Detailed information for compound 991361

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.227 | Formula: C18H15BrN2O4
  • H donors: 3 H acceptors: 3 LogP: 3.27 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1O)CN/C=C/1\C(=O)NC(=O)c2c1c(Br)ccc2
  • InChi: 1S/C18H15BrN2O4/c1-25-15-6-5-10(7-14(15)22)8-20-9-12-16-11(3-2-4-13(16)19)17(23)21-18(12)24/h2-7,9,20,22H,8H2,1H3,(H,21,23,24)/b12-9-
  • InChiKey: CSOPPVQBDUVTEY-XFXZXTDPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin B1 References
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References
Homo sapiens cyclin D1 References
Homo sapiens cyclin-dependent kinase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 4 303 aa 312 aa 29.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear receptor NHR-67 0.0045 0.0747 0.0757
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0096 0.1665 0.1687
Echinococcus granulosus smad 0.0008 0.0072 0.008
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0072 0.0073
Onchocerca volvulus Protein CNPPD1 homolog 0.001 0.0116 0.0219
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.0889 0.5492
Onchocerca volvulus 0.0295 0.5272 1
Toxoplasma gondii cyclin dependent kinase binding protein 0.001 0.0116 0.1137
Brugia malayi nuclear hormone receptor family member nhr-6 0.0045 0.0747 0.0757
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0822 0.0832
Echinococcus granulosus nuclear receptor nhr 48 0.0045 0.0747 0.0835
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0889 0.5145
Echinococcus multilocularis cyclin y 0.001 0.0116 0.0395
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0034 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1348 0.3164
Schistosoma mansoni hypothetical protein 0.0016 0.0211 0.072
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.0889 0.3039
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0107 0.0664
Loa Loa (eye worm) hypothetical protein 0.0051 0.0845 0.0857
Loa Loa (eye worm) hypothetical protein 0.0034 0.0539 0.0546
Loa Loa (eye worm) hypothetical protein 0.0073 0.125 0.1266
Echinococcus multilocularis expressed protein 0.0033 0.0518 0.1773
Loa Loa (eye worm) hypothetical protein 0.0045 0.0747 0.0757
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0047 0.0772 0.264
Brugia malayi tailless protein 0.0045 0.0747 0.0757
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.1618 0.307
Brugia malayi MH2 domain containing protein 0.0116 0.2039 0.2066
Echinococcus multilocularis cyclin G2 0.001 0.0116 0.0395
Schistosoma mansoni cyclin k 0.001 0.0116 0.0395
Trichomonas vaginalis cyclins, putative 0.004 0.066 0.1499
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0096 0.1665 0.1687
Loa Loa (eye worm) hypothetical protein 0.0009 0.0085 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0117
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0555 1 1
Entamoeba histolytica cyclin, domain containing protein 0.001 0.0116 0.0606
Loa Loa (eye worm) hypothetical protein 0.003 0.0472 0.0478
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.004 0.0132
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0321 0.1414
Schistosoma mansoni tsg101-related 0.0056 0.0952 0.3255
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0096 0.1665 0.1687
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0134 0.0825
Echinococcus granulosus expressed protein 0.0033 0.0518 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1348 0.3164
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0096 0.1665 0.1687
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1618 0.3818
Brugia malayi Cyclin, N-terminal domain containing protein 0.0043 0.0706 0.0715
Trichomonas vaginalis cyclins, putative 0.001 0.0116 0.0183
Echinococcus multilocularis son of sevenless 1 0.0006 0.004 0.0136
Giardia lamblia NADPH oxidoreductase, putative 0.0078 0.1348 0.82
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0993 0.2306
Brugia malayi nuclear hormone receptor 0.0045 0.0747 0.0757
Echinococcus multilocularis Cyclin L1 0.001 0.0116 0.0395
Echinococcus multilocularis thyroid hormone receptor alpha 0.0096 0.1665 0.5693
Loa Loa (eye worm) hypothetical protein 0.0049 0.0822 0.0832
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0045 0.0747 0.2555
Echinococcus granulosus cyclin dependent kinase 0.0053 0.0889 0.0993
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0107 0.0664
Schistosoma mansoni thyroid hormone receptor 0.0096 0.1665 0.5693
Trypanosoma brucei beta lactamase 0.0062 0.1054 0.6266
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0211 0.0213
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0096 0.1665 0.5693
Trichomonas vaginalis set domain proteins, putative 0.0234 0.4174 1
Schistosoma mansoni hypothetical protein 0.0165 0.2924 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.004 0.0132
Onchocerca volvulus 0.0096 0.1665 0.3158
Giardia lamblia G2/mitotic-specific cyclin B 0.0073 0.125 0.7546
Onchocerca volvulus 0.0045 0.0747 0.1417
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.004 0.0136
Plasmodium vivax protein kinase Crk2 0.0053 0.0889 1
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0047 0.0772 0.0782
Loa Loa (eye worm) hypothetical protein 0.0096 0.1665 0.1687
Loa Loa (eye worm) hypothetical protein 0.0096 0.1665 0.1687
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0096 0.1665 0.186
Echinococcus granulosus cyclin 0.001 0.0116 0.0129
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1016 0.3476
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.1598 0.5464
Schistosoma mansoni kinase 0.0048 0.0797 0.2725
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0068 0.1157 0.1293
