Detailed information for compound 910916

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 385.884 | Formula: C22H24ClNO3
  • H donors: 1 H acceptors: 2 LogP: 4.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOC(=O)C1=C(C)N=C2C(=C(O)CC(C2)(C)C)C1c1cccc(c1)Cl
  • InChi: 1S/C22H24ClNO3/c1-5-9-27-21(26)18-13(2)24-16-11-22(3,4)12-17(25)20(16)19(18)14-7-6-8-15(23)10-14/h5-8,10,19,25H,1,9,11-12H2,2-4H3
  • InChiKey: OBBMGFZHNSAMHB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0018 0.0043 0.0172
Onchocerca volvulus Alhambra homolog 0.0028 0.0108 0.0853
Schistosoma mansoni hypothetical protein 0.0065 0.0329 0.1011
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0259 0.4099
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0367 0.1279
Trichomonas vaginalis chromobox protein, putative 0.007 0.0361 0.6036
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0025 0.0087 0.0348
Onchocerca volvulus 0.0049 0.0235 0.1893
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0018 0.0043 0.0043
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0018 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.0662
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0034 0.0204
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0224 0.0566
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0172
Plasmodium falciparum flap endonuclease 1 0.0025 0.0089 0.2294
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0015 0.0025 0.0612
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0113 0.184
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0034 0.0169
Schistosoma mansoni survival motor neuron protein 0.0049 0.0235 0.0718
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0025 0.0353
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0034 0.0864
Brugia malayi Bromodomain containing protein 0.0028 0.0108 0.0433
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0669 1
Onchocerca volvulus 0.0018 0.0043 0.0322
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.0043 0.0172
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0113 0.184
Schistosoma mansoni smad1 5 8 and 0.0016 0.0032 0.0089
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0595 0.2134
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0259 0.6732
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0113 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0113 0.184
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0074 0.0384 0.6225
Loa Loa (eye worm) hypothetical protein 0.0148 0.0837 0.3379
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.0025 0.055
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0498 0.1535
Brugia malayi DnaJ domain containing protein 0.0062 0.0315 0.1268
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0387 0.119
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0595 0.2134
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0173 0.2864
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0032 0.0089
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0669 0.241
Echinococcus granulosus muscleblind protein 0.0148 0.0837 0.2118
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0074 0.0384 0.6289
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0018 0.0043 0.0109
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0004 0.0065
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0367 0.1279
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0018 0.0043 0.0664
Schistosoma mansoni cpg binding protein 0.003 0.0117 0.0351
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.0025 0.0612
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0367 0.5987
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0025 0.0097
Loa Loa (eye worm) HMP-2 protein 0.0212 0.1232 0.4973
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0498 0.8343
Trichomonas vaginalis chromobox protein, putative 0.007 0.0361 0.6036
Treponema pallidum exodeoxyribonuclease (exoA) 0.0074 0.0384 0.6289
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0018 0.0043 0.0172
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0089 0.0089
Schistosoma mansoni GTP-binding protein alpha subunit 0.0018 0.0043 0.0122
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0018 0.0043 0.0109
Brugia malayi Protein cec-1. 0.0011 0.0004 0.0013
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0498 0.0498
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0044 0.0174
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0004 0.0065
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0108 0.0273
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0018 0.0043 0.0172
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0018 0.0043 0.0172
Echinococcus granulosus flap endonuclease 1 0.0025 0.0089 0.0225
Echinococcus multilocularis Chromo domain 0.0011 0.0004 0.0004
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0113 0.2865
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0015 0.0025 0.0097
Loa Loa (eye worm) hypothetical protein 0.0028 0.0108 0.0433
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0329 0.1326
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0018 0.0043 0.0109
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0259 0.4099
Schistosoma mansoni chromobox protein 0.007 0.0361 0.1111
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0089 0.2243
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0025 0.0097
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0025 0.0097
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0074 0.0384 0.1548
Schistosoma mansoni kinase 0.0047 0.022 0.0673
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0018 0.0043 0.0172
Loa Loa (eye worm) hypothetical protein 0.0071 0.0367 0.1478
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0089 0.144
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0015 0.0025 0.0353
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.1182 0.4773
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018 0.0043 0.0122
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0034 0.0169
Loa Loa (eye worm) hypothetical protein 0.0071 0.0367 0.1478
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0367 0.1279
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0089 0.144
Echinococcus multilocularis muscleblind protein 0.0148 0.0837 0.0837
Onchocerca volvulus 0.0012 0.0008 0.0031
Echinococcus granulosus neutral sphingomyelinase 0.0015 0.0025 0.0063
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0113 0.1541
Brugia malayi beta-lactamase 0.0071 0.0367 0.1478
Onchocerca volvulus 0.0071 0.0367 0.2975
Leishmania major trypanothione reductase 0.0047 0.0224 0.3487
