Detailed information for compound 940581

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 377.951 | Formula: C21H32ClN3O
  • H donors: 2 H acceptors: 1 LogP: 5.22 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(NCCCCCCNC2CCC2)c2c(c1)c(C)ccn2.Cl
  • InChi: 1S/C21H31N3O.ClH/c1-16-10-13-24-21-19(16)14-18(25-2)15-20(21)23-12-6-4-3-5-11-22-17-8-7-9-17;/h10,13-15,17,22-23H,3-9,11-12H2,1-2H3;1H
  • InChiKey: DGSNGLMYWXOEBA-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.1798 0.2329 0.8996
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0009 0.0004
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0108 0.0374
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0033 0.0332
Trichomonas vaginalis maltase-glucoamylase, putative 0.1995 0.2588 1
Brugia malayi Beta-glucuronidase precursor 0.0327 0.0397 0.0392
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0108 0.8458
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0108 0.0396
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0046 0.0029 0.0088
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0039 0.0038
Schistosoma mansoni ceramide glucosyltransferase 0.1186 0.1526 0.1729
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0108 0.0107
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0364 0.0446 0.0502
Loa Loa (eye worm) hypothetical protein 0.0145 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0051 0.0035 0.0035
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0643 0.0812 0.3123
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0111 0.8666
Echinococcus granulosus mannosyl oligosaccharide 12 alpha mannosidase 0.0046 0.0029 0.0028
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0108 0.0107
Brugia malayi Glycosyl hydrolases family 31 protein 0.0885 0.1131 0.1127
Schistosoma mansoni alpha-amylase 0.0072 0.0063 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.056 0.0703 0.2699
Loa Loa (eye worm) amylo-alpha-1,6-glucosidase 0.0313 0.0379 0.0379
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0072 0.0063 0.0058
Loa Loa (eye worm) trehalase 0.0045 0.0027 0.0027
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0033 0.0104
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0033 0.0081
Loa Loa (eye worm) trehalase 0.0045 0.0027 0.0027
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.1021 0.1309 0.1304
Mycobacterium tuberculosis Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas 0.0072 0.0063 0.4642
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0033 0.0104
Entamoeba histolytica glycogen debranching enzyme, putative 0.0643 0.0812 0.3123
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0108 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0055 0.0169
Schistosoma mansoni lipoxygenase 0.0054 0.0039 0.0039
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0342 0.0417 0.0417
Mycobacterium tuberculosis Probable reductase 0.0109 0.0111 0.8666
Echinococcus multilocularis beta D xylosidase 2 0.0032 0.001 0.0009
Schistosoma mansoni alpha-glucosidase 0.6728 0.8802 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0885 0.1131 0.1658
Leishmania major trypanothione reductase 0.0048 0.0031 0.0073
Loa Loa (eye worm) hypothetical protein 0.0045 0.0027 0.0027
Echinococcus multilocularis lysosomal alpha glucosidase 0.764 1 1
Schistosoma mansoni lamin 0.0052 0.0037 0.0036
Echinococcus multilocularis neutral alpha glucosidase AB 0.1995 0.2588 0.2587
Echinococcus granulosus non lysosomal glucosylceramidase 0.1029 0.1319 0.1318
Loa Loa (eye worm) alpha amylase 0.0072 0.0063 0.0063
Trichomonas vaginalis sucrase-isomaltase, putative 0.1798 0.2329 0.8996
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0049 0.005
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.1995 0.2588 1
Plasmodium falciparum glutathione reductase 0.0048 0.0031 0.2301
Toxoplasma gondii Alpha-galactosidase 0.0029 0.0006 0.0000004957
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0046 0.0029 0.0088
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0033 0.0012 0.0023
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0108 0.0309
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.011 0.0113 1
Brugia malayi Trehalase family protein 0.013 0.0138 0.0134
