Detailed information for compound 726056

Basic information

Technical information
  • TDR Targets ID: 726056
  • Name: N-(2-chlorophenyl)-2-(1-methyltetrazol-5-yl)s ulfanylacetamide
  • MW: 283.737 | Formula: C10H10ClN5OS
  • H donors: 1 H acceptors: 4 LogP: 1.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1Cl)CSc1nnnn1C
  • InChi: 1S/C10H10ClN5OS/c1-16-10(13-14-15-16)18-6-9(17)12-8-5-3-2-4-7(8)11/h2-5H,6H2,1H3,(H,12,17)
  • InChiKey: ZFIJLLMJRLHJPU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-chlorophenyl)-2-(1-methyltetrazol-5-yl)sulfanyl-acetamide
  • N-(2-chlorophenyl)-2-[(1-methyl-5-tetrazolyl)thio]acetamide
  • N-(2-chlorophenyl)-2-[(1-methyltetrazol-5-yl)thio]acetamide
  • N-(2-chlorophenyl)-2-[(1-methyl-1,2,3,4-tetrazol-5-yl)sulfanyl]ethanamide
  • BAS 02832981
  • N-(2-Chloro-phenyl)-2-(1-methyl-1H-tetrazol-5-ylsulfanyl)-acetamide
  • IVK/0015247
  • MLS000097458
  • SMR000067745
  • AG-690/40700302
  • ZINC00421102

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0755 0.9723
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0099 0.1357 0.1357
Schistosoma mansoni cpg binding protein 0.0031 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0035 0.0403 0.0734
Loa Loa (eye worm) hypothetical protein 0.0043 0.0531 0.0972
Loa Loa (eye worm) hypothetical protein 0.0043 0.0531 0.0972
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0814 0.0814
Onchocerca volvulus 0.0043 0.0531 0.1406
Mycobacterium ulcerans hypothetical protein 0.0043 0.0531 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0266 1
Brugia malayi TAR-binding protein 0.0063 0.0814 0.2646
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0028 0.0028
Loa Loa (eye worm) MBCTL1 0.0066 0.0859 0.158
Loa Loa (eye worm) hypothetical protein 0.0036 0.0427 0.078
Loa Loa (eye worm) RNA binding protein 0.0063 0.0814 0.1498
Brugia malayi CXXC zinc finger family protein 0.0031 0.0345 0.1108
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0531 1
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0214 0.306 0.5662
Loa Loa (eye worm) hypothetical protein 0.0084 0.1125 0.2074
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0531 1
Onchocerca volvulus 0.0099 0.1357 0.4211
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0345 0.0628
Brugia malayi AEL166Cp 0.0016 0.0117 0.0363
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0531 0.0531
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0016 0.0117 0.0117
Echinococcus granulosus snurportin 1 0.0372 0.54 0.54
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.074 0.074
Brugia malayi hypothetical protein 0.0016 0.0117 0.0363
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.074 0.074
Echinococcus granulosus transferase 0.0016 0.0117 0.0117
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0006 0.0006
Onchocerca volvulus 0.0214 0.306 1
Echinococcus granulosus smad 0.0008 0.0006 0.0006
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0427 0.1378
Entamoeba histolytica hypothetical protein 0.0028 0.0305 1
Schistosoma mansoni hypothetical protein 0.0079 0.1055 0.1055
Echinococcus multilocularis Smad4 0.0008 0.0006 0.0006
Brugia malayi beta-lactamase family protein 0.0043 0.0531 0.1717
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0531 1
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.006 0.0769 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0028 0.0028
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0099 0.1357 0.2503
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0016 0.0117 0.0205
Echinococcus multilocularis ectonucleotide 0.0084 0.1125 0.1125
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0016 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0079 0.1055 0.1944
Echinococcus granulosus tar DNA binding protein 0.0063 0.0814 0.0814
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0099 0.1357 0.1357
Schistosoma mansoni ran 0.0026 0.0266 0.0266
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0814 0.0814
Toxoplasma gondii ABC1 family protein 0.0043 0.0531 0.5262
Schistosoma mansoni hypothetical protein 0.0036 0.0427 0.0427
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.074 0.074
Plasmodium falciparum importin beta, putative 0.0035 0.0403 1
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.006 0.0769 1
Onchocerca volvulus 0.0058 0.074 0.2117
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0016 0.0117 0.0117
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0266 0.0266
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0531 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0531 0.5262
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0427 0.1378
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0531 0.5262
Onchocerca volvulus 0.0043 0.0531 0.1406
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.4007 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0099 0.1357 0.1357
Brugia malayi beta-lactamase 0.0043 0.0531 0.1717
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0043 0.0531 0.0972
Schistosoma mansoni hypothetical protein 0.0036 0.0427 0.0427
