Detailed information for compound 718587

Basic information

Technical information
  • TDR Targets ID: 718587
  • Name: 3-(1,3-benzodioxol-5-yl)-1-[4-(ethylsulfamoyl )phenyl]urea
  • MW: 363.388 | Formula: C16H17N3O5S
  • H donors: 3 H acceptors: 3 LogP: 1.63 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNS(=O)(=O)c1ccc(cc1)NC(=O)Nc1ccc2c(c1)OCO2
  • InChi: 1S/C16H17N3O5S/c1-2-17-25(21,22)13-6-3-11(4-7-13)18-16(20)19-12-5-8-14-15(9-12)24-10-23-14/h3-9,17H,2,10H2,1H3,(H2,18,19,20)
  • InChiKey: QMEDCVHXKLSJFO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • IVK/1184892
  • ZINC02852904

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0057 0.0974
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0057 0.0046
Entamoeba histolytica hypothetical protein 0.0035 0.0234 0.2156
Onchocerca volvulus Huntingtin homolog 0.0124 0.1342 0.4583
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0319 0.0522
Brugia malayi PHD-finger family protein 0.0029 0.0155 0.0254
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0064 0.059 0.0592
Schistosoma mansoni hypothetical protein 0.0162 0.1801 0.1808
Schistosoma mansoni hypothetical protein 0.004 0.0301 0.0302
Loa Loa (eye worm) hypothetical protein 0.0051 0.0436 0.0712
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0064 0.059 0.1384
Echinococcus granulosus cpg binding protein 0.0063 0.0579 0.0582
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1527 0.1533
Treponema pallidum DNA ligase (lig) 0.0019 0.0039 0.5
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.1009 0.1009
Schistosoma mansoni cpg binding protein 0.0063 0.0579 0.0582
Loa Loa (eye worm) hypothetical protein 0.0124 0.1342 0.2192
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0339 1
Brugia malayi RNA binding protein 0.0062 0.0568 0.0928
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.018 0.0181
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0606 0.0989
Schistosoma mansoni lamin 0.0027 0.014 0.0141
Brugia malayi CXXC zinc finger family protein 0.0058 0.0515 0.0841
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.018 0.0181
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0001 0.0002
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0016 0.0016
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0515 0.0841
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0606 0.0608
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0039 0.0554
Brugia malayi hypothetical protein 0.0016 0.0001 0.0002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.018 0.0181
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0162 0.1801 0.1801
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0057 0.0094
Echinococcus multilocularis GPCR, family 2 0.0162 0.1801 0.1801
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0674 0.6607
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0606 0.0608
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.007 0.0674 0.1595
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0057 0.0974
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0057 0.0486
Leishmania major UDP-galactopyranose mutase 0.0064 0.059 0.8753
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0162 0.1801 0.2942
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.1183 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.014 0.0141
Brugia malayi DKFZp564C0469 protein 0.0019 0.0039 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.018 0.0294
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0064
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0057 0.0046
Echinococcus granulosus geminin 0.0504 0.6037 0.606
Loa Loa (eye worm) hypothetical protein 0.0039 0.0284 0.0464
Mycobacterium ulcerans hypothetical protein 0.0043 0.0339 0.0755
Brugia malayi AMP-binding enzyme family protein 0.007 0.0674 0.1101
Trypanosoma cruzi UDP-galactopyranose mutase 0.0064 0.059 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.018 0.0181
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0568 0.0571
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0057 0.0974
Loa Loa (eye worm) hypothetical protein 0.007 0.0674 0.1101
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.018 0.018
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0057 0.0365
Echinococcus granulosus FTZ F1 alpha 0.0031 0.018 0.0181
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0057 0.0094
Echinococcus granulosus GPCR family 2 0.0162 0.1801 0.1808
Schistosoma mansoni chromosome transmission fidelity factor 0.0019 0.0039 0.0039
Schistosoma mansoni DNA ligase IV 0.0019 0.0039 0.0039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0511 0.6122 1
Echinococcus multilocularis lamin dm0 0.0027 0.014 0.014
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.018 0.0294
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0339 0.1048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0031 0.0031
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0057 0.0291
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0339 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.2663 0.435
Loa Loa (eye worm) hypothetical protein 0.0043 0.0339 0.0554
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.0294
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.007 0.0674 0.1595
Brugia malayi SWIRM domain containing protein 0.0018 0.0021 0.0035
