Detailed information for compound 68512

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 255.272 | Formula: C14H13N3O2
  • H donors: 1 H acceptors: 3 LogP: 1.42 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCn1ccc(=O)n2c1cc(n2)c1ccccc1
  • InChi: 1S/C14H13N3O2/c18-9-8-16-7-6-14(19)17-13(16)10-12(15-17)11-4-2-1-3-5-11/h1-7,10,18H,8-9H2
  • InChiKey: FPXYUOPEONZNHW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.1243 0.1243
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0488 1 1
Loa Loa (eye worm) cytochrome P450 0.0026 0.0465 0.0457
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0026 0.0465 0.0457
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.112 0.1112
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0253 0.0244
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0009 0.0009
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0116 0.0108
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0333 0.0325
Loa Loa (eye worm) hypothetical protein 0.0005 0.0034 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0026 0.0465 0.0457
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0333 0.0333
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0333 0.0331
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0353 0.0344
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.067 0.0661
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0026 0.0465 0.0457
Schistosoma mansoni cpg binding protein 0.0032 0.0583 0.0583
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0488 1 1
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0488 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0333 0.0325
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0026 0.0465 0.0457
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0253 0.0244
Plasmodium falciparum eukaryotic initiation factor 4A 0.0488 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.1094 0.1086
Onchocerca volvulus 0.0021 0.0353 0.0344
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0253 0.0244
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0333 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0065
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0253 0.0244
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0081 0.0072
Trichomonas vaginalis helicase, putative 0.0007 0.0067 0.0065
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0353 0.0344
Schistosoma mansoni cript-related 0.0004 0.0009 0.0009
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0026 0.0465 0.2626
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0837 0.0829
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0081 0.0072
Brugia malayi Cytochrome P450 family protein 0.0044 0.0837 0.0829
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0026 0.0465 0.0457
Schistosoma mansoni lipoxygenase 0.0058 0.112 0.112
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0119 0.011
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0026 0.0465 0.2626
Schistosoma mansoni ap endonuclease 0.002 0.0333 0.0333
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0333 0.0325
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0353 0.0344
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0081 0.0072
Loa Loa (eye worm) pax transcription factor protein 2 0.0271 0.5518 0.5514
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0465 0.0457
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0004 0.0009 0.0007
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0009 0.0009
Onchocerca volvulus 0.0005 0.0034 0.0025
Onchocerca volvulus Retinal homeobox protein Rx homolog 0.0005 0.0034 0.0025
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1102 0.1095
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0488 1 1
Brugia malayi CXXC zinc finger family protein 0.003 0.0547 0.0539
Echinococcus granulosus Ankyrin 0.0014 0.0226 0.0217
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0026 0.0465 0.2626
Echinococcus granulosus paired box protein pax 6 0.0005 0.0034 0.0025
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0253 0.0244
Schistosoma mansoni paired box protein pax-1-related 0.0005 0.0034 0.0034
Trichomonas vaginalis Phospholipase C precursor, putative 0.0004 0.0009 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0065
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0253 0.0244
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0224 0.0215
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0026 0.0465 0.0457
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0009 0.0009
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0253 0.0253
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0026 0.0465 0.0457
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0067 0.0065
Echinococcus multilocularis Ankyrin 0.0014 0.0226 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0065
Mycobacterium leprae Conserved hypothetical protein 0.0026 0.0465 0.5
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0026 0.0465 0.2626
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.8765 0.8764
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0026 0.0465 0.0457
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0065
Brugia malayi vab-3 gene. 0.0005 0.0034 0.0025
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0026 0.0465 0.2626