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0134 0.0825
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0645 0.7253
Brugia malayi hypothetical protein 0.0036 0.0575 0.0583
Echinococcus granulosus cyclin b3 0.0043 0.0706 0.0788
Loa Loa (eye worm) hypothetical protein 0.0045 0.0747 0.0757
Toxoplasma gondii hypothetical protein 0.0009 0.0085 0.0836
Giardia lamblia Hypothetical protein 0.0043 0.0706 0.3926
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.1618 0.164
Entamoeba histolytica cyclin C, putative 0.001 0.0116 0.0606
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0078 0.1348 0.3164
Loa Loa (eye worm) hypothetical protein 0.0045 0.0747 0.0757
Schistosoma mansoni retinoic acid receptor RXR 0.0096 0.1665 0.5693
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.312 0.5918
Echinococcus multilocularis GPCR, family 2 0.0016 0.0211 0.072
Echinococcus granulosus cyclins 0.001 0.0116 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0134 0.0227
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0748 0.2558
Echinococcus granulosus geminin 0.0165 0.2924 0.3266
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1618 0.3818
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0051 0.0845 0.0857
Loa Loa (eye worm) hypothetical protein 0.0176 0.312 0.3161
Loa Loa (eye worm) hypothetical protein 0.0051 0.0845 0.0857
Schistosoma mansoni cyclins 0.0043 0.0706 0.2413
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1016 1
Brugia malayi RasGEF domain containing protein 0.0006 0.004 0.004
Echinococcus granulosus cyclin G2 0.001 0.0116 0.0129
Schistosoma mansoni nuclear receptor nhr-48 0.0045 0.0747 0.2555
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.0587
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.004 0.0132
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.004 0.0132
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0555 1 1
Echinococcus granulosus Protein son of sevenless 0.0006 0.004 0.0045
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0096 0.1665 0.186
Entamoeba histolytica hypothetical protein 0.0035 0.0564 0.3409
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Loa Loa (eye worm) cyclin domain-containing protein 0.001 0.0116 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0096 0.1665 0.1687
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0085 0.0086
Loa Loa (eye worm) hypothetical protein 0.0045 0.0747 0.0757
Brugia malayi nuclear receptor RXR 0.0045 0.0747 0.0757
Trichomonas vaginalis rotamase, putative 0.0032 0.0505 0.1124
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0096 0.1665 0.5693
Brugia malayi Cyclin, N-terminal domain containing protein 0.001 0.0116 0.0117
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0085 0.0291
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0085 0.0291
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0564 0.063
Leishmania major protein kinase, putative 0.0005 0.0022 0.0138
Brugia malayi MH2 domain containing protein 0.0008 0.0072 0.0073
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0518 0.0525
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.001 0.0116 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0096 0.1665 0.1687
Entamoeba histolytica cyclin, putative 0.0043 0.0706 0.4294
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.002 0.0283 0.0587
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0096 0.1665 0.5693
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.001 0.0116 0.0395
Loa Loa (eye worm) hypothetical protein 0.001 0.0116 0.0117
Brugia malayi MH1 domain containing protein 0.0008 0.0072 0.0073
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.0889 0.09
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1348 0.3164
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0096 0.1665 0.5693
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1618 0.3818
Onchocerca volvulus Bile acid receptor homolog 0.0096 0.1665 0.3158
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0518 0.1158
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0747 0.2555
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0747 0.2555
Echinococcus multilocularis cyclin b3 0.0043 0.0706 0.2413
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.004 0.0132
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0645 0.0653
Toxoplasma gondii hypothetical protein 0.0033 0.0518 0.5096
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.001 0.0116 0.13
Schistosoma mansoni hypothetical protein 0.0034 0.0539 0.1842
Loa Loa (eye worm) hypothetical protein 0.0045 0.0747 0.0757
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0845 0.0857
Brugia malayi Cyclin, N-terminal domain containing protein 0.001 0.0116 0.0117
Brugia malayi Cyclin, N-terminal domain containing protein 0.001 0.0116 0.0117
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0107 0.0664
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0889 0.2053
Schistosoma mansoni cyclin G 0.001 0.0116 0.0395
Echinococcus granulosus cyclin G2 0.001 0.0116 0.0129
Onchocerca volvulus 0.0006 0.004 0.0076
Brugia malayi Cyclin, N-terminal domain containing protein 0.001 0.0116 0.0117
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.001 0.0116 0.13
Trypanosoma cruzi cyclin 9, putative 0.001 0.0116 0.0714
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0747 0.2555
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Brugia malayi hypothetical protein 0.001 0.0116 0.0117
Leishmania major cyclin 9, putative 0.001 0.0116 0.0714
Schistosoma mansoni hypothetical protein 0.004 0.0645 0.2204