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0057 0.0046
Loa Loa (eye worm) hypothetical protein 0.0098 0.1009 0.1648
Loa Loa (eye worm) hypothetical protein 0.0064 0.059 0.0963
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.018 0.0181
Schistosoma mansoni patched 1 0.0042 0.0319 0.0321
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0339 0.0341
Schistosoma mansoni zinc finger protein 0.0023 0.0088 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0319 0.9371
Loa Loa (eye worm) hypothetical protein 0.015 0.1654 0.2703
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.0294
Schistosoma mansoni hypothetical protein 0.004 0.0301 0.0302
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0019 0.0039 0.033
Leishmania major hypothetical protein, conserved 0.0043 0.0339 0.5038
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0001 0.0001
Loa Loa (eye worm) beta-lactamase 0.0043 0.0339 0.0554
Plasmodium vivax replication factor C subunit 1, putative 0.0019 0.0039 0.0661
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.0294
Echinococcus multilocularis zinc finger protein 0.0023 0.0088 0.0088
Onchocerca volvulus 0.0027 0.014 0.0357
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0341 0.4019 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.018 0.0181
Plasmodium falciparum protoporphyrinogen oxidase 0.0064 0.059 1
Brugia malayi hypothetical protein 0.0064 0.059 0.0963
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0057 0.0094
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0057 0.0046
Echinococcus granulosus zinc finger protein 0.0023 0.0088 0.0089
Brugia malayi beta-lactamase family protein 0.0043 0.0339 0.0554
Mycobacterium tuberculosis Conserved protein 0.0043 0.0339 0.1048
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0339 0.1048
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0341 0.4019 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0057 0.0046
Echinococcus multilocularis tumor protein p63 0.0343 0.4051 0.4051
Schistosoma mansoni amine oxidase 0.0064 0.059 0.0592
Schistosoma mansoni topbp1 0.0019 0.0039 0.0039
Echinococcus multilocularis protein patched 0.0042 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0042 0.0319 0.0522
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.0294
Brugia malayi ecdysteroid receptor 0.0031 0.018 0.0294
Brugia malayi Bromodomain containing protein 0.0079 0.0785 0.1283
Mycobacterium tuberculosis Conserved protein 0.0043 0.0339 0.1048
Brugia malayi jmjC domain containing protein 0.0065 0.0606 0.0989
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0339 0.4733
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.0294
Schistosoma mansoni hypothetical protein 0.0021 0.0061 0.0061
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.1027 0.1031
Brugia malayi TAR-binding protein 0.0062 0.0568 0.0928
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.018 0.0294
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0057 0.0177
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0039 0.0554
Trypanosoma cruzi UDP-galactopyranose mutase 0.0064 0.059 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0063 0.0063
Brugia malayi beta-lactamase family protein 0.0043 0.0339 0.0554
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.018 0.018
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0339 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0031 0.0031
Echinococcus granulosus lamin 0.0027 0.014 0.0141
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0016 0.0016
Echinococcus multilocularis dnaJ subfamily B 0.0821 0.9962 0.9962
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.018 0.0294
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0339 1
Echinococcus granulosus tar DNA binding protein 0.0062 0.0568 0.0571
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.018 0.018
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0339 1
Onchocerca volvulus 0.0058 0.0515 0.1673
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0674 0.6607
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0039 0.0554
Schistosoma mansoni hypothetical protein 0.0504 0.6037 0.606
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0067 0.0633 0.5354
Loa Loa (eye worm) intermediate filament protein 0.0027 0.014 0.0229
Brugia malayi nuclear receptor RXR 0.0016 0.0001 0.0002
Echinococcus granulosus expressed conserved protein 0.0092 0.0935 0.0939
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.018 0.0181
Loa Loa (eye worm) RNA binding protein 0.0062 0.0568 0.0928
Onchocerca volvulus 0.0043 0.0339 0.1057
Entamoeba histolytica acyl-coA synthetase, putative 0.007 0.0674 0.6607
Plasmodium vivax hypothetical protein, conserved 0.0064 0.059 1
Schistosoma mansoni hypothetical protein 0.0162 0.1801 0.1808
Echinococcus granulosus tumor protein p63 0.0343 0.4051 0.4067
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0039 0.0554
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0057 0.0094
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0061 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0039 0.0554
Echinococcus multilocularis lamin 0.0027 0.014 0.014
Loa Loa (eye worm) oxidoreductase 0.0021 0.0057 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0039 0.0661
