Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0026 | 0.0465 | 0.2626 |
Brugia malayi | vab-3 gene. | 0.0005 | 0.0034 | 0.0025 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0333 | 0.0333 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0004 | 0.0009 | 0.0007 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0333 | 0.0325 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0026 | 0.0465 | 0.0457 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0488 | 1 | 1 |
Echinococcus granulosus | RUN | 0.0021 | 0.0353 | 0.0344 |
Schistosoma mansoni | lipoxygenase | 0.0058 | 0.112 | 0.112 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0026 | 0.0465 | 0.2626 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0333 | 0.0325 |
Echinococcus granulosus | paired box protein pax 6 | 0.0005 | 0.0034 | 0.0025 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0026 | 0.0465 | 0.0457 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0488 | 1 | 1 |
Brugia malayi | Doublecortin family protein | 0.0021 | 0.0353 | 0.0344 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0081 | 0.0072 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0026 | 0.0465 | 0.2626 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0064 | 0.1243 | 0.1243 |
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.0465 | 0.0457 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0026 | 0.0465 | 0.0457 |
Schistosoma mansoni | loxhd1 | 0.0021 | 0.0353 | 0.0353 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0009 | 0.0007 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0026 | 0.0465 | 0.2626 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0333 | 0.0325 |
Plasmodium falciparum | endonuclease/exonuclease/phosphatase family protein, putative | 0.0004 | 0.0009 | 0.0009 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0067 | 0.0065 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0333 | 0.0333 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0333 | 0.0333 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0253 | 0.0244 |
Plasmodium falciparum | DNase I-like protein, putative | 0.0004 | 0.0009 | 0.0009 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0009 | 0.0007 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0056 | 0.1094 | 0.1086 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.3425 | 0.3425 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0026 | 0.0465 | 0.2626 |
Schistosoma mansoni | hypothetical protein | 0.0428 | 0.8765 | 0.8765 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0488 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0026 | 0.0465 | 0.2626 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0004 | 0.0009 | 0.0007 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase domain containing protein | 0.0004 | 0.0009 | 0.0009 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0026 | 0.0465 | 0.0457 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0253 | 0.0244 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0333 | 0.0325 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0488 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0056 | 0.1094 | 0.1086 |
Schistosoma mansoni | ocrl type II inositol 5-phosphatase | 0.0004 | 0.0009 | 0.0009 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0067 | 0.0065 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0056 | 0.1094 | 0.1086 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0333 | 0.0325 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0067 | 0.0065 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0044 | 0.0837 | 0.0829 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0026 | 0.0465 | 0.2626 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.1094 | 0.1092 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0026 | 0.0465 | 0.2626 |
Onchocerca volvulus | 0.0021 | 0.0353 | 0.0344 | |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0009 | 0.0009 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0253 | 0.0244 |
Brugia malayi | Pax transcription factor protein 2 | 0.0271 | 0.5518 | 0.5514 |
Schistosoma mansoni | polycystin 1-related | 0.0021 | 0.0353 | 0.0353 |
Onchocerca volvulus | Retinal homeobox protein Rx homolog | 0.0005 | 0.0034 | 0.0025 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0333 | 0.0325 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0026 | 0.0465 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0014 | 0.0224 | 0.0215 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0026 | 0.0465 | 0.2626 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.067 | 0.067 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0067 | 0.0065 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0333 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0044 | 0.0837 | 0.0829 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0026 | 0.0465 | 0.0457 |
Schistosoma mansoni | lipoxygenase | 0.0021 | 0.0353 | 0.0353 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0014 | 0.0224 | 0.0215 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0026 | 0.0465 | 0.0457 |
Brugia malayi | paired box pox-meso protein | 0.0005 | 0.0034 | 0.0025 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0026 | 0.0465 | 0.2626 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0026 | 0.0465 | 0.0457 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.067 | 0.067 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0224 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0226 | 0.0217 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0353 | 0.0344 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.0253 | 0.0244 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.1094 | 0.1092 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0253 | 0.0244 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0026 | 0.0465 | 0.0457 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0026 | 0.0465 | 0.0457 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0353 | 0.0344 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0034 | 0.0025 |