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0085 0.0291
Echinococcus granulosus cyclins 0.0043 0.0706 0.0788
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2039 0.2066
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.1618 0.1808
Brugia malayi hypothetical protein 0.0045 0.0747 0.0757
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0096 0.1665 0.1687
Schistosoma mansoni hypothetical protein 0.0016 0.0211 0.072
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0096 0.1665 0.1687
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1016 0.3476
Trypanosoma cruzi mitotic cyclin, putative 0.001 0.0116 0.0714
Loa Loa (eye worm) hypothetical protein 0.0006 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0096 0.1665 0.1687
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0645 0.7253
Echinococcus multilocularis cyclin y 0.001 0.0116 0.0395
Schistosoma mansoni rotamase 0.0033 0.0518 0.1773
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.1618 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0748 0.2558
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0645 0.6342
Schistosoma mansoni hypothetical protein 0.0092 0.1602 0.548
Trichomonas vaginalis cyclins, putative 0.0043 0.0706 0.161
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0096 0.1665 0.186
Echinococcus multilocularis Smad4 0.0008 0.0072 0.0245
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0085 0.0095
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Loa Loa (eye worm) cyclin domain-containing protein 0.001 0.0116 0.0117
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.002 0.0283 0.0587
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0096 0.1665 0.5693
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.004 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.0587
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.004 0.0132
Brugia malayi hypothetical protein 0.0295 0.5272 0.5341
Trichomonas vaginalis cyclin B3, putative 0.001 0.0116 0.0183
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0134 0.0825
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.0587
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0051 0.0845 0.2891
Brugia malayi steroid hormone receptor 0.0548 0.987 1
Loa Loa (eye worm) nuclear factor I 0.0004 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1348 0.3164
Schistosoma mansoni RAR-like nuclear receptor 0.0096 0.1665 0.5693
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0211 0.0213
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Trypanosoma cruzi cyclin, putative 0.0073 0.125 0.7722
Brugia malayi hypothetical protein 0.0035 0.0564 0.0571
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.0889 0.0993
Echinococcus multilocularis cyclins 0.0043 0.0706 0.2413
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.0889 0.5171
Onchocerca volvulus 0.001 0.0116 0.0219
Onchocerca volvulus 0.0073 0.125 0.237
Brugia malayi hypothetical protein 0.0009 0.0085 0.0086
Loa Loa (eye worm) hypothetical protein 0.0051 0.0845 0.0857
Echinococcus granulosus Smad4 0.0008 0.0072 0.008
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Trichomonas vaginalis cyclin A, putative 0.001 0.0116 0.0183
Echinococcus granulosus cGMP dependent protein kinase 0.0005 0.0022 0.0025
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0134 0.0173
Loa Loa (eye worm) hypothetical protein 0.0096 0.1665 0.1687
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0116 0.0183
Loa Loa (eye worm) hypothetical protein 0.0045 0.0747 0.0757
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0564 0.1929
Brugia malayi Nuclear hormone receptor-like 1 0.0096 0.1665 0.1687
Plasmodium vivax SET domain protein, putative 0.0029 0.0463 0.521
Loa Loa (eye worm) CYL-1 protein 0.001 0.0116 0.0117
Echinococcus granulosus cyclin y 0.001 0.0116 0.0129
Schistosoma mansoni cyclin B 0.0073 0.125 0.4273
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0085 0.0291
Schistosoma mansoni smad1 5 8 and 0.0008 0.0072 0.0245
Loa Loa (eye worm) hypothetical protein 0.0096 0.1665 0.1687
Brugia malayi MH1 domain containing protein 0.0004 0.0007 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0096 0.1665 0.186
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0748 0.0835
Loa Loa (eye worm) hypothetical protein 0.0045 0.0747 0.0757
Brugia malayi Smad1 0.0008 0.0072 0.0073
Plasmodium vivax cyclin 4, putative 0.001 0.0116 0.13
Echinococcus granulosus G1:S specific cyclin D1 0.001 0.0116 0.0129
Brugia malayi Protein kinase domain containing protein 0.0053 0.0889 0.09
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.001 0.0116 0.0117
Schistosoma mansoni hypothetical protein 0.0165 0.2924 1
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0005 0.0022 0.022
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.004 0.0132
Echinococcus multilocularis nuclear receptor nhr 48 0.0045 0.0747 0.2555
Echinococcus multilocularis smad 0.0008 0.0072 0.0245
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1618 0.3818
Leishmania major mitotic cyclin, putative 0.001 0.0116 0.0714
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0062 0.1054 0.1054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0096 0.1665 0.5693
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0748 0.2558
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0072 0.0245
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0022 0.0077
Giardia lamblia NADPH oxidoreductase, putative 0.0078 0.1348 0.82
Plasmodium falciparum cGMP-dependent protein kinase 0.0005 0.0022 0.0252
Echinococcus granulosus kelch ECH associated protein 1 0.0092 0.1598 0.1785
