Detailed information for compound 951932

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 297.433 | Formula: C17H31NO3
  • H donors: 1 H acceptors: 2 LogP: 3.98 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCNC(=O)CCCCC1CCC(=O)O1
  • InChi: 1S/C17H31NO3/c1-2-3-4-5-6-9-14-18-16(19)11-8-7-10-15-12-13-17(20)21-15/h15H,2-14H2,1H3,(H,18,19)
  • InChiKey: UACZVTXRNSOKCS-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0425 0.3902 1
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.014 0.014
Trichomonas vaginalis histone deacetylase, putative 0.0073 0.0573 0.2168
Trypanosoma brucei histone deacetylase 1 0.0073 0.0573 0.0573
Entamoeba histolytica prolyl oligopeptidase family protein 0.0112 0.0938 0.3552
Loa Loa (eye worm) hypothetical protein 0.0464 0.4271 0.4271
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0425 0.3902 0.3902
Entamoeba histolytica hypothetical protein 0.0028 0.014 0.053
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0345 0.0308
Plasmodium falciparum histone deacetylase 2 0.0057 0.0413 0.4165
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0331 0.3012 0.2995
Entamoeba histolytica prolyl oligopeptidase family protein 0.0112 0.0938 0.3552
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.089 0.0941
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0345 0.0345
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0054 0.0054
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0054 0.0054
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1068 1 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0112 0.0938 0.0938
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0446 0.0409
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.014 0.0116
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0345 0.0345
Echinococcus multilocularis zinc finger protein 0.0022 0.0082 0.0044
Loa Loa (eye worm) ctsf protein 0.0017 0.0039 0.0039
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0345 0.3407
Trypanosoma cruzi kinesin, putative 0.0015 0.0015 0.0015
Schistosoma mansoni inositol monophosphatase 0.0118 0.0995 0.0973
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0196 0.1734 0.1734
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.014 0.014
Trichomonas vaginalis esterase, putative 0.0107 0.089 0.3371
Schistosoma mansoni rab6-interacting 0.0019 0.0057 0.0033
Echinococcus granulosus geminin 0.0331 0.3012 0.2985
Toxoplasma gondii histone deacetylase HDAC1 0.0057 0.0413 0.0376
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0028 0.014 0.0102
Plasmodium falciparum plasmepsin II 0.005 0.0354 0.3501
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.089 0.089
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.014 0.053
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.089 0.0941
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0075 0.0075
Trypanosoma brucei metacaspase MCA2 0.0028 0.014 0.014
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0441 0.0441
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0118 0.0995 0.0995
Onchocerca volvulus 0.0017 0.0039 0.0039
Brugia malayi histone deacetylase 11 0.0029 0.0154 0.0154
Leishmania major cathepsin L-like protease 0.0017 0.0039 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0495 0.0495
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0366 0.3348 0.3348
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0157 0.0119
Entamoeba histolytica hypothetical protein, conserved 0.0112 0.0938 0.3552
Trypanosoma cruzi oligopeptidase b 0.0425 0.3902 0.3902
Trichomonas vaginalis histone deacetylase, putative 0.0073 0.0573 0.2168
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.014 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0157 0.0132
Loa Loa (eye worm) hypothetical protein 0.0107 0.089 0.089
Echinococcus granulosus histone deacetylase 3 0.0073 0.0573 0.0536
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0112 0.0938 0.3552
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0209 0.079
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.014 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0146
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0116 0.0116
Trypanosoma brucei glucosidase, putative 0.0035 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0034 0.0201 0.0201
Schistosoma mansoni histone deacetylase hda2 0.0063 0.047 0.0446
Brugia malayi calpain 7 0.0021 0.0075 0.0075
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0112 0.0938 0.0903
Brugia malayi Cathepsin L-like precursor 0.0017 0.0039 0.0039
Echinococcus multilocularis histone deacetylase 1 0.0073 0.0573 0.0536
Trichomonas vaginalis set domain proteins, putative 0.023 0.206 0.7798
Onchocerca volvulus 0.0095 0.0773 0.0773
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0039 0.0146
Trypanosoma brucei histone deacetylase 2 0.0029 0.0154 0.0154
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0042 0.0003
Trypanosoma cruzi metacaspase, putative 0.0028 0.014 0.014
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0384 0.0346
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.1734 0.1714
Echinococcus granulosus snurportin 1 0.0366 0.3348 0.3322
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1374 0.134
Leishmania major importin beta-1 subunit, putative 0.0028 0.014 0.014