Echinococcus granulosus | paired box protein pax 1 | 0.0005 | 0.0034 | 0.0025 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0333 | 0.0325 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0009 | 0.0009 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0044 | 0.0837 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0253 | 0.0244 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0034 | 0.0025 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.1094 | 0.1092 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0488 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0044 | 0.0837 | 0.0829 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0067 | 0.0065 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0488 | 1 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0021 | 0.0353 | 0.0344 |
Brugia malayi | 'Paired box' domain containing protein | 0.0005 | 0.0034 | 0.0025 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0014 | 0.0224 | 0.0215 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0009 | 0.0009 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0488 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0026 | 0.0465 | 0.2626 |
Onchocerca volvulus | Netrin receptor homolog | 0.0014 | 0.0224 | 0.0215 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0026 | 0.0465 | 0.2626 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.0583 | 0.0574 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase domain containing protein | 0.0004 | 0.0009 | 0.0009 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0056 | 0.1094 | 0.1086 |
Schistosoma mansoni | nocturnin | 0.0004 | 0.0009 | 0.0009 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0253 | 0.0244 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.067 | 0.067 |
Plasmodium falciparum | exodeoxyribonuclease III, putative | 0.0004 | 0.0009 | 0.0009 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0067 | 0.0065 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.067 | 0.0661 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0119 | 0.011 |
Brugia malayi | Cytochrome P450 family protein | 0.0044 | 0.0837 | 0.0829 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0021 | 0.0353 | 0.0353 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0026 | 0.0465 | 0.0457 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0026 | 0.0465 | 0.0457 |
Echinococcus multilocularis | Ankyrin | 0.0014 | 0.0226 | 0.0217 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0253 | 0.0244 |
Brugia malayi | 'Paired box' domain containing protein | 0.0005 | 0.0034 | 0.0025 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0026 | 0.0465 | 0.2626 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0021 | 0.0353 | 0.0344 |
Entamoeba histolytica | inositol polyphosphate 5-phosphatase, putative | 0.0004 | 0.0009 | 0.0009 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0253 | 0.0244 |
Schistosoma mansoni | hypothetical protein | 0.0004 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0353 | 0.0344 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0026 | 0.0465 | 0.0457 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0026 | 0.0465 | 0.2626 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0034 | 0.0025 |
Schistosoma mansoni | paired box protein pax-6 | 0.0005 | 0.0034 | 0.0034 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0014 | 0.0224 | 0.0215 |
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0004 | 0.0009 | 0.0007 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0333 | 0.0325 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 0.1094 | 0.1086 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0026 | 0.0465 | 0.0457 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0056 | 0.1094 | 0.1086 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0583 | 0.0583 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0021 | 0.0353 | 0.0344 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0547 | 0.0547 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0067 | 0.0065 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0488 | 1 | 1 |
Echinococcus granulosus | paired box gene 3/7 (eyeless, eyegone, twin of eyeless) | 0.0005 | 0.0034 | 0.0025 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0026 | 0.0465 | 0.0457 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0009 | 0.0009 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.1094 | 0.1092 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0253 | 0.0244 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0026 | 0.0465 | 0.0457 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0488 | 1 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0116 | 0.0108 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0488 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0353 | 0.0353 |
Echinococcus multilocularis | RUN | 0.0021 | 0.0353 | 0.0344 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0056 | 0.1094 | 0.1086 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0014 | 0.0224 | 0.0215 |
Echinococcus granulosus | dnaJ subfamily B | 0.0428 | 0.8765 | 0.8764 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0333 | 0.0325 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0026 | 0.0465 | 0.2626 |
