TDR Targets

Basic information

Technical information

TDR Targets ID: 880853
Name: N-(4,6-dimethylpyridin-2-yl)-4-methoxybenzene sulfonamide
MW: 292.353 | Formula: C14H16N2O3S
H donors: 1 H acceptors: 3 LogP: 2.44 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)S(=O)(=O)Nc1cc(C)cc(n1)C
InChi: 1S/C14H16N2O3S/c1-10-8-11(2)15-14(9-10)16-20(17,18)13-6-4-12(19-3)5-7-13/h4-9H,1-3H3,(H,15,16)
InChiKey: GZOLZLFAGJKNNQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4,6-dimethyl-2-pyridyl)-4-methoxy-benzenesulfonamide
N-(4,6-dimethyl-2-pyridyl)-4-methoxybenzenesulfonamide
N-(4,6-dimethylpyridin-2-yl)-4-methoxy-benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	oxidoreductase, putative	0.011	0.0152	1
Brugia malayi	dehydrogenases, short chain protein 2	0.011	0.0152	0.0473
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.0152	0.1215
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	1
Schistosoma mansoni	histone deacetylase hda2	0.0047	0.0054	0.2428
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.011	0.0152	0.6724
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.011	0.0152	1
Echinococcus granulosus	histone deacetylase 7	0.004	0.0044	0.1949
Loa Loa (eye worm)	oxidoreductase	0.011	0.0152	0.0473
Echinococcus granulosus	histone deacetylase 6	0.004	0.0044	0.1949
Loa Loa (eye worm)	oxidoreductase	0.011	0.0152	0.0473
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Brugia malayi	Dehydrogenases, short chain protein 30	0.011	0.0152	0.0473
Schistosoma mansoni	carbonyl reductase	0.011	0.0152	0.6884
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.011	0.0152	0.6724
Leishmania major	short chain dehydrogenase, putative	0.011	0.0152	0.1215
Leishmania major	short chain dehydrogenase/reductase, putative	0.011	0.0152	0.1215
Loa Loa (eye worm)	hypothetical protein	0.011	0.0152	0.0473
Loa Loa (eye worm)	hypothetical protein	0.011	0.0152	0.0473
Schistosoma mansoni	steroid dehydrogenase	0.011	0.0152	0.6884
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.0152	0.1215
Schistosoma mansoni	steroid dehydrogenase	0.011	0.0152	0.6884
Mycobacterium ulcerans	short chain dehydrogenase	0.6452	1	1
Giardia lamblia	Short-chain dehydrogenase, putative	0.011	0.0152	1
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.011	0.0152	0.6884
Trypanosoma cruzi	histone deacetylase, putative	0.004	0.0044	0.0352
Echinococcus multilocularis	histone deacetylase 6	0.004	0.0044	0.1946
Leishmania major	malonyl-coa decarboxylase-like protein	0.0816	0.1248	1
Schistosoma mansoni	carbonyl reductase	0.011	0.0152	0.6884
Schistosoma mansoni	retinal dehydrogenase	0.011	0.0152	0.6884
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.011	0.0152	0.6724
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.011	0.0152	0.1215
Loa Loa (eye worm)	hypothetical protein	0.011	0.0152	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0035	0.0108
Echinococcus multilocularis	histone deacetylase 6	0.004	0.0044	0.1946
Leishmania major	hypothetical protein, conserved	0.011	0.0152	0.1215
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.011	0.0152	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0152	0.0473
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.011	0.0152	0.6735
Echinococcus granulosus	retinol dehydrogenase 11	0.011	0.0152	0.6735
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.011	0.0152	0.1215
Leishmania major	hypothetical protein, conserved	0.011	0.0152	0.1215
Brugia malayi	hypothetical protein	0.011	0.0152	0.0473
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.011	0.0152	0.5
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.011	0.0152	0.0473
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Mycobacterium leprae	Probable oxidoreductase	0.011	0.0152	0.5
Onchocerca volvulus		0.011	0.0152	1
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.011	0.0152	0.1215
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Echinococcus granulosus	steroid dehydrogenase	0.011	0.0152	0.6735
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.011	0.0152	0.1215
Brugia malayi	hypothetical protein	0.011	0.0152	0.0473
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.011	0.0152	1
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.011	0.0152	0.1215
Trypanosoma brucei	short-chain dehydrogenase, putative	0.011	0.0152	0.1215
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.011	0.0152	0.1215
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.011	0.0152	0.0473
Loa Loa (eye worm)	oxidoreductase	0.011	0.0152	0.0473
Echinococcus granulosus	carbonyl reductase 1	0.011	0.0152	0.6735
