Detailed information for compound 866094

Basic information

Technical information
  • TDR Targets ID: 866094
  • Name: 4-[(2-methylphenyl)amino]-4-oxo-2-(pyridin-3- ylmethylamino)butanoic acid
  • MW: 313.351 | Formula: C17H19N3O3
  • H donors: 3 H acceptors: 4 LogP: -0.71 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1C)CC(C(=O)O)NCc1cccnc1
  • InChi: 1S/C17H19N3O3/c1-12-5-2-3-7-14(12)20-16(21)9-15(17(22)23)19-11-13-6-4-8-18-10-13/h2-8,10,15,19H,9,11H2,1H3,(H,20,21)(H,22,23)
  • InChiKey: KSUFHUZCNRCXKO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(2-methylphenyl)amino]-4-oxo-2-(3-pyridylmethylamino)butanoic acid
  • 4-keto-4-[(2-methylphenyl)amino]-2-(3-pyridylmethylamino)butyric acid
  • NCGC00100165-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0041 0.0274 0.0516
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.066 0.1281
Echinococcus granulosus Polycystic kidney disease protein 0.0038 0.0235 0.0457
Leishmania major DNA polymerase eta, putative 0.0038 0.0232 0.0778
Mycobacterium ulcerans hypothetical protein 0.0036 0.0205 0.1487
Plasmodium vivax heat shock protein, putative 0.0169 0.1934 1
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0026 0.0068 0.0063
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0205 0.0465
Schistosoma mansoni hypothetical protein 0.0096 0.0977 0.1841
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0105 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0088 0.0875 0.165
Echinococcus multilocularis geminin 0.0335 0.4086 0.4086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0116 0.0205
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.0105 0.0105
Brugia malayi TAR-binding protein 0.0076 0.073 0.1375
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0511 0.4362
Schistosoma mansoni nuclear receptor 0.0041 0.0274 0.0516
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0073 0.003
Echinococcus multilocularis Ankyrin 0.0029 0.0108 0.0108
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.2161 0.6211
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.026 0.0629
Mycobacterium tuberculosis Conserved protein 0.0036 0.0205 0.0591
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0204 0.0385
Loa Loa (eye worm) hypothetical protein 0.0088 0.0875 0.165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0088 0.0875 0.165
Schistosoma mansoni coup transcription factor 0.0088 0.0875 0.165
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1247 0.235
Echinococcus multilocularis adam 17 protease 0.0204 0.2383 0.2383
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0041 0.0274 0.0516
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0088 0.0875 0.17
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0187 0.2161 0.2161
Schistosoma mansoni endoplasmin 0.0045 0.0316 0.0596
Plasmodium vivax multidomain scavenger receptor, putative 0.0038 0.0235 0.0898
Brugia malayi Steroid receptor seven-up type 2 0.0088 0.0875 0.165
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0441 0.0831
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0108 0.0215
Brugia malayi nuclear hormone receptor family member nhr-6 0.0041 0.0274 0.0516
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0274 0.0274
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0511 0.0963
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0046 0.0338 0.0637
Plasmodium vivax endoplasmin, putative 0.0045 0.0316 0.1331
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0088 0.0875 0.165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0441 0.1159
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0232 0.0845
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0121 0.0386
Loa Loa (eye worm) hypothetical protein 0.0038 0.0235 0.0443
Trypanosoma brucei unspecified product 0.0026 0.0078 0.0204
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0316 0.1187
Echinococcus multilocularis thyroid hormone receptor alpha 0.0214 0.2514 0.2514
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0026 0.0068 0.0063
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0091 0.0916 0.3652
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0091 0.0916 0.1779
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.066 0.066
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0137 0.1521 0.1521
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0441 0.1657
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.003 0.0127 0.034
Giardia lamblia Kinase, PLK 0.0187 0.2161 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0088 0.0875 0.165
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1112 0.3971
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0116 0.0205
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0232 0.0845
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0441 0.1159
Schistosoma mansoni 60S ribosomal protein L19 0.0026 0.0068 0.0127
Brugia malayi Endoplasmin precursor 0.0045 0.0316 0.0596
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0516
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0516
Trypanosoma brucei heat shock protein, putative 0.0045 0.0316 0.1197
Loa Loa (eye worm) hypothetical protein 0.0036 0.0205 0.0386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0157 0.0326
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0232 0.0691
Echinococcus granulosus thyroid hormone receptor alpha 0.0041 0.0274 0.0531
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0205 0.0734
