Detailed information for compound 994998

Basic information

Technical information
  • TDR Targets ID: 994998
  • Name: 5-chloro-N-[5-(1,2-dihydroxyethyl)pyridin-2-y l]-1H-indole-2-carboxamide
  • MW: 331.754 | Formula: C16H14ClN3O3
  • H donors: 4 H acceptors: 4 LogP: 1.57 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(c1ccc(nc1)NC(=O)c1cc2c([nH]1)ccc(c2)Cl)O
  • InChi: 1S/C16H14ClN3O3/c17-11-2-3-12-10(5-11)6-13(19-12)16(23)20-15-4-1-9(7-18-15)14(22)8-21/h1-7,14,19,21-22H,8H2,(H,18,20,23)
  • InChiKey: BTLBOZYNWCWYHS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-N-[5-(1,2-dihydroxyethyl)-2-pyridyl]-1H-indole-2-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphorylase, glycogen, liver Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis glycogen phosphorylase 1 Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
Chlamydia trachomatis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis Glycosyl transferase, family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium parvum glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Onchocerca volvulus Glycogen phosphorylase homolog Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Neospora caninum hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Giardia lamblia Glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum Glycogen phosphorylase, brain form, putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus Glycosyl transferase family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Brugia malayi carbohydrate phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Loa Loa (eye worm) glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0078 0.0119
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.03 0.1617
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.1144 0.6168
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0068 0.0096
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1144 0.1612
Schistosoma mansoni hypothetical protein 0.0015 0.0196 0.0276
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0036 0.0051
Loa Loa (eye worm) hypothetical protein 0.0073 0.1451 0.2101
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.03 0.1617
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.001 0.0014
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.03 0.0458
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0113
Mycobacterium tuberculosis Conserved protein 0.0073 0.1451 0.1187
Loa Loa (eye worm) hypothetical protein 0.0006 0.0000050421 0.0000072975
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1854 0.3508
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.03 0.1617
Trypanosoma brucei unspecified product 0.0014 0.0165 0.0889
Brugia malayi nuclear hormone receptor 0.001 0.0078 0.0119
Onchocerca volvulus 0.0019 0.028 0.0428
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0078 0.011
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0548 0.0772
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.3007 0.4237
Brugia malayi hypothetical protein 0.0019 0.028 0.0428
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0078 0.0119
Echinococcus granulosus dna polymerase eta 0.002 0.03 0.0422
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.001 0.0037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1451 0.2045
Trichomonas vaginalis ran, putative 0.0022 0.0351 0.0663
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1854 0.3508
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0525 0.3617
Loa Loa (eye worm) hypothetical protein 0.0019 0.028 0.0406
Loa Loa (eye worm) glycogen phosphorylase 0.013 0.2682 0.3882
Echinococcus granulosus glycogen phosphorylase 0.013 0.2682 0.378
Echinococcus granulosus glycogen phosphorylase 0.013 0.2682 0.378
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.1451 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1451 0.2746
Mycobacterium ulcerans hypothetical protein 0.0073 0.1451 1
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1451 0.2746
Schistosoma mansoni rab6-interacting 0.0019 0.028 0.0395
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1854 0.3508
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0351 0.2417
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.091 0.139
Schistosoma mansoni hypothetical protein 0.0033 0.0579 0.0816
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.1451 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0000050421 0.0000071047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0078 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0078 0.0113
Schistosoma mansoni rab6-interacting 0.0019 0.028 0.0395
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.001 0.0037
Leishmania major DNA polymerase eta, putative 0.002 0.03 0.1617
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.03 0.1617
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0196 0.0276
Loa Loa (eye worm) MBCTL1 0.0057 0.1088 0.1575
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1144 0.788
Loa Loa (eye worm) Smad1 0.0008 0.0036 0.0051
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0003 0.0004
Leishmania major DNA polymerase kappa, putative 0.002 0.03 0.1617
Plasmodium vivax importin-beta 2, putative 0.0031 0.0525 0.3617
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.1451 0.2045
Onchocerca volvulus Glycogen phosphorylase homolog 0.013 0.2682 0.4099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0078 0.0119
Loa Loa (eye worm) hypothetical protein 0.0009 0.0068 0.0099
Echinococcus multilocularis RUN 0.0019 0.028 0.0395
Entamoeba histolytica Ran family GTPase 0.0022 0.0351 0.1307
Brugia malayi RasGEF domain containing protein 0.0007 0.001 0.0015