Brugia malayi Protein kinase domain containing protein 0.0015 0.0234 0.0226
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.1094 0.1092
Entamoeba histolytica hypothetical protein 0.0036 0.067 0.067
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0026 0.0465 0.0457
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0465 0.0457
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0333 0.5
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0333 0.0325
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.1094 0.1092
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0488 1 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0224 0.0215
Schistosoma mansoni rab6-interacting 0.0021 0.0353 0.0353
Loa Loa (eye worm) CYP4Cod1 0.0044 0.0837 0.0829
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0026 0.0465 0.2626
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0253 0.0244
Trypanosoma brucei cytochrome P450, putative 0.0044 0.0837 0.0829
Loa Loa (eye worm) hypothetical protein 0.0014 0.0226 0.0217
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0488 1 1
Schistosoma mansoni hypothetical protein 0.0169 0.3425 0.3425
Brugia malayi MAP kinase sur-1 0.0056 0.1094 0.1086
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0353 0.0344
Schistosoma mansoni cpg binding protein 0.003 0.0547 0.0547
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0026 0.0465 0.2626
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0026 0.0465 0.2626
Toxoplasma gondii cytochrome p450 superfamily protein 0.0026 0.0465 0.0457
Schistosoma mansoni paired box protein pax-6 0.0005 0.0034 0.0034
Plasmodium vivax RNA helicase-1, putative 0.0488 1 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0253 0.0244
Echinococcus granulosus geminin 0.0169 0.3425 0.3419
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.1094 0.1086
Loa Loa (eye worm) hypothetical protein 0.0005 0.0034 0.0025
Loa Loa (eye worm) vab-3 0.0005 0.0034 0.0025
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0034 0.0025
Brugia malayi Cytochrome P450 family protein 0.0108 0.2148 0.2141
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0034 0.0025
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.1094 0.1092
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0224 0.0224
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0004 0.0009 0.0007
Brugia malayi Uncoordinated protein 44 0.0014 0.0224 0.0215
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0004 0.0009 0.0009
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0253 0.0244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0224 0.0215
Loa Loa (eye worm) hypothetical protein 0.0005 0.0034 0.0025
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0547 0.0539
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0026 0.0465 0.2626
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0004 0.0009 0.0007
Schistosoma mansoni neutral sphingomyelinase 0.0004 0.0009 0.0009
Schistosoma mansoni loxhd1 0.0021 0.0353 0.0353
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.1094 0.1086
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0026 0.0465 0.0457
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0026 0.0465 0.2626
Schistosoma mansoni hypothetical protein 0.0026 0.0465 0.0465
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0488 1 1
Mycobacterium leprae putative cytochrome p450 0.0026 0.0465 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0065
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.1094 0.1086
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0026 0.0465 0.0457
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0026 0.0465 0.2626
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0488 1 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0026 0.0465 0.2626
Echinococcus granulosus paired box protein pax 6 0.0005 0.0034 0.0025
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.1094 0.1086
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.1094 0.1086
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0333 0.0325
Schistosoma mansoni nocturnin 0.0004 0.0009 0.0009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0224 0.0215
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0333 0.0325
Loa Loa (eye worm) paired box protein 0.0005 0.0034 0.0025
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0333 0.0331
Schistosoma mansoni hypothetical protein 0.0014 0.0224 0.0224
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0488 1 1
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0488 1 1
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0004 0.0009 0.0009
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0224 0.0215
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0026 0.0465 0.0457
Trypanosoma cruzi cytochrome P450, putative 0.0044 0.0837 0.0829
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0333 0.0325
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0253 0.0244
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.1094 0.1092
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0488 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0004 0.0002 0.0000000044889
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0065
Brugia malayi Gooseberry protein 0.0005 0.0034 0.0025
Leishmania major cytochrome p450-like protein 0.0044 0.0837 0.0829
Schistosoma mansoni polycystin 1-related 0.0021 0.0353 0.0353