Schistosoma mansoni tar DNA-binding protein 0.0076 0.073 0.1375
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0205 0.0465
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0516
Echinococcus granulosus nuclear factor of activated T cells 5 0.0146 0.1627 0.3158
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0091 0.0916 0.8053
Loa Loa (eye worm) nuclear receptor NHR-67 0.0041 0.0274 0.0516
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0511 0.0511
Schistosoma mansoni tar DNA-binding protein 0.0076 0.073 0.1375
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0204 0.0385
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0088 0.0875 0.17
Mycobacterium ulcerans heat shock protein 90 0.0042 0.028 0.2198
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0026 0.0068 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.026 0.0629
Echinococcus multilocularis nuclear receptor nhr 48 0.0041 0.0274 0.0274
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0181
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0232 0.0436
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0205 0.0591
Loa Loa (eye worm) hypothetical protein 0.0046 0.0338 0.0637
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0041 0.0274 0.0516
Loa Loa (eye worm) matrix metalloproteinase 0.0067 0.0611 0.1152
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0088 0.0875 0.165
Loa Loa (eye worm) hypothetical protein 0.0088 0.0875 0.165
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0026 0.0068 0.0063
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0088 0.0875 0.0875
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0441 0.1657
Loa Loa (eye worm) acetyltransferase 0.0429 0.5307 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0088 0.0875 0.23
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0316 0.1187
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0316 0.1133
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1112 0.313
Loa Loa (eye worm) hypothetical protein 0.0088 0.0875 0.165
Loa Loa (eye worm) nuclear hormone receptor 0.0041 0.0274 0.0516
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0026 0.0068 0.0063
Brugia malayi nuclear receptor NHR-88 0.0088 0.0875 0.165
Loa Loa (eye worm) steroid hormone receptor 0.0088 0.0875 0.165
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0128 0.1397 0.2712
Echinococcus granulosus geminin 0.0335 0.4086 0.7934
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0041 0.0274 0.0516
Schistosoma mansoni endoplasmin 0.0045 0.0316 0.0596
Onchocerca volvulus Bile acid receptor homolog 0.0088 0.0875 0.23
Brugia malayi nuclear receptor RXR 0.0046 0.0338 0.0637
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.028 0.5
Plasmodium falciparum endoplasmin, putative 0.0032 0.0157 0.0479
Brugia malayi Death domain containing protein 0.0028 0.0105 0.0198
Schistosoma mansoni rab6-interacting 0.0038 0.0235 0.0443
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0235 0.0457
Echinococcus granulosus netrin receptor unc 5 0.0028 0.0105 0.0204
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0128 0.1397 0.1397
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0205 0.0665
Echinococcus granulosus adam 0.0035 0.0196 0.0381
Loa Loa (eye worm) hypothetical protein 0.0088 0.0875 0.165
Schistosoma mansoni steroid hormone receptor ad4bp 0.0088 0.0875 0.165
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.026 0.0629
Echinococcus multilocularis ribosomal protein L19 0.0026 0.0068 0.0068
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0511 0.0992
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0088 0.0875 0.165
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0232 0.0787
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1112 0.1112
Leishmania major 60S ribosomal protein L19, putative 0.0026 0.0068 0.009
Brugia malayi hypothetical protein 0.0198 0.2306 0.4345
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1112 0.2095
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0274 0.0531
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0204 0.0732
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0088 0.0875 0.165
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0252 0.3009 0.3009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0088 0.0875 0.165
Brugia malayi hypothetical protein 0.0038 0.0235 0.0443
Loa Loa (eye worm) beta-lactamase 0.0036 0.0205 0.0386
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.2161 0.8876
Loa Loa (eye worm) hypothetical protein 0.0088 0.0875 0.165
Echinococcus multilocularis adam 0.0035 0.0196 0.0196
Brugia malayi Pre-SET motif family protein 0.0036 0.0204 0.0385
Schistosoma mansoni jun-related protein 0.0205 0.2396 0.4514
Loa Loa (eye worm) hypothetical protein 0.0046 0.0338 0.0637
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0088 0.0875 0.17
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0316 0.1197
Onchocerca volvulus 0.0038 0.0235 0.0388
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0204 0.0385
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0205 0.0386
Loa Loa (eye worm) hypothetical protein 0.0036 0.0205 0.0386
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1112 0.4513
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0274 0.0516
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0338 0.0637
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0205 0.0205
