Detailed information for compound 719932

Basic information

Technical information
  • TDR Targets ID: 719932
  • Name: 5-(3-hydroxy-3-methylbut-1-ynyl)-N-[2-(4-meth oxyphenyl)ethyl]thiophene-2-carboxamide
  • MW: 343.44 | Formula: C19H21NO3S
  • H donors: 2 H acceptors: 2 LogP: 3.27 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CCNC(=O)c1ccc(s1)C#CC(O)(C)C
  • InChi: 1S/C19H21NO3S/c1-19(2,22)12-10-16-8-9-17(24-16)18(21)20-13-11-14-4-6-15(23-3)7-5-14/h4-9,22H,11,13H2,1-3H3,(H,20,21)
  • InChiKey: QNSDNKSTJJSCKC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(3-hydroxy-3-methyl-but-1-ynyl)-N-[2-(4-methoxyphenyl)ethyl]thiophene-2-carboxamide
  • 5-(3-hydroxy-3-methylbut-1-ynyl)-N-[2-(4-methoxyphenyl)ethyl]-2-thiophenecarboxamide
  • A3362/0142725
  • ZINC00610261

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0024 0.0329
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0059 0.012 0.1361
Giardia lamblia Cathepsin L precursor 0.0059 0.012 0.1118
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0731 0.83
Leishmania major pyruvate kinase 0.0035 0.0034 0.0388
Entamoeba histolytica hypothetical protein 0.0059 0.012 0.164
Echinococcus multilocularis rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Echinococcus granulosus neuropeptide Y receptor 0.0208 0.0664 0.0869
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0115 0.0148
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0227 0.0731 0.0731
Entamoeba histolytica calpain large subunit domain III containing protein 0.006 0.0125 0.1715
Brugia malayi Cathepsin L-like precursor 0.0227 0.0731 0.0731
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0086 0.022 0.0852
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0229 0.0739 0.0969
Onchocerca volvulus 0.0208 0.0664 0.9077
Trypanosoma brucei antigen, putative 0.0086 0.022 0.2496
Echinococcus granulosus pyruvate kinase 0.0035 0.0034 0.0042
Giardia lamblia Cathepsin L precursor 0.0059 0.012 0.1118
Onchocerca volvulus 0.0037 0.004 0.0517
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0239 0.0777 0.1019
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0002 0.0002
Echinococcus granulosus fmrfamide receptor 0.0208 0.0664 0.0869
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Entamoeba histolytica cysteine protease, putative 0.0127 0.0368 0.5029
Loa Loa (eye worm) hypothetical protein 0.0051 0.0093 0.0093
Echinococcus multilocularis serotonin receptor 0.0208 0.0664 0.0869
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0208 0.0664 0.0871
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0159 0.0484 0.1873
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.007 0.016 0.016
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0046 0.0522
Leishmania major cathepsin L-like protease 0.0227 0.0731 0.83
Entamoeba histolytica cysteine proteinase, putative 0.0227 0.0731 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0208 0.0664 0.0869
Onchocerca volvulus 0.0227 0.0731 1
Brugia malayi Dopamine receptor protein 1 0.0208 0.0664 0.0664
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0208 0.0664 0.9077
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.004 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0368 0.4174
Trypanosoma cruzi cruzipain precursor, putative 0.0227 0.0731 0.2833
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.004 0.004
Brugia malayi hypothetical protein 0.0033 0.0026 0.0026
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0049 0.019
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.0345 0.1335
Trypanosoma cruzi cysteine peptidase, putative 0.0227 0.0731 0.2833
Brugia malayi Cathepsin L-like precursor 0.0068 0.0153 0.0153
Entamoeba histolytica cysteine protease, putative 0.0059 0.012 0.164
Loa Loa (eye worm) matrixin family protein 0.0092 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.004 0.0172
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.0345 0.0345
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0208 0.0664 0.0869
Loa Loa (eye worm) calpain family protein 1 0.0229 0.0739 0.0739
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0227 0.0731 0.83
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0059 0.012 0.1361
Echinococcus granulosus dro:myosuppressin receptor 0.0208 0.0664 0.0869
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.06 0.0785
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0136 0.0178
Entamoeba histolytica cysteine protease, putative 0.0127 0.0368 0.5029
Echinococcus granulosus rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0059 0.012 0.0157
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0024 0.0273
Brugia malayi neuropeptide F receptor 0.0208 0.0664 0.0664
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0345 0.3911
Brugia malayi GnHR receptor homolog 0.0208 0.0664 0.0664
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0049 0.0557
Brugia malayi 6-phosphofructokinase 0.012 0.0345 0.0345
Toxoplasma gondii ABC1 family protein 0.0037 0.004 0.0449
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0049 0.0478
Entamoeba histolytica cysteine protease, putative 0.0127 0.0368 0.5029
Mycobacterium leprae PROBABLE HYDROLASE 0.0046 0.0074 0.1287
Brugia malayi putative neuropeptide receptor NPR1 0.0208 0.0664 0.0664
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0089 0.0117
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0127 0.0368 0.0482
Schistosoma mansoni amine GPCR 0.0208 0.0664 0.0871
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Brugia malayi Melibiase family protein 0.007 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0168 0.0519 0.0519
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0115 0.0148
Onchocerca volvulus Cathepsin L homolog 0.0227 0.0731 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0208 0.0664 0.0871
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.012 0.1361
Echinococcus granulosus sex peptide receptor 0.0208 0.0664 0.0869
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0046 0.0058
Loa Loa (eye worm) inositol-1 0.0039 0.0049 0.0049
Entamoeba histolytica cysteine proteinase, putative 0.0127 0.0368 0.5029
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.004 0.0449
Brugia malayi Matrixin family protein 0.0038 0.0044 0.0044
Plasmodium falciparum serine repeat antigen 5 0.0059 0.012 0.164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.06 0.0785
Loa Loa (eye worm) hypothetical protein 0.0038 0.0044 0.0044
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0059 0.012 0.164
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0731 0.83
Loa Loa (eye worm) RNA binding protein 0.0063 0.0136 0.0136
Brugia malayi Cathepsin L-like precursor 0.0227 0.0731 0.0731
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0136 0.0136
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0049 0.0557
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.004 0.0076
Loa Loa (eye worm) hypothetical protein 0.0037 0.004 0.004
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.0644 0.0843
Brugia malayi Cathepsin L-like cysteine proteinase 0.0159 0.0484 0.0484
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0731 0.83
Plasmodium vivax calpain, putative 0.0086 0.022 0.277
Brugia malayi calpain 7 0.0086 0.022 0.022
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0227 0.0731 0.0731
Echinococcus granulosus rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Echinococcus granulosus cathepsin l1 0.0159 0.0484 0.0632