Trichomonas vaginalis cyclin B3, putative 0.0043 0.0706 0.161
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.001 0.0116 0.13
Entamoeba histolytica hypothetical protein 0.0006 0.004 0.0132
Brugia malayi hypothetical protein 0.0051 0.0845 0.0857
Brugia malayi hypothetical protein 0.0051 0.0845 0.0857
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1016 0.1016
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0747 0.1417
Trichomonas vaginalis cyclins, putative 0.0073 0.125 0.2926
Schistosoma mansoni tsg101-related 0.0056 0.0952 0.3255
Trichomonas vaginalis cyclin B, putative 0.001 0.0116 0.0183
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.002 0.0283 0.165
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1016 0.1016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0096 0.1665 0.5693
Entamoeba histolytica cyclin, putative 0.0073 0.125 0.7695
Brugia malayi N-terminal motif family protein 0.0006 0.004 0.004
Loa Loa (eye worm) DR-78 0.0045 0.0747 0.0757
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0046 0.0764 0.4661
Echinococcus multilocularis Kelch repeat type 1 0.0092 0.1602 0.548
Echinococcus multilocularis cyclins 0.0043 0.0706 0.2413
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0889 0.2053
Brugia malayi hypothetical protein 0.0036 0.0575 0.0583
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0078 0.1348 0.3164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0096 0.1665 0.1687
Brugia malayi photoreceptor-specific nuclear receptor 0.0096 0.1665 0.1687
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2039 0.2066
Onchocerca volvulus Protein ultraspiracle homolog 0.0096 0.1665 0.3158
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0748 0.2558
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0096 0.1665 0.186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0096 0.1665 0.1687
Schistosoma mansoni cyclin B3 0.0043 0.0706 0.2413
Brugia malayi hypothetical protein 0.0045 0.0747 0.0757
Brugia malayi Pre-SET motif family protein 0.0206 0.3659 0.3707
Echinococcus multilocularis cyclins 0.0043 0.0706 0.2413
Loa Loa (eye worm) hypothetical protein 0.0068 0.1157 0.1173
Echinococcus granulosus cyclin k 0.001 0.0116 0.0129
Trichomonas vaginalis rotamase, putative 0.0033 0.0518 0.1158
Brugia malayi Cyclin C 0.001 0.0116 0.0117
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.004 0.0132
Leishmania major hypothetical protein, conserved 0.0022 0.0321 0.1984
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0645 0.0653
Echinococcus granulosus cyclin t1 0.001 0.0116 0.0129
Brugia malayi nuclear receptor NHR-67 0.0045 0.0747 0.0757
Trichomonas vaginalis cyclins, putative 0.0073 0.125 0.2926
Trypanosoma cruzi cyclin 6, putative 0.0073 0.125 0.7722
Echinococcus granulosus ecdysone induced protein 78C 0.0096 0.1665 0.186
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0096 0.1665 0.5693
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0116 0.0183
Schistosoma mansoni g1/s-specific cyclin C 0.001 0.0116 0.0395
Brugia malayi hypothetical protein 0.0068 0.1157 0.1173
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0211 0.0235
Brugia malayi N-terminal motif family protein 0.0176 0.312 0.3161
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0006 0.004 0.0246
Echinococcus multilocularis cyclin B 0.0073 0.125 0.4273
Onchocerca volvulus Cyclin L homolog 0.001 0.0116 0.0219
Brugia malayi Cyclin, N-terminal domain containing protein 0.001 0.0116 0.0117
Brugia malayi Cyclin, N-terminal domain containing protein 0.001 0.0116 0.0117
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.004 0.0136
Brugia malayi Egg laying defective protein 4 0.0005 0.0022 0.0023
Schistosoma mansoni cyclin l 0.001 0.0116 0.0395
Entamoeba histolytica hypothetical protein 0.0011 0.0134 0.0718
Loa Loa (eye worm) hypothetical protein 0.0045 0.0747 0.0757
Echinococcus granulosus thyroid hormone receptor alpha 0.0497 0.8952 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0096 0.1665 0.3158
Entamoeba histolytica modulator of drug activity B homolog, putative 0.002 0.0283 0.165
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Echinococcus granulosus oligomeric golgi complex subunit 3 0.001 0.0116 0.0129
Schistosoma mansoni hypothetical protein 0.0035 0.0564 0.1929
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0463 0.1583
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.004 0.004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0051 0.0845 0.2891
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1348 0.3164
Loa Loa (eye worm) hypothetical protein 0.0045 0.0747 0.0757
Echinococcus multilocularis cyclin A3 4 0.001 0.0116 0.0395
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.004 0.0132
Schistosoma mansoni Cyclin fold protein 0.001 0.0116 0.0395
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0096 0.1665 0.5693
Loa Loa (eye worm) cyclin domain-containing protein 0.0043 0.0706 0.0715
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0096 0.1665 0.5693
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0747 0.0835
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.004 0.0132
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Loa Loa (eye worm) hypothetical protein 0.0045 0.0747 0.0757
Loa Loa (eye worm) Smad1 0.0008 0.0072 0.0073
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0889 0.09
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0072 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1618 0.3818
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0747 0.0835
Echinococcus granulosus cyclin A3 4 0.001 0.0116 0.0129
Loa Loa (eye worm) hypothetical protein 0.0009 0.0085 0.0086