Brugia malayi Hsp90 protein 0.003 0.0121 0.0229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0157 0.0326
Entamoeba histolytica serine/threonine protein kinase, putative 0.0187 0.2161 1
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0091 0.0916 0.1727
Brugia malayi conserved hypotetical protein 0.0041 0.0274 0.0516
Giardia lamblia Grp94/Hsp90 0.0042 0.028 0.1017
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0028 0.0105 0.0105
Schistosoma mansoni heat shock protein 0.003 0.0121 0.0229
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0181
Echinococcus granulosus histone acetyltransferase KAT2B 0.0417 0.515 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0205 0.0386
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0516
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.026 0.1033
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0516
Plasmodium falciparum heat shock protein 90 0.0045 0.0316 0.1331
Trichomonas vaginalis heat shock protein, putative 0.0042 0.028 0.0688
Echinococcus multilocularis RUN 0.0038 0.0235 0.0235
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.2161 0.6211
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0204 0.0397
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0026 0.0068 0.009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0232 0.0778
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.066 0.1243
Brugia malayi MH2 domain containing protein 0.0116 0.1247 0.235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0088 0.0875 0.165
Loa Loa (eye worm) TAR-binding protein 0.0076 0.073 0.1375
Loa Loa (eye worm) hypothetical protein 0.0038 0.0232 0.0436
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0516
Treponema pallidum heat shock protein 90 0.0042 0.028 0.1719
Schistosoma mansoni hypothetical protein 0.0071 0.066 0.1243
Schistosoma mansoni retinoic acid receptor RXR 0.0184 0.2123 0.4001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0088 0.0875 0.165
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0105 0.0198
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0091 0.0916 0.3698
Brugia malayi RNA binding protein 0.0076 0.073 0.1375
Brugia malayi orphan nuclear receptor NR2E1 0.0041 0.0274 0.0516
Echinococcus granulosus jun protein 0.0252 0.3009 0.5842
Brugia malayi acetyltransferase, GNAT family protein 0.0429 0.5307 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0232 0.0845
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.2161 0.6211
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.2429 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0205 0.1487
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1112 1
Leishmania major 60S ribosomal protein L19, putative 0.0026 0.0068 0.009
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0205 0.0591
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0088 0.0875 0.165
Plasmodium falciparum heat shock protein 90, putative 0.0169 0.1934 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0274 0.0503
Onchocerca volvulus 0.0038 0.0235 0.0388
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0441 0.0856
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0099 0.1022 0.511
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0232 0.0436
Brugia malayi hypothetical protein 0.0046 0.0338 0.0637
Brugia malayi 60S ribosomal protein L19 0.0026 0.0068 0.0127
Onchocerca volvulus 0.0036 0.0205 0.0297
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0205 0.0591
Onchocerca volvulus 0.0096 0.0977 0.2602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0297 0.0736
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0088 0.0875 0.165
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.2429 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0441 0.1717
Echinococcus multilocularis tar DNA binding protein 0.0076 0.073 0.073
Loa Loa (eye worm) hypothetical protein 0.0428 0.5298 0.9984
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0181
Trypanosoma brucei heat shock protein, putative 0.0045 0.0316 0.1197
Trichomonas vaginalis bromodomain-containing protein, putative 0.0126 0.1374 0.39
Brugia malayi photoreceptor-specific nuclear receptor 0.0088 0.0875 0.165
Brugia malayi phosphofructokinase 0.0106 0.1112 0.2095
Loa Loa (eye worm) hypothetical protein 0.0088 0.0875 0.165
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0232 0.0436
Onchocerca volvulus 0.0067 0.0611 0.151
Mycobacterium ulcerans ammonium-transport integral membrane protein, Amt 0.0043 0.03 0.2386
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0232 0.0845
Brugia malayi hypothetical protein 0.0038 0.0235 0.0443
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0232 0.0845
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0274 0.0516
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0046 0.0338 0.0637
Entamoeba histolytica acetyltransferase, GNAT family 0.0116 0.1238 0.5589
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.028 0.0873
Echinococcus granulosus dna polymerase eta 0.0038 0.0232 0.045
Schistosoma mansoni tar DNA-binding protein 0.0076 0.073 0.1375
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0232 0.0436
Brugia malayi Uncoordinated protein 44 0.0028 0.0105 0.0198
Loa Loa (eye worm) hypothetical protein 0.0067 0.0611 0.1152
Onchocerca volvulus 0.0088 0.0875 0.23
Echinococcus multilocularis heat shock protein 90 0.0038 0.0232 0.0232
