0025 0.0204 0.2684
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0064 0.0628 0.0628
Echinococcus multilocularis orexin receptor type 2 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0217 0.2264 0.2264
Schistosoma mansoni ap endonuclease 0.0021 0.0164 0.0199
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0038 0.0131
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0064 0.0628 0.2182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Echinococcus multilocularis somatostatin receptor 0.0064 0.0628 0.0762
Loa Loa (eye worm) cytochrome P450 0.0008 0.0018 0.0018
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0008 0.0024 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0387 0.1344
Echinococcus granulosus intermediate filament protein 0.0027 0.0225 0.0274
Schistosoma mansoni opsin-like receptor 0.0064 0.0628 0.0762
Echinococcus granulosus lamin dm0 0.0027 0.0225 0.0274
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0042
Echinococcus granulosus lamin 0.0027 0.0225 0.0274
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0179 0.0624
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0064 0.0628 0.0762
Loa Loa (eye worm) HMG box family protein 0.0064 0.062 0.062
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0179 0.0218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0628 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Schistosoma mansoni hypothetical protein 0.0064 0.0628 0.0762
Mycobacterium leprae Probable monophosphatase 0.0008 0.0024 0.0086
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0064 0.0628 0.0762
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.197 0.6848
Trichomonas vaginalis ran, putative 0.0023 0.0179 0.0624
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0064 0.0628 0.0762
Echinococcus multilocularis lamin dm0 0.0027 0.0225 0.0274
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0064 0.0628 0.0628
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Schistosoma mansoni hypothetical protein 0.0008 0.0024 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0628 0.0762
Schistosoma mansoni hypothetical protein 0.0064 0.0628 0.0762
Mycobacterium tuberculosis Monophosphatase CysQ 0.0008 0.0024 0.0086
Schistosoma mansoni smad 0.0008 0.0025 0.003
Onchocerca volvulus 0.0064 0.0628 0.3276
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0179 0.4778
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0064 0.0628 0.0762
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0053 0.0064
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0225 0.5814
Schistosoma mansoni amine GPCR 0.0064 0.0628 0.0762
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0164 0.0571
Loa Loa (eye worm) TYRA-2 protein 0.0064 0.0628 0.0628
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0179 0.2361
Mycobacterium ulcerans monophosphatase 0.0008 0.0024 0.0076
Onchocerca volvulus 0.0064 0.0628 0.3276
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0118 0.1555
Schistosoma mansoni histamine h1 receptor 0.0064 0.0628 0.0762
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0179 0.2171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Echinococcus multilocularis serotonin receptor 0.0064 0.0628 0.0762
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0053 0.0184
Brugia malayi putative neuropeptide receptor 0.0064 0.0628 0.2182
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0025 0.003
Echinococcus granulosus cpg binding protein 0.0032 0.0283 0.0344
Brugia malayi hypothetical protein 0.0064 0.0628 0.2182
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.0628 0.0628
Brugia malayi hypothetical protein 0.0064 0.0628 0.2182
Schistosoma mansoni amine GPCR 0.0064 0.0628 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0053 0.0184
Loa Loa (eye worm) hypothetical protein 0.0069 0.0674 0.0674
Leishmania major hypothetical protein, conserved 0.0027 0.0225 0.2958
Echinococcus multilocularis lamin 0.0027 0.0225 0.0274
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1211 0.1211
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0118 0.0118
Brugia malayi G protein-coupled receptor 0.0064 0.0628 0.2182
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0008 0.0024 0.0317
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Brugia malayi MH2 domain containing protein 0.0119 0.1211 0.4208
Echinococcus granulosus geminin 0.018 0.1867 0.2265
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0225 0.2958
Echinococcus granulosus neuropeptide receptor 0.0064 0.0628 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0064 0.0628 0.0762
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0053 0.0064
Schistosoma mansoni inositol monophosphatase 0.0077 0.076 0.0922
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus granulosus sex peptide receptor 0.0064 0.0628 0.0762
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1867 0.6487
Brugia malayi MH1 domain containing protein 0.0008 0.0025 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Onchocerca volvulus Neuropeptide F receptor homolog 0.0064 0.0628 0.3276
Schistosoma mansoni neuropeptide receptor 0.0064 0.0628 0.0762
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0042
Brugia malayi hypothetical protein 0.0064 0.0628 0.2182
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0387 0.1344
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.076 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0164 0.216
Echinococcus granulosus dro:myosuppressin receptor 0.0064 0.0628 0.0762
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0008 0.0024 0.0029
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0095 0.0958 0.333
Schistosoma mansoni hypothetical protein 0.0064 0.0628 0.0762
Echinococcus granulosus alpha 1A adrenergic receptor 0.0064 0.0628 0.0762
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.0628 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0053 0.0184
Schistosoma mansoni amine GPCR 0.0064 0.0628 0.0762
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0118 0.1345
Loa Loa (eye worm) hypothetical protein 0.0148 0.1528 0.1528
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0225 0.2958
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0118 0.0118
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0217 0.2264 0.787
Schistosoma mansoni neuropeptide receptor 0.0064 0.0628 0.0762
Echinococcus multilocularis fmrfamide receptor 0.0064 0.0628 0.0762
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0164 0.216
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0008 0.0018 0.0243
Echinococcus granulosus serotonin receptor 0.0064 0.0628 0.0762
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0164 0.5
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.076 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.0674 0.0818
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0053 0.0184
Echinococcus multilocularis G-protein coupled receptor, putative 0.0064 0.0628 0.0762
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0225 0.0225
Brugia malayi G protein-coupled receptor F59B2.13 0.0064 0.0628 0.2182
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Brugia malayi Dopamine receptor 0.0064 0.0628 0.2182
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0064 0.0628 0.0762
Onchocerca volvulus 0.0064 0.0628 0.3276
Brugia malayi MH2 domain containing protein 0.0008 0.0025 0.0086
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0039 0.0039
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0064 0.0628 0.2182
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1867 0.6487
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0628 0.0762
Mycobacterium ulcerans monophosphatase CysQ 0.0008 0.0024 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2877 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0628 0.0762
Toxoplasma gondii hypothetical protein 0.0008 0.0024 0.0317
Brugia malayi Cytochrome P450 family protein 0.0017 0.0118 0.0411
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0008 0.0024 0.0317
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.0628 0.0762
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0053 0.0053
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0008 0.0024 0.0076
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0008 0.0024 0.0317
Brugia malayi hypothetical protein 0.0064 0.0628 0.2182
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0064 0.0628 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0164 0.0164
Echinococcus granulosus dnaJ subfamily B 0.0434 0.4593 0.5574
Mycobacterium leprae POSSIBLE MONOPHOSPHATASE CYSQ 0.0008 0.0024 0.0086
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0628 0.0762
Echinococcus granulosus pangolin 0.0064 0.062 0.0752
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.0628 0.0762
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0164 0.4701
Brugia malayi intermediate filament protein 0.0027 0.0225 0.0784
Schistosoma mansoni coup transcription factor 0.0011 0.0053 0.0064
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0053 0.0053
Schistosoma mansoni ran 0.0023 0.0179 0.0218
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0064 0.0628 0.2182
Loa Loa (eye worm) hypothetical protein 0.0064 0.0628 0.0628
Echinococcus granulosus importin subunit beta 1 0.0031 0.0266 0.0323
Schistosoma mansoni hypothetical protein 0.0064 0.0628 0.0762
Echinococcus granulosus Smad4 0.0008 0.0025 0.003

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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