Detailed information for compound 694188

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 329.301 | Formula: C17H13F2N3O2
  • H donors: 1 H acceptors: 2 LogP: 1.66 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccn2c(c1)nc(c(c2=O)NC(=O)c1ccc(c(c1)F)F)C
  • InChi: 1S/C17H13F2N3O2/c1-9-5-6-22-14(7-9)20-10(2)15(17(22)24)21-16(23)11-3-4-12(18)13(19)8-11/h3-8H,1-2H3,(H,21,23)
  • InChiKey: WHGZCTBSGBRFFT-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei importin beta-1 subunit, putative 0.0016 0.0009 0.0021
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0021 0.0024 0.0046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0058 0.013 0.0128
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0051 0.0049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0009 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0009 0.0007
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.0665 0.1548
Onchocerca volvulus 0.0015 0.0004 0.0022
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0426 0.0991
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0009 0.0049
Brugia malayi hypothetical protein 0.0517 0.1471 0.3423
Loa Loa (eye worm) hypothetical protein 0.0084 0.0207 0.0482
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0105 0.0102
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0016 0.0038
Brugia malayi MH1 domain containing protein 0.0016 0.0008 0.0019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0068 0.0159
Loa Loa (eye worm) MBCTL1 0.0056 0.0124 0.0289
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0009 0.0005
Loa Loa (eye worm) GMP reductase 0.0656 0.1878 0.4368
Loa Loa (eye worm) hypothetical protein 0.0056 0.0127 0.0294
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0065 0.0575
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0008 0.0019
Mycobacterium tuberculosis Conserved protein 0.0039 0.0074 0.0155
Brugia malayi MH2 domain containing protein 0.0016 0.0008 0.0019
Onchocerca volvulus 0.0105 0.027 0.1436
Echinococcus granulosus sentrin specific protease 8 0.0039 0.0076 0.0073
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0024 0.0055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0228 0.0224
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0074 0.0661
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0021 0.0024 1
Plasmodium falciparum glutathione reductase 0.0046 0.0095 0.0204
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.0006
Brugia malayi intermediate filament protein 0.0037 0.007 0.0164
Onchocerca volvulus 0.0076 0.0182 0.0971
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0008 0.0071
Trichomonas vaginalis set domain proteins, putative 0.0115 0.0298 0.2655
Onchocerca volvulus 0.0049 0.0105 0.0557
Mycobacterium ulcerans beta-lactamase 0.0039 0.0074 0.0155
Brugia malayi follicle stimulating hormone receptor 0.0241 0.0665 0.1548
Loa Loa (eye worm) hypothetical protein 0.0517 0.1471 0.3423
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0022
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0105 0.0101
Loa Loa (eye worm) hypothetical protein 0.0097 0.0245 0.057
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0018 0.0014 0.0012
Echinococcus multilocularis Smad4 0.0016 0.0008 0.0004
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0105 0.0102
Trichomonas vaginalis inositol monophosphatase, putative 0.0069 0.0162 0.144
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.001 0.0024
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.0644 0.1499
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0009 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0022
Mycobacterium tuberculosis Probable reductase 0.0105 0.0267 0.0604
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0016 0.0012
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0065 0.0575
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0105 0.0234
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0127 0.0122
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0009 0.0005
Schistosoma mansoni hypothetical protein 0.0105 0.027 0.0266
Onchocerca volvulus 0.0115 0.0298 0.1589
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0009 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0008 0.0019
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0039 0.0076 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0009 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0169 0.0165
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0069 0.0162 0.144
Brugia malayi Importin beta-1 subunit 0.0016 0.0009 0.0021
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0016 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0143 0.0139
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0074 0.0118
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0143 0.0314
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0009 0.0007
Leishmania major DNA polymerase eta, putative 0.0019 0.0016 0.0038
Echinococcus granulosus snurportin 1 0.0173 0.0466 0.0464
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0169 0.0165
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.1485 0.4298 1
Schistosoma mansoni coup transcription factor 0.0016 0.0009 0.0005
Brugia malayi Thioredoxin reductase 0.0046 0.0095 0.0222
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0037 0.007 0.0164
Echinococcus granulosus neuropeptide s receptor 0.0627 0.1793 0.1791
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0016 0.0145
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.0006
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.1485 0.4298 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0009 0.0022
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0173 0.0466 0.1085
Loa Loa (eye worm) hypothetical protein 0.0039 0.0074 0.0173
Entamoeba histolytica hypothetical protein 0.0058 0.013 0.1159
Onchocerca volvulus 0.0092 0.023 0.1226
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.001 0.0005
