Detailed information for compound 787491

Basic information

Technical information
  • TDR Targets ID: 787491
  • Name: N-[2-(4-ethoxyphenyl)ethyl]-2-[[2-(3-methoxyp henyl)-5-methyl-1,3-oxazol-4-yl]methylsulfony l]acetamide
  • MW: 472.554 | Formula: C24H28N2O6S
  • H donors: 1 H acceptors: 4 LogP: 3.22 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)CCNC(=O)CS(=O)(=O)Cc1nc(oc1C)c1cccc(c1)OC
  • InChi: 1S/C24H28N2O6S/c1-4-31-20-10-8-18(9-11-20)12-13-25-23(27)16-33(28,29)15-22-17(2)32-24(26-22)19-6-5-7-21(14-19)30-3/h5-11,14H,4,12-13,15-16H2,1-3H3,(H,25,27)
  • InChiKey: QJIVVXRVOXUPGG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-ethoxyphenyl)ethyl]-2-[[2-(3-methoxyphenyl)-5-methyl-oxazol-4-yl]methylsulfonyl]acetamide
  • N-[2-(4-ethoxyphenyl)ethyl]-2-[[2-(3-methoxyphenyl)-5-methyl-4-oxazolyl]methylsulfonyl]acetamide
  • N-[2-(4-ethoxyphenyl)ethyl]-2-[[2-(3-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]methylsulfonyl]ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0012 0.0077
Plasmodium vivax sphingomyelin synthase 2, putative 0.0123 0.0484 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0116 0.0771
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0116 0.0771
Loa Loa (eye worm) hypothetical protein 0.0123 0.0484 0.0484
Brugia malayi jmjC domain containing protein 0.0062 0.0224 0.0224
Echinococcus granulosus intermediate filament protein 0.0027 0.0075 0.0495
Schistosoma mansoni hypothetical protein 0.0035 0.011 0.0731
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0075 0.0075
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0031 0.0417
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0123 0.0484 0.4052
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0011 0.0072
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0011 0.0011
Loa Loa (eye worm) histone methyltransferase 0.001 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0035 0.011 0.2097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1157 0.7679
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0045 0.0131
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0045 0.0045
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0123 0.0484 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0031 0.0031
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0809 0.3398 1
Onchocerca volvulus 0.0029 0.0082 0.0695
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0281 0.1157 0.3405
Brugia malayi transcription factor E74 isoform 0.0011 0.0006 0.0006
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0132 0.1156
Loa Loa (eye worm) hypothetical protein 0.004 0.0132 0.0132
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0123 0.0484 0.1425
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0045 0.0296
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0006 0.004
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0005 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0031 0.0204
Loa Loa (eye worm) hypothetical protein 0.015 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0132 0.0132
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0012 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0484 0.4052
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0045 0.0296
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.011 0.0731
Schistosoma mansoni thyroid hormone receptor 0.002 0.0045 0.0296
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0006 0.0018
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0006 0.0006
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0002 0.0013
Leishmania major hypothetical protein, conserved 0.0017 0.0031 0.0417
Schistosoma mansoni lamin 0.0027 0.0075 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0045 0.0045
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.0431 0.0431
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0045 0.0296
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Brugia malayi MH2 domain containing protein 0.001 0.0002 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0011 0.0072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0116 0.0771
Brugia malayi MH1 domain containing protein 0.001 0.0002 0.0002
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0003 0.0003
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0031 0.009
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0011 0.0011
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0211 0.1916
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0012 0.0077
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0031 0.0417
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0132 0.2555
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.1031 0.1031
Schistosoma mansoni smad1 5 8 and 0.001 0.0002 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0045 0.0045
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0211 0.4235
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0123 0.0484 1
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0012 0.0012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0109 0.0322
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0045 0.0296
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0211 0.1716
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0011 0.0072
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0109 0.0725
Schistosoma mansoni hypothetical protein 0.0076 0.0282 0.1874
Brugia malayi nuclear receptor NHR-88 0.002 0.0045 0.0045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0224 0.1487
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0211 0.4235
Loa Loa (eye worm) hypothetical protein 0.2362 1 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0082 0.0082
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0211 0.4235
Brugia malayi ecdysteroid receptor 0.002 0.0045 0.0045
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0012 0.0012 0.0012
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0132 0.0388
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0045 0.0045
Onchocerca volvulus 0.004 0.0132 0.1118