Plasmodium vivax vivapain-1 0.0127 0.0368 0.486
Brugia malayi beta-lactamase family protein 0.0037 0.004 0.004
Echinococcus multilocularis fibrillin 1 0.006 0.0123 0.0159
Echinococcus granulosus neuropeptide Y receptor 0.0208 0.0664 0.0869
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0034 0.0034
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0208 0.0664 0.0871
Onchocerca volvulus 0.0208 0.0664 0.9077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.012 0.1361
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0093 0.1268
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Echinococcus multilocularis cathepsin L 0.0059 0.012 0.0155
Brugia malayi Cathepsin L-like precursor 0.0227 0.0731 0.0731
Echinococcus multilocularis serotonin receptor 0.0208 0.0664 0.0869
Echinococcus granulosus cathepsin L cysteine proteinase 0.0227 0.0731 0.0957
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0046 0.0522
Leishmania major kinesin, putative 0.006 0.0125 0.1423
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0099 0.0099
Schistosoma mansoni cathepsin F (C01 family) 0.0227 0.0731 0.0959
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0059 0.012 0.1361
Brugia malayi phosphofructokinase 0.012 0.0345 0.0345
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0045 0.0057
Giardia lamblia Cathepsin B precursor 0.0059 0.012 0.1118
Entamoeba histolytica cysteine protease, putative 0.0127 0.0368 0.5029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.06 0.0787
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0059 0.012 0.164
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0046 0.0074 0.0549
Onchocerca volvulus 0.0054 0.0102 0.1368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0731 0.83
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0105 0.0287 0.0374
Echinococcus multilocularis neuropeptide s receptor 0.0208 0.0664 0.0869
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0731 0.83
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0227 0.0731 0.0731
Echinococcus multilocularis cathepsin b 0.0734 0.2581 0.3384
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0174 0.0539 0.0539
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0734 0.2581 0.3385
Schistosoma mansoni cathepsin D (A01 family) 0.0147 0.044 0.0577
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0287 0.0376
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Echinococcus multilocularis calpain A 0.0239 0.0777 0.1017
Leishmania major cathepsin L-like protease 0.0227 0.0731 0.83
Echinococcus multilocularis g protein coupled receptor 0.0208 0.0664 0.0869
Schistosoma mansoni 6-phosphofructokinase 0.012 0.0345 0.0452
Onchocerca volvulus 0.0208 0.0664 0.9077
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0208 0.0664 0.0869
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0731 0.83
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0731 0.83
Schistosoma mansoni cathepsin D (A01 family) 0.0147 0.044 0.0577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0731 0.83
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0731 0.83
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0045 0.0059
Echinococcus granulosus rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.005 0.0087 0.0985
Loa Loa (eye worm) AStacin protease 0.0116 0.0328 0.0328
Chlamydia trachomatis pyruvate kinase 0.0035 0.0034 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.004 0.0076
Brugia malayi beta-lactamase 0.0037 0.004 0.004
Echinococcus multilocularis G protein coupled receptor 139 0.0208 0.0664 0.0869
Schistosoma mansoni opsin-like receptor 0.0208 0.0664 0.0871
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0227 0.0731 0.0957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0731 0.83
Leishmania major hypothetical protein, conserved 0.0051 0.0093 0.1052
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0332 0.0332
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0734 0.2581 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.004 0.0049
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0208 0.0664 0.0871
Onchocerca volvulus 0.0227 0.0731 1
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0086 0.022 0.2496
Brugia malayi Serotonin receptor 0.0208 0.0664 0.0664
Onchocerca volvulus 0.0208 0.0664 0.9077
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0086 0.022 0.0852
Loa Loa (eye worm) hypothetical protein 0.0734 0.2581 0.2581
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.0345 0.0345
Brugia malayi hypothetical protein 0.0038 0.0045 0.0045
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0227 0.0731 0.0957
Echinococcus granulosus calpain A 0.0086 0.022 0.0286
Loa Loa (eye worm) hypothetical protein 0.0038 0.0044 0.0044
Giardia lamblia Cathepsin B precursor 0.0268 0.0881 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0287 0.0376
Onchocerca volvulus 0.0208 0.0664 0.9077
Trypanosoma cruzi kinesin, putative 0.006 0.0125 0.0486
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0115 0.0148
Echinococcus multilocularis somatostatin receptor 0.0208 0.0664 0.0869
Entamoeba histolytica protein kinase, putative 0.006 0.0125 0.1715
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.012 0.1361
Brugia malayi Matrixin family protein 0.0092 0.024 0.024
Toxoplasma gondii melibiase subfamily protein 0.0105 0.0287 0.3256
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0059 0.012 0.012
Echinococcus granulosus 7TM GPCR rhodopsin 0.0208 0.0664 0.0869
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0208 0.0664 0.0871
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0024 0.0273
Echinococcus multilocularis cathepsin L cysteine protease 0.0227 0.0731 0.0957
Brugia malayi hypothetical protein 0.0051 0.0093 0.0093
Leishmania major cathepsin L-like protease 0.0227 0.0731 0.83
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0024 0.0329
Brugia malayi hypothetical protein 0.0208 0.0664 0.0664
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.007 0.016 0.1814
Trypanosoma brucei calpain-like protein, putative 0.0086 0.022 0.2496
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0208 0.0664 0.0869
Giardia lamblia Encystation-specific protease 0.0059 0.012 0.1118
Leishmania major cathepsin L-like protease 0.0227 0.0731 0.83
Brugia malayi Papain family cysteine protease containing protein 0.0127 0.0368 0.0368
Entamoeba histolytica cysteine protease, putative 0.0127 0.0368 0.5029
Loa Loa (eye worm) hypothetical protein 0.0037 0.004 0.004
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0034 0.0034
Brugia malayi Papain family cysteine protease containing protein 0.0127 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0068 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Echinococcus granulosus cathepsin l1 0.0227 0.0731 0.0957
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0208 0.0664 0.0869
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0208 0.0664 0.0869
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.005 0.0087 0.0111
Loa Loa (eye worm) hypothetical protein 0.0159 0.0484 0.0484
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0034 0.0443
Brugia malayi cathepsin B-like cysteine proteinase 0.0734 0.2581 0.2581
Echinococcus granulosus pyruvate kinase 0.0035 0.0034 0.0042
Echinococcus multilocularis allatostatin A receptor 0.0208 0.0664 0.0869