Giardia lamblia Kinase, PLK 0.0092 0.1854 0.6913
Onchocerca volvulus 0.0073 0.1451 0.2218
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.001 0.0037
Echinococcus multilocularis glycogen phosphorylase 0.013 0.2682 0.378
Trichomonas vaginalis set domain proteins, putative 0.0251 0.5286 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1854 0.3508
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0000050421 0.0000071047
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0000050421 0.0000071047
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0196 0.0276
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0068 0.0096
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0078 0.011
Echinococcus multilocularis geminin 0.0335 0.7097 1
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0000050421 0.0000077049
Mycobacterium leprae Probable lipase LipE 0.0073 0.1451 0.5
Brugia malayi beta-lactamase family protein 0.0073 0.1451 0.2218
Schistosoma mansoni hypothetical protein 0.0335 0.7097 1
Loa Loa (eye worm) hypothetical protein 0.002 0.03 0.0434
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0548 0.0772
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0036 0.005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0548 0.0772
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.001 0.0015
Giardia lamblia DINP protein human, muc B family 0.002 0.03 0.1118
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.085 0.1608
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0939 0.1435
Toxoplasma gondii hypothetical protein 0.0009 0.0068 0.0471
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0000050421 0.0000071047
Schistosoma mansoni lipoxygenase 0.0019 0.028 0.0395
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.03 0.0434
Brugia malayi MH1 domain containing protein 0.0008 0.0036 0.0054
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0196 0.0276
Schistosoma mansoni dishevelled 0.0009 0.0068 0.0096
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0000050421 0.0000071047
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.1028 0.1448
Loa Loa (eye worm) hypothetical protein 0.0057 0.1088 0.1575
Loa Loa (eye worm) hypothetical protein 0.0019 0.028 0.0406
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0006 0.0000050421 0.0000072975
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.001 0.0037
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0056 0.1083 0.0808
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0078 0.0119
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0191 0.3996 0.6107
Leishmania major importin beta-1 subunit, putative 0.0025 0.04 0.2158
Schistosoma mansoni lipoxygenase 0.0054 0.1028 0.1448
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0939 0.1324
Schistosoma mansoni ras GTP exchange factor 0.0007 0.001 0.0014
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0006 0.0000050421 0.0000077049
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1144 0.788
Echinococcus multilocularis smad 0.0008 0.0036 0.005
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0078 0.011
Schistosoma mansoni ran 0.0022 0.0351 0.0494
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0000050421 0.0000071047
Brugia malayi ecdysteroid receptor 0.001 0.0078 0.0119
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.3007 0.4595
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.03 0.1617
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0068 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1854 0.2613
Onchocerca volvulus 0.0007 0.001 0.0015
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1451 0.2746
Schistosoma mansoni hypothetical protein 0.0015 0.0196 0.0276
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.001 0.0037
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0351 0.1892
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.1451 0.2218
Brugia malayi N-terminal motif family protein 0.0191 0.3996 0.6107
Schistosoma mansoni hypothetical protein 0.0302 0.6396 0.9013
Trichomonas vaginalis esterase, putative 0.0073 0.1451 0.2746
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0579 0.0885
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2367 0.3426
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.028 0.0395
Loa Loa (eye worm) hypothetical protein 0.0032 0.0548 0.0793
Loa Loa (eye worm) hypothetical protein 0.0015 0.0196 0.0283
Loa Loa (eye worm) hypothetical protein 0.0073 0.1451 0.2101
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.0015
Schistosoma mansoni ran 0.0022 0.0351 0.0494
Schistosoma mansoni nuclear hormone receptor 0.001 0.0078 0.011
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0000050421 0.0000077049
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.028 0.0395
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.1088 0.1533
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0068 0.0096
Echinococcus granulosus son of sevenless 1 0.0007 0.001 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1451 0.7828
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.03 0.0422
Trypanosoma brucei unspecified product 0.0014 0.0165 0.0889
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1451 0.7828
Loa Loa (eye worm) hypothetical protein 0.0009 0.0068 0.0099
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0113
Plasmodium vivax SET domain protein, putative 0.0032 0.0548 0.3777
Mycobacterium ulcerans DNA polymerase IV 0.002 0.03 0.2065
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.03 0.1617
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1854 0.2833
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0351 0.1892
