Detailed information for compound 728467

Basic information

Technical information
  • TDR Targets ID: 728467
  • Name: N-(3-chlorophenyl)-2-[(3,5-dimethylphenyl)-me thylsulfonylamino]propanamide
  • MW: 380.889 | Formula: C18H21ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.73 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)NC(=O)C(N(S(=O)(=O)C)c1cc(C)cc(c1)C)C
  • InChi: 1S/C18H21ClN2O3S/c1-12-8-13(2)10-17(9-12)21(25(4,23)24)14(3)18(22)20-16-7-5-6-15(19)11-16/h5-11,14H,1-4H3,(H,20,22)
  • InChiKey: JRONWGPOSBSRGZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chlorophenyl)-2-[(3,5-dimethylphenyl)-methylsulfonyl-amino]propanamide
  • N-(3-chlorophenyl)-2-[(3,5-dimethylphenyl)-mesyl-amino]propionamide
  • CBKinase1_021062
  • CBKinase1_008662

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0018 0.0022 0.0029
Trichomonas vaginalis CMGC family protein kinase 0.0019 0.0026 0.0131
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0044 0.0044
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0115 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0115 0.1317
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0014 0.001 0.0013
Schistosoma mansoni sodium/chloride dependent transporter 0.0029 0.0067 0.0132
Schistosoma mansoni alpha-glucosidase 0.0107 0.0372 0.0726
Onchocerca volvulus 0.0018 0.0022 0.0024
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.001 0.0019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0154 0.0301
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0337 0.1273 0.1658
Brugia malayi vesicular acetylcholine transporter unc-17 0.132 0.5124 0.667
Loa Loa (eye worm) hypothetical protein 0.011 0.0385 0.0502
Schistosoma mansoni inositol monophosphatase 0.0019 0.0029 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0006 0.0008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0099 0.0194
Trichomonas vaginalis penicillin-binding protein, putative 0.0185 0.0679 0.3491
Schistosoma mansoni hypothetical protein 0.0051 0.0154 0.0301
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0205 0.04
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0029
Echinococcus multilocularis protein dispatched 1 0.0054 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.1241 0.4815 0.9398
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0053 0.0273
Loa Loa (eye worm) hypothetical protein 0.0168 0.0611 0.0796
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0029
Schistosoma mansoni sodium/chloride dependent transporter 0.0029 0.0065 0.0126
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.003 0.0039
Toxoplasma gondii hypothetical protein 0.0029 0.0065 0.0598
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.035 0.1798
Echinococcus multilocularis cyclin dependent kinase 0.0019 0.0026 0.0026
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.007 0.0681
Toxoplasma gondii ABC1 family protein 0.0185 0.0679 1
Loa Loa (eye worm) inositol-1 0.0019 0.0029 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0029
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.0387 0.0504
Brugia malayi cell division control protein 2 homolog 0.0019 0.0026 0.0033
Echinococcus multilocularis lysine specific demethylase 6a 0.003 0.0069 0.0069
Echinococcus multilocularis snurportin 1 0.0337 0.1272 0.1272
Trypanosoma brucei polo-like protein kinase 0.0101 0.035 0.0455
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0185 0.0679 0.0884
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0022 0.0043
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0014 0.001 0.0019
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.007 0.0091
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0011 0.0011
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0099 0.0194
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0084
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0112 0.039 0.0761
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0099 0.0129
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0061 0.0313
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0185 0.0679 0.1325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0099 0.0129
Echinococcus granulosus expressed protein 0.0014 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0168 0.0611 0.0796
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0039
Onchocerca volvulus 0.0015 0.0012 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0099 0.0099
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0026 0.005
Echinococcus granulosus JmjC domain containing protein 4 0.003 0.0069 0.0134
Onchocerca volvulus 0.0031 0.0073 0.0124
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0011 0.0021
Loa Loa (eye worm) hypothetical protein 0.0168 0.0611 0.0796
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0029 0.0065 0.0084
Schistosoma mansoni alpha-glucosidase 0.0107 0.0372 0.0726
Echinococcus multilocularis PHD finger protein rhinoceros 0.0091 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0096
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.003 0.0059
Echinococcus granulosus vesicular acetylcholine transporter 0.132 0.5124 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0044 0.0057
Echinococcus granulosus lysosomal alpha glucosidase 0.0124 0.044 0.0858
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.035 0.0683
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0061 0.0313
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0014 0.001 0.0019
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0195 0.038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0337 0.1273 0.2485
Trypanosoma cruzi cdc2-related kinase 3 0.0019 0.0026 0.0033
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0029 0.0065 0.0084
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0044 0.0057
Loa Loa (eye worm) hypothetical protein 0.0185 0.0679 0.0884
Schistosoma mansoni sodium-dependent amino acid transporter 0.0029 0.0065 0.0126