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0087 0.1085
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0108 0.0433
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0018 0.0043 0.0109
Echinococcus multilocularis deoxyribonuclease 1 2 0.0015 0.0025 0.0025
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0025 0.0097
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0416 0.1052
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0329 0.0832
Echinococcus granulosus Chromo domain 0.0011 0.0004 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0169
Loa Loa (eye worm) hypothetical protein 0.0065 0.0329 0.1326
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0367 0.1128
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0014 0.0053
Toxoplasma gondii thioredoxin reductase 0.0047 0.0224 0.5789
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.1408 0.3562
Schistosoma mansoni carbon catabolite repressor protein 0.0015 0.0025 0.0065
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0043 0.0664
Leishmania major hypothetical protein, conserved 0.0071 0.0367 0.5987
Brugia malayi jmjC domain containing protein 0.0036 0.0154 0.0621
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0004 0.0013
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0025 0.0353
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0025 0.0097
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0113 0.184
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0087 0.0933
Loa Loa (eye worm) DnaJ domain-containing protein 0.0062 0.0315 0.1268
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0048 0.1751
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0034 0.0034
Brugia malayi G-protein alpha subunit 0.0018 0.0043 0.0172
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0025 0.0353
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0172
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0018 0.0043 0.0664
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0416 0.2476 0.7688
Echinococcus granulosus synaptojanin 1 0.0015 0.0025 0.0063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0087 0.0232
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0087 0.1085
Trichomonas vaginalis ap endonuclease, putative 0.0074 0.0384 0.642
Schistosoma mansoni nocturnin 0.0015 0.0025 0.0065
Mycobacterium leprae Probable lipase LipE 0.0071 0.0367 0.4806
Echinococcus multilocularis expressed protein 0.0018 0.0043 0.0043
Loa Loa (eye worm) RNA binding protein 0.0062 0.0311 0.1255
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0596 0.2403
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0087 0.0348
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0004 0.0065
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0192 0.1539
Trypanosoma brucei trypanothione reductase 0.0047 0.0224 0.3487
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0034 0.0095
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.0662
Schistosoma mansoni cpg binding protein 0.0028 0.0107 0.032
Schistosoma mansoni pangolin 0.0142 0.0801 0.248
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0043 0.0664
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0015 0.0025 0.0353
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0367 0.6129
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0367 0.6129
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0213 0.3533
Brugia malayi 6-phosphofructokinase 0.0108 0.0596 0.2403
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0043 0.0662
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0596 0.8741
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0367 0.9549
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.0662
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0015 0.0025 0.0063
Echinococcus granulosus jumonji domain containing protein 0.004 0.0176 0.0445
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0235 0.0945
Echinococcus granulosus beta catenin 0.0212 0.1232 0.3116
Brugia malayi glutathione reductase 0.0047 0.0224 0.0901
Brugia malayi beta-lactamase family protein 0.0071 0.0367 0.1478
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0169
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0595 0.8733
Schistosoma mansoni synaptojanin 0.0015 0.0025 0.0065
Treponema pallidum NADH oxidase 0.0016 0.0034 0.0169
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0367 0.1478
Brugia malayi phosphofructokinase 0.0108 0.0596 0.2403
Loa Loa (eye worm) G protein alpha subunit 3 0.0018 0.0043 0.0172
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0025 0.0025
Toxoplasma gondii exonuclease III APE 0.0074 0.0384 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0498 0.8282
Brugia malayi MH1 domain containing protein 0.0016 0.0032 0.0128
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0113 0.2912
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0013
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0074 0.0384 0.7594
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0087 0.0933
Brugia malayi Heterochromatin protein 1 0.007 0.0361 0.1456
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0596 0.184
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0669 0.241
Schistosoma mansoni hypothetical protein 0.0079 0.0416 0.1281
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0004 0.0065
Echinococcus multilocularis cpg binding protein 0.003 0.0117 0.0117
Mycobacterium ulcerans lipase LipD 0.0071 0.0367 0.5918
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0004 0.0004
Echinococcus granulosus chromobox protein 2 0.0011 0.0004 0.001
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0015 0.0025 0.0353
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0015 0.0025 0.0353
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0025 0.0612
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0498 0.8343
Echinococcus granulosus dnaJ subfamily C 6 0.0062 0.0315 0.0796
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0018 0.0043 0.0172
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.2698 1
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0089 0.2294
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0103 0.1683
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0025 0.0355
Echinococcus granulosus Chromobox protein 3 0.0011 0.0004 0.001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0329 0.0329
Echinococcus multilocularis chromobox protein 1 0.007 0.0361 0.0361
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0596 0.2403
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0034 0.0804
Schistosoma mansoni cpg binding protein 0.003 0.0117 0.0351
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0034 0.0169