Echinococcus granulosus cyclins 0.0043 0.0706 0.0788
Echinococcus multilocularis cyclin G2 0.001 0.0116 0.0395
Schistosoma mansoni tsg101-related 0.0046 0.0764 0.2614
Loa Loa (eye worm) cyclin domain-containing protein 0.001 0.0116 0.0117
Echinococcus granulosus son of sevenless 1 0.0006 0.004 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1348 0.3164
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0822 0.0832
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0889 0.5492
Schistosoma mansoni dishevelled 0.0009 0.0085 0.0291
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1348 0.3164
Loa Loa (eye worm) hypothetical protein 0.0045 0.0747 0.0757
Brugia malayi cyclin fold protein 1 variant b 0.001 0.0116 0.0117
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.1618 0.5534
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0463 0.1583
Brugia malayi MH1 domain containing protein 0.0008 0.0072 0.0073
Trypanosoma brucei cyclin 3 0.001 0.0116 0.0054
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0085 0.0095
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0889 0.5439
Entamoeba histolytica hypothetical protein 0.001 0.0116 0.0606
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0889 0.5145
Trichomonas vaginalis cyclins, putative 0.0073 0.125 0.2926
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0096 0.1665 0.1687
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1348 0.3164
Plasmodium vivax cyclin homologue, putative 0.001 0.0116 0.13
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.0889 0.3039
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0463 0.1583
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1348 0.3164
Entamoeba histolytica hypothetical protein 0.0035 0.0564 0.3409
Entamoeba histolytica hypothetical protein 0.0035 0.0564 0.3409
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0211 0.0235
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0129 0.2274 0.2274
Loa Loa (eye worm) cyclin domain-containing protein 0.001 0.0116 0.0117
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Plasmodium falciparum protein kinase 5 0.0053 0.0889 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1016 0.1135
Trypanosoma cruzi hypothetical protein 0.0006 0.004 0.0246
Plasmodium falciparum cyclin 0.0043 0.0706 0.7939
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0085 0.0291
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0505 0.3118
Brugia malayi RasGEF domain containing protein 0.0006 0.004 0.004
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.004 0.004
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0505 0.3118
Toxoplasma gondii cyclin 4, putative 0.001 0.0116 0.1137
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1618 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1016 0.1016
Loa Loa (eye worm) cyclin domain-containing protein 0.001 0.0116 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.0587
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.0889 0.5492
Trypanosoma cruzi hypothetical protein 0.0006 0.004 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1618 0.3818
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.004 0.004
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0772 0.8687
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0085 0.0291
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0889 0.5439
Trichomonas vaginalis cyclin B, putative 0.0043 0.0706 0.161
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0822 0.0832
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0889 0.2053
Entamoeba histolytica hypothetical protein 0.002 0.0283 0.165
Entamoeba histolytica hypothetical protein 0.0011 0.0134 0.0718
Loa Loa (eye worm) hypothetical protein 0.004 0.0645 0.0653
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0062 0.1054 0.1054
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0129 0.2274 0.2274
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0134 0.0825
Trypanosoma cruzi CYC2-like cyclin, putative 0.0073 0.125 0.7722
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0096 0.1665 0.5693
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0772 0.8687
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0134 0.0825
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0845 0.0857
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0134 0.0825
Loa Loa (eye worm) cyclin C 0.001 0.0116 0.0117
Brugia malayi hypothetical protein 0.0009 0.0085 0.0086
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0443 0.0495
Echinococcus granulosus Cyclin L1 0.001 0.0116 0.0129
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1016 0.3476
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.001 0.0116 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0116 0.0183
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.004 0.0136
Brugia malayi N-terminal motif family protein 0.0006 0.004 0.004
Onchocerca volvulus Cyclin L homolog 0.001 0.0116 0.0219
Echinococcus multilocularis ecdysone induced protein 78C 0.0096 0.1665 0.5693
Brugia malayi MH1 domain containing protein 0.0004 0.0007 0.0007
Echinococcus granulosus cyclin B 0.0073 0.125 0.1396
Brugia malayi Cyclin, N-terminal domain containing protein 0.001 0.0116 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.0587
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0005 0.0022 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1348 0.3164
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.1618 0.5534
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0078 0.1348 0.3164
Brugia malayi MH2 domain containing protein 0.0008 0.0072 0.0073