Giardia lamblia Cathepsin L-like protease 0.0059 0.012 0.1118
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Plasmodium vivax serine-repeat antigen (SERA) 0.0059 0.012 0.1355
Schistosoma mansoni amine GPCR 0.0208 0.0664 0.0871
Schistosoma mansoni opsin-like receptor 0.0208 0.0664 0.0871
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0086 0.022 0.2496
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0059 0.012 0.012
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0086 0.022 0.0852
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.012 0.012
Echinococcus granulosus cathepsin l cysteine peptidase 0.0227 0.0731 0.0957
Loa Loa (eye worm) aspartic protease BmAsp-2 0.005 0.0087 0.0087
Entamoeba histolytica cysteine proteinase, putative 0.0227 0.0731 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0049 0.0064
Echinococcus granulosus rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0034 0.0132
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0049 0.0557
Loa Loa (eye worm) hypothetical protein 0.0038 0.0044 0.0044
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0227 0.0731 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0087 0.0087
Echinococcus granulosus biogenic amine 5HT receptor 0.0208 0.0664 0.0869
Onchocerca volvulus 0.0037 0.004 0.0517
Mycobacterium ulcerans beta-lactamase 0.0037 0.004 0.0172
Giardia lamblia Cathepsin L precursor 0.0059 0.012 0.1118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.06 0.06
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0268 0.0881 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0227 0.0731 1
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.012 0.1361
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.004 0.0153
Entamoeba histolytica cysteine proteinase, putative 0.0127 0.0368 0.5029
Echinococcus granulosus allatostatin A receptor 0.0208 0.0664 0.0869
Mycobacterium tuberculosis Conserved protein 0.0037 0.004 0.0076
Giardia lamblia Cysteine protease 0.0059 0.012 0.1118
Mycobacterium leprae conserved hypothetical protein 0.0037 0.004 0.0179
Echinococcus multilocularis g-protein coupled receptor 0.0208 0.0664 0.0869
Echinococcus multilocularis pyruvate kinase 0.0035 0.0034 0.0042
Echinococcus granulosus lysosomal alpha glucosidase 0.0174 0.0539 0.0704
Loa Loa (eye worm) hypothetical protein 0.0203 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0037 0.004 0.004
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0239 0.0777 0.1017
Mycobacterium tuberculosis Conserved protein 0.0037 0.004 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0731 0.83
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.012 0.0157
Entamoeba histolytica cysteine protease, putative 0.0059 0.012 0.164
Loa Loa (eye worm) hypothetical protein 0.005 0.0089 0.0089
Echinococcus granulosus calpain A 0.0239 0.0777 0.1017
Plasmodium vivax vivapain-2 0.0227 0.0731 1
Onchocerca volvulus 0.0159 0.0484 0.6602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0368 0.4174
Brugia malayi Glycosyl hydrolases family 31 protein 0.0174 0.0539 0.0539
Brugia malayi cathepsin L-like cysteine proteinase 0.0059 0.012 0.012
Brugia malayi Inositol-1 0.0039 0.0049 0.0049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.004 0.0052
Echinococcus multilocularis cysteine protease 0.0227 0.0731 0.0957
Plasmodium vivax plasmepsin IV, putative 0.005 0.0087 0.0887
Loa Loa (eye worm) G-protein coupled receptor 0.0208 0.0664 0.0664
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.004 0.0449
Echinococcus granulosus neuropeptide receptor A26 0.0208 0.0664 0.0869
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0227 0.0731 0.83
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0049 0.0557
Echinococcus multilocularis rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0227 0.0731 0.83
Loa Loa (eye worm) hypothetical protein 0.006 0.0123 0.0123
Entamoeba histolytica cysteine protease, putative 0.0059 0.012 0.164
Loa Loa (eye worm) hypothetical protein 0.0057 0.0115 0.0115
Trypanosoma cruzi cysteine proteinase, putative 0.0127 0.0368 0.1425
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.012 0.012
Entamoeba histolytica cysteine protease, putative 0.0127 0.0368 0.5029
Giardia lamblia Pyruvate kinase 0.0035 0.0034 0.0118
Schistosoma mansoni biogenic amine receptor 0.0208 0.0664 0.0871
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.0345 0.045
Onchocerca volvulus 0.0208 0.0664 0.9077
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0208 0.0664 0.0871
Brugia malayi hypothetical protein 0.0208 0.0664 0.0664
Echinococcus granulosus microtubule associated protein 2 0.2118 0.7626 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0086 0.022 0.0852
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.016 0.021
Giardia lamblia Cysteine protease 0.0059 0.012 0.1118
Schistosoma mansoni cathepsin B (C01 family) 0.0059 0.012 0.0157
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0049 0.0557
Onchocerca volvulus 0.0038 0.0044 0.0575
Entamoeba histolytica cysteine proteinase, putative 0.0159 0.0484 0.6611
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0208 0.0664 0.0871
Echinococcus multilocularis rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Plasmodium falciparum cysteine proteinase falcipain 1 0.0127 0.0368 0.5029
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0268 0.0881 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0208 0.0664 0.0871
Leishmania major cathepsin L-like protease 0.0227 0.0731 0.83
Giardia lamblia Cysteine protease 0.0059 0.012 0.1118
Brugia malayi calpain family protein 1 0.0229 0.0739 0.0739
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Echinococcus multilocularis G-protein coupled receptor, putative 0.0208 0.0664 0.0869
Onchocerca volvulus 0.0227 0.0731 1
Echinococcus granulosus cathepsin b 0.0734 0.2581 0.3384
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0089 0.0115
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.004 0.0076
Schistosoma mansoni biogenic amine (5HT) receptor 0.0208 0.0664 0.0871
Entamoeba histolytica cysteine protease, putative 0.0127 0.0368 0.5029
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0059 0.012 0.1355
Toxoplasma gondii cathepsin B 0.0268 0.0881 1
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0024 0.0273
Loa Loa (eye worm) fibroinase 0.0227 0.0731 0.0731
Mycobacterium leprae Probable lipase LipE 0.0037 0.004 0.0179
Echinococcus multilocularis rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.005 0.0087 0.0111
Plasmodium falciparum plasmepsin I 0.005 0.0087 0.1187
Onchocerca volvulus 0.0142 0.0425 0.5797
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0034 0.0443
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0093 0.1268
Trypanosoma cruzi cysteine protease, putative 0.0127 0.0368 0.1425
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0229 0.0739 0.0739
Trypanosoma brucei calpain-like protein, putative 0.0086 0.022 0.2496
Echinococcus granulosus calpain 7 C02 family 0.0086 0.022 0.0286
Echinococcus granulosus serotonin receptor 0.0208 0.0664 0.0869
Echinococcus granulosus alpha 1A adrenergic receptor 0.0208 0.0664 0.0869
Schistosoma mansoni alpha-glucosidase 0.015 0.0451 0.0591
Brugia malayi mbt repeat family protein 0.005 0.0089 0.0089
Echinococcus granulosus neuropeptides capa receptor 0.0208 0.0664 0.0869
Trypanosoma cruzi cysteine peptidase, putative 0.0227 0.0731 0.2833