Brugia malayi | Gooseberry protein | 0.0005 | 0.0034 | 0.0025 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.0234 | 0.0226 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0253 | 0.0244 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0333 | 0.0325 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.0583 | 0.0574 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0119 | 0.011 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0026 | 0.0465 | 0.2626 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0253 | 0.0244 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0026 | 0.0465 | 0.2626 |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0004 | 0.0009 | 0.0007 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0026 | 0.0465 | 0.2626 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0353 | 0.0344 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0026 | 0.0465 | 0.0457 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0056 | 0.1094 | 0.1086 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0583 | 0.0583 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0.0253 | 0.0244 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.067 | 0.0661 |
Onchocerca volvulus | 0.0271 | 0.5518 | 0.5514 | |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0465 | 0.0457 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0253 | 0.0244 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0333 | 0.0333 |
Echinococcus multilocularis | paired box protein pax 6 | 0.0005 | 0.0034 | 0.0025 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0081 | 0.0072 |
Entamoeba histolytica | sphingomyelinase C precursor, putative | 0.0004 | 0.0009 | 0.0009 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.067 | 0.067 |
Schistosoma mansoni | cript-related | 0.0004 | 0.0009 | 0.0009 |
Schistosoma mansoni | rab6-interacting | 0.0021 | 0.0353 | 0.0353 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0253 | 0.0244 |
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.0465 | 0.0457 |
Brugia malayi | hypothetical protein | 0.0036 | 0.067 | 0.0661 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0009 | 0.0007 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0026 | 0.0465 | 0.0457 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0067 | 0.0065 |
Onchocerca volvulus | 0.003 | 0.0547 | 0.0539 | |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0026 | 0.0465 | 0.0457 |
Schistosoma mansoni | neutral sphingomyelinase | 0.0004 | 0.0009 | 0.0009 |
Brugia malayi | paired box protein | 0.0005 | 0.0034 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0488 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0026 | 0.0465 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0298 | 0.029 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0026 | 0.0465 | 0.2626 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0108 | 0.2148 | 0.2141 |
Leishmania major | cytochrome p450-like protein | 0.0044 | 0.0837 | 0.0829 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0026 | 0.0465 | 0.0457 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0067 | 0.0065 |
Brugia malayi | cytochrome P450 | 0.0026 | 0.0465 | 0.0457 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0333 | 0.0325 |
Echinococcus multilocularis | paired box protein pax 6 | 0.0005 | 0.0034 | 0.0025 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0058 | 0.112 | 0.1112 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0004 | 0.0002 | 0.0000000044889 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.067 | 0.067 |
Entamoeba histolytica | inositol polyphosphate-5-phosphatase, putative | 0.0004 | 0.0009 | 0.0009 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0026 | 0.0465 | 0.2626 |
Loa Loa (eye worm) | doublecortin family protein | 0.0021 | 0.0353 | 0.0344 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0026 | 0.0465 | 0.0457 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.0253 | 0.0253 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0488 | 1 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0488 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0253 | 0.0244 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0014 | 0.0224 | 0.0224 |
Schistosoma mansoni | netrin receptor unc5 | 0.0014 | 0.0224 | 0.0224 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0333 | 0.0325 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.1094 | 0.1094 |
Echinococcus granulosus | geminin | 0.0169 | 0.3425 | 0.3419 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | cytochrome P450 | 0.0026 | 0.0465 | 0.0457 |
Onchocerca volvulus | 0.0005 | 0.0034 | 0.0025 | |
Mycobacterium leprae | putative cytochrome p450 | 0.0026 | 0.0465 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0044 | 0.0837 | 0.0829 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0056 | 0.1094 | 0.1086 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0067 | 0.0065 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0034 | 0.0025 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0488 | 1 | 1 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0081 | 0.0072 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0081 | 0.0072 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0026 | 0.0465 | 0.0457 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0026 | 0.0465 | 0.0457 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0044 | 0.0837 | 0.0829 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0056 | 0.1094 | 0.1086 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 0.1094 | 0.1086 |
Trypanosoma brucei | cytochrome P450, putative | 0.0044 | 0.0837 | 0.0829 |
Brugia malayi | Uncoordinated protein 44 | 0.0014 | 0.0224 | 0.0215 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0488 | 1 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0021 | 0.0353 | 0.0344 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0056 | 0.1094 | 0.1086 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0021 | 0.0353 | 0.0344 |
Echinococcus multilocularis | paired box protein pax 1 | 0.0005 | 0.0034 | 0.0025 |