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0049 0.0049
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0031 0.0029
Echinococcus granulosus expressed protein 0.0376 0.0461 0.046
Echinococcus granulosus ceramide glucosyltransferase 0.1186 0.1526 0.1525
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0033 0.0081
Loa Loa (eye worm) trehalase 0.013 0.0138 0.0138
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0019 0.0017
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0364 0.0446 0.0445
Loa Loa (eye worm) RNA binding protein 0.0061 0.0049 0.0049
Trypanosoma brucei glycosyl hydrolase-like protein 0.0885 0.1131 0.4343
Schistosoma mansoni ceramide glucosyltransferase 0.1186 0.1526 0.1729
Echinococcus multilocularis transfer RNA-Trp 0.0046 0.0029 0.0028
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0012 0.0023
Loa Loa (eye worm) hypothetical protein 0.0885 0.1131 0.1131
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0364 0.0446 0.0445
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0005 0.000004214
Schistosoma mansoni alpha-amylase 0.0072 0.0063 0.0066
Treponema pallidum hypothetical protein 0.0045 0.0027 0.2067
Echinococcus multilocularis lamin 0.0052 0.0037 0.0035
Schistosoma mansoni thyroid hormone receptor 0.0133 0.0143 0.0158
Entamoeba histolytica beta-galactosidase, putative 0.0378 0.0465 0.1776
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0885 0.1131 0.4356
Echinococcus multilocularis mannosyl oligosaccharide 1,2 alpha mannosidase 0.0046 0.0029 0.0028
Loa Loa (eye worm) alpha-L-fucosidase 0.1937 0.2512 0.2512
Mycobacterium ulcerans trehalose synthase TreS 0.0072 0.0063 0.0166
Trypanosoma brucei protein kinase, putative 0.0049 0.0033 0.0081
Echinococcus granulosus lamin 0.0052 0.0037 0.0035
Echinococcus granulosus fucosidase alpha L 1 tissue 0.2444 0.3177 0.3176
Schistosoma mansoni hypothetical protein 0.0032 0.001 0.0006
Schistosoma mansoni hypothetical protein 0.0397 0.049 0.0551
Trichomonas vaginalis inositol monophosphatase, putative 0.0033 0.0012 0.0023
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.049 0.0488
Giardia lamblia Ceramide glucosyltransferase 0.0538 0.0674 0.8288
Loa Loa (eye worm) hypothetical protein 0.013 0.0138 0.0138
Loa Loa (eye worm) trehalase 0.013 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0296 0.0357 0.0357
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0033 0.0012 0.0023
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0108 0.0374
Brugia malayi hypothetical protein 0.013 0.0138 0.0134
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0049 0.0044
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0296 0.0357 0.04
Loa Loa (eye worm) hypothetical protein 0.0045 0.0027 0.0027
Brugia malayi hypothetical protein 0.0144 0.0158 0.0153
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0033 0.0081
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0108 0.0396
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0033 0.0081
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0033 0.0081
Brugia malayi trehalase I 0.0045 0.0027 0.0022
Schistosoma mansoni alpha-l-fucosidase 0.1937 0.2512 0.285
Schistosoma mansoni bile acid beta-glucosidase-related 0.1029 0.1319 0.1494
Schistosoma mansoni cpg binding protein 0.0029 0.0007 0.0002
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0364 0.0446 0.0502
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0127 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0055 0.0169
Echinococcus multilocularis ceramide glucosyltransferase 0.1186 0.1526 0.1525
Loa Loa (eye worm) hypothetical protein 0.013 0.0138 0.0138
Schistosoma mansoni lamin 0.0052 0.0037 0.0036
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0108 0.0396
Schistosoma mansoni hypothetical protein 0.0464 0.0578 0.0652
Brugia malayi Melibiase family protein 0.0296 0.0357 0.0352
Loa Loa (eye worm) hypothetical protein 0.0031 0.0009 0.0009
Trichomonas vaginalis glycoside hydrolase, putative 0.075 0.0953 0.3667
Brugia malayi Thioredoxin reductase 0.0048 0.0031 0.0026
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0111 0.8666
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.1995 0.2588 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0006 0.5