Giardia lamblia PHD finger protein 15 0.0028 0.0108 0.1758
Loa Loa (eye worm) Smad1 0.0016 0.0032 0.0128
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0018 0.0043 0.0122
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0031 0.0109
Schistosoma mansoni hypothetical protein 0.0065 0.0329 0.1011
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0498 0.8343
Schistosoma mansoni smad 0.0016 0.0032 0.0089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0416 0.2476 0.2476
Onchocerca volvulus 0.0018 0.0043 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0103 0.1683
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0596 0.2403
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0032 0.0032
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0014 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0034 0.0093
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0367 0.1128
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0596 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0173 0.0698
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0004 0.0013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.1182 0.4773
Echinococcus multilocularis GPCR, family 2 0.0065 0.0329 0.0329
Echinococcus multilocularis geminin 0.0537 0.322 0.322
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0311 0.1255
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0113 0.184
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0192 0.3171
Loa Loa (eye worm) hypothetical protein 0.014 0.0787 0.3178
Loa Loa (eye worm) hypothetical protein 0.0148 0.0837 0.3379
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0154 0.0621
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0018 0.0043 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0008 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0498 0.8343
Brugia malayi Flap endonuclease-1 0.0025 0.0089 0.0357
Brugia malayi RNA binding protein 0.0062 0.0311 0.1255
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0108 0.2739
Echinococcus granulosus traf and tnf receptor associated protein 0.0015 0.0025 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0169
Schistosoma mansoni smad1 5 8 and 0.0016 0.0032 0.0089
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0034 0.0169
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.0025 0.0353
Giardia lamblia Kinase, PLK 0.0092 0.0498 1
Schistosoma mansoni GTP-binding protein alpha subunit 0.0018 0.0043 0.0122
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.0025 0.055
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0113 0.2912
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0074 0.0384 0.6289
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0169
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0142 0.0801 0.0801
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0087 0.0232
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0504 0.1274
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0025 0.0353
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0018 0.0043 0.0043
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0192 0.3171
Echinococcus multilocularis chromobox protein 2 0.0011 0.0004 0.0004
Echinococcus granulosus chromobox protein 1 0.007 0.0361 0.0913
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0004 0.0013
Schistosoma mansoni hypothetical protein 0.0028 0.0108 0.0324
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0145 0.0145
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0498 0.2007
Brugia malayi CHD4 protein 0.0013 0.0014 0.0053
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0034 0.0136
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0087 0.14
Plasmodium falciparum thioredoxin reductase 0.0016 0.0034 0.0864
Loa Loa (eye worm) hypothetical protein 0.0053 0.0259 0.1043
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0074 0.0384 0.6289
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0034 0.0864
Brugia malayi Thioredoxin reductase 0.0047 0.0224 0.0901
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0307
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0329 0.0329
Trypanosoma brucei polo-like protein kinase 0.0092 0.0498 0.8282
Echinococcus granulosus Smad4 0.0016 0.0032 0.0082
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0074 0.0384 1
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0224 0.3487
Brugia malayi hypothetical protein 0.0011 0.0004 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0042 0.0064
Echinococcus multilocularis dnaJ subfamily C 6 0.0062 0.0315 0.0315
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0025 0.0353
Schistosoma mansoni hypothetical protein 0.0015 0.0025 0.0065
Schistosoma mansoni hypothetical protein 0.014 0.0787 0.2436
Loa Loa (eye worm) hypothetical protein 0.0071 0.0367 0.1478
Schistosoma mansoni hypothetical protein 0.0062 0.0315 0.0966
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0025 0.0097
Echinococcus granulosus expressed protein 0.0018 0.0043 0.0109
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0074 0.0384 0.0971
Echinococcus multilocularis chromobox protein 1 0.007 0.0361 0.0361
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0074 0.0384 0.642
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0015 0.0025 0.0353
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0034 0.0169
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.1408 0.1408
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0034 0.0169
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0192
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0172
Loa Loa (eye worm) hypothetical protein 0.0071 0.0367 0.1478
Trichomonas vaginalis esterase, putative 0.0071 0.0367 0.6129
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0025 0.0097
Echinococcus multilocularis peregrin 0.0028 0.0108 0.0108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.0662
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0018 0.0043 0.0172
Entamoeba histolytica G protein alpha subunit, putative 0.0018 0.0043 0.0664
Echinococcus granulosus GPCR family 2 0.0065 0.0329 0.0832
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0034 0.0087
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0498 0.4049
Mycobacterium tuberculosis Conserved protein 0.0071 0.0367 0.1279
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0015 0.0025 0.0353
Schistosoma mansoni hypothetical protein 0.0049 0.0235 0.0718
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0087 0.0933
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0259 0.6732
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0311 0.1255