Schistosoma mansoni hypothetical protein 0.0391 0.1103 0.1099
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.027 0.0627
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0228 0.053
Brugia malayi mbt repeat family protein 0.0049 0.0105 0.0243
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0008 0.0071
Echinococcus granulosus tumor protein p63 0.0386 0.1088 0.1086
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0009 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0245 0.057
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.1485 0.4298 1
Schistosoma mansoni survival motor neuron protein 0.0105 0.027 0.0266
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0095 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0065 0.015
Schistosoma mansoni alpha-glucosidase 0.0137 0.0361 0.0357
Toxoplasma gondii thioredoxin reductase 0.0046 0.0095 0.0213
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0074 0.0661
Schistosoma mansoni lamin 0.0037 0.007 0.0066
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0169 0.0393
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0009 0.0007
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0008 0.0009
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0016 0.0019
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0301 0.0683
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0065 0.0575
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0069 0.0162 0.0359
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0074 0.0072
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0124 0.0289
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.0008
Trypanosoma cruzi GMP reductase 0.1485 0.4298 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0105 0.0101
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0301 0.0683
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0267 0.0604
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0061 0.0141 0.031
Schistosoma mansoni Smad4 0.0016 0.0008 0.0004
Schistosoma mansoni importin beta-1 0.0016 0.0009 0.0005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0228 0.053
Schistosoma mansoni hypothetical protein 0.0029 0.0045 0.0041
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0009 0.0005
Brugia malayi MH1 domain containing protein 0.0016 0.0008 0.0019
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0095 0.0222
Brugia malayi hypothetical protein 0.0032 0.0054 0.0125
Brugia malayi Pre-SET motif family protein 0.0015 0.0004 0.0009
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.0644 0.1499
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0087 0.0217 0.0214
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0008 0.0004
Toxoplasma gondii HEAT repeat-containing protein 0.0016 0.0009 0.0011
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0009 0.0005
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0076 0.0672
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.1485 0.4298 0.4297
Echinococcus granulosus importin subunit beta 1 0.0016 0.0009 0.0006
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0074 0.0173
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0069 0.0162 0.0367
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.053 0.0527
Brugia malayi nuclear receptor NHR-88 0.0016 0.0009 0.0022
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0009 0.0022
Entamoeba histolytica hypothetical protein 0.0058 0.013 0.1159
Schistosoma mansoni inositol monophosphatase 0.0069 0.0162 0.0158
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0228 0.0225
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0065 0.0575
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0074 0.007
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.053 0.0528
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0009 0.0022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0008 0.0019
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0016 0.0038
Brugia malayi beta-lactamase 0.0039 0.0074 0.0173
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1485 0.4298 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0009 0.0022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0008 0.0019
Loa Loa (eye worm) hypothetical protein 0.0049 0.0105 0.0243
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.0682 0.157
Loa Loa (eye worm) hypothetical protein 0.0076 0.0182 0.0424
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0095 0.0222
Echinococcus granulosus Smad4 0.0016 0.0008 0.0006
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0074 0.0155
Loa Loa (eye worm) hypothetical protein 0.0029 0.0045 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0009 0.0022
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0008 0.0004
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0021 0.0024 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.001 0.0014
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0101 0.0258 0.0599
Schistosoma mansoni alpha-glucosidase 0.0137 0.0361 0.0357
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0656 0.1878 0.4368
Brugia malayi MH2 domain containing protein 0.0234 0.0644 0.1499
Loa Loa (eye worm) hypothetical protein 0.0037 0.007 0.0164
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0008 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0016 0.0038
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0009 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0105 0.0243
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0829 0.2382 0.5518
Brugia malayi TAR-binding protein 0.0071 0.0169 0.0393
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0656 0.1878 0.4368
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0076 0.0672
Giardia lamblia DINP protein human, muc B family 0.0019 0.0016 1
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0169 0.0165
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0105 0.0243
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0143 0.0323