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0118 0.0995 0.0995
Schistosoma mansoni cpg binding protein 0.0034 0.0194 0.017
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0472 0.0435
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0075 0.0075
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0345 0.0345
Echinococcus granulosus calpain A 0.0021 0.0075 0.0037
Echinococcus granulosus acylamino acid releasing enzyme 0.0112 0.0938 0.0903
Toxoplasma gondii histone deacetylase HDAC5 0.0029 0.0154 0.0116
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0075 0.0051
Loa Loa (eye worm) cysteine protease 0.0017 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0039 0.0248 0.0248
Trypanosoma brucei prolyl endopeptidase 0.1068 1 1
Leishmania major cathepsin L-like protease 0.0017 0.0039 0.0039
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0209 0.079
Trichomonas vaginalis importin beta-1, putative 0.0028 0.014 0.053
Loa Loa (eye worm) histone deacetylase 0.0057 0.0413 0.0413
Trichomonas vaginalis histone deacetylase, putative 0.0073 0.0573 0.2168
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0054 0.0016
Loa Loa (eye worm) aspartic protease BmAsp-2 0.005 0.0354 0.0354
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0322 0.0285
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2641 1
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0112 0.0938 0.0938
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0039 0.0146
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0073 0.0573 0.2168
Entamoeba histolytica protein kinase, putative 0.0015 0.0015 0.0058
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.1374 0.134
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.014 0.053
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.014 0.053
Brugia malayi prolyl oligopeptidase family protein 0.0112 0.0938 0.0938
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.005 0.0354 0.0316
Echinococcus multilocularis cpg binding protein 0.0034 0.0194 0.0156
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0075 0.0075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0039 0.0146
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0075 0.0075
Entamoeba histolytica histone deacetylase, putative 0.0073 0.0573 0.2168
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0116 0.0116
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0106 0.0878 0.0927
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0039 0.0146
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0112 0.0938 0.3552
Schistosoma mansoni histone deacetylase 4 5 0.0057 0.0413 0.039
Schistosoma mansoni inositol monophosphatase 0.0118 0.0995 0.0973
Loa Loa (eye worm) prolyl oligopeptidase 0.0112 0.0938 0.0938
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0209 0.0209
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0683 0.6354 0.7092
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.089 0.0941
Trypanosoma brucei metacaspase MCA3 0.0028 0.014 0.014
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0116 0.0855
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.014 0.053
Loa Loa (eye worm) hypothetical protein 0.0033 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.0033
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0209 0.0209
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0427 0.0404
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.089 0.0941
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.014 0.053
Schistosoma mansoni hypothetical protein 0.0035 0.0207 0.0183
Loa Loa (eye worm) hypothetical protein 0.005 0.0354 0.0354
Plasmodium vivax SET domain protein, putative 0.003 0.0157 0.1313
Schistosoma mansoni histone deacetylase hda2 0.0029 0.0154 0.013
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0051 0.0051
Onchocerca volvulus 0.023 0.206 0.206
Brugia malayi Importin beta-1 subunit 0.0034 0.0201 0.0201
Loa Loa (eye worm) histone deacetylase 11 0.0029 0.0154 0.0154
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0425 0.3902 0.3902
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0054 0.0205
Trichomonas vaginalis histone deacetylase, putative 0.0073 0.0573 0.2168
Schistosoma mansoni histone deacetylase 1 2 3 0.0029 0.0154 0.013
Loa Loa (eye worm) inositol-1 0.0118 0.0995 0.0995
Brugia malayi calpain 5 0.0015 0.0015 0.0015
Schistosoma mansoni importin beta-1 0.0034 0.0201 0.0177
Toxoplasma gondii kringle domain-containing protein 0.0018 0.0051 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.089 0.3371
Onchocerca volvulus 0.0017 0.0039 0.0039
Onchocerca volvulus 0.003 0.0159 0.0159
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0042 0.0003
Loa Loa (eye worm) TK/ROR protein kinase 0.0018 0.0051 0.0051
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.1227 0.3047
Brugia malayi Kringle domain containing protein 0.0018 0.0051 0.0051
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0118 0.0995 1
Trypanosoma brucei metacaspase 5, putative 0.0028 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0107 0.089 0.089
Trypanosoma brucei kinesin, putative 0.0015 0.0015 0.0015
Plasmodium falciparum histone deacetylase, putative 0.0057 0.0413 0.4165
Toxoplasma gondii ABC1 family protein 0.0107 0.089 0.0855