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.028 0.0983
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0088 0.0875 0.165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0116 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0078 0.0204
Brugia malayi 6-phosphofructokinase 0.0106 0.1112 0.2095
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.026 0.0629
Echinococcus granulosus ribosomal protein L19 0.0026 0.0068 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0297 0.0736
Loa Loa (eye worm) hypothetical protein 0.0036 0.0205 0.0386
Brugia malayi Protein kinase domain containing protein 0.0029 0.0113 0.0213
Plasmodium falciparum histone acetyltransferase GCN5 0.0116 0.1238 0.6269
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0441 0.1657
Loa Loa (eye worm) DR-78 0.0041 0.0274 0.0516
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0441 0.0831
Trypanosoma brucei unspecified product 0.0038 0.0232 0.0845
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0082 0.0802 0.1511
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1112 0.4473
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.2161 0.4073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0194 0.0433
Brugia malayi hypothetical protein 0.0041 0.0274 0.0516
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0091 0.0916 0.0916
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0441 0.1657
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1112 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0297 0.1054
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0088 0.0875 0.165
Entamoeba histolytica hypothetical protein 0.0071 0.066 0.2828
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0937 0.2615
Trypanosoma brucei heat shock protein, putative 0.0045 0.0316 0.1197
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.0204
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0232 0.0544
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0232 0.0845
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0078 0.0204
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0205 0.0665
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0121 0.0121
Brugia malayi beta-lactamase family protein 0.0036 0.0205 0.0386
Onchocerca volvulus Matrilysin homolog 0.0067 0.0611 0.151
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0108 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0088 0.0875 0.165
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Schistosoma mansoni hypothetical protein 0.0335 0.4086 0.77
Loa Loa (eye worm) hypothetical protein 0.0036 0.0204 0.0385
Brugia malayi glucose-6-phosphate dehydrogenase 0.0091 0.0916 0.1727
Loa Loa (eye worm) hypothetical protein 0.0036 0.0205 0.0386
Echinococcus multilocularis ribosomal protein L19 0.0026 0.0068 0.0068
Onchocerca volvulus Matrilysin homolog 0.0149 0.1677 0.4692
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0059 0.0507 0.2354
Brugia malayi nuclear receptor NHR-88 0.0041 0.0274 0.0516
Schistosoma mansoni hypothetical protein 0.0335 0.4086 0.77
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0088 0.0875 0.165
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0029 0.0108 0.0204
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0096 0.0986 0.1858
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0204 0.0204
Echinococcus multilocularis Polycystic kidney disease protein 0.0038 0.0235 0.0235
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0099 0.1022 0.4556
Brugia malayi Matrixin family protein 0.0067 0.0611 0.1152
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0441 0.0441
Echinococcus granulosus death domain containing protein 0.0028 0.0105 0.0204
Brugia malayi Ammonium transporter 3 0.0043 0.03 0.0566
Schistosoma mansoni netrin receptor unc5 0.0028 0.0105 0.0198
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.2668 0.5027
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0516
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.273 1
Schistosoma mansoni ankyrin 23/unc44 0.0028 0.0105 0.0198
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0316 0.1331
Brugia malayi hypothetical protein 0.0035 0.0196 0.037
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0026 0.0068 0.009
Schistosoma mansoni hypothetical protein 0.0126 0.1375 0.259
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.2161 0.6211
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0232 0.0778
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0046 0.0338 0.0656
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0121 0.0236
Onchocerca volvulus Matrix metalloproteinase homolog 0.0149 0.1677 0.4692
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0091 0.0916 0.3652
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0073 0.0079
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0088 0.0875 0.0875
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0108 0.0215
Loa Loa (eye worm) hypothetical protein 0.0032 0.0146 0.0275
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0205 0.0397
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0126 0.1374 0.7
Trypanosoma brucei polo-like protein kinase 0.0187 0.2161 0.8884
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0232 0.0845
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0059 0.0507 0.4324
Brugia malayi nuclear receptor NHR-67 0.0041 0.0274 0.0516
Brugia malayi Matrixin family protein 0.0163 0.1852 0.3489