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.006 0.0769 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0403 0.515
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0427 0.0427
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0099 0.1357 0.4421
Brugia malayi hypothetical protein 0.0016 0.0117 0.0363
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.1055 0.3434
Echinococcus multilocularis Endonuclease G 0.006 0.0769 0.0769
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.006 0.0769 1
Onchocerca volvulus 0.0043 0.0531 0.1406
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0305 0.1461
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0531 0.0531
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.3253 0.3253
Echinococcus multilocularis smad 0.0008 0.0006 0.0006
Schistosoma mansoni ran 0.0026 0.0266 0.0266
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0099 0.1357 0.1357
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.074 0.074
Echinococcus granulosus cpg binding protein 0.0033 0.0371 0.0371
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0016 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0099 0.1357 0.2503
Trichomonas vaginalis esterase, putative 0.0043 0.0531 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0531 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.074 0.074
Brugia malayi RNA, U transporter 1 0.0099 0.1355 0.4415
Brugia malayi mbt repeat family protein 0.0058 0.074 0.2403
Brugia malayi Thrombospondin type 1 domain containing protein 0.0214 0.306 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.074 0.1361
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.3253 0.3253
Schistosoma mansoni endonuclease related 0.006 0.0769 0.0769
Leishmania major endonuclease G, putative 0.006 0.0769 1
Schistosoma mansoni hypothetical protein 0.0016 0.0117 0.0117
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0305 0.0769
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0859 0.0859
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0016 0.0117 0.0363
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0266 0.5219
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0427 0.078
Loa Loa (eye worm) beta-lactamase 0.0043 0.0531 0.0972
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0266 0.0266
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0814 0.0814
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0859 0.0859
Schistosoma mansoni hypothetical protein 0.0036 0.0427 0.0427
Entamoeba histolytica Ran family GTPase 0.0026 0.0266 0.7937
Loa Loa (eye worm) hypothetical protein 0.0016 0.0117 0.0205
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0305 0.1461
Trypanosoma cruzi endonuclease G, putative 0.006 0.0769 1
Echinococcus granulosus dnaJ subfamily B 0.0441 0.6422 0.6422
Onchocerca volvulus 0.0099 0.1357 0.4211
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0099 0.1357 0.1357
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0859 0.0859
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.074 0.074
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0006 0.0006
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0266 0.0481
Trypanosoma cruzi endonuclease G, putative 0.006 0.0769 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0099 0.1357 0.1357
Schistosoma mansoni cpg binding protein 0.0033 0.0371 0.0371
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0859 0.0859
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0403 0.4374
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0099 0.1357 0.1357
Trypanosoma brucei endonuclease G, putative 0.006 0.0769 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.1596 0.5206
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0099 0.1357 0.1357
Schistosoma mansoni hypothetical protein 0.0441 0.6422 0.6422
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0016 0.0117 0.0117
Schistosoma mansoni cpg binding protein 0.0033 0.0371 0.0371
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0859 0.0859
Echinococcus multilocularis dnaJ subfamily B 0.0441 0.6422 0.6422
Schistosoma mansoni microtubule-associated protein tau 0.0682 1 1
Schistosoma mansoni hypothetical protein 0.0372 0.54 0.54
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0427 0.0427
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0531 1
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0016 0.0117 0.0205
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.074 0.074
Echinococcus multilocularis snurportin 1 0.0372 0.54 0.54
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0531 0.1717
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0531 0.0531
Schistosoma mansoni hypothetical protein 0.0214 0.306 0.306
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0006
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0403 0.0403
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0266 0.2283
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0099 0.1357 0.1357
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0403 0.4374
Brugia malayi Importin beta-1 subunit 0.0035 0.0403 0.1297
Loa Loa (eye worm) histone methyltransferase 0.001 0.0028 0.004