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0111 0.0073
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0201 0.0201
Brugia malayi beta-lactamase family protein 0.0107 0.089 0.089
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0112 0.0938 0.0916
Schistosoma mansoni rab6-interacting 0.0019 0.0057 0.0033
Echinococcus multilocularis caspase 2 0.0028 0.014 0.0102
Schistosoma mansoni histone deacetylase 4 5 0.0057 0.0413 0.039
Echinococcus granulosus caspase 2 0.0028 0.014 0.0102
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0075 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0146
Mycobacterium tuberculosis Conserved protein 0.0107 0.089 0.0941
Onchocerca volvulus 0.0091 0.0742 0.0742
Trypanosoma brucei Metacaspase-4 0.0028 0.014 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.014 0.053
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0073 0.0573 0.2168
Toxoplasma gondii aspartyl protease ASP1 0.005 0.0354 0.0316
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0159 0.0159
Echinococcus multilocularis inositol monophosphatase 1 0.0118 0.0995 0.096
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0057 0.0019
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0075 0.0051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.1734 0.1702
Leishmania major metacaspase, putative 0.0028 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0056 0.0404 0.0404
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0054 0.0054
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0938 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.014 0.053
Brugia malayi histone deacetylase 3 (HD3) 0.0073 0.0573 0.0573
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0207 0.0169
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0495 0.0495
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0112 0.0938 0.0903
Brugia malayi hypothetical protein 0.0035 0.0207 0.0207
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0495 0.0495
Schistosoma mansoni alpha-glucosidase 0.0136 0.1165 0.1143
Trypanosoma cruzi ISWI complex protein 0.0016 0.0025 0.0025
Echinococcus granulosus calpain 0.0021 0.0075 0.0037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0487 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.014 0.053
Plasmodium vivax aspartyl proteinase, putative 0.005 0.0354 0.3501
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.089 0.0868
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0425 0.3902 0.3902
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0118 0.0995 0.3768
Plasmodium vivax histone deacetylase 1, putative 0.0073 0.0573 0.5937
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0054 0.0172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2641 1
Brugia malayi Pre-SET motif family protein 0.0202 0.1795 0.1795
Leishmania major cathepsin L-like protease 0.0017 0.0039 0.0039
Echinococcus granulosus histone deacetylase 6 0.0057 0.0413 0.0376
Giardia lamblia Histone deacetylase 0.0073 0.0573 0.2004
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.1227 0.1154
Trichomonas vaginalis ran, putative 0.0025 0.0116 0.0438
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0225 0.0187
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.089 0.089
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0209 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.014 0.053
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0039 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.089 0.3371
Plasmodium vivax calpain, putative 0.0021 0.0075 0.0406
Trypanosoma cruzi histone deacetylase, putative 0.0057 0.0413 0.0413
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0075 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0157 0.0132
Schistosoma mansoni histone deacetylase 0.0073 0.0573 0.0549
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2641 1
Brugia malayi prolyl oligopeptidase family protein 0.0112 0.0938 0.0938
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.1374 0.1374
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.014 0.053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0057 0.0057
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1795 0.1795
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0075 0.0075
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.089 0.0855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0146
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0075 0.0075
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0075 0.0075
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0042 0.0017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0196 0.1734 0.1734
Loa Loa (eye worm) hypothetical protein 0.0107 0.089 0.089
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0039 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0495 0.0495
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0075 0.0075
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0425 0.3902 0.3902
Leishmania major cathepsin L-like protease 0.0065 0.0495 0.0495
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0087 0.0048
Trypanosoma cruzi prolyl endopeptidase 0.1068 1 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0057 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0495 0.0495