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0082 0.0802 0.2815
Plasmodium vivax heat shock protein 90, putative 0.003 0.0121 0.0288
Leishmania major DNA polymerase kappa, putative 0.0038 0.0232 0.0778
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0316 0.1197
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0187 0.2161 0.4196
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0338 0.0637
Onchocerca volvulus 0.0036 0.0204 0.0296
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0232 0.0845
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0099 0.1022 0.511
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0429 0.5307 1
Schistosoma mansoni lipoxygenase 0.0169 0.1928 0.3633
Leishmania major hypothetical protein, conserved 0.0036 0.0205 0.0665
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0205 0.0465
Trypanosoma brucei unspecified product 0.0026 0.0078 0.0204
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0235 0.0457
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0232 0.0845
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3451 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0875 0.165
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Echinococcus granulosus tar DNA binding protein 0.0076 0.073 0.1417
Echinococcus granulosus heat shock protein 90 0.0045 0.0316 0.0614
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1112 0.4988
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0316 0.0596
Onchocerca volvulus 0.0041 0.0274 0.0503
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0232 0.0778
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0232 0.0781
Brugia malayi nuclear receptor RXR 0.0041 0.0274 0.0516
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0232 0.1739
Brugia malayi hypothetical protein 0.0147 0.1649 0.3107
Echinococcus granulosus dna polymerase kappa 0.0038 0.0232 0.045
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0232 0.0436
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0413 0.0779
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0088 0.0875 0.0875
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0046 0.033 0.0622
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1112 0.2095
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.2161 0.6211
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0028 0.0105 0.0204
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0316 0.1133
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0099 0.1022 0.2864
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0099 0.1022 0.2864
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0041 0.0274 0.0531
Brugia malayi Matrixin family protein 0.0067 0.0611 0.1152
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1112 0.313
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1247 0.235
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0205 0.0386
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0088 0.0875 0.165
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1112 0.2095
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0429 0.5307 0.5307
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0108 0.0215
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0205 0.0733
Echinococcus multilocularis ecdysone induced protein 78C 0.0088 0.0875 0.0875
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1112 0.4473
Schistosoma mansoni heat shock protein 0.0045 0.0316 0.0596
Plasmodium vivax SET domain protein, putative 0.0036 0.0204 0.0732
Loa Loa (eye worm) hypothetical protein 0.0046 0.0338 0.0637
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0205 0.0591
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0026 0.0068 0.0161
Echinococcus multilocularis heat shock protein 90 0.0045 0.0316 0.0316
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0046 0.009
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0245 0.2917 0.5664
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0099 0.1022 0.2864
Loa Loa (eye worm) hypothetical protein 0.0036 0.0205 0.0386
Schistosoma mansoni polycystin 1-related 0.0038 0.0235 0.0443
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0232 0.0451
Schistosoma mansoni nuclear hormone receptor 0.0088 0.0875 0.165
Onchocerca volvulus 0.0036 0.0205 0.0297
Loa Loa (eye worm) hypothetical protein 0.0147 0.1649 0.3107
Schistosoma mansoni hypothetical protein 0.0205 0.2396 0.4514
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0187 0.2161 0.8876
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0205 0.0591
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.073 0.1375
Echinococcus multilocularis jun protein 0.0252 0.3009 0.3009
Trypanosoma cruzi ammonium transporter, putative 0.0043 0.03 0.1067
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.026 0.0629
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0516
Brugia malayi Doublecortin family protein 0.0038 0.0235 0.0443
Mycobacterium ulcerans beta-lactamase 0.0036 0.0205 0.1487
Mycobacterium tuberculosis Conserved protein 0.0036 0.0205 0.0591
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1112 1
Onchocerca volvulus 0.0198 0.2306 0.6571
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0121 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0274 0.0274
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0088 0.0875 0.165
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0205 0.0465
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0516