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0108 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0029 0.0088
Echinococcus granulosus neutral alpha glucosidase AB 0.1995 0.2588 0.2587
Leishmania major alpha glucosidase II subunit, putative 0.1995 0.2588 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0037 0.0037
Echinococcus multilocularis thyroid hormone receptor alpha 0.0133 0.0143 0.0142
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0364 0.0446 0.0445
Schistosoma mansoni mannosyl-oligosaccharide alpha-12-mannosidase 0.0046 0.0029 0.0027
Brugia malayi glutathione reductase 0.0048 0.0031 0.0026
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0055 0.0169
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0033 0.0032
Toxoplasma gondii thioredoxin reductase 0.0048 0.0031 0.0095
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0127 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0049 0.005
Brugia malayi Glycosyl hydrolases family 31 protein 0.1995 0.2588 0.2585
Trichomonas vaginalis alpha-glucosidase, putative 0.1995 0.2588 1
Trypanosoma brucei glucosidase, putative 0.1995 0.2588 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0029 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0046 0.0029 0.0029
Brugia malayi Trehalase protein 5 0.0045 0.0027 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0138 0.0513
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0033 0.0032
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0046 0.0029 0.0088
Loa Loa (eye worm) hypothetical protein 0.0085 0.0079 0.0079
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0111 0.8666
Onchocerca volvulus 0.5201 0.6797 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0055 0.0191
Echinococcus granulosus alpha glucosidase 0.0072 0.0063 0.0062
Brugia malayi Inositol-1 0.0033 0.0012 0.0007
Echinococcus granulosus beta D xylosidase 2 0.0032 0.001 0.0009
Brugia malayi TAR-binding protein 0.0061 0.0049 0.0044
Echinococcus multilocularis non lysosomal glucosylceramidase 0.1029 0.1319 0.1318
Trichomonas vaginalis glucosylceramidase, putative 0.1021 0.1309 0.5044
Loa Loa (eye worm) inositol-1 0.0033 0.0012 0.0012
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0108 0.8458
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0019 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0108 0.0396
Loa Loa (eye worm) MH2 domain-containing protein 0.0108 0.011 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.1995 0.2588 1
Brugia malayi RNA binding protein 0.0061 0.0049 0.0044
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0033 0.0104
Echinococcus multilocularis expressed protein 0.0376 0.0461 0.046
Echinococcus multilocularis glycogen debranching enzyme 0.0643 0.0812 0.0811
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.0027 0.0022
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0039 0.0038
Onchocerca volvulus Trehalase homolog 0.013 0.0138 0.0197
Plasmodium vivax hypothetical protein, conserved 0.011 0.0113 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0055 0.0169
Loa Loa (eye worm) TRE-2 protein 0.013 0.0138 0.0138
Onchocerca volvulus 0.013 0.0138 0.0197
Brugia malayi manba-prov protein 0.0181 0.0207 0.0202
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.013 0.0129
Loa Loa (eye worm) hypothetical protein 0.0694 0.088 0.088
Schistosoma mansoni bile acid beta-glucosidase-related 0.1029 0.1319 0.1494
Trichomonas vaginalis beta-glucosidase, putative 0.0394 0.0486 0.1859
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0342 0.0417 0.0412
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0012 0.0023
Onchocerca volvulus Glucosylceramidase homolog 0.067 0.0848 0.1241
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0033 0.0104
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0055 0.0051
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0111 0.8666
Trichomonas vaginalis glucosylceramidase, putative 0.067 0.0848 0.3259
Brugia malayi MH2 domain containing protein 0.0108 0.011 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0049 0.005
Trichomonas vaginalis alpha-glucosidase, putative 0.1995 0.2588 1