Mycobacterium tuberculosis Conserved protein 0.004 0.0132 0.1156
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0132 0.1035
Onchocerca volvulus 0.0012 0.0012 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0045 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0116 0.0771
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0123 0.0484 0.0484
Onchocerca volvulus 0.004 0.0132 0.1118
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0012 0.0077
Toxoplasma gondii exonuclease III APE 0.0059 0.0211 0.4235
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0282 0.0282
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0012 0.0006
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0012 0.0034
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0012 0.0012 0.0006
Echinococcus multilocularis musashi 0.0027 0.0075 0.0219
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0011 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1157 0.7679
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0011 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0045 0.0045
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0123 0.0484 0.0484
Entamoeba histolytica hypothetical protein 0.0123 0.0484 1
Onchocerca volvulus 0.0037 0.0116 0.0985
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.0431 0.0431
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0031 0.0204
Schistosoma mansoni elf1 0.0011 0.0006 0.004
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0011 0.0032
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0031 0.0204
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0012 0.0077
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0004 0.0023
Echinococcus multilocularis cpg binding protein 0.003 0.0089 0.0262
Schistosoma mansoni Smad4 0.001 0.0002 0.0013
Onchocerca volvulus 0.0012 0.0011 0.0093
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.011 0.0324
Echinococcus multilocularis Smad4 0.001 0.0002 0.0006
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0211 0.0211
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0031 0.0417
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.1157 0.7679
Plasmodium vivax hypothetical protein, conserved 0.004 0.0132 0.2555
Onchocerca volvulus 0.0027 0.0075 0.0632
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0276 0.1834
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0109 0.0109
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0123 0.0484 0.4052
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0031 0.0031
Echinococcus granulosus geminin 0.0364 0.1507 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0045 0.0296
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0109 0.0109
Entamoeba histolytica hypothetical protein 0.0035 0.011 0.2097
Brugia malayi Fli-1 protein 0.0226 0.092 0.092
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.1057 1
Brugia malayi hypothetical protein 0.0035 0.011 0.011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0045 0.0296
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0011 0.0032
Brugia malayi steroid hormone receptor 0.002 0.0045 0.0045
Onchocerca volvulus 0.0012 0.0012 0.0099
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0116 0.0771
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0012 0.0006
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0012 0.0012 0.0012
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0012 0.0012 0.0012
Schistosoma mansoni smad 0.001 0.0002 0.0013
Entamoeba histolytica hypothetical membrane-spanning protein 0.0123 0.0484 1
Loa Loa (eye worm) beta-lactamase 0.004 0.0132 0.0132
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0211 0.0211
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0012 0.0077
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0045 0.0296
Brugia malayi beta-lactamase family protein 0.004 0.0132 0.0132
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0132 0.1156
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0132 0.1156
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0012 0.0034
Onchocerca volvulus 0.002 0.0045 0.0378
Schistosoma mansoni hypothetical protein 0.0035 0.0109 0.0725
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0031 0.0204
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0281 0.1157 0.1157
Echinococcus multilocularis muscleblind protein 1 0.015 0.0596 0.1754
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0012 0.0077
Brugia malayi Ets-domain containing protein 0.0074 0.0276 0.0276
Echinococcus granulosus protein C ets 2 0.0011 0.0006 0.004
Brugia malayi MH1 domain containing protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.0031
Trichomonas vaginalis esterase, putative 0.004 0.0132 0.1035
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0045 0.0296
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0011 0.0072
Entamoeba histolytica G protein alpha subunit, putative 0.0012 0.0012 0.0015
Echinococcus multilocularis GPCR, family 2 0.0035 0.0109 0.0322
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0055 0.0055
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0035 0.011 0.2097
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0011 0.0011
Trichomonas vaginalis set domain proteins, putative 0.0287 0.1179 1
Brugia malayi hypothetical protein 0.0012 0.0012 0.0012
Mycobacterium leprae Probable lipase LipE 0.004 0.0132 0.5
Schistosoma mansoni hypothetical protein 0.0035 0.0109 0.0725
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0276 0.0276
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0123 0.0484 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0011 0.0011
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0123 0.0484 0.4052
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0116 0.0342
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0116 0.2223
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0006 0.004
Brugia malayi Pre-SET motif family protein 0.0037 0.0116 0.0116
Brugia malayi G-protein alpha subunit 0.0012 0.0012 0.0012
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0045 0.0378