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0057 0.0974
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0418 0.1289
Mycobacterium ulcerans dehydrogenase 0.0064 0.059 0.1384
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0453 0.1041
Brugia malayi Latrophilin receptor protein 2 0.0162 0.1801 0.2942
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0057 0.0974
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0057 0.0177
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0674 1
Onchocerca volvulus 0.0031 0.018 0.0495
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0568 0.0571
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0022 0.0022
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0541 0.0543
Loa Loa (eye worm) hypothetical protein 0.0231 0.2663 0.435
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0057 0.0291
Echinococcus granulosus intermediate filament protein 0.0027 0.014 0.0141
Toxoplasma gondii histone lysine-specific demethylase 0.0064 0.059 0.4986
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0001 0.0002
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0339 0.1048
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0339 0.1048
Entamoeba histolytica hypothetical protein 0.0035 0.0234 0.2156
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0057 0.0177
Loa Loa (eye worm) hypothetical protein 0.0053 0.0453 0.074
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0231 0.2663 0.2673
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0253 0.0254
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0231 0.2663 0.2663
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0277 0.323 0.9972
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0057 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0568 0.0571
Loa Loa (eye worm) hypothetical protein 0.0043 0.0339 0.0554
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0022 0.0067
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0541 0.0541
Schistosoma mansoni thyroid hormone receptor 0.0031 0.018 0.0181
Loa Loa (eye worm) hypothetical protein 0.0064 0.059 0.0963
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0568 0.0571
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0002
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0057 0.0291
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.018 0.0181
Schistosoma mansoni hypothetical protein 0.004 0.0301 0.0302
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0019 0.0039 0.5
Onchocerca volvulus 0.0027 0.014 0.0357
Schistosoma mansoni bromodomain containing protein 0.0068 0.0638 0.064
Loa Loa (eye worm) hypothetical protein 0.007 0.0674 0.1101
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0057 0.0486
Mycobacterium ulcerans lipase LipD 0.0043 0.0339 0.0755
Entamoeba histolytica hypothetical protein 0.0035 0.0234 0.2156
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0057 0.0057
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0057 0.0046
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0057 0.0177
Onchocerca volvulus 0.0021 0.0057 0.0065
Echinococcus multilocularis 0.0064 0.059 0.059
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.014 0.0229
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0057 0.0094
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.018 0.018
Echinococcus granulosus lysine specific histone demethylase 1A 0.0064 0.059 0.0592
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.018 0.0294
Loa Loa (eye worm) hypothetical protein 0.0124 0.1342 0.2192
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.018 0.0495
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0057 0.0058
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.007 0.0674 0.1595
Onchocerca volvulus 0.005 0.0423 0.1352
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.0294
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.018 0.0294
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0057 0.0094
Mycobacterium tuberculosis Conserved protein 0.0043 0.0339 0.1048
Schistosoma mansoni topbp1 0.0019 0.0039 0.0039
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0453 0.7521
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.018 0.0181
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0568 0.0928
Brugia malayi hypothetical protein 0.0124 0.1342 0.2192
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0674 0.1595
Mycobacterium ulcerans hypothetical protein 0.007 0.0674 0.1595
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.007 0.0674 0.208
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.018 0.0294
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0018 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0418 0.1289
Onchocerca volvulus 0.0249 0.2883 1
Onchocerca volvulus 0.007 0.0674 0.2232
Brugia malayi hypothetical protein 0.0019 0.0039 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0568 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.018 0.0294
Mycobacterium ulcerans oxidoreductase 0.0064 0.059 0.1384
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0057 0.0853
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0234 0.0235
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0057 0.1134
Echinococcus granulosus replication factor c subunit 1 0.0019 0.0039 0.0039
Brugia malayi AMP-binding enzyme family protein 0.007 0.0674 0.1101