Trichomonas vaginalis alpha-glucosidase, putative 0.1995 0.2588 1
Schistosoma mansoni cpg binding protein 0.0029 0.0007 0.0002
Echinococcus multilocularis lysosomal alpha glucosidase 0.764 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.0027 0.0027
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0046 0.0029 0.0088
Echinococcus granulosus tar DNA binding protein 0.0061 0.0049 0.0048
Echinococcus granulosus glycogen debranching enzyme 0.0643 0.0812 0.0811
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0046 0.0029 0.0088
Schistosoma mansoni beta-galactosidase 0.0361 0.0443 0.0498
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0108 0.0108
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.1021 0.1309 0.1309
Echinococcus multilocularis lamin dm0 0.0052 0.0037 0.0035
Brugia malayi trehalase 0.0045 0.0027 0.0022
Schistosoma mansoni hypothetical protein 0.0031 0.0009 0.0004
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.013 0.0129
Trichomonas vaginalis alpha-glucosidase, putative 0.1995 0.2588 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0027 0.0027
Brugia malayi Trehalase family protein 0.013 0.0138 0.0134
Schistosoma mansoni beta-mannosidase 0.0181 0.0207 0.0229
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0031 0.0029
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0072 0.0063 0.0058
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0046 0.0029 0.0088
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0033 0.0104
Echinococcus granulosus cpg binding protein 0.0029 0.0007 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.1021 0.1309 0.5044
Trichomonas vaginalis glucosylceramidase, putative 0.067 0.0848 0.3259
Mycobacterium ulcerans alpha-L-fucosidase 0.2444 0.3177 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0052 0.0037 0.0037
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0046 0.0029 0.0088
Echinococcus multilocularis endoplasmic reticulum mannosyl oligosaccharide 0.0046 0.0029 0.0028
Loa Loa (eye worm) mannosidase 0.0046 0.0029 0.0029
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0046 0.0029 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.1021 0.1309 0.5044
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0127 1
Schistosoma mansoni alpha-amylase 0.0072 0.0063 0.0066
Trichomonas vaginalis alpha-glucosidase, putative 0.0885 0.1131 0.4356
Echinococcus granulosus endoplasmic reticulum mannosyl oligosaccharide 0.0046 0.0029 0.0028
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0387 0.0476 0.0536
Loa Loa (eye worm) hypothetical protein 0.0045 0.0027 0.0027
Brugia malayi phosphofructokinase 0.0107 0.0108 0.0103
Entamoeba histolytica oligo-1,6-glucosidase, putative 0.0072 0.0063 0.022
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0055 0.0055
Echinococcus granulosus dnaJ subfamily B 0.0397 0.049 0.0488
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0885 0.1131 0.4356
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0108 0.0396
Echinococcus multilocularis beta galactosidase 0.0361 0.0443 0.0441
Brugia malayi Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1 0.0046 0.0029 0.0024
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0031 0.0073
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.1186 0.1526 0.224
Trichomonas vaginalis beta-galactosidase, putative 0.056 0.0703 0.2699
Plasmodium vivax glutathione reductase, putative 0.0048 0.0031 0.2301
Brugia malayi Trehalase family protein 0.013 0.0138 0.0134
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0033 0.0012 0.0005
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0046 0.0029 0.0088
Onchocerca volvulus 0.013 0.0138 0.0197
Schistosoma mansoni thyroid hormone receptor 0.0133 0.0143 0.0158
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0296 0.0357 0.1359
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0046 0.0029 0.0088
Loa Loa (eye worm) intermediate filament protein 0.0052 0.0037 0.0037
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0885 0.1131 0.4343
Loa Loa (eye worm) alpha amylase 0.0072 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0827 0.1054 0.1192
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0033 0.0032
Trichomonas vaginalis alpha-L-fucosidase, putative 0.085 0.1084 0.4175