Schistosoma mansoni kinase 0.0052 0.0155 0.0303
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.003 0.0069 0.0089
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.003 0.0039
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0185 0.0679 0.1439
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0061 0.1365
Echinococcus multilocularis sodium and chloride dependent glycine 0.0029 0.0065 0.0065
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0014 0.001 0.0013
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.03 0.1127 0.2199
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0032 0.0078 0.0078
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0099 0.0194
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0029 0.0065 0.0126
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0029
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.003 0.003
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.001 0.0019
Mycobacterium tuberculosis Conserved protein 0.0185 0.0679 0.1439
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1972 0.7681 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0019 0.0029 0.015
Brugia malayi jmjC domain containing protein 0.003 0.0069 0.0089
Echinococcus multilocularis cpg binding protein 0.0016 0.0016 0.0016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0099 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0099 0.0129
Loa Loa (eye worm) DR-78 0.0018 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0039
Echinococcus multilocularis expressed protein 0.0014 0.001 0.001
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0029 0.0065 0.0126
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0022 0.0043
Brugia malayi tailless protein 0.0018 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0091 0.0311 0.0405
Loa Loa (eye worm) jmjC domain-containing protein 0.0112 0.039 0.0508
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0154 0.0301
Loa Loa (eye worm) hypothetical protein 0.0037 0.0099 0.0129
Brugia malayi intermediate filament protein 0.0031 0.0073 0.0095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0099 0.0194
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.003 0.0039
Schistosoma mansoni inositol monophosphatase 0.0019 0.0029 0.0057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0154 0.0201
Brugia malayi Protein kinase domain containing protein 0.0019 0.0026 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0013
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0115 0.1366
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0084
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0076 0.01
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0073 0.0095
Schistosoma mansoni lamin 0.0031 0.0073 0.0143
Trypanosoma cruzi cdc2-related kinase 1 0.0019 0.0026 0.0033
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0205 0.04
Plasmodium vivax hypothetical protein, conserved 0.0091 0.0311 0.4372
Echinococcus granulosus dna polymerase eta 0.002 0.003 0.0059
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0115 0.0149
Echinococcus multilocularis p2X purinoceptor 4 0.009 0.0307 0.0307
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0039
Brugia malayi beta-lactamase 0.0185 0.0679 0.0884
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0099 0.0129
Brugia malayi PHD-finger family protein 0.0091 0.0311 0.0405
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.0385 0.0385
Schistosoma mansoni cpg binding protein 0.0016 0.0016 0.003
Brugia malayi CHE-14 protein 0.0047 0.0139 0.018
Echinococcus multilocularis lamin dm0 0.0031 0.0073 0.0073
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0061 0.0313
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0022 0.0043
Brugia malayi Pre-SET motif family protein 0.0447 0.1704 0.2218
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0029 0.0065 0.0126
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0014 0.001 0.005
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0019 0.0029 0.0038
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0029 0.0065 0.0084
Echinococcus multilocularis serotonin transporter 0.0168 0.0611 0.0611
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0014 0.001 0.0019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0337 0.1273 0.1273
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0032 0.0078 0.0125
Schistosoma mansoni importin beta-1 0.0032 0.0076 0.0149
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0115 0.0205
Schistosoma mansoni vesicular acetylcholine transporter 0.132 0.5124 1
Plasmodium vivax JmjC domain containing protein 0.003 0.0069 0.0659
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0029 0.0065 0.0084
Onchocerca volvulus 0.0064 0.0205 0.0382
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0039
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.132 0.5124 0.667
Plasmodium vivax importin-beta 2, putative 0.0032 0.0076 0.0779
Schistosoma mansoni P2X receptor subunit 0.009 0.0307 0.0599
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0099 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0039
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0053 0.0273
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0032 0.0078 0.0102
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.03 0.1127 0.1127
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.003 0.0543
Loa Loa (eye worm) hypothetical protein 0.0185 0.0679 0.0884
Schistosoma mansoni aldehyde dehydrogenase 0.0032 0.0078 0.0153
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.132 0.5124 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0044 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.035 0.0683
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0037 0.0099 0.0129
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0014 0.001 0.0019
Brugia malayi AF-10 protein 0.003 0.007 0.0091