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0084 0.1125 0.1125
Schistosoma mansoni hypothetical protein 0.0016 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.0016 0.0117 0.0117
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.074 0.2117
Echinococcus multilocularis transferase 0.0016 0.0117 0.0117
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0016 0.0117 0.0117
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0026 0.0065
Leishmania major GTP-binding protein, putative 0.0026 0.0266 0.2283
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0531 1
Onchocerca volvulus 0.0031 0.0345 0.0773
Loa Loa (eye worm) hypothetical protein 0.0043 0.0531 0.0972
Brugia malayi MH2 domain containing protein 0.0119 0.1654 0.5394
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0403 0.271
Trypanosoma brucei endonuclease G, putative 0.006 0.0769 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0531 0.0972
Echinococcus granulosus Endonuclease G 0.006 0.0769 0.0769
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0084 0.1125 0.1125
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0099 0.1357 0.1357
Schistosoma mansoni hypothetical protein 0.035 0.508 0.508
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0016 0.0117 0.0117
Mycobacterium leprae Probable lipase LipE 0.0043 0.0531 1
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1654 0.3054
Echinococcus granulosus importin subunit beta 1 0.0035 0.0403 0.0403
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0814 0.0814
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0006 0.0006
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1654 0.3054
Echinococcus multilocularis GPCR, family 2 0.0036 0.0427 0.0427
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0099 0.1357 0.1357
Echinococcus multilocularis cpg binding protein 0.0033 0.0371 0.0371
Echinococcus granulosus ectonucleotide 0.0084 0.1125 0.1125
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0814 0.1498
Loa Loa (eye worm) hypothetical protein 0.0115 0.1596 0.2948
Echinococcus multilocularis microtubule associated protein 2 0.0682 1 1
Echinococcus granulosus GPCR family 2 0.0036 0.0427 0.0427
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0859 0.2791
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.1596 0.5206
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.1596 0.2948
Mycobacterium ulcerans lipase LipD 0.0043 0.0531 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0099 0.1357 0.1357
Loa Loa (eye worm) hypothetical protein 0.0016 0.0117 0.0205
Brugia malayi RNA binding protein 0.0063 0.0814 0.2646
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0099 0.1357 0.1357
Schistosoma mansoni Smad4 0.0008 0.0006 0.0006
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.54 1
Brugia malayi beta-lactamase family protein 0.0043 0.0531 0.1717
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0531 0.6343
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0305 0.1461
Leishmania major hypothetical protein, conserved 0.0043 0.0531 0.6343
Schistosoma mansoni hypothetical protein 0.0036 0.0427 0.0427
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0814 0.0814
Mycobacterium ulcerans beta-lactamase 0.0043 0.0531 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0859 0.0859
Loa Loa (eye worm) hypothetical protein 0.0016 0.0117 0.0205
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0814 0.0814
Loa Loa (eye worm) hypothetical protein 0.0066 0.0859 0.158
Schistosoma mansoni importin beta-1 0.0035 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0043 0.0531 0.0972
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0006 0.0006
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0814 0.1498
Trypanosoma brucei endonuclease G, putative 0.006 0.0769 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0531 0.0531
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0016 0.0117 0.0117
Echinococcus granulosus Smad4 0.0008 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0043 0.0531 0.0972
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.074 0.1361
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0099 0.1357 0.1357
Schistosoma mansoni smad 0.0008 0.0006 0.0006
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0006 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0531 1
Brugia malayi endonuclease G, mitochondrial precursor 0.006 0.0769 0.2498
Leishmania major importin beta-1 subunit, putative 0.0028 0.0305 0.2876
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0531 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0099 0.1357 0.1357
Loa Loa (eye worm) hypothetical protein 0.0099 0.1357 0.2503
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0266 0.085
Schistosoma mansoni hypothetical protein 0.0016 0.0117 0.0117
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0814 0.2646
Brugia malayi mbt repeat family protein 0.0058 0.074 0.2403

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0058 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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