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0253 0.0244
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0026 0.0465 0.0457
Onchocerca volvulus 0.003 0.0547 0.0539
Echinococcus multilocularis paired box protein pax 6 0.0005 0.0034 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0026 0.0465 0.0457
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0224 0.0215
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0837 0.0829
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0253 0.0244
Echinococcus granulosus death domain containing protein 0.0014 0.0224 0.0215
Schistosoma mansoni paired box protein pax-6 0.0005 0.0034 0.0034
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.1094 0.1086
Loa Loa (eye worm) hypothetical protein 0.0021 0.0353 0.0344
Onchocerca volvulus 0.0005 0.0034 0.0025
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.1094 0.1086
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.1094 0.1086
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0065
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0009 0.0009
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0026 0.0465 0.0457
Echinococcus granulosus nuclear factor of activated T cells 5 0.0221 0.4488 0.4483
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0026 0.0465 0.0457
Brugia malayi hypothetical protein 0.0021 0.0353 0.0344
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0044 0.0837 1
Echinococcus granulosus paired box protein pax 1 0.0005 0.0034 0.0025
Schistosoma mansoni hypothetical protein 0.0428 0.8765 0.8765
Brugia malayi paired box protein 0.0005 0.0034 0.0025
Brugia malayi Cytochrome P450 family protein 0.0044 0.0837 0.0829
Onchocerca volvulus 0.0271 0.5518 0.5514
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0081 0.0072
Echinococcus multilocularis paired box protein pax 1 0.0005 0.0034 0.0025
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0353 0.0344
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0488 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0067 0.0065
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0253 0.0244
Entamoeba histolytica hypothetical protein 0.0036 0.067 0.067
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0004 0.0009 0.0009
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.112 0.1112
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0004 0.0009 0.0009
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0009 0.0007
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0333 0.0325
Brugia malayi hypothetical protein 0.0021 0.0353 0.0344
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0065
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0253 0.0244
Echinococcus granulosus dnaJ subfamily B 0.0428 0.8765 0.8764
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0333 0.0325
Brugia malayi cytochrome P450 0.0026 0.0465 0.0457
Trypanosoma cruzi cytochrome P450, putative 0.0044 0.0837 0.0829
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0253 0.0244
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0488 1 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0026 0.0465 0.2626
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0034 0.0025
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0026 0.0465 0.2626
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0026 0.0465 0.2626
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0009 0.0007
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0488 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0065
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.1094 0.1086
Loa Loa (eye worm) hypothetical protein 0.0005 0.0034 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0353 0.0344
Trypanosoma brucei protein kinase, putative 0.0056 0.1094 0.1086
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0026 0.0465 0.2626
Schistosoma mansoni hypothetical protein 0.0169 0.3425 0.3425
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0224 0.0215
Treponema pallidum ATP-dependent RNA helicase 0.0488 1 1
Plasmodium falciparum DNase I-like protein, putative 0.0004 0.0009 0.0009
Schistosoma mansoni netrin receptor unc5 0.0014 0.0224 0.0224
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0488 1 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0026 0.0465 0.0457
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0026 0.0465 0.0457
Leishmania major eukaryotic initiation factor 4a, putative 0.0488 1 1
Brugia malayi Pax transcription factor protein 2 0.0271 0.5518 0.5514
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0353 0.0344
Echinococcus granulosus RUN 0.0021 0.0353 0.0344
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0009 0.0007
Brugia malayi Doublecortin family protein 0.0021 0.0353 0.0344
Leishmania major cytochrome p450-like protein 0.0026 0.0465 0.0457
Onchocerca volvulus 0.0021 0.0353 0.0344
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0253 0.0244
Schistosoma mansoni cytochrome P450 0.0026 0.0465 0.0465
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0004 0.0009 0.0009
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0026 0.0465 0.0457
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.1094 0.1086
Brugia malayi Cytochrome P450 family protein 0.0026 0.0465 0.0457
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.1094 0.1086
Schistosoma mansoni synaptojanin 0.0004 0.0009 0.0009