Schistosoma mansoni hypothetical protein 0.003 0.007 0.0137
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0044 0.028
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0029 0.0065 0.0126
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0022 0.0043
Onchocerca volvulus 0.0185 0.0679 0.1309
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0115 0.0149
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0039
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0099 0.0099
Mycobacterium ulcerans lipase LipD 0.0185 0.0679 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0044 0.064
Brugia malayi hypothetical protein 0.0029 0.0065 0.0084
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0061 0.0313
Schistosoma mansoni aldehyde dehydrogenase 0.0032 0.0078 0.0153
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0031 0.0074 0.1684
Echinococcus granulosus dna polymerase kappa 0.002 0.003 0.0059
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0014 0.001 0.0013
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0124 0.044 0.0572
Plasmodium falciparum importin beta, putative 0.0032 0.0076 0.1782
Loa Loa (eye worm) hypothetical protein 0.0051 0.0154 0.0201
Brugia malayi jmjC domain containing protein 0.0112 0.039 0.0508
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0073 0.0095
Schistosoma mansoni hypothetical protein 0.0046 0.0132 0.0257
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0022 0.0024
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0115 0.0224
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0029 0.0065 0.0126
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0069 0.0089
Onchocerca volvulus 0.0029 0.0065 0.0108
Loa Loa (eye worm) hypothetical protein 0.1972 0.7681 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0091 0.0311 0.0608
Echinococcus multilocularis p2X purinoceptor 4 0.009 0.0307 0.0307
Brugia malayi nuclear hormone receptor 0.0037 0.0099 0.0129
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.035 0.0665
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0022 0.0029
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.007 0.0091
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0014 0.001 0.001
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0022 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0061 0.0313
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0019 0.0029 0.015
Onchocerca volvulus Alhambra homolog 0.0091 0.0311 0.059
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0139 0.027
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0022 0.0029
Brugia malayi jmjC domain containing protein 0.003 0.0069 0.0089
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.003 0.0059
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0065 0.0598
Loa Loa (eye worm) serotonin transporter b 0.0168 0.0611 0.0796
Plasmodium vivax amine transporter, putative 0.0029 0.0065 0.0598
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0072 0.014
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0154 0.0154
Echinococcus granulosus importin subunit beta 1 0.0032 0.0076 0.0149
Echinococcus multilocularis lysine specific demethylase 5A 0.0111 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0095 0.0324 0.0422
Trichomonas vaginalis CMGC family protein kinase 0.0019 0.0026 0.0131
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0162 0.0588 0.0766
Brugia malayi beta-lactamase family protein 0.0185 0.0679 0.0884
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.003 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0099 0.0129
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0185 0.0679 1
Brugia malayi nuclear receptor RXR 0.002 0.003 0.0039
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0014 0.001 0.005
Brugia malayi hypothetical protein 0.002 0.003 0.0039
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0029 0.0065 0.0126
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.003 0.0039
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0162 0.0588 0.0766
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0084
Schistosoma mansoni ap endonuclease 0.0041 0.0115 0.0224
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.0094 0.0183
Plasmodium vivax hypothetical protein, conserved 0.0185 0.0679 1
Schistosoma mansoni hypothetical protein 0.0046 0.0132 0.0257
Entamoeba histolytica cell division protein kinase 2, putative 0.0019 0.0026 0.0423
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.001 0.001
Brugia malayi Inositol-1 0.0019 0.0029 0.0038
Loa Loa (eye worm) PHD-finger family protein 0.0091 0.0311 0.0405
Echinococcus granulosus jumonji domain containing protein 0.0127 0.0452 0.0881
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0022 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.0679 0.0884
Trypanosoma brucei hypothetical protein, conserved 0.0185 0.0679 0.0884
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0337 0.1272 0.1655
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.035 0.0455
Loa Loa (eye worm) hypothetical protein 0.003 0.0069 0.0089
Loa Loa (eye worm) hypothetical protein 0.0185 0.0679 0.0884
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0084
Schistosoma mansoni GTP-binding protein alpha subunit 0.0014 0.001 0.0019
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0168 0.0611 0.1193
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0022 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0099 0.0129
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.001 0.001
Echinococcus granulosus intermediate filament protein 0.0031 0.0073 0.0143
Trypanosoma brucei cdc2-related kinase 3 0.0019 0.0026 0.0033
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0029
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0014 0.001 0.0013
Mycobacterium tuberculosis Probable lipase LipD 0.0185 0.0679 0.1439
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.001 0.0019