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0016 0.0145
Loa Loa (eye worm) hypothetical protein 0.0056 0.0124 0.0289
Echinococcus multilocularis snurportin 1 0.0173 0.0466 0.0462
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0009 0.0005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0267 0.0604
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0008 0.0019
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0065 0.0575
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0065 0.0062
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0267 0.0604
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0074 0.0155
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.001 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0009 0.0022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0058 0.013 0.0126
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.001 0.0024
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0143 0.0314
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0065 0.0575
Onchocerca volvulus 0.0016 0.0009 0.0049
Leishmania major hypothetical protein, conserved 0.0039 0.0074 0.0173
Trypanosoma brucei importin beta-1 subunit, putative 0.0016 0.0009 0.0021
Echinococcus granulosus neuropeptide receptor A26 0.0627 0.1793 0.1791
Leishmania major inosine-5-monophosphate dehydrogenase 0.1485 0.4298 1
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0169 0.0165
Brugia malayi RNA, U transporter 1 0.0046 0.0096 0.0224
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0105 0.0557
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0009 0.0049
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.1485 0.4298 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0018 0.0014 0.001
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0074 0.0155
Schistosoma mansoni inositol monophosphatase 0.0069 0.0162 0.0158
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0008 0.0019
Trypanosoma cruzi GMP reductase 0.1485 0.4298 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0009 0.0022
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0065 0.015
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0076 0.0182 0.0178
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0124 0.012
Echinococcus multilocularis neuropeptide receptor A26 0.0627 0.1793 0.179
Mycobacterium ulcerans lipase LipD 0.0039 0.0074 0.0155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0009 0.0005
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0065 0.015
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1485 0.4298 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1245 0.3598 0.3596
Loa Loa (eye worm) hypothetical protein 0.0019 0.0016 0.0038
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0016 0.0038
Schistosoma mansoni hypothetical protein 0.0299 0.0836 0.0832
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Schistosoma mansoni lamin 0.0037 0.007 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0021 0.0024 0.0046
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.001 0.0006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0069 0.0162 0.0377
Schistosoma mansoni hypothetical protein 0.0022 0.0026 0.0022
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0074 0.007
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0069 0.0162 0.0377
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0267 0.0604
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0016 0.0019
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0105 0.0225
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0008 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0074 0.0164
Echinococcus granulosus L aminoadipate semialdehyde 0.0076 0.0182 0.018
Brugia malayi Smad1 0.0016 0.0008 0.0019
Leishmania major hypothetical protein, conserved 0.0049 0.0105 0.0243
Echinococcus granulosus dna polymerase eta 0.0019 0.0016 0.0014
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0009 0.0005
Brugia malayi Isocitrate dehydrogenase 0.0017 0.001 0.0024
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.001 0.0014
Brugia malayi ecdysteroid receptor 0.0016 0.0009 0.0022
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0124 0.0122
Leishmania major hypothetical protein, conserved 0.0029 0.0045 0.0105
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.1485 0.4298 0.4296
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0267 0.0604
Brugia malayi hypothetical protein 0.0084 0.0207 0.0482
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0016 0.0012
Schistosoma mansoni intermediate filament proteins 0.0037 0.007 0.0066
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0087 0.0217 0.0213
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0301 0.0683
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0105 0.0101
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0398 0.1124 1
Brugia malayi Inositol-1 0.0069 0.0162 0.0377
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0065 0.015
Onchocerca volvulus 0.0037 0.007 0.0375
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0008 0.0019
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0105 0.0234
Brugia malayi beta-lactamase family protein 0.0039 0.0074 0.0173
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0008 0.0019
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0105 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0009 0.0022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0008 0.0019
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0065 0.0575
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0009 0.0007
Brugia malayi nuclear hormone receptor 0.0016 0.0009 0.0022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0074 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0021 0.0024 0.0037
Loa Loa (eye worm) IMP dehydrogenase 1 0.1485 0.4298 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0051 0.0119
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0009 0.0007