Brugia malayi SET domain containing protein 0.0012 0.0008 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0498 0.8343
Brugia malayi hypothetical protein 0.0241 0.1408 0.5685
Brugia malayi Smad1 0.0016 0.0032 0.0128
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0367 0.5918
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0087 0.1085
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0361 0.1456
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.0662
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0034 0.0864
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0596 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0367 0.1478
Leishmania major hypothetical protein, conserved 0.0053 0.0259 0.4099
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0025 0.0097
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0018 0.0043 0.0122
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0259 0.4099
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0034 0.0169
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0034 0.0036
Echinococcus granulosus smad 0.0016 0.0032 0.0082
Echinococcus multilocularis synaptojanin 1 0.0015 0.0025 0.0025
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.0025 0.055
Mycobacterium tuberculosis Conserved protein 0.0071 0.0367 0.1279
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0025 0.0097
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0498 0.1259
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0224 0.0745
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0013
Mycobacterium ulcerans beta-lactamase 0.0071 0.0367 0.5918
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0595 0.2134
Entamoeba histolytica hypothetical protein 0.0079 0.0416 0.696
Brugia malayi PHD-finger family protein 0.0028 0.0108 0.0433
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0074 0.0384 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0107 0.0429
Loa Loa (eye worm) helicase 0.0011 0.0004 0.0013
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.0025 0.055
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0262 0.6785
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0293 0.1181
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0015 0.0025 0.0065
Onchocerca volvulus 0.0071 0.0367 0.2975
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0367 0.1279
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0113 0.2865
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0367 0.1279
Brugia malayi beta-lactamase family protein 0.0071 0.0367 0.1478
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0595 0.2134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0042 0.0064
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0367 0.5918
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0074 0.0384 1
Plasmodium falciparum glutathione reductase 0.0047 0.0224 0.5817
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0113 0.2912
Brugia malayi exodeoxyribonuclease III family protein 0.0074 0.0384 0.1548
Echinococcus granulosus chromobox protein 1 0.007 0.0361 0.0913
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0087 0.14
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0108 0.2786
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0595 0.2134
Loa Loa (eye worm) HMG box family protein 0.0142 0.0801 0.3235
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0596 0.2136
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.1379 0.5568
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0596 0.0596
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0113 0.2912
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0087 0.0933
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0596 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0416 0.2476 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0087 0.0933
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0176 0.0176
Echinococcus multilocularis neutral sphingomyelinase 0.0015 0.0025 0.0025
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0048 0.1223
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0034 0.0516
Mycobacterium ulcerans hypothetical protein 0.0071 0.0367 0.5918
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0087 0.0933
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018 0.0043 0.0122
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0108 0.0324
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0032 0.0082
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0367 0.1279
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0596 1
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0367 0.6129
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0596 1
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.0043 0.0172
Schistosoma mansoni synaptojanin 0.0015 0.0025 0.0065
Onchocerca volvulus 0.0071 0.0367 0.2975
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0025 0.0355
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0367 0.6129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0416 0.2476 0.2476
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0034 0.0169
Trichomonas vaginalis Phospholipase C precursor, putative 0.0015 0.0025 0.0353
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0025 0.0097
Plasmodium falciparum glutathione reductase 0.0016 0.0034 0.0864
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0015 0.0025 0.0612
Mycobacterium tuberculosis Probable reductase 0.0108 0.0595 0.2134
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0018 0.0043 0.0664
Schistosoma mansoni hypothetical protein 0.0537 0.322 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0224 0.0224
Schistosoma mansoni flap endonuclease-1 0.0023 0.0074 0.0219
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0025 0.0097
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0043 0.0664
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.0662
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0301 0.0923
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0015 0.0025 0.0025
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0018 0.0043 0.0043
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0113 0.184
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0097
Loa Loa (eye worm) hypothetical protein 0.0025 0.0087 0.0348
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0008 0.0029
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0089 0.136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0042 0.0064
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0596 1
Entamoeba histolytica hypothetical protein 0.0079 0.0416 0.696
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.1379 0.5568