Entamoeba histolytica cysteine protease, putative 0.0127 0.0368 0.5029
Brugia malayi cathepsin Z-like cysteine proteinase 0.0059 0.012 0.012
Schistosoma mansoni 6-phosphofructokinase 0.012 0.0345 0.0452
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0046 0.0522
Plasmodium vivax vivapain-2 0.0227 0.0731 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0059 0.012 0.1355
Onchocerca volvulus Arrow homolog 0.0054 0.0101 0.1365
Echinococcus granulosus g protein coupled receptor 0.0208 0.0664 0.0869
Brugia malayi Tachykinin-like peptides receptor 99D 0.0208 0.0664 0.0664
Schistosoma mansoni calpain-7 (C02 family) 0.0086 0.022 0.0288
Loa Loa (eye worm) hypothetical protein 0.0159 0.0484 0.0484
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.0345 0.3911
Schistosoma mansoni alpha-glucosidase 0.015 0.0451 0.0591
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0024 0.0273
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0099 0.0099
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0046 0.0058
Schistosoma mansoni egf-like domain protein 0.0054 0.0101 0.0133
Entamoeba histolytica cysteine protease, putative 0.0227 0.0731 1
Leishmania major cathepsin L-like protease 0.0227 0.0731 0.83
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0734 0.2581 0.3385
Brugia malayi neuropeptide F receptor 0.0208 0.0664 0.0664
Onchocerca volvulus 0.005 0.0089 0.12
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0227 0.0731 0.83
Brugia malayi Hemopexin family protein 0.0054 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Echinococcus granulosus g protein coupled receptor 0.0208 0.0664 0.0869
Plasmodium vivax vivapain-3 0.0127 0.0368 0.486
Schistosoma mansoni intermediate filament proteins 0.0026 0.0002 0.0002
Brugia malayi intermediate filament protein 0.0026 0.0002 0.0002
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0059 0.012 0.1355
Loa Loa (eye worm) hypothetical protein 0.0054 0.0101 0.0101
Schistosoma mansoni neuropeptide receptor 0.0208 0.0664 0.0871
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0136 0.0178
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0208 0.0664 0.0871
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0059 0.012 0.0157
Leishmania major pyruvate kinase 0.0035 0.0034 0.0388
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0059 0.012 0.1118
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0034 0.0034
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.005 0.0087 0.0985
Schistosoma mansoni hypothetical protein 0.0173 0.0537 0.0704
Echinococcus granulosus somatostatin receptor 0.0208 0.0664 0.0869
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0034 0.0388
Plasmodium falciparum serine repeat antigen 8 0.0059 0.012 0.164
Echinococcus multilocularis calpain 7 (C02 family) 0.0086 0.022 0.0286
Loa Loa (eye worm) ctsf protein 0.0227 0.0731 0.0731
Brugia malayi Matrixin family protein 0.0038 0.0044 0.0044
Brugia malayi Cathepsin L-like precursor 0.0227 0.0731 0.0731
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0068 0.0153 0.0153
Loa Loa (eye worm) cathepsin B 0.0268 0.0881 0.0881
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0059 0.012 0.1355
Loa Loa (eye worm) hypothetical protein 0.0178 0.0554 0.0554
Schistosoma mansoni hypothetical protein 0.0208 0.0664 0.0871
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0038 0.0044 0.0057
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0138 0.0409 0.0533
Giardia lamblia Cathepsin B precursor 0.0059 0.012 0.1118
Schistosoma mansoni amine GPCR 0.0208 0.0664 0.0871
Echinococcus multilocularis rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Schistosoma mansoni amine GPCR 0.0208 0.0664 0.0871
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0185 0.0581 0.0762
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.06 0.0787
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Schistosoma mansoni neuropeptide F-like receptor 0.0208 0.0664 0.0871
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0024 0.0273
Brugia malayi putative neuropeptide receptor 0.0208 0.0664 0.0664
Plasmodium falciparum serine repeat antigen 2 0.0059 0.012 0.164
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0093 0.0971
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0287 0.0376
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0054 0.0101 0.0101
Schistosoma mansoni growth hormone secretagogue receptor 0.0208 0.0664 0.0871
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.012
Echinococcus multilocularis microtubule associated protein 2 0.2118 0.7626 1
Leishmania major cathepsin L-like protease 0.0227 0.0731 0.83
Echinococcus granulosus Tolloid protein 1 0.0185 0.0581 0.076
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0105 0.0287 0.0374
Loa Loa (eye worm) hypothetical protein 0.0054 0.0101 0.0101
Onchocerca volvulus 0.0208 0.0664 0.9077
Loa Loa (eye worm) neuropeptide F receptor 0.0208 0.0664 0.0664
Onchocerca volvulus 0.0101 0.0272 0.37
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0002 0.0002
Schistosoma mansoni biogenic amine receptor 0.0208 0.0664 0.0871
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0045 0.0057
Loa Loa (eye worm) hypothetical protein 0.0037 0.004 0.004
Onchocerca volvulus Cathepsin L homolog 0.0059 0.012 0.1619
Echinococcus multilocularis pyruvate kinase 0.0035 0.0034 0.0042
Echinococcus granulosus neuropeptide FF receptor 2 0.0208 0.0664 0.0869
Trypanosoma brucei calpain-like protein, putative 0.0086 0.022 0.2496
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.004 0.0449
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.0345 1
Trypanosoma brucei glucosidase, putative 0.0039 0.0046 0.0522
Giardia lamblia Cathepsin L precursor 0.0059 0.012 0.1118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0731 0.83
Echinococcus multilocularis neuropeptides capa receptor 0.0208 0.0664 0.0869
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Brugia malayi G protein-coupled receptor F59B2.13 0.0208 0.0664 0.0664
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0208 0.0664 0.0664
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0089 0.12
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0227 0.0731 0.83
Brugia malayi Cathepsin L-like precursor 0.0159 0.0484 0.0484
Loa Loa (eye worm) calpain family protein 1 0.0168 0.0519 0.0519
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0731 0.83
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.012 0.1361
Echinococcus granulosus biogenic amine 5HT receptor 0.0208 0.0664 0.0869
Echinococcus granulosus orexin receptor type 2 0.0208 0.0664 0.0869
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Entamoeba histolytica cysteine protease, putative 0.0127 0.0368 0.5029
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0046 0.0046
Echinococcus granulosus calpain 0.0086 0.022 0.0286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0227 0.0731 0.83
Trypanosoma cruzi major cysteine proteinase, putative 0.0059 0.012 0.0465
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0731 0.83
Giardia lamblia Cathepsin B precursor 0.0059 0.012 0.1118
Brugia malayi Cathepsin L-like precursor 0.0227 0.0731 0.0731
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0059 0.012 0.1361
Onchocerca volvulus 0.0227 0.0731 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0731 0.83
Giardia lamblia Cathepsin L precursor 0.0059 0.012 0.1118