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0016 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0228 0.0224
Brugia malayi glutathione reductase 0.0046 0.0095 0.0222
Plasmodium falciparum thioredoxin reductase 0.0046 0.0095 0.0204
Loa Loa (eye worm) hypothetical protein 0.0039 0.0074 0.0173
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0008 0.0019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0143 0.0314
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0245 0.057
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.1485 0.4298 1
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0656 0.1878 0.4337
Schistosoma mansoni smad1 5 8 and 0.0016 0.0008 0.0004
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0087 0.0217 0.0504
Brugia malayi isocitrate dehydrogenase 0.0017 0.001 0.0024
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0009 0.0005
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0021 0.0024 0.0037
Loa Loa (eye worm) hypothetical protein 0.0039 0.0074 0.0173
Brugia malayi RNA binding protein 0.0071 0.0169 0.0393
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0169 0.0393
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0095 0.0204
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0038
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0074 0.0155
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0022
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0009 0.0005
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0026 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0074 0.0173
Trypanosoma brucei trypanothione reductase 0.0046 0.0095 0.0222
Loa Loa (eye worm) intermediate filament protein 0.0037 0.007 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0009 0.0022
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0426 0.0423
Brugia malayi Kringle domain containing protein 0.0029 0.0045 0.0105
Echinococcus multilocularis importin subunit beta 1 0.0016 0.0009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0022
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0016 0.0038
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0169 0.0393
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0228 0.0224
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0426 0.0422
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0301 0.0649
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0398 0.1124 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0228 0.0225
Echinococcus multilocularis survival motor neuron protein 1 0.0517 0.1471 0.1468
Echinococcus multilocularis sentrin specific protease 8 0.0039 0.0076 0.0071
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0105 0.0243
Loa Loa (eye worm) RNA binding protein 0.0071 0.0169 0.0393
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0009 0.0007
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0069 0.0162 0.144
Trypanosoma brucei GMP reductase 0.1485 0.4298 1
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0095 0.0213
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0656 0.1878 0.4358
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0051 0.0119
Echinococcus granulosus smad 0.0016 0.0008 0.0006
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0076 0.0672
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0022
Schistosoma mansoni transcription factor LCR-F1 0.0058 0.013 0.0126
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.001 0.0024
Echinococcus multilocularis microtubule associated protein 2 0.3437 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0095 0.0093
Echinococcus multilocularis GPCR, family 2 0.0031 0.0051 0.0047
Schistosoma mansoni microtubule-associated protein tau 0.3437 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0037 0.007 0.0164
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0009 0.0022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0051 0.0049
Onchocerca volvulus 0.0039 0.0074 0.0396
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0069 0.0162 0.0377
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0009 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Echinococcus granulosus inositol monophosphatase 1 0.0069 0.0162 0.0159
Loa Loa (eye worm) beta-lactamase 0.0039 0.0074 0.0173
Onchocerca volvulus Huntingtin homolog 0.0084 0.0207 0.1104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0009 0.0022
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0074 0.0155
Echinococcus multilocularis lamin dm0 0.0037 0.007 0.0066
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0008 0.0019
Loa Loa (eye worm) hypothetical protein 0.0066 0.0155 0.0361
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0008 0.0019
Echinococcus multilocularis neuropeptide s receptor 0.0627 0.1793 0.179
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0074 0.0173
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0008 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0074 0.0661
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0029 0.0045 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0009 0.0022
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0009 0.0022
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0074 0.0155
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0124 0.0122
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0061 0.0141 0.0274
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0009 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0074 0.007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0022
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.1485 0.4298 1
Entamoeba histolytica hypothetical protein 0.0058 0.013 0.1159
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0087 0.0217 0.0504
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0039 0.0076 0.0176
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0074 0.0173
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0087 0.0217 0.0213
Loa Loa (eye worm) glutathione reductase 0.0046 0.0095 0.0222