Brugia malayi hypothetical protein 0.0034 0.0144 0.0578
Schistosoma mansoni neutral sphingomyelinase 0.0015 0.0025 0.0065
Mycobacterium tuberculosis Conserved protein 0.0071 0.0367 0.1279
Echinococcus multilocularis beta catenin 0.0212 0.1232 0.1232
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0192
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0089 0.1127
Echinococcus multilocularis Smad4 0.0016 0.0032 0.0032
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0596 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0498 0.8282
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0113 0.186
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0596 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0108 0.0108
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0416 0.1281
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0089 0.0357
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.0043 0.0172
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0204 0.1182 0.4773
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0018 0.0043 0.0122
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0169
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0018 0.0043 0.0172
Schistosoma mansoni hypothetical protein 0.0517 0.3093 0.9606
Brugia malayi CCR4 0.0015 0.0025 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0311 0.0956
Schistosoma mansoni hypothetical protein 0.0537 0.322 1
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0018 0.0043 0.0664
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0169
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0074 0.0384 0.1343
Brugia malayi MH2 domain containing protein 0.0016 0.0032 0.0128
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0018 0.0043 0.0172
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0504 0.0504
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0329 0.1326
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0367 0.0367
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0048 0.0244
Echinococcus multilocularis smad 0.0016 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0065 0.0329 0.1011
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0107 0.0429
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0311 0.0956
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0014 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0367 0.6129
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0004 0.0004
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0034 0.0516
Plasmodium vivax exodeoxyribonuclease III, putative 0.0015 0.0025 0.0612
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0018 0.0043 0.0043
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0224 0.5817
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0025 0.0097
Onchocerca volvulus Cirhin homolog 0.0211 0.1223 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0669 0.241
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.008 0.0202
Toxoplasma gondii ABC1 family protein 0.0071 0.0367 0.9546
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0004 0.001
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0004 0.0065
Plasmodium falciparum DNase I-like protein, putative 0.0015 0.0025 0.0612
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0042 0.0064
Schistosoma mansoni smad1 5 8 and 0.0016 0.0032 0.0089
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0596 1
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0212 0.1232 0.4973
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0004 0.0013
Onchocerca volvulus 0.0031 0.0122 0.0966
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0154 0.0391
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0034 0.0864
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0329 0.1326
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0169
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.0025 0.055
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0416 0.2476 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0087 0.0933
Mycobacterium ulcerans hypothetical protein 0.0025 0.0087 0.0933
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0108 0.2739
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0008 0.0029
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0113 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0025 0.0353
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0498 0.8343
Schistosoma mansoni ap endonuclease 0.0074 0.0384 0.1181
Plasmodium falciparum thioredoxin reductase 0.0047 0.0224 0.5817
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0142 0.0801 0.2028
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0018 0.0043 0.0043
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0015 0.0025 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0416 0.2476 0.7688
Plasmodium vivax glutathione reductase, putative 0.0047 0.0224 0.5817
Brugia malayi MH1 domain containing protein 0.0016 0.0032 0.0128
Entamoeba histolytica hypothetical protein 0.0079 0.0416 0.696
Loa Loa (eye worm) hypothetical protein 0.0241 0.1408 0.5685
Loa Loa (eye worm) hypothetical protein 0.0071 0.0367 0.1478
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0087 0.0348
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0311 0.0956
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0416 0.2476 0.6265
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0311 0.0311
Onchocerca volvulus 0.0018 0.0043 0.0322
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0113 0.2865
Onchocerca volvulus 0.0015 0.0025 0.0172
Brugia malayi hypothetical protein 0.0018 0.0043 0.0172
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.0787 0.3178
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0087 0.0348
Echinococcus granulosus geminin 0.0537 0.322 0.8146
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0013
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0596 0.1507
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0034 0.0169
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0018 0.0043 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0173 0.2864
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0224 0.0901
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0596 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0018 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0097
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0025 0.0063
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0015 0.0025 0.0612
Schistosoma mansoni hypothetical protein 0.0024 0.008 0.0236
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0018 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.1182 0.4773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0172