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0541 0.0541
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.1315 0.132
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.018 0.0294
Echinococcus multilocularis musashi 0.0027 0.014 0.014
Schistosoma mansoni SWI/SNF complex-related 0.0018 0.0021 0.0021
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0253 0.0253
Brugia malayi hypothetical protein 0.0035 0.0234 0.0383
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0064 0.059 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0016 0.0016
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.0294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.018 0.0294
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.018 0.018
Onchocerca volvulus 0.0021 0.0057 0.0065
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0674 0.1595
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0162 0.1801 0.2942
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0339 0.0755
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0019 0.0039 0.0179
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0039 0.1149
Loa Loa (eye worm) hypothetical protein 0.0053 0.0453 0.074
Echinococcus granulosus dnaJ subfamily B 0.0821 0.9962 1
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0339 0.0755
Loa Loa (eye worm) hypothetical protein 0.0041 0.0314 0.0512
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.018 0.0294
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0568 0.0928
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.1009 0.1648
Loa Loa (eye worm) hypothetical protein 0.0043 0.0339 0.0554
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0057 0.0046
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0057 0.0486
Onchocerca volvulus 0.0043 0.0339 0.1057
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0339 0.0341
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0019 0.0039 0.0064
Echinococcus multilocularis replication factor c subunit 1 0.0019 0.0039 0.0039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.018 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0039 0.0554
Loa Loa (eye worm) hypothetical protein 0.0072 0.0691 0.1128
Brugia malayi Bromodomain containing protein 0.0039 0.0283 0.0462
Mycobacterium leprae Probable lipase LipE 0.0043 0.0339 0.4733
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0001 0.0002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0022 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0418 0.1289
Loa Loa (eye worm) hypothetical protein 0.0043 0.0339 0.0554
Toxoplasma gondii SWIRM domain-containing protein 0.0018 0.0021 0.0181
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0674 0.1595
Loa Loa (eye worm) hypothetical protein 0.007 0.0674 0.1101
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.018 0.0294
Plasmodium falciparum replication factor C subunit 1, putative 0.0019 0.0039 0.0661
Onchocerca volvulus 0.0021 0.0057 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.018 0.0294
Brugia malayi hypothetical protein 0.015 0.1654 0.2703
Loa Loa (eye worm) hypothetical protein 0.0081 0.081 0.1323
Brugia malayi latrophilin 2 splice variant baaae 0.0349 0.4122 0.6733
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0162 0.1801 0.1808
Loa Loa (eye worm) hypothetical protein 0.0043 0.0339 0.0554
Schistosoma mansoni nuclear hormone receptor 0.0031 0.018 0.0181
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0339 0.5756
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1527 0.1527
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.018 0.0294
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0125 0.0126
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.018 0.018
Echinococcus multilocularis cpg binding protein 0.0063 0.0579 0.0579
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.018 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.018 0.0294
Trichomonas vaginalis esterase, putative 0.0043 0.0339 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.018 0.0294
Schistosoma mansoni amine oxidase 0.0064 0.059 0.0592
Echinococcus granulosus nibrin 0.0019 0.0039 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0057 0.0046
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0319 0.0321
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.018 0.0181
Brugia malayi CHE-14 protein 0.0042 0.0319 0.0522
Loa Loa (eye worm) hypothetical protein 0.005 0.0423 0.0692
Echinococcus multilocularis expressed conserved protein 0.0092 0.0935 0.0935
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.018 0.0294
Schistosoma mansoni hypothetical protein 0.0349 0.4122 0.4138
Mycobacterium ulcerans monoamine oxidase 0.0064 0.059 0.1384
Schistosoma mansoni cpg binding protein 0.0058 0.0515 0.0517
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0606 0.0608
Mycobacterium tuberculosis Possible oxidoreductase 0.0064 0.059 0.182
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0423 0.0425
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0057 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.018 0.0294
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.018 0.0495
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.0094
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0057 0.1692