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0006 0.0000050421 0.0000077049
Trypanosoma brucei polo-like protein kinase 0.0092 0.1854 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1144 0.788
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0068 0.0096
Loa Loa (eye worm) hypothetical protein 0.005 0.0939 0.136
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.4628 0.6698
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0939 0.1324
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.03 0.0567
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0196 0.0283
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.1451 0.1187
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0000050421 0.0000071047
Brugia malayi hypothetical protein 0.0006 0.0000050421 0.0000077049
Brugia malayi beta-lactamase family protein 0.0073 0.1451 0.2218
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0000050421 0.0000077049
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0351 0.1892
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2367 0.3426
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.001 0.0014
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1854 0.2613
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.1451 0.1187
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0113
Brugia malayi Pre-SET motif family protein 0.0032 0.0548 0.0838
Loa Loa (eye worm) doublecortin family protein 0.0019 0.028 0.0406
Schistosoma mansoni DNA polymerase eta 0.002 0.03 0.0422
Plasmodium vivax hypothetical protein, conserved 0.0073 0.1451 1
Schistosoma mansoni loxhd1 0.0019 0.028 0.0395
Echinococcus granulosus smad 0.0008 0.0036 0.005
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.001 0.0014
Brugia malayi hypothetical protein 0.0309 0.6544 1
Trichomonas vaginalis glycogen phosphorylase, putative 0.013 0.2682 0.5074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0196 0.0299
Echinococcus multilocularis Glycosyl transferase, family 35 0.013 0.2682 0.378
Echinococcus granulosus snurportin 1 0.0326 0.6909 0.9736
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0548 0.0772
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.03 0.1617
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0939 0.1324
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.1088 0.1533
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1854 0.6913
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.3007 0.4237
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1854 0.2833
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0068 0.0105
Entamoeba histolytica glycogen phosphorylase, putative 0.0056 0.1083 0.4038
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.03 0.0458
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0078 0.011
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.1451 0.1187
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0165 0.0889
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.03 0.1617
Onchocerca volvulus 0.0032 0.0548 0.0838
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.03 0.1617
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0078 0.011
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0525 0.2831
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0068 0.0096
Echinococcus multilocularis dna polymerase kappa 0.002 0.03 0.0422
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0006 0.0000050421 0.0000077049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0548 0.0772
Loa Loa (eye worm) hypothetical protein 0.0309 0.6544 0.9471
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1854 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.03 0.1617
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0078 0.011
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0078 0.0119
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0078 0.0119
Loa Loa (eye worm) hypothetical protein 0.0048 0.091 0.1317
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0196 0.0276
Mycobacterium ulcerans beta-lactamase 0.0073 0.1451 1
Brugia malayi Smad1 0.0008 0.0036 0.0054
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0326 0.6909 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.1088 0.1663
Schistosoma mansoni thyroid hormone receptor 0.001 0.0078 0.011
Brugia malayi MH2 domain containing protein 0.0116 0.2367 0.3617
Brugia malayi DIX domain containing protein 0.0009 0.0068 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.085 0.1608
Echinococcus granulosus Protein son of sevenless 0.0007 0.001 0.0014
Toxoplasma gondii ABC1 family protein 0.0073 0.1451 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.03 0.0422
Loa Loa (eye worm) hypothetical protein 0.0009 0.0068 0.0099
Loa Loa (eye worm) hypothetical protein 0.0073 0.1451 0.2101
Echinococcus granulosus importin subunit beta 1 0.0031 0.0525 0.074
Schistosoma mansoni Smad4 0.0008 0.0036 0.005
Echinococcus multilocularis dna polymerase eta 0.002 0.03 0.0422
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0351 0.2417
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.4099 0.5775
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0078 0.011
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1854 0.3508
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0000050421 0.0000071047
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0078 0.0119
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0056 0.1083 0.7463
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.03 0.1617
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.03 0.1617
Brugia malayi RasGEF domain containing protein 0.0007 0.001 0.0015
Brugia malayi steroid hormone receptor 0.001 0.0078 0.0119