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.3 0.5654
Loa Loa (eye worm) hypothetical protein 0.0245 0.2919 0.5501
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0121 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0117 0.0207
Echinococcus granulosus histone acetyltransferase KAT2B 0.0126 0.1374 0.2668
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.2161 0.6211
Loa Loa (eye worm) hypothetical protein 0.0082 0.0802 0.1511
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0088 0.0875 0.165
Brugia malayi bZIP transcription factor family protein 0.0252 0.3009 0.567
Giardia lamblia DINP protein human, muc B family 0.0038 0.0232 0.0783
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0232 0.0783
Brugia malayi steroid hormone receptor 0.0088 0.0875 0.165
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.026 0.0629
Loa Loa (eye worm) hypothetical protein 0.0026 0.0068 0.0127
Schistosoma mansoni loxhd1 0.0038 0.0235 0.0443
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.0875 0.0875
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0088 0.0875 0.0875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0117 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0297 0.0736
Schistosoma mansoni tar DNA-binding protein 0.0076 0.073 0.1375
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0316 0.1331
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0121 0.0257
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0274 0.0274
Brugia malayi beta-lactamase family protein 0.0036 0.0205 0.0386
Onchocerca volvulus 0.0286 0.3454 1
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0316 0.1331
Brugia malayi follicle stimulating hormone receptor 0.0226 0.2668 0.5027
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0511 0.4362
Schistosoma mansoni kinase 0.0095 0.0969 0.1825
Echinococcus granulosus endoplasmin 0.0042 0.028 0.0545
Brugia malayi Nuclear hormone receptor-like 1 0.0088 0.0875 0.165
Loa Loa (eye worm) hypothetical protein 0.0046 0.0338 0.0637
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1112 0.313
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0187 0.2161 0.4073
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0232 0.1739
Schistosoma mansoni RAR-like nuclear receptor 0.0088 0.0875 0.165
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0046 0.0046
Echinococcus granulosus heat shock protein 90 0.0038 0.0232 0.0451
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0274 0.0516
Toxoplasma gondii Hsp90 domain-containing protein 0.0169 0.1934 1
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1112 0.2095
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0205 0.0591
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0108 0.0192
Brugia malayi Matrixin family protein 0.0067 0.0611 0.1152
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0041 0.0274 0.0274
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0091 0.0916 0.8165
Onchocerca volvulus Protein ultraspiracle homolog 0.0088 0.0875 0.23
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0297 0.0736
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0511 0.1732
Onchocerca volvulus 0.0036 0.0205 0.0297
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0316 0.0793
Brugia malayi serine/threonine-protein kinase plk-2 0.0187 0.2161 0.4073
Brugia malayi hypothetical protein 0.0041 0.0274 0.0516
Mycobacterium leprae PROBABLE HYDROLASE 0.0082 0.0802 0.6581
Plasmodium falciparum LCCL domain-containing protein 0.0038 0.0235 0.0898
Leishmania major hypothetical protein, conserved 0.0207 0.2429 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0088 0.0875 0.165
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0096 0.0986 0.1915
Trichomonas vaginalis endoplasmin, putative 0.0032 0.0157 0.0326
Brugia malayi ecdysteroid receptor 0.0088 0.0875 0.165
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0067 0.0611 0.1152
Schistosoma mansoni nuclear receptor 0.0041 0.0274 0.0516
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0297 0.1054
Echinococcus multilocularis FTZ F1 alpha 0.0088 0.0875 0.0875
Brugia malayi 6-phosphofructokinase 0.0106 0.1112 0.2095
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0046 0.0338 0.0338
Brugia malayi ecdysone receptor 0.0041 0.0274 0.0516
Mycobacterium ulcerans hydrolase 0.0082 0.0802 0.7089
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.028 0.0835
Loa Loa (eye worm) hypothetical protein 0.0088 0.0875 0.165
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0205 0.0591
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0232 0.0845
Schistosoma mansoni DNA polymerase eta 0.0038 0.0232 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0153 0.0314
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0297 0.1119
Echinococcus granulosus nuclear receptor nhr 48 0.0041 0.0274 0.0531
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0232 0.0845
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0252 0.3009 0.5842
Brugia malayi beta-lactamase 0.0036 0.0205 0.0386
Loa Loa (eye worm) endoplasmin 0.0045 0.0316 0.0596
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0441 0.1783
Trypanosoma cruzi heat shock protein, putative 0.003 0.0121 0.0316
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0069 0.0169
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0029 0.0116 0.0292
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0108 0.0215