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.001 0.0024
Echinococcus granulosus lamin 0.0037 0.007 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0009 0.0022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.002 0.002 0.0046
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0426 0.0991
Brugia malayi cytoplasmic intermediate filament protein 0.002 0.002 0.0046
Mycobacterium tuberculosis Conserved protein 0.0039 0.0074 0.0155
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0074 0.0661
Schistosoma mansoni smad 0.0016 0.0008 0.0004
Loa Loa (eye worm) Ulp1 protease 0.0039 0.0076 0.0176
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0016 0.0038
Plasmodium vivax importin-beta 2, putative 0.0016 0.0009 0.0011
Schistosoma mansoni DNA polymerase eta 0.0019 0.0016 0.0012
Echinococcus multilocularis tumor protein p63 0.0386 0.1088 0.1085
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0009 0.0022
Trypanosoma brucei unspecified product 0.0019 0.0016 0.0038
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0069 0.0162 0.144
Onchocerca volvulus Putative GMP reductase 0.0656 0.1878 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0008 0.0019
Schistosoma mansoni hypothetical protein 0.0031 0.0051 0.0047
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.001 0.0014
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0267 0.0569
Leishmania major DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Schistosoma mansoni alpha glucosidase 0.0035 0.0065 0.0061
Echinococcus multilocularis musashi 0.0037 0.007 0.0066
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0021 0.0024 0.0046
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1485 0.4298 1
Echinococcus granulosus lamin dm0 0.0037 0.007 0.0068
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0076 0.0182 0.0424
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0051 0.0119
Loa Loa (eye worm) inositol-1 0.0069 0.0162 0.0377
Schistosoma mansoni hypothetical protein 0.0173 0.0466 0.0462
Echinococcus granulosus dna polymerase kappa 0.0019 0.0016 0.0014
Echinococcus granulosus tar DNA binding protein 0.0071 0.0169 0.0167
Toxoplasma gondii IMP dehydrogenas 0.1485 0.4298 1
Trichomonas vaginalis Sentrin-specific protease, putative 0.0039 0.0076 0.0672
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.1485 0.4298 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0016 0.0019
Schistosoma mansoni smad1 5 8 and 0.0016 0.0008 0.0004
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0065 0.0575
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0051 0.0047
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0143 0.0314
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0074 0.0661
Onchocerca volvulus 0.0029 0.0045 0.024
Brugia malayi hypothetical protein 0.0049 0.0105 0.0243
Schistosoma mansoni hypothetical protein 0.0031 0.0051 0.0047
Brugia malayi hypothetical protein 0.0058 0.013 0.0303
Onchocerca volvulus 0.0056 0.0127 0.0674
Plasmodium vivax glutathione reductase, putative 0.0046 0.0095 0.0213
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.1485 0.4298 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0008 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0065 0.0575
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0143 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0009 0.0022
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0105 0.0101
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0105 0.0101
Mycobacterium ulcerans hypothetical protein 0.0039 0.0074 0.0155
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0051 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0021
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0009 0.0005
Entamoeba histolytica hypothetical protein 0.0058 0.013 0.1159
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0074 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0045 0.0105
Loa Loa (eye worm) Smad1 0.0016 0.0008 0.0019
Entamoeba histolytica hypothetical protein 0.0021 0.0024 0.0211
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0065 0.0575
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0008 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0009 0.0022
Brugia malayi beta-lactamase family protein 0.0039 0.0074 0.0173
Schistosoma mansoni hypothetical protein 0.0031 0.0051 0.0047
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0016 0.0145
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0009
Brugia malayi Protein kinase domain containing protein 0.0029 0.0045 0.0105
Toxoplasma gondii ABC1 family protein 0.0039 0.0074 0.0164
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0008 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0228 0.0224
Leishmania major phosphopantetheinyl transferase-like protein 0.0021 0.0024 0.0055
Brugia malayi MH2 domain containing protein 0.0016 0.0008 0.0019
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0009 0.0005
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0065 0.0575
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0008 0.0019
Echinococcus multilocularis smad 0.0016 0.0008 0.0004
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.001 0.0006
Toxoplasma gondii kringle domain-containing protein 0.0029 0.0045 0.0095
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0008 0.0006
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0008 0.0019
Schistosoma mansoni hypothetical protein 0.0391 0.1103 0.1099
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0008 0.0006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0245 0.057
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0074 0.0155
Loa Loa (eye worm) hypothetical protein 0.0031 0.0051 0.0119
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0008 0.0006
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0124 0.012
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0155 0.0361
Echinococcus multilocularis L aminoadipate semialdehyde 0.0076 0.0182 0.0178