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0045 0.0131
Schistosoma mansoni synaptojanin 0.0012 0.0011 0.0072
Mycobacterium leprae conserved hypothetical protein 0.004 0.0132 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0281 0.1157 0.7679
Plasmodium vivax SET domain protein, putative 0.0037 0.0116 0.2223
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0211 0.4235
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0123 0.0484 0.0484
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0224 0.066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Schistosoma mansoni ap endonuclease 0.0059 0.0211 0.1403
Toxoplasma gondii hypothetical protein 0.0123 0.0484 1
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0011 0.0072
Echinococcus multilocularis lamin 0.0027 0.0075 0.0219
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0006 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0045 0.0045
Toxoplasma gondii ABC1 family protein 0.004 0.0132 0.2555
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Echinococcus granulosus Smad4 0.001 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0109 0.0109
Entamoeba histolytica hypothetical protein 0.0123 0.0484 1
Echinococcus granulosus lamin dm0 0.0027 0.0075 0.0495
Echinococcus granulosus synaptojanin 1 0.0012 0.0011 0.0072
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0012 0.0012 0.0077
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0045 0.0296
Schistosoma mansoni coup transcription factor 0.002 0.0045 0.0296
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0109 0.0725
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0211 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0211 1
Schistosoma mansoni nocturnin 0.0012 0.0011 0.0072
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0045 0.0045
Schistosoma mansoni lamin 0.0027 0.0075 0.0495
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0006 0.0006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0132 0.0875
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0015 0.0045
Loa Loa (eye worm) hypothetical protein 0.0037 0.0116 0.0116
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0123 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0035 0.0109 0.0725
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0045 0.0296
Schistosoma mansoni intermediate filament proteins 0.0027 0.0075 0.0495
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0045 0.0131
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0012 0.0012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0109 0.0322
Schistosoma mansoni nuclear hormone receptor 0.002 0.0045 0.0296
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0005 0.0014
Echinococcus multilocularis muscleblind protein 0.015 0.0596 0.1754
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0012 0.0077
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0224 0.1489
Trypanosoma brucei inositol phosphorylceramide synthase 0.0123 0.0484 1
Schistosoma mansoni smad1 5 8 and 0.001 0.0002 0.0013
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0045 0.0131
Onchocerca volvulus 0.0012 0.0012 0.0099
Brugia malayi hypothetical protein 0.001 0.0005 0.0005
Schistosoma mansoni spingomyelin synthetase-related 0.0123 0.0484 0.3214
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0012 0.0012 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0045 0.0045
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0123 0.0484 0.0484
Brugia malayi hypothetical protein 0.001 0.0005 0.0005
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0012 0.0034
Brugia malayi jmjC domain containing protein 0.0017 0.0031 0.0031
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0012 0.0006
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0006 0.004
Onchocerca volvulus Putative neutral sphingomyelinase 0.0012 0.0011 0.0093
Onchocerca volvulus 0.0012 0.0011 0.0093
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0031 0.0417
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0364 0.1507 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0281 0.1157 0.7679
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0005 0.0032
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0012 0.0012 0.0012
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0011 0.0011
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0012 0.0077
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0006 0.004
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0045 0.0378
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0045 0.0045
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0031 0.0417
Echinococcus granulosus FTZ F1 alpha 0.002 0.0045 0.0296
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0006 0.004
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0012 0.0077
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.004 0.0132 0.0132
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0002 0.0006
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0006 0.004
Brugia malayi CCR4 0.0012 0.0011 0.0011
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.011 0.0731
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0123 0.0484 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0211 0.1403
Brugia malayi MH2 domain containing protein 0.0144 0.0573 0.0573
Plasmodium vivax sphingomyelin synthase 1, putative 0.0123 0.0484 1
Echinococcus multilocularis ets variant gene 4 0.0011 0.0006 0.0018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0045 0.0296
Echinococcus granulosus sphingomyelin synthase protein 1 0.0123 0.0484 0.3214
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0123 0.0484 1
Echinococcus multilocularis geminin 0.0364 0.1507 0.4435
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0281 0.1157 0.1157
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0045 0.0296
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0012 0.0077
Onchocerca volvulus 0.004 0.0132 0.1118
Schistosoma mansoni ets-related 0.0011 0.0006 0.004
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0027 0.0075 0.0075