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0046 0.0178
Echinococcus multilocularis neuropeptide FF receptor 2 0.0208 0.0664 0.0869
Brugia malayi calpain family protein 1 0.0229 0.0739 0.0739
Echinococcus granulosus hypothetical protein 0.0208 0.0664 0.0869
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.062
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Toxoplasma gondii cathepsin CPL 0.0227 0.0731 0.83
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.0345 0.4266
Brugia malayi hypothetical protein 0.0208 0.0664 0.0664
Schistosoma mansoni lamin 0.0026 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Schistosoma mansoni calpain-7 (C02 family) 0.0086 0.022 0.0288
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0093 0.1052
Loa Loa (eye worm) neuropeptide F receptor 0.0208 0.0664 0.0664
Echinococcus multilocularis g protein coupled receptor 0.0208 0.0664 0.0869
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0086 0.022 0.0852
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0208 0.0664 0.0871
Loa Loa (eye worm) hypothetical protein 0.0076 0.0181 0.0181
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0049 0.0062
Mycobacterium ulcerans hydrolase 0.0046 0.0074 0.1281
Onchocerca volvulus 0.0227 0.0731 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.06 0.06
Echinococcus granulosus cathepsin L 0.0127 0.0368 0.048
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.004 0.0449
Schistosoma mansoni hypothetical protein 0.0036 0.0038 0.005
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0046 0.0046
Brugia malayi Fibulin-1 precursor 0.006 0.0123 0.0123
Onchocerca volvulus 0.0227 0.0731 1
Brugia malayi hypothetical protein 0.0131 0.0382 0.0382
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0332 0.0332
Echinococcus granulosus cathepsin b 0.0734 0.2581 0.3384
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0239 0.0777 0.1017
Trypanosoma cruzi cysteine peptidase, putative 0.0127 0.0368 0.1425
Entamoeba histolytica cysteine protease, putative 0.0059 0.012 0.164
Onchocerca volvulus Cathepsin F homolog 0.0227 0.0731 1
Echinococcus multilocularis cysteine protease 0.0227 0.0731 0.0957
Echinococcus multilocularis calpain family protein 1, d 0.0168 0.0519 0.0679
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.012 0.1361
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0208 0.0664 0.0869
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0208 0.0664 0.0664
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0059 0.012 0.1355
Onchocerca volvulus 0.0208 0.0664 0.9077
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Plasmodium vivax unspecified product 0.0068 0.0153 0.1827
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0059 0.012 0.1355
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0208 0.0664 0.0869
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0208 0.0664 0.0869
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0208 0.0664 0.0871
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0731 0.83
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.004 0.0449
Echinococcus multilocularis orexin receptor type 2 0.0208 0.0664 0.0869
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.012 0.1361
Echinococcus granulosus G protein coupled receptor 139 0.0208 0.0664 0.0869
Loa Loa (eye worm) matrix metalloproteinase 0.0038 0.0044 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0208 0.0664 0.0871
Schistosoma mansoni biogenic amine (5HT) receptor 0.0208 0.0664 0.0871
Onchocerca volvulus 0.0208 0.0664 0.9077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.004 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.06 0.0787
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0345 0.4712
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0059 0.012 0.1118
Toxoplasma gondii cathepsin CPC1 0.0059 0.012 0.1361
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.004 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Loa Loa (eye worm) hypothetical protein 0.0037 0.004 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.012 0.1361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.0484 0.5487
Plasmodium falciparum serine repeat antigen 9 0.0059 0.012 0.164
Onchocerca volvulus 0.0208 0.0664 0.9077
Schistosoma mansoni calpain C (C02 family) 0.0086 0.022 0.0288
Brugia malayi sulfakinin receptor protein 0.2769 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0208 0.0664 0.0871
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Echinococcus granulosus tar DNA binding protein 0.0063 0.0136 0.0175
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.0345 1
Loa Loa (eye worm) hypothetical protein 0.2769 1 1
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0034 0.0034
Trypanosoma brucei kinesin, putative 0.006 0.0125 0.1423
Trichomonas vaginalis esterase, putative 0.0037 0.004 0.0449
Echinococcus multilocularis rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0208 0.0664 0.0869
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0034 0.0388
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0046 0.0178
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0046 0.0522
Schistosoma mansoni pyruvate kinase 0.0035 0.0034 0.0045
Brugia malayi hypothetical protein 0.0208 0.0664 0.0664
Plasmodium vivax unspecified product 0.0127 0.0368 0.486
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0034 0.0388
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0046 0.0522
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0268 0.0881 0.1156
Onchocerca volvulus Cathepsin L homolog 0.0227 0.0731 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.0345 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0059 0.012 0.1355
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.012 0.0157
Schistosoma mansoni inositol monophosphatase 0.0039 0.0049 0.0064
Brugia malayi calpain 5 0.006 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.012
Toxoplasma gondii preprocathepsin c precursor, putative 0.0059 0.012 0.1361
Schistosoma mansoni hypothetical protein 0.0311 0.1038 0.1361
Loa Loa (eye worm) hypothetical protein 0.0068 0.0153 0.0153
Schistosoma mansoni opsin-like receptor 0.0208 0.0664 0.0871
Schistosoma mansoni hypothetical protein 0.0038 0.0045 0.0059
Echinococcus granulosus neuropeptide s receptor 0.0208 0.0664 0.0869
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0208 0.0664 0.0871
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0227 0.0731 0.83
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.062
Echinococcus multilocularis neuropeptide receptor 0.0208 0.0664 0.0869
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0034 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Loa Loa (eye worm) hypothetical protein 0.0142 0.0425 0.0425
Loa Loa (eye worm) melatonin receptor type 1A 0.0208 0.0664 0.0664
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0105 0.0287 0.0374
Brugia malayi G-protein coupled receptor 0.0208 0.0664 0.0664
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.004 0.0449
Echinococcus multilocularis neuropeptide receptor 0.0208 0.0664 0.0869
Schistosoma mansoni lamin 0.0026 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0227 0.0731 0.83
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0093 0.0359
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0208 0.0664 0.0869
Echinococcus granulosus g protein coupled receptor 0.0208 0.0664 0.0869