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0087 0.0217 0.0213
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0009 0.0007
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0009 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0009 0.0022
Onchocerca volvulus 0.0037 0.007 0.0375
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0143 0.0139
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0026 0.0022
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0008 0.0009
Echinococcus multilocularis tissue type plasminogen activator 0.0029 0.0045 0.0041
Brugia malayi mbt repeat family protein 0.0049 0.0105 0.0243
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0069 0.0162 0.0359
Mycobacterium leprae Probable lipase LipE 0.0039 0.0074 0.0118
Trichomonas vaginalis esterase, putative 0.0039 0.0074 0.0661
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0022
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.1485 0.4298 0.4296
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.001 0.0024
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.001 0.0006
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0009 0.0022
Echinococcus granulosus intermediate filament protein 0.0037 0.007 0.0068
Echinococcus multilocularis geminin 0.0391 0.1103 0.1099
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0829 0.2382 0.5534
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0228 0.0224
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0087 0.0217 0.0214
Loa Loa (eye worm) hypothetical protein 0.0039 0.0074 0.0173
Trypanosoma cruzi hypothetical protein 0.0039 0.0076 0.0176
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0169 0.0165
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0009 0.0005
Brugia malayi Pre-SET motif family protein 0.0101 0.0258 0.0599
Leishmania major guanosine monophosphate reductase 0.1485 0.4298 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0207 0.0482
Echinococcus granulosus histone lysine methyltransferase setb 0.0015 0.0004 0.0002
Echinococcus granulosus survival motor neuron protein 1 0.0517 0.1471 0.1469
Plasmodium falciparum cysteine repeat modular protein 1 0.0029 0.0045 0.0086
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.1485 0.4298 1
Trypanosoma brucei glucosidase, putative 0.0035 0.0065 0.015
Leishmania major trypanothione reductase 0.0046 0.0095 0.0222
Echinococcus multilocularis dna polymerase eta 0.0019 0.0016 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0009 0.0005
Echinococcus multilocularis inositol monophosphatase 1 0.0069 0.0162 0.0158
Schistosoma mansoni hypothetical protein 0.0031 0.0051 0.0047
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0021 0.0024 0.0037
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0038
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0008 0.0019
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0021 0.0024 0.0037
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0426 0.0422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0009 0.0022
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0065 0.0141
Schistosoma mansoni hypothetical protein 0.0066 0.0155 0.0151
Schistosoma mansoni hypothetical protein 0.0058 0.013 0.0126
Brugia malayi steroid hormone receptor 0.0016 0.0009 0.0022
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0143 0.0332
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0008 0.0019
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0124 0.012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0009 0.0022
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0016 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0016 0.0038
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0105 0.0243
Loa Loa (eye worm) hypothetical protein 0.0039 0.0074 0.0173
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.0006
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0008 0.0004
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0065 0.0061
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0009 0.0049
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0069 0.0162 0.0377
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0169 0.0165
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0039 0.0076 0.0672
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0009 0.0005
Onchocerca volvulus Huntingtin homolog 0.0084 0.0207 0.1104
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0009 0.0005
Echinococcus granulosus geminin 0.0391 0.1103 0.1101
Onchocerca volvulus 0.0039 0.0074 0.0396
Echinococcus multilocularis lamin 0.0037 0.007 0.0066
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0016 0.0014
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0074 0.0155
Plasmodium falciparum importin beta, putative 0.0016 0.0009 0.0002
Onchocerca volvulus 0.0039 0.0074 0.0396
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0065 0.015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0074 0.0173
Loa Loa (eye worm) hypothetical protein 0.0049 0.0105 0.0243
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0016 0.0038
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0008 0.0009
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0021 0.0024 0.0037
Mycobacterium tuberculosis Conserved protein 0.0039 0.0074 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0009 0.0022
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0028
Brugia malayi GMP reductase 0.0656 0.1878 0.4368
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0028
Echinococcus granulosus tissue type plasminogen activator 0.0029 0.0045 0.0043
Echinococcus granulosus GPCR family 2 0.0031 0.0051 0.0049
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.001 0.0024
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0143 0.014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0022
Loa Loa (eye worm) TK/ROR protein kinase 0.0029 0.0045 0.0105

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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