Onchocerca volvulus 0.0168 0.0611 0.1176
Brugia malayi F/Y-rich N-terminus family protein 0.0037 0.0097 0.0127
Schistosoma mansoni hypothetical protein 0.0216 0.0797 0.1556
Leishmania major GTP-binding protein, putative 0.0023 0.0044 0.0057
Toxoplasma gondii exonuclease III APE 0.0041 0.0115 0.1366
Trypanosoma cruzi cdc2-related kinase 1 0.0019 0.0026 0.0033
Echinococcus granulosus Niemann Pick C1 protein 0.0158 0.0571 0.1115
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0337 0.1273 0.2485
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0039
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.001 0.005
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0115 0.0149
Brugia malayi ecdysone receptor 0.0018 0.0022 0.0029
Trypanosoma brucei unspecified product 0.0014 0.0006 0.0008
Toxoplasma gondii hypothetical protein 0.0029 0.0065 0.0598
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0013
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0014 0.001 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0189 0.0693 0.0902
Echinococcus granulosus lysine specific demethylase 5A 0.0112 0.039 0.0761
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0337 0.1273 0.2485
Schistosoma mansoni phosphatidylserine receptor 0.003 0.0069 0.0134
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0044 0.0086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0099 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0099 0.0129
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.035 0.0455
Loa Loa (eye worm) hypothetical protein 0.0185 0.0679 0.0884
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0061 0.0079
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0205 0.04
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0029 0.0065 0.0126
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0095
Onchocerca volvulus 0.0072 0.0234 0.044
Brugia malayi Bromodomain containing protein 0.0091 0.0311 0.0405
Echinococcus multilocularis JmjC domain containing protein 4 0.003 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0039
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0053 0.0069
Trypanosoma brucei glucosidase, putative 0.0028 0.0061 0.0079
Schistosoma mansoni nuclear receptor 0.0018 0.0022 0.0043
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0185 0.0679 0.1325
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.035 0.1798
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0061 0.0313
Brugia malayi Glycosyl hydrolases family 31 protein 0.0124 0.044 0.0572
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0069 0.0089
Echinococcus granulosus muscleblind protein 0.0299 0.1124 0.2194
Brugia malayi G-protein alpha subunit 0.0014 0.001 0.0013
Echinococcus multilocularis geminin 0.1241 0.4815 0.4815
Echinococcus granulosus cyclin dependent kinase 0.0019 0.0026 0.005
Schistosoma mansoni ran 0.0023 0.0044 0.0086
Toxoplasma gondii aldehyde dehydrogenase 0.0032 0.0078 0.0807
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0022 0.0029
Plasmodium falciparum phd finger protein, putative 0.0091 0.0311 1
Mycobacterium leprae conserved hypothetical protein 0.0185 0.0679 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0099 0.0194
Schistosoma mansoni P2X receptor subunit 0.009 0.0307 0.0599
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0115 0.059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0032 0.0078 0.0756
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0107 0.0371 0.0483
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0061 0.0079
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0028 0.0061 0.0079
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.0385 0.0752
Loa Loa (eye worm) hypothetical protein 0.1008 0.3903 0.5081
Onchocerca volvulus 0.0509 0.1946 0.3785
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0014 0.001 0.0019
Echinococcus granulosus p2X purinoceptor 4 0.009 0.0307 0.0599
Echinococcus multilocularis beta LACTamase domain containing family member 0.0185 0.0679 0.0679
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0014 0.001 0.0019
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0017 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0026 0.005
Schistosoma mansoni lamin 0.0031 0.0073 0.0143
Echinococcus multilocularis lamin 0.0031 0.0073 0.0073
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0099 0.0194
Leishmania major DNA polymerase kappa, putative 0.002 0.003 0.0039
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0099 0.0194
Echinococcus multilocularis jumonji domain containing 1A 0.003 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0037 0.0099 0.0129
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.0679 0.3491
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0099 0.0194
Loa Loa (eye worm) solute carrier family 6 member 4 0.0168 0.0611 0.0796
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0099 0.0194
Loa Loa (eye worm) CXXC zinc finger family protein 0.0015 0.0012 0.0016
Entamoeba histolytica cell division protein kinase 2, putative 0.0019 0.0026 0.0423
Loa Loa (eye worm) beta-lactamase 0.0185 0.0679 0.0884
Leishmania major alpha glucosidase II subunit, putative 0.0028 0.0061 0.0079
Onchocerca volvulus 0.0029 0.0065 0.0108
Schistosoma mansoni P2X receptor subunit 0.009 0.0307 0.0599
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.0679 0.3491
Mycobacterium tuberculosis Probable lipase LipE 0.0185 0.0679 0.1439
Giardia lamblia DINP protein human, muc B family 0.002 0.003 0.0139
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0447 0.1704 0.2218
Schistosoma mansoni sodium/chloride dependent transporter 0.0168 0.0611 0.1193
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.035 0.9051
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0061 0.1365
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0006 0.0008
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0029 0.0065 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0039