Brugia malayi nuclear hormone receptor family member odr-7 0.0045 0.0747 0.0757
Echinococcus multilocularis G1:S specific cyclin D1 0.001 0.0116 0.0395
Brugia malayi Steroid receptor seven-up type 2 0.0096 0.1665 0.1687
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0096 0.1665 0.1687
Echinococcus multilocularis Protein son of sevenless 0.0006 0.004 0.0136
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.0889 0.0993
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0564 0.1929
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0022 0.0077
Onchocerca volvulus 0.0009 0.0085 0.0161
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.1598 0.5464
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0085 0.0161
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0085 0.0095
Echinococcus granulosus cGMP dependent protein kinase 1 0.0005 0.0022 0.0025
Mycobacterium ulcerans lipoprotein LpqF 0.0062 0.1054 0.1054
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0045 0.0747 0.0835
Toxoplasma gondii hypothetical protein 0.001 0.0116 0.1137
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Loa Loa (eye worm) hypothetical protein 0.0051 0.0845 0.0857
Brugia malayi hypothetical protein 0.001 0.0116 0.0117
Brugia malayi ecdysteroid receptor 0.0096 0.1665 0.1687
Schistosoma mansoni hypothetical protein 0.001 0.0116 0.0395
Echinococcus multilocularis cyclins 0.0043 0.0706 0.2413
Schistosoma mansoni cyclin d 0.001 0.0116 0.0395
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.004 0.0136
Loa Loa (eye worm) hypothetical protein 0.0295 0.5272 0.5341
Echinococcus granulosus cyclin B3 1 0.0043 0.0706 0.0788
Brugia malayi RasGEF domain containing protein 0.0006 0.004 0.004
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.004 0.0136
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0085 0.0291
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0889 0.3039
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0889 0.5492
Schistosoma mansoni coup transcription factor 0.0096 0.1665 0.5693
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0045 0.0747 0.0757
Onchocerca volvulus 0.001 0.0109 0.0206
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0463 0.4555
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0134 0.0825
Loa Loa (eye worm) hypothetical protein 0.0016 0.0211 0.0213
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0043 0.0706 0.2413
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0134 0.0825
Echinococcus granulosus cGMP dependent protein kinase 1 0.0005 0.0022 0.0025
Giardia lamblia Kinase, PLK 0.0093 0.1618 1
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0889 0.5492
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0518 0.0525
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0134 0.0227
Entamoeba histolytica cyclin family protein 0.0043 0.0706 0.4294
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.0587
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.3659 0.3707
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0096 0.1665 0.5693
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0085 0.0086
Loa Loa (eye worm) cyclin domain-containing protein 0.001 0.0116 0.0117
Echinococcus multilocularis cyclin t1 0.001 0.0116 0.0395
Trypanosoma brucei mitotic cyclin 6 0.0073 0.125 0.756
Echinococcus granulosus FTZ F1 alpha 0.0096 0.1665 0.186
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0889 0.5492
Loa Loa (eye worm) steroid hormone receptor 0.0548 0.987 1
Schistosoma mansoni nuclear hormone receptor 0.0096 0.1665 0.5693
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0085 0.0095
Loa Loa (eye worm) nuclear hormone receptor 0.0045 0.0747 0.0757
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0045 0.0747 0.2555
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0845 0.2891
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0096 0.1665 0.1687
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0045 0.0747 0.0757
Schistosoma mansoni thyroid hormone receptor 0.0096 0.1665 0.5693
Brugia malayi orphan nuclear receptor NR2E1 0.0045 0.0747 0.0757
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0096 0.1665 0.1687
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0085 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0463 0.1583
Schistosoma mansoni zinc finger protein 0.0045 0.0747 0.2555
Loa Loa (eye worm) hypothetical protein 0.0052 0.0863 0.0875
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0043 0.0706 0.0788
Trypanosoma brucei mitotic cyclin 0.001 0.0116 0.0054
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0134 0.0825
Echinococcus multilocularis cyclin k 0.001 0.0116 0.0395
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0134 0.0825
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.001 0.0116 0.1137
Plasmodium vivax hypothetical protein, conserved 0.001 0.0116 0.13
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.1618 0.164
Echinococcus granulosus cyclins 0.0043 0.0706 0.0788
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0096 0.1665 0.1687
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0747 0.0757
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.001 0.0116 0.1137
Leishmania major protein kinase, putative 0.0005 0.0022 0.0138
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0085 0.0086
Echinococcus multilocularis cyclins 0.0043 0.0706 0.2413
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0747 0.0757
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1016 0.628
Trypanosoma cruzi cyclin, putative 0.0073 0.125 0.7722
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0045 0.0747 0.2555