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.1009 0.1013
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0039 0.0554
Brugia malayi hypothetical protein 0.0019 0.0039 0.0064
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0319 0.0319
Brugia malayi amine oxidase, flavin-containing family protein 0.0081 0.081 0.1323
Brugia malayi AMP-binding enzyme family protein 0.007 0.0674 0.1101
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0039 0.0554
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0234 0.0234
Echinococcus multilocularis protein dispatched 1 0.0048 0.0393 0.0393
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0031 0.0031
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0057 0.0058
Entamoeba histolytica hypothetical protein 0.0019 0.0039 0.0179
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0039 0.0661
Loa Loa (eye worm) hypothetical protein 0.0053 0.0453 0.074
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0593 0.0593
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0064 0.059 1
Schistosoma mansoni hypothetical protein 0.0162 0.1801 0.1808
Toxoplasma gondii ATPase, AAA family protein 0.0019 0.0039 0.033
Mycobacterium ulcerans beta-lactamase 0.0043 0.0339 0.0755
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0018 0.0021 0.0021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0674 1
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0057 0.0853
Giardia lamblia Replication factor C, subunit 1 0.0019 0.0039 1
Entamoeba histolytica hypothetical protein 0.0035 0.0234 0.2156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0002
Echinococcus multilocularis nibrin 0.0019 0.0039 0.0039
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0339 0.1048
Brugia malayi topoisomerase 0.0019 0.0039 0.0064
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.018 0.018
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.018 0.0294
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.018 0.0294
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0022 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0064 0.059 1
Schistosoma mansoni jumonji domain containing protein 0.006 0.0541 0.0543
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0057 0.0046
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0339 0.0341
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0234 0.0235
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0057 0.0046
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0057 0.1692
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0057 0.0046
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.0094
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0039 0.0661
Schistosoma mansoni hypothetical protein 0.004 0.0301 0.0302
Trypanosoma cruzi FHA domain containing protein, putative 0.0019 0.0039 0.0661
Loa Loa (eye worm) hypothetical protein 0.0053 0.0453 0.074
Loa Loa (eye worm) hypothetical protein 0.0027 0.0134 0.0219
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3239 1
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0023 0.0038
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.059 0.182
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0339 0.1048
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0339 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.018 0.0181
Schistosoma mansoni hypothetical protein 0.0035 0.0234 0.0235
Onchocerca volvulus 0.0021 0.0057 0.0065
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0057 0.0177
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0125 0.0126
Loa Loa (eye worm) hypothetical protein 0.0053 0.0453 0.074
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0339 0.5756
Chlamydia trachomatis protoporphyrinogen oxidase 0.0064 0.059 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.0294
Schistosoma mansoni hypothetical protein 0.0162 0.1801 0.1808
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0453 0.7685
Loa Loa (eye worm) hypothetical protein 0.0349 0.4122 0.6733
Brugia malayi SWIRM domain containing protein 0.0249 0.2883 0.4709
Brugia malayi nuclear hormone receptor 0.0031 0.018 0.0294
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0064
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0057 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.018 0.0294
Toxoplasma gondii ABC1 family protein 0.0043 0.0339 0.287
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.018 0.0294
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0064 0.059 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0057 0.0046
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.018 0.0181
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0057 0.0046
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0339 0.0554
Loa Loa (eye worm) latrophilin receptor protein 2 0.0162 0.1801 0.2942
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0064 0.059 1
Schistosoma mansoni lamin 0.0027 0.014 0.0141
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0162 0.1801 0.1808
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0593 0.0595
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0125 0.0125
Echinococcus multilocularis geminin 0.0504 0.6037 0.6037
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.018 0.0495
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0057 0.0177