Entamoeba histolytica Ran family GTPase 0.0023 0.0044 0.091
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.003 0.0039
Onchocerca volvulus 0.0031 0.0073 0.0124
Trichomonas vaginalis CMGC family protein kinase 0.0019 0.0026 0.0131
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0073 0.0095
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0099 0.0175
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0014 0.001 0.0019
Echinococcus multilocularis jumonji domain containing protein 0.0127 0.0452 0.0452
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0168 0.0611 0.0796
Echinococcus granulosus geminin 0.1241 0.4815 0.9398
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0064 0.0205 0.0267
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0011
Brugia malayi hypothetical protein 0.0018 0.0022 0.0029
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.035 0.1798
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.003 0.0039
Echinococcus multilocularis expressed conserved protein 0.0104 0.0359 0.0359
Treponema pallidum sodium- and chloride- dependent transporter 0.0168 0.0611 1
Trichomonas vaginalis esterase, putative 0.0185 0.0679 0.3491
Leishmania major importin beta-1 subunit, putative 0.0026 0.0053 0.0069
Echinococcus multilocularis p2X purinoceptor 4 0.009 0.0307 0.0307
Echinococcus multilocularis lysosomal alpha glucosidase 0.0124 0.044 0.044
Trypanosoma brucei unspecified product 0.002 0.003 0.0039
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.001 0.0019
Trypanosoma brucei unspecified product 0.0014 0.0006 0.0008
Echinococcus multilocularis dna polymerase eta 0.002 0.003 0.003
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.003 0.0039
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0099 0.0194
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0099 0.0129
Echinococcus granulosus sodium and chloride dependent glycine 0.0029 0.0065 0.0126
Loa Loa (eye worm) hypothetical protein 0.0299 0.1124 0.1463
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.003 0.0059
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.001 0.0019
Schistosoma mansoni cpg binding protein 0.0015 0.0012 0.0024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0099 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.0679 0.0884
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0029 0.0065 0.0126
Trypanosoma brucei C-8 sterol isomerase, putative 0.1972 0.7681 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0019 0.0029 0.015
Schistosoma mansoni hypothetical protein 0.0051 0.0154 0.0301
Plasmodium falciparum JmjC domain-containing protein, putative 0.003 0.0069 0.1507
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0029
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0022 0.0022
Schistosoma mansoni coup transcription factor 0.0037 0.0099 0.0194
Echinococcus multilocularis dnaJ subfamily B 0.0216 0.0797 0.0797
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0014 0.001 0.0019
Echinococcus multilocularis protein patched 0.0047 0.0139 0.0139
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0029 0.0065 0.0065
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0069 0.0089
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0019 0.0026 0.0033
Loa Loa (eye worm) hypothetical protein 0.0157 0.0567 0.0739
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.003 0.0039
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0099 0.0175
Schistosoma mansoni jumonji domain containing protein 0.003 0.0069 0.0134
Echinococcus multilocularis neutral alpha glucosidase AB 0.0028 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0084
Mycobacterium ulcerans DNA polymerase IV 0.002 0.003 0.0013
Brugia malayi Niemann-Pick C1 protein precursor 0.011 0.0385 0.0502
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.035 0.0455
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0019 0.0029 0.0038
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0029 0.0065 0.0598
Schistosoma mansoni hypothetical protein 0.0046 0.0132 0.0257
Trichomonas vaginalis ran, putative 0.0023 0.0044 0.0225
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0115 0.0149
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.0478 0.0622
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0069 0.0089
Brugia malayi ecdysteroid receptor 0.0037 0.0099 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0039
Schistosoma mansoni alpha glucosidase 0.0028 0.0061 0.0119
Brugia malayi Calcitonin receptor-like protein seb-1 0.0162 0.0588 0.0766
Trichomonas vaginalis CAMK family protein kinase 0.005 0.015 0.0772
Giardia lamblia PHD finger protein 15 0.0091 0.0311 0.8811
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.003
Echinococcus granulosus cpg binding protein 0.0016 0.0016 0.003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0031 0.0074 0.0749
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.001 0.001
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0099 0.0194
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.003 0.0154
Loa Loa (eye worm) hypothetical protein 0.0032 0.0076 0.01
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0205 0.04
Echinococcus multilocularis musashi 0.0031 0.0073 0.0073
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0099 0.0129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0099 0.0129
Echinococcus granulosus inositol monophosphatase 1 0.0019 0.0029 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.035 0.1798
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0014 0.001 0.0013
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0014 0.001 0.0013
Mycobacterium leprae Probable lipase LipE 0.0185 0.0679 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0115 0.3124
Echinococcus granulosus sodium and chloride dependent glycine 0.0029 0.0065 0.0126
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0115 0.0115