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0123 0.0484 0.0484
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0012 0.0012 0.0012
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0031 0.009
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0045 0.0045
Echinococcus granulosus smad 0.001 0.0002 0.0013
Schistosoma mansoni cpg binding protein 0.003 0.0089 0.059
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0045 0.0131
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0109 0.0109
Echinococcus multilocularis protein C ets 2 0.0011 0.0006 0.0018
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0211 0.1716
Brugia malayi Ets-domain containing protein 0.0011 0.0006 0.0006
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0276 0.0814
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0082 0.0082
Brugia malayi MH2 domain containing protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0012 0.0012 0.0034
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0012 0.0012 0.0006
Schistosoma mansoni hypothetical protein 0.0364 0.1507 1
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0006 0.0018
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0075 0.0075
Brugia malayi jmjC domain containing protein 0.0017 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.0072
Entamoeba histolytica hypothetical protein 0.0035 0.011 0.2097
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0132 0.1156
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0123 0.0484 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0045 0.0045
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0196 0.3921
Schistosoma mansoni cpg binding protein 0.003 0.0089 0.059
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0045 0.0045
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0231 0.1535
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0231 0.0231
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0031 0.0204
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0011 0.0032
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0132 0.1156
Brugia malayi beta-lactamase family protein 0.004 0.0132 0.0132
Brugia malayi Pre-SET motif family protein 0.0252 0.1031 0.1031
Brugia malayi nuclear hormone receptor 0.002 0.0045 0.0045
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.0031
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0012 0.0012 0.0006
Echinococcus granulosus lamin 0.0027 0.0075 0.0495
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0123 0.0484 1
Brugia malayi Ets-domain containing protein 0.0074 0.0276 0.0276
Echinococcus granulosus GPCR family 2 0.0035 0.0109 0.0725
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0002 0.0013
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0012 0.0034
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.004 0.0132 0.0132
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0132 0.0875
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0006 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0132 0.1035
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0116 0.0342
Brugia malayi Cytochrome P450 family protein 0.0022 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.004
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0211 0.5
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0045 0.0045
Echinococcus granulosus muscleblind protein 0.015 0.0596 0.3955
Echinococcus multilocularis lamin dm0 0.0027 0.0075 0.0219
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0224 0.1489
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0011 0.0072
Brugia malayi Smad1 0.001 0.0002 0.0002
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0038 0.025
Loa Loa (eye worm) hypothetical protein 0.0123 0.0484 0.0484
Schistosoma mansoni smad1 5 8 and 0.001 0.0002 0.0013
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0012 0.0012 0.0006
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0002 0.0006
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0006 0.0006
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0123 0.0484 1
Schistosoma mansoni ap endonuclease 0.0059 0.0211 0.1403
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0108 0.0716
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0132 0.1035
Echinococcus granulosus cpg binding protein 0.003 0.0089 0.059
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.004 0.0132 0.0132
Brugia malayi Muscleblind-like protein 0.015 0.0596 0.0596
Entamoeba histolytica hypothetical protein 0.0123 0.0484 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Schistosoma mansoni cpg binding protein 0.0029 0.0082 0.0544
Loa Loa (eye worm) hypothetical protein 0.0111 0.0431 0.0431
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0075 0.0075
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0211 0.0622
Brugia malayi nuclear receptor RXR 0.001 0.0005 0.0005
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0211 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0231 0.0231
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0021 0.0021
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0045 0.0378
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0011 0.0032
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0012 0.0012 0.0077
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0224 0.066
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0231 0.1535
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0045 0.0045
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0012 0.0077
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0012 0.0077
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0211 0.4235
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0011 0.0011
Loa Loa (eye worm) Smad1 0.001 0.0002 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0281 0.1157 0.3405
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0132 0.2555
Schistosoma mansoni hypothetical protein 0.0012 0.0011 0.0072
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.0431 0.0431