Onchocerca volvulus 0.0041 0.0274 0.0503
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0516
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.2161 0.6211
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0108 0.0192
Schistosoma mansoni tar DNA-binding protein 0.0076 0.073 0.1375
Schistosoma mansoni hypothetical protein 0.0038 0.0235 0.0443
Trypanosoma brucei heat shock protein, putative 0.0045 0.0316 0.1197
Loa Loa (eye worm) hypothetical protein 0.0028 0.0105 0.0198
Loa Loa (eye worm) hypothetical protein 0.0036 0.0205 0.0386
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0184 0.2123 0.4123
Echinococcus granulosus adam 17 protease 0.0224 0.2647 0.5139
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0511 0.1951
Brugia malayi heat shock protein 90 0.0045 0.0316 0.0596
Entamoeba histolytica hypothetical protein 0.0071 0.066 0.2828
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0232 0.0845
Loa Loa (eye worm) heat shock protein 75 0.003 0.0121 0.0229
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0232 0.0544
Entamoeba histolytica hypothetical protein 0.0071 0.066 0.2828
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.2161 0.8876
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0026 0.0068 0.0161
Loa Loa (eye worm) matrixin family protein 0.0163 0.1852 0.3489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0209 0.0478
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0232 0.0778
Schistosoma mansoni nuclear receptor nhr-48 0.0041 0.0274 0.0516
Echinococcus granulosus heat shock protein 0.0045 0.0316 0.0614
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0511 0.0963
Loa Loa (eye worm) hypothetical protein 0.0067 0.0611 0.1152
Leishmania major heat shock protein, putative 0.003 0.0121 0.0316
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0232 0.0778
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0441 0.1717
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0126 0.1374 0.7
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0204 0.0385
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.1375 0.2669
Echinococcus multilocularis heat shock protein 0.0045 0.0316 0.0316
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.0875 0.17
Brugia malayi Pre-SET motif family protein 0.0251 0.3 0.5654
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0441 0.1783
Giardia lamblia GTOR 0.0054 0.0441 0.1783
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.0875 0.0875
Echinococcus granulosus FTZ F1 alpha 0.0088 0.0875 0.17
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1112 0.2095
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0187 0.0363
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0235 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0088 0.0875 0.165
Schistosoma mansoni hypothetical protein 0.0028 0.0105 0.0198
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0516
Echinococcus multilocularis dna polymerase eta 0.0038 0.0232 0.0232
Trypanosoma brucei heat shock protein, putative 0.0045 0.0316 0.1197
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0274 0.0516
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0232 0.0778
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0157 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0117 0.0207
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0232 0.0781
Echinococcus granulosus ecdysone induced protein 78C 0.0088 0.0875 0.17
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0205 0.0386
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0516
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0204 0.2383 0.4491
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0232 0.0547
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0088 0.0875 0.165
Mycobacterium tuberculosis Conserved protein 0.0036 0.0205 0.0591
Schistosoma mansoni thyroid hormone receptor 0.0214 0.2514 0.4737
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0205 0.0465
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1112 0.2159
Loa Loa (eye worm) RNA binding protein 0.0076 0.073 0.1375
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0091 0.0916 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0088 0.0875 0.165
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0205 0.1487
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0088 0.0875 0.165
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0096 0.0986 0.0986
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0274 0.0531
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0126 0.1374 0.7
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0169 0.1928 0.1928
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0232 0.0845
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0235 0.0235
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Giardia lamblia Histone acetyltransferase GCN5 0.0116 0.1238 0.5589
Trichomonas vaginalis heat shock protein, putative 0.0042 0.028 0.0688
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0035 0.0196 0.037
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0126 0.1374 0.39
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1112 0.313
Trypanosoma brucei heat shock protein, putative 0.0045 0.0316 0.1197
Onchocerca volvulus 0.0147 0.1649 0.4609
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0088 0.0875 0.17
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0099 0.1022 0.511