Brugia malayi beta-lactamase family protein 0.0185 0.0679 0.0884
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0115 0.0149
Toxoplasma gondii PHD-finger domain-containing protein 0.0091 0.0311 0.4372
Schistosoma mansoni protein phosphatase 2C 0.003 0.0069 0.0134
Loa Loa (eye worm) hypothetical protein 0.003 0.0071 0.0092
Loa Loa (eye worm) hypothetical protein 0.0103 0.0358 0.0466
Schistosoma mansoni zinc finger protein 0.0018 0.0022 0.0043
Onchocerca volvulus 0.0037 0.0099 0.0175
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.003 0.003
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0061 0.0313
Echinococcus granulosus phd:f box containing protein 0.003 0.0069 0.0134
Echinococcus granulosus lysine specific demethylase 6a 0.003 0.0069 0.0134
Echinococcus multilocularis cyclin dependent kinase 1 0.0019 0.0026 0.0026
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0019 0.0026 0.0033
Onchocerca volvulus 0.0185 0.0679 0.1309
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0115 0.2798
Schistosoma mansoni hypothetical protein 0.0091 0.0311 0.0608
Brugia malayi CXXC zinc finger family protein 0.0015 0.0012 0.0016
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0115 0.2753
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.003 0.0039
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.0478 0.0622
Loa Loa (eye worm) hypothetical protein 0.0058 0.018 0.0235
Mycobacterium ulcerans DNA polymerase IV 0.002 0.003 0.0013
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.001 0.0019
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0019 0.0029 0.052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0032 0.0078 0.0756
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0029 0.0065 0.5
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.001 0.0013
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0074 0.0736
Schistosoma mansoni ap endonuclease 0.0041 0.0115 0.0224
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0022 0.0043
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0044 0.0057
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0029 0.0065 0.0598
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0029 0.0065 0.0126
Toxoplasma gondii histone lysine demethylase JMJD6a 0.003 0.0069 0.0659
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0029
Echinococcus multilocularis peregrin 0.0091 0.0311 0.0311
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0019 0.0029 0.0056
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0337 0.1273 0.1658
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0099 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0029
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0029 0.0065 0.0598
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0154 0.0201
Schistosoma mansoni hypothetical protein 0.0051 0.0154 0.0301
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.001 0.0019
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0019 0.0029 0.0038
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.001 0.005
Brugia malayi hypothetical protein 0.002 0.003 0.0039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.003 0.0059
Trichomonas vaginalis CAMK family protein kinase 0.005 0.015 0.0772
Schistosoma mansoni cpg binding protein 0.0016 0.0016 0.003
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0022 0.0029
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0099 0.0194
Mycobacterium tuberculosis Probable hydrolase 0.0185 0.0679 0.1439
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.001 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0039
Echinococcus granulosus expressed conserved protein 0.0104 0.0359 0.0701
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0099 0.0129
Mycobacterium ulcerans aldehyde dehydrogenase 0.0032 0.0078 0.0756
Brugia malayi MH2 domain containing protein 0.0134 0.0478 0.0622
Leishmania major DNA polymerase eta, putative 0.002 0.003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0084
Schistosoma mansoni hypothetical protein 0.1241 0.4815 0.9398
Brugia malayi Muscleblind-like protein 0.0299 0.1124 0.1463
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0061 0.0313
Echinococcus granulosus lamin 0.0031 0.0073 0.0143
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0099 0.0194
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0185 0.0679 0.1439
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.003 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0099 0.0129
Leishmania major hypothetical protein, conserved 0.003 0.0069 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0099 0.0129
Trypanosoma cruzi cdc2-related kinase 3 0.0019 0.0026 0.0033
Schistosoma mansoni jumonji domain containing protein 0.0238 0.0885 0.1728
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0053 0.0273
Echinococcus granulosus cyclin dependent kinase 5 0.0019 0.0026 0.005
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0076 0.01
Loa Loa (eye worm) hypothetical protein 0.0037 0.0099 0.0129
Echinococcus multilocularis vesicular acetylcholine transporter 0.132 0.5124 0.5124
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0029 0.0065 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0006 0.0008
Echinococcus granulosus serotonin transporter 0.0168 0.0611 0.1193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0337 0.1273 0.2485
Loa Loa (eye worm) hypothetical protein 0.0185 0.0679 0.0884
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0107 0.0371 0.0724
Brugia malayi steroid hormone receptor 0.0037 0.0099 0.0129
Trypanosoma brucei cdc2-related kinase 1 0.0019 0.0026 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0099 0.0129
Echinococcus granulosus snurportin 1 0.0337 0.1272 0.2482
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.003 0.0059
Schistosoma mansoni ran 0.0023 0.0044 0.0086