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.011	0.0152	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.011	0.0152	1
Echinococcus granulosus	hypothetical protein	0.011	0.0152	0.6735
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.011	0.0152	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.011	0.0152	1
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.011	0.0152	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0152	0.0473
Onchocerca volvulus	Sepiapterin reductase homolog	0.011	0.0152	1
Leishmania major	quinonoid dihydropteridine reductase	0.011	0.0152	0.1215
Echinococcus multilocularis	carbonyl reductase 1	0.011	0.0152	0.6724
Onchocerca volvulus		0.011	0.0152	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0157	0.0226	1
Entamoeba histolytica	short chain dehydrogenase family protein	0.011	0.0152	1
Echinococcus multilocularis	steroid dehydrogenase	0.011	0.0152	0.6724
Leishmania major	pteridine reductase 1	0.011	0.0152	0.1215
Trypanosoma brucei	short-chain dehydrogenase, putative	0.011	0.0152	0.1215
Onchocerca volvulus		0.011	0.0152	1
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.011	0.0152	0.1215
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.011	0.0152	0.1215
Schistosoma mansoni	carbonyl reductase	0.011	0.0152	0.6884
Entamoeba histolytica	hypothetical protein, conserved	0.011	0.0152	1
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	1
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0816	0.1248	1
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.011	0.0152	1
Onchocerca volvulus		0.011	0.0152	1
Onchocerca volvulus		0.011	0.0152	1
Leishmania major	dehydrogenase-like protein	0.011	0.0152	0.1215
Leishmania major	quinonoid dihydropteridine reductase	0.011	0.0152	0.1215
Schistosoma mansoni	steroid dehydrogenase	0.011	0.0152	0.6884
Brugia malayi	putative malonyl-CoA decarboxylase	0.2077	0.3206	1
Echinococcus granulosus	histone deacetylase 6	0.0047	0.0054	0.2376
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Toxoplasma gondii	histone deacetylase HDAC1	0.004	0.0044	0.2894
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.011	0.0152	0.1215
Echinococcus granulosus	carbonyl reductase 1	0.011	0.0152	0.6735
Loa Loa (eye worm)	oxidoreductase	0.011	0.0152	0.0473
Loa Loa (eye worm)	hypothetical protein	0.011	0.0152	0.0473
Echinococcus multilocularis	retinol dehydrogenase 11	0.011	0.0152	0.6724
Entamoeba histolytica	short chain dehydrogenase family protein	0.011	0.0152	1
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.0152	0.1215
Onchocerca volvulus		0.011	0.0152	1
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Echinococcus multilocularis	histone deacetylase 6	0.0047	0.0054	0.2372
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.011	0.0152	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0152	0.0473
Echinococcus granulosus	retinol dehydrogenase 11	0.011	0.0152	0.6735
Loa Loa (eye worm)	histone deacetylase	0.004	0.0044	0.0137
Leishmania major	hypothetical protein, conserved	0.011	0.0152	0.1215
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Leishmania major	histone deacetylase, putative	0.004	0.0044	0.0352
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.011	0.0152	1
Toxoplasma gondii	oxidoreductase, putative	0.011	0.0152	1
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	0.2077	0.3206	1
Trypanosoma cruzi	histone deacetylase, putative	0.004	0.0044	0.0352
Brugia malayi	Histone deacetylase family protein	0.004	0.0044	0.0137
Echinococcus granulosus	carbonyl reductase 1	0.011	0.0152	0.6735
Echinococcus granulosus	histone deacetylase	0.004	0.0044	0.1949
Schistosoma mansoni	steroid dehydrogenase	0.011	0.0152	0.6884
Echinococcus multilocularis	histone deacetylase	0.004	0.0044	0.1946
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.011	0.0152	1
Plasmodium vivax	hypothetical protein, conserved	0.011	0.0152	1
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Toxoplasma gondii	carbonyl reductase 1, putative	0.011	0.0152	1
Schistosoma mansoni	steroid dehydrogenase	0.011	0.0152	0.6884
Toxoplasma gondii	histone deacetylase HDAC5	0.0012	0	0.0024
Onchocerca volvulus		0.011	0.0152	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.011	0.0152	1
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.011	0.0152	0.6735
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.011	0.0152	1
Onchocerca volvulus		0.011	0.0152	1
Leishmania major	hypothetical protein, conserved	0.011	0.0152	0.1215
Echinococcus granulosus	WW domain containing oxidoreductase	0.011	0.0152	0.6735