Plasmodium falciparum importin beta, putative 0.0034 0.0201 0.181
Schistosoma mansoni hypothetical protein 0.0021 0.0076 0.0052
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0057 0.0209
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.1734 0.1714
Echinococcus multilocularis histone deacetylase 6 0.0057 0.0413 0.0376
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.005 0.0354 0.0316
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0112 0.0938 0.0938
Echinococcus multilocularis acylamino acid releasing enzyme 0.0112 0.0938 0.0903
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0039 0.0039
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0054 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0054 0.0205
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.089 0.089
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0118 0.0995 0.2445
Schistosoma mansoni cathepsin D (A01 family) 0.0148 0.1284 0.1262
Echinococcus granulosus histone deacetylase 1 0.0073 0.0573 0.0536
Brugia malayi hypothetical protein 0.0464 0.4271 0.4271
Trypanosoma cruzi metacaspase, putative 0.0028 0.014 0.014
Onchocerca volvulus 0.0107 0.089 0.089
Schistosoma mansoni bromodomain containing protein 0.0066 0.0506 0.0483
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.089 0.0941
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0039 0.0146
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.005 0.0354 0.033
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0028 0.014 0.0102
Echinococcus granulosus caspase 8 0.0028 0.014 0.0102
Plasmodium vivax hypothetical protein, conserved 0.0028 0.014 0.1126
Loa Loa (eye worm) hypothetical protein 0.0112 0.0938 0.0938
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.1734 0.1702
Brugia malayi hypothetical protein 0.0019 0.0057 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0322 0.0298
Leishmania major histone deacetylase, putative 0.0073 0.0573 0.0573
Brugia malayi hypothetical protein 0.0019 0.0057 0.0057
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0057 0.0057
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0209 0.017
Giardia lamblia Alanyl dipeptidyl peptidase 0.0112 0.0938 0.3417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0146
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0118 0.0995 0.3768
Trichomonas vaginalis histone deacetylase, putative 0.0073 0.0573 0.2168
Loa Loa (eye worm) fibroinase 0.0017 0.0039 0.0039
Echinococcus granulosus inositol monophosphatase 1 0.0118 0.0995 0.096
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.7329 0.7319
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0075 0.0037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2641 1
Onchocerca volvulus 0.0017 0.0039 0.0039
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.1227 0.132
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0157 0.0119
Plasmodium vivax metacaspase 1, putative 0.0028 0.014 0.1126
Echinococcus multilocularis hypothetical protein 0.0021 0.0075 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0938 0.0938
Plasmodium falciparum plasmepsin VI 0.005 0.0354 0.3501
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0495 0.0495
Plasmodium falciparum histone deacetylase 1 0.0073 0.0573 0.5937
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.1374 0.1374
Brugia malayi Cathepsin L-like precursor 0.0017 0.0039 0.0039
Brugia malayi hypothetical protein 0.0049 0.0345 0.0345
Toxoplasma gondii histone deacetylase HDAC3 0.0073 0.0573 0.0536
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0075 0.0075
Echinococcus granulosus survival motor neuron protein 1 0.0464 0.4271 0.4249
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0112 0.0938 0.0916
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.1734 0.1714
Echinococcus granulosus cpg binding protein 0.0034 0.0194 0.0156
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0075 0.0075
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.089 0.3371
Trichomonas vaginalis histone deacetylase, putative 0.0073 0.0573 0.2168
Schistosoma mansoni zinc finger protein 0.0022 0.0082 0.0058
Giardia lamblia Alanyl dipeptidyl peptidase 0.0112 0.0938 0.3417
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0118 0.0995 0.096
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.014 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2641 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.1734 0.1702
Mycobacterium tuberculosis Conserved protein 0.0107 0.089 0.0941
Echinococcus multilocularis histone deacetylase 0.0057 0.0413 0.0376
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0118 0.0995 0.3768
Schistosoma mansoni calpain (C02 family) 0.0021 0.0075 0.0051
Toxoplasma gondii prolyl endopeptidase 0.1068 1 1
Echinococcus multilocularis caspase 0.0028 0.014 0.0102
Toxoplasma gondii histone deacetylase HDAC4 0.0029 0.0154 0.0116
Schistosoma mansoni hypothetical protein 0.0331 0.3012 0.2995
Brugia malayi Histone deacetylase family protein 0.0057 0.0413 0.0413
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0054 0.0205
Onchocerca volvulus 0.0017 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0072 0.0562 0.0562
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0039 0.0039