Loa Loa (eye worm) TRE-1 protein 0.013 0.0138 0.0138
Echinococcus granulosus lysosomal alpha glucosidase 0.764 1 1
Loa Loa (eye worm) ceramide glucosyltransferase 0.1186 0.1526 0.1526
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0046 0.0029 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0706 0.0895 0.3443
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0111 0.8666
Trichomonas vaginalis glucosylceramidase, putative 0.1021 0.1309 0.5044
Echinococcus multilocularis inositol monophosphatase 1 0.0033 0.0012 0.0011
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0296 0.0357 0.04
Loa Loa (eye worm) hypothetical protein 0.013 0.0138 0.0138
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0031 0.2301
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.0045 0.0027 0.0027
Loa Loa (eye worm) trehalase 0.013 0.0138 0.0138
Brugia malayi Alpha-L-fucosidase family protein 0.1937 0.2512 0.2508
Mycobacterium tuberculosis Trehalose synthase TreS 0.0072 0.0063 0.4642
Onchocerca volvulus 0.0052 0.0037 0.0047
Echinococcus multilocularis alpha glucosidase 0.0072 0.0063 0.0062
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0108 0.0396
Echinococcus granulosus bile acid beta glucosidase 0.1029 0.1319 0.1318
Brugia malayi intermediate filament protein 0.0052 0.0037 0.0032
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0127 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.1995 0.2588 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.764 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.0025 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0543 0.0682 0.0682
Echinococcus multilocularis cpg binding protein 0.0029 0.0007 0.0006
Trichomonas vaginalis trehalase, putative 0.013 0.0138 0.0513
Brugia malayi 6-phosphofructokinase 0.0107 0.0108 0.0103
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0033 0.0081
Schistosoma mansoni alpha glucosidase 0.1995 0.2588 0.2937
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0033 0.0032
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0049 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.1995 0.2588 1
Echinococcus granulosus intermediate filament protein 0.0052 0.0037 0.0035
Toxoplasma gondii melibiase subfamily protein 0.0364 0.0446 0.1704
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0031 0.0031
Schistosoma mansoni alpha-amylase 0.0072 0.0063 0.0066
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0049 0.0049
Trichomonas vaginalis glycoside hydrolases, putative 0.0394 0.0486 0.1859
Onchocerca volvulus 0.013 0.0138 0.0197
Brugia malayi hypothetical protein 0.0045 0.0027 0.0022
Loa Loa (eye worm) transcription factor SMAD2 0.0108 0.011 0.011
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0038 0.0122
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0033 0.0012 0.5
Brugia malayi Trehalase family protein 0.0045 0.0027 0.0022
Schistosoma mansoni inositol monophosphatase 0.0033 0.0012 0.0008
Brugia malayi hypothetical protein 0.0045 0.0027 0.0022
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.1995 0.2588 0.2588
Brugia malayi MAP kinase sur-1 0.0049 0.0033 0.0028
Brugia malayi Amylo-alpha-1,6-glucosidase family protein 0.0643 0.0812 0.0808
Trichomonas vaginalis glucosylceramidase, putative 0.067 0.0848 0.3259
Onchocerca volvulus 0.013 0.0138 0.0197
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0033 0.0032
Schistosoma mansoni inositol monophosphatase 0.0033 0.0012 0.0008
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0108 0.0118
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0643 0.0812 0.3123
Trichomonas vaginalis alpha-glucosidase, putative 0.0885 0.1131 0.4356
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0006 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0706 0.0895 0.3443
Brugia malayi Trehalase family protein 0.0045 0.0027 0.0022
Trypanosoma brucei trypanothione reductase 0.0048 0.0031 0.0073
Leishmania major glycosyl hydrolase-like protein 0.0885 0.1131 0.4343
Trichomonas vaginalis alpha-glucosidase, putative 0.1995 0.2588 1
Trichomonas vaginalis glucosylceramidase, putative 0.067 0.0848 0.3259
Loa Loa (eye worm) hypothetical protein 0.013 0.0138 0.0138