Echinococcus granulosus peregrin 0.0028 0.0108 0.0273
Echinococcus granulosus pangolin 0.0142 0.0801 0.2028
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.0025 0.0612
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0311 0.0956
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0013
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0032 0.0128
Schistosoma mansoni Smad4 0.0016 0.0032 0.0089
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0074 0.0384 0.6289
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0498 0.2007
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0498 0.8343
Brugia malayi hypothetical protein 0.0079 0.0416 0.1677
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0154 0.0468
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0173 0.139
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0048 0.0087
Loa Loa (eye worm) hypothetical protein 0.0025 0.0087 0.0348
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0089 0.1127
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.0025 0.055
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0192
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0015 0.0025 0.0063
Onchocerca volvulus 0.0015 0.0025 0.0172
Trichomonas vaginalis protein kinase inhibitor, putative 0.0062 0.0315 0.525
Loa Loa (eye worm) hypothetical protein 0.0031 0.0122 0.0489
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0329 0.0832
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0025 0.0097
Echinococcus multilocularis traf and tnf receptor associated protein 0.0015 0.0025 0.0025
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0025 0.0353
Schistosoma mansoni cript-related 0.0015 0.0025 0.0065
Onchocerca volvulus Putative neutral sphingomyelinase 0.0015 0.0025 0.0172
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0015 0.0025 0.0353
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0013
Schistosoma mansoni beta-catenin 0.0212 0.1232 0.3818
Plasmodium falciparum phd finger protein, putative 0.0028 0.0108 0.2786
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0032 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0416 0.2476 0.7688
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0311 0.0956
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0213 0.3533
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.0025 0.055
Brugia malayi chromobox protein homolog 3 0.0039 0.0173 0.0698
Brugia malayi hypothetical protein 0.0053 0.0259 0.1043
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0031 0.0109
Schistosoma mansoni chromobox protein 0.007 0.0361 0.1111
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0043 0.0662
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0074 0.0384 0.0384
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.0025 0.0353
Echinococcus granulosus tar DNA binding protein 0.0062 0.0311 0.0788
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0192
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0367 0.0927
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0192
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0311 0.1255
Onchocerca volvulus 0.0028 0.0107 0.0845
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0154 0.0468
Entamoeba histolytica hypothetical protein 0.0079 0.0416 0.696
Loa Loa (eye worm) glutathione reductase 0.0047 0.0224 0.0901
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0025 0.0097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0169
Brugia malayi MH2 domain containing protein 0.0236 0.1379 0.5568
Brugia malayi HMG box family protein 0.0142 0.0801 0.3235
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0089 0.1127
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0015 0.0025 0.0353
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0004 0.0065
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0018 0.0043 0.0172
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0025 0.0353
Echinococcus granulosus hypothetical protein 0.0657 0.3953 1
Brugia malayi 6-phosphofructokinase 0.0108 0.0596 0.2403
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0034 0.0804
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0367 0.1279
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0018 0.0043 0.0122
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0498 0.8282
Brugia malayi Muscleblind-like protein 0.0148 0.0837 0.3379
Schistosoma mansoni ap endonuclease 0.0074 0.0384 0.1181
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0048 0.1223
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0087 0.14
Trichomonas vaginalis ap endonuclease, putative 0.0074 0.0384 0.642
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0025 0.0353
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0837 0.0837
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0259 0.671
Brugia malayi TAR-binding protein 0.0062 0.0311 0.1255
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0113 0.184
Brugia malayi MH2 domain containing protein 0.0016 0.0032 0.0128
Echinococcus granulosus cpg binding protein 0.003 0.0117 0.0296
Loa Loa (eye worm) beta-lactamase 0.0071 0.0367 0.1478
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0596 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0097
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0367 0.5987
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0043 0.0664
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0498 0.8343
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0416 0.2476 0.6265
Echinococcus granulosus FTZ F1 alpha 0.039 0.2321 0.5871
Brugia malayi jmjC domain containing protein 0.0093 0.0504 0.2032
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0113 0.184
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0367 0.4806
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0596 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0232 0.0935
Schistosoma mansoni hypothetical protein 0.0065 0.0329 0.1011
Echinococcus multilocularis protein pangolin J 0.0142 0.0801 0.0801
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0596 0.184
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0416 0.0416
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0015 0.0025 0.0612
Loa Loa (eye worm) hypothetical protein 0.0071 0.0367 0.1478
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0367 0.5987
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0259 0.6732
Onchocerca volvulus 0.0025 0.0087 0.068
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0032 0.0128

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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