Schistosoma mansoni survival motor neuron protein 0.0095 0.0773 0.075
Plasmodium vivax histone deacetylase 2, putative 0.0057 0.0413 0.4165
Mycobacterium tuberculosis Conserved protein 0.0107 0.089 0.0941
Echinococcus granulosus caspase 0.0028 0.014 0.0102
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0039 0.0039
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0209 0.079
Trypanosoma brucei ISWI complex protein 0.0016 0.0025 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0938 0.0938
Brugia malayi CXXC zinc finger family protein 0.003 0.0159 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0146
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0118 0.0995 0.0995
Leishmania major oligopeptidase b 0.0425 0.3902 0.3902
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2641 1
Schistosoma mansoni polycystin 1-related 0.0019 0.0057 0.0033
Plasmodium vivax plasmepsin IV, putative 0.005 0.0354 0.3501
Brugia malayi Cell death protein 3 precursor 0.0028 0.014 0.014
Trypanosoma brucei metacaspase 0.0028 0.014 0.014
Echinococcus multilocularis prolyl endopeptidase 0.1068 1 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0938 0.0938
Trypanosoma cruzi ISWI complex protein 0.0016 0.0025 0.0025
Mycobacterium leprae conserved hypothetical protein 0.0107 0.089 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.089 0.089
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0116 0.0116
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0322 0.0285
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0118 0.0995 0.0995
Echinococcus granulosus histone deacetylase 0.0057 0.0413 0.0376
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.2641 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0075 0.0075
Schistosoma mansoni ran 0.0025 0.0116 0.0091
Echinococcus granulosus calpain 5 0.0021 0.0075 0.0037
Loa Loa (eye worm) hypothetical protein 0.0035 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0107 0.089 0.089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0039 0.0146
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0051
Schistosoma mansoni lipoxygenase 0.0054 0.0384 0.036
Echinococcus granulosus zinc finger protein 0.0022 0.0082 0.0044
Loa Loa (eye worm) hypothetical protein 0.0028 0.014 0.014
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0116 0.0237
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0112 0.0938 0.0903
Trypanosoma brucei histone deacetylase 3 0.0057 0.0413 0.0413
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0209 0.017
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0057 0.0019
Echinococcus granulosus histone deacetylase 8 0.0029 0.0154 0.0116
Onchocerca volvulus 0.0018 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0018 0.0051 0.0027
Loa Loa (eye worm) hypothetical protein 0.0041 0.0264 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0495 0.0495
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0116 0.0116
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0116 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0146
Plasmodium falciparum plasmepsin I 0.005 0.0354 0.3501
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0209 0.079
Brugia malayi Protein kinase domain containing protein 0.0018 0.0051 0.0051
Onchocerca volvulus 0.0035 0.0205 0.0205
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0028 0.014 0.014
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0116 0.0855
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0087 0.0048
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.005 0.0354 0.1339
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0141 0.0102
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0054 0.0054
Brugia malayi prolyl oligopeptidase family protein 0.0112 0.0938 0.0938
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0209 0.079
Brugia malayi Cathepsin L-like precursor 0.0017 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.014 0.053
Brugia malayi Bromodomain containing protein 0.0078 0.062 0.062
Leishmania major cathepsin L-like protease 0.0017 0.0039 0.0039
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0018 0.0051 0.0138
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0773 0.0773
Schistosoma mansoni lipoxygenase 0.0019 0.0057 0.0033
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0039 0.0014
Loa Loa (eye worm) hypothetical protein 0.0107 0.089 0.089
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0345 0.3407
Brugia malayi Doublecortin family protein 0.0019 0.0057 0.0057
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0425 0.3902 0.4331
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0039 0.0146
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0042 0.0017
Echinococcus granulosus RUN 0.0019 0.0057 0.0019
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0209 0.079
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0495 0.0495
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.089 0.2173
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0075 0.0075
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0116 0.0077
Loa Loa (eye worm) hypothetical protein 0.0047 0.0322 0.0322
Leishmania major hypothetical protein, conserved 0.0018 0.0051 0.0051
Trypanosoma cruzi histone deacetylase, putative 0.0057 0.0413 0.0413