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0127 0.0368 0.4174
Loa Loa (eye worm) hypothetical protein 0.0035 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0086 0.022 0.0852
Giardia lamblia Cathepsin B precursor 0.0268 0.0881 1
Plasmodium falciparum pyruvate kinase 0.0035 0.0034 0.0468
Schistosoma mansoni pyruvate kinase 0.0035 0.0034 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0208 0.0664 0.0871
Brugia malayi Matrixin family protein 0.0038 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0287 0.0376
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.0762 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0115 0.0115
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0093 0.0359
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.004 0.0172
Entamoeba histolytica cysteine proteinase 1, putative 0.0127 0.0368 0.5029
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0046 0.0522
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0208 0.0664 0.0871
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0034 0.0143
Echinococcus multilocularis g protein coupled receptor 0.0208 0.0664 0.0869
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.016 0.021
Onchocerca volvulus 0.0208 0.0664 0.9077
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0208 0.0664 0.0664
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0227 0.0731 0.83
Giardia lamblia Hypothetical protein 0.0059 0.012 0.1118
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0024 0.0273
Entamoeba histolytica cysteine protease, putative 0.0059 0.012 0.164
Echinococcus granulosus cysteine protease 0.0127 0.0368 0.048
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0345 0.3911
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0086 0.022 0.0852
Schistosoma mansoni biogenic amine receptor 0.0208 0.0664 0.0871
Schistosoma mansoni alpha-1 adrenergic receptor 0.0208 0.0664 0.0871
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0026 0.0000078507 0.0000078507
Echinococcus multilocularis laminin 0.006 0.0123 0.0159
Echinococcus granulosus neuropeptides capa receptor 0.0208 0.0664 0.0869
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0034 0.0388
Echinococcus multilocularis cathepsin b 0.0734 0.2581 0.3384
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0086 0.022 0.2496
Loa Loa (eye worm) hypothetical protein 0.0053 0.0099 0.0099
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.0539 0.0704
Plasmodium falciparum serine repeat antigen 1 0.0059 0.012 0.164
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0038 0.0038
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0059 0.012 0.1355
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0136 0.0136
Echinococcus granulosus rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Brugia malayi hypothetical protein 0.0208 0.0664 0.0664
Echinococcus granulosus g-protein coupled receptor 0.0208 0.0664 0.0869
Echinococcus granulosus 7tm_1 domain containing protein 0.0208 0.0664 0.0869
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0208 0.0664 0.0869
Schistosoma mansoni cathepsin C 0.0059 0.012 0.0157
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0208 0.0664 0.0869
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0208 0.0664 0.0664
Plasmodium falciparum serine repeat antigen 6 0.0059 0.012 0.164
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0046 0.0522
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0059 0.012 0.1355
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0208 0.0664 0.0871
Brugia malayi hypothetical protein 0.0208 0.0664 0.0664
Trypanosoma cruzi cysteine peptidase, putative 0.0227 0.0731 0.2833
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0208 0.0664 0.0664
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0046 0.0522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0227 0.0731 0.83
Brugia malayi cathepsin F-like cysteine proteinase 0.0059 0.012 0.012
Brugia malayi follicle stimulating hormone receptor 0.0208 0.0664 0.0664
Mycobacterium ulcerans lipase LipD 0.0037 0.004 0.0172
Echinococcus granulosus laminin 0.006 0.0123 0.0159
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0208 0.0664 0.0869
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1481 0.5304 0.6955
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0046 0.0074 0.0074
Onchocerca volvulus 0.0227 0.0731 1
Brugia malayi hypothetical protein 0.0208 0.0664 0.0664
Loa Loa (eye worm) matrixin family protein 0.0084 0.0212 0.0212
Onchocerca volvulus Huntingtin homolog 0.0131 0.0382 0.5207
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0059 0.012 0.1361
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0115 0.0148
Schistosoma mansoni hypothetical protein 0.0173 0.0537 0.0704
Schistosoma mansoni calpain (C02 family) 0.0086 0.022 0.0288
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.012 0.012
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0208 0.0664 0.0871
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0268 0.0881 0.3414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0731 0.83
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.0644 0.0843
Loa Loa (eye worm) calpain 5 0.006 0.0125 0.0125
Trypanosoma cruzi major cysteine proteinase, putative 0.0059 0.012 0.0465
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Echinococcus granulosus tachykinin peptides receptor 99D 0.1481 0.5304 0.6955
Schistosoma mansoni myosin xvIII 0.0208 0.0664 0.0871
Trypanosoma cruzi kinesin, putative 0.006 0.0125 0.0486
Brugia malayi fibroinase precursor 0.0059 0.012 0.012
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0049 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0227 0.0731 0.83
Echinococcus multilocularis sex peptide receptor 0.0208 0.0664 0.0869
Echinococcus multilocularis neuropeptides capa receptor 0.0208 0.0664 0.0869
Brugia malayi ORL1-like opioid receptor 0.0208 0.0664 0.0664
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0345 0.4712
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.012 0.1361
Brugia malayi Dopamine receptor 0.0208 0.0664 0.0664
Entamoeba histolytica cysteine protease, putative 0.0127 0.0368 0.5029
Brugia malayi Cathepsin L-like precursor 0.0227 0.0731 0.0731
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0024 0.0273
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.004 0.0076
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0059 0.012 0.164
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0059 0.012 0.1361
Onchocerca volvulus 0.0208 0.0664 0.9077
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.06 0.0785
Brugia malayi G-protein coupled receptor 0.0208 0.0664 0.0664
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0227 0.0731 0.83
Onchocerca volvulus Matrix metalloproteinase homolog 0.0084 0.0212 0.2885
Entamoeba histolytica cysteine protease, putative 0.0127 0.0368 0.5029
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.012
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0093 0.1052
Brugia malayi RE15519p 0.0208 0.0664 0.0664
Onchocerca volvulus Huntingtin homolog 0.0131 0.0382 0.5207
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0208 0.0664 0.0664
Echinococcus granulosus 6 phosphofructokinase 0.012 0.0345 0.045
Plasmodium falciparum plasmepsin II 0.005 0.0087 0.1187
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0127 0.0368 0.0482