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0007 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0073 0.1451 0.2101
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.1451 0.7828
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0068 0.0096
Brugia malayi N-terminal motif family protein 0.0007 0.001 0.0015
Schistosoma mansoni hypothetical protein 0.0015 0.0196 0.0276
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0078 0.011
Schistosoma mansoni hypothetical protein 0.0326 0.6909 0.9736
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1854 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0113
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.001 0.0037
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0078 0.011
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0113
Mycobacterium tuberculosis Conserved protein 0.0073 0.1451 0.1187
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0351 0.6681
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0036 0.005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.3007 0.4237
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0939 0.1324
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0068 0.0105
Mycobacterium ulcerans DNA polymerase IV 0.002 0.03 0.2065
Echinococcus granulosus Smad4 0.0008 0.0036 0.005
Schistosoma mansoni hypothetical protein 0.0015 0.0196 0.0276
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0078 0.0119
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0068 0.0096
Trypanosoma brucei unspecified product 0.002 0.03 0.1617
Echinococcus multilocularis glycogen phosphorylase 0.013 0.2682 0.378
Schistosoma mansoni thyroid hormone receptor 0.001 0.0078 0.011
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.1144 0.1612
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.3007 0.4237
Brugia malayi G-protein alpha subunit 0.0006 0.0000050421 0.0000077049
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0006 0.0000050421 0.0000072975
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0351 0.0494
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0078 0.011
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.0015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0078 0.011
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0068 0.0096
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0078 0.011
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0078 0.0119
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.001 0.0037
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0000050421 0.0000071047
Trypanosoma cruzi hypothetical protein 0.0007 0.001 0.0054
Loa Loa (eye worm) hypothetical protein 0.0006 0.0000050421 0.0000072975
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.1451 0.1187
Onchocerca volvulus 0.001 0.0078 0.0119
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0939 0.1324
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.1088 0.1533
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.001 0.0014
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0351 0.1308
Entamoeba histolytica hypothetical protein 0.0025 0.04 0.1492
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.001 0.0019
Brugia malayi Importin beta-1 subunit 0.0031 0.0525 0.0802
Loa Loa (eye worm) hypothetical protein 0.0006 0.0000050421 0.0000072975
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0078 0.0119
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.091 0.1317
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0006 0.0000050421 0.0000077049
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0078 0.011
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0068 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.03 0.1617
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1854 0.3508
Trichomonas vaginalis importin beta-1, putative 0.0025 0.04 0.0757
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.4099 0.5775
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.03 0.1617
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0078 0.0113
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.1144 0.788
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0078 0.0119
Schistosoma mansoni smad1 5 8 and 0.0008 0.0036 0.005
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.001 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1854 0.3508
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.03 0.1117
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0548 0.3777
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0165 0.0889
Brugia malayi RNA, U transporter 1 0.0087 0.1742 0.2661
Trichomonas vaginalis glycogen phosphorylase, putative 0.013 0.2682 0.5074
Brugia malayi RasGEF domain containing protein 0.0007 0.001 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1451 0.2746
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0007 0.001 0.0015
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.028 0.1931
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0078 0.011
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0007 0.001 0.0019
Leishmania major GTP-binding protein, putative 0.0022 0.0351 0.1892
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.3007 0.4237
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.1028 0.1448
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0523 0.0737
Schistosoma mansoni hypothetical protein 0.0019 0.028 0.0395
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.03 0.1617
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.03 0.1617
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.1144 0.1612
Brugia malayi Pre-SET motif family protein 0.022 0.4628 0.7072