Entamoeba histolytica cysteine protease, putative 0.0017 0.0039 0.0146
Plasmodium falciparum metacaspase-like protein 0.0028 0.014 0.1126
Echinococcus multilocularis snurportin 1 0.0366 0.3348 0.3322
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0039 0.0146
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0075 0.0075
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0075 0.0075
Entamoeba histolytica hypothetical protein 0.0035 0.0207 0.0783
Toxoplasma gondii exonuclease III APE 0.0019 0.0054 0.0016
Brugia malayi beta-lactamase family protein 0.0107 0.089 0.089
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0039 0.0039
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.014 0.0102
Loa Loa (eye worm) calpain family protein 1 0.0041 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0028 0.014 0.014
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0209 0.079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0146
Loa Loa (eye worm) calpain 0.0021 0.0075 0.0075
Brugia malayi PHD-finger family protein 0.0027 0.0134 0.0134
Echinococcus multilocularis histone deacetylase 6 0.0063 0.047 0.0433
Brugia malayi calpain family protein 1 0.0056 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0029 0.0154 0.0154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2641 1
Echinococcus granulosus histone deacetylase 7 0.0057 0.0413 0.0376
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0039 0.0146
Schistosoma mansoni ap endonuclease 0.0019 0.0054 0.003
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0112 0.0938 0.3552
Brugia malayi Cathepsin L-like precursor 0.0017 0.0039 0.0039
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.014 0.053
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0207 0.0169
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0472 0.0435
Plasmodium vivax histone deacetylase, putative 0.0029 0.0154 0.1287
Entamoeba histolytica calpain large subunit domain III containing protein 0.0015 0.0015 0.0058
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0073 0.0573 0.2168
Trypanosoma brucei histone deacetylase, putative 0.0057 0.0413 0.0413
Plasmodium falciparum plasmepsin IV 0.005 0.0354 0.3501
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0058 0.0427 0.039
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.014 0.053
Leishmania major histone deacetylase, putative 0.0057 0.0413 0.0413
Loa Loa (eye worm) histone deacetylase 3 0.0073 0.0573 0.0573
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0201 0.0163
Trypanosoma cruzi histone deacetylase, putative 0.0029 0.0154 0.0154
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0111 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.089 0.089
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0075 0.0051
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.089 0.3371
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0075 0.0037
Onchocerca volvulus 0.0107 0.089 0.089
Mycobacterium ulcerans hypothetical protein 0.0107 0.089 0.2173
Loa Loa (eye worm) hypothetical protein 0.0049 0.0344 0.0344
Onchocerca volvulus Cell death protein 3 homolog 0.0028 0.014 0.014
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0112 0.0938 0.0938
Brugia malayi Histone deacetylase 1 0.0073 0.0573 0.0573
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0112 0.0938 0.3552
Loa Loa (eye worm) hypothetical protein 0.0049 0.0345 0.0345
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.014 0.053
Echinococcus multilocularis caspase 8 0.0028 0.014 0.0102
Echinococcus multilocularis histone deacetylase 3 0.0073 0.0573 0.0536
Trypanosoma cruzi oligopeptidase b 0.0425 0.3902 0.3902
Leishmania major hypothetical protein, conserved 0.0049 0.0345 0.0345
Schistosoma mansoni alpha glucosidase 0.0035 0.0209 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0057 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2641 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0146
Entamoeba histolytica prolyl oligopeptidase family protein 0.0112 0.0938 0.3552
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0956 0.8938 1
Brugia malayi Inositol-1 0.0118 0.0995 0.0995
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.014 0.014
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0112 0.0938 0.0938
Trypanosoma cruzi histone deacetylase, putative 0.0057 0.0413 0.0413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0495 0.0495
Schistosoma mansoni loxhd1 0.0019 0.0057 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.1616 0.6118
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0054 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0209 0.0209
Plasmodium falciparum cysteine repeat modular protein 1 0.0018 0.0051 0.0138
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0028 0.014 0.0116
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0225 0.0187
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0209 0.079
Loa Loa (eye worm) beta-lactamase 0.0107 0.089 0.089
Trypanosoma brucei antigen, putative 0.0021 0.0075 0.0075
Echinococcus granulosus importin subunit beta 1 0.0034 0.0201 0.0163
Brugia malayi hypothetical protein 0.0032 0.0179 0.0179
Echinococcus multilocularis calpain 5 0.0021 0.0075 0.0037
Echinococcus granulosus tissue type plasminogen activator 0.0018 0.0051 0.0012