Trichomonas vaginalis hypothetical protein 0.0033 0.0527 0.1178
Schistosoma mansoni Smad4 0.0008 0.0072 0.0245
Schistosoma mansoni dep domain containing protein 0.0009 0.0085 0.0291
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0889 0.09
Trypanosoma brucei polo-like protein kinase 0.0093 0.1618 1
Trichomonas vaginalis cyclin B3, putative 0.001 0.0116 0.0183
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.001 0.0116 0.0129
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0085 0.0095
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0073 0.125 0.7722
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0889 0.3039
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0211 0.072
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.004 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0775 0.1778
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0085 0.0086
Echinococcus multilocularis geminin 0.0165 0.2924 1
Schistosoma mansoni hypothetical protein 0.0016 0.0211 0.072
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0748 0.0758
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0072 0.008
Trichomonas vaginalis cyclin B, putative 0.0073 0.125 0.2926
Entamoeba histolytica cyclin, domain containing protein 0.001 0.0116 0.0606
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0539 0.0546
Echinococcus multilocularis cyclins 0.0043 0.0706 0.2413
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0051 0.0845 0.0944
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0005 0.0022 0.0077
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0747 0.1417
Trichomonas vaginalis cyclin B, putative 0.001 0.0116 0.0183
Echinococcus granulosus cyclin y 0.001 0.0116 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.0587
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0107 0.1057
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0463 0.0517
Echinococcus granulosus cyclins 0.0043 0.0706 0.0788
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1348 0.3164
Giardia lamblia Cyclin A 0.0043 0.0706 0.3926
Onchocerca volvulus 0.0234 0.4174 0.7918
Loa Loa (eye worm) hypothetical protein 0.0009 0.0085 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.0587
Trichomonas vaginalis cyclin B, putative 0.0073 0.125 0.2926
Schistosoma mansoni dishevelled 0.0009 0.0085 0.0291
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.002 0.0283 0.0587
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0748 0.2558
Schistosoma mansoni smad 0.0008 0.0072 0.0245
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.004 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0096 0.1665 0.1687
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0645 0.2204
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.0889 0.8744
Trypanosoma cruzi hypothetical protein 0.0004 0.0007 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0748 0.0835
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0463 0.1583
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0211 0.072
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.004 0.0132
Trichomonas vaginalis cyclin B, putative 0.0073 0.125 0.2926
Schistosoma mansoni cyclin G2 0.001 0.0116 0.0395
Brugia malayi nuclear receptor NHR-88 0.0045 0.0747 0.0757
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0211 0.0213
Brugia malayi nuclear hormone receptor 0.0096 0.1665 0.1687
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0096 0.1665 0.186
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.125 0.1266
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0748 0.0758
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0096 0.1665 0.1687
Schistosoma mansoni hypothetical protein 0.0016 0.0211 0.072
Trichomonas vaginalis cyclin D, putative 0.001 0.0116 0.0183
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Brugia malayi Cyclin, N-terminal domain containing protein 0.0073 0.125 0.1266
Loa Loa (eye worm) hypothetical protein 0.0045 0.0747 0.0757
Echinococcus multilocularis expressed protein 0.0047 0.0772 0.264
Loa Loa (eye worm) hypothetical protein 0.0004 0.0007 0.0007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0096 0.1665 0.5693
Echinococcus granulosus expressed protein 0.0047 0.0772 0.0862
Trichomonas vaginalis cyclin B, putative 0.0073 0.125 0.2926
Echinococcus multilocularis cyclin 0.001 0.0116 0.0395
Loa Loa (eye worm) AGC/PKG protein kinase 0.0005 0.0022 0.0023
Schistosoma mansoni smad1 5 8 and 0.0008 0.0072 0.0245
Loa Loa (eye worm) hypothetical protein 0.0096 0.1665 0.1687
Echinococcus granulosus GPCR family 2 0.0016 0.0211 0.0235
Brugia malayi cell division control protein 2 homolog 0.0053 0.0889 0.09
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0889 0.3039
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0047 0.0772 0.0782
Entamoeba histolytica cyclin family protein 0.0043 0.0706 0.4294
Trichomonas vaginalis cyclins, putative 0.0073 0.125 0.2926
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0134 0.0825
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0463 0.1583
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.001 0.0107 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0775 0.1778
Echinococcus multilocularis cyclin B3 1 0.0043 0.0706 0.2413
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Brugia malayi ecdysone receptor 0.0045 0.0747 0.0757
Schistosoma mansoni ras GTP exchange factor 0.0006 0.004 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0116 0.0183
Entamoeba histolytica hypothetical protein 0.0035 0.0564 0.3409
Loa Loa (eye worm) hypothetical protein 0.0045 0.0747 0.0757