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0353 0.0344
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0026 0.0465 0.0457
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0488 1 1
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0004 0.0009 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0065
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0253 0.0253
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0488 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.067 0.067
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0333 0.0325
Echinococcus multilocularis 0.0026 0.0465 0.0457
Echinococcus multilocularis paired box protein pax 6 0.0005 0.0034 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0065
Loa Loa (eye worm) hypothetical protein 0.0018 0.0298 0.029
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0224 0.0215
Echinococcus multilocularis RUN 0.0021 0.0353 0.0344
Schistosoma mansoni lipoxygenase 0.0021 0.0353 0.0353
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0221 0.4488 0.4483
Brugia malayi hypothetical protein 0.0036 0.067 0.0661
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0353 0.0344
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0065
Schistosoma mansoni hypothetical protein 0.0021 0.0353 0.0353
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0081 0.0081
Brugia malayi isocitrate dehydrogenase 0.0016 0.0253 0.0244
Schistosoma mansoni paired box protein pax-6 0.0005 0.0034 0.0034
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0026 0.0465 0.2626
Schistosoma mansoni ap endonuclease 0.002 0.0333 0.0333
Echinococcus multilocularis paired box protein pax 6 0.0005 0.0034 0.0025
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0004 0.0009 0.0009
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0026 0.0465 0.2626
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0004 0.0009 0.0009
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0026 0.0465 0.0457
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0004 0.0009 0.0009
Brugia malayi Death domain containing protein 0.0014 0.0224 0.0215
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0119 0.011
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0353 0.0353
Toxoplasma gondii exonuclease III APE 0.002 0.0333 0.0325
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0333 0.0333
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0004 0.0009 0.0009
Schistosoma mansoni carbon catabolite repressor protein 0.0004 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0065
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0026 0.0465 0.2626
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.1094 0.1094
Schistosoma mansoni synaptojanin 0.0004 0.0009 0.0009
Schistosoma mansoni cpg binding protein 0.0032 0.0583 0.0583
Schistosoma mansoni rab6-interacting 0.0021 0.0353 0.0353
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0065
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0333 0.0325
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.1094 0.1086
Echinococcus granulosus cpg binding protein 0.0032 0.0583 0.0574
Echinococcus multilocularis cpg binding protein 0.0032 0.0583 0.0574
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0004 0.0009 0.0009
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0004 0.0009 0.0009
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0119 0.011
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0026 0.0465 0.2626
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0009 0.0009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0253 0.0244
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0026 0.0465 0.0457
Entamoeba histolytica hypothetical protein 0.0036 0.067 0.067
Loa Loa (eye worm) cytochrome P450 family protein 0.0108 0.2148 0.2141
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0226 0.0226
Echinococcus granulosus cytochrome P450 2K1 0.0026 0.0465 0.0457
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0004 0.0009 0.0007
Echinococcus granulosus eukaryotic initiation factor 4A 0.0488 1 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0026 0.0465 0.0457
Schistosoma mansoni hypothetical protein 0.0036 0.067 0.067
Echinococcus granulosus paired box gene 3/7 (eyeless, eyegone, twin of eyeless) 0.0005 0.0034 0.0025
Leishmania major cytochrome p450-like protein 0.0026 0.0465 0.0457
Brugia malayi paired box pox-meso protein 0.0005 0.0034 0.0025
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.1094 0.1086
Leishmania major eukaryotic initiation factor 4a, putative 0.0488 1 1
Echinococcus multilocularis geminin 0.0169 0.3425 0.3419
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.067 0.0661
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.067 0.067

Activities

Activity type Activity value Assay description Source Reference
Reduction (functional) 0 % Percent reduction of edema in rat on 23rd day after oral administration of 30 mg/kg in antiarthritis assay; i = Inactive ChEMBL. 6606043
Reduction (functional) = 16.5 % Percent reduction of edema in mice 3h after oral administration of 30 mg/kg in carrageenin model ChEMBL. 6606043
Reduction (functional) = 16.5 % Percent reduction of edema in mice 3h after oral administration of 30 mg/kg in carrageenin model ChEMBL. 6606043

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.