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0123 0.0484 0.4052
Echinococcus granulosus expressed protein 0.0012 0.0012 0.0077
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0045 0.0131
Leishmania major hypothetical protein, conserved 0.004 0.0132 0.2555
Mycobacterium tuberculosis Conserved protein 0.004 0.0132 0.1156
Onchocerca volvulus 0.0287 0.1179 1
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0012 0.0012 0.0012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0005 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0132 0.1035
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0031 0.009
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.004
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0012 0.0077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0045 0.0131
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0012 0.0012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0045 0.0296
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0076 0.0282 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0045 0.0045
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0012 0.0012 0.0012
Echinococcus multilocularis smad 0.001 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Echinococcus granulosus phd:f box containing protein 0.0017 0.0031 0.0204
Schistosoma mansoni thyroid hormone receptor 0.002 0.0045 0.0296
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0015 0.0102
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0045 0.0296
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0031 0.0204
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0004 0.001
Brugia malayi intermediate filament protein 0.0027 0.0075 0.0075
Brugia malayi beta-lactamase 0.004 0.0132 0.0132
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0045 0.0296
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0132 0.1035
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0011 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0045 0.0045
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0006 0.0006
Mycobacterium tuberculosis Conserved protein 0.004 0.0132 0.1156
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0012 0.0077
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0132 0.0132
Schistosoma mansoni ets-related 0.0226 0.092 0.6107
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0012 0.0012 0.0012
Echinococcus multilocularis expressed protein 0.0012 0.0012 0.0034
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0012 0.0012 0.0012
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0006 0.0018
Echinococcus multilocularis synaptojanin 1 0.0012 0.0011 0.0032
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0011 0.0072
Loa Loa (eye worm) hypothetical protein 0.015 0.0596 0.0596
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0045 0.0296
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0123 0.0484 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0011 0.0011
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0012 0.0077
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0211 0.4235
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0045 0.0131
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.004 0.0132 0.0132
Loa Loa (eye worm) fli-1 protein 0.0226 0.092 0.092
Schistosoma mansoni cript-related 0.0012 0.0011 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0045 0.0045
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0005 0.0005
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0031 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0031 0.0417
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0132 0.1156
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0031 0.0204
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0038 0.0111
Entamoeba histolytica hypothetical protein 0.0123 0.0484 1
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0031 0.0204
Schistosoma mansoni ets 0.0011 0.0006 0.004
Plasmodium vivax JmjC domain containing protein 0.0017 0.0031 0.0417
Onchocerca volvulus 0.0027 0.0075 0.0632
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0132 0.2555
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0573 0.0573
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0132 0.0875
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0011 0.0011
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0123 0.0484 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0045 0.0131
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0006 0.0018
Brugia malayi jmjC domain containing protein 0.0017 0.0031 0.0031
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0005 0.0005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0132 0.0132
Brugia malayi Sphingomyelin synthase-related 1 0.0123 0.0484 0.0484
Brugia malayi jmjC domain containing protein 0.0064 0.0231 0.0231
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0021 0.0021
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0005 0.0005
Schistosoma mansoni gabp alpha 0.0074 0.0276 0.1834
Brugia malayi jmjC domain containing protein 0.0017 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0035 0.0109 0.0725
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0211 0.4235
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0132 0.1156
Loa Loa (eye worm) G protein alpha subunit 3 0.0012 0.0012 0.0012
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0123 0.0484 1
Schistosoma mansoni synaptojanin 0.0012 0.0011 0.0072
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0231 0.1535
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0002 0.0013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0045 0.0296
Trichomonas vaginalis hypothetical protein 0.0123 0.0484 0.4052
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0006 0.004
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0011 0.0011
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0011 0.0032
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.7783 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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