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.001 0.0116 0.0395
Trypanosoma brucei cyclin 9 0.001 0.0116 0.0054
Toxoplasma gondii TIM10 family protein, putative 0.0047 0.0772 0.7596
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0096 0.1665 0.1687
Echinococcus multilocularis cyclins 0.0043 0.0706 0.2413
Entamoeba histolytica hypothetical protein 0.0011 0.0134 0.0718
Brugia malayi Pre-SET motif family protein 0.0029 0.0463 0.0469
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0505 0.4964
Trypanosoma cruzi hypothetical protein 0.0004 0.0007 0.0043
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0045 0.0747 0.2555
Brugia malayi nuclear receptor RXR 0.0051 0.0845 0.0857
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0747 0.2555
Onchocerca volvulus 0.0045 0.0747 0.1417
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0134 0.0825
Loa Loa (eye worm) hypothetical protein 0.0096 0.1665 0.1687
Giardia lamblia NADPH oxidoreductase, putative 0.0078 0.1348 0.82
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.1598 0.1785
Loa Loa (eye worm) hypothetical protein 0.0051 0.0845 0.0857
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1618 1
Brugia malayi nuclear receptor NHR-88 0.0096 0.1665 0.1687
Trichomonas vaginalis cyclins, putative 0.001 0.0116 0.0183
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.004 0.0045
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0096 0.1665 0.186
Loa Loa (eye worm) hypothetical protein 0.0006 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0463 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1348 0.3164
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0096 0.1665 0.1687
Loa Loa (eye worm) hypothetical protein 0.0096 0.1665 0.1687
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0747 0.0835
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0134 0.0825
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0072 0.0245
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0085 0.0291
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0068 0.1157 0.3958
Schistosoma mansoni nuclear receptor 0.0045 0.0747 0.2555
Schistosoma mansoni hypothetical protein 0.001 0.0116 0.0395
Loa Loa (eye worm) hypothetical protein 0.0073 0.125 0.1266
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.0587
Brugia malayi DIX domain containing protein 0.0009 0.0085 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0005 0.0022 0.0077
Echinococcus multilocularis FTZ F1 alpha 0.0096 0.1665 0.5693
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.1618 1
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.0889 0.5171
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0706 0.161
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0321 0.1984
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1348 0.3164
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0006 0.004 0.0076
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.004 0.0136
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0072 0.0245
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Schistosoma mansoni peptidase 0.0004 0.0006 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1618 0.3818
Schistosoma mansoni smad1 5 8 and 0.0008 0.0072 0.0245
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0505 0.3037
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0072 0.008
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0645 0.0653
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.004 0.0045
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0505 0.3118
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0747 0.2555
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0505 0.2628
Trypanosoma cruzi mitotic cyclin, putative 0.001 0.0116 0.0714
Schistosoma mansoni nuclear receptor 0.0045 0.0747 0.2555
Echinococcus granulosus ras GTP exchange factor 0.0006 0.004 0.0045
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.0889 0.0993
Trichomonas vaginalis cyclin D, putative 0.0043 0.0706 0.161
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0772 0.7596
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0889 0.3039
Leishmania major mitotic cyclin, putative 0.001 0.0116 0.0714
Echinococcus granulosus cyclins 0.0043 0.0706 0.0788
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1016 0.1016
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.1598 0.1785
Onchocerca volvulus 0.0029 0.0463 0.0878
Brugia malayi conserved hypotetical protein 0.0045 0.0747 0.0757
Plasmodium falciparum cyclin 1 0.001 0.0116 0.13
Trichomonas vaginalis cyclin D, putative 0.0043 0.0706 0.161
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0116 0.0714
Trichomonas vaginalis modulator of drug activity B, putative 0.002 0.0283 0.0587
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0096 0.1665 0.1687
Leishmania major cyclin 0.0073 0.125 0.7722
Trichomonas vaginalis cyclin A, putative 0.0073 0.125 0.2926
Echinococcus multilocularis expressed conserved protein 0.0005 0.0022 0.0077
Entamoeba histolytica hypothetical protein 0.0011 0.0134 0.0718

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.94 uM Inhibition of CDK4/Cyclin D1 assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation ChEMBL. 19317452
IC50 (binding) = 3.1 uM Inhibition of CDK2/Cyclin E assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation ChEMBL. 19317452
IC50 (binding) = 8.1 uM Inhibition of CDK1/Cyclin B1 assessed as inhibition of retinoblastoma susceptibility gene product phosphorylation ChEMBL. 19317452

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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