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0674 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0057 0.0046
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0063 0.0063
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0043 0.0071
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0162 0.1801 0.1801
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0453 0.1399
Loa Loa (eye worm) hypothetical protein 0.0043 0.0339 0.0554
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0339 0.5756
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.018 0.018
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0057 0.0853
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0453 0.7685
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.018 0.0181
Onchocerca volvulus 0.015 0.1654 0.5681
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0001 0.0001
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0039 0.0554
Echinococcus multilocularis protoporphyrinogen oxidase 0.0064 0.059 0.059
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.018 0.0181
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0057 0.0177
Echinococcus granulosus lysine specific histone demethylase 1A 0.0231 0.2663 0.2673
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0504 0.6037 0.606
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0319 0.0321
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0674 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.018 0.0294
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0057 0.0046
Schistosoma mansoni thyroid hormone receptor 0.0031 0.018 0.0181
Brugia malayi hypothetical protein 0.0016 0.0001 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0511 0.6122 1
Schistosoma mansoni coup transcription factor 0.0031 0.018 0.0181
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.018 0.0181
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0511 0.6122 1
Brugia malayi intermediate filament protein 0.0027 0.014 0.0229
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0057 0.0177
Brugia malayi beta-lactamase 0.0043 0.0339 0.0554
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0057 0.1134
Brugia malayi jmjC domain containing protein 0.006 0.0541 0.0884
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0057 0.0177
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0064
Onchocerca volvulus Huntingtin homolog 0.0124 0.1342 0.4583
Echinococcus granulosus lamin dm0 0.0027 0.014 0.0141
Brugia malayi nuclear receptor NHR-88 0.0031 0.018 0.0294
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0339 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.018 0.0294
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0031 0.0031
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.1009 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.014 0.0229
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0001 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0001 0.0001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0339 0.0339
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0057 0.0177
Loa Loa (eye worm) hypothetical protein 0.0047 0.0378 0.0618
Trichomonas vaginalis replication factor C large subunit, putative 0.0019 0.0039 0.0554
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.018 0.0181
Onchocerca volvulus 0.0043 0.0339 0.1057
Loa Loa (eye worm) hypothetical protein 0.0027 0.014 0.0229
Loa Loa (eye worm) hypothetical protein 0.0511 0.6122 1
Loa Loa (eye worm) hypothetical protein 0.0249 0.2883 0.4709
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0418 0.1289
Brugia malayi Pax transcription activation domain interacting protein 0.0019 0.0039 0.0064
Schistosoma mansoni hypothetical protein 0.0821 0.9962 1
Schistosoma mansoni cpg binding protein 0.0063 0.0579 0.0582
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0674 0.208
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0057 0.0974
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0051
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0568 0.0928
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0674 0.1595
Brugia malayi steroid hormone receptor 0.0031 0.018 0.0294
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0674 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0057 0.0094
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0339 0.1048
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0064 0.059 0.8677

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 42.765 uM PubChem BioAssay. Counterscreen for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors: Luminescence-based cell-based high throughput dose response assay to identify agonists of OPRM1 homodimerization. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) > 92.489 uM PUBCHEM_BIOASSAY: Counterscreen for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors: Luminescence-based cell-based high throughput dose response assay to identify agonists of OPRD1 homodimerization. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905] ChEMBL. No reference
EC50 (functional) > 92.489 uM PUBCHEM_BIOASSAY: Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504326, AID504355, AID504692, AID504904, AID504905] ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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