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0108 0.0118
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0108 0.0374
Loa Loa (eye worm) hypothetical protein 0.0361 0.0443 0.0443
Trichomonas vaginalis conserved hypothetical protein 0.033 0.0401 0.1531
Trichomonas vaginalis alpha-L-fucosidase, putative 0.085 0.1084 0.4175
Trichomonas vaginalis glucosylceramidase, putative 0.1021 0.1309 0.5044
Brugia malayi 6-phosphofructokinase 0.0107 0.0108 0.0103
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0046 0.0029 0.0088
Loa Loa (eye worm) beta-glucuronidase 0.0327 0.0397 0.0397
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0046 0.0047
Echinococcus multilocularis musashi 0.0052 0.0037 0.0035
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0885 0.1131 0.4356
Trichomonas vaginalis maltase-glucoamylase, putative 0.0885 0.1131 0.4356
Schistosoma mansoni hypothetical protein 0.0124 0.013 0.0143
Giardia lamblia 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase 0.0643 0.0812 1
Echinococcus granulosus beta galactosidase 0.0361 0.0443 0.0441
Schistosoma mansoni intermediate filament proteins 0.0052 0.0037 0.0036
Echinococcus granulosus lamin dm0 0.0052 0.0037 0.0035
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0033 0.0081
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0885 0.1131 0.4343
Brugia malayi Trehalase family protein 0.013 0.0138 0.0134
Loa Loa (eye worm) hypothetical protein 0.0046 0.0029 0.0029
Loa Loa (eye worm) glutathione reductase 0.0048 0.0031 0.0031
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0364 0.0446 0.0502
Mycobacterium leprae Putative uncharacterized protein ML2045 0.0072 0.0063 0.4642
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0046 0.0029 0.0088
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0643 0.0812 0.3123
Loa Loa (eye worm) hypothetical protein 0.013 0.0138 0.0138
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.1995 0.2588 1
Schistosoma mansoni alpha-glucosidase 0.6728 0.8802 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0049 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.1021 0.1309 0.5044
Trichomonas vaginalis glucosylceramidase, putative 0.067 0.0848 0.3259
Trichomonas vaginalis alpha-glucosidase, putative 0.0885 0.1131 0.4356
Brugia malayi hypothetical protein 0.0045 0.0027 0.0022
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0055 0.0054
Brugia malayi Ceramide glucosyltransferase 0.1186 0.1526 0.1522
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0055 0.0058
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0108 0.0396
Echinococcus multilocularis bile acid beta glucosidase 0.1029 0.1319 0.1318
Onchocerca volvulus 0.0052 0.0037 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0049 0.005
Onchocerca volvulus 0.013 0.0138 0.0197
Entamoeba histolytica hypothetical protein 0.0032 0.001 0.0017
Trichomonas vaginalis Periplasmic beta-glucosidase precursor, putative 0.0032 0.001 0.0017
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.004 0.0021 0.0021
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.2444 0.3177 0.3176
Echinococcus granulosus inositol monophosphatase 1 0.0033 0.0012 0.0011
Brugia malayi Intermediate filament tail domain containing protein 0.0052 0.0037 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.067 0.0848 0.3259
Plasmodium falciparum thioredoxin reductase 0.0048 0.0031 0.2301
Trichomonas vaginalis beta-mannosidase, putative 0.0181 0.0207 0.0776
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0111 0.8666
Trichomonas vaginalis alpha-glucosidase, putative 0.0885 0.1131 0.4356
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0005 0.0005
Schistosoma mansoni alpha-amylase 0.0072 0.0063 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.067 0.0848 0.3259
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0031 0.1955
Trichomonas vaginalis alpha-glucosidase, putative 0.0885 0.1131 0.4356
Loa Loa (eye worm) hypothetical protein 0.0643 0.0812 0.0812
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0005 0.0005
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0364 0.0446 0.0502

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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