Brugia malayi calpain family protein 1 0.0056 0.0404 0.0404
Brugia malayi Bromodomain containing protein 0.0039 0.0248 0.0248
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1068 1 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0073 0.0573 0.0573
Onchocerca volvulus 0.0017 0.0039 0.0039
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1068 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.014 0.053
Leishmania major kinesin, putative 0.0015 0.0015 0.0015
Mycobacterium ulcerans beta-lactamase 0.0107 0.089 0.2173
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0057 0.0209
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0039 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0495 0.0495
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0495 0.0495
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.089 0.0941
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0146
Schistosoma mansoni ran 0.0025 0.0116 0.0091
Echinococcus multilocularis histone deacetylase 8 0.0029 0.0154 0.0116
Leishmania major hypothetical protein, conserved 0.0107 0.089 0.089
Echinococcus multilocularis calpain A 0.0058 0.0427 0.039
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0209 0.079
Trypanosoma brucei prolyl oligopeptidase, putative 0.0425 0.3902 0.3902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0039 0.0146
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.089 0.0941
Echinococcus multilocularis tissue type plasminogen activator 0.0018 0.0051 0.0012
Leishmania major hypothetical protein, conserved 0.0016 0.0025 0.0025
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0075 0.0075
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0112 0.0938 0.0938
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0039 0.0146
Entamoeba histolytica Ran family GTPase 0.0025 0.0116 0.0438
Entamoeba histolytica hypothetical protein 0.0035 0.0207 0.0783
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0425 0.3902 1
Schistosoma mansoni histone deacetylase 0.0073 0.0573 0.0549
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0112 0.0938 0.0938
Schistosoma mansoni cpg binding protein 0.003 0.0159 0.0135
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0054 0.0172
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.0135
Entamoeba histolytica hypothetical protein 0.0035 0.0207 0.0783
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1374 0.134
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0076 0.0076
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0363 0.0363
Plasmodium vivax histone deacetylase, putative 0.0057 0.0413 0.4165
Onchocerca volvulus 0.0019 0.0057 0.0057
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0207 0.0183
Trypanosoma cruzi histone deacetylase 1, putative 0.0073 0.0573 0.0573
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0057 0.0019
Trypanosoma brucei histone deacetylase 4 0.0057 0.0413 0.0413
Schistosoma mansoni hypothetical protein 0.0095 0.0773 0.075
Echinococcus granulosus calpain A 0.0058 0.0427 0.039
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.2641 1
Schistosoma mansoni cathepsin D (A01 family) 0.0148 0.1284 0.1262
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0039 0.0146
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0112 0.0938 0.0916
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.2641 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.1665 0.1665
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0112 0.0938 0.0916
Trichomonas vaginalis inositol monophosphatase, putative 0.0118 0.0995 0.3768
Loa Loa (eye worm) hypothetical protein 0.0107 0.089 0.089
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0054 0.0054
Echinococcus multilocularis histone deacetylase 7 0.0057 0.0413 0.0376
Loa Loa (eye worm) histone deacetylase 1 0.0073 0.0573 0.0573
Loa Loa (eye worm) calpain 5 0.0015 0.0015 0.0015
Brugia malayi histone deacetylase 1 (HD1) 0.0073 0.0573 0.0573
Schistosoma mansoni caspase-3 (C14 family) 0.0028 0.014 0.0116
Trypanosoma cruzi kinesin, putative 0.0015 0.0015 0.0015
Leishmania major histone deacetylase, putative 0.0073 0.0573 0.0573
Toxoplasma gondii hypothetical protein 0.0112 0.0938 0.0903
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0112 0.0938 0.0903
Leishmania major histone deacetylase, putative 0.0057 0.0413 0.0413
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0209 0.079
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0075 0.0075
Brugia malayi prolyl oligopeptidase family protein 0.0112 0.0938 0.0938
Trypanosoma cruzi metacaspase, putative 0.0028 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0146
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0116 0.0077
Schistosoma mansoni hypothetical protein 0.0366 0.3348 0.3331
Echinococcus multilocularis survival motor neuron protein 1 0.0464 0.4271 0.4249
Onchocerca volvulus Prolyl endopeptidase homolog 0.1068 1 1
Leishmania major cathepsin L-like protease 0.0065 0.0495 0.0495
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0938 0.3552
Plasmodium vivax importin-beta 2, putative 0.0034 0.0201 0.181
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.1734 0.1702
Plasmodium vivax hypothetical protein, conserved 0.0107 0.089 0.9468