Schistosoma mansoni thyroid hormone receptor 0.0214 0.2514 0.4737
Brugia malayi nuclear hormone receptor 0.0088 0.0875 0.165
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Mycobacterium ulcerans lipase LipD 0.0036 0.0205 0.1487
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0032 0.0146 0.037
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0232 0.045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0088 0.0875 0.165
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0169 0.1928 0.3743
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0338 0.0637
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0108 0.0215
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.0875 0.17
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0232 0.0232
Toxoplasma gondii ABC1 family protein 0.0036 0.0205 0.0734
Brugia malayi hypothetical protein 0.0046 0.0338 0.0637
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0316 0.1133
Loa Loa (eye worm) hypothetical protein 0.0046 0.0338 0.0637
Echinococcus granulosus ribosomal protein L19 0.0026 0.0068 0.0131
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0516
Loa Loa (eye worm) hypothetical protein 0.0067 0.0611 0.1152
Entamoeba histolytica hypothetical protein 0.0071 0.066 0.2828
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0146 0.1627 0.1627
Brugia malayi tailless protein 0.0041 0.0274 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0441 0.1159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0297 0.0736
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0232 0.0845
Loa Loa (eye worm) hypothetical protein 0.0038 0.0235 0.0443
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0316 0.1187
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0937 0.2615
Onchocerca volvulus Serine\/threonine kinase homolog 0.0187 0.2161 0.6138
Brugia malayi nuclear hormone receptor family member odr-7 0.0041 0.0274 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0117 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0338 0.0857
Mycobacterium tuberculosis Probable ammonium-transport integral membrane protein Amt 0.0032 0.0146 0.0371
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Trypanosoma brucei heat shock protein, putative 0.0045 0.0316 0.1197
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0274 0.0531
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0316 0.1197
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0181
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0245 0.2917 0.2917
Loa Loa (eye worm) ammonium transporter 3 0.0043 0.03 0.0566
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.073 0.1375
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0181
Brugia malayi Matrixin family protein 0.0067 0.0611 0.1152
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1112 0.4988
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0157 0.0326
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0026 0.0068 0.009
Loa Loa (eye worm) matrixin family protein 0.0149 0.1677 0.316
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0204 0.0204
Echinococcus multilocularis endoplasmin 0.0042 0.028 0.028
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0108 0.0215
Loa Loa (eye worm) doublecortin family protein 0.0038 0.0235 0.0443
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0274 0.0503
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Brugia malayi Hemopexin family protein 0.0096 0.0977 0.1841
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0088 0.0875 0.165
Brugia malayi nuclear hormone receptor 0.0041 0.0274 0.0516
Schistosoma mansoni rab6-interacting 0.0038 0.0235 0.0443
Trypanosoma cruzi ammonium transporter, putative 0.0043 0.03 0.1067
Echinococcus granulosus RUN 0.0038 0.0235 0.0457
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0441 0.0831
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.026 0.0629
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0108 0.0181
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0316 0.1133
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0078 0.0204
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1112 0.4988
Schistosoma mansoni zinc finger protein 0.0041 0.0274 0.0516
Brugia malayi hypothetical protein 0.0071 0.066 0.1243
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0108 0.0181
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0316 0.1133
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.1375 0.1375
Trichomonas vaginalis esterase, putative 0.0036 0.0205 0.0465
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0232 0.0232
Trypanosoma brucei heat shock protein, putative 0.0045 0.0316 0.1197
Echinococcus granulosus Ankyrin 0.0029 0.0108 0.021
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0096 0.0986 0.1858
Schistosoma mansoni heat shock protein 0.0045 0.0316 0.0596
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0232 0.0691
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0091 0.0916 0.1727
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.2429 1
Schistosoma mansoni lipoxygenase 0.01 0.1029 0.194
Leishmania major heat shock protein 83-1 0.0045 0.0316 0.1133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0153 0.0314

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.2119 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.1216 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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