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.001 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0078 0.0119
Loa Loa (eye worm) hypothetical protein 0.0191 0.3996 0.5784
Brugia malayi beta-lactamase 0.0073 0.1451 0.2218
Schistosoma mansoni dishevelled 0.0009 0.0068 0.0096
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.1451 0.2101
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0525 0.2831
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0078 0.0119
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.028 0.0395
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.3007 0.4237
Schistosoma mansoni glycogen phosphorylase 0.013 0.2682 0.378
Mycobacterium ulcerans lipase LipD 0.0073 0.1451 1
Brugia malayi carbohydrate phosphorylase 0.013 0.2682 0.4099
Echinococcus multilocularis snurportin 1 0.0326 0.6909 0.9736
Schistosoma mansoni smad1 5 8 and 0.0008 0.0036 0.005
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0113
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.03 0.1617
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.1088 0.1533
Schistosoma mansoni hypothetical protein 0.0335 0.7097 1
Brugia malayi MH2 domain containing protein 0.0008 0.0036 0.0054
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.001 0.0037
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0078 0.011
Loa Loa (eye worm) hypothetical protein 0.0006 0.0000050421 0.0000072975
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1144 0.1612
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0078 0.0113
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0939 0.136
Loa Loa (eye worm) hypothetical protein 0.0073 0.1451 0.2101
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0000050421 0.0000071047
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0525 0.074
Entamoeba histolytica hypothetical protein 0.0007 0.001 0.0037
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1854 0.2684
Plasmodium falciparum importin beta, putative 0.0031 0.0525 1
Loa Loa (eye worm) G protein alpha subunit 3 0.0006 0.0000050421 0.0000072975
Entamoeba histolytica glycogen phosphorylase, putative 0.013 0.2682 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0006 0.0000050421 0.0000072975
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0078 0.011
Echinococcus granulosus RUN 0.0019 0.028 0.0395
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1451 0.2045
Schistosoma mansoni kinase 0.0047 0.0876 0.1234
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.001 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0078 0.0113
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0078 0.011
Schistosoma mansoni glycogen phosphorylase 0.013 0.2682 0.378
Brugia malayi Doublecortin family protein 0.0019 0.028 0.0428
Loa Loa (eye worm) hypothetical protein 0.0033 0.0579 0.0838
Trypanosoma cruzi hypothetical protein 0.0007 0.001 0.0054
Brugia malayi mbt repeat family protein 0.005 0.0939 0.1436
Echinococcus granulosus dna polymerase kappa 0.002 0.03 0.0422
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.001 0.0037
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0006 0.0000050421 0.0000077049
Loa Loa (eye worm) beta-lactamase 0.0073 0.1451 0.2101
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.001 0.0014
Echinococcus multilocularis GPCR, family 2 0.0015 0.0196 0.0276
Onchocerca volvulus 0.0073 0.1451 0.2218
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0006 0.0000050421 0.0000071047
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.028 0.0395
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.04 0.0757
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0000050421 0.0000071047
Schistosoma mansoni importin beta-1 0.0031 0.0525 0.074
Echinococcus multilocularis Protein son of sevenless 0.0007 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0525 0.076
Brugia malayi hypothetical protein 0.0009 0.0068 0.0105
Schistosoma mansoni smad 0.0008 0.0036 0.005
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0006 0.0000050421 0.0000072975
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.1451 0.1187
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.091 0.139
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0078 0.0113
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0939 0.1324
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0548 0.0772
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0196 0.0299
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.001 0.0037
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.03 0.0422
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.1088 0.1533
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.1451 0.2045
Onchocerca volvulus 0.0073 0.1451 0.2218
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0078 0.0119
Onchocerca volvulus 0.0251 0.5286 0.8077
Schistosoma mansoni glycogen phosphorylase 0.0056 0.1083 0.1526
Brugia malayi N-terminal motif family protein 0.0007 0.001 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0078 0.0113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0548 0.0772
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0068 0.0105
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.001 0.0014
Echinococcus multilocularis son of sevenless 1 0.0007 0.001 0.0014
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0006 0.0000050421 0.0000071047
Brugia malayi MH2 domain containing protein 0.0008 0.0036 0.0054
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.001 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.03 0.1617
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0078 0.011
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.028 0.0395