Leishmania major cathepsin L-like protease 0.0017 0.0039 0.0039
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0039 0.0039
Echinococcus multilocularis calpain family protein 1, d 0.0041 0.0264 0.0227
Brugia malayi Cathepsin L-like precursor 0.0017 0.0039 0.0039
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0384 0.0346
Plasmodium falciparum peptidase, putative 0.0112 0.0938 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0573 0.0573
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.089 0.2173
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.089 0.0855
Loa Loa (eye worm) hypothetical protein 0.0042 0.0271 0.0271
Brugia malayi RNA, U transporter 1 0.0098 0.0801 0.0801
Entamoeba histolytica hypothetical protein 0.0035 0.0207 0.0783
Onchocerca volvulus 0.0017 0.0039 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0495 0.0495
Onchocerca volvulus 0.0107 0.089 0.089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0146
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.005 0.0354 0.0316
Loa Loa (eye worm) hypothetical protein 0.0045 0.0306 0.0306
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0146
Onchocerca volvulus Histone deacetylase 10 homolog 0.0029 0.0154 0.0154
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.1068 1 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.2641 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0201 0.0201
Plasmodium falciparum metacaspase 1 0.0028 0.014 0.1126
Brugia malayi Pre-SET motif family protein 0.003 0.0157 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0495 0.0495
Onchocerca volvulus 0.0017 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0022 0.0087 0.0062
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0209 0.0209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0495 0.0495
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0058 0.0427 0.039
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0189 0.1665 0.1665
Echinococcus granulosus prolyl endopeptidase 0.1068 1 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0209 0.017
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0404 0.038
Brugia malayi Cathepsin L-like precursor 0.0017 0.0039 0.0039
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0039 0.0146
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0345 0.3407
Onchocerca volvulus 0.003 0.0157 0.0157
Schistosoma mansoni alpha-glucosidase 0.0136 0.1165 0.1143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0039 0.0146
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.014 0.0102
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0057 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0322 0.0298
Mycobacterium tuberculosis Probable peptidase 0.0425 0.3902 0.4331
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Brugia malayi beta-lactamase 0.0107 0.089 0.089
Trypanosoma cruzi histone deacetylase, putative 0.0029 0.0154 0.0154
Onchocerca volvulus 0.0019 0.0057 0.0057
Trypanosoma brucei oligopeptidase b 0.0425 0.3902 0.3902
Schistosoma mansoni ap endonuclease 0.0019 0.0054 0.003
Echinococcus multilocularis histone deacetylase 6 0.0057 0.0413 0.0376
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.014 0.053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.089 0.0868
Mycobacterium ulcerans lipase LipD 0.0107 0.089 0.2173
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0427 0.0404
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0201 0.0163
Loa Loa (eye worm) calpain family protein 1 0.0056 0.0404 0.0404
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0075 0.0051
Trypanosoma cruzi metacaspase, putative 0.0028 0.014 0.014
Toxoplasma gondii histone deacetylase HDAC2 0.0073 0.0573 0.0536
Loa Loa (eye worm) prolyl oligopeptidase 0.0112 0.0938 0.0938
Echinococcus granulosus histone deacetylase 6 0.0057 0.0413 0.0376
Leishmania major cathepsin L-like protease 0.0065 0.0495 0.0495
Schistosoma mansoni cpg binding protein 0.0034 0.0194 0.017
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0112 0.0938 0.0903
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.089 0.3371
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0111 0.0073
Mycobacterium leprae Probable lipase LipE 0.0107 0.089 0.0041
Echinococcus multilocularis RUN 0.0019 0.0057 0.0019
Loa Loa (eye worm) histone deacetylase 7A 0.0057 0.0413 0.0413
Echinococcus granulosus histone deacetylase 6 0.0063 0.047 0.0433
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0116 0.0077
Echinococcus granulosus Dipeptidyl peptidase 9 0.0112 0.0938 0.0903
Leishmania major GTP-binding protein, putative 0.0025 0.0116 0.0116
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0057 0.0019
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0209 0.079
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0495 0.0495
Echinococcus multilocularis calpain 0.0021 0.0075 0.0037
Brugia malayi Histone deacetylase family protein 0.0057 0.0413 0.0413
Echinococcus multilocularis geminin 0.0331 0.3012 0.2985

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 128 uM Antitubercular activity against Mycobacterium tuberculosis H37Rv after 4 days by microplate alamar blue assay ChEMBL. 18774716

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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