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0139 0.018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0115 0.0149
Echinococcus multilocularis inositol monophosphatase 1 0.0019 0.0029 0.0029
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0099 0.0129
Schistosoma mansoni GTP-binding protein alpha subunit 0.0014 0.001 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.003 0.0039
Schistosoma mansoni hypothetical protein 0.0051 0.0154 0.0301
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0022 0.0043
Schistosoma mansoni DNA polymerase eta 0.002 0.003 0.0059
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0022 0.0022
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.003 0.0039
Brugia malayi hypothetical protein 0.0014 0.001 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0099 0.0129
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.0185 0.0679 0.3491
Brugia malayi nuclear receptor RXR 0.0018 0.0022 0.0029
Schistosoma mansoni patched 1 0.0047 0.0139 0.027
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0185 0.0679 0.0884
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0099 0.0129
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0099 0.0099
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0099 0.0129
Brugia malayi nuclear receptor NHR-67 0.0018 0.0022 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0022 0.0022
Giardia lamblia Kinase, PLK 0.0101 0.035 1
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0076 0.0779
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0076 0.0076
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.003 0.0039
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0022 0.0029
Mycobacterium tuberculosis Conserved protein 0.0185 0.0679 0.1439
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0139 0.027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0099 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0099 0.0129
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0099 0.0194
Leishmania major hypothetical protein, conserved 0.0185 0.0679 0.0884
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.003 0.0039
Schistosoma mansoni phd/f-box containing protein 0.003 0.0069 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0139 0.0712
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0099 0.0129
Brugia malayi nuclear receptor NHR-88 0.0037 0.0099 0.0129
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0014 0.001 0.005
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0099 0.0194
Schistosoma mansoni hypothetical protein 0.0046 0.0132 0.0257
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0028 0.0061 0.0542
Brugia malayi PHD-finger family protein 0.0031 0.0073 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0099 0.0129
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0154 0.0154
Echinococcus granulosus dnaJ subfamily B 0.0216 0.0797 0.1556
Mycobacterium ulcerans beta-lactamase 0.0185 0.0679 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0099 0.0129
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0115 0.059
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0029 0.0065 0.0084
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1972 0.7681 1
Brugia malayi conserved hypotetical protein 0.0018 0.0022 0.0029
Echinococcus multilocularis GPCR, family 2 0.0051 0.0154 0.0154
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0022 0.0022
Echinococcus multilocularis cyclin dependent kinase 5 0.0019 0.0026 0.0026
Echinococcus granulosus peregrin 0.0091 0.0311 0.0608
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0084
Schistosoma mansoni hypothetical protein 0.0337 0.1272 0.2482
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0022 0.0043
Brugia malayi Importin beta-1 subunit 0.0032 0.0076 0.01
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0337 0.1273 0.1273
Echinococcus multilocularis muscleblind protein 1 0.0299 0.1124 0.1124
Loa Loa (eye worm) G protein alpha subunit 3 0.0014 0.001 0.0013
Trichomonas vaginalis set domain proteins, putative 0.0509 0.1946 1
Brugia malayi RNA, U transporter 1 0.009 0.0304 0.0396
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0014 0.001 0.0013
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.0392 0.0765
Echinococcus granulosus neutral alpha glucosidase AB 0.0028 0.0061 0.0119
Mycobacterium tuberculosis Probable esterase LipL 0.0185 0.0679 0.1439
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.035 0.0455
Loa Loa (eye worm) hypothetical protein 0.0047 0.0139 0.018
Loa Loa (eye worm) hypothetical protein 0.0037 0.0099 0.0129
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0029 0.0065 0.0065
Echinococcus multilocularis cyclin dependent kinase 1 0.0019 0.0026 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.003 0.0019
Schistosoma mansoni nuclear receptor 0.0018 0.0022 0.0043
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0014 0.001 0.0019
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0019 0.0029 0.0038
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0099 0.0194
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.003 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.0679 0.3491
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.003 0.0069 0.0089
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0019 0.0026 0.0033
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0019 0.0026 0.0033
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.035 0.0455
Loa Loa (eye worm) hypothetical protein 0.0162 0.0588 0.0766
Toxoplasma gondii PHD-finger domain-containing protein 0.0091 0.0311 0.4372
Mycobacterium ulcerans hypothetical protein 0.0185 0.0679 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0185 0.0679 0.1439
Plasmodium falciparum transporter, putative 0.0029 0.0065 0.1369
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0029 0.0065 0.0126
Loa Loa (eye worm) hypothetical protein 0.0037 0.0099 0.0129
Echinococcus granulosus cyclin dependent kinase 1 0.0019 0.0026 0.005