Giardia lamblia	Hypothetical protein	0.011	0.0152	1
Echinococcus granulosus	ankyrin repeat protein	0.0154	0.022	0.9784
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.011	0.0152	0.6884
Leishmania major	quinonoid dihydropteridine reductase	0.011	0.0152	0.1215
Onchocerca volvulus		0.011	0.0152	1
Loa Loa (eye worm)	dehydrogenase	0.011	0.0152	0.0473
Onchocerca volvulus		0.011	0.0152	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0152	0.0473
Echinococcus granulosus	histone deacetylase 6	0.004	0.0044	0.1949
Trypanosoma cruzi	short chain dehydrogenase, putative	0.011	0.0152	0.1215
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.011	0.0152	0.6735
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.011	0.0152	1
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.011	0.0152	1
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Loa Loa (eye worm)	hypothetical protein	0.2077	0.3206	1
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0816	0.1248	1
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Loa Loa (eye worm)	oxidoreductase	0.011	0.0152	0.0473
Echinococcus granulosus	transient receptor potential cation channel	0.0157	0.0225	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0152	0.0473
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.011	0.0152	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.011	0.0152	0.1215
Plasmodium vivax	histone deacetylase 2, putative	0.004	0.0044	0.2894
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	1
Trypanosoma cruzi	short chain dehydrogenase, putative	0.011	0.0152	0.1215
Trypanosoma brucei	oxidoreductase-like protein	0.011	0.0152	0.1215
Entamoeba histolytica	hypothetical protein, conserved	0.011	0.0152	1
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Trypanosoma brucei	histone deacetylase, putative	0.004	0.0044	0.0352
Loa Loa (eye worm)	oxidoreductase	0.011	0.0152	0.0473
Trichomonas vaginalis	steroid dehydrogenase, putative	0.011	0.0152	1
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.011	0.0152	0.0473
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	1
Echinococcus granulosus	hypothetical protein	0.011	0.0152	0.6735
Onchocerca volvulus		0.011	0.0152	1
Brugia malayi	dehydrogenases, short chain protein 9	0.011	0.0152	0.0473
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.011	0.0152	0.6735
Leishmania major	oxidoreductase-like protein	0.011	0.0152	0.1215
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.0152	0.1215
Schistosoma mansoni	steroid dehydrogenase	0.011	0.0152	0.6884
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0025	0.0078
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.011	0.0152	1
Plasmodium falciparum	histone deacetylase, putative	0.004	0.0044	0.2894
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Brugia malayi	oxidoreductase	0.011	0.0152	0.0473
Leishmania major	histone deacetylase, putative	0.004	0.0044	0.0352
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.011	0.0152	1
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.011	0.0152	0.0473
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.011	0.0152	0.5
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.011	0.0152	0.6724
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.011	0.0152	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.011	0.0152	0.1215
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.011	0.0152	0.1215
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.011	0.0152	1
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Brugia malayi	Histone deacetylase family protein	0.004	0.0044	0.0137
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.011	0.0152	0.1215
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Leishmania major	short chain dehydrogenase, putative	0.011	0.0152	0.1215
Schistosoma mansoni	steroid dehydrogenase	0.011	0.0152	0.6884
Schistosoma mansoni	histone deacetylase 4 5	0.004	0.0044	0.1992
Leishmania major	short chain dehydrogenase/reductase, putative	0.011	0.0152	0.1215
Schistosoma mansoni	histone deacetylase 4 5	0.004	0.0044	0.1992
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.011	0.0152	0.6884
Schistosoma mansoni	steroid dehydrogenase	0.011	0.0152	0.6884
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.011	0.0152	0.6884
Plasmodium vivax	histone deacetylase, putative	0.004	0.0044	0.2894
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.011	0.0152	0.1215
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.011	0.0152	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0152	0.0473