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.004 0.0076
Loa Loa (eye worm) hypothetical protein 0.0159 0.0484 0.0484
Leishmania major hypothetical protein, conserved 0.0037 0.004 0.0449
Plasmodium vivax unspecified product 0.0059 0.012 0.1355
Leishmania major ATP-dependent phosphofructokinase 0.012 0.0345 0.3911
Echinococcus multilocularis cathepsin L 0.0127 0.0368 0.048
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0208 0.0664 0.0664
Brugia malayi TAR-binding protein 0.0063 0.0136 0.0136
Brugia malayi Calcium binding EGF domain containing protein 0.006 0.0123 0.0123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0024 0.0273
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0153 0.0594
Echinococcus multilocularis Tolloid protein 1 0.0185 0.0581 0.076
Brugia malayi G protein-coupled receptor 0.0208 0.0664 0.0664
Brugia malayi cathepsin F-like cysteine proteinase 0.0068 0.0153 0.0153
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0208 0.0664 0.0664
Onchocerca volvulus 0.0208 0.0664 0.9077
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0089 0.0115
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0208 0.0664 0.0871
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0136 0.0178
Trypanosoma brucei calpain-like protein, putative 0.0086 0.022 0.2496
Trypanosoma cruzi cysteine proteinase, putative 0.0127 0.0368 0.1425
Echinococcus multilocularis neuropeptide receptor A26 0.0208 0.0664 0.0869
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0068 0.0153 0.0153
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0034 0.0003
Plasmodium falciparum plasmepsin IV 0.005 0.0087 0.1187
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0208 0.0664 0.0869
Giardia lamblia Cathepsin B precursor 0.0059 0.012 0.1118
Brugia malayi AKH receptor 0.0208 0.0664 0.0664
Onchocerca volvulus 0.0037 0.004 0.0517
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0059 0.012 0.1118
Onchocerca volvulus Matrilysin homolog 0.0038 0.0044 0.0575
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0086 0.022 0.0852
Loa Loa (eye worm) MBCTL1 0.0057 0.0115 0.0115
Giardia lamblia Cathepsin B precursor 0.0059 0.012 0.1118
Toxoplasma gondii cathepsin CPC2 0.0059 0.012 0.1361
Echinococcus granulosus neuropeptide receptor 0.0208 0.0664 0.0869
Echinococcus multilocularis neuropeptide Y receptor 0.0208 0.0664 0.0869
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0734 0.2581 0.3385
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0086 0.022 0.0852
Loa Loa (eye worm) TYRA-2 protein 0.0208 0.0664 0.0664
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.006 0.0123 0.0123
Giardia lamblia Cathepsin L precursor 0.0059 0.012 0.1118
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0208 0.0664 0.0869
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0136 0.0178
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0059 0.012 0.164
Echinococcus granulosus neuropeptide receptor 0.0208 0.0664 0.0869
Loa Loa (eye worm) hypothetical protein 0.0046 0.0074 0.0074
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0208 0.0664 0.0869
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0024 0.0273
Toxoplasma gondii calcium binding egf domain-containing protein 0.006 0.0123 0.14
Schistosoma mansoni Mername-AA248 (C02 family) 0.0086 0.022 0.0288
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0049 0.0062
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0089 0.0117
Brugia malayi Cathepsin L-like precursor 0.0159 0.0484 0.0484
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0059 0.012 0.1355
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0046 0.0629
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0046 0.0522
Schistosoma mansoni microtubule-associated protein tau 0.2118 0.7626 1
Schistosoma mansoni alpha glucosidase 0.0039 0.0046 0.006
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0138 0.0409 0.0533
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0046 0.0522
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0049 0.019
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0059 0.012 0.1118
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.06 0.0785
Echinococcus multilocularis cathepsin L cysteine protease 0.0227 0.0731 0.0957
Loa Loa (eye worm) G-protein coupled receptor 0.0208 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0068 0.0153 0.0153
Trypanosoma cruzi cysteine peptidase, putative 0.0227 0.0731 0.2833
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0731 0.83
Giardia lamblia Cathepsin B precursor 0.0268 0.0881 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0059 0.012 0.164
Brugia malayi larval opioid receptor 0.0208 0.0664 0.0664
Plasmodium falciparum serine repeat antigen 3 0.0059 0.012 0.164
Entamoeba histolytica cysteine proteinase 2 0.0127 0.0368 0.5029
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0089 0.0115
Mycobacterium ulcerans hypothetical protein 0.0037 0.004 0.0172
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0049 0.0557
Plasmodium falciparum serine repeat antigen 7 0.0059 0.012 0.164
Echinococcus granulosus calpain 5 0.0086 0.022 0.0286
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0208 0.0664 0.0871
Schistosoma mansoni adenoreceptor 0.0208 0.0664 0.0871
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0208 0.0664 0.0869
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.012 0.012
Echinococcus granulosus cathepsin L cysteine protease 0.0127 0.0368 0.048
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0345 0.3911
Loa Loa (eye worm) beta-lactamase 0.0037 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Schistosoma mansoni cathepsin F (C01 family) 0.0227 0.0731 0.0959
Plasmodium vivax serine-repeat antigen (SERA) 0.0059 0.012 0.1355
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0127 0.0368 0.0482
Schistosoma mansoni cathepsin S (C01 family) 0.0059 0.012 0.0157
Echinococcus granulosus tm gpcr rhodopsin 0.0208 0.0664 0.0869
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0099 0.0099
Brugia malayi Melatonin receptor type 1A 0.0208 0.0664 0.0664
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0136 0.0136
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0136 0.0175
Brugia malayi cathepsin L precursor 0.0059 0.012 0.012
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0127 0.0368 0.1425
Brugia malayi mbt repeat family protein 0.005 0.0089 0.0089
Plasmodium falciparum plasmepsin VI 0.005 0.0087 0.1187
Echinococcus granulosus tm gpcr rhodopsin 0.0208 0.0664 0.0869
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0345 0.3911
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0086 0.022 0.2496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0731 0.83
Brugia malayi 6-phosphofructokinase 0.012 0.0345 0.0345
Loa Loa (eye worm) cysteine protease 0.0227 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Brugia malayi hypothetical protein 0.0208 0.0664 0.0664
Giardia lamblia Cysteine protease 0.0059 0.012 0.1118
Leishmania major cathepsin L-like protease 0.0227 0.0731 0.83
Schistosoma mansoni neuropeptide receptor 0.0208 0.0664 0.0871
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Entamoeba histolytica cysteine protease, putative 0.0127 0.0368 0.5029
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0046 0.0522
Entamoeba histolytica cysteine proteinase, putative 0.0127 0.0368 0.5029
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.012 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0227 0.0731 0.83