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0107 0.0371 0.0371
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0022 0.0024
Leishmania major C-8 sterol isomerase-like protein 0.1972 0.7681 1
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0022 0.0043
Echinococcus granulosus lamin dm0 0.0031 0.0073 0.0143
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.035 0.1798
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0032 0.0078 0.0153
Plasmodium falciparum amino acid transporter, putative 0.0029 0.0065 0.1369
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0044 0.0057
Echinococcus granulosus p2X purinoceptor 4 0.009 0.0307 0.0599
Echinococcus granulosus GPCR family 2 0.0051 0.0154 0.0301
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0022 0.0043
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.001 0.005
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0044 0.028
Mycobacterium tuberculosis Conserved protein 0.0185 0.0679 0.1439
Brugia malayi jmjC domain containing protein 0.003 0.0069 0.0089
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0022 0.0029
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0019 0.0026 0.0033
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.003 0.0069 0.0134
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0099 0.0099
Brugia malayi jmjC domain containing protein 0.003 0.0069 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0099 0.0129
Echinococcus multilocularis Niemann Pick C1 protein 0.0158 0.0571 0.0571
Schistosoma mansoni intermediate filament proteins 0.0031 0.0073 0.0143
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0099 0.0194
Entamoeba histolytica hypothetical protein 0.0026 0.0053 0.1156
Echinococcus granulosus beta LACTamase domain containing family member 0.0185 0.0679 0.1325
Brugia malayi jmjC domain containing protein 0.03 0.1127 0.1467
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.003 0.0019
Schistosoma mansoni P2X receptor subunit 0.009 0.0307 0.0599
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0044 0.0564
Plasmodium vivax SET domain protein, putative 0.0064 0.0205 0.2748
Loa Loa (eye worm) hypothetical protein 0.0111 0.0387 0.0504
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1184 0.4593 1
Brugia malayi Pre-SET motif family protein 0.0064 0.0205 0.0267
Onchocerca volvulus 0.0018 0.0022 0.0024
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0099 0.0194
Brugia malayi nuclear hormone receptor 0.0018 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0088 0.0172
Mycobacterium ulcerans esterase/lipase LipP 0.0185 0.0679 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0205 0.04
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0017 0.0022
Brugia malayi nuclear receptor NHR-88 0.0018 0.0022 0.0029
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0099 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0337 0.1273 0.2485
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0069 0.0089
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0205 0.0205
Loa Loa (eye worm) norepinephrine transporter 0.0168 0.0611 0.0796
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0029 0.0065 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.003 0.0039
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.011 0.0385 1
Echinococcus multilocularis muscleblind protein 0.0299 0.1124 0.1124
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0014 0.001 0.0013
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0299 0.1124 0.1463
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0019 0.0026 0.005
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0099 0.0099
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0154 0.0201
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0091 0.0311 0.0608
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.003 0.0069 0.0659
Echinococcus granulosus jumonji domain containing 1A 0.003 0.0069 0.0134
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0014 0.001 0.0013
Echinococcus multilocularis phd:f box containing protein 0.003 0.0069 0.0069
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.003 0.0154
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0011
Onchocerca volvulus 0.0185 0.0679 0.1309
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.003 0.0039
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0099 0.0194
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.035 0.1798
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0014 0.001 0.0013
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0099 0.0175
Echinococcus multilocularis sodium and chloride dependent glycine 0.0029 0.0065 0.0065
Onchocerca volvulus 0.0029 0.0065 0.0108
Trichomonas vaginalis sucrase-isomaltase, putative 0.0028 0.0061 0.0313
Loa Loa (eye worm) hypothetical protein 0.0037 0.0099 0.0129
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0022 0.0043
Echinococcus multilocularis lysosomal alpha glucosidase 0.0124 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0185 0.0679 0.0884
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0205 0.2748
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0099 0.0099
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.035 0.1798
Echinococcus granulosus p2X purinoceptor 4 0.009 0.0307 0.0599
Echinococcus multilocularis dna polymerase kappa 0.002 0.003 0.003
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.003 0.007 0.0681
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0061 0.0079
Schistosoma mansoni hypothetical protein 0.0111 0.0387 0.0756
Schistosoma mansoni jumonji/arid domain-containing protein 0.0112 0.039 0.0761
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.035 0.035
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0029 0.0065 0.0126

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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