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0939 0.1324
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0068 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0165 0.0889
Schistosoma mansoni dep domain containing protein 0.0009 0.0068 0.0096
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.3007 0.4352
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0078 0.0113
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0078 0.011
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0078 0.0119
Leishmania major hypothetical protein, conserved 0.0073 0.1451 0.7828
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1854 0.2613
Entamoeba histolytica glycogen phosphorylase, putative 0.013 0.2682 1
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.028 0.5339
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.1144 0.087
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.03 0.1617
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.3007 0.4237
Echinococcus granulosus FTZ F1 alpha 0.001 0.0078 0.011
Onchocerca volvulus 0.0309 0.6544 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1451 0.2101
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.001 0.0019
Brugia malayi MH1 domain containing protein 0.0008 0.0036 0.0054
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1854 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0351 0.0536
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0036 0.005
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0078 0.011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0078 0.011
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0078 0.0119
Schistosoma mansoni smad1 5 8 and 0.0008 0.0036 0.005
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1451 0.2746
Onchocerca volvulus 0.005 0.0939 0.1435
Brugia malayi hypothetical protein 0.0009 0.0068 0.0105
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0068 0.0096
Entamoeba histolytica glycogen phosphorylase, putative 0.0056 0.1083 0.4038
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0068 0.0096
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0068 0.0096
Giardia lamblia Glycogen phosphorylase 0.013 0.2682 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.001 0.0037
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.03 0.0422
Loa Loa (eye worm) hypothetical protein 0.0006 0.0000050421 0.0000072975
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0078 0.011
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.1451 0.1187
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0078 0.011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0078 0.011
Brugia malayi mbt repeat family protein 0.005 0.0939 0.1436
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0068 0.0099
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0007 0.001 0.0054
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0078 0.0119
Echinococcus multilocularis Smad4 0.0008 0.0036 0.005
Brugia malayi nuclear receptor NHR-88 0.001 0.0078 0.0119
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0078 0.011
Echinococcus granulosus geminin 0.0335 0.7097 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.04 0.0757
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.001 0.0015
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.028 0.0395
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.001 0.0014
Echinococcus granulosus GPCR family 2 0.0015 0.0196 0.0276
Onchocerca volvulus 0.0009 0.0068 0.0104
Schistosoma mansoni polycystin 1-related 0.0019 0.028 0.0395
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0078 0.011
Chlamydia trachomatis glycogen phosphorylase 0.013 0.2682 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.03 0.1617
Entamoeba histolytica glycogenphosphorylase, putative 0.0056 0.1083 0.4038
Echinococcus granulosus Glycosyl transferase family 35 0.013 0.2682 0.378
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0113
Mycobacterium tuberculosis Conserved protein 0.0073 0.1451 0.1187
Schistosoma mansoni coup transcription factor 0.001 0.0078 0.011
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0068 0.0104
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0351 0.0494
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0036 0.0051
Mycobacterium leprae conserved hypothetical protein 0.0073 0.1451 0.5
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0036 0.005
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.1451 0.1187
Echinococcus granulosus ras GTP exchange factor 0.0007 0.001 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0078 0.0119
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.03 0.0567
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0006 0.0000050421 0.0000077049
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0351 0.0508
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0036 0.005
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0078 0.0113
Brugia malayi hypothetical protein 0.0019 0.028 0.0428
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.04 0.2158
Onchocerca volvulus 0.0019 0.028 0.0428

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 13 % Hypoglycemic activity against C57BL/KsJ db/db mouse assessed as reduction of blood glucose at 30 mg/kg, po after 2 hrs relative to control ChEMBL. 18434170
Activity (functional) = 26 % Hypoglycemic activity against C57BL/KsJ db/db mouse assessed as reduction of blood glucose at 50 mg/kg, po after 2 hrs relative to control ChEMBL. 18434170
IC50 (binding) = 0.25 uM Inhibition of human liver glycogen phosphorylase a ChEMBL. 18434170

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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