Brugia malayi | 'Paired box' domain containing protein | 0.0005 | 0.0034 | 0.0025 |
Trypanosoma brucei | protein kinase, putative | 0.0056 | 0.1094 | 0.1086 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0044 | 0.0837 | 0.0829 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0004 | 0.0009 | 0.0007 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0058 | 0.112 | 0.1112 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0057 | 0.1102 | 0.1095 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0488 | 1 | 1 |
Echinococcus granulosus | death domain containing protein | 0.0014 | 0.0224 | 0.0215 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0026 | 0.0465 | 0.0457 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0014 | 0.0226 | 0.0226 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0221 | 0.4488 | 0.4483 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0333 | 0.0325 |
Schistosoma mansoni | synaptojanin | 0.0004 | 0.0009 | 0.0009 |
Schistosoma mansoni | cytochrome P450 | 0.0026 | 0.0465 | 0.0465 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0333 | 0.0331 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0014 | 0.0224 | 0.0215 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0067 | 0.0065 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0465 | 0.0465 |
Echinococcus granulosus | paired box protein pax 6 | 0.0005 | 0.0034 | 0.0025 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.3425 | 0.3425 |
Echinococcus multilocularis | paired box protein pax 6 | 0.0005 | 0.0034 | 0.0025 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0488 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0067 | 0.0065 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0488 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0056 | 0.1094 | 0.1086 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0488 | 1 | 1 |
Schistosoma mansoni | paired box protein pax-6 | 0.0005 | 0.0034 | 0.0034 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0253 | 0.0253 |
Loa Loa (eye worm) | vab-3 | 0.0005 | 0.0034 | 0.0025 |
Schistosoma mansoni | carbon catabolite repressor protein | 0.0004 | 0.0009 | 0.0009 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0026 | 0.0465 | 0.0457 |
Schistosoma mansoni | synaptojanin | 0.0004 | 0.0009 | 0.0009 |
Plasmodium falciparum | carbon catabolite repressor protein 4, putative | 0.0004 | 0.0009 | 0.0009 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0026 | 0.0465 | 0.0457 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0488 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0067 | 0.0065 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0067 | 0.0065 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0488 | 1 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0021 | 0.0353 | 0.0344 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0056 | 0.1094 | 0.1086 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0488 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0108 | 0.2148 | 0.2141 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0547 | 0.0539 |
Brugia malayi | Death domain containing protein | 0.0014 | 0.0224 | 0.0215 |
Schistosoma mansoni | rab6-interacting | 0.0021 | 0.0353 | 0.0353 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0221 | 0.4488 | 0.4483 |
Echinococcus multilocularis | geminin | 0.0169 | 0.3425 | 0.3419 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0428 | 0.8765 | 0.8764 |
Plasmodium vivax | RNA helicase-1, putative | 0.0488 | 1 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0056 | 0.1094 | 0.1086 |
Onchocerca volvulus | 0.0021 | 0.0353 | 0.0344 | |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0547 | 0.0539 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0067 | 0.0065 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.067 | 0.067 |
Schistosoma mansoni | paired box protein pax-6 | 0.0005 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0271 | 0.5518 | 0.5514 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0021 | 0.0353 | 0.0344 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0067 | 0.0065 |
Plasmodium falciparum | carbon catabolite repressor protein 4, putative | 0.0004 | 0.0009 | 0.0009 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0067 | 0.0065 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0119 | 0.011 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.0253 | 0.0244 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0253 | 0.0244 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0067 | 0.0065 |
Onchocerca volvulus | 0.0005 | 0.0034 | 0.0025 | |
Schistosoma mansoni | paired box protein pax-1-related | 0.0005 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | paired box protein | 0.0005 | 0.0034 | 0.0025 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0026 | 0.0465 | 0.0457 |
Echinococcus multilocularis | 0.0026 | 0.0465 | 0.0457 | |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0333 | 0.0331 |
Echinococcus granulosus | Ankyrin | 0.0014 | 0.0226 | 0.0217 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0016 | 0.0016 |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0004 | 0.0009 | 0.0007 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0004 | 0.0009 | 0.0009 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | 0 % | Percent reduction of edema in rat on 23rd day after oral administration of 30 mg/kg in antiarthritis assay; i = Inactive | ChEMBL. | 6606043 |
Reduction (functional) | = 16.5 % | Percent reduction of edema in mice 3h after oral administration of 30 mg/kg in carrageenin model | ChEMBL. | 6606043 |
Reduction (functional) | = 16.5 % | Percent reduction of edema in mice 3h after oral administration of 30 mg/kg in carrageenin model | ChEMBL. | 6606043 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.