Echinococcus multilocularis fmrfamide receptor 0.0208 0.0664 0.0869
Entamoeba histolytica cysteine proteinase, putative 0.0127 0.0368 0.5029
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0115 0.0151
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0208 0.0664 0.0871
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.012 0.0157
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.062
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0086 0.022 0.0852
Schistosoma mansoni histamine h1 receptor 0.0208 0.0664 0.0871
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Schistosoma mansoni hypothetical protein 0.0208 0.0664 0.0871
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0208 0.0664 0.0869
Echinococcus granulosus tm gpcr rhodopsin 0.0208 0.0664 0.0869
Onchocerca volvulus 0.0208 0.0664 0.9077
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0024 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.0484 0.5487
Loa Loa (eye worm) hypothetical protein 0.0037 0.004 0.004
Loa Loa (eye worm) calpain 0.0086 0.022 0.022
Echinococcus granulosus peptide allatostatin:somatostatin 0.0208 0.0664 0.0869
Schistosoma mansoni hypothetical protein 0.0054 0.0102 0.0133
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0345 0.4712
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.0539 0.0704
Schistosoma mansoni hypothetical protein 0.0208 0.0664 0.0871
Echinococcus multilocularis calpain 0.0086 0.022 0.0286
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0208 0.0664 0.0664
Echinococcus granulosus rhodopsin orphan GPCR 0.0208 0.0664 0.0869
Brugia malayi hypothetical protein 0.0208 0.0664 0.0664
Brugia malayi cathepsin Z-like cysteine proteinase 0.0059 0.012 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0731 0.83
Entamoeba histolytica cysteine protease, putative 0.0059 0.012 0.164
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0049 0.067
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0153 0.0594
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0208 0.0664 0.0871
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0208 0.0664 0.0871
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.062
Echinococcus multilocularis geminin 0.0173 0.0537 0.0701
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0034 0.0443
Schistosoma mansoni neuropeptide F-like receptor 0.0208 0.0664 0.0871
Echinococcus multilocularis hypothetical protein 0.0086 0.022 0.0286
Brugia malayi RNA binding protein 0.0063 0.0136 0.0136
Leishmania major cysteine peptidase A (CPA) 0.0227 0.0731 0.83
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0059 0.012 0.1361
Echinococcus granulosus cathepsin L 0.0059 0.012 0.0155
Brugia malayi Matrixin family protein 0.0038 0.0044 0.0044
Schistosoma mansoni cathepsin s 0.0068 0.0153 0.0201
Brugia malayi Papain family cysteine protease containing protein 0.0227 0.0731 0.0731
Onchocerca volvulus 0.0208 0.0664 0.9077
Plasmodium falciparum cysteine proteinase falcipain 3 0.0227 0.0731 1
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0131 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0036 0.0038 0.0038
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0734 0.2581 0.3385
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0731 0.83
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0208 0.0664 0.0869
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0024 0.0329
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.005 0.0087 0.0114
Schistosoma mansoni amine GPCR 0.0208 0.0664 0.0871
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0046 0.0629
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Trypanosoma brucei cysteine peptidase C (CPC) 0.0268 0.0881 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.006 0.0123 0.14
Schistosoma mansoni neuropeptide receptor 0.0208 0.0664 0.0871
Brugia malayi cathepsin L-like precursor 0.0159 0.0484 0.0484
Plasmodium vivax hypothetical protein, conserved 0.0037 0.004 0.0218
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0086 0.022 0.2496
Onchocerca volvulus Matrilysin homolog 0.0084 0.0212 0.2885
Brugia malayi Serotonin receptor 0.0208 0.0664 0.0664
Mycobacterium tuberculosis Conserved protein 0.0037 0.004 0.0076
Brugia malayi Dopamine receptor protein 2 0.0208 0.0664 0.0664
Brugia malayi beta-lactamase family protein 0.0037 0.004 0.004
Schistosoma mansoni cathepsin F (C01 family) 0.0159 0.0484 0.0634
Schistosoma mansoni neuropeptide receptor 0.0208 0.0664 0.0871
Loa Loa (eye worm) hypothetical protein 0.0059 0.012 0.012
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.004 0.0051 0.0068
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0239 0.0777 0.1019
Loa Loa (eye worm) hypothetical protein 0.0131 0.0382 0.0382
Toxoplasma gondii aspartyl protease ASP1 0.005 0.0087 0.0985
Plasmodium falciparum serine repeat antigen 4 0.0059 0.012 0.164
Loa Loa (eye worm) phosphofructokinase 0.012 0.0345 0.0345
Brugia malayi MH2 domain containing protein 0.0117 0.0332 0.0332
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0136 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0059 0.012 0.1361
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0034 0.0388
Giardia lamblia Hypothetical protein 0.0059 0.012 0.1118
Echinococcus multilocularis fmrfamide receptor 0.0208 0.0664 0.0869
Onchocerca volvulus Neuropeptide F receptor homolog 0.0208 0.0664 0.9077
Echinococcus multilocularis neuropeptide Y receptor 0.0208 0.0664 0.0869
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0054 0.0101 0.0101
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0059 0.012 0.0157
Entamoeba histolytica cysteine protease, putative 0.0127 0.0368 0.5029
Onchocerca volvulus 0.0208 0.0664 0.9077
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0208 0.0664 0.0664
Plasmodium vivax aspartyl proteinase, putative 0.005 0.0087 0.0887
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0208 0.0664 0.0871
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.012 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.012 0.1361
Echinococcus granulosus geminin 0.0173 0.0537 0.0701
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0089 0.0117
Echinococcus multilocularis calpain 5 0.0086 0.022 0.0286
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0089 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.012 0.1361
Onchocerca volvulus 0.0059 0.012 0.1619
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.004 0.0076
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.004 0.004
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0059 0.012 0.0157
Loa Loa (eye worm) hypothetical protein 0.0026 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0227 0.0731 0.83
Echinococcus multilocularis pyruvate kinase 0.0028 0.0007 0.0007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.004 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0368 0.4174
Giardia lamblia Cathepsin L-like protease 0.0059 0.012 0.1118
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0227 0.0731 0.83
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0185 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0208 0.0664 0.0664
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0034 0.0007
Onchocerca volvulus 0.0208 0.0664 0.9077

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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