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Schistosoma mansoni	steroid dehydrogenase	0.011	0.0152	0.6884
Brugia malayi	Retinol dehydrogenase 12	0.011	0.0152	0.0473
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.011	0.0152	0.1215
Echinococcus multilocularis	conserved hypothetical protein	0.011	0.0152	0.6724
Trypanosoma brucei	short-chain dehydrogenase, putative	0.011	0.0152	0.1215
Echinococcus multilocularis	carbonyl reductase 1	0.011	0.0152	0.6724
Echinococcus multilocularis	oxidoreductase	0.011	0.0152	0.6724
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Loa Loa (eye worm)	oxidoreductase	0.011	0.0152	0.0473
Leishmania major	short chain dehydrogenase-like protein	0.011	0.0152	0.1215
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.011	0.0152	1
Echinococcus multilocularis	carbonyl reductase 1	0.011	0.0152	0.6724
Onchocerca volvulus		0.011	0.0152	1
Plasmodium vivax	steroid dehydrogenase, putative	0.011	0.0152	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.011	0.0152	1
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.011	0.0152	0.6724
Loa Loa (eye worm)	hypothetical protein	0.011	0.0152	0.0473
Echinococcus granulosus	oxidoreductase	0.011	0.0152	0.6735
Echinococcus multilocularis	histone deacetylase 7	0.004	0.0044	0.1946
Entamoeba histolytica	hypothetical protein	0.011	0.0152	1
Schistosoma mansoni	steroid dehydrogenase	0.011	0.0152	0.6884
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.0154	0.022	1
Loa Loa (eye worm)	dehydrogenase	0.011	0.0152	0.0473
Plasmodium falciparum	histone deacetylase 2	0.004	0.0044	0.2894
Echinococcus multilocularis	carbonyl reductase 1	0.011	0.0152	0.6724
Echinococcus multilocularis	transient receptor potential cation channel	0.011	0.0152	0.6724
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Trypanosoma brucei	short-chain dehydrogenase, putative	0.011	0.0152	0.1215
Echinococcus multilocularis	retinol dehydrogenase 11	0.011	0.0152	0.6724
Echinococcus multilocularis	retinol dehydrogenase 13	0.011	0.0152	0.6724
Leishmania major	3-keto-dihydrosphingosine reductase	0.011	0.0152	0.1215
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.011	0.0152	0.1215
Trypanosoma brucei	histone deacetylase 4	0.004	0.0044	0.0352
Leishmania major	quinonoid dihydropteridine reductase	0.011	0.0152	0.1215
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.011	0.0152	1
Trypanosoma brucei	histone deacetylase 3	0.004	0.0044	0.0352
Loa Loa (eye worm)	oxidoreductase	0.011	0.0152	0.0473
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Brugia malayi	Dehydrogenases, short chain protein 2	0.011	0.0152	0.0473
Leishmania major	quinonoid dihydropteridine reductase	0.011	0.0152	0.1215
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.011	0.0152	0.1215
Plasmodium falciparum	steroid dehydrogenase, putative	0.011	0.0152	1
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.0152	0.1215
Echinococcus multilocularis	ankyrin repeat protein	0.0154	0.022	0.9768
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.011	0.0152	0.5
Echinococcus multilocularis	steroid dehydrogenase	0.011	0.0152	0.6724
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0816	0.1248	1
Loa Loa (eye worm)	histone deacetylase 7A	0.004	0.0044	0.0137
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.011	0.0152	1
Trypanosoma cruzi	histone deacetylase, putative	0.004	0.0044	0.0352
Trypanosoma brucei	short-chain dehydrogenase, putative	0.011	0.0152	0.1215
Leishmania major	quinonoid dihydropteridine reductase	0.011	0.0152	0.1215
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.011	0.0152	0.1215
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.011	0.0152	0.1215
Giardia lamblia	Reductase, putative	0.011	0.0152	1
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Leishmania major	hypothetical protein, conserved	0.011	0.0152	0.1215
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.011	0.0152	0.1215
Loa Loa (eye worm)	oxidoreductase	0.011	0.0152	0.0473
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.011	0.0152	0.0473
Leishmania major	quinonoid dihydropteridine reductase	0.011	0.0152	0.1215
Onchocerca volvulus		0.011	0.0152	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.011	0.0152	1
Echinococcus granulosus	carbonyl reductase 1	0.011	0.0152	0.6735
Schistosoma mansoni	short chain dehydrogenase	0.011	0.0152	0.6884
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.011	0.0152	0.1215
